-- dump date 20140619_075310 -- class Genbank::misc_feature -- table misc_feature_note -- id note 634500000001 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 634500000002 active site 634500000003 catalytic residues [active] 634500000004 DNA binding site [nucleotide binding] 634500000005 Int/Topo IB signature motif; other site 634500000006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 634500000007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500000008 P-loop; other site 634500000009 Magnesium ion binding site [ion binding]; other site 634500000010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500000011 Magnesium ion binding site [ion binding]; other site 634500000012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 634500000013 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 634500000014 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 634500000015 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 634500000016 Ligand binding site; other site 634500000017 metal-binding site 634500000018 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 634500000019 O-Antigen ligase; Region: Wzy_C; pfam04932 634500000020 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 634500000021 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 634500000022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 634500000023 Transposase; Region: DEDD_Tnp_IS110; pfam01548 634500000024 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 634500000025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500000026 dimerization interface [polypeptide binding]; other site 634500000027 putative DNA binding site [nucleotide binding]; other site 634500000028 putative Zn2+ binding site [ion binding]; other site 634500000029 arsenical pump membrane protein; Provisional; Region: PRK15445 634500000030 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 634500000031 transmembrane helices; other site 634500000032 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 634500000033 ArsC family; Region: ArsC; pfam03960 634500000034 catalytic residues [active] 634500000035 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 634500000036 Cupin; Region: Cupin_6; pfam12852 634500000037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500000038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500000039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500000040 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500000041 active site 634500000042 catalytic tetrad [active] 634500000043 Nitrate and nitrite sensing; Region: NIT; pfam08376 634500000044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500000045 dimerization interface [polypeptide binding]; other site 634500000046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000047 dimer interface [polypeptide binding]; other site 634500000048 putative CheW interface [polypeptide binding]; other site 634500000049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500000050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500000051 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 634500000052 classical (c) SDRs; Region: SDR_c; cd05233 634500000053 NAD(P) binding site [chemical binding]; other site 634500000054 active site 634500000055 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 634500000056 classical (c) SDRs; Region: SDR_c; cd05233 634500000057 NAD(P) binding site [chemical binding]; other site 634500000058 active site 634500000059 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500000060 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500000061 FMN binding site [chemical binding]; other site 634500000062 active site 634500000063 substrate binding site [chemical binding]; other site 634500000064 catalytic residue [active] 634500000065 Pirin-related protein [General function prediction only]; Region: COG1741 634500000066 Pirin; Region: Pirin; pfam02678 634500000067 Isochorismatase family; Region: Isochorismatase; pfam00857 634500000068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 634500000069 catalytic triad [active] 634500000070 conserved cis-peptide bond; other site 634500000071 transcriptional regulator; Provisional; Region: PRK10632 634500000072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500000073 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500000074 putative effector binding pocket; other site 634500000075 dimerization interface [polypeptide binding]; other site 634500000076 Pirin-related protein [General function prediction only]; Region: COG1741 634500000077 Pirin; Region: Pirin; pfam02678 634500000078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500000079 putative DNA binding site [nucleotide binding]; other site 634500000080 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 634500000081 putative Zn2+ binding site [ion binding]; other site 634500000082 AsnC family; Region: AsnC_trans_reg; pfam01037 634500000083 ornithine cyclodeaminase; Validated; Region: PRK07589 634500000084 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 634500000085 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 634500000086 Amidinotransferase; Region: Amidinotransf; pfam02274 634500000087 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 634500000088 multiple promoter invertase; Provisional; Region: mpi; PRK13413 634500000089 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 634500000090 catalytic residues [active] 634500000091 catalytic nucleophile [active] 634500000092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 634500000093 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 634500000094 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 634500000095 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 634500000096 integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757 634500000097 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 634500000098 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 634500000099 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634500000100 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 634500000101 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 634500000102 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 634500000103 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 634500000104 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 634500000105 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 634500000106 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 634500000107 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 634500000108 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 634500000109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500000110 AAA domain; Region: AAA_23; pfam13476 634500000111 Walker A/P-loop; other site 634500000112 ATP binding site [chemical binding]; other site 634500000113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500000114 Q-loop/lid; other site 634500000115 ABC transporter signature motif; other site 634500000116 Walker B; other site 634500000117 D-loop; other site 634500000118 H-loop/switch region; other site 634500000119 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 634500000120 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 634500000121 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 634500000122 Restriction endonuclease; Region: Mrr_cat; pfam04471 634500000123 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 634500000124 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500000125 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500000126 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 634500000127 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 634500000128 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 634500000129 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 634500000130 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 634500000131 dimer interface [polypeptide binding]; other site 634500000132 ssDNA binding site [nucleotide binding]; other site 634500000133 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634500000134 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 634500000135 DNA topoisomerase III; Provisional; Region: PRK07726 634500000136 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 634500000137 active site 634500000138 putative interdomain interaction site [polypeptide binding]; other site 634500000139 putative metal-binding site [ion binding]; other site 634500000140 putative nucleotide binding site [chemical binding]; other site 634500000141 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 634500000142 domain I; other site 634500000143 DNA binding groove [nucleotide binding] 634500000144 phosphate binding site [ion binding]; other site 634500000145 domain II; other site 634500000146 domain III; other site 634500000147 nucleotide binding site [chemical binding]; other site 634500000148 catalytic site [active] 634500000149 domain IV; other site 634500000150 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500000151 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 634500000152 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 634500000153 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 634500000154 ParB-like nuclease domain; Region: ParBc; cl02129 634500000155 replicative DNA helicase; Region: DnaB; TIGR00665 634500000156 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 634500000157 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 634500000158 Walker A motif; other site 634500000159 ATP binding site [chemical binding]; other site 634500000160 Walker B motif; other site 634500000161 DNA binding loops [nucleotide binding] 634500000162 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 634500000163 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634500000164 active site 634500000165 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 634500000166 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 634500000167 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 634500000168 Family description; Region: UvrD_C_2; pfam13538 634500000169 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 634500000170 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 634500000171 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 634500000172 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 634500000173 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 634500000174 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 634500000175 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 634500000176 Integrase; Region: Integrase_1; pfam12835 634500000177 Initiator Replication protein; Region: Rep_3; pfam01051 634500000178 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 634500000179 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500000180 Catalytic site [active] 634500000181 silverDB:pEb10200175 634500000182 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634500000183 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 634500000184 active site 634500000185 DNA binding site [nucleotide binding] 634500000186 Int/Topo IB signature motif; other site 634500000187 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 634500000188 active site 634500000189 catalytic residues [active] 634500000190 DNA binding site [nucleotide binding] 634500000191 Int/Topo IB signature motif; other site 634500000192 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 634500000193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500000194 chromosome condensation membrane protein; Provisional; Region: PRK14196 634500000195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500000196 catalytic core [active] 634500000197 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500000198 enolase; Provisional; Region: eno; PRK00077 634500000199 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 634500000200 dimer interface [polypeptide binding]; other site 634500000201 metal binding site [ion binding]; metal-binding site 634500000202 substrate binding pocket [chemical binding]; other site 634500000203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634500000204 Ligand Binding Site [chemical binding]; other site 634500000205 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 634500000206 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 634500000207 DHHA2 domain; Region: DHHA2; pfam02833 634500000208 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 634500000209 putative uracil binding site [chemical binding]; other site 634500000210 putative active site [active] 634500000211 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 634500000212 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 634500000213 gating phenylalanine in ion channel; other site 634500000214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 634500000215 structural tetrad; other site 634500000216 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 634500000217 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 634500000218 DNA binding site [nucleotide binding] 634500000219 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 634500000220 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 634500000221 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 634500000222 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 634500000223 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634500000224 active site 634500000225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500000226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 634500000227 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 634500000228 DNA-binding interface [nucleotide binding]; DNA binding site 634500000229 HTH-like domain; Region: HTH_21; pfam13276 634500000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 634500000231 Integrase core domain; Region: rve; pfam00665 634500000232 Integrase core domain; Region: rve_3; pfam13683 634500000233 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 634500000234 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 634500000235 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 634500000236 FOG: CBS domain [General function prediction only]; Region: COG0517 634500000237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 634500000238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500000239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500000240 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 634500000241 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 634500000242 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 634500000243 ferrochelatase; Reviewed; Region: hemH; PRK00035 634500000244 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 634500000245 C-terminal domain interface [polypeptide binding]; other site 634500000246 active site 634500000247 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 634500000248 active site 634500000249 N-terminal domain interface [polypeptide binding]; other site 634500000250 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 634500000251 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 634500000252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500000253 motif II; other site 634500000254 Predicted membrane protein [Function unknown]; Region: COG4325 634500000255 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 634500000256 Predicted membrane protein [Function unknown]; Region: COG4325 634500000257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000258 active site 634500000259 metal binding site [ion binding]; metal-binding site 634500000260 I-site; other site 634500000261 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000263 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 634500000264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 634500000265 non-specific DNA binding site [nucleotide binding]; other site 634500000266 salt bridge; other site 634500000267 potential frameshift: common BLAST hit: gi|291618992|ref|YP_003521734.1| YddU 634500000268 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500000269 GAF domain; Region: GAF; pfam01590 634500000270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000271 Cache domain; Region: Cache_1; pfam02743 634500000272 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000273 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000274 metal binding site [ion binding]; metal-binding site 634500000275 active site 634500000276 I-site; other site 634500000277 GAF domain; Region: GAF; pfam01590 634500000278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500000279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000281 metal binding site [ion binding]; metal-binding site 634500000282 active site 634500000283 I-site; other site 634500000284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000285 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500000286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000287 dimer interface [polypeptide binding]; other site 634500000288 putative CheW interface [polypeptide binding]; other site 634500000289 potential frameshift: common BLAST hit: gi|291618981|ref|YP_003521723.1| Tar 634500000290 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 634500000291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000292 dimer interface [polypeptide binding]; other site 634500000293 putative CheW interface [polypeptide binding]; other site 634500000294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 634500000295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000297 metal binding site [ion binding]; metal-binding site 634500000298 active site 634500000299 I-site; other site 634500000300 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500000301 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500000302 Predicted membrane protein [Function unknown]; Region: COG2323 634500000303 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 634500000304 DinB family; Region: DinB; cl17821 634500000305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500000306 PAS domain; Region: PAS_9; pfam13426 634500000307 putative active site [active] 634500000308 heme pocket [chemical binding]; other site 634500000309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500000310 PAS domain; Region: PAS_9; pfam13426 634500000311 putative active site [active] 634500000312 heme pocket [chemical binding]; other site 634500000313 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000314 dimer interface [polypeptide binding]; other site 634500000315 putative CheW interface [polypeptide binding]; other site 634500000316 Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; Region: CDC39; COG5103 634500000317 Cache domain; Region: Cache_1; pfam02743 634500000318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000319 metal binding site [ion binding]; metal-binding site 634500000320 active site 634500000321 I-site; other site 634500000322 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634500000323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500000324 dimerization interface [polypeptide binding]; other site 634500000325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000326 dimer interface [polypeptide binding]; other site 634500000327 putative CheW interface [polypeptide binding]; other site 634500000328 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 634500000329 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500000330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000331 dimer interface [polypeptide binding]; other site 634500000332 putative CheW interface [polypeptide binding]; other site 634500000333 GAF domain; Region: GAF; pfam01590 634500000334 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500000335 PAS domain S-box; Region: sensory_box; TIGR00229 634500000336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500000337 putative active site [active] 634500000338 heme pocket [chemical binding]; other site 634500000339 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000341 metal binding site [ion binding]; metal-binding site 634500000342 active site 634500000343 I-site; other site 634500000344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000345 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 634500000346 active site 634500000347 catalytic residues [active] 634500000348 DNA binding site [nucleotide binding] 634500000349 Int/Topo IB signature motif; other site 634500000350 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 634500000351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500000352 GAF domain; Region: GAF; pfam01590 634500000353 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 634500000354 metal binding site [ion binding]; metal-binding site 634500000355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000356 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500000357 GAF domain; Region: GAF; pfam01590 634500000358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000359 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 634500000360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000361 acetoin reductase; Validated; Region: PRK08643 634500000362 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 634500000363 NAD binding site [chemical binding]; other site 634500000364 homotetramer interface [polypeptide binding]; other site 634500000365 homodimer interface [polypeptide binding]; other site 634500000366 active site 634500000367 substrate binding site [chemical binding]; other site 634500000368 PAS fold; Region: PAS_3; pfam08447 634500000369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500000370 putative CheW interface [polypeptide binding]; other site 634500000371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500000372 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 634500000373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 634500000374 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 634500000375 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 634500000376 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500000377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500000378 metal binding site [ion binding]; metal-binding site 634500000379 active site 634500000380 I-site; other site 634500000381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500000382 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 634500000383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500000384 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634500000385 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 634500000386 putative active site [active] 634500000387 catalytic triad [active] 634500000388 putative dimer interface [polypeptide binding]; other site 634500000389 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 634500000390 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 634500000391 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 634500000392 Helix-turn-helix domain; Region: HTH_38; pfam13936 634500000393 Integrase core domain; Region: rve; pfam00665 634500000394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 634500000395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 634500000396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500000397 AAA domain; Region: AAA_17; pfam13207 634500000398 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500000399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500000400 ABC-ATPase subunit interface; other site 634500000401 dimer interface [polypeptide binding]; other site 634500000402 putative PBP binding regions; other site 634500000403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500000404 ABC-ATPase subunit interface; other site 634500000405 dimer interface [polypeptide binding]; other site 634500000406 putative PBP binding regions; other site 634500000407 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500000408 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634500000409 intersubunit interface [polypeptide binding]; other site 634500000410 Secretin and TonB N terminus short domain; Region: STN; smart00965 634500000411 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 634500000412 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500000413 N-terminal plug; other site 634500000414 ligand-binding site [chemical binding]; other site 634500000415 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 634500000416 FecR protein; Region: FecR; pfam04773 634500000417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500000418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500000419 DNA binding residues [nucleotide binding] 634500000420 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 634500000421 ParB-like nuclease domain; Region: ParB; smart00470 634500000422 ParB family; Region: ParB; pfam08775 634500000423 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 634500000424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500000425 P-loop; other site 634500000426 Magnesium ion binding site [ion binding]; other site 634500000427 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500000428 Magnesium ion binding site [ion binding]; other site 634500000429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 634500000430 Integrase core domain; Region: rve; pfam00665 634500000431 Integrase core domain; Region: rve_3; pfam13683 634500000432 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 634500000433 toxin MazF; Provisional; Region: PRK09907 634500000434 ParA-like protein; Provisional; Region: PHA02518 634500000435 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500000436 P-loop; other site 634500000437 Magnesium ion binding site [ion binding]; other site 634500000438 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 634500000439 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 634500000440 active site 634500000441 DNA binding site [nucleotide binding] 634500000442 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 634500000443 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 634500000444 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500000445 Catalytic site [active] 634500000446 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 634500000447 Helix-turn-helix domain; Region: HTH_38; pfam13936 634500000448 Homeodomain-like domain; Region: HTH_32; pfam13565 634500000449 Integrase core domain; Region: rve; pfam00665 634500000450 Chorismate mutase type II; Region: CM_2; smart00830 634500000451 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 634500000452 Cupin; Region: Cupin_6; pfam12852 634500000453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500000454 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500000455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500000456 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 634500000457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500000458 putative substrate translocation pore; other site 634500000459 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 634500000460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634500000461 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 634500000462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500000463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500000464 putative methylase; Provisional; Region: PRK13699 634500000465 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 634500000466 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 634500000467 Antirestriction protein; Region: Antirestrict; pfam03230 634500000468 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 634500000469 ParB-like nuclease domain; Region: ParBc; cl02129 634500000470 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 634500000471 PsiA protein; Region: PsiA; cl11646 634500000472 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 634500000473 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500000474 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500000475 catalytic residue [active] 634500000476 TraM protein; Region: Tra_M; cl11621 634500000477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634500000478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500000479 ATP binding site [chemical binding]; other site 634500000480 Mg2+ binding site [ion binding]; other site 634500000481 G-X-G motif; other site 634500000482 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 634500000483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500000484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500000485 Coenzyme A binding pocket [chemical binding]; other site 634500000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 634500000487 active site 634500000488 phosphorylation site [posttranslational modification] 634500000489 intermolecular recognition site; other site 634500000490 dimerization interface [polypeptide binding]; other site 634500000491 TraA; Region: TraA; cl11503 634500000492 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 634500000493 TraE protein; Region: TraE; cl05060 634500000494 conjugal transfer protein TraK; Provisional; Region: PRK13736 634500000495 TraK protein; Region: TraK; pfam06586 634500000496 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 634500000497 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 634500000498 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 634500000499 transcriptional activator RfaH; Region: RfaH; TIGR01955 634500000500 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 634500000501 heterodimer interface [polypeptide binding]; other site 634500000502 homodimer interface [polypeptide binding]; other site 634500000503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500000504 conjugal transfer protein TraV; Provisional; Region: PRK13733 634500000505 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 634500000506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500000507 Walker A motif; other site 634500000508 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 634500000509 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 634500000510 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500000511 Walker A motif; other site 634500000512 ATP binding site [chemical binding]; other site 634500000513 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 634500000514 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 634500000515 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 634500000516 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 634500000517 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 634500000518 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 634500000519 F plasmid transfer operon protein; Region: TraF; pfam13728 634500000520 conjugal transfer protein TrbB; Provisional; Region: PRK13728 634500000521 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 634500000522 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 634500000523 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 634500000524 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 634500000525 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 634500000526 F sex factor protein N terminal; Region: TraD_N; pfam12615 634500000527 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500000528 Walker A motif; other site 634500000529 ATP binding site [chemical binding]; other site 634500000530 Walker B motif; other site 634500000531 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 634500000532 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 634500000533 AAA domain; Region: AAA_30; pfam13604 634500000534 DNA helicase TraI; Region: TraI; pfam07057 634500000535 Haemolysin expression modulating protein; Region: HHA; pfam05321 634500000536 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 634500000537 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 634500000538 catalytic residues [active] 634500000539 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 634500000540 PLD-like domain; Region: PLDc_2; pfam13091 634500000541 putative active site [active] 634500000542 catalytic site [active] 634500000543 FMN-binding protein MioC; Provisional; Region: PRK09004 634500000544 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 634500000545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500000546 putative DNA binding site [nucleotide binding]; other site 634500000547 putative Zn2+ binding site [ion binding]; other site 634500000548 AsnC family; Region: AsnC_trans_reg; pfam01037 634500000549 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 634500000550 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 634500000551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634500000552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500000553 S-adenosylmethionine binding site [chemical binding]; other site 634500000554 hypothetical protein; Provisional; Region: yieM; PRK10997 634500000555 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 634500000556 metal ion-dependent adhesion site (MIDAS); other site 634500000557 regulatory ATPase RavA; Provisional; Region: PRK13531 634500000558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500000559 Walker A motif; other site 634500000560 ATP binding site [chemical binding]; other site 634500000561 Walker B motif; other site 634500000562 arginine finger; other site 634500000563 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 634500000564 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 634500000565 potassium uptake protein; Region: kup; TIGR00794 634500000566 sensor protein QseC; Provisional; Region: PRK10337 634500000567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500000568 dimer interface [polypeptide binding]; other site 634500000569 phosphorylation site [posttranslational modification] 634500000570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500000571 ATP binding site [chemical binding]; other site 634500000572 Mg2+ binding site [ion binding]; other site 634500000573 G-X-G motif; other site 634500000574 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 634500000575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500000576 active site 634500000577 phosphorylation site [posttranslational modification] 634500000578 intermolecular recognition site; other site 634500000579 dimerization interface [polypeptide binding]; other site 634500000580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500000581 DNA binding site [nucleotide binding] 634500000582 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 634500000583 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 634500000584 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 634500000585 active site 634500000586 putative substrate binding pocket [chemical binding]; other site 634500000587 xanthine permease; Region: pbuX; TIGR03173 634500000588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500000589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500000590 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 634500000591 putative dimerization interface [polypeptide binding]; other site 634500000592 putative substrate binding pocket [chemical binding]; other site 634500000593 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 634500000594 acetolactate synthase; Reviewed; Region: PRK08617 634500000595 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634500000596 PYR/PP interface [polypeptide binding]; other site 634500000597 dimer interface [polypeptide binding]; other site 634500000598 TPP binding site [chemical binding]; other site 634500000599 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500000600 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 634500000601 TPP-binding site [chemical binding]; other site 634500000602 D-ribose pyranase; Provisional; Region: PRK11797 634500000603 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 634500000604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500000605 Walker A/P-loop; other site 634500000606 ATP binding site [chemical binding]; other site 634500000607 Q-loop/lid; other site 634500000608 ABC transporter signature motif; other site 634500000609 Walker B; other site 634500000610 D-loop; other site 634500000611 H-loop/switch region; other site 634500000612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500000613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500000614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500000615 TM-ABC transporter signature motif; other site 634500000616 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 634500000617 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 634500000618 ligand binding site [chemical binding]; other site 634500000619 dimerization interface [polypeptide binding]; other site 634500000620 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500000621 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 634500000622 substrate binding site [chemical binding]; other site 634500000623 dimer interface [polypeptide binding]; other site 634500000624 ATP binding site [chemical binding]; other site 634500000625 transcriptional repressor RbsR; Provisional; Region: PRK10423 634500000626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500000627 DNA binding site [nucleotide binding] 634500000628 domain linker motif; other site 634500000629 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 634500000630 dimerization interface [polypeptide binding]; other site 634500000631 ligand binding site [chemical binding]; other site 634500000632 putative transporter; Provisional; Region: PRK10504 634500000633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500000634 putative substrate translocation pore; other site 634500000635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500000636 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 634500000637 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 634500000638 GTP binding site; other site 634500000639 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 634500000640 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 634500000641 serine/threonine protein kinase; Provisional; Region: PRK11768 634500000642 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 634500000643 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 634500000644 catalytic residues [active] 634500000645 hinge region; other site 634500000646 alpha helical domain; other site 634500000647 DNA polymerase I; Provisional; Region: PRK05755 634500000648 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 634500000649 active site 634500000650 metal binding site 1 [ion binding]; metal-binding site 634500000651 putative 5' ssDNA interaction site; other site 634500000652 metal binding site 3; metal-binding site 634500000653 metal binding site 2 [ion binding]; metal-binding site 634500000654 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 634500000655 putative DNA binding site [nucleotide binding]; other site 634500000656 putative metal binding site [ion binding]; other site 634500000657 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 634500000658 active site 634500000659 catalytic site [active] 634500000660 substrate binding site [chemical binding]; other site 634500000661 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 634500000662 active site 634500000663 DNA binding site [nucleotide binding] 634500000664 catalytic site [active] 634500000665 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 634500000666 G1 box; other site 634500000667 GTP/Mg2+ binding site [chemical binding]; other site 634500000668 Switch I region; other site 634500000669 G2 box; other site 634500000670 G3 box; other site 634500000671 Switch II region; other site 634500000672 G4 box; other site 634500000673 G5 box; other site 634500000674 Der GTPase activator; Provisional; Region: PRK05244 634500000675 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 634500000676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500000677 FeS/SAM binding site; other site 634500000678 HemN C-terminal domain; Region: HemN_C; pfam06969 634500000679 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 634500000680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500000681 active site 634500000682 phosphorylation site [posttranslational modification] 634500000683 intermolecular recognition site; other site 634500000684 dimerization interface [polypeptide binding]; other site 634500000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500000686 Walker A motif; other site 634500000687 ATP binding site [chemical binding]; other site 634500000688 Walker B motif; other site 634500000689 arginine finger; other site 634500000690 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 634500000691 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 634500000692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500000693 dimer interface [polypeptide binding]; other site 634500000694 phosphorylation site [posttranslational modification] 634500000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500000696 ATP binding site [chemical binding]; other site 634500000697 Mg2+ binding site [ion binding]; other site 634500000698 G-X-G motif; other site 634500000699 glutamine synthetase; Provisional; Region: glnA; PRK09469 634500000700 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 634500000701 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 634500000702 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 634500000703 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 634500000704 G1 box; other site 634500000705 putative GEF interaction site [polypeptide binding]; other site 634500000706 GTP/Mg2+ binding site [chemical binding]; other site 634500000707 Switch I region; other site 634500000708 G2 box; other site 634500000709 G3 box; other site 634500000710 Switch II region; other site 634500000711 G4 box; other site 634500000712 G5 box; other site 634500000713 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 634500000714 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 634500000715 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 634500000716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500000717 motif II; other site 634500000718 hypothetical protein; Reviewed; Region: PRK01637 634500000719 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 634500000720 putative active site [active] 634500000721 dimerization interface [polypeptide binding]; other site 634500000722 putative tRNAtyr binding site [nucleotide binding]; other site 634500000723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500000724 Coenzyme A binding pocket [chemical binding]; other site 634500000725 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 634500000726 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 634500000727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500000728 RNA binding surface [nucleotide binding]; other site 634500000729 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 634500000730 probable active site [active] 634500000731 AsmA family; Region: AsmA; pfam05170 634500000732 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 634500000733 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 634500000734 NADH(P)-binding; Region: NAD_binding_10; pfam13460 634500000735 NAD(P) binding site [chemical binding]; other site 634500000736 putative active site [active] 634500000737 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 634500000738 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 634500000739 generic binding surface II; other site 634500000740 ssDNA binding site; other site 634500000741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500000742 ATP binding site [chemical binding]; other site 634500000743 putative Mg++ binding site [ion binding]; other site 634500000744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500000745 nucleotide binding region [chemical binding]; other site 634500000746 ATP-binding site [chemical binding]; other site 634500000747 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 634500000748 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634500000749 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 634500000750 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 634500000751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500000752 Zn2+ binding site [ion binding]; other site 634500000753 Mg2+ binding site [ion binding]; other site 634500000754 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 634500000755 synthetase active site [active] 634500000756 NTP binding site [chemical binding]; other site 634500000757 metal binding site [ion binding]; metal-binding site 634500000758 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 634500000759 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 634500000760 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 634500000761 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 634500000762 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 634500000763 catalytic site [active] 634500000764 G-X2-G-X-G-K; other site 634500000765 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 634500000766 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 634500000767 nucleotide binding pocket [chemical binding]; other site 634500000768 K-X-D-G motif; other site 634500000769 catalytic site [active] 634500000770 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 634500000771 Predicted membrane protein [Function unknown]; Region: COG2860 634500000772 UPF0126 domain; Region: UPF0126; pfam03458 634500000773 UPF0126 domain; Region: UPF0126; pfam03458 634500000774 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 634500000775 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 634500000776 conserved cys residue [active] 634500000777 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 634500000778 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 634500000779 PhnA protein; Region: PhnA; pfam03831 634500000780 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 634500000781 putative symporter YagG; Provisional; Region: PRK09669 634500000782 alpha-glucosidase; Provisional; Region: PRK10426 634500000783 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 634500000784 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 634500000785 putative active site [active] 634500000786 putative catalytic site [active] 634500000787 hypothetical protein; Provisional; Region: PRK11820 634500000788 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 634500000789 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 634500000790 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 634500000791 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 634500000792 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 634500000793 Nucleoside recognition; Region: Gate; pfam07670 634500000794 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 634500000795 ribonuclease PH; Reviewed; Region: rph; PRK00173 634500000796 Ribonuclease PH; Region: RNase_PH_bact; cd11362 634500000797 hexamer interface [polypeptide binding]; other site 634500000798 active site 634500000799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500000800 active site 634500000801 division inhibitor protein; Provisional; Region: slmA; PRK09480 634500000802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500000803 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 634500000804 trimer interface [polypeptide binding]; other site 634500000805 active site 634500000806 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 634500000807 Flavoprotein; Region: Flavoprotein; pfam02441 634500000808 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 634500000809 hypothetical protein; Reviewed; Region: PRK00024 634500000810 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 634500000811 MPN+ (JAMM) motif; other site 634500000812 Zinc-binding site [ion binding]; other site 634500000813 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 634500000814 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 634500000815 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 634500000816 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 634500000817 DNA binding site [nucleotide binding] 634500000818 catalytic residue [active] 634500000819 H2TH interface [polypeptide binding]; other site 634500000820 putative catalytic residues [active] 634500000821 turnover-facilitating residue; other site 634500000822 intercalation triad [nucleotide binding]; other site 634500000823 8OG recognition residue [nucleotide binding]; other site 634500000824 putative reading head residues; other site 634500000825 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 634500000826 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 634500000827 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 634500000828 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 634500000829 active site 634500000830 (T/H)XGH motif; other site 634500000831 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500000832 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 634500000833 putative metal binding site; other site 634500000834 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 634500000835 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 634500000836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634500000837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500000838 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 634500000839 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 634500000840 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 634500000841 putative active site [active] 634500000842 putative glycosyl transferase; Provisional; Region: PRK10073 634500000843 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500000844 active site 634500000845 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 634500000846 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 634500000847 putative active site [active] 634500000848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500000849 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 634500000850 putative ADP-binding pocket [chemical binding]; other site 634500000851 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 634500000852 putative active site [active] 634500000853 putative catalytic site [active] 634500000854 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 634500000855 O-Antigen ligase; Region: Wzy_C; pfam04932 634500000856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500000857 active site 634500000858 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 634500000859 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 634500000860 putative active site [active] 634500000861 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 634500000862 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 634500000863 putative active site [active] 634500000864 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 634500000865 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 634500000866 NADP binding site [chemical binding]; other site 634500000867 homopentamer interface [polypeptide binding]; other site 634500000868 substrate binding site [chemical binding]; other site 634500000869 active site 634500000870 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 634500000871 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 634500000872 substrate-cofactor binding pocket; other site 634500000873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500000874 catalytic residue [active] 634500000875 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 634500000876 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 634500000877 NAD(P) binding site [chemical binding]; other site 634500000878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500000879 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 634500000880 putative ADP-binding pocket [chemical binding]; other site 634500000881 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 634500000882 NodB motif; other site 634500000883 putative active site [active] 634500000884 putative catalytic site [active] 634500000885 Zn binding site [ion binding]; other site 634500000886 AmiB activator; Provisional; Region: PRK11637 634500000887 Peptidase family M23; Region: Peptidase_M23; pfam01551 634500000888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634500000889 active site residue [active] 634500000890 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 634500000891 SecA binding site; other site 634500000892 Preprotein binding site; other site 634500000893 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 634500000894 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 634500000895 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 634500000896 serine acetyltransferase; Provisional; Region: cysE; PRK11132 634500000897 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 634500000898 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 634500000899 trimer interface [polypeptide binding]; other site 634500000900 active site 634500000901 substrate binding site [chemical binding]; other site 634500000902 CoA binding site [chemical binding]; other site 634500000903 putative rRNA methylase; Provisional; Region: PRK10358 634500000904 two-component sensor protein; Provisional; Region: cpxA; PRK09470 634500000905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500000906 dimerization interface [polypeptide binding]; other site 634500000907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500000908 dimer interface [polypeptide binding]; other site 634500000909 phosphorylation site [posttranslational modification] 634500000910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500000911 ATP binding site [chemical binding]; other site 634500000912 Mg2+ binding site [ion binding]; other site 634500000913 G-X-G motif; other site 634500000914 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 634500000915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500000916 active site 634500000917 intermolecular recognition site; other site 634500000918 dimerization interface [polypeptide binding]; other site 634500000919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500000920 DNA binding site [nucleotide binding] 634500000921 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 634500000922 dimer interface [polypeptide binding]; other site 634500000923 integrase; Provisional; Region: int; PHA02601 634500000924 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634500000925 active site 634500000926 DNA binding site [nucleotide binding] 634500000927 Int/Topo IB signature motif; other site 634500000928 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 634500000929 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 634500000930 DksA-like zinc finger domain containing protein; Region: PHA00080 634500000931 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 634500000932 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 634500000933 Domain of unknown function (DUF955); Region: DUF955; pfam06114 634500000934 Phage-related protein [Function unknown]; Region: COG4695; cl01923 634500000935 Phage portal protein; Region: Phage_portal; pfam04860 634500000936 Terminase-like family; Region: Terminase_6; pfam03237 634500000937 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 634500000938 capsid protein; Provisional; Region: N; PHA02538 634500000939 terminase endonuclease subunit; Provisional; Region: M; PHA02537 634500000940 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 634500000941 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 634500000942 Phage Tail Protein X; Region: Phage_tail_X; cl02088 634500000943 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 634500000944 catalytic residues [active] 634500000945 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 634500000946 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 634500000947 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 634500000948 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 634500000949 Baseplate J-like protein; Region: Baseplate_J; cl01294 634500000950 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 634500000951 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 634500000952 Phage Tail Collar Domain; Region: Collar; pfam07484 634500000953 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 634500000954 Phage protein U [General function prediction only]; Region: COG3499 634500000955 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 634500000956 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 634500000957 Phage tail tube protein FII; Region: Phage_tube; pfam04985 634500000958 major tail sheath protein; Provisional; Region: FI; PHA02560 634500000959 tail protein; Provisional; Region: D; PHA02561 634500000960 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 634500000961 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 634500000962 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 634500000963 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 634500000964 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 634500000965 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 634500000966 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 634500000967 active site 634500000968 ADP/pyrophosphate binding site [chemical binding]; other site 634500000969 dimerization interface [polypeptide binding]; other site 634500000970 allosteric effector site; other site 634500000971 fructose-1,6-bisphosphate binding site; other site 634500000972 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 634500000973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500000974 membrane-bound complex binding site; other site 634500000975 hinge residues; other site 634500000976 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 634500000977 inner membrane protein YhjD; Region: TIGR00766 634500000978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500000979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500000980 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 634500000981 putative effector binding pocket; other site 634500000982 putative dimerization interface [polypeptide binding]; other site 634500000983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634500000984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500000985 NAD(P) binding site [chemical binding]; other site 634500000986 active site 634500000987 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 634500000988 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 634500000989 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 634500000990 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 634500000991 putative C-terminal domain interface [polypeptide binding]; other site 634500000992 putative GSH binding site (G-site) [chemical binding]; other site 634500000993 putative dimer interface [polypeptide binding]; other site 634500000994 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 634500000995 putative N-terminal domain interface [polypeptide binding]; other site 634500000996 putative dimer interface [polypeptide binding]; other site 634500000997 putative substrate binding pocket (H-site) [chemical binding]; other site 634500000998 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500000999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500001000 DNA-binding site [nucleotide binding]; DNA binding site 634500001001 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500001002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001003 homodimer interface [polypeptide binding]; other site 634500001004 catalytic residue [active] 634500001005 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634500001006 malate:quinone oxidoreductase; Validated; Region: PRK05257 634500001007 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 634500001008 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 634500001009 Uncharacterized conserved protein [Function unknown]; Region: COG2128 634500001010 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500001011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500001012 DNA-binding site [nucleotide binding]; DNA binding site 634500001013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500001014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001015 homodimer interface [polypeptide binding]; other site 634500001016 catalytic residue [active] 634500001017 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 634500001018 triosephosphate isomerase; Provisional; Region: PRK14567 634500001019 substrate binding site [chemical binding]; other site 634500001020 dimer interface [polypeptide binding]; other site 634500001021 catalytic triad [active] 634500001022 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 634500001023 Predicted membrane protein [Function unknown]; Region: COG3152 634500001024 ferredoxin-NADP reductase; Provisional; Region: PRK10926 634500001025 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 634500001026 FAD binding pocket [chemical binding]; other site 634500001027 FAD binding motif [chemical binding]; other site 634500001028 phosphate binding motif [ion binding]; other site 634500001029 beta-alpha-beta structure motif; other site 634500001030 NAD binding pocket [chemical binding]; other site 634500001031 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 634500001032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001033 putative substrate translocation pore; other site 634500001034 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 634500001035 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 634500001036 putative active site [active] 634500001037 glycerol kinase; Provisional; Region: glpK; PRK00047 634500001038 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 634500001039 N- and C-terminal domain interface [polypeptide binding]; other site 634500001040 active site 634500001041 MgATP binding site [chemical binding]; other site 634500001042 catalytic site [active] 634500001043 metal binding site [ion binding]; metal-binding site 634500001044 glycerol binding site [chemical binding]; other site 634500001045 homotetramer interface [polypeptide binding]; other site 634500001046 homodimer interface [polypeptide binding]; other site 634500001047 FBP binding site [chemical binding]; other site 634500001048 protein IIAGlc interface [polypeptide binding]; other site 634500001049 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 634500001050 amphipathic channel; other site 634500001051 Asn-Pro-Ala signature motifs; other site 634500001052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 634500001053 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 634500001054 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 634500001055 UbiA prenyltransferase family; Region: UbiA; pfam01040 634500001056 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 634500001057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500001058 Walker A motif; other site 634500001059 ATP binding site [chemical binding]; other site 634500001060 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 634500001061 Walker B motif; other site 634500001062 arginine finger; other site 634500001063 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634500001064 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 634500001065 active site 634500001066 HslU subunit interaction site [polypeptide binding]; other site 634500001067 cell division protein FtsN; Provisional; Region: PRK12757 634500001068 Sporulation related domain; Region: SPOR; cl10051 634500001069 Sporulation related domain; Region: SPOR; cl10051 634500001070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500001071 DNA binding site [nucleotide binding] 634500001072 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 634500001073 domain linker motif; other site 634500001074 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 634500001075 dimerization interface [polypeptide binding]; other site 634500001076 ligand binding site [chemical binding]; other site 634500001077 primosome assembly protein PriA; Validated; Region: PRK05580 634500001078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500001079 ATP binding site [chemical binding]; other site 634500001080 putative Mg++ binding site [ion binding]; other site 634500001081 helicase superfamily c-terminal domain; Region: HELICc; smart00490 634500001082 ATP-binding site [chemical binding]; other site 634500001083 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 634500001084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500001085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001086 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500001087 putative effector binding pocket; other site 634500001088 putative dimerization interface [polypeptide binding]; other site 634500001089 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500001090 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500001091 active site 634500001092 catalytic tetrad [active] 634500001093 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 634500001094 dimerization interface [polypeptide binding]; other site 634500001095 DNA binding site [nucleotide binding] 634500001096 corepressor binding sites; other site 634500001097 cystathionine gamma-synthase; Provisional; Region: PRK08045 634500001098 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634500001099 homodimer interface [polypeptide binding]; other site 634500001100 substrate-cofactor binding pocket; other site 634500001101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001102 catalytic residue [active] 634500001103 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 634500001104 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 634500001105 putative catalytic residues [active] 634500001106 putative nucleotide binding site [chemical binding]; other site 634500001107 putative aspartate binding site [chemical binding]; other site 634500001108 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 634500001109 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 634500001110 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 634500001111 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 634500001112 FAD binding site [chemical binding]; other site 634500001113 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 634500001114 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 634500001115 acetylornithine deacetylase; Provisional; Region: PRK05111 634500001116 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 634500001117 metal binding site [ion binding]; metal-binding site 634500001118 putative dimer interface [polypeptide binding]; other site 634500001119 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 634500001120 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634500001121 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 634500001122 nucleotide binding site [chemical binding]; other site 634500001123 N-acetyl-L-glutamate binding site [chemical binding]; other site 634500001124 argininosuccinate synthase; Provisional; Region: PRK13820 634500001125 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 634500001126 ANP binding site [chemical binding]; other site 634500001127 Substrate Binding Site II [chemical binding]; other site 634500001128 Substrate Binding Site I [chemical binding]; other site 634500001129 argininosuccinate lyase; Provisional; Region: PRK04833 634500001130 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 634500001131 active sites [active] 634500001132 tetramer interface [polypeptide binding]; other site 634500001133 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 634500001134 catalytic triad [active] 634500001135 dimer interface [polypeptide binding]; other site 634500001136 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 634500001137 GSH binding site [chemical binding]; other site 634500001138 catalytic residues [active] 634500001139 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 634500001140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001141 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 634500001142 dimerization interface [polypeptide binding]; other site 634500001143 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 634500001144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500001145 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634500001146 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 634500001147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500001148 hypothetical protein; Provisional; Region: PRK11056 634500001149 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 634500001150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500001151 S-adenosylmethionine binding site [chemical binding]; other site 634500001152 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 634500001153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500001154 N-terminal plug; other site 634500001155 ligand-binding site [chemical binding]; other site 634500001156 glutamate racemase; Provisional; Region: PRK00865 634500001157 transcriptional regulator HdfR; Provisional; Region: PRK03601 634500001158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500001160 dimerization interface [polypeptide binding]; other site 634500001161 hypothetical protein; Provisional; Region: PRK11027 634500001162 putative ATP-dependent protease; Provisional; Region: PRK09862 634500001163 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 634500001164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500001165 Walker A motif; other site 634500001166 ATP binding site [chemical binding]; other site 634500001167 Walker B motif; other site 634500001168 arginine finger; other site 634500001169 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 634500001170 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 634500001171 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634500001172 PYR/PP interface [polypeptide binding]; other site 634500001173 dimer interface [polypeptide binding]; other site 634500001174 TPP binding site [chemical binding]; other site 634500001175 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500001176 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 634500001177 TPP-binding site [chemical binding]; other site 634500001178 dimer interface [polypeptide binding]; other site 634500001179 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 634500001180 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 634500001181 homodimer interface [polypeptide binding]; other site 634500001182 substrate-cofactor binding pocket; other site 634500001183 catalytic residue [active] 634500001184 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 634500001185 threonine dehydratase; Reviewed; Region: PRK09224 634500001186 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 634500001187 tetramer interface [polypeptide binding]; other site 634500001188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001189 catalytic residue [active] 634500001190 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 634500001191 putative Ile/Val binding site [chemical binding]; other site 634500001192 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 634500001193 putative Ile/Val binding site [chemical binding]; other site 634500001194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001195 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 634500001196 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 634500001197 putative dimerization interface [polypeptide binding]; other site 634500001198 ketol-acid reductoisomerase; Validated; Region: PRK05225 634500001199 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 634500001200 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 634500001201 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 634500001202 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 634500001203 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 634500001204 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 634500001205 Part of AAA domain; Region: AAA_19; pfam13245 634500001206 Family description; Region: UvrD_C_2; pfam13538 634500001207 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 634500001208 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 634500001209 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 634500001210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634500001211 ATP binding site [chemical binding]; other site 634500001212 Mg++ binding site [ion binding]; other site 634500001213 motif III; other site 634500001214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500001215 nucleotide binding region [chemical binding]; other site 634500001216 ATP-binding site [chemical binding]; other site 634500001217 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634500001218 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634500001219 catalytic residues [active] 634500001220 transcription termination factor Rho; Provisional; Region: rho; PRK09376 634500001221 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 634500001222 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 634500001223 RNA binding site [nucleotide binding]; other site 634500001224 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 634500001225 multimer interface [polypeptide binding]; other site 634500001226 Walker A motif; other site 634500001227 ATP binding site [chemical binding]; other site 634500001228 Walker B motif; other site 634500001229 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 634500001230 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 634500001231 Mg++ binding site [ion binding]; other site 634500001232 putative catalytic motif [active] 634500001233 substrate binding site [chemical binding]; other site 634500001234 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 634500001235 Chain length determinant protein; Region: Wzz; pfam02706 634500001236 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 634500001237 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 634500001238 active site 634500001239 homodimer interface [polypeptide binding]; other site 634500001240 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 634500001241 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634500001242 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 634500001243 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 634500001244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500001245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500001246 Coenzyme A binding pocket [chemical binding]; other site 634500001247 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 634500001248 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 634500001249 inhibitor-cofactor binding pocket; inhibition site 634500001250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001251 catalytic residue [active] 634500001252 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634500001253 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 634500001254 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 634500001255 putative common antigen polymerase; Provisional; Region: PRK02975 634500001256 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 634500001257 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 634500001258 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 634500001259 HemY protein N-terminus; Region: HemY_N; pfam07219 634500001260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500001261 TPR motif; other site 634500001262 binding surface 634500001263 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 634500001264 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 634500001265 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 634500001266 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 634500001267 active site 634500001268 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 634500001269 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 634500001270 domain interfaces; other site 634500001271 active site 634500001272 adenylate cyclase; Provisional; Region: cyaA; PRK09450 634500001273 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 634500001274 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 634500001275 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 634500001276 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 634500001277 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 634500001278 hypothetical protein; Provisional; Region: PRK10963 634500001279 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 634500001280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634500001281 active site 634500001282 DNA binding site [nucleotide binding] 634500001283 Int/Topo IB signature motif; other site 634500001284 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 634500001285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500001286 motif II; other site 634500001287 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 634500001288 Part of AAA domain; Region: AAA_19; pfam13245 634500001289 Family description; Region: UvrD_C_2; pfam13538 634500001290 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 634500001291 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 634500001292 Cl binding site [ion binding]; other site 634500001293 oligomer interface [polypeptide binding]; other site 634500001294 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 634500001295 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 634500001296 CoenzymeA binding site [chemical binding]; other site 634500001297 subunit interaction site [polypeptide binding]; other site 634500001298 PHB binding site; other site 634500001299 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 634500001300 dimerization interface [polypeptide binding]; other site 634500001301 substrate binding site [chemical binding]; other site 634500001302 active site 634500001303 calcium binding site [ion binding]; other site 634500001304 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 634500001305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500001306 ATP binding site [chemical binding]; other site 634500001307 putative Mg++ binding site [ion binding]; other site 634500001308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500001309 nucleotide binding region [chemical binding]; other site 634500001310 ATP-binding site [chemical binding]; other site 634500001311 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 634500001312 HRDC domain; Region: HRDC; pfam00570 634500001313 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 634500001314 lysophospholipase L2; Provisional; Region: PRK10749 634500001315 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500001316 putative hydrolase; Provisional; Region: PRK10976 634500001317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500001318 active site 634500001319 motif I; other site 634500001320 motif II; other site 634500001321 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 634500001322 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634500001323 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 634500001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001325 putative substrate translocation pore; other site 634500001326 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634500001327 EamA-like transporter family; Region: EamA; pfam00892 634500001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 634500001329 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 634500001330 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 634500001331 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 634500001332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001333 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 634500001334 putative dimerization interface [polypeptide binding]; other site 634500001335 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 634500001336 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 634500001337 THF binding site; other site 634500001338 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 634500001339 substrate binding site [chemical binding]; other site 634500001340 THF binding site; other site 634500001341 zinc-binding site [ion binding]; other site 634500001342 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 634500001343 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 634500001344 uridine phosphorylase; Provisional; Region: PRK11178 634500001345 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 634500001346 DNA recombination protein RmuC; Provisional; Region: PRK10361 634500001347 RmuC family; Region: RmuC; pfam02646 634500001348 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 634500001349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500001350 S-adenosylmethionine binding site [chemical binding]; other site 634500001351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 634500001352 SCP-2 sterol transfer family; Region: SCP2; pfam02036 634500001353 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 634500001354 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 634500001355 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 634500001356 sec-independent translocase; Provisional; Region: PRK01770 634500001357 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 634500001358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 634500001359 active site 634500001360 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 634500001361 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 634500001362 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 634500001363 FMN reductase; Validated; Region: fre; PRK08051 634500001364 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 634500001365 FAD binding pocket [chemical binding]; other site 634500001366 FAD binding motif [chemical binding]; other site 634500001367 phosphate binding motif [ion binding]; other site 634500001368 beta-alpha-beta structure motif; other site 634500001369 NAD binding pocket [chemical binding]; other site 634500001370 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 634500001371 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634500001372 dimer interface [polypeptide binding]; other site 634500001373 active site 634500001374 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 634500001375 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634500001376 substrate binding site [chemical binding]; other site 634500001377 oxyanion hole (OAH) forming residues; other site 634500001378 trimer interface [polypeptide binding]; other site 634500001379 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634500001380 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634500001381 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634500001382 proline dipeptidase; Provisional; Region: PRK13607 634500001383 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 634500001384 active site 634500001385 hypothetical protein; Provisional; Region: PRK11568 634500001386 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 634500001387 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 634500001388 potassium transporter; Provisional; Region: PRK10750 634500001389 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 634500001390 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 634500001391 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 634500001392 FAD binding domain; Region: FAD_binding_4; pfam01565 634500001393 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 634500001394 Biotin operon repressor [Transcription]; Region: BirA; COG1654 634500001395 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 634500001396 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 634500001397 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 634500001398 pantothenate kinase; Provisional; Region: PRK05439 634500001399 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 634500001400 ATP-binding site [chemical binding]; other site 634500001401 CoA-binding site [chemical binding]; other site 634500001402 Mg2+-binding site [ion binding]; other site 634500001403 elongation factor Tu; Reviewed; Region: PRK00049 634500001404 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 634500001405 G1 box; other site 634500001406 GEF interaction site [polypeptide binding]; other site 634500001407 GTP/Mg2+ binding site [chemical binding]; other site 634500001408 Switch I region; other site 634500001409 G2 box; other site 634500001410 G3 box; other site 634500001411 Switch II region; other site 634500001412 G4 box; other site 634500001413 G5 box; other site 634500001414 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 634500001415 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 634500001416 Antibiotic Binding Site [chemical binding]; other site 634500001417 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 634500001418 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 634500001419 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 634500001420 putative homodimer interface [polypeptide binding]; other site 634500001421 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 634500001422 heterodimer interface [polypeptide binding]; other site 634500001423 homodimer interface [polypeptide binding]; other site 634500001424 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 634500001425 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 634500001426 23S rRNA interface [nucleotide binding]; other site 634500001427 L7/L12 interface [polypeptide binding]; other site 634500001428 putative thiostrepton binding site; other site 634500001429 L25 interface [polypeptide binding]; other site 634500001430 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 634500001431 mRNA/rRNA interface [nucleotide binding]; other site 634500001432 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 634500001433 23S rRNA interface [nucleotide binding]; other site 634500001434 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 634500001435 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 634500001436 core dimer interface [polypeptide binding]; other site 634500001437 peripheral dimer interface [polypeptide binding]; other site 634500001438 L10 interface [polypeptide binding]; other site 634500001439 L11 interface [polypeptide binding]; other site 634500001440 putative EF-Tu interaction site [polypeptide binding]; other site 634500001441 putative EF-G interaction site [polypeptide binding]; other site 634500001442 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 634500001443 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 634500001444 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 634500001445 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 634500001446 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 634500001447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 634500001448 RPB3 interaction site [polypeptide binding]; other site 634500001449 RPB1 interaction site [polypeptide binding]; other site 634500001450 RPB11 interaction site [polypeptide binding]; other site 634500001451 RPB10 interaction site [polypeptide binding]; other site 634500001452 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 634500001453 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 634500001454 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 634500001455 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 634500001456 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 634500001457 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 634500001458 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 634500001459 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 634500001460 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 634500001461 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 634500001462 DNA binding site [nucleotide binding] 634500001463 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 634500001464 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 634500001465 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500001466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500001467 DNA-binding site [nucleotide binding]; DNA binding site 634500001468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500001469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001470 homodimer interface [polypeptide binding]; other site 634500001471 catalytic residue [active] 634500001472 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 634500001473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500001474 FeS/SAM binding site; other site 634500001475 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 634500001476 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 634500001477 ThiS interaction site; other site 634500001478 putative active site [active] 634500001479 tetramer interface [polypeptide binding]; other site 634500001480 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 634500001481 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 634500001482 ATP binding site [chemical binding]; other site 634500001483 substrate interface [chemical binding]; other site 634500001484 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 634500001485 thiamine phosphate binding site [chemical binding]; other site 634500001486 active site 634500001487 pyrophosphate binding site [ion binding]; other site 634500001488 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 634500001489 ThiC-associated domain; Region: ThiC-associated; pfam13667 634500001490 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 634500001491 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 634500001492 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 634500001493 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 634500001494 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 634500001495 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 634500001496 putative NADH binding site [chemical binding]; other site 634500001497 putative active site [active] 634500001498 nudix motif; other site 634500001499 putative metal binding site [ion binding]; other site 634500001500 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 634500001501 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 634500001502 substrate binding site [chemical binding]; other site 634500001503 active site 634500001504 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 634500001505 Active_site [active] 634500001506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 634500001507 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 634500001508 IHF dimer interface [polypeptide binding]; other site 634500001509 IHF - DNA interface [nucleotide binding]; other site 634500001510 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 634500001511 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 634500001512 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 634500001513 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 634500001514 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 634500001515 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 634500001516 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 634500001517 purine monophosphate binding site [chemical binding]; other site 634500001518 dimer interface [polypeptide binding]; other site 634500001519 putative catalytic residues [active] 634500001520 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 634500001521 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 634500001522 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 634500001523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500001524 substrate binding pocket [chemical binding]; other site 634500001525 membrane-bound complex binding site; other site 634500001526 hinge residues; other site 634500001527 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 634500001528 amidohydrolase; Region: amidohydrolases; TIGR01891 634500001529 metal binding site [ion binding]; metal-binding site 634500001530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500001531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500001533 dimerization interface [polypeptide binding]; other site 634500001534 homoserine O-succinyltransferase; Provisional; Region: PRK05368 634500001535 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 634500001536 proposed active site lysine [active] 634500001537 conserved cys residue [active] 634500001538 malate synthase A; Region: malate_syn_A; TIGR01344 634500001539 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 634500001540 active site 634500001541 isocitrate lyase; Provisional; Region: PRK15063 634500001542 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 634500001543 tetramer interface [polypeptide binding]; other site 634500001544 active site 634500001545 Mg2+/Mn2+ binding site [ion binding]; other site 634500001546 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 634500001547 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 634500001548 phosphogluconate dehydratase; Validated; Region: PRK09054 634500001549 6-phosphogluconate dehydratase; Region: edd; TIGR01196 634500001550 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 634500001551 ATP-binding site [chemical binding]; other site 634500001552 Gluconate-6-phosphate binding site [chemical binding]; other site 634500001553 transcriptional repressor IclR; Provisional; Region: PRK11569 634500001554 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 634500001555 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500001556 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 634500001557 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 634500001558 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 634500001559 substrate binding pocket [chemical binding]; other site 634500001560 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 634500001561 B12 binding site [chemical binding]; other site 634500001562 cobalt ligand [ion binding]; other site 634500001563 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 634500001564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500001565 transcriptional regulator protein; Region: phnR; TIGR03337 634500001566 DNA-binding site [nucleotide binding]; DNA binding site 634500001567 UTRA domain; Region: UTRA; pfam07702 634500001568 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500001569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 634500001570 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 634500001571 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 634500001572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500001573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500001574 dimer interface [polypeptide binding]; other site 634500001575 conserved gate region; other site 634500001576 putative PBP binding loops; other site 634500001577 ABC-ATPase subunit interface; other site 634500001578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500001580 dimer interface [polypeptide binding]; other site 634500001581 conserved gate region; other site 634500001582 putative PBP binding loops; other site 634500001583 ABC-ATPase subunit interface; other site 634500001584 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500001585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500001586 Walker A/P-loop; other site 634500001587 ATP binding site [chemical binding]; other site 634500001588 Q-loop/lid; other site 634500001589 ABC transporter signature motif; other site 634500001590 Walker B; other site 634500001591 D-loop; other site 634500001592 H-loop/switch region; other site 634500001593 TOBE domain; Region: TOBE_2; pfam08402 634500001594 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 634500001595 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 634500001596 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 634500001597 PhoU domain; Region: PhoU; pfam01895 634500001598 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 634500001599 Sodium Bile acid symporter family; Region: SBF; pfam01758 634500001600 aspartate kinase III; Validated; Region: PRK09084 634500001601 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 634500001602 nucleotide binding site [chemical binding]; other site 634500001603 substrate binding site [chemical binding]; other site 634500001604 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 634500001605 lysine allosteric regulatory site; other site 634500001606 dimer interface [polypeptide binding]; other site 634500001607 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 634500001608 dimer interface [polypeptide binding]; other site 634500001609 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 634500001610 TrkA-N domain; Region: TrkA_N; pfam02254 634500001611 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 634500001612 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 634500001613 active site 634500001614 dimer interface [polypeptide binding]; other site 634500001615 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 634500001616 dimer interface [polypeptide binding]; other site 634500001617 active site 634500001618 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 634500001619 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 634500001620 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 634500001621 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 634500001622 Chorismate lyase; Region: Chor_lyase; cl01230 634500001623 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 634500001624 UbiA prenyltransferase family; Region: UbiA; pfam01040 634500001625 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 634500001626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 634500001627 putative acyl-acceptor binding pocket; other site 634500001628 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 634500001629 LexA repressor; Validated; Region: PRK00215 634500001630 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 634500001631 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500001632 Catalytic site [active] 634500001633 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 634500001634 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 634500001635 hypothetical protein; Provisional; Region: PRK10428 634500001636 ferric uptake regulator; Provisional; Region: fur; PRK09462 634500001637 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 634500001638 metal binding site 2 [ion binding]; metal-binding site 634500001639 putative DNA binding helix; other site 634500001640 metal binding site 1 [ion binding]; metal-binding site 634500001641 dimer interface [polypeptide binding]; other site 634500001642 structural Zn2+ binding site [ion binding]; other site 634500001643 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 634500001644 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 634500001645 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 634500001646 FMN binding site [chemical binding]; other site 634500001647 active site 634500001648 catalytic residues [active] 634500001649 substrate binding site [chemical binding]; other site 634500001650 phage shock protein G; Reviewed; Region: pspG; PRK09459 634500001651 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 634500001652 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 634500001653 NADP binding site [chemical binding]; other site 634500001654 dimer interface [polypeptide binding]; other site 634500001655 replicative DNA helicase; Provisional; Region: PRK08006 634500001656 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 634500001657 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 634500001658 Walker A motif; other site 634500001659 ATP binding site [chemical binding]; other site 634500001660 Walker B motif; other site 634500001661 DNA binding loops [nucleotide binding] 634500001662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 634500001663 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 634500001664 putative DNA binding site [nucleotide binding]; other site 634500001665 putative Zn2+ binding site [ion binding]; other site 634500001666 AsnC family; Region: AsnC_trans_reg; pfam01037 634500001667 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634500001668 Uncharacterized conserved protein [Function unknown]; Region: COG1284 634500001669 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 634500001670 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 634500001671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500001672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500001673 homodimer interface [polypeptide binding]; other site 634500001674 catalytic residue [active] 634500001675 Uncharacterized conserved protein [Function unknown]; Region: COG0432 634500001676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 634500001677 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 634500001678 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 634500001679 metal binding site [ion binding]; metal-binding site 634500001680 dimer interface [polypeptide binding]; other site 634500001681 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 634500001682 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 634500001683 active site 634500001684 substrate binding pocket [chemical binding]; other site 634500001685 homodimer interaction site [polypeptide binding]; other site 634500001686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500001687 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500001688 TM-ABC transporter signature motif; other site 634500001689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634500001690 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500001691 Walker A/P-loop; other site 634500001692 ATP binding site [chemical binding]; other site 634500001693 Q-loop/lid; other site 634500001694 ABC transporter signature motif; other site 634500001695 Walker B; other site 634500001696 D-loop; other site 634500001697 H-loop/switch region; other site 634500001698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500001699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500001700 DNA binding site [nucleotide binding] 634500001701 domain linker motif; other site 634500001702 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 634500001703 putative dimerization interface [polypeptide binding]; other site 634500001704 putative ligand binding site [chemical binding]; other site 634500001705 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500001706 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 634500001707 ligand binding site [chemical binding]; other site 634500001708 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500001709 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 634500001710 substrate binding site [chemical binding]; other site 634500001711 dimer interface [polypeptide binding]; other site 634500001712 ATP binding site [chemical binding]; other site 634500001713 BtpA family; Region: BtpA; cl00440 634500001714 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 634500001715 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 634500001716 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634500001717 putative NAD(P) binding site [chemical binding]; other site 634500001718 putative substrate binding site [chemical binding]; other site 634500001719 catalytic Zn binding site [ion binding]; other site 634500001720 structural Zn binding site [ion binding]; other site 634500001721 dimer interface [polypeptide binding]; other site 634500001722 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 634500001723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 634500001724 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 634500001725 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 634500001726 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 634500001727 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 634500001728 dimer interface [polypeptide binding]; other site 634500001729 ssDNA binding site [nucleotide binding]; other site 634500001730 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634500001731 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 634500001732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500001733 N-terminal plug; other site 634500001734 ligand-binding site [chemical binding]; other site 634500001735 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 634500001736 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500001737 siderophore binding site; other site 634500001738 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500001739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500001740 ABC-ATPase subunit interface; other site 634500001741 dimer interface [polypeptide binding]; other site 634500001742 putative PBP binding regions; other site 634500001743 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500001744 ABC-ATPase subunit interface; other site 634500001745 dimer interface [polypeptide binding]; other site 634500001746 putative PBP binding regions; other site 634500001747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500001748 non-specific DNA binding site [nucleotide binding]; other site 634500001749 salt bridge; other site 634500001750 sequence-specific DNA binding site [nucleotide binding]; other site 634500001751 HipA-like N-terminal domain; Region: HipA_N; pfam07805 634500001752 HipA-like C-terminal domain; Region: HipA_C; pfam07804 634500001753 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 634500001754 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 634500001755 active site 634500001756 catalytic site [active] 634500001757 Zn binding site [ion binding]; other site 634500001758 tetramer interface [polypeptide binding]; other site 634500001759 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 634500001760 classical (c) SDRs; Region: SDR_c; cd05233 634500001761 NAD(P) binding site [chemical binding]; other site 634500001762 active site 634500001763 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 634500001764 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634500001765 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 634500001766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001767 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500001768 putative substrate translocation pore; other site 634500001769 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 634500001770 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634500001771 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500001772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500001773 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 634500001774 Protein of unknown function (DUF535); Region: DUF535; pfam04393 634500001775 Transposase; Region: HTH_Tnp_1; pfam01527 634500001776 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634500001777 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 634500001778 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 634500001779 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 634500001780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 634500001781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500001782 metal binding site [ion binding]; metal-binding site 634500001783 active site 634500001784 I-site; other site 634500001785 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 634500001786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500001787 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 634500001788 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 634500001789 DNA binding residues [nucleotide binding] 634500001790 dimer interface [polypeptide binding]; other site 634500001791 [2Fe-2S] cluster binding site [ion binding]; other site 634500001792 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 634500001793 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 634500001794 putative C-terminal domain interface [polypeptide binding]; other site 634500001795 putative GSH binding site (G-site) [chemical binding]; other site 634500001796 putative dimer interface [polypeptide binding]; other site 634500001797 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 634500001798 putative N-terminal domain interface [polypeptide binding]; other site 634500001799 putative dimer interface [polypeptide binding]; other site 634500001800 putative substrate binding pocket (H-site) [chemical binding]; other site 634500001801 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 634500001802 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 634500001803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500001804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001805 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 634500001806 putative dimerization interface [polypeptide binding]; other site 634500001807 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 634500001808 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 634500001809 YfaZ precursor; Region: YfaZ; pfam07437 634500001810 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 634500001811 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 634500001812 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 634500001813 Na binding site [ion binding]; other site 634500001814 Predicted membrane protein [Function unknown]; Region: COG3162 634500001815 acetyl-CoA synthetase; Provisional; Region: PRK00174 634500001816 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 634500001817 active site 634500001818 CoA binding site [chemical binding]; other site 634500001819 acyl-activating enzyme (AAE) consensus motif; other site 634500001820 AMP binding site [chemical binding]; other site 634500001821 acetate binding site [chemical binding]; other site 634500001822 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634500001823 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 634500001824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500001825 PAS domain; Region: PAS_9; pfam13426 634500001826 putative active site [active] 634500001827 heme pocket [chemical binding]; other site 634500001828 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500001829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500001830 dimer interface [polypeptide binding]; other site 634500001831 putative CheW interface [polypeptide binding]; other site 634500001832 Cupin domain; Region: Cupin_2; cl17218 634500001833 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500001834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500001835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500001836 2-isopropylmalate synthase; Validated; Region: PRK03739 634500001837 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 634500001838 active site 634500001839 catalytic residues [active] 634500001840 metal binding site [ion binding]; metal-binding site 634500001841 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 634500001842 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 634500001843 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 634500001844 DAK2 domain; Region: Dak2; pfam02734 634500001845 microcin B17 transporter; Reviewed; Region: PRK11098 634500001846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500001847 PAS domain; Region: PAS_9; pfam13426 634500001848 putative active site [active] 634500001849 heme pocket [chemical binding]; other site 634500001850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500001851 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 634500001852 putative active site [active] 634500001853 heme pocket [chemical binding]; other site 634500001854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500001855 putative active site [active] 634500001856 heme pocket [chemical binding]; other site 634500001857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500001858 putative active site [active] 634500001859 heme pocket [chemical binding]; other site 634500001860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500001861 metal binding site [ion binding]; metal-binding site 634500001862 active site 634500001863 I-site; other site 634500001864 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500001865 benzoate transport; Region: 2A0115; TIGR00895 634500001866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001868 putative substrate translocation pore; other site 634500001869 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634500001870 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500001871 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500001872 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500001873 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500001874 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634500001875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500001876 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 634500001877 dimer interface [polypeptide binding]; other site 634500001878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500001879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500001881 dimerization interface [polypeptide binding]; other site 634500001882 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634500001883 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 634500001884 NAD(P) binding site [chemical binding]; other site 634500001885 active site 634500001886 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 634500001887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500001888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500001889 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500001890 putative effector binding pocket; other site 634500001891 dimerization interface [polypeptide binding]; other site 634500001892 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001894 putative substrate translocation pore; other site 634500001895 trehalase; Provisional; Region: treF; PRK13270 634500001896 Trehalase; Region: Trehalase; cl17346 634500001897 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 634500001898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500001899 substrate binding pocket [chemical binding]; other site 634500001900 membrane-bound complex binding site; other site 634500001901 hinge residues; other site 634500001902 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 634500001903 putative active site [active] 634500001904 Zn binding site [ion binding]; other site 634500001905 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 634500001906 active site pocket [active] 634500001907 oxyanion hole [active] 634500001908 catalytic triad [active] 634500001909 active site nucleophile [active] 634500001910 hypothetical protein; Provisional; Region: PRK10481 634500001911 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 634500001912 OPT oligopeptide transporter protein; Region: OPT; cl14607 634500001913 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634500001914 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 634500001915 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500001916 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 634500001917 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500001918 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500001919 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500001920 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 634500001921 nudix motif; other site 634500001922 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 634500001923 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500001924 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 634500001925 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500001926 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500001927 Cytochrome c; Region: Cytochrom_C; pfam00034 634500001928 Cytochrome c; Region: Cytochrom_C; pfam00034 634500001929 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500001930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500001931 dimerization interface [polypeptide binding]; other site 634500001932 putative DNA binding site [nucleotide binding]; other site 634500001933 putative Zn2+ binding site [ion binding]; other site 634500001934 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 634500001935 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 634500001936 NADP binding site [chemical binding]; other site 634500001937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500001938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500001939 putative substrate translocation pore; other site 634500001940 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634500001941 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 634500001942 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500001943 Uncharacterized conserved protein [Function unknown]; Region: COG2353 634500001944 D-lactate dehydrogenase; Provisional; Region: PRK11183 634500001945 FAD binding domain; Region: FAD_binding_4; pfam01565 634500001946 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 634500001947 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 634500001948 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500001949 Catalytic site [active] 634500001950 Protein of unknown function (DUF770); Region: DUF770; pfam05591 634500001951 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 634500001952 Protein of unknown function (DUF877); Region: DUF877; pfam05943 634500001953 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 634500001954 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 634500001955 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 634500001956 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 634500001957 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500001958 ligand binding site [chemical binding]; other site 634500001959 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 634500001960 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 634500001961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500001962 Walker A motif; other site 634500001963 ATP binding site [chemical binding]; other site 634500001964 Walker B motif; other site 634500001965 arginine finger; other site 634500001966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500001967 Walker A motif; other site 634500001968 ATP binding site [chemical binding]; other site 634500001969 Walker B motif; other site 634500001970 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 634500001971 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 634500001972 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 634500001973 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 634500001974 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 634500001975 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 634500001976 PGAP1-like protein; Region: PGAP1; pfam07819 634500001977 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 634500001978 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 634500001979 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 634500001980 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 634500001981 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 634500001982 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 634500001983 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 634500001984 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 634500001985 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 634500001986 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 634500001987 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 634500001988 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 634500001989 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 634500001990 ImpA domain protein; Region: DUF3702; pfam12486 634500001991 putative transcriptional regulator; Provisional; Region: PRK11640 634500001992 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 634500001993 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 634500001994 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 634500001995 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 634500001996 DsbD alpha interface [polypeptide binding]; other site 634500001997 catalytic residues [active] 634500001998 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 634500001999 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 634500002000 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 634500002001 Aspartase; Region: Aspartase; cd01357 634500002002 active sites [active] 634500002003 tetramer interface [polypeptide binding]; other site 634500002004 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 634500002005 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 634500002006 oligomerisation interface [polypeptide binding]; other site 634500002007 mobile loop; other site 634500002008 roof hairpin; other site 634500002009 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 634500002010 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 634500002011 ring oligomerisation interface [polypeptide binding]; other site 634500002012 ATP/Mg binding site [chemical binding]; other site 634500002013 stacking interactions; other site 634500002014 hinge regions; other site 634500002015 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 634500002016 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 634500002017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500002018 FeS/SAM binding site; other site 634500002019 elongation factor P; Validated; Region: PRK00529 634500002020 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 634500002021 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 634500002022 RNA binding site [nucleotide binding]; other site 634500002023 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 634500002024 RNA binding site [nucleotide binding]; other site 634500002025 entericidin A; Provisional; Region: PRK09810 634500002026 Entericidin EcnA/B family; Region: Entericidin; cl02322 634500002027 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 634500002028 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 634500002029 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 634500002030 Iron-sulfur protein interface; other site 634500002031 proximal quinone binding site [chemical binding]; other site 634500002032 C-subunit interface; other site 634500002033 distal quinone binding site; other site 634500002034 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 634500002035 D-subunit interface [polypeptide binding]; other site 634500002036 Iron-sulfur protein interface; other site 634500002037 proximal quinone binding site [chemical binding]; other site 634500002038 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 634500002039 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 634500002040 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 634500002041 L-aspartate oxidase; Provisional; Region: PRK06175 634500002042 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 634500002043 poxB regulator PoxA; Provisional; Region: PRK09350 634500002044 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 634500002045 motif 1; other site 634500002046 dimer interface [polypeptide binding]; other site 634500002047 active site 634500002048 motif 2; other site 634500002049 motif 3; other site 634500002050 putative mechanosensitive channel protein; Provisional; Region: PRK10929 634500002051 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 634500002052 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500002053 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 634500002054 GTPase RsgA; Reviewed; Region: PRK12288 634500002055 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 634500002056 RNA binding site [nucleotide binding]; other site 634500002057 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 634500002058 GTPase/Zn-binding domain interface [polypeptide binding]; other site 634500002059 GTP/Mg2+ binding site [chemical binding]; other site 634500002060 G4 box; other site 634500002061 G5 box; other site 634500002062 G1 box; other site 634500002063 Switch I region; other site 634500002064 G2 box; other site 634500002065 G3 box; other site 634500002066 Switch II region; other site 634500002067 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 634500002068 catalytic site [active] 634500002069 putative active site [active] 634500002070 putative substrate binding site [chemical binding]; other site 634500002071 dimer interface [polypeptide binding]; other site 634500002072 epoxyqueuosine reductase; Region: TIGR00276 634500002073 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 634500002074 putative carbohydrate kinase; Provisional; Region: PRK10565 634500002075 Uncharacterized conserved protein [Function unknown]; Region: COG0062 634500002076 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 634500002077 putative substrate binding site [chemical binding]; other site 634500002078 putative ATP binding site [chemical binding]; other site 634500002079 ADP-binding protein; Provisional; Region: PRK10646 634500002080 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 634500002081 AMIN domain; Region: AMIN; pfam11741 634500002082 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634500002083 active site 634500002084 metal binding site [ion binding]; metal-binding site 634500002085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500002086 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 634500002087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500002088 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 634500002089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500002090 ATP binding site [chemical binding]; other site 634500002091 Mg2+ binding site [ion binding]; other site 634500002092 G-X-G motif; other site 634500002093 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 634500002094 ATP binding site [chemical binding]; other site 634500002095 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 634500002096 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 634500002097 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 634500002098 bacterial Hfq-like; Region: Hfq; cd01716 634500002099 hexamer interface [polypeptide binding]; other site 634500002100 Sm1 motif; other site 634500002101 RNA binding site [nucleotide binding]; other site 634500002102 Sm2 motif; other site 634500002103 GTPase HflX; Provisional; Region: PRK11058 634500002104 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 634500002105 HflX GTPase family; Region: HflX; cd01878 634500002106 G1 box; other site 634500002107 GTP/Mg2+ binding site [chemical binding]; other site 634500002108 Switch I region; other site 634500002109 G2 box; other site 634500002110 G3 box; other site 634500002111 Switch II region; other site 634500002112 G4 box; other site 634500002113 G5 box; other site 634500002114 FtsH protease regulator HflK; Provisional; Region: PRK10930 634500002115 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 634500002116 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 634500002117 FtsH protease regulator HflC; Provisional; Region: PRK11029 634500002118 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 634500002119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 634500002120 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 634500002121 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 634500002122 GDP-binding site [chemical binding]; other site 634500002123 ACT binding site; other site 634500002124 IMP binding site; other site 634500002125 Predicted transcriptional regulator [Transcription]; Region: COG1959 634500002126 transcriptional repressor NsrR; Provisional; Region: PRK11014 634500002127 exoribonuclease R; Provisional; Region: PRK11642 634500002128 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 634500002129 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 634500002130 RNB domain; Region: RNB; pfam00773 634500002131 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 634500002132 RNA binding site [nucleotide binding]; other site 634500002133 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 634500002134 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 634500002135 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634500002136 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 634500002137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634500002138 active site 634500002139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500002140 dimerization interface [polypeptide binding]; other site 634500002141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500002142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500002143 dimer interface [polypeptide binding]; other site 634500002144 putative CheW interface [polypeptide binding]; other site 634500002145 esterase; Provisional; Region: PRK10566 634500002146 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500002147 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 634500002148 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 634500002149 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 634500002150 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 634500002151 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 634500002152 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 634500002153 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 634500002154 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 634500002155 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 634500002156 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634500002157 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 634500002158 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 634500002159 active site 634500002160 metal binding site [ion binding]; metal-binding site 634500002161 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 634500002162 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 634500002163 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 634500002164 active site 634500002165 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 634500002166 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 634500002167 Domain of unknown function DUF21; Region: DUF21; pfam01595 634500002168 hypothetical protein; Provisional; Region: PRK11573 634500002169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634500002170 Transporter associated domain; Region: CorC_HlyC; smart01091 634500002171 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 634500002172 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500002173 Surface antigen; Region: Bac_surface_Ag; pfam01103 634500002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 634500002175 Family of unknown function (DUF490); Region: DUF490; pfam04357 634500002176 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 634500002177 putative active site pocket [active] 634500002178 dimerization interface [polypeptide binding]; other site 634500002179 putative catalytic residue [active] 634500002180 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 634500002181 dimer interface [polypeptide binding]; other site 634500002182 substrate binding site [chemical binding]; other site 634500002183 metal binding sites [ion binding]; metal-binding site 634500002184 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 634500002185 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500002186 dimer interface [polypeptide binding]; other site 634500002187 ligand binding site [chemical binding]; other site 634500002188 HAMP domain; Region: HAMP; pfam00672 634500002189 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500002190 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500002191 dimer interface [polypeptide binding]; other site 634500002192 putative CheW interface [polypeptide binding]; other site 634500002193 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 634500002194 AMP binding site [chemical binding]; other site 634500002195 metal binding site [ion binding]; metal-binding site 634500002196 active site 634500002197 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 634500002198 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634500002199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500002200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500002201 hypothetical protein; Provisional; Region: PRK05255 634500002202 peptidase PmbA; Provisional; Region: PRK11040 634500002203 Cytochrome b562; Region: Cytochrom_B562; cl01546 634500002204 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 634500002205 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 634500002206 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 634500002207 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 634500002208 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 634500002209 dihydroorotase; Provisional; Region: PRK09237 634500002210 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500002211 active site 634500002212 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 634500002213 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 634500002214 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 634500002215 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 634500002216 HTH domain; Region: HTH_11; pfam08279 634500002217 Mga helix-turn-helix domain; Region: Mga; pfam05043 634500002218 PRD domain; Region: PRD; pfam00874 634500002219 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 634500002220 active site 634500002221 P-loop; other site 634500002222 phosphorylation site [posttranslational modification] 634500002223 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500002224 active site 634500002225 phosphorylation site [posttranslational modification] 634500002226 outer membrane lipoprotein; Provisional; Region: PRK11023 634500002227 BON domain; Region: BON; pfam04972 634500002228 BON domain; Region: BON; pfam04972 634500002229 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 634500002230 dimer interface [polypeptide binding]; other site 634500002231 active site 634500002232 hypothetical protein; Reviewed; Region: PRK12497 634500002233 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500002234 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 634500002235 putative ligand binding site [chemical binding]; other site 634500002236 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 634500002237 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 634500002238 putative SAM binding site [chemical binding]; other site 634500002239 putative homodimer interface [polypeptide binding]; other site 634500002240 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 634500002241 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 634500002242 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 634500002243 shikimate binding site; other site 634500002244 NAD(P) binding site [chemical binding]; other site 634500002245 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 634500002246 Pirin-related protein [General function prediction only]; Region: COG1741 634500002247 Pirin; Region: Pirin; pfam02678 634500002248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002249 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 634500002250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500002251 dimerization interface [polypeptide binding]; other site 634500002252 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 634500002253 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 634500002254 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 634500002255 putative dimer interface [polypeptide binding]; other site 634500002256 N-terminal domain interface [polypeptide binding]; other site 634500002257 putative substrate binding pocket (H-site) [chemical binding]; other site 634500002258 Predicted membrane protein [Function unknown]; Region: COG2259 634500002259 YqjK-like protein; Region: YqjK; pfam13997 634500002260 Predicted membrane protein [Function unknown]; Region: COG5393 634500002261 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 634500002262 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 634500002263 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 634500002264 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 634500002265 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634500002266 altronate oxidoreductase; Provisional; Region: PRK03643 634500002267 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 634500002268 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 634500002269 galactarate dehydratase; Region: galactar-dH20; TIGR03248 634500002270 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 634500002271 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 634500002272 serine/threonine transporter SstT; Provisional; Region: PRK13628 634500002273 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634500002274 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 634500002275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500002276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500002277 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 634500002278 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 634500002279 Cl- selectivity filter; other site 634500002280 Cl- binding residues [ion binding]; other site 634500002281 pore gating glutamate residue; other site 634500002282 dimer interface [polypeptide binding]; other site 634500002283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 634500002284 BtpA family; Region: BtpA; cl00440 634500002285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500002286 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 634500002287 substrate binding site [chemical binding]; other site 634500002288 ATP binding site [chemical binding]; other site 634500002289 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 634500002290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500002291 DNA-binding site [nucleotide binding]; DNA binding site 634500002292 UTRA domain; Region: UTRA; pfam07702 634500002293 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500002294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500002295 DNA-binding site [nucleotide binding]; DNA binding site 634500002296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500002298 homodimer interface [polypeptide binding]; other site 634500002299 catalytic residue [active] 634500002300 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634500002301 EamA-like transporter family; Region: EamA; pfam00892 634500002302 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 634500002303 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 634500002304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500002305 S-adenosylmethionine binding site [chemical binding]; other site 634500002306 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 634500002307 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 634500002308 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 634500002309 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500002310 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 634500002311 active site 634500002312 FMN binding site [chemical binding]; other site 634500002313 2,4-decadienoyl-CoA binding site; other site 634500002314 catalytic residue [active] 634500002315 4Fe-4S cluster binding site [ion binding]; other site 634500002316 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 634500002317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500002318 fructuronate transporter; Provisional; Region: PRK10034; cl15264 634500002319 gluconate transporter; Region: gntP; TIGR00791 634500002320 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500002321 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634500002322 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500002323 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500002324 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 634500002325 Domain of unknown function (DUF336); Region: DUF336; pfam03928 634500002326 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634500002327 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 634500002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 634500002329 hypothetical protein; Provisional; Region: PRK09262 634500002330 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 634500002331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500002332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002333 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 634500002334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002335 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 634500002336 putative dimerization interface [polypeptide binding]; other site 634500002337 Dehydroquinase class II; Region: DHquinase_II; pfam01220 634500002338 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 634500002339 trimer interface [polypeptide binding]; other site 634500002340 active site 634500002341 dimer interface [polypeptide binding]; other site 634500002342 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 634500002343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500002344 active site 634500002345 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 634500002346 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 634500002347 putative active site [active] 634500002348 Fe(II) binding site [ion binding]; other site 634500002349 putative dimer interface [polypeptide binding]; other site 634500002350 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 634500002351 putative dimer interface [polypeptide binding]; other site 634500002352 putative N- and C-terminal domain interface [polypeptide binding]; other site 634500002353 benzoate transport; Region: 2A0115; TIGR00895 634500002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002355 putative substrate translocation pore; other site 634500002356 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 634500002357 active site clefts [active] 634500002358 zinc binding site [ion binding]; other site 634500002359 dimer interface [polypeptide binding]; other site 634500002360 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 634500002361 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 634500002362 Sulfate transporter family; Region: Sulfate_transp; pfam00916 634500002363 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 634500002364 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634500002365 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634500002366 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 634500002367 Walker A/P-loop; other site 634500002368 ATP binding site [chemical binding]; other site 634500002369 Q-loop/lid; other site 634500002370 ABC transporter signature motif; other site 634500002371 Walker B; other site 634500002372 D-loop; other site 634500002373 H-loop/switch region; other site 634500002374 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634500002375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500002376 dimer interface [polypeptide binding]; other site 634500002377 conserved gate region; other site 634500002378 putative PBP binding loops; other site 634500002379 ABC-ATPase subunit interface; other site 634500002380 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634500002381 NMT1-like family; Region: NMT1_2; pfam13379 634500002382 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 634500002383 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 634500002384 TrkA-C domain; Region: TrkA_C; pfam02080 634500002385 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 634500002386 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 634500002387 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 634500002388 TrkA-C domain; Region: TrkA_C; pfam02080 634500002389 TrkA-C domain; Region: TrkA_C; pfam02080 634500002390 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 634500002391 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 634500002392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500002393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500002394 homodimer interface [polypeptide binding]; other site 634500002395 catalytic residue [active] 634500002396 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 634500002397 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 634500002398 Protein of unknown function DUF262; Region: DUF262; pfam03235 634500002399 Uncharacterized conserved protein [Function unknown]; Region: COG1479 634500002400 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 634500002401 classical (c) SDRs; Region: SDR_c; cd05233 634500002402 NAD(P) binding site [chemical binding]; other site 634500002403 active site 634500002404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500002405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500002406 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 634500002407 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500002408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500002409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500002410 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 634500002411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500002412 NAD(P) binding site [chemical binding]; other site 634500002413 active site 634500002414 short chain dehydrogenase; Provisional; Region: PRK06482 634500002415 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 634500002416 NADP binding site [chemical binding]; other site 634500002417 active site 634500002418 steroid binding site; other site 634500002419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500002420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002421 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500002422 putative effector binding pocket; other site 634500002423 putative dimerization interface [polypeptide binding]; other site 634500002424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500002425 catalytic core [active] 634500002426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002427 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500002428 putative substrate translocation pore; other site 634500002429 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500002430 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500002431 DNA binding site [nucleotide binding] 634500002432 domain linker motif; other site 634500002433 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634500002434 dimerization interface [polypeptide binding]; other site 634500002435 ligand binding site [chemical binding]; other site 634500002436 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 634500002437 active site 634500002438 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 634500002439 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 634500002440 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 634500002441 putative sialic acid transporter; Region: 2A0112; TIGR00891 634500002442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002443 putative substrate translocation pore; other site 634500002444 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 634500002445 putative deacylase active site [active] 634500002446 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 634500002447 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 634500002448 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 634500002449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500002450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500002451 metal binding site [ion binding]; metal-binding site 634500002452 active site 634500002453 I-site; other site 634500002454 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 634500002455 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 634500002456 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 634500002457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500002458 S-adenosylmethionine binding site [chemical binding]; other site 634500002459 DNA polymerase III subunit psi; Validated; Region: PRK06856 634500002460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500002461 Coenzyme A binding pocket [chemical binding]; other site 634500002462 dUMP phosphatase; Provisional; Region: PRK09449 634500002463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500002464 motif II; other site 634500002465 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 634500002466 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 634500002467 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 634500002468 hypothetical protein; Provisional; Region: PRK07033 634500002469 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 634500002470 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500002471 ligand binding site [chemical binding]; other site 634500002472 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 634500002473 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 634500002474 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 634500002475 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 634500002476 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 634500002477 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 634500002478 Protein of unknown function (DUF770); Region: DUF770; pfam05591 634500002479 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 634500002480 Protein of unknown function (DUF877); Region: DUF877; pfam05943 634500002481 Protein of unknown function (DUF796); Region: DUF796; pfam05638 634500002482 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 634500002483 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 634500002484 phosphopeptide binding site; other site 634500002485 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 634500002486 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 634500002487 active site 634500002488 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 634500002489 ImpE protein; Region: ImpE; pfam07024 634500002490 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 634500002491 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 634500002492 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 634500002493 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 634500002494 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 634500002495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500002496 Walker A motif; other site 634500002497 ATP binding site [chemical binding]; other site 634500002498 Walker B motif; other site 634500002499 arginine finger; other site 634500002500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500002501 Walker A motif; other site 634500002502 ATP binding site [chemical binding]; other site 634500002503 Walker B motif; other site 634500002504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634500002505 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 634500002506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 634500002507 active site 634500002508 ATP binding site [chemical binding]; other site 634500002509 substrate binding site [chemical binding]; other site 634500002510 activation loop (A-loop); other site 634500002511 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 634500002512 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 634500002513 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 634500002514 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 634500002515 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 634500002516 PAAR motif; Region: PAAR_motif; pfam05488 634500002517 RHS Repeat; Region: RHS_repeat; cl11982 634500002518 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 634500002519 RHS Repeat; Region: RHS_repeat; pfam05593 634500002520 RHS protein; Region: RHS; pfam03527 634500002521 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 634500002522 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 634500002523 putative S-transferase; Provisional; Region: PRK11752 634500002524 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 634500002525 C-terminal domain interface [polypeptide binding]; other site 634500002526 GSH binding site (G-site) [chemical binding]; other site 634500002527 dimer interface [polypeptide binding]; other site 634500002528 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 634500002529 dimer interface [polypeptide binding]; other site 634500002530 N-terminal domain interface [polypeptide binding]; other site 634500002531 active site 634500002532 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 634500002533 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 634500002534 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 634500002535 G1 box; other site 634500002536 putative GEF interaction site [polypeptide binding]; other site 634500002537 GTP/Mg2+ binding site [chemical binding]; other site 634500002538 Switch I region; other site 634500002539 G2 box; other site 634500002540 G3 box; other site 634500002541 Switch II region; other site 634500002542 G4 box; other site 634500002543 G5 box; other site 634500002544 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 634500002545 periplasmic protein; Provisional; Region: PRK10568 634500002546 BON domain; Region: BON; cl02771 634500002547 BON domain; Region: BON; pfam04972 634500002548 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 634500002549 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 634500002550 active site 634500002551 nucleophile elbow; other site 634500002552 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 634500002553 active site 634500002554 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 634500002555 intersubunit interface [polypeptide binding]; other site 634500002556 active site 634500002557 catalytic residue [active] 634500002558 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 634500002559 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 634500002560 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 634500002561 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 634500002562 phosphopentomutase; Provisional; Region: PRK05362 634500002563 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 634500002564 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 634500002565 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 634500002566 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 634500002567 HipA-like N-terminal domain; Region: HipA_N; pfam07805 634500002568 HipA-like C-terminal domain; Region: HipA_C; pfam07804 634500002569 hypothetical protein; Provisional; Region: PRK11246 634500002570 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 634500002571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500002572 motif II; other site 634500002573 DNA repair protein RadA; Region: sms; TIGR00416 634500002574 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 634500002575 Walker A motif/ATP binding site; other site 634500002576 ATP binding site [chemical binding]; other site 634500002577 Walker B motif; other site 634500002578 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 634500002579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500002580 non-specific DNA binding site [nucleotide binding]; other site 634500002581 salt bridge; other site 634500002582 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 634500002583 sequence-specific DNA binding site [nucleotide binding]; other site 634500002584 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 634500002585 active site 634500002586 (T/H)XGH motif; other site 634500002587 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 634500002588 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 634500002589 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 634500002590 putative NAD(P) binding site [chemical binding]; other site 634500002591 dimer interface [polypeptide binding]; other site 634500002592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500002593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500002595 putative effector binding pocket; other site 634500002596 dimerization interface [polypeptide binding]; other site 634500002597 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 634500002598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500002599 Walker A/P-loop; other site 634500002600 ATP binding site [chemical binding]; other site 634500002601 Q-loop/lid; other site 634500002602 ABC transporter signature motif; other site 634500002603 Walker B; other site 634500002604 D-loop; other site 634500002605 H-loop/switch region; other site 634500002606 ABC transporter; Region: ABC_tran_2; pfam12848 634500002607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500002608 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 634500002609 glycerate dehydrogenase; Provisional; Region: PRK06932 634500002610 putative ligand binding site [chemical binding]; other site 634500002611 putative NAD binding site [chemical binding]; other site 634500002612 catalytic site [active] 634500002613 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 634500002614 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 634500002615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500002616 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 634500002617 intersubunit interface [polypeptide binding]; other site 634500002618 active site 634500002619 catalytic residue [active] 634500002620 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500002621 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 634500002622 substrate binding site [chemical binding]; other site 634500002623 dimer interface [polypeptide binding]; other site 634500002624 ATP binding site [chemical binding]; other site 634500002625 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 634500002626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002627 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 634500002628 active site 634500002629 catalytic residues [active] 634500002630 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 634500002631 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 634500002632 substrate binding site [chemical binding]; other site 634500002633 ligand binding site [chemical binding]; other site 634500002634 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 634500002635 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 634500002636 substrate binding site [chemical binding]; other site 634500002637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 634500002638 transcriptional activator TtdR; Provisional; Region: PRK09801 634500002639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 634500002641 putative effector binding pocket; other site 634500002642 putative dimerization interface [polypeptide binding]; other site 634500002643 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500002644 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 634500002645 putative ligand binding site [chemical binding]; other site 634500002646 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 634500002647 Condensation domain; Region: Condensation; pfam00668 634500002648 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 634500002649 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 634500002650 acyl-activating enzyme (AAE) consensus motif; other site 634500002651 AMP binding site [chemical binding]; other site 634500002652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 634500002653 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 634500002654 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 634500002655 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634500002656 Walker A/P-loop; other site 634500002657 ATP binding site [chemical binding]; other site 634500002658 Q-loop/lid; other site 634500002659 ABC transporter signature motif; other site 634500002660 Walker B; other site 634500002661 D-loop; other site 634500002662 H-loop/switch region; other site 634500002663 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 634500002664 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634500002665 Walker A/P-loop; other site 634500002666 ATP binding site [chemical binding]; other site 634500002667 Q-loop/lid; other site 634500002668 ABC transporter signature motif; other site 634500002669 Walker B; other site 634500002670 D-loop; other site 634500002671 H-loop/switch region; other site 634500002672 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 634500002673 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634500002674 TM-ABC transporter signature motif; other site 634500002675 HEAT repeats; Region: HEAT_2; pfam13646 634500002676 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634500002677 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500002678 TM-ABC transporter signature motif; other site 634500002679 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 634500002680 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 634500002681 putative ligand binding site [chemical binding]; other site 634500002682 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500002683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500002684 DNA-binding site [nucleotide binding]; DNA binding site 634500002685 FCD domain; Region: FCD; pfam07729 634500002686 urea carboxylase; Region: urea_carbox; TIGR02712 634500002687 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634500002688 ATP-grasp domain; Region: ATP-grasp_4; cl17255 634500002689 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 634500002690 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 634500002691 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 634500002692 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634500002693 carboxyltransferase (CT) interaction site; other site 634500002694 biotinylation site [posttranslational modification]; other site 634500002695 allophanate hydrolase; Provisional; Region: PRK08186 634500002696 Amidase; Region: Amidase; cl11426 634500002697 LysR family transcriptional regulator; Provisional; Region: PRK14997 634500002698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002699 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500002700 putative effector binding pocket; other site 634500002701 dimerization interface [polypeptide binding]; other site 634500002702 Pirin-related protein [General function prediction only]; Region: COG1741 634500002703 Pirin; Region: Pirin; pfam02678 634500002704 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 634500002705 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500002706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500002707 Transmembrane secretion effector; Region: MFS_3; pfam05977 634500002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002709 putative substrate translocation pore; other site 634500002710 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 634500002711 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 634500002712 active site 634500002713 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 634500002714 Isochorismatase family; Region: Isochorismatase; pfam00857 634500002715 catalytic triad [active] 634500002716 dimer interface [polypeptide binding]; other site 634500002717 conserved cis-peptide bond; other site 634500002718 Response regulator receiver domain; Region: Response_reg; pfam00072 634500002719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500002720 active site 634500002721 phosphorylation site [posttranslational modification] 634500002722 intermolecular recognition site; other site 634500002723 dimerization interface [polypeptide binding]; other site 634500002724 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 634500002725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 634500002726 active site 634500002727 ATP binding site [chemical binding]; other site 634500002728 substrate binding site [chemical binding]; other site 634500002729 activation loop (A-loop); other site 634500002730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 634500002731 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 634500002732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500002733 PAS fold; Region: PAS_3; pfam08447 634500002734 putative active site [active] 634500002735 heme pocket [chemical binding]; other site 634500002736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500002737 dimer interface [polypeptide binding]; other site 634500002738 phosphorylation site [posttranslational modification] 634500002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500002740 ATP binding site [chemical binding]; other site 634500002741 G-X-G motif; other site 634500002742 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 634500002743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500002744 active site 634500002745 phosphorylation site [posttranslational modification] 634500002746 intermolecular recognition site; other site 634500002747 dimerization interface [polypeptide binding]; other site 634500002748 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500002749 DNA binding residues [nucleotide binding] 634500002750 dimerization interface [polypeptide binding]; other site 634500002751 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 634500002752 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500002753 active site turn [active] 634500002754 phosphorylation site [posttranslational modification] 634500002755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500002756 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 634500002757 HPr interaction site; other site 634500002758 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634500002759 active site 634500002760 phosphorylation site [posttranslational modification] 634500002761 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 634500002762 beta-galactosidase; Region: BGL; TIGR03356 634500002763 transcriptional antiterminator BglG; Provisional; Region: PRK09772 634500002764 CAT RNA binding domain; Region: CAT_RBD; pfam03123 634500002765 PRD domain; Region: PRD; pfam00874 634500002766 PRD domain; Region: PRD; pfam00874 634500002767 lytic murein transglycosylase; Provisional; Region: PRK11619 634500002768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500002769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500002770 catalytic residue [active] 634500002771 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 634500002772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500002773 catalytic core [active] 634500002774 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 634500002775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500002776 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 634500002777 hypothetical protein; Provisional; Region: PRK10756 634500002778 CreA protein; Region: CreA; pfam05981 634500002779 two-component response regulator; Provisional; Region: PRK11173 634500002780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500002781 active site 634500002782 phosphorylation site [posttranslational modification] 634500002783 intermolecular recognition site; other site 634500002784 dimerization interface [polypeptide binding]; other site 634500002785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500002786 DNA binding site [nucleotide binding] 634500002787 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 634500002788 putative RNA methyltransferase; Provisional; Region: PRK10433 634500002789 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 634500002790 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 634500002791 putative catalytic residues [active] 634500002792 putative nucleotide binding site [chemical binding]; other site 634500002793 putative aspartate binding site [chemical binding]; other site 634500002794 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 634500002795 dimer interface [polypeptide binding]; other site 634500002796 putative threonine allosteric regulatory site; other site 634500002797 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 634500002798 putative threonine allosteric regulatory site; other site 634500002799 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 634500002800 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 634500002801 homoserine kinase; Provisional; Region: PRK01212 634500002802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634500002803 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 634500002804 threonine synthase; Validated; Region: PRK09225 634500002805 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 634500002806 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500002807 catalytic residue [active] 634500002808 hypothetical protein; Validated; Region: PRK02101 634500002809 transaldolase-like protein; Provisional; Region: PTZ00411 634500002810 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 634500002811 active site 634500002812 dimer interface [polypeptide binding]; other site 634500002813 catalytic residue [active] 634500002814 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 634500002815 MPT binding site; other site 634500002816 trimer interface [polypeptide binding]; other site 634500002817 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500002818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002819 putative substrate translocation pore; other site 634500002820 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 634500002821 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 634500002822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 634500002823 nucleotide binding site [chemical binding]; other site 634500002824 chaperone protein DnaJ; Provisional; Region: PRK10767 634500002825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 634500002826 HSP70 interaction site [polypeptide binding]; other site 634500002827 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 634500002828 substrate binding site [polypeptide binding]; other site 634500002829 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 634500002830 Zn binding sites [ion binding]; other site 634500002831 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 634500002832 dimer interface [polypeptide binding]; other site 634500002833 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 634500002834 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 634500002835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500002836 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 634500002837 putative dimerization interface [polypeptide binding]; other site 634500002838 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 634500002839 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 634500002840 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 634500002841 active site 634500002842 Riboflavin kinase; Region: Flavokinase; smart00904 634500002843 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 634500002844 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 634500002845 active site 634500002846 HIGH motif; other site 634500002847 nucleotide binding site [chemical binding]; other site 634500002848 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 634500002849 active site 634500002850 KMSKS motif; other site 634500002851 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 634500002852 tRNA binding surface [nucleotide binding]; other site 634500002853 anticodon binding site; other site 634500002854 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 634500002855 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 634500002856 lipoprotein signal peptidase; Provisional; Region: PRK14787 634500002857 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 634500002858 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634500002859 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 634500002860 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 634500002861 dihydrodipicolinate reductase; Provisional; Region: PRK00048 634500002862 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 634500002863 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 634500002864 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 634500002865 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 634500002866 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 634500002867 catalytic site [active] 634500002868 subunit interface [polypeptide binding]; other site 634500002869 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 634500002870 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634500002871 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634500002872 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 634500002873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634500002874 ATP-grasp domain; Region: ATP-grasp_4; cl17255 634500002875 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 634500002876 IMP binding site; other site 634500002877 dimer interface [polypeptide binding]; other site 634500002878 interdomain contacts; other site 634500002879 partial ornithine binding site; other site 634500002880 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500002881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500002882 DNA-binding site [nucleotide binding]; DNA binding site 634500002883 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500002884 hypothetical protein; Provisional; Region: PRK05968 634500002885 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634500002886 homodimer interface [polypeptide binding]; other site 634500002887 substrate-cofactor binding pocket; other site 634500002888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500002889 catalytic residue [active] 634500002890 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634500002891 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634500002892 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500002893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500002894 dimer interface [polypeptide binding]; other site 634500002895 conserved gate region; other site 634500002896 putative PBP binding loops; other site 634500002897 ABC-ATPase subunit interface; other site 634500002898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500002899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500002900 dimer interface [polypeptide binding]; other site 634500002901 conserved gate region; other site 634500002902 putative PBP binding loops; other site 634500002903 ABC-ATPase subunit interface; other site 634500002904 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 634500002905 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634500002906 Walker A/P-loop; other site 634500002907 ATP binding site [chemical binding]; other site 634500002908 Q-loop/lid; other site 634500002909 ABC transporter signature motif; other site 634500002910 Walker B; other site 634500002911 D-loop; other site 634500002912 H-loop/switch region; other site 634500002913 LysE type translocator; Region: LysE; cl00565 634500002914 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 634500002915 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 634500002916 folate binding site [chemical binding]; other site 634500002917 NADP+ binding site [chemical binding]; other site 634500002918 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 634500002919 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 634500002920 active site 634500002921 metal binding site [ion binding]; metal-binding site 634500002922 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 634500002923 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 634500002924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500002925 S-adenosylmethionine binding site [chemical binding]; other site 634500002926 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 634500002927 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 634500002928 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 634500002929 SurA N-terminal domain; Region: SurA_N; pfam09312 634500002930 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 634500002931 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 634500002932 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 634500002933 OstA-like protein; Region: OstA; pfam03968 634500002934 Organic solvent tolerance protein; Region: OstA_C; pfam04453 634500002935 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 634500002936 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 634500002937 putative metal binding site [ion binding]; other site 634500002938 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 634500002939 HSP70 interaction site [polypeptide binding]; other site 634500002940 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 634500002941 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634500002942 active site 634500002943 ATP-dependent helicase HepA; Validated; Region: PRK04914 634500002944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500002945 ATP binding site [chemical binding]; other site 634500002946 putative Mg++ binding site [ion binding]; other site 634500002947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500002948 nucleotide binding region [chemical binding]; other site 634500002949 ATP-binding site [chemical binding]; other site 634500002950 DNA polymerase II; Reviewed; Region: PRK05762 634500002951 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 634500002952 active site 634500002953 catalytic site [active] 634500002954 substrate binding site [chemical binding]; other site 634500002955 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 634500002956 active site 634500002957 metal-binding site 634500002958 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634500002959 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634500002960 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 634500002961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500002962 dimer interface [polypeptide binding]; other site 634500002963 conserved gate region; other site 634500002964 putative PBP binding loops; other site 634500002965 ABC-ATPase subunit interface; other site 634500002966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500002967 dimer interface [polypeptide binding]; other site 634500002968 conserved gate region; other site 634500002969 putative PBP binding loops; other site 634500002970 ABC-ATPase subunit interface; other site 634500002971 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 634500002972 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 634500002973 transcriptional regulator SgrR; Provisional; Region: PRK13626 634500002974 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 634500002975 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 634500002976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500002977 sugar efflux transporter; Region: 2A0120; TIGR00899 634500002978 putative substrate translocation pore; other site 634500002979 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 634500002980 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 634500002981 substrate binding site [chemical binding]; other site 634500002982 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 634500002983 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 634500002984 substrate binding site [chemical binding]; other site 634500002985 ligand binding site [chemical binding]; other site 634500002986 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 634500002987 tartrate dehydrogenase; Provisional; Region: PRK08194 634500002988 2-isopropylmalate synthase; Validated; Region: PRK00915 634500002989 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 634500002990 active site 634500002991 catalytic residues [active] 634500002992 metal binding site [ion binding]; metal-binding site 634500002993 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 634500002994 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 634500002995 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634500002996 PYR/PP interface [polypeptide binding]; other site 634500002997 dimer interface [polypeptide binding]; other site 634500002998 TPP binding site [chemical binding]; other site 634500002999 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500003000 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 634500003001 TPP-binding site [chemical binding]; other site 634500003002 dimer interface [polypeptide binding]; other site 634500003003 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 634500003004 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 634500003005 putative valine binding site [chemical binding]; other site 634500003006 dimer interface [polypeptide binding]; other site 634500003007 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 634500003008 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 634500003009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500003010 DNA binding site [nucleotide binding] 634500003011 domain linker motif; other site 634500003012 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 634500003013 dimerization interface [polypeptide binding]; other site 634500003014 ligand binding site [chemical binding]; other site 634500003015 cell division protein MraZ; Reviewed; Region: PRK00326 634500003016 MraZ protein; Region: MraZ; pfam02381 634500003017 MraZ protein; Region: MraZ; pfam02381 634500003018 MraW methylase family; Region: Methyltransf_5; pfam01795 634500003019 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 634500003020 cell division protein FtsL; Provisional; Region: PRK10772 634500003021 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 634500003022 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634500003023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634500003024 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 634500003025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634500003026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500003027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500003028 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 634500003029 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634500003030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500003031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500003032 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 634500003033 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 634500003034 Mg++ binding site [ion binding]; other site 634500003035 putative catalytic motif [active] 634500003036 putative substrate binding site [chemical binding]; other site 634500003037 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 634500003038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500003039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500003040 cell division protein FtsW; Provisional; Region: PRK10774 634500003041 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 634500003042 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 634500003043 active site 634500003044 homodimer interface [polypeptide binding]; other site 634500003045 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 634500003046 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 634500003047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500003048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500003049 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 634500003050 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 634500003051 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 634500003052 cell division protein FtsQ; Provisional; Region: PRK10775 634500003053 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 634500003054 Cell division protein FtsQ; Region: FtsQ; pfam03799 634500003055 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 634500003056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500003057 Cell division protein FtsA; Region: FtsA; pfam14450 634500003058 cell division protein FtsZ; Validated; Region: PRK09330 634500003059 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 634500003060 nucleotide binding site [chemical binding]; other site 634500003061 SulA interaction site; other site 634500003062 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 634500003063 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 634500003064 Protein of unknown function (DUF721); Region: DUF721; cl02324 634500003065 SecA regulator SecM; Provisional; Region: PRK02943 634500003066 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 634500003067 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 634500003068 SEC-C motif; Region: SEC-C; pfam02810 634500003069 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 634500003070 active site 634500003071 8-oxo-dGMP binding site [chemical binding]; other site 634500003072 nudix motif; other site 634500003073 metal binding site [ion binding]; metal-binding site 634500003074 DNA gyrase inhibitor; Reviewed; Region: PRK00418 634500003075 hypothetical protein; Provisional; Region: PRK05287 634500003076 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 634500003077 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 634500003078 CoA-binding site [chemical binding]; other site 634500003079 ATP-binding [chemical binding]; other site 634500003080 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 634500003081 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 634500003082 active site 634500003083 type IV pilin biogenesis protein; Provisional; Region: PRK10573 634500003084 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634500003085 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 634500003086 hypothetical protein; Provisional; Region: PRK10436 634500003087 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 634500003088 Walker A motif; other site 634500003089 ATP binding site [chemical binding]; other site 634500003090 Walker B motif; other site 634500003091 putative major pilin subunit; Provisional; Region: PRK10574 634500003092 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 634500003093 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 634500003094 dimerization interface [polypeptide binding]; other site 634500003095 active site 634500003096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 634500003097 Anti-sigma-K factor rskA; Region: RskA; pfam10099 634500003098 silverDB:661Eb01011 634500003099 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 634500003100 Fasciclin domain; Region: Fasciclin; pfam02469 634500003101 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 634500003102 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 634500003103 amidase catalytic site [active] 634500003104 Zn binding residues [ion binding]; other site 634500003105 substrate binding site [chemical binding]; other site 634500003106 regulatory protein AmpE; Provisional; Region: PRK10987 634500003107 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 634500003108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003109 putative substrate translocation pore; other site 634500003110 aromatic amino acid transporter; Provisional; Region: PRK10238 634500003111 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 634500003112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500003113 DNA-binding site [nucleotide binding]; DNA binding site 634500003114 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500003115 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 634500003116 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 634500003117 dimer interface [polypeptide binding]; other site 634500003118 TPP-binding site [chemical binding]; other site 634500003119 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 634500003120 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634500003121 E3 interaction surface; other site 634500003122 lipoyl attachment site [posttranslational modification]; other site 634500003123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634500003124 E3 interaction surface; other site 634500003125 lipoyl attachment site [posttranslational modification]; other site 634500003126 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634500003127 E3 interaction surface; other site 634500003128 lipoyl attachment site [posttranslational modification]; other site 634500003129 e3 binding domain; Region: E3_binding; pfam02817 634500003130 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634500003131 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 634500003132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634500003133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500003134 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634500003135 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 634500003136 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 634500003137 substrate binding site [chemical binding]; other site 634500003138 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 634500003139 substrate binding site [chemical binding]; other site 634500003140 ligand binding site [chemical binding]; other site 634500003141 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 634500003142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500003143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500003144 Walker A/P-loop; other site 634500003145 ATP binding site [chemical binding]; other site 634500003146 Q-loop/lid; other site 634500003147 ABC transporter signature motif; other site 634500003148 Walker B; other site 634500003149 D-loop; other site 634500003150 H-loop/switch region; other site 634500003151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500003152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500003153 Walker A/P-loop; other site 634500003154 ATP binding site [chemical binding]; other site 634500003155 Q-loop/lid; other site 634500003156 ABC transporter signature motif; other site 634500003157 Walker B; other site 634500003158 D-loop; other site 634500003159 H-loop/switch region; other site 634500003160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500003161 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 634500003162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003163 dimer interface [polypeptide binding]; other site 634500003164 conserved gate region; other site 634500003165 putative PBP binding loops; other site 634500003166 ABC-ATPase subunit interface; other site 634500003167 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500003168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003169 dimer interface [polypeptide binding]; other site 634500003170 conserved gate region; other site 634500003171 putative PBP binding loops; other site 634500003172 ABC-ATPase subunit interface; other site 634500003173 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 634500003174 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 634500003175 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 634500003176 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500003177 putative metal binding site [ion binding]; other site 634500003178 cell density-dependent motility repressor; Provisional; Region: PRK10082 634500003179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500003180 hypothetical protein; Provisional; Region: PRK05248 634500003181 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 634500003182 Putative cyclase; Region: Cyclase; pfam04199 634500003183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003184 D-galactonate transporter; Region: 2A0114; TIGR00893 634500003185 putative substrate translocation pore; other site 634500003186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003187 D-galactonate transporter; Region: 2A0114; TIGR00893 634500003188 putative substrate translocation pore; other site 634500003189 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634500003190 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 634500003191 putative ligand binding site [chemical binding]; other site 634500003192 putative NAD binding site [chemical binding]; other site 634500003193 catalytic site [active] 634500003194 dihydrodipicolinate synthase; Region: dapA; TIGR00674 634500003195 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 634500003196 inhibitor site; inhibition site 634500003197 active site 634500003198 dimer interface [polypeptide binding]; other site 634500003199 catalytic residue [active] 634500003200 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 634500003201 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 634500003202 putative active site [active] 634500003203 metal binding site [ion binding]; metal-binding site 634500003204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 634500003205 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 634500003206 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 634500003207 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500003208 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 634500003209 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500003210 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 634500003211 spermidine synthase; Provisional; Region: PRK00811 634500003212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500003213 S-adenosylmethionine binding site [chemical binding]; other site 634500003214 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 634500003215 multicopper oxidase; Provisional; Region: PRK10965 634500003216 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 634500003217 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 634500003218 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 634500003219 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 634500003220 Ligand binding site; other site 634500003221 metal-binding site 634500003222 methionine gamma-lyase; Validated; Region: PRK07049 634500003223 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 634500003224 homodimer interface [polypeptide binding]; other site 634500003225 substrate-cofactor binding pocket; other site 634500003226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500003227 catalytic residue [active] 634500003228 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 634500003229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500003230 active site 634500003231 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 634500003232 active site clefts [active] 634500003233 zinc binding site [ion binding]; other site 634500003234 dimer interface [polypeptide binding]; other site 634500003235 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 634500003236 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 634500003237 Walker A/P-loop; other site 634500003238 ATP binding site [chemical binding]; other site 634500003239 Q-loop/lid; other site 634500003240 ABC transporter signature motif; other site 634500003241 Walker B; other site 634500003242 D-loop; other site 634500003243 H-loop/switch region; other site 634500003244 inner membrane transport permease; Provisional; Region: PRK15066 634500003245 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 634500003246 Predicted membrane protein [Function unknown]; Region: COG4763 634500003247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500003248 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 634500003249 tetramerization interface [polypeptide binding]; other site 634500003250 active site 634500003251 Pantoate-beta-alanine ligase; Region: PanC; cd00560 634500003252 pantoate--beta-alanine ligase; Region: panC; TIGR00018 634500003253 active site 634500003254 ATP-binding site [chemical binding]; other site 634500003255 pantoate-binding site; other site 634500003256 HXXH motif; other site 634500003257 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 634500003258 oligomerization interface [polypeptide binding]; other site 634500003259 active site 634500003260 metal binding site [ion binding]; metal-binding site 634500003261 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 634500003262 catalytic center binding site [active] 634500003263 ATP binding site [chemical binding]; other site 634500003264 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 634500003265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 634500003266 active site 634500003267 NTP binding site [chemical binding]; other site 634500003268 metal binding triad [ion binding]; metal-binding site 634500003269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 634500003270 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 634500003271 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 634500003272 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 634500003273 active site 634500003274 HIGH motif; other site 634500003275 nucleotide binding site [chemical binding]; other site 634500003276 active site 634500003277 KMSKS motif; other site 634500003278 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 634500003279 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 634500003280 2'-5' RNA ligase; Provisional; Region: PRK15124 634500003281 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 634500003282 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 634500003283 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 634500003284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500003285 ATP binding site [chemical binding]; other site 634500003286 putative Mg++ binding site [ion binding]; other site 634500003287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500003288 nucleotide binding region [chemical binding]; other site 634500003289 ATP-binding site [chemical binding]; other site 634500003290 Helicase associated domain (HA2); Region: HA2; cl04503 634500003291 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 634500003292 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 634500003293 Transglycosylase; Region: Transgly; pfam00912 634500003294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 634500003295 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 634500003296 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500003297 N-terminal plug; other site 634500003298 ligand-binding site [chemical binding]; other site 634500003299 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 634500003300 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634500003301 Walker A/P-loop; other site 634500003302 ATP binding site [chemical binding]; other site 634500003303 Q-loop/lid; other site 634500003304 ABC transporter signature motif; other site 634500003305 Walker B; other site 634500003306 D-loop; other site 634500003307 H-loop/switch region; other site 634500003308 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 634500003309 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500003310 siderophore binding site; other site 634500003311 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500003312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500003313 ABC-ATPase subunit interface; other site 634500003314 dimer interface [polypeptide binding]; other site 634500003315 putative PBP binding regions; other site 634500003316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500003317 ABC-ATPase subunit interface; other site 634500003318 dimer interface [polypeptide binding]; other site 634500003319 putative PBP binding regions; other site 634500003320 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 634500003321 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500003322 inhibitor-cofactor binding pocket; inhibition site 634500003323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500003324 catalytic residue [active] 634500003325 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 634500003326 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 634500003327 Cl- selectivity filter; other site 634500003328 Cl- binding residues [ion binding]; other site 634500003329 pore gating glutamate residue; other site 634500003330 dimer interface [polypeptide binding]; other site 634500003331 H+/Cl- coupling transport residue; other site 634500003332 silverDB:661Eb01086 634500003333 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 634500003334 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 634500003335 cobalamin binding residues [chemical binding]; other site 634500003336 putative BtuC binding residues; other site 634500003337 dimer interface [polypeptide binding]; other site 634500003338 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 634500003339 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 634500003340 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 634500003341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500003342 Zn2+ binding site [ion binding]; other site 634500003343 Mg2+ binding site [ion binding]; other site 634500003344 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 634500003345 serine endoprotease; Provisional; Region: PRK10942 634500003346 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634500003347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634500003348 protein binding site [polypeptide binding]; other site 634500003349 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634500003350 protein binding site [polypeptide binding]; other site 634500003351 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 634500003352 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 634500003353 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 634500003354 hypothetical protein; Provisional; Region: PRK13677 634500003355 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 634500003356 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 634500003357 trimer interface [polypeptide binding]; other site 634500003358 active site 634500003359 substrate binding site [chemical binding]; other site 634500003360 CoA binding site [chemical binding]; other site 634500003361 PII uridylyl-transferase; Provisional; Region: PRK05007 634500003362 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 634500003363 metal binding triad; other site 634500003364 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 634500003365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500003366 Zn2+ binding site [ion binding]; other site 634500003367 Mg2+ binding site [ion binding]; other site 634500003368 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 634500003369 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 634500003370 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 634500003371 active site 634500003372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 634500003373 rRNA interaction site [nucleotide binding]; other site 634500003374 S8 interaction site; other site 634500003375 putative laminin-1 binding site; other site 634500003376 elongation factor Ts; Provisional; Region: tsf; PRK09377 634500003377 UBA/TS-N domain; Region: UBA; pfam00627 634500003378 Elongation factor TS; Region: EF_TS; pfam00889 634500003379 Elongation factor TS; Region: EF_TS; pfam00889 634500003380 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 634500003381 putative nucleotide binding site [chemical binding]; other site 634500003382 uridine monophosphate binding site [chemical binding]; other site 634500003383 homohexameric interface [polypeptide binding]; other site 634500003384 ribosome recycling factor; Reviewed; Region: frr; PRK00083 634500003385 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 634500003386 hinge region; other site 634500003387 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 634500003388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 634500003389 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 634500003390 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 634500003391 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 634500003392 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 634500003393 catalytic residue [active] 634500003394 putative FPP diphosphate binding site; other site 634500003395 putative FPP binding hydrophobic cleft; other site 634500003396 dimer interface [polypeptide binding]; other site 634500003397 putative IPP diphosphate binding site; other site 634500003398 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 634500003399 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 634500003400 zinc metallopeptidase RseP; Provisional; Region: PRK10779 634500003401 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 634500003402 active site 634500003403 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 634500003404 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 634500003405 protein binding site [polypeptide binding]; other site 634500003406 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 634500003407 putative substrate binding region [chemical binding]; other site 634500003408 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 634500003409 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500003410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500003411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500003412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500003413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 634500003414 Surface antigen; Region: Bac_surface_Ag; pfam01103 634500003415 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 634500003416 periplasmic chaperone; Provisional; Region: PRK10780 634500003417 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 634500003418 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 634500003419 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 634500003420 trimer interface [polypeptide binding]; other site 634500003421 active site 634500003422 UDP-GlcNAc binding site [chemical binding]; other site 634500003423 lipid binding site [chemical binding]; lipid-binding site 634500003424 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 634500003425 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 634500003426 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 634500003427 active site 634500003428 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 634500003429 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 634500003430 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 634500003431 RNA/DNA hybrid binding site [nucleotide binding]; other site 634500003432 active site 634500003433 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 634500003434 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 634500003435 putative active site [active] 634500003436 putative PHP Thumb interface [polypeptide binding]; other site 634500003437 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 634500003438 generic binding surface I; other site 634500003439 generic binding surface II; other site 634500003440 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 634500003441 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 634500003442 lysine decarboxylase LdcC; Provisional; Region: PRK15399 634500003443 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 634500003444 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 634500003445 homodimer interface [polypeptide binding]; other site 634500003446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500003447 catalytic residue [active] 634500003448 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 634500003449 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 634500003450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500003451 putative metal binding site [ion binding]; other site 634500003452 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 634500003453 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 634500003454 Ligand Binding Site [chemical binding]; other site 634500003455 TilS substrate binding domain; Region: TilS; pfam09179 634500003456 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 634500003457 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 634500003458 YaeQ protein; Region: YaeQ; pfam07152 634500003459 hypothetical protein; Provisional; Region: PRK09256 634500003460 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 634500003461 prolyl-tRNA synthetase; Provisional; Region: PRK09194 634500003462 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 634500003463 dimer interface [polypeptide binding]; other site 634500003464 motif 1; other site 634500003465 active site 634500003466 motif 2; other site 634500003467 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 634500003468 putative deacylase active site [active] 634500003469 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 634500003470 active site 634500003471 motif 3; other site 634500003472 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 634500003473 anticodon binding site; other site 634500003474 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 634500003475 homodimer interaction site [polypeptide binding]; other site 634500003476 cofactor binding site; other site 634500003477 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 634500003478 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 634500003479 lipoprotein, YaeC family; Region: TIGR00363 634500003480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003481 dimer interface [polypeptide binding]; other site 634500003482 conserved gate region; other site 634500003483 ABC-ATPase subunit interface; other site 634500003484 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634500003485 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634500003486 Walker A/P-loop; other site 634500003487 ATP binding site [chemical binding]; other site 634500003488 Q-loop/lid; other site 634500003489 ABC transporter signature motif; other site 634500003490 Walker B; other site 634500003491 D-loop; other site 634500003492 H-loop/switch region; other site 634500003493 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 634500003494 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 634500003495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500003496 active site 634500003497 motif I; other site 634500003498 motif II; other site 634500003499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500003500 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500003501 active site 634500003502 catalytic tetrad [active] 634500003503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500003504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500003505 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 634500003506 putative effector binding pocket; other site 634500003507 dimerization interface [polypeptide binding]; other site 634500003508 hypothetical protein; Provisional; Region: PRK05421 634500003509 putative catalytic site [active] 634500003510 putative metal binding site [ion binding]; other site 634500003511 putative phosphate binding site [ion binding]; other site 634500003512 putative catalytic site [active] 634500003513 putative phosphate binding site [ion binding]; other site 634500003514 putative metal binding site [ion binding]; other site 634500003515 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634500003516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500003517 S-adenosylmethionine binding site [chemical binding]; other site 634500003518 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 634500003519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003520 D-galactonate transporter; Region: 2A0114; TIGR00893 634500003521 putative substrate translocation pore; other site 634500003522 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 634500003523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500003524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500003525 catalytic residue [active] 634500003526 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500003527 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500003528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 634500003529 Methyltransferase domain; Region: Methyltransf_11; pfam08241 634500003530 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 634500003531 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 634500003532 active site 634500003533 catalytic site [active] 634500003534 substrate binding site [chemical binding]; other site 634500003535 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 634500003536 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 634500003537 Na binding site [ion binding]; other site 634500003538 putative substrate binding site [chemical binding]; other site 634500003539 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500003540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500003541 DNA-binding site [nucleotide binding]; DNA binding site 634500003542 FCD domain; Region: FCD; pfam07729 634500003543 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 634500003544 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 634500003545 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 634500003546 active site 634500003547 catalytic site [active] 634500003548 tetramer interface [polypeptide binding]; other site 634500003549 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 634500003550 amidase; Provisional; Region: PRK09201 634500003551 Amidase; Region: Amidase; cl11426 634500003552 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 634500003553 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 634500003554 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 634500003555 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634500003556 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500003557 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500003558 putative active site [active] 634500003559 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500003560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500003561 substrate binding pocket [chemical binding]; other site 634500003562 membrane-bound complex binding site; other site 634500003563 hinge residues; other site 634500003564 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500003565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003566 dimer interface [polypeptide binding]; other site 634500003567 conserved gate region; other site 634500003568 putative PBP binding loops; other site 634500003569 ABC-ATPase subunit interface; other site 634500003570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500003571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003572 dimer interface [polypeptide binding]; other site 634500003573 conserved gate region; other site 634500003574 putative PBP binding loops; other site 634500003575 ABC-ATPase subunit interface; other site 634500003576 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500003577 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500003578 Walker A/P-loop; other site 634500003579 ATP binding site [chemical binding]; other site 634500003580 Q-loop/lid; other site 634500003581 ABC transporter signature motif; other site 634500003582 Walker B; other site 634500003583 D-loop; other site 634500003584 H-loop/switch region; other site 634500003585 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 634500003586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500003587 catalytic residue [active] 634500003588 allantoate amidohydrolase; Reviewed; Region: PRK09290 634500003589 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 634500003590 active site 634500003591 metal binding site [ion binding]; metal-binding site 634500003592 dimer interface [polypeptide binding]; other site 634500003593 OHCU decarboxylase; Region: UraD_2; TIGR03180 634500003594 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 634500003595 active site 634500003596 homotetramer interface [polypeptide binding]; other site 634500003597 C-N hydrolase family amidase; Provisional; Region: PRK10438 634500003598 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 634500003599 active site 634500003600 catalytic triad [active] 634500003601 dimer interface [polypeptide binding]; other site 634500003602 methionine aminotransferase; Validated; Region: PRK09082 634500003603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500003604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500003605 homodimer interface [polypeptide binding]; other site 634500003606 catalytic residue [active] 634500003607 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 634500003608 intersubunit interface [polypeptide binding]; other site 634500003609 active site 634500003610 Zn2+ binding site [ion binding]; other site 634500003611 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 634500003612 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 634500003613 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 634500003614 Cupin domain; Region: Cupin_2; cl17218 634500003615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500003616 non-specific DNA binding site [nucleotide binding]; other site 634500003617 salt bridge; other site 634500003618 sequence-specific DNA binding site [nucleotide binding]; other site 634500003619 Bacitracin resistance protein BacA; Region: BacA; pfam02673 634500003620 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 634500003621 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 634500003622 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 634500003623 Phosphotransferase enzyme family; Region: APH; pfam01636 634500003624 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 634500003625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 634500003626 active site 634500003627 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 634500003628 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 634500003629 dimer interface [polypeptide binding]; other site 634500003630 active site 634500003631 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 634500003632 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 634500003633 putative active site [active] 634500003634 putative dimer interface [polypeptide binding]; other site 634500003635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 634500003636 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 634500003637 active site 634500003638 DNA polymerase IV; Validated; Region: PRK02406 634500003639 DNA binding site [nucleotide binding] 634500003640 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 634500003641 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 634500003642 metal binding site [ion binding]; metal-binding site 634500003643 dimer interface [polypeptide binding]; other site 634500003644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500003645 active site 634500003646 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 634500003647 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 634500003648 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500003649 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500003650 trimer interface [polypeptide binding]; other site 634500003651 eyelet of channel; other site 634500003652 gamma-glutamyl kinase; Provisional; Region: PRK05429 634500003653 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 634500003654 nucleotide binding site [chemical binding]; other site 634500003655 homotetrameric interface [polypeptide binding]; other site 634500003656 putative phosphate binding site [ion binding]; other site 634500003657 putative allosteric binding site; other site 634500003658 PUA domain; Region: PUA; pfam01472 634500003659 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 634500003660 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 634500003661 putative catalytic cysteine [active] 634500003662 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634500003663 MarR family; Region: MarR_2; cl17246 634500003664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634500003665 putative cyanate transporter; Provisional; Region: cynX; PRK09705 634500003666 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 634500003667 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500003668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500003669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500003670 MFS/sugar transport protein; Region: MFS_2; pfam13347 634500003671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003672 putative substrate translocation pore; other site 634500003673 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 634500003674 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 634500003675 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 634500003676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500003677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500003678 non-specific DNA binding site [nucleotide binding]; other site 634500003679 salt bridge; other site 634500003680 sequence-specific DNA binding site [nucleotide binding]; other site 634500003681 Cupin domain; Region: Cupin_2; cl17218 634500003682 AzlC protein; Region: AzlC; cl00570 634500003683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500003684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500003685 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500003686 putative effector binding pocket; other site 634500003687 dimerization interface [polypeptide binding]; other site 634500003688 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 634500003689 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 634500003690 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 634500003691 putative dimer interface [polypeptide binding]; other site 634500003692 N-terminal domain interface [polypeptide binding]; other site 634500003693 putative substrate binding pocket (H-site) [chemical binding]; other site 634500003694 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 634500003695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500003696 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 634500003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500003698 active site 634500003699 phosphorylation site [posttranslational modification] 634500003700 intermolecular recognition site; other site 634500003701 dimerization interface [polypeptide binding]; other site 634500003702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500003703 DNA binding site [nucleotide binding] 634500003704 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 634500003705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500003706 dimerization interface [polypeptide binding]; other site 634500003707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500003708 dimer interface [polypeptide binding]; other site 634500003709 phosphorylation site [posttranslational modification] 634500003710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500003711 ATP binding site [chemical binding]; other site 634500003712 Mg2+ binding site [ion binding]; other site 634500003713 G-X-G motif; other site 634500003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500003716 putative substrate translocation pore; other site 634500003717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500003718 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500003719 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 634500003720 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 634500003721 trimer interface [polypeptide binding]; other site 634500003722 active site 634500003723 substrate binding site [chemical binding]; other site 634500003724 CoA binding site [chemical binding]; other site 634500003725 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500003726 chromosome condensation membrane protein; Provisional; Region: PRK14196 634500003727 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 634500003728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003729 putative substrate translocation pore; other site 634500003730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003731 anti-RssB factor; Provisional; Region: PRK10244 634500003732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500003733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003734 dimer interface [polypeptide binding]; other site 634500003735 conserved gate region; other site 634500003736 putative PBP binding loops; other site 634500003737 ABC-ATPase subunit interface; other site 634500003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003739 dimer interface [polypeptide binding]; other site 634500003740 conserved gate region; other site 634500003741 putative PBP binding loops; other site 634500003742 ABC-ATPase subunit interface; other site 634500003743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634500003744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634500003745 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500003746 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 634500003747 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634500003748 Walker A/P-loop; other site 634500003749 ATP binding site [chemical binding]; other site 634500003750 Q-loop/lid; other site 634500003751 ABC transporter signature motif; other site 634500003752 Walker B; other site 634500003753 D-loop; other site 634500003754 H-loop/switch region; other site 634500003755 TOBE domain; Region: TOBE; pfam03459 634500003756 TOBE domain; Region: TOBE_2; pfam08402 634500003757 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 634500003758 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634500003759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500003760 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 634500003761 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500003762 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500003763 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500003764 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 634500003765 inhibitor site; inhibition site 634500003766 dihydrodipicolinate synthase; Region: dapA; TIGR00674 634500003767 active site 634500003768 dimer interface [polypeptide binding]; other site 634500003769 catalytic residue [active] 634500003770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500003771 S-adenosylmethionine binding site [chemical binding]; other site 634500003772 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 634500003773 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500003774 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 634500003775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 634500003776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500003777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 634500003778 Walker A/P-loop; other site 634500003779 ATP binding site [chemical binding]; other site 634500003780 Q-loop/lid; other site 634500003781 ABC transporter signature motif; other site 634500003782 Walker B; other site 634500003783 D-loop; other site 634500003784 H-loop/switch region; other site 634500003785 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500003786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500003787 Walker A/P-loop; other site 634500003788 ATP binding site [chemical binding]; other site 634500003789 Q-loop/lid; other site 634500003790 ABC transporter signature motif; other site 634500003791 Walker B; other site 634500003792 D-loop; other site 634500003793 H-loop/switch region; other site 634500003794 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 634500003795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003796 dimer interface [polypeptide binding]; other site 634500003797 conserved gate region; other site 634500003798 putative PBP binding loops; other site 634500003799 ABC-ATPase subunit interface; other site 634500003800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500003801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500003802 dimer interface [polypeptide binding]; other site 634500003803 conserved gate region; other site 634500003804 putative PBP binding loops; other site 634500003805 ABC-ATPase subunit interface; other site 634500003806 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500003807 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 634500003808 CAAX protease self-immunity; Region: Abi; pfam02517 634500003809 CHASE4 domain; Region: CHASE4; pfam05228 634500003810 PAS domain S-box; Region: sensory_box; TIGR00229 634500003811 PAS domain; Region: PAS; smart00091 634500003812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500003813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500003814 metal binding site [ion binding]; metal-binding site 634500003815 active site 634500003816 I-site; other site 634500003817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500003818 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 634500003819 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 634500003820 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634500003821 catalytic residues [active] 634500003822 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 634500003823 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 634500003824 catalytic residues [active] 634500003825 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 634500003826 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 634500003827 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 634500003828 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 634500003829 DsbD alpha interface [polypeptide binding]; other site 634500003830 catalytic residues [active] 634500003831 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500003832 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500003833 DNA-binding site [nucleotide binding]; DNA binding site 634500003834 RNA-binding motif; other site 634500003835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500003836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500003837 putative substrate translocation pore; other site 634500003838 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 634500003839 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 634500003840 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 634500003841 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 634500003842 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 634500003843 anti-RssB factor; Provisional; Region: PRK10244 634500003844 hypothetical protein; Provisional; Region: PRK11505 634500003845 psiF repeat; Region: PsiF_repeat; pfam07769 634500003846 psiF repeat; Region: PsiF_repeat; pfam07769 634500003847 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 634500003848 iron-sulfur cluster [ion binding]; other site 634500003849 [2Fe-2S] cluster binding site [ion binding]; other site 634500003850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 634500003851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500003852 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 634500003853 pyrroline-5-carboxylate reductase; Region: PLN02688 634500003854 hypothetical protein; Validated; Region: PRK00124 634500003855 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 634500003856 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 634500003857 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 634500003858 ADP binding site [chemical binding]; other site 634500003859 magnesium binding site [ion binding]; other site 634500003860 putative shikimate binding site; other site 634500003861 hypothetical protein; Provisional; Region: PRK10380 634500003862 hypothetical protein; Provisional; Region: PRK10481 634500003863 hypothetical protein; Provisional; Region: PRK10579 634500003864 recombination associated protein; Reviewed; Region: rdgC; PRK00321 634500003865 fructokinase; Reviewed; Region: PRK09557 634500003866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500003867 nucleotide binding site [chemical binding]; other site 634500003868 ethanolamine permease; Region: 2A0305; TIGR00908 634500003869 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 634500003870 active site 634500003871 substrate binding site [chemical binding]; other site 634500003872 Phosphotransferase enzyme family; Region: APH; pfam01636 634500003873 ATP binding site [chemical binding]; other site 634500003874 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 634500003875 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500003876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500003877 silverDB:661Eb01303 634500003878 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 634500003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 634500003880 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 634500003881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500003882 AAA domain; Region: AAA_23; pfam13476 634500003883 Walker A/P-loop; other site 634500003884 ATP binding site [chemical binding]; other site 634500003885 Q-loop/lid; other site 634500003886 exonuclease subunit SbcC; Provisional; Region: PRK10246 634500003887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500003888 ABC transporter signature motif; other site 634500003889 Walker B; other site 634500003890 D-loop; other site 634500003891 H-loop/switch region; other site 634500003892 exonuclease subunit SbcD; Provisional; Region: PRK10966 634500003893 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 634500003894 active site 634500003895 metal binding site [ion binding]; metal-binding site 634500003896 DNA binding site [nucleotide binding] 634500003897 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 634500003898 transcriptional regulator PhoB; Provisional; Region: PRK10161 634500003899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500003900 active site 634500003901 phosphorylation site [posttranslational modification] 634500003902 intermolecular recognition site; other site 634500003903 dimerization interface [polypeptide binding]; other site 634500003904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500003905 DNA binding site [nucleotide binding] 634500003906 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 634500003907 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 634500003908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500003909 putative active site [active] 634500003910 heme pocket [chemical binding]; other site 634500003911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500003912 dimer interface [polypeptide binding]; other site 634500003913 phosphorylation site [posttranslational modification] 634500003914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500003915 ATP binding site [chemical binding]; other site 634500003916 Mg2+ binding site [ion binding]; other site 634500003917 G-X-G motif; other site 634500003918 PBP superfamily domain; Region: PBP_like_2; cl17296 634500003919 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 634500003920 substrate binding site [chemical binding]; other site 634500003921 THF binding site; other site 634500003922 zinc-binding site [ion binding]; other site 634500003923 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 634500003924 putative proline-specific permease; Provisional; Region: proY; PRK10580 634500003925 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 634500003926 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 634500003927 catalytic core [active] 634500003928 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 634500003929 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500003930 peroxidase; Provisional; Region: PRK15000 634500003931 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 634500003932 dimer interface [polypeptide binding]; other site 634500003933 decamer (pentamer of dimers) interface [polypeptide binding]; other site 634500003934 catalytic triad [active] 634500003935 peroxidatic and resolving cysteines [active] 634500003936 Protein of unknown function, DUF479; Region: DUF479; cl01203 634500003937 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 634500003938 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 634500003939 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 634500003940 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 634500003941 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 634500003942 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 634500003943 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 634500003944 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 634500003945 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 634500003946 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 634500003947 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 634500003948 Protein export membrane protein; Region: SecD_SecF; pfam02355 634500003949 hypothetical protein; Provisional; Region: PRK11530 634500003950 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 634500003951 BON domain; Region: BON; pfam04972 634500003952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500003953 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 634500003954 ATP cone domain; Region: ATP-cone; pfam03477 634500003955 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 634500003956 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 634500003957 catalytic motif [active] 634500003958 Zn binding site [ion binding]; other site 634500003959 RibD C-terminal domain; Region: RibD_C; cl17279 634500003960 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 634500003961 homopentamer interface [polypeptide binding]; other site 634500003962 active site 634500003963 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 634500003964 putative RNA binding site [nucleotide binding]; other site 634500003965 thiamine monophosphate kinase; Provisional; Region: PRK05731 634500003966 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 634500003967 ATP binding site [chemical binding]; other site 634500003968 dimerization interface [polypeptide binding]; other site 634500003969 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 634500003970 tetramer interfaces [polypeptide binding]; other site 634500003971 binuclear metal-binding site [ion binding]; other site 634500003972 silverDB:661Eb01343 634500003973 silverDB:661Eb01345 634500003974 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 634500003975 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 634500003976 TPP-binding site; other site 634500003977 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634500003978 PYR/PP interface [polypeptide binding]; other site 634500003979 dimer interface [polypeptide binding]; other site 634500003980 TPP binding site [chemical binding]; other site 634500003981 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634500003982 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 634500003983 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 634500003984 substrate binding pocket [chemical binding]; other site 634500003985 chain length determination region; other site 634500003986 substrate-Mg2+ binding site; other site 634500003987 catalytic residues [active] 634500003988 aspartate-rich region 1; other site 634500003989 active site lid residues [active] 634500003990 aspartate-rich region 2; other site 634500003991 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 634500003992 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 634500003993 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 634500003994 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 634500003995 Ligand Binding Site [chemical binding]; other site 634500003996 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 634500003997 active site residue [active] 634500003998 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 634500003999 conserved cys residue [active] 634500004000 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 634500004001 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634500004002 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 634500004003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 634500004004 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 634500004005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500004007 putative substrate translocation pore; other site 634500004008 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 634500004009 UbiA prenyltransferase family; Region: UbiA; pfam01040 634500004010 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 634500004011 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 634500004012 Subunit I/III interface [polypeptide binding]; other site 634500004013 Subunit III/IV interface [polypeptide binding]; other site 634500004014 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 634500004015 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 634500004016 D-pathway; other site 634500004017 Putative ubiquinol binding site [chemical binding]; other site 634500004018 Low-spin heme (heme b) binding site [chemical binding]; other site 634500004019 Putative water exit pathway; other site 634500004020 Binuclear center (heme o3/CuB) [ion binding]; other site 634500004021 K-pathway; other site 634500004022 Putative proton exit pathway; other site 634500004023 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 634500004024 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 634500004025 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 634500004026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004027 putative substrate translocation pore; other site 634500004028 hypothetical protein; Provisional; Region: PRK11627 634500004029 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 634500004030 BolA-like protein; Region: BolA; cl00386 634500004031 trigger factor; Provisional; Region: tig; PRK01490 634500004032 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634500004033 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 634500004034 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 634500004035 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 634500004036 oligomer interface [polypeptide binding]; other site 634500004037 active site residues [active] 634500004038 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 634500004039 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 634500004040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500004041 Walker A motif; other site 634500004042 ATP binding site [chemical binding]; other site 634500004043 Walker B motif; other site 634500004044 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 634500004045 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 634500004046 Found in ATP-dependent protease La (LON); Region: LON; smart00464 634500004047 Found in ATP-dependent protease La (LON); Region: LON; smart00464 634500004048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500004049 Walker A motif; other site 634500004050 ATP binding site [chemical binding]; other site 634500004051 Walker B motif; other site 634500004052 arginine finger; other site 634500004053 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 634500004054 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 634500004055 IHF dimer interface [polypeptide binding]; other site 634500004056 IHF - DNA interface [nucleotide binding]; other site 634500004057 periplasmic folding chaperone; Provisional; Region: PRK10788 634500004058 SurA N-terminal domain; Region: SurA_N_3; cl07813 634500004059 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 634500004060 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 634500004061 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634500004062 active site 634500004063 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 634500004064 Ligand Binding Site [chemical binding]; other site 634500004065 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 634500004066 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 634500004067 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 634500004068 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 634500004069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500004070 active site 634500004071 motif I; other site 634500004072 motif II; other site 634500004073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 634500004074 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634500004075 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 634500004076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500004077 catalytic residue [active] 634500004078 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 634500004079 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 634500004080 AsnC family; Region: AsnC_trans_reg; pfam01037 634500004081 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 634500004082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500004083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500004084 Walker A/P-loop; other site 634500004085 ATP binding site [chemical binding]; other site 634500004086 Q-loop/lid; other site 634500004087 ABC transporter signature motif; other site 634500004088 Walker B; other site 634500004089 D-loop; other site 634500004090 H-loop/switch region; other site 634500004091 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 634500004092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500004093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500004094 Walker A/P-loop; other site 634500004095 ATP binding site [chemical binding]; other site 634500004096 Q-loop/lid; other site 634500004097 ABC transporter signature motif; other site 634500004098 Walker B; other site 634500004099 D-loop; other site 634500004100 H-loop/switch region; other site 634500004101 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 634500004102 Nitrogen regulatory protein P-II; Region: P-II; smart00938 634500004103 ammonium transporter; Provisional; Region: PRK10666 634500004104 acyl-CoA thioesterase II; Provisional; Region: PRK10526 634500004105 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 634500004106 active site 634500004107 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 634500004108 catalytic triad [active] 634500004109 dimer interface [polypeptide binding]; other site 634500004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 634500004111 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 634500004112 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 634500004113 DNA binding site [nucleotide binding] 634500004114 active site 634500004115 gene expression modulator; Provisional; Region: PRK10945 634500004116 Hha toxicity attenuator; Provisional; Region: PRK10667 634500004117 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 634500004118 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 634500004119 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 634500004120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500004121 ABC-ATPase subunit interface; other site 634500004122 dimer interface [polypeptide binding]; other site 634500004123 putative PBP binding regions; other site 634500004124 silverDB:661Eb01395 634500004125 silverDB:661Eb01396 634500004126 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 634500004127 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 634500004128 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 634500004129 Protein export membrane protein; Region: SecD_SecF; cl14618 634500004130 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 634500004131 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500004132 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500004133 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 634500004134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500004135 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 634500004136 hypothetical protein; Provisional; Region: PRK11038 634500004137 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 634500004138 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 634500004139 hypothetical protein; Provisional; Region: PRK10527 634500004140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500004141 active site 634500004142 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 634500004143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500004144 Walker A motif; other site 634500004145 ATP binding site [chemical binding]; other site 634500004146 Walker B motif; other site 634500004147 arginine finger; other site 634500004148 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 634500004149 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 634500004150 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 634500004151 hypothetical protein; Validated; Region: PRK00153 634500004152 recombination protein RecR; Reviewed; Region: recR; PRK00076 634500004153 RecR protein; Region: RecR; pfam02132 634500004154 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 634500004155 putative active site [active] 634500004156 putative metal-binding site [ion binding]; other site 634500004157 tetramer interface [polypeptide binding]; other site 634500004158 heat shock protein 90; Provisional; Region: PRK05218 634500004159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500004160 ATP binding site [chemical binding]; other site 634500004161 Mg2+ binding site [ion binding]; other site 634500004162 G-X-G motif; other site 634500004163 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 634500004164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500004165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500004166 dimerization interface [polypeptide binding]; other site 634500004167 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 634500004168 Ligand Binding Site [chemical binding]; other site 634500004169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 634500004170 nudix motif; other site 634500004171 adenylate kinase; Reviewed; Region: adk; PRK00279 634500004172 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 634500004173 AMP-binding site [chemical binding]; other site 634500004174 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 634500004175 ferrochelatase; Reviewed; Region: hemH; PRK00035 634500004176 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 634500004177 C-terminal domain interface [polypeptide binding]; other site 634500004178 active site 634500004179 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 634500004180 active site 634500004181 N-terminal domain interface [polypeptide binding]; other site 634500004182 inosine/guanosine kinase; Provisional; Region: PRK15074 634500004183 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500004184 substrate binding site [chemical binding]; other site 634500004185 ATP binding site [chemical binding]; other site 634500004186 putative cation:proton antiport protein; Provisional; Region: PRK10669 634500004187 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 634500004188 TrkA-N domain; Region: TrkA_N; pfam02254 634500004189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500004191 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 634500004192 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 634500004193 active site 634500004194 metal binding site [ion binding]; metal-binding site 634500004195 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 634500004196 Predicted membrane protein [Function unknown]; Region: COG4125 634500004197 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 634500004198 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 634500004199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500004200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500004201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500004202 dimerization interface [polypeptide binding]; other site 634500004203 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 634500004204 putative deacylase active site [active] 634500004205 TraB family; Region: TraB; cl12050 634500004206 copper exporting ATPase; Provisional; Region: copA; PRK10671 634500004207 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634500004208 metal-binding site [ion binding] 634500004209 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634500004210 metal-binding site [ion binding] 634500004211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500004212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500004213 motif II; other site 634500004214 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 634500004215 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 634500004216 DNA binding residues [nucleotide binding] 634500004217 dimer interface [polypeptide binding]; other site 634500004218 copper binding site [ion binding]; other site 634500004219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004220 DNA-binding site [nucleotide binding]; DNA binding site 634500004221 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 634500004222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004223 DNA-binding site [nucleotide binding]; DNA binding site 634500004224 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500004225 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 634500004226 active site 634500004227 catalytic site [active] 634500004228 Zn binding site [ion binding]; other site 634500004229 tetramer interface [polypeptide binding]; other site 634500004230 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 634500004231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004232 benzoate transport; Region: 2A0115; TIGR00895 634500004233 putative substrate translocation pore; other site 634500004234 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 634500004235 classical (c) SDRs; Region: SDR_c; cd05233 634500004236 NAD(P) binding site [chemical binding]; other site 634500004237 active site 634500004238 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634500004239 classical (c) SDRs; Region: SDR_c; cd05233 634500004240 NAD(P) binding site [chemical binding]; other site 634500004241 active site 634500004242 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 634500004243 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634500004244 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 634500004245 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634500004246 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 634500004247 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 634500004248 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 634500004249 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 634500004250 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 634500004251 oxidoreductase; Provisional; Region: PRK08017 634500004252 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 634500004253 NADP binding site [chemical binding]; other site 634500004254 active site 634500004255 steroid binding site; other site 634500004256 integrase; Provisional; Region: int; PHA02601 634500004257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 634500004258 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634500004259 active site 634500004260 DNA binding site [nucleotide binding] 634500004261 Int/Topo IB signature motif; other site 634500004262 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 634500004263 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 634500004264 DNA binding residues [nucleotide binding] 634500004265 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 634500004266 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 634500004267 DksA-like zinc finger domain containing protein; Region: PHA00080 634500004268 DNA adenine methylase (dam); Region: dam; TIGR00571 634500004269 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 634500004270 portal vertex protein; Provisional; Region: Q; PHA02536 634500004271 Phage portal protein; Region: Phage_portal; pfam04860 634500004272 terminase ATPase subunit; Provisional; Region: P; PHA02535 634500004273 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 634500004274 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 634500004275 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 634500004276 capsid protein; Provisional; Region: N; PHA02538 634500004277 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 634500004278 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 634500004279 Phage Tail Protein X; Region: Phage_tail_X; cl02088 634500004280 intramembrane serine protease GlpG; Provisional; Region: PRK10907 634500004281 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 634500004282 catalytic residues [active] 634500004283 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 634500004284 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 634500004285 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 634500004286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500004287 AAA domain; Region: AAA_21; pfam13304 634500004288 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500004289 Walker A motif; other site 634500004290 Walker A/P-loop; other site 634500004291 ATP binding site [chemical binding]; other site 634500004292 ATP binding site [chemical binding]; other site 634500004293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 634500004294 Q-loop/lid; other site 634500004295 ABC transporter signature motif; other site 634500004296 Walker B; other site 634500004297 D-loop; other site 634500004298 H-loop/switch region; other site 634500004299 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 634500004300 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 634500004301 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 634500004302 Baseplate J-like protein; Region: Baseplate_J; cl01294 634500004303 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 634500004304 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 634500004305 Phage Tail Collar Domain; Region: Collar; pfam07484 634500004306 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 634500004307 major tail sheath protein; Provisional; Region: FI; PHA02560 634500004308 major tail tube protein; Provisional; Region: FII; PHA02600 634500004309 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 634500004310 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 634500004311 Phage protein U [General function prediction only]; Region: COG3499 634500004312 tail protein; Provisional; Region: D; PHA02561 634500004313 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 634500004314 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 634500004315 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 634500004316 active site 634500004317 catalytic triad [active] 634500004318 oxyanion hole [active] 634500004319 switch loop; other site 634500004320 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 634500004321 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 634500004322 Walker A/P-loop; other site 634500004323 ATP binding site [chemical binding]; other site 634500004324 Q-loop/lid; other site 634500004325 ABC transporter signature motif; other site 634500004326 Walker B; other site 634500004327 D-loop; other site 634500004328 H-loop/switch region; other site 634500004329 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 634500004330 FtsX-like permease family; Region: FtsX; pfam02687 634500004331 Autoinducer synthetase; Region: Autoind_synth; pfam00765 634500004332 Autoinducer binding domain; Region: Autoind_bind; pfam03472 634500004333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500004334 DNA binding residues [nucleotide binding] 634500004335 dimerization interface [polypeptide binding]; other site 634500004336 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 634500004337 ATP-grasp domain; Region: ATP-grasp; pfam02222 634500004338 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 634500004339 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 634500004340 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500004341 putative active site [active] 634500004342 putative metal binding site [ion binding]; other site 634500004343 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 634500004344 substrate binding site [chemical binding]; other site 634500004345 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 634500004346 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 634500004347 active site 634500004348 HIGH motif; other site 634500004349 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 634500004350 KMSKS motif; other site 634500004351 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 634500004352 tRNA binding surface [nucleotide binding]; other site 634500004353 anticodon binding site; other site 634500004354 Predicted ATPase [General function prediction only]; Region: COG4637 634500004355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500004356 Walker A/P-loop; other site 634500004357 ATP binding site [chemical binding]; other site 634500004358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500004359 RNA binding surface [nucleotide binding]; other site 634500004360 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 634500004361 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 634500004362 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 634500004363 homodimer interface [polypeptide binding]; other site 634500004364 NADP binding site [chemical binding]; other site 634500004365 substrate binding site [chemical binding]; other site 634500004366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 634500004367 DNA binding site [nucleotide binding] 634500004368 active site 634500004369 Int/Topo IB signature motif; other site 634500004370 Fimbrial protein; Region: Fimbrial; cl01416 634500004371 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 634500004372 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 634500004373 outer membrane usher protein; Provisional; Region: PRK15193 634500004374 PapC N-terminal domain; Region: PapC_N; pfam13954 634500004375 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500004376 PapC C-terminal domain; Region: PapC_C; pfam13953 634500004377 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 634500004378 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500004379 active site 634500004380 phosphorylation site [posttranslational modification] 634500004381 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 634500004382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004383 putative substrate translocation pore; other site 634500004384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004385 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 634500004386 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500004387 N-terminal plug; other site 634500004388 ligand-binding site [chemical binding]; other site 634500004389 RNA polymerase sigma factor; Provisional; Region: PRK12512 634500004390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500004391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500004392 DNA binding residues [nucleotide binding] 634500004393 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 634500004394 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 634500004395 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 634500004396 DsbD alpha interface [polypeptide binding]; other site 634500004397 catalytic residues [active] 634500004398 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 634500004399 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 634500004400 catalytic triad [active] 634500004401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004402 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500004403 putative substrate translocation pore; other site 634500004404 amidase; Provisional; Region: PRK07056 634500004405 Amidase; Region: Amidase; cl11426 634500004406 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 634500004407 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500004408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004409 DNA-binding site [nucleotide binding]; DNA binding site 634500004410 FCD domain; Region: FCD; pfam07729 634500004411 anti-RssB factor; Provisional; Region: PRK10244 634500004412 zinc/cadmium-binding protein; Provisional; Region: PRK10306 634500004413 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500004414 homotrimer interaction site [polypeptide binding]; other site 634500004415 putative active site [active] 634500004416 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 634500004417 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500004418 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500004419 active site 634500004420 catalytic tetrad [active] 634500004421 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500004422 homotrimer interaction site [polypeptide binding]; other site 634500004423 putative active site [active] 634500004424 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634500004425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500004426 TM-ABC transporter signature motif; other site 634500004427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500004428 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634500004429 TM-ABC transporter signature motif; other site 634500004430 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 634500004431 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500004432 Walker A/P-loop; other site 634500004433 ATP binding site [chemical binding]; other site 634500004434 Q-loop/lid; other site 634500004435 ABC transporter signature motif; other site 634500004436 Walker B; other site 634500004437 D-loop; other site 634500004438 H-loop/switch region; other site 634500004439 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500004440 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 634500004441 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 634500004442 ligand binding site [chemical binding]; other site 634500004443 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 634500004444 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500004445 dimer interface [polypeptide binding]; other site 634500004446 active site 634500004447 non-prolyl cis peptide bond; other site 634500004448 insertion regions; other site 634500004449 pyrimidine utilization protein D; Region: RutD; TIGR03611 634500004450 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500004451 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 634500004452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500004453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500004454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500004455 dimerization interface [polypeptide binding]; other site 634500004456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 634500004457 heme pocket [chemical binding]; other site 634500004458 PAS domain S-box; Region: sensory_box; TIGR00229 634500004459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500004460 putative active site [active] 634500004461 heme pocket [chemical binding]; other site 634500004462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500004463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500004464 metal binding site [ion binding]; metal-binding site 634500004465 active site 634500004466 I-site; other site 634500004467 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 634500004468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500004469 NAD(P) binding site [chemical binding]; other site 634500004470 extended (e) SDRs; Region: SDR_e; cd08946 634500004471 NAD(P) binding site [chemical binding]; other site 634500004472 active site 634500004473 active site 634500004474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500004475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500004476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500004477 dimerization interface [polypeptide binding]; other site 634500004478 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 634500004479 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500004480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004481 DNA-binding site [nucleotide binding]; DNA binding site 634500004482 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500004483 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 634500004484 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 634500004485 dimer interface [polypeptide binding]; other site 634500004486 ADP-ribose binding site [chemical binding]; other site 634500004487 active site 634500004488 nudix motif; other site 634500004489 metal binding site [ion binding]; metal-binding site 634500004490 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 634500004491 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 634500004492 dimer interface [polypeptide binding]; other site 634500004493 ligand binding site [chemical binding]; other site 634500004494 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 634500004495 silverDB:661Eb01579 634500004496 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 634500004497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500004498 Helix-turn-helix domain; Region: HTH_18; pfam12833 634500004499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500004500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500004501 Coenzyme A binding pocket [chemical binding]; other site 634500004502 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500004503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004504 DNA-binding site [nucleotide binding]; DNA binding site 634500004505 FCD domain; Region: FCD; pfam07729 634500004506 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 634500004507 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 634500004508 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 634500004509 potential catalytic triad [active] 634500004510 conserved cys residue [active] 634500004511 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 634500004512 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500004513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500004514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500004515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500004516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500004517 DNA binding residues [nucleotide binding] 634500004518 dimerization interface [polypeptide binding]; other site 634500004519 D-galactonate transporter; Region: 2A0114; TIGR00893 634500004520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500004521 putative substrate translocation pore; other site 634500004522 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 634500004523 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 634500004524 active site 634500004525 tetramer interface [polypeptide binding]; other site 634500004526 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 634500004527 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 634500004528 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 634500004529 malate:quinone oxidoreductase; Validated; Region: PRK05257 634500004530 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 634500004531 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 634500004532 active site 634500004533 homopentamer interface [polypeptide binding]; other site 634500004534 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 634500004535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004536 DNA-binding site [nucleotide binding]; DNA binding site 634500004537 FCD domain; Region: FCD; pfam07729 634500004538 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 634500004539 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634500004540 phosphate binding site [ion binding]; other site 634500004541 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 634500004542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500004543 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 634500004544 active site 634500004545 phosphorylation site [posttranslational modification] 634500004546 intermolecular recognition site; other site 634500004547 dimerization interface [polypeptide binding]; other site 634500004548 TspO/MBR family; Region: TspO_MBR; pfam03073 634500004549 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 634500004550 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 634500004551 catalytic residues [active] 634500004552 EamA-like transporter family; Region: EamA; pfam00892 634500004553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500004554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500004555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500004556 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 634500004557 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634500004558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500004559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500004560 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500004561 Cytochrome c; Region: Cytochrom_C; pfam00034 634500004562 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500004563 Cytochrome c; Region: Cytochrom_C; pfam00034 634500004564 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 634500004565 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 634500004566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500004567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500004568 dimer interface [polypeptide binding]; other site 634500004569 putative CheW interface [polypeptide binding]; other site 634500004570 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 634500004571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634500004572 classical (c) SDRs; Region: SDR_c; cd05233 634500004573 NAD(P) binding site [chemical binding]; other site 634500004574 active site 634500004575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500004576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500004577 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500004578 putative effector binding pocket; other site 634500004579 putative dimerization interface [polypeptide binding]; other site 634500004580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500004581 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500004582 active site 634500004583 catalytic tetrad [active] 634500004584 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 634500004585 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 634500004586 active site 634500004587 NAD binding site [chemical binding]; other site 634500004588 metal binding site [ion binding]; metal-binding site 634500004589 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 634500004590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500004591 N-terminal plug; other site 634500004592 ligand-binding site [chemical binding]; other site 634500004593 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 634500004594 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 634500004595 Trp docking motif [polypeptide binding]; other site 634500004596 putative active site [active] 634500004597 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 634500004598 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 634500004599 inhibitor-cofactor binding pocket; inhibition site 634500004600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500004601 catalytic residue [active] 634500004602 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 634500004603 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 634500004604 Ligand binding site; other site 634500004605 Putative Catalytic site; other site 634500004606 DXD motif; other site 634500004607 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 634500004608 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 634500004609 active site 634500004610 substrate binding site [chemical binding]; other site 634500004611 cosubstrate binding site; other site 634500004612 catalytic site [active] 634500004613 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 634500004614 active site 634500004615 hexamer interface [polypeptide binding]; other site 634500004616 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 634500004617 NAD binding site [chemical binding]; other site 634500004618 substrate binding site [chemical binding]; other site 634500004619 active site 634500004620 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 634500004621 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 634500004622 putative active site [active] 634500004623 putative catalytic site [active] 634500004624 putative Zn binding site [ion binding]; other site 634500004625 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 634500004626 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 634500004627 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 634500004628 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 634500004629 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 634500004630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500004631 active site 634500004632 phosphorylation site [posttranslational modification] 634500004633 intermolecular recognition site; other site 634500004634 dimerization interface [polypeptide binding]; other site 634500004635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500004636 DNA binding site [nucleotide binding] 634500004637 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 634500004638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 634500004639 Walker A/P-loop; other site 634500004640 ATP binding site [chemical binding]; other site 634500004641 Q-loop/lid; other site 634500004642 ABC transporter signature motif; other site 634500004643 Walker B; other site 634500004644 D-loop; other site 634500004645 H-loop/switch region; other site 634500004646 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 634500004647 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 634500004648 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 634500004649 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 634500004650 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 634500004651 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 634500004652 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 634500004653 high-affinity gluconate transporter; Provisional; Region: PRK14984 634500004654 gluconate transporter; Region: gntP; TIGR00791 634500004655 putative metal dependent hydrolase; Provisional; Region: PRK11598 634500004656 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 634500004657 Sulfatase; Region: Sulfatase; pfam00884 634500004658 silverDB:661Eb01654 634500004659 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 634500004660 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 634500004661 putative C-terminal domain interface [polypeptide binding]; other site 634500004662 putative GSH binding site (G-site) [chemical binding]; other site 634500004663 putative dimer interface [polypeptide binding]; other site 634500004664 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 634500004665 putative N-terminal domain interface [polypeptide binding]; other site 634500004666 putative dimer interface [polypeptide binding]; other site 634500004667 putative substrate binding pocket (H-site) [chemical binding]; other site 634500004668 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 634500004669 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500004670 DNA-binding site [nucleotide binding]; DNA binding site 634500004671 RNA-binding motif; other site 634500004672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500004674 Coenzyme A binding pocket [chemical binding]; other site 634500004675 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500004676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500004677 DNA-binding site [nucleotide binding]; DNA binding site 634500004678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500004679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500004680 homodimer interface [polypeptide binding]; other site 634500004681 catalytic residue [active] 634500004682 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 634500004683 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634500004684 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 634500004685 putative active site [active] 634500004686 catalytic triad [active] 634500004687 putative dimer interface [polypeptide binding]; other site 634500004688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500004689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500004690 substrate binding pocket [chemical binding]; other site 634500004691 membrane-bound complex binding site; other site 634500004692 hinge residues; other site 634500004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500004694 dimer interface [polypeptide binding]; other site 634500004695 conserved gate region; other site 634500004696 putative PBP binding loops; other site 634500004697 ABC-ATPase subunit interface; other site 634500004698 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500004699 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500004700 Walker A/P-loop; other site 634500004701 ATP binding site [chemical binding]; other site 634500004702 Q-loop/lid; other site 634500004703 ABC transporter signature motif; other site 634500004704 Walker B; other site 634500004705 D-loop; other site 634500004706 H-loop/switch region; other site 634500004707 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 634500004708 lipoyl synthase; Provisional; Region: PRK05481 634500004709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500004710 FeS/SAM binding site; other site 634500004711 lipoate-protein ligase B; Provisional; Region: PRK14342 634500004712 hypothetical protein; Provisional; Region: PRK04998 634500004713 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 634500004714 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634500004715 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 634500004716 rare lipoprotein A; Provisional; Region: PRK10672 634500004717 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 634500004718 Sporulation related domain; Region: SPOR; pfam05036 634500004719 cell wall shape-determining protein; Provisional; Region: PRK10794 634500004720 penicillin-binding protein 2; Provisional; Region: PRK10795 634500004721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634500004722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634500004723 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 634500004724 Oligomerisation domain; Region: Oligomerisation; cl00519 634500004725 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 634500004726 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 634500004727 active site 634500004728 (T/H)XGH motif; other site 634500004729 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 634500004730 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 634500004731 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 634500004732 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 634500004733 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 634500004734 HIGH motif; other site 634500004735 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 634500004736 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 634500004737 active site 634500004738 KMSKS motif; other site 634500004739 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 634500004740 tRNA binding surface [nucleotide binding]; other site 634500004741 hypothetical protein; Provisional; Region: PRK11032 634500004742 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500004743 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500004744 Walker A/P-loop; other site 634500004745 ATP binding site [chemical binding]; other site 634500004746 Q-loop/lid; other site 634500004747 ABC transporter signature motif; other site 634500004748 Walker B; other site 634500004749 D-loop; other site 634500004750 H-loop/switch region; other site 634500004751 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500004752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500004753 dimer interface [polypeptide binding]; other site 634500004754 conserved gate region; other site 634500004755 putative PBP binding loops; other site 634500004756 ABC-ATPase subunit interface; other site 634500004757 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500004758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500004759 dimer interface [polypeptide binding]; other site 634500004760 conserved gate region; other site 634500004761 putative PBP binding loops; other site 634500004762 ABC-ATPase subunit interface; other site 634500004763 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 634500004764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500004765 substrate binding pocket [chemical binding]; other site 634500004766 membrane-bound complex binding site; other site 634500004767 hinge residues; other site 634500004768 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 634500004769 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 634500004770 putative active site [active] 634500004771 catalytic triad [active] 634500004772 putative dimer interface [polypeptide binding]; other site 634500004773 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 634500004774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634500004775 Transporter associated domain; Region: CorC_HlyC; smart01091 634500004776 metal-binding heat shock protein; Provisional; Region: PRK00016 634500004777 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 634500004778 PhoH-like protein; Region: PhoH; pfam02562 634500004779 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 634500004780 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 634500004781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500004782 FeS/SAM binding site; other site 634500004783 TRAM domain; Region: TRAM; pfam01938 634500004784 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 634500004785 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 634500004786 asparagine synthetase B; Provisional; Region: asnB; PRK09431 634500004787 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 634500004788 active site 634500004789 dimer interface [polypeptide binding]; other site 634500004790 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 634500004791 Ligand Binding Site [chemical binding]; other site 634500004792 Molecular Tunnel; other site 634500004793 UMP phosphatase; Provisional; Region: PRK10444 634500004794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500004795 active site 634500004796 motif I; other site 634500004797 motif II; other site 634500004798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500004799 MarR family; Region: MarR; pfam01047 634500004800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634500004801 ROK family; Region: ROK; pfam00480 634500004802 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 634500004803 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 634500004804 active site 634500004805 dimer interface [polypeptide binding]; other site 634500004806 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 634500004807 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 634500004808 active site 634500004809 trimer interface [polypeptide binding]; other site 634500004810 allosteric site; other site 634500004811 active site lid [active] 634500004812 hexamer (dimer of trimers) interface [polypeptide binding]; other site 634500004813 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500004814 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 634500004815 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500004816 active site turn [active] 634500004817 phosphorylation site [posttranslational modification] 634500004818 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 634500004819 HPr interaction site; other site 634500004820 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634500004821 active site 634500004822 phosphorylation site [posttranslational modification] 634500004823 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 634500004824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 634500004825 active site 634500004826 HIGH motif; other site 634500004827 nucleotide binding site [chemical binding]; other site 634500004828 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 634500004829 KMSKS motif; other site 634500004830 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 634500004831 outer membrane porin, OprD family; Region: OprD; pfam03573 634500004832 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 634500004833 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 634500004834 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 634500004835 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 634500004836 active site 634500004837 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 634500004838 ferric uptake regulator; Provisional; Region: fur; PRK09462 634500004839 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 634500004840 metal binding site 2 [ion binding]; metal-binding site 634500004841 putative DNA binding helix; other site 634500004842 metal binding site 1 [ion binding]; metal-binding site 634500004843 dimer interface [polypeptide binding]; other site 634500004844 structural Zn2+ binding site [ion binding]; other site 634500004845 flavodoxin FldA; Validated; Region: PRK09267 634500004846 LexA regulated protein; Provisional; Region: PRK11675 634500004847 acyl-CoA esterase; Provisional; Region: PRK10673 634500004848 PGAP1-like protein; Region: PGAP1; pfam07819 634500004849 replication initiation regulator SeqA; Provisional; Region: PRK11187 634500004850 phosphoglucomutase; Validated; Region: PRK07564 634500004851 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 634500004852 active site 634500004853 substrate binding site [chemical binding]; other site 634500004854 metal binding site [ion binding]; metal-binding site 634500004855 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 634500004856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500004857 active site 634500004858 phosphorylation site [posttranslational modification] 634500004859 intermolecular recognition site; other site 634500004860 dimerization interface [polypeptide binding]; other site 634500004861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500004862 DNA binding site [nucleotide binding] 634500004863 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 634500004864 Protein of unknown function (DUF523); Region: DUF523; pfam04463 634500004865 Uncharacterized conserved protein [Function unknown]; Region: COG3272 634500004866 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 634500004867 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 634500004868 DNA photolyase; Region: DNA_photolyase; pfam00875 634500004869 oxidoreductase; Provisional; Region: PRK06128 634500004870 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 634500004871 NAD binding site [chemical binding]; other site 634500004872 metal binding site [ion binding]; metal-binding site 634500004873 active site 634500004874 Uncharacterized conserved protein [Function unknown]; Region: COG0327 634500004875 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 634500004876 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 634500004877 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 634500004878 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 634500004879 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 634500004880 putative active site [active] 634500004881 Predicted membrane protein [Function unknown]; Region: COG3819 634500004882 Predicted membrane protein [Function unknown]; Region: COG3817 634500004883 Protein of unknown function (DUF979); Region: DUF979; pfam06166 634500004884 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 634500004885 putative substrate binding pocket [chemical binding]; other site 634500004886 AC domain interface; other site 634500004887 catalytic triad [active] 634500004888 AB domain interface; other site 634500004889 interchain disulfide; other site 634500004890 endonuclease VIII; Provisional; Region: PRK10445 634500004891 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 634500004892 DNA binding site [nucleotide binding] 634500004893 putative catalytic residues [active] 634500004894 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 634500004895 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 634500004896 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 634500004897 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 634500004898 dimer interface [polypeptide binding]; other site 634500004899 active site 634500004900 citrylCoA binding site [chemical binding]; other site 634500004901 NADH binding [chemical binding]; other site 634500004902 cationic pore residues; other site 634500004903 oxalacetate/citrate binding site [chemical binding]; other site 634500004904 coenzyme A binding site [chemical binding]; other site 634500004905 catalytic triad [active] 634500004906 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 634500004907 Iron-sulfur protein interface; other site 634500004908 proximal quinone binding site [chemical binding]; other site 634500004909 SdhD (CybS) interface [polypeptide binding]; other site 634500004910 proximal heme binding site [chemical binding]; other site 634500004911 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 634500004912 SdhC subunit interface [polypeptide binding]; other site 634500004913 proximal heme binding site [chemical binding]; other site 634500004914 cardiolipin binding site; other site 634500004915 Iron-sulfur protein interface; other site 634500004916 proximal quinone binding site [chemical binding]; other site 634500004917 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 634500004918 L-aspartate oxidase; Provisional; Region: PRK06175 634500004919 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 634500004920 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 634500004921 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 634500004922 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 634500004923 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 634500004924 TPP-binding site [chemical binding]; other site 634500004925 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 634500004926 dimer interface [polypeptide binding]; other site 634500004927 PYR/PP interface [polypeptide binding]; other site 634500004928 TPP binding site [chemical binding]; other site 634500004929 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 634500004930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 634500004931 E3 interaction surface; other site 634500004932 lipoyl attachment site [posttranslational modification]; other site 634500004933 e3 binding domain; Region: E3_binding; pfam02817 634500004934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 634500004935 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 634500004936 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 634500004937 CoA-ligase; Region: Ligase_CoA; pfam00549 634500004938 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 634500004939 CoA binding domain; Region: CoA_binding; pfam02629 634500004940 CoA-ligase; Region: Ligase_CoA; pfam00549 634500004941 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 634500004942 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 634500004943 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 634500004944 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 634500004945 hypothetical protein; Provisional; Region: PRK10588 634500004946 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634500004947 active site 634500004948 colicin uptake protein TolQ; Provisional; Region: PRK10801 634500004949 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 634500004950 colicin uptake protein TolR; Provisional; Region: PRK11024 634500004951 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 634500004952 TolA C-terminal; Region: TolA; pfam06519 634500004953 translocation protein TolB; Provisional; Region: tolB; PRK03629 634500004954 TolB amino-terminal domain; Region: TolB_N; pfam04052 634500004955 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 634500004956 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 634500004957 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 634500004958 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 634500004959 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500004960 ligand binding site [chemical binding]; other site 634500004961 tol-pal system protein YbgF; Provisional; Region: PRK10803 634500004962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500004963 TPR motif; other site 634500004964 binding surface 634500004965 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 634500004966 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 634500004967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500004968 AlkA N-terminal domain; Region: AlkA_N; pfam06029 634500004969 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 634500004970 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634500004971 minor groove reading motif; other site 634500004972 helix-hairpin-helix signature motif; other site 634500004973 substrate binding pocket [chemical binding]; other site 634500004974 active site 634500004975 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 634500004976 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 634500004977 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 634500004978 DNA binding site [nucleotide binding] 634500004979 active site 634500004980 quinolinate synthetase; Provisional; Region: PRK09375 634500004981 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 634500004982 zinc transporter ZitB; Provisional; Region: PRK03557 634500004983 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500004984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500004985 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500004986 substrate binding pocket [chemical binding]; other site 634500004987 membrane-bound complex binding site; other site 634500004988 hinge residues; other site 634500004989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634500004990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500004991 dimer interface [polypeptide binding]; other site 634500004992 phosphorylation site [posttranslational modification] 634500004993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500004994 ATP binding site [chemical binding]; other site 634500004995 Mg2+ binding site [ion binding]; other site 634500004996 G-X-G motif; other site 634500004997 Response regulator receiver domain; Region: Response_reg; pfam00072 634500004998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500004999 active site 634500005000 phosphorylation site [posttranslational modification] 634500005001 intermolecular recognition site; other site 634500005002 dimerization interface [polypeptide binding]; other site 634500005003 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 634500005004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500005005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500005006 active site 634500005007 phosphorylation site [posttranslational modification] 634500005008 intermolecular recognition site; other site 634500005009 dimerization interface [polypeptide binding]; other site 634500005010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500005011 DNA binding residues [nucleotide binding] 634500005012 dimerization interface [polypeptide binding]; other site 634500005013 YbgS-like protein; Region: YbgS; pfam13985 634500005014 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 634500005015 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 634500005016 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500005017 catalytic core [active] 634500005018 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500005019 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 634500005020 active site 634500005021 catalytic residues [active] 634500005022 galactokinase; Provisional; Region: PRK05101 634500005023 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 634500005024 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634500005025 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 634500005026 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 634500005027 dimer interface [polypeptide binding]; other site 634500005028 active site 634500005029 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 634500005030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005031 Walker A/P-loop; other site 634500005032 ATP binding site [chemical binding]; other site 634500005033 Q-loop/lid; other site 634500005034 ABC transporter signature motif; other site 634500005035 Walker B; other site 634500005036 D-loop; other site 634500005037 H-loop/switch region; other site 634500005038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005039 Walker A/P-loop; other site 634500005040 ATP binding site [chemical binding]; other site 634500005041 Q-loop/lid; other site 634500005042 ABC transporter signature motif; other site 634500005043 Walker B; other site 634500005044 D-loop; other site 634500005045 H-loop/switch region; other site 634500005046 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 634500005047 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 634500005048 molybdenum-pterin binding domain; Region: Mop; TIGR00638 634500005049 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 634500005050 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 634500005051 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 634500005052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500005053 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500005054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005055 dimer interface [polypeptide binding]; other site 634500005056 conserved gate region; other site 634500005057 putative PBP binding loops; other site 634500005058 ABC-ATPase subunit interface; other site 634500005059 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 634500005060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005061 Walker A/P-loop; other site 634500005062 ATP binding site [chemical binding]; other site 634500005063 Q-loop/lid; other site 634500005064 ABC transporter signature motif; other site 634500005065 Walker B; other site 634500005066 D-loop; other site 634500005067 H-loop/switch region; other site 634500005068 TOBE domain; Region: TOBE; cl01440 634500005069 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 634500005070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500005071 active site 634500005072 motif I; other site 634500005073 motif II; other site 634500005074 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634500005075 6-phosphogluconolactonase; Provisional; Region: PRK11028 634500005076 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 634500005077 substrate binding site [chemical binding]; other site 634500005078 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 634500005079 intracellular protease, PfpI family; Region: PfpI; TIGR01382 634500005080 potential catalytic triad [active] 634500005081 conserved cys residue [active] 634500005082 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 634500005083 Prostaglandin dehydrogenases; Region: PGDH; cd05288 634500005084 NAD(P) binding site [chemical binding]; other site 634500005085 substrate binding site [chemical binding]; other site 634500005086 dimer interface [polypeptide binding]; other site 634500005087 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 634500005088 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500005089 inhibitor-cofactor binding pocket; inhibition site 634500005090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500005091 catalytic residue [active] 634500005092 biotin synthase; Provisional; Region: PRK15108 634500005093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500005094 FeS/SAM binding site; other site 634500005095 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 634500005096 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 634500005097 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 634500005098 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500005099 catalytic residue [active] 634500005100 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 634500005101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005102 S-adenosylmethionine binding site [chemical binding]; other site 634500005103 AAA domain; Region: AAA_26; pfam13500 634500005104 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 634500005105 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 634500005106 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634500005107 Walker A/P-loop; other site 634500005108 ATP binding site [chemical binding]; other site 634500005109 Q-loop/lid; other site 634500005110 ABC transporter signature motif; other site 634500005111 Walker B; other site 634500005112 D-loop; other site 634500005113 H-loop/switch region; other site 634500005114 excinuclease ABC subunit B; Provisional; Region: PRK05298 634500005115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500005116 ATP binding site [chemical binding]; other site 634500005117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500005118 nucleotide binding region [chemical binding]; other site 634500005119 ATP-binding site [chemical binding]; other site 634500005120 Ultra-violet resistance protein B; Region: UvrB; pfam12344 634500005121 UvrB/uvrC motif; Region: UVR; pfam02151 634500005122 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 634500005123 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 634500005124 phosphate binding site [ion binding]; other site 634500005125 putative substrate binding pocket [chemical binding]; other site 634500005126 dimer interface [polypeptide binding]; other site 634500005127 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 634500005128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500005129 FeS/SAM binding site; other site 634500005130 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 634500005131 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 634500005132 MPT binding site; other site 634500005133 trimer interface [polypeptide binding]; other site 634500005134 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 634500005135 trimer interface [polypeptide binding]; other site 634500005136 dimer interface [polypeptide binding]; other site 634500005137 putative active site [active] 634500005138 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 634500005139 MoaE interaction surface [polypeptide binding]; other site 634500005140 MoeB interaction surface [polypeptide binding]; other site 634500005141 thiocarboxylated glycine; other site 634500005142 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 634500005143 MoaE homodimer interface [polypeptide binding]; other site 634500005144 MoaD interaction [polypeptide binding]; other site 634500005145 active site residues [active] 634500005146 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 634500005147 Cache domain; Region: Cache_1; pfam02743 634500005148 HAMP domain; Region: HAMP; pfam00672 634500005149 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500005150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500005151 dimer interface [polypeptide binding]; other site 634500005152 putative CheW interface [polypeptide binding]; other site 634500005153 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 634500005154 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 634500005155 Predicted integral membrane protein [Function unknown]; Region: COG0392 634500005156 cardiolipin synthase 2; Provisional; Region: PRK11263 634500005157 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 634500005158 putative active site [active] 634500005159 catalytic site [active] 634500005160 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 634500005161 putative active site [active] 634500005162 catalytic site [active] 634500005163 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 634500005164 putative catalytic site [active] 634500005165 putative metal binding site [ion binding]; other site 634500005166 putative phosphate binding site [ion binding]; other site 634500005167 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 634500005168 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 634500005169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500005170 TPR motif; other site 634500005171 Tetratricopeptide repeat; Region: TPR_16; pfam13432 634500005172 binding surface 634500005173 RNA polymerase sigma factor; Provisional; Region: PRK12547 634500005174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500005175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500005176 DNA binding residues [nucleotide binding] 634500005177 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 634500005178 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 634500005179 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634500005180 ATP binding site [chemical binding]; other site 634500005181 Mg++ binding site [ion binding]; other site 634500005182 motif III; other site 634500005183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500005184 nucleotide binding region [chemical binding]; other site 634500005185 ATP-binding site [chemical binding]; other site 634500005186 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 634500005187 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 634500005188 FMN binding site [chemical binding]; other site 634500005189 active site 634500005190 catalytic residues [active] 634500005191 substrate binding site [chemical binding]; other site 634500005192 major facilitator superfamily transporter; Provisional; Region: PRK05122 634500005193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005194 putative substrate translocation pore; other site 634500005195 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 634500005196 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 634500005197 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 634500005198 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 634500005199 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 634500005200 Cl binding site [ion binding]; other site 634500005201 oligomer interface [polypeptide binding]; other site 634500005202 Protein of unknown function, DUF481; Region: DUF481; pfam04338 634500005203 L,D-transpeptidase; Provisional; Region: PRK10260 634500005204 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 634500005205 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634500005206 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 634500005207 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 634500005208 oxidoreductase; Provisional; Region: PRK12743 634500005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500005210 NAD(P) binding site [chemical binding]; other site 634500005211 active site 634500005212 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634500005213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 634500005214 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 634500005215 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 634500005216 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 634500005217 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 634500005218 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 634500005219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500005220 D-lactate dehydrogenase; Provisional; Region: PRK11183 634500005221 FAD binding domain; Region: FAD_binding_4; pfam01565 634500005222 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 634500005223 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 634500005224 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 634500005225 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 634500005226 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 634500005227 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 634500005228 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 634500005229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500005230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500005231 dimer interface [polypeptide binding]; other site 634500005232 putative CheW interface [polypeptide binding]; other site 634500005233 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 634500005234 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 634500005235 active site 634500005236 metal binding site [ion binding]; metal-binding site 634500005237 nudix motif; other site 634500005238 benzoate transport; Region: 2A0115; TIGR00895 634500005239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005240 putative substrate translocation pore; other site 634500005241 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 634500005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005243 dimer interface [polypeptide binding]; other site 634500005244 conserved gate region; other site 634500005245 ABC-ATPase subunit interface; other site 634500005246 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 634500005247 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 634500005248 Walker A/P-loop; other site 634500005249 ATP binding site [chemical binding]; other site 634500005250 Q-loop/lid; other site 634500005251 ABC transporter signature motif; other site 634500005252 Walker B; other site 634500005253 D-loop; other site 634500005254 H-loop/switch region; other site 634500005255 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 634500005256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005257 dimer interface [polypeptide binding]; other site 634500005258 conserved gate region; other site 634500005259 putative PBP binding loops; other site 634500005260 ABC-ATPase subunit interface; other site 634500005261 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 634500005262 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 634500005263 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 634500005264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005265 S-adenosylmethionine binding site [chemical binding]; other site 634500005266 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 634500005267 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 634500005268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634500005269 short chain dehydrogenase; Provisional; Region: PRK06101 634500005270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500005271 NAD(P) binding site [chemical binding]; other site 634500005272 active site 634500005273 SnoaL-like domain; Region: SnoaL_2; pfam12680 634500005274 transcriptional regulator MirA; Provisional; Region: PRK15043 634500005275 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 634500005276 DNA binding residues [nucleotide binding] 634500005277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500005278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500005279 sequence-specific DNA binding site [nucleotide binding]; other site 634500005280 salt bridge; other site 634500005281 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634500005282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500005283 Coenzyme A binding pocket [chemical binding]; other site 634500005284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500005285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500005286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500005287 dimerization interface [polypeptide binding]; other site 634500005288 argininosuccinate lyase; Provisional; Region: PRK00855 634500005289 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 634500005290 active sites [active] 634500005291 tetramer interface [polypeptide binding]; other site 634500005292 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005294 dimer interface [polypeptide binding]; other site 634500005295 conserved gate region; other site 634500005296 putative PBP binding loops; other site 634500005297 ABC-ATPase subunit interface; other site 634500005298 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500005299 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500005300 Walker A/P-loop; other site 634500005301 ATP binding site [chemical binding]; other site 634500005302 Q-loop/lid; other site 634500005303 ABC transporter signature motif; other site 634500005304 Walker B; other site 634500005305 D-loop; other site 634500005306 H-loop/switch region; other site 634500005307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500005308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005309 substrate binding pocket [chemical binding]; other site 634500005310 membrane-bound complex binding site; other site 634500005311 hinge residues; other site 634500005312 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 634500005313 active site 634500005314 catalytic site [active] 634500005315 Zn binding site [ion binding]; other site 634500005316 tetramer interface [polypeptide binding]; other site 634500005317 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 634500005318 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 634500005319 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 634500005320 active site 634500005321 catalytic site [active] 634500005322 Zn binding site [ion binding]; other site 634500005323 tetramer interface [polypeptide binding]; other site 634500005324 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 634500005325 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 634500005326 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634500005327 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 634500005328 active site 634500005329 NAD binding site [chemical binding]; other site 634500005330 metal binding site [ion binding]; metal-binding site 634500005331 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 634500005332 agmatinase; Region: agmatinase; TIGR01230 634500005333 oligomer interface [polypeptide binding]; other site 634500005334 putative active site [active] 634500005335 Mn binding site [ion binding]; other site 634500005336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500005337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500005338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500005339 dimerization interface [polypeptide binding]; other site 634500005340 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 634500005341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 634500005342 DEAD_2; Region: DEAD_2; pfam06733 634500005343 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 634500005344 glycosyl transferase family protein; Provisional; Region: PRK08136 634500005345 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 634500005346 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500005347 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 634500005348 metal binding site [ion binding]; metal-binding site 634500005349 putative dimer interface [polypeptide binding]; other site 634500005350 urocanate hydratase; Provisional; Region: PRK05414 634500005351 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 634500005352 active sites [active] 634500005353 tetramer interface [polypeptide binding]; other site 634500005354 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 634500005355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500005356 DNA-binding site [nucleotide binding]; DNA binding site 634500005357 UTRA domain; Region: UTRA; pfam07702 634500005358 HutD; Region: HutD; cl01532 634500005359 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 634500005360 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 634500005361 active site 634500005362 imidazolonepropionase; Validated; Region: PRK09356 634500005363 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 634500005364 active site 634500005365 N-formylglutamate amidohydrolase; Region: FGase; cl01522 634500005366 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 634500005367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500005368 DNA-binding site [nucleotide binding]; DNA binding site 634500005369 UTRA domain; Region: UTRA; pfam07702 634500005370 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 634500005371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005372 substrate binding pocket [chemical binding]; other site 634500005373 membrane-bound complex binding site; other site 634500005374 hinge residues; other site 634500005375 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005377 dimer interface [polypeptide binding]; other site 634500005378 conserved gate region; other site 634500005379 putative PBP binding loops; other site 634500005380 ABC-ATPase subunit interface; other site 634500005381 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005383 dimer interface [polypeptide binding]; other site 634500005384 conserved gate region; other site 634500005385 putative PBP binding loops; other site 634500005386 ABC-ATPase subunit interface; other site 634500005387 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 634500005388 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500005389 Walker A/P-loop; other site 634500005390 ATP binding site [chemical binding]; other site 634500005391 Q-loop/lid; other site 634500005392 ABC transporter signature motif; other site 634500005393 Walker B; other site 634500005394 D-loop; other site 634500005395 H-loop/switch region; other site 634500005396 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 634500005397 active sites [active] 634500005398 tetramer interface [polypeptide binding]; other site 634500005399 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 634500005400 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 634500005401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005402 S-adenosylmethionine binding site [chemical binding]; other site 634500005403 putative mechanosensitive channel protein; Provisional; Region: PRK11465 634500005404 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500005405 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 634500005406 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500005407 Walker A/P-loop; other site 634500005408 ATP binding site [chemical binding]; other site 634500005409 Q-loop/lid; other site 634500005410 ABC transporter signature motif; other site 634500005411 Walker B; other site 634500005412 D-loop; other site 634500005413 H-loop/switch region; other site 634500005414 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005416 dimer interface [polypeptide binding]; other site 634500005417 conserved gate region; other site 634500005418 putative PBP binding loops; other site 634500005419 ABC-ATPase subunit interface; other site 634500005420 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 634500005421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005422 substrate binding pocket [chemical binding]; other site 634500005423 membrane-bound complex binding site; other site 634500005424 hinge residues; other site 634500005425 hypothetical protein; Provisional; Region: PRK11019 634500005426 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 634500005427 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 634500005428 dimerization interface [polypeptide binding]; other site 634500005429 DPS ferroxidase diiron center [ion binding]; other site 634500005430 ion pore; other site 634500005431 threonine and homoserine efflux system; Provisional; Region: PRK10532 634500005432 EamA-like transporter family; Region: EamA; pfam00892 634500005433 outer membrane protein X; Provisional; Region: ompX; PRK09408 634500005434 manganese transport regulator MntR; Provisional; Region: PRK11050 634500005435 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 634500005436 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 634500005437 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 634500005438 transmembrane helices; other site 634500005439 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 634500005440 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 634500005441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500005442 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500005443 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634500005444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005445 putative substrate translocation pore; other site 634500005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005447 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 634500005448 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 634500005449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005451 Walker A/P-loop; other site 634500005452 ATP binding site [chemical binding]; other site 634500005453 ABC transporter signature motif; other site 634500005454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005455 Walker B; other site 634500005456 ABC transporter; Region: ABC_tran_2; pfam12848 634500005457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005458 Cache domain; Region: Cache_1; pfam02743 634500005459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500005460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500005461 metal binding site [ion binding]; metal-binding site 634500005462 active site 634500005463 I-site; other site 634500005464 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 634500005465 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 634500005466 ATP binding site [chemical binding]; other site 634500005467 substrate interface [chemical binding]; other site 634500005468 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 634500005469 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 634500005470 dimer interface [polypeptide binding]; other site 634500005471 putative functional site; other site 634500005472 putative MPT binding site; other site 634500005473 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 634500005474 catalytic nucleophile [active] 634500005475 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 634500005476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500005477 Walker A/P-loop; other site 634500005478 ATP binding site [chemical binding]; other site 634500005479 Q-loop/lid; other site 634500005480 ABC transporter signature motif; other site 634500005481 Walker B; other site 634500005482 D-loop; other site 634500005483 H-loop/switch region; other site 634500005484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500005485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500005486 Walker A/P-loop; other site 634500005487 ATP binding site [chemical binding]; other site 634500005488 Q-loop/lid; other site 634500005489 ABC transporter signature motif; other site 634500005490 Walker B; other site 634500005491 D-loop; other site 634500005492 H-loop/switch region; other site 634500005493 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500005494 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 634500005495 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 634500005496 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 634500005497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005498 dimer interface [polypeptide binding]; other site 634500005499 conserved gate region; other site 634500005500 putative PBP binding loops; other site 634500005501 ABC-ATPase subunit interface; other site 634500005502 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 634500005503 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634500005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005505 dimer interface [polypeptide binding]; other site 634500005506 conserved gate region; other site 634500005507 putative PBP binding loops; other site 634500005508 ABC-ATPase subunit interface; other site 634500005509 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 634500005510 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 634500005511 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 634500005512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500005513 FeS/SAM binding site; other site 634500005514 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 634500005515 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 634500005516 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 634500005517 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 634500005518 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 634500005519 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 634500005520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500005521 motif I; other site 634500005522 motif II; other site 634500005523 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 634500005524 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634500005525 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 634500005526 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 634500005527 serine transporter; Region: stp; TIGR00814 634500005528 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 634500005529 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 634500005530 active site 634500005531 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 634500005532 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 634500005533 GSH binding site [chemical binding]; other site 634500005534 catalytic residues [active] 634500005535 hypothetical protein; Provisional; Region: PRK10591 634500005536 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 634500005537 dimer interface [polypeptide binding]; other site 634500005538 FMN binding site [chemical binding]; other site 634500005539 NADPH bind site [chemical binding]; other site 634500005540 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 634500005541 RimK-like ATP-grasp domain; Region: RimK; pfam08443 634500005542 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 634500005543 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 634500005544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500005545 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 634500005546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005547 Walker A/P-loop; other site 634500005548 ATP binding site [chemical binding]; other site 634500005549 Q-loop/lid; other site 634500005550 ABC transporter signature motif; other site 634500005551 Walker B; other site 634500005552 D-loop; other site 634500005553 H-loop/switch region; other site 634500005554 TOBE domain; Region: TOBE_2; pfam08402 634500005555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005556 dimer interface [polypeptide binding]; other site 634500005557 conserved gate region; other site 634500005558 putative PBP binding loops; other site 634500005559 ABC-ATPase subunit interface; other site 634500005560 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500005561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005562 dimer interface [polypeptide binding]; other site 634500005563 conserved gate region; other site 634500005564 putative PBP binding loops; other site 634500005565 ABC-ATPase subunit interface; other site 634500005566 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 634500005567 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500005568 metal binding site [ion binding]; metal-binding site 634500005569 putative dimer interface [polypeptide binding]; other site 634500005570 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 634500005571 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 634500005572 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 634500005573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005574 substrate binding pocket [chemical binding]; other site 634500005575 membrane-bound complex binding site; other site 634500005576 hinge residues; other site 634500005577 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005579 dimer interface [polypeptide binding]; other site 634500005580 conserved gate region; other site 634500005581 putative PBP binding loops; other site 634500005582 ABC-ATPase subunit interface; other site 634500005583 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500005584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005585 dimer interface [polypeptide binding]; other site 634500005586 conserved gate region; other site 634500005587 putative PBP binding loops; other site 634500005588 ABC-ATPase subunit interface; other site 634500005589 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 634500005590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005591 substrate binding pocket [chemical binding]; other site 634500005592 membrane-bound complex binding site; other site 634500005593 hinge residues; other site 634500005594 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 634500005595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005596 Walker A/P-loop; other site 634500005597 ATP binding site [chemical binding]; other site 634500005598 Q-loop/lid; other site 634500005599 ABC transporter signature motif; other site 634500005600 Walker B; other site 634500005601 D-loop; other site 634500005602 H-loop/switch region; other site 634500005603 putative lipoprotein; Provisional; Region: PRK10533 634500005604 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 634500005605 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 634500005606 amidase catalytic site [active] 634500005607 Zn binding residues [ion binding]; other site 634500005608 substrate binding site [chemical binding]; other site 634500005609 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 634500005610 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 634500005611 tetramer interface [polypeptide binding]; other site 634500005612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500005613 catalytic residue [active] 634500005614 pyruvate dehydrogenase; Provisional; Region: PRK09124 634500005615 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 634500005616 PYR/PP interface [polypeptide binding]; other site 634500005617 dimer interface [polypeptide binding]; other site 634500005618 tetramer interface [polypeptide binding]; other site 634500005619 TPP binding site [chemical binding]; other site 634500005620 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500005621 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 634500005622 TPP-binding site [chemical binding]; other site 634500005623 Predicted membrane protein [Function unknown]; Region: COG2431 634500005624 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500005625 DNA-binding site [nucleotide binding]; DNA binding site 634500005626 RNA-binding motif; other site 634500005627 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 634500005628 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 634500005629 Clp amino terminal domain; Region: Clp_N; pfam02861 634500005630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500005631 Walker A motif; other site 634500005632 ATP binding site [chemical binding]; other site 634500005633 Walker B motif; other site 634500005634 arginine finger; other site 634500005635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500005636 Walker A motif; other site 634500005637 ATP binding site [chemical binding]; other site 634500005638 Walker B motif; other site 634500005639 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 634500005640 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 634500005641 rRNA binding site [nucleotide binding]; other site 634500005642 predicted 30S ribosome binding site; other site 634500005643 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 634500005644 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 634500005645 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500005646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005647 Walker A/P-loop; other site 634500005648 ATP binding site [chemical binding]; other site 634500005649 Q-loop/lid; other site 634500005650 Walker B; other site 634500005651 D-loop; other site 634500005652 H-loop/switch region; other site 634500005653 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 634500005654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500005655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005656 Walker A/P-loop; other site 634500005657 ATP binding site [chemical binding]; other site 634500005658 Q-loop/lid; other site 634500005659 ABC transporter signature motif; other site 634500005660 Walker B; other site 634500005661 D-loop; other site 634500005662 H-loop/switch region; other site 634500005663 thioredoxin reductase; Provisional; Region: PRK10262 634500005664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500005665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500005666 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 634500005667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500005668 putative DNA binding site [nucleotide binding]; other site 634500005669 putative Zn2+ binding site [ion binding]; other site 634500005670 AsnC family; Region: AsnC_trans_reg; pfam01037 634500005671 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 634500005672 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 634500005673 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 634500005674 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 634500005675 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 634500005676 recombination factor protein RarA; Reviewed; Region: PRK13342 634500005677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500005678 Walker A motif; other site 634500005679 ATP binding site [chemical binding]; other site 634500005680 Walker B motif; other site 634500005681 arginine finger; other site 634500005682 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 634500005683 seryl-tRNA synthetase; Provisional; Region: PRK05431 634500005684 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 634500005685 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 634500005686 dimer interface [polypeptide binding]; other site 634500005687 active site 634500005688 motif 1; other site 634500005689 motif 2; other site 634500005690 motif 3; other site 634500005691 putative MFS family transporter protein; Provisional; Region: PRK03633 634500005692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005693 putative substrate translocation pore; other site 634500005694 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 634500005695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500005696 FeS/SAM binding site; other site 634500005697 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 634500005698 Pyruvate formate lyase 1; Region: PFL1; cd01678 634500005699 coenzyme A binding site [chemical binding]; other site 634500005700 active site 634500005701 catalytic residues [active] 634500005702 glycine loop; other site 634500005703 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 634500005704 uncharacterized domain; Region: TIGR00702 634500005705 YcaO-like family; Region: YcaO; pfam02624 634500005706 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 634500005707 homodimer interface [polypeptide binding]; other site 634500005708 substrate-cofactor binding pocket; other site 634500005709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500005710 catalytic residue [active] 634500005711 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 634500005712 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 634500005713 hinge; other site 634500005714 active site 634500005715 cytidylate kinase; Provisional; Region: cmk; PRK00023 634500005716 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 634500005717 CMP-binding site; other site 634500005718 The sites determining sugar specificity; other site 634500005719 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 634500005720 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 634500005721 RNA binding site [nucleotide binding]; other site 634500005722 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 634500005723 RNA binding site [nucleotide binding]; other site 634500005724 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 634500005725 RNA binding site [nucleotide binding]; other site 634500005726 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 634500005727 RNA binding site [nucleotide binding]; other site 634500005728 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 634500005729 RNA binding site [nucleotide binding]; other site 634500005730 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 634500005731 RNA binding site [nucleotide binding]; other site 634500005732 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 634500005733 IHF dimer interface [polypeptide binding]; other site 634500005734 IHF - DNA interface [nucleotide binding]; other site 634500005735 ComEC family competence protein; Provisional; Region: PRK11539 634500005736 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 634500005737 Competence protein; Region: Competence; pfam03772 634500005738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 634500005739 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 634500005740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500005741 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 634500005742 Walker A/P-loop; other site 634500005743 ATP binding site [chemical binding]; other site 634500005744 Q-loop/lid; other site 634500005745 ABC transporter signature motif; other site 634500005746 Walker B; other site 634500005747 D-loop; other site 634500005748 H-loop/switch region; other site 634500005749 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 634500005750 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 634500005751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 634500005752 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 634500005753 Trm112p-like protein; Region: Trm112p; cl01066 634500005754 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 634500005755 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 634500005756 Ligand binding site; other site 634500005757 oligomer interface; other site 634500005758 hypothetical protein; Provisional; Region: PRK10593 634500005759 Uncharacterized conserved protein [Function unknown]; Region: COG1434 634500005760 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 634500005761 putative active site [active] 634500005762 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634500005763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005764 S-adenosylmethionine binding site [chemical binding]; other site 634500005765 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 634500005766 condesin subunit F; Provisional; Region: PRK05260 634500005767 condesin subunit E; Provisional; Region: PRK05256 634500005768 cell division protein MukB; Provisional; Region: mukB; PRK04863 634500005769 MukB N-terminal; Region: MukB; pfam04310 634500005770 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 634500005771 murein L,D-transpeptidase; Provisional; Region: PRK10594 634500005772 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 634500005773 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634500005774 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634500005775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 634500005776 Peptidase M15; Region: Peptidase_M15_3; cl01194 634500005777 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 634500005778 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 634500005779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500005780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500005781 homodimer interface [polypeptide binding]; other site 634500005782 catalytic residue [active] 634500005783 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500005784 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500005785 trimer interface [polypeptide binding]; other site 634500005786 eyelet of channel; other site 634500005787 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 634500005788 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 634500005789 putative dimer interface [polypeptide binding]; other site 634500005790 putative anticodon binding site; other site 634500005791 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 634500005792 homodimer interface [polypeptide binding]; other site 634500005793 motif 1; other site 634500005794 motif 2; other site 634500005795 active site 634500005796 motif 3; other site 634500005797 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 634500005798 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 634500005799 active site 634500005800 aminopeptidase N; Provisional; Region: pepN; PRK14015 634500005801 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 634500005802 active site 634500005803 Zn binding site [ion binding]; other site 634500005804 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 634500005805 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634500005806 Walker A/P-loop; other site 634500005807 ATP binding site [chemical binding]; other site 634500005808 Q-loop/lid; other site 634500005809 ABC transporter signature motif; other site 634500005810 Walker B; other site 634500005811 D-loop; other site 634500005812 H-loop/switch region; other site 634500005813 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634500005814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500005815 dimer interface [polypeptide binding]; other site 634500005816 conserved gate region; other site 634500005817 putative PBP binding loops; other site 634500005818 ABC-ATPase subunit interface; other site 634500005819 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 634500005820 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500005821 active site 634500005822 dimer interface [polypeptide binding]; other site 634500005823 non-prolyl cis peptide bond; other site 634500005824 insertion regions; other site 634500005825 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500005826 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500005827 substrate binding pocket [chemical binding]; other site 634500005828 membrane-bound complex binding site; other site 634500005829 hinge residues; other site 634500005830 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 634500005831 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634500005832 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 634500005833 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 634500005834 quinone interaction residues [chemical binding]; other site 634500005835 active site 634500005836 catalytic residues [active] 634500005837 FMN binding site [chemical binding]; other site 634500005838 substrate binding site [chemical binding]; other site 634500005839 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 634500005840 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 634500005841 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 634500005842 MOSC domain; Region: MOSC; pfam03473 634500005843 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634500005844 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 634500005845 catalytic loop [active] 634500005846 iron binding site [ion binding]; other site 634500005847 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 634500005848 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 634500005849 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 634500005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005851 S-adenosylmethionine binding site [chemical binding]; other site 634500005852 ABC transporter ATPase component; Reviewed; Region: PRK11147 634500005853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500005855 Walker A/P-loop; other site 634500005856 ATP binding site [chemical binding]; other site 634500005857 Q-loop/lid; other site 634500005858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005859 ABC transporter signature motif; other site 634500005860 Walker B; other site 634500005861 D-loop; other site 634500005862 ABC transporter; Region: ABC_tran_2; pfam12848 634500005863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500005864 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 634500005865 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500005866 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500005867 paraquat-inducible protein B; Provisional; Region: PRK10807 634500005868 mce related protein; Region: MCE; pfam02470 634500005869 mce related protein; Region: MCE; pfam02470 634500005870 mce related protein; Region: MCE; pfam02470 634500005871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 634500005872 Protein of unknown function (DUF330); Region: DUF330; pfam03886 634500005873 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 634500005874 active site 1 [active] 634500005875 dimer interface [polypeptide binding]; other site 634500005876 active site 2 [active] 634500005877 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 634500005878 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 634500005879 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 634500005880 outer membrane protein A; Reviewed; Region: PRK10808 634500005881 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 634500005882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500005883 ligand binding site [chemical binding]; other site 634500005884 SOS cell division inhibitor; Provisional; Region: PRK10595 634500005885 TfoX N-terminal domain; Region: TfoX_N; pfam04993 634500005886 TfoX C-terminal domain; Region: TfoX_C; pfam04994 634500005887 TIGR01666 family membrane protein; Region: YCCS 634500005888 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 634500005889 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500005890 Predicted membrane protein [Function unknown]; Region: COG3304 634500005891 Domain of unknown function (DUF307); Region: DUF307; pfam03733 634500005892 Domain of unknown function (DUF307); Region: DUF307; pfam03733 634500005893 DNA helicase IV; Provisional; Region: helD; PRK11054 634500005894 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 634500005895 Part of AAA domain; Region: AAA_19; pfam13245 634500005896 Family description; Region: UvrD_C_2; pfam13538 634500005897 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 634500005898 active site 634500005899 dimer interfaces [polypeptide binding]; other site 634500005900 catalytic residues [active] 634500005901 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 634500005902 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 634500005903 heat shock protein HspQ; Provisional; Region: PRK14129 634500005904 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 634500005905 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 634500005906 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 634500005907 putative RNA binding site [nucleotide binding]; other site 634500005908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500005909 S-adenosylmethionine binding site [chemical binding]; other site 634500005910 acylphosphatase; Provisional; Region: PRK14426 634500005911 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 634500005912 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 634500005913 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 634500005914 YccA-like proteins; Region: YccA_like; cd10433 634500005915 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 634500005916 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 634500005917 catalytic core [active] 634500005918 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 634500005919 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 634500005920 NAD(P) binding site [chemical binding]; other site 634500005921 catalytic residues [active] 634500005922 hypothetical protein; Provisional; Region: PRK10174 634500005923 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 634500005924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634500005925 EamA-like transporter family; Region: EamA; pfam00892 634500005926 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634500005927 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 634500005928 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 634500005929 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 634500005930 putative FMN binding site [chemical binding]; other site 634500005931 pyrimidine utilization protein D; Region: RutD; TIGR03611 634500005932 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 634500005933 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500005934 homotrimer interaction site [polypeptide binding]; other site 634500005935 putative active site [active] 634500005936 Isochorismatase family; Region: Isochorismatase; pfam00857 634500005937 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 634500005938 catalytic triad [active] 634500005939 conserved cis-peptide bond; other site 634500005940 pyrimidine utilization protein A; Region: RutA; TIGR03612 634500005941 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500005942 active site 634500005943 dimer interface [polypeptide binding]; other site 634500005944 non-prolyl cis peptide bond; other site 634500005945 insertion regions; other site 634500005946 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 634500005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500005948 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 634500005949 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 634500005950 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 634500005951 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 634500005952 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 634500005953 Autoinducer binding domain; Region: Autoind_bind; pfam03472 634500005954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500005955 DNA binding residues [nucleotide binding] 634500005956 dimerization interface [polypeptide binding]; other site 634500005957 Autoinducer synthetase; Region: Autoind_synth; cl17404 634500005958 GlpM protein; Region: GlpM; pfam06942 634500005959 hypothetical protein; Provisional; Region: PRK10613 634500005960 response regulator; Provisional; Region: PRK09483 634500005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500005962 active site 634500005963 phosphorylation site [posttranslational modification] 634500005964 intermolecular recognition site; other site 634500005965 dimerization interface [polypeptide binding]; other site 634500005966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500005967 DNA binding residues [nucleotide binding] 634500005968 dimerization interface [polypeptide binding]; other site 634500005969 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 634500005970 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 634500005971 GIY-YIG motif/motif A; other site 634500005972 active site 634500005973 catalytic site [active] 634500005974 putative DNA binding site [nucleotide binding]; other site 634500005975 metal binding site [ion binding]; metal-binding site 634500005976 UvrB/uvrC motif; Region: UVR; pfam02151 634500005977 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 634500005978 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 634500005979 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 634500005980 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 634500005981 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500005982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500005983 Helix-turn-helix domain; Region: HTH_18; pfam12833 634500005984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500005985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634500005986 MarR family; Region: MarR; pfam01047 634500005987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500005988 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634500005989 putative substrate translocation pore; other site 634500005990 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 634500005991 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500005992 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500005993 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 634500005994 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 634500005995 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 634500005996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 634500005997 putative acyl-acceptor binding pocket; other site 634500005998 Phosphopantetheine attachment site; Region: PP-binding; cl09936 634500005999 acyl carrier protein; Provisional; Region: PRK05350 634500006000 Predicted membrane protein [Function unknown]; Region: COG4648 634500006001 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634500006002 AMP-binding enzyme; Region: AMP-binding; pfam00501 634500006003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634500006004 acyl-activating enzyme (AAE) consensus motif; other site 634500006005 acyl-activating enzyme (AAE) consensus motif; other site 634500006006 active site 634500006007 AMP binding site [chemical binding]; other site 634500006008 CoA binding site [chemical binding]; other site 634500006009 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 634500006010 active site 2 [active] 634500006011 dimer interface [polypeptide binding]; other site 634500006012 active site 1 [active] 634500006013 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500006014 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634500006015 Ligand binding site; other site 634500006016 Putative Catalytic site; other site 634500006017 DXD motif; other site 634500006018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 634500006019 putative acyl-acceptor binding pocket; other site 634500006020 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 634500006021 active site 634500006022 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 634500006023 Predicted exporter [General function prediction only]; Region: COG4258 634500006024 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 634500006025 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 634500006026 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634500006027 dimer interface [polypeptide binding]; other site 634500006028 active site 634500006029 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 634500006030 putative active site 1 [active] 634500006031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500006032 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 634500006033 NAD(P) binding site [chemical binding]; other site 634500006034 active site 634500006035 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 634500006036 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634500006037 dimer interface [polypeptide binding]; other site 634500006038 active site 634500006039 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 634500006040 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500006041 N-terminal plug; other site 634500006042 ligand-binding site [chemical binding]; other site 634500006043 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 634500006044 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 634500006045 PLD-like domain; Region: PLDc_2; pfam13091 634500006046 putative active site [active] 634500006047 catalytic site [active] 634500006048 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 634500006049 PLD-like domain; Region: PLDc_2; pfam13091 634500006050 putative active site [active] 634500006051 catalytic site [active] 634500006052 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 634500006053 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500006054 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 634500006055 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 634500006056 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 634500006057 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 634500006058 Ligand binding site; other site 634500006059 DXD motif; other site 634500006060 lipoprotein; Provisional; Region: PRK10175 634500006061 secY/secA suppressor protein; Provisional; Region: PRK11467 634500006062 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 634500006063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 634500006064 active site 634500006065 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 634500006066 drug efflux system protein MdtG; Provisional; Region: PRK09874 634500006067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500006068 putative substrate translocation pore; other site 634500006069 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 634500006070 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 634500006071 putative acyl-acceptor binding pocket; other site 634500006072 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500006073 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 634500006074 active site 634500006075 FMN binding site [chemical binding]; other site 634500006076 substrate binding site [chemical binding]; other site 634500006077 homotetramer interface [polypeptide binding]; other site 634500006078 catalytic residue [active] 634500006079 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 634500006080 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 634500006081 active site residue [active] 634500006082 hypothetical protein; Provisional; Region: PRK03757 634500006083 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 634500006084 proline/glycine betaine transporter; Provisional; Region: PRK10642 634500006085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500006086 putative substrate translocation pore; other site 634500006087 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 634500006088 hydroxyglutarate oxidase; Provisional; Region: PRK11728 634500006089 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 634500006090 DNA damage-inducible protein I; Provisional; Region: PRK10597 634500006091 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 634500006092 active site 634500006093 substrate binding pocket [chemical binding]; other site 634500006094 dimer interface [polypeptide binding]; other site 634500006095 lipoprotein; Provisional; Region: PRK10598 634500006096 glutaredoxin 2; Provisional; Region: PRK10387 634500006097 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 634500006098 C-terminal domain interface [polypeptide binding]; other site 634500006099 GSH binding site (G-site) [chemical binding]; other site 634500006100 catalytic residues [active] 634500006101 putative dimer interface [polypeptide binding]; other site 634500006102 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 634500006103 N-terminal domain interface [polypeptide binding]; other site 634500006104 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 634500006105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 634500006106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 634500006107 hypothetical protein; Provisional; Region: PRK11239 634500006108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500006109 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500006110 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 634500006111 MviN-like protein; Region: MVIN; pfam03023 634500006112 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 634500006113 FlgN protein; Region: FlgN; cl09176 634500006114 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 634500006115 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 634500006116 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 634500006117 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 634500006118 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 634500006119 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 634500006120 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634500006121 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634500006122 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 634500006123 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 634500006124 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 634500006125 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 634500006126 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634500006127 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 634500006128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 634500006129 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 634500006130 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634500006131 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634500006132 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 634500006133 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 634500006134 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634500006135 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 634500006136 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 634500006137 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 634500006138 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 634500006139 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 634500006140 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 634500006141 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 634500006142 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 634500006143 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 634500006144 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 634500006145 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 634500006146 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 634500006147 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 634500006148 homodimer interface [polypeptide binding]; other site 634500006149 oligonucleotide binding site [chemical binding]; other site 634500006150 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 634500006151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500006152 RNA binding surface [nucleotide binding]; other site 634500006153 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634500006154 active site 634500006155 Maf-like protein; Region: Maf; pfam02545 634500006156 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 634500006157 active site 634500006158 dimer interface [polypeptide binding]; other site 634500006159 hypothetical protein; Provisional; Region: PRK11193 634500006160 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 634500006161 putative phosphate acyltransferase; Provisional; Region: PRK05331 634500006162 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 634500006163 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 634500006164 dimer interface [polypeptide binding]; other site 634500006165 active site 634500006166 CoA binding pocket [chemical binding]; other site 634500006167 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 634500006168 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 634500006169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634500006170 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 634500006171 NAD(P) binding site [chemical binding]; other site 634500006172 homotetramer interface [polypeptide binding]; other site 634500006173 homodimer interface [polypeptide binding]; other site 634500006174 active site 634500006175 acyl carrier protein; Provisional; Region: acpP; PRK00982 634500006176 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 634500006177 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634500006178 dimer interface [polypeptide binding]; other site 634500006179 active site 634500006180 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 634500006181 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 634500006182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500006183 catalytic residue [active] 634500006184 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 634500006185 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 634500006186 dimerization interface [polypeptide binding]; other site 634500006187 thymidylate kinase; Validated; Region: tmk; PRK00698 634500006188 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 634500006189 TMP-binding site; other site 634500006190 ATP-binding site [chemical binding]; other site 634500006191 DNA polymerase III subunit delta'; Validated; Region: PRK07993 634500006192 DNA polymerase III subunit delta'; Validated; Region: PRK08485 634500006193 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 634500006194 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 634500006195 active site 634500006196 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 634500006197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500006198 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500006199 active site turn [active] 634500006200 phosphorylation site [posttranslational modification] 634500006201 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 634500006202 nucleotide binding site/active site [active] 634500006203 HIT family signature motif; other site 634500006204 catalytic residue [active] 634500006205 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 634500006206 putative dimer interface [polypeptide binding]; other site 634500006207 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 634500006208 thiamine kinase; Region: ycfN_thiK; TIGR02721 634500006209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 634500006210 active site 634500006211 ATP binding site [chemical binding]; other site 634500006212 substrate binding site [chemical binding]; other site 634500006213 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 634500006214 beta-hexosaminidase; Provisional; Region: PRK05337 634500006215 hypothetical protein; Provisional; Region: PRK04940 634500006216 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 634500006217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500006218 hypothetical protein; Provisional; Region: PRK11280 634500006219 transcription-repair coupling factor; Provisional; Region: PRK10689 634500006220 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 634500006221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500006222 ATP binding site [chemical binding]; other site 634500006223 putative Mg++ binding site [ion binding]; other site 634500006224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500006225 nucleotide binding region [chemical binding]; other site 634500006226 ATP-binding site [chemical binding]; other site 634500006227 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 634500006228 PapC C-terminal domain; Region: PapC_C; pfam13953 634500006229 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 634500006230 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 634500006231 FtsX-like permease family; Region: FtsX; pfam02687 634500006232 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 634500006233 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 634500006234 Walker A/P-loop; other site 634500006235 ATP binding site [chemical binding]; other site 634500006236 Q-loop/lid; other site 634500006237 ABC transporter signature motif; other site 634500006238 Walker B; other site 634500006239 D-loop; other site 634500006240 H-loop/switch region; other site 634500006241 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 634500006242 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 634500006243 FtsX-like permease family; Region: FtsX; pfam02687 634500006244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 634500006245 fructokinase; Reviewed; Region: PRK09557 634500006246 NAD-dependent deacetylase; Provisional; Region: PRK00481 634500006247 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 634500006248 NAD+ binding site [chemical binding]; other site 634500006249 substrate binding site [chemical binding]; other site 634500006250 Zn binding site [ion binding]; other site 634500006251 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500006252 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 634500006253 active site turn [active] 634500006254 phosphorylation site [posttranslational modification] 634500006255 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500006256 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 634500006257 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 634500006258 metal binding site [ion binding]; metal-binding site 634500006259 substrate binding pocket [chemical binding]; other site 634500006260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500006261 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 634500006262 DNA-binding site [nucleotide binding]; DNA binding site 634500006263 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 634500006264 Benzoate membrane transport protein; Region: BenE; pfam03594 634500006265 benzoate transporter; Region: benE; TIGR00843 634500006266 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 634500006267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500006268 non-specific DNA binding site [nucleotide binding]; other site 634500006269 salt bridge; other site 634500006270 sequence-specific DNA binding site [nucleotide binding]; other site 634500006271 Cupin domain; Region: Cupin_2; pfam07883 634500006272 peptidase T; Region: peptidase-T; TIGR01882 634500006273 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 634500006274 metal binding site [ion binding]; metal-binding site 634500006275 dimer interface [polypeptide binding]; other site 634500006276 Uncharacterized conserved protein [Function unknown]; Region: COG2850 634500006277 Cupin-like domain; Region: Cupin_8; pfam13621 634500006278 sensor protein PhoQ; Provisional; Region: PRK10815 634500006279 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 634500006280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500006281 dimer interface [polypeptide binding]; other site 634500006282 phosphorylation site [posttranslational modification] 634500006283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500006284 ATP binding site [chemical binding]; other site 634500006285 Mg2+ binding site [ion binding]; other site 634500006286 G-X-G motif; other site 634500006287 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 634500006288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006289 active site 634500006290 phosphorylation site [posttranslational modification] 634500006291 intermolecular recognition site; other site 634500006292 dimerization interface [polypeptide binding]; other site 634500006293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500006294 DNA binding site [nucleotide binding] 634500006295 adenylosuccinate lyase; Provisional; Region: PRK09285 634500006296 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 634500006297 tetramer interface [polypeptide binding]; other site 634500006298 active site 634500006299 putative lysogenization regulator; Reviewed; Region: PRK00218 634500006300 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 634500006301 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 634500006302 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 634500006303 nudix motif; other site 634500006304 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 634500006305 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 634500006306 active site 634500006307 isocitrate dehydrogenase; Validated; Region: PRK07362 634500006308 isocitrate dehydrogenase; Reviewed; Region: PRK07006 634500006309 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500006310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500006311 Coenzyme A binding pocket [chemical binding]; other site 634500006312 AAA domain; Region: AAA_33; pfam13671 634500006313 AAA domain; Region: AAA_17; pfam13207 634500006314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 634500006315 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500006316 Protein of unknown function (DUF754); Region: DUF754; pfam05449 634500006317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500006318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500006319 non-specific DNA binding site [nucleotide binding]; other site 634500006320 salt bridge; other site 634500006321 sequence-specific DNA binding site [nucleotide binding]; other site 634500006322 Predicted transcriptional regulator [Transcription]; Region: COG2932 634500006323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500006324 Catalytic site [active] 634500006325 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 634500006326 catalytic residue [active] 634500006327 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 634500006328 DinI-like family; Region: DinI; cl11630 634500006329 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 634500006330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634500006331 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 634500006332 dimer interface [polypeptide binding]; other site 634500006333 catalytic triad [active] 634500006334 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 634500006335 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500006336 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500006337 catalytic residue [active] 634500006338 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 634500006339 Flagellar regulator YcgR; Region: YcgR; pfam07317 634500006340 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 634500006341 PilZ domain; Region: PilZ; pfam07238 634500006342 hypothetical protein; Provisional; Region: PRK10457 634500006343 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 634500006344 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500006345 N-terminal plug; other site 634500006346 ligand-binding site [chemical binding]; other site 634500006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500006348 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500006349 putative substrate translocation pore; other site 634500006350 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 634500006351 Trehalase; Region: Trehalase; cl17346 634500006352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500006353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500006354 substrate binding pocket [chemical binding]; other site 634500006355 membrane-bound complex binding site; other site 634500006356 hinge residues; other site 634500006357 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 634500006358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634500006359 classical (c) SDRs; Region: SDR_c; cd05233 634500006360 NAD(P) binding site [chemical binding]; other site 634500006361 active site 634500006362 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500006363 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500006364 Walker A/P-loop; other site 634500006365 ATP binding site [chemical binding]; other site 634500006366 Q-loop/lid; other site 634500006367 ABC transporter signature motif; other site 634500006368 Walker B; other site 634500006369 D-loop; other site 634500006370 H-loop/switch region; other site 634500006371 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500006372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500006373 dimer interface [polypeptide binding]; other site 634500006374 conserved gate region; other site 634500006375 ABC-ATPase subunit interface; other site 634500006376 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634500006377 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 634500006378 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 634500006379 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 634500006380 [2Fe-2S] cluster binding site [ion binding]; other site 634500006381 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 634500006382 hydrophobic ligand binding site; other site 634500006383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500006384 active site 634500006385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500006386 catalytic tetrad [active] 634500006387 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 634500006388 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 634500006389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500006390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500006391 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 634500006392 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 634500006393 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 634500006394 acyl-CoA synthetase; Provisional; Region: PTZ00342 634500006395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500006396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500006397 DNA binding site [nucleotide binding] 634500006398 domain linker motif; other site 634500006399 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 634500006400 dimerization interface (closed form) [polypeptide binding]; other site 634500006401 ligand binding site [chemical binding]; other site 634500006402 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 634500006403 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500006404 active site turn [active] 634500006405 phosphorylation site [posttranslational modification] 634500006406 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 634500006407 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 634500006408 beta-galactosidase; Region: BGL; TIGR03356 634500006409 fumarate hydratase; Provisional; Region: PRK15389 634500006410 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 634500006411 Fumarase C-terminus; Region: Fumerase_C; pfam05683 634500006412 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 634500006413 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 634500006414 transmembrane helices; other site 634500006415 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500006416 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 634500006417 putative active site [active] 634500006418 putative FMN binding site [chemical binding]; other site 634500006419 putative substrate binding site [chemical binding]; other site 634500006420 putative catalytic residue [active] 634500006421 FMN-binding domain; Region: FMN_bind; cl01081 634500006422 L-aspartate oxidase; Provisional; Region: PRK06175 634500006423 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 634500006424 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500006425 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500006426 trimer interface [polypeptide binding]; other site 634500006427 eyelet of channel; other site 634500006428 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 634500006429 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 634500006430 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 634500006431 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 634500006432 active site 634500006433 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500006435 dimer interface [polypeptide binding]; other site 634500006436 conserved gate region; other site 634500006437 putative PBP binding loops; other site 634500006438 ABC-ATPase subunit interface; other site 634500006439 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 634500006440 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500006441 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634500006442 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500006443 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500006444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500006445 Walker A/P-loop; other site 634500006446 ATP binding site [chemical binding]; other site 634500006447 Q-loop/lid; other site 634500006448 ABC transporter signature motif; other site 634500006449 Walker B; other site 634500006450 D-loop; other site 634500006451 H-loop/switch region; other site 634500006452 TOBE domain; Region: TOBE_2; pfam08402 634500006453 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 634500006454 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500006455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500006456 DNA-binding site [nucleotide binding]; DNA binding site 634500006457 FCD domain; Region: FCD; pfam07729 634500006458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500006459 Coenzyme A binding pocket [chemical binding]; other site 634500006460 EamA-like transporter family; Region: EamA; pfam00892 634500006461 EamA-like transporter family; Region: EamA; pfam00892 634500006462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500006463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500006464 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634500006465 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 634500006466 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500006467 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500006468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634500006469 HAMP domain; Region: HAMP; pfam00672 634500006470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500006471 dimer interface [polypeptide binding]; other site 634500006472 phosphorylation site [posttranslational modification] 634500006473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500006474 ATP binding site [chemical binding]; other site 634500006475 Mg2+ binding site [ion binding]; other site 634500006476 G-X-G motif; other site 634500006477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634500006478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006479 active site 634500006480 phosphorylation site [posttranslational modification] 634500006481 intermolecular recognition site; other site 634500006482 dimerization interface [polypeptide binding]; other site 634500006483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500006484 DNA binding site [nucleotide binding] 634500006485 MltA-interacting protein MipA; Region: MipA; cl01504 634500006486 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 634500006487 ApbE family; Region: ApbE; pfam02424 634500006488 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 634500006489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006490 active site 634500006491 phosphorylation site [posttranslational modification] 634500006492 intermolecular recognition site; other site 634500006493 dimerization interface [polypeptide binding]; other site 634500006494 sensory histidine kinase DcuS; Provisional; Region: PRK11086 634500006495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500006496 ATP binding site [chemical binding]; other site 634500006497 Mg2+ binding site [ion binding]; other site 634500006498 G-X-G motif; other site 634500006499 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 634500006500 putative active site [active] 634500006501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500006502 dimerization interface [polypeptide binding]; other site 634500006503 putative DNA binding site [nucleotide binding]; other site 634500006504 putative Zn2+ binding site [ion binding]; other site 634500006505 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500006506 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500006507 FMN binding site [chemical binding]; other site 634500006508 active site 634500006509 substrate binding site [chemical binding]; other site 634500006510 catalytic residue [active] 634500006511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500006512 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500006513 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500006514 dimer interface [polypeptide binding]; other site 634500006515 ligand binding site [chemical binding]; other site 634500006516 HAMP domain; Region: HAMP; pfam00672 634500006517 dimerization interface [polypeptide binding]; other site 634500006518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500006519 dimer interface [polypeptide binding]; other site 634500006520 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 634500006521 putative CheW interface [polypeptide binding]; other site 634500006522 alanine-tRNA ligase; Region: PLN02961 634500006523 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 634500006524 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500006525 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 634500006526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500006527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500006528 dimer interface [polypeptide binding]; other site 634500006529 conserved gate region; other site 634500006530 putative PBP binding loops; other site 634500006531 ABC-ATPase subunit interface; other site 634500006532 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634500006533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500006534 putative PBP binding loops; other site 634500006535 dimer interface [polypeptide binding]; other site 634500006536 ABC-ATPase subunit interface; other site 634500006537 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 634500006538 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500006539 Walker A/P-loop; other site 634500006540 ATP binding site [chemical binding]; other site 634500006541 Q-loop/lid; other site 634500006542 ABC transporter signature motif; other site 634500006543 Walker B; other site 634500006544 D-loop; other site 634500006545 H-loop/switch region; other site 634500006546 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500006547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500006548 Walker A/P-loop; other site 634500006549 ATP binding site [chemical binding]; other site 634500006550 Q-loop/lid; other site 634500006551 ABC transporter signature motif; other site 634500006552 Walker B; other site 634500006553 D-loop; other site 634500006554 H-loop/switch region; other site 634500006555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500006556 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500006557 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500006558 active site 634500006559 non-prolyl cis peptide bond; other site 634500006560 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 634500006561 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 634500006562 Flavin binding site [chemical binding]; other site 634500006563 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500006564 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006565 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 634500006566 amphipathic channel; other site 634500006567 Asn-Pro-Ala signature motifs; other site 634500006568 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 634500006569 DNA binding site [nucleotide binding] 634500006570 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 634500006571 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 634500006572 DNA binding residues [nucleotide binding] 634500006573 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500006574 dimerization interface [polypeptide binding]; other site 634500006575 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 634500006576 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 634500006577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 634500006578 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 634500006579 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 634500006580 Domain of unknown function (DUF333); Region: DUF333; pfam03891 634500006581 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 634500006582 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 634500006583 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500006584 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 634500006585 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 634500006586 putative active site [active] 634500006587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500006588 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 634500006589 Walker A/P-loop; other site 634500006590 ATP binding site [chemical binding]; other site 634500006591 Q-loop/lid; other site 634500006592 ABC transporter signature motif; other site 634500006593 Walker B; other site 634500006594 D-loop; other site 634500006595 H-loop/switch region; other site 634500006596 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 634500006597 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 634500006598 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 634500006599 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 634500006600 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 634500006601 NAD binding site [chemical binding]; other site 634500006602 catalytic Zn binding site [ion binding]; other site 634500006603 structural Zn binding site [ion binding]; other site 634500006604 silverDB:661Eb02395 634500006605 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500006606 haemagglutination activity domain; Region: Haemagg_act; pfam05860 634500006607 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 634500006608 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500006609 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500006610 RTX toxin acyltransferase family; Region: HlyC; pfam02794 634500006611 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 634500006612 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 634500006613 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 634500006614 GTP-binding protein YchF; Reviewed; Region: PRK09601 634500006615 YchF GTPase; Region: YchF; cd01900 634500006616 G1 box; other site 634500006617 GTP/Mg2+ binding site [chemical binding]; other site 634500006618 Switch I region; other site 634500006619 G2 box; other site 634500006620 Switch II region; other site 634500006621 G3 box; other site 634500006622 G4 box; other site 634500006623 G5 box; other site 634500006624 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 634500006625 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 634500006626 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 634500006627 Sulfate transporter family; Region: Sulfate_transp; pfam00916 634500006628 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 634500006629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500006630 TPR motif; other site 634500006631 binding surface 634500006632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006634 active site 634500006635 phosphorylation site [posttranslational modification] 634500006636 intermolecular recognition site; other site 634500006637 dimerization interface [polypeptide binding]; other site 634500006638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500006639 DNA binding residues [nucleotide binding] 634500006640 dimerization interface [polypeptide binding]; other site 634500006641 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 634500006642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500006643 substrate binding pocket [chemical binding]; other site 634500006644 membrane-bound complex binding site; other site 634500006645 hinge residues; other site 634500006646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500006647 substrate binding pocket [chemical binding]; other site 634500006648 membrane-bound complex binding site; other site 634500006649 hinge residues; other site 634500006650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500006651 dimer interface [polypeptide binding]; other site 634500006652 phosphorylation site [posttranslational modification] 634500006653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500006654 ATP binding site [chemical binding]; other site 634500006655 Mg2+ binding site [ion binding]; other site 634500006656 G-X-G motif; other site 634500006657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006658 active site 634500006659 phosphorylation site [posttranslational modification] 634500006660 intermolecular recognition site; other site 634500006661 dimerization interface [polypeptide binding]; other site 634500006662 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634500006663 putative binding surface; other site 634500006664 active site 634500006665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500006666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006667 active site 634500006668 phosphorylation site [posttranslational modification] 634500006669 intermolecular recognition site; other site 634500006670 dimerization interface [polypeptide binding]; other site 634500006671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500006672 DNA binding residues [nucleotide binding] 634500006673 dimerization interface [polypeptide binding]; other site 634500006674 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500006675 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 634500006676 substrate binding pocket [chemical binding]; other site 634500006677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500006678 substrate binding pocket [chemical binding]; other site 634500006679 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500006680 membrane-bound complex binding site; other site 634500006681 hinge residues; other site 634500006682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634500006683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500006684 dimer interface [polypeptide binding]; other site 634500006685 phosphorylation site [posttranslational modification] 634500006686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500006687 ATP binding site [chemical binding]; other site 634500006688 Mg2+ binding site [ion binding]; other site 634500006689 G-X-G motif; other site 634500006690 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 634500006691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006692 active site 634500006693 phosphorylation site [posttranslational modification] 634500006694 intermolecular recognition site; other site 634500006695 dimerization interface [polypeptide binding]; other site 634500006696 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500006697 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006698 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006699 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006700 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006701 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006702 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006703 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006704 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500006705 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006707 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006708 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006709 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006710 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006711 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006712 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006713 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006714 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 634500006715 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006716 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006717 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006718 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500006719 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 634500006720 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500006721 ligand binding site [chemical binding]; other site 634500006722 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 634500006723 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 634500006724 putative active site [active] 634500006725 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 634500006726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500006727 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 634500006728 Walker A/P-loop; other site 634500006729 ATP binding site [chemical binding]; other site 634500006730 Q-loop/lid; other site 634500006731 ABC transporter signature motif; other site 634500006732 Walker B; other site 634500006733 D-loop; other site 634500006734 H-loop/switch region; other site 634500006735 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 634500006736 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500006737 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500006738 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 634500006739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500006740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500006741 active site 634500006742 phosphorylation site [posttranslational modification] 634500006743 intermolecular recognition site; other site 634500006744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500006745 DNA binding residues [nucleotide binding] 634500006746 dimerization interface [polypeptide binding]; other site 634500006747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500006748 TPR motif; other site 634500006749 binding surface 634500006750 TPR repeat; Region: TPR_11; pfam13414 634500006751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500006752 binding surface 634500006753 TPR motif; other site 634500006754 Tetratricopeptide repeat; Region: TPR_16; pfam13432 634500006755 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634500006756 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 634500006757 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 634500006758 PapC N-terminal domain; Region: PapC_N; pfam13954 634500006759 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500006760 PapC C-terminal domain; Region: PapC_C; pfam13953 634500006761 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 634500006762 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 634500006763 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 634500006764 Fimbrial protein; Region: Fimbrial; cl01416 634500006765 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 634500006766 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 634500006767 putative active site [active] 634500006768 catalytic residue [active] 634500006769 hypothetical protein; Provisional; Region: PRK10692 634500006770 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500006771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500006772 metal binding site [ion binding]; metal-binding site 634500006773 active site 634500006774 I-site; other site 634500006775 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 634500006776 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 634500006777 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500006778 active site 634500006779 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 634500006780 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 634500006781 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 634500006782 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 634500006783 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 634500006784 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 634500006785 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 634500006786 tRNA; other site 634500006787 putative tRNA binding site [nucleotide binding]; other site 634500006788 putative NADP binding site [chemical binding]; other site 634500006789 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 634500006790 peptide chain release factor 1; Validated; Region: prfA; PRK00591 634500006791 This domain is found in peptide chain release factors; Region: PCRF; smart00937 634500006792 RF-1 domain; Region: RF-1; pfam00472 634500006793 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 634500006794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500006795 hypothetical protein; Provisional; Region: PRK10941 634500006796 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 634500006797 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 634500006798 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 634500006799 META domain; Region: META; cl01245 634500006800 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 634500006801 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 634500006802 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 634500006803 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 634500006804 putative active site pocket [active] 634500006805 dimerization interface [polypeptide binding]; other site 634500006806 putative catalytic residue [active] 634500006807 Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig...; Region: IlGF_like; cl02453 634500006808 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 634500006809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 634500006810 active site 634500006811 ATP binding site [chemical binding]; other site 634500006812 substrate binding site [chemical binding]; other site 634500006813 activation loop (A-loop); other site 634500006814 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 634500006815 active site 634500006816 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 634500006817 FHA domain; Region: FHA; pfam00498 634500006818 phosphopeptide binding site; other site 634500006819 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 634500006820 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 634500006821 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 634500006822 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 634500006823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500006824 ligand binding site [chemical binding]; other site 634500006825 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634500006826 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500006827 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 634500006828 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500006829 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 634500006830 TPP-binding site [chemical binding]; other site 634500006831 dimer interface [polypeptide binding]; other site 634500006832 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 634500006833 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634500006834 PYR/PP interface [polypeptide binding]; other site 634500006835 dimer interface [polypeptide binding]; other site 634500006836 TPP binding site [chemical binding]; other site 634500006837 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634500006838 short chain dehydrogenase; Provisional; Region: PRK06841 634500006839 classical (c) SDRs; Region: SDR_c; cd05233 634500006840 NAD(P) binding site [chemical binding]; other site 634500006841 active site 634500006842 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500006843 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500006844 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 634500006845 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500006846 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500006847 Walker A/P-loop; other site 634500006848 ATP binding site [chemical binding]; other site 634500006849 Q-loop/lid; other site 634500006850 ABC transporter signature motif; other site 634500006851 Walker B; other site 634500006852 D-loop; other site 634500006853 H-loop/switch region; other site 634500006854 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500006855 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500006856 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500006857 TM-ABC transporter signature motif; other site 634500006858 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 634500006859 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 634500006860 N- and C-terminal domain interface [polypeptide binding]; other site 634500006861 active site 634500006862 MgATP binding site [chemical binding]; other site 634500006863 catalytic site [active] 634500006864 metal binding site [ion binding]; metal-binding site 634500006865 putative homotetramer interface [polypeptide binding]; other site 634500006866 putative homodimer interface [polypeptide binding]; other site 634500006867 glycerol binding site [chemical binding]; other site 634500006868 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634500006869 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 634500006870 NAD binding site [chemical binding]; other site 634500006871 homotetramer interface [polypeptide binding]; other site 634500006872 homodimer interface [polypeptide binding]; other site 634500006873 active site 634500006874 substrate binding site [chemical binding]; other site 634500006875 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 634500006876 substrate binding site [chemical binding]; other site 634500006877 putative invasin; Provisional; Region: PRK10177 634500006878 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 634500006879 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500006880 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500006881 trimer interface [polypeptide binding]; other site 634500006882 eyelet of channel; other site 634500006883 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 634500006884 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500006885 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500006886 eyelet of channel; other site 634500006887 trimer interface [polypeptide binding]; other site 634500006888 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 634500006889 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500006890 inhibitor-cofactor binding pocket; inhibition site 634500006891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500006892 catalytic residue [active] 634500006893 arginine succinyltransferase; Provisional; Region: PRK10456 634500006894 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 634500006895 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 634500006896 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 634500006897 NAD(P) binding site [chemical binding]; other site 634500006898 catalytic residues [active] 634500006899 succinylarginine dihydrolase; Provisional; Region: PRK13281 634500006900 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 634500006901 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 634500006902 putative active site [active] 634500006903 Zn binding site [ion binding]; other site 634500006904 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 634500006905 dimer interface [polypeptide binding]; other site 634500006906 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 634500006907 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 634500006908 GIY-YIG motif/motif A; other site 634500006909 active site 634500006910 catalytic site [active] 634500006911 putative DNA binding site [nucleotide binding]; other site 634500006912 metal binding site [ion binding]; metal-binding site 634500006913 aromatic amino acid exporter; Provisional; Region: PRK11689 634500006914 EamA-like transporter family; Region: EamA; pfam00892 634500006915 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 634500006916 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 634500006917 homodimer interface [polypeptide binding]; other site 634500006918 NAD binding pocket [chemical binding]; other site 634500006919 ATP binding pocket [chemical binding]; other site 634500006920 Mg binding site [ion binding]; other site 634500006921 active-site loop [active] 634500006922 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 634500006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500006924 putative substrate translocation pore; other site 634500006925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500006926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500006927 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 634500006928 hydroperoxidase II; Provisional; Region: katE; PRK11249 634500006929 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 634500006930 tetramer interface [polypeptide binding]; other site 634500006931 heme binding pocket [chemical binding]; other site 634500006932 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 634500006933 domain interactions; other site 634500006934 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 634500006935 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634500006936 inner membrane protein; Provisional; Region: PRK11648 634500006937 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 634500006938 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634500006939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500006940 motif II; other site 634500006941 YniB-like protein; Region: YniB; pfam14002 634500006942 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 634500006943 Phosphotransferase enzyme family; Region: APH; pfam01636 634500006944 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 634500006945 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634500006946 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500006947 intersubunit interface [polypeptide binding]; other site 634500006948 Protein of unknown function, DUF481; Region: DUF481; cl01213 634500006949 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 634500006950 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 634500006951 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 634500006952 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 634500006953 active site 634500006954 dimer interface [polypeptide binding]; other site 634500006955 motif 1; other site 634500006956 motif 2; other site 634500006957 motif 3; other site 634500006958 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 634500006959 anticodon binding site; other site 634500006960 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 634500006961 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 634500006962 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 634500006963 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 634500006964 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 634500006965 23S rRNA binding site [nucleotide binding]; other site 634500006966 L21 binding site [polypeptide binding]; other site 634500006967 L13 binding site [polypeptide binding]; other site 634500006968 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 634500006969 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 634500006970 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 634500006971 dimer interface [polypeptide binding]; other site 634500006972 motif 1; other site 634500006973 active site 634500006974 motif 2; other site 634500006975 motif 3; other site 634500006976 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 634500006977 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 634500006978 putative tRNA-binding site [nucleotide binding]; other site 634500006979 B3/4 domain; Region: B3_4; pfam03483 634500006980 tRNA synthetase B5 domain; Region: B5; smart00874 634500006981 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 634500006982 dimer interface [polypeptide binding]; other site 634500006983 motif 1; other site 634500006984 motif 3; other site 634500006985 motif 2; other site 634500006986 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 634500006987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 634500006988 IHF dimer interface [polypeptide binding]; other site 634500006989 IHF - DNA interface [nucleotide binding]; other site 634500006990 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500006991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500006992 ABC-ATPase subunit interface; other site 634500006993 dimer interface [polypeptide binding]; other site 634500006994 putative PBP binding regions; other site 634500006995 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 634500006996 catalytic residues [active] 634500006997 dimer interface [polypeptide binding]; other site 634500006998 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 634500006999 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634500007000 Walker A/P-loop; other site 634500007001 ATP binding site [chemical binding]; other site 634500007002 Q-loop/lid; other site 634500007003 ABC transporter signature motif; other site 634500007004 Walker B; other site 634500007005 D-loop; other site 634500007006 H-loop/switch region; other site 634500007007 NlpC/P60 family; Region: NLPC_P60; pfam00877 634500007008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 634500007009 Uncharacterized conserved protein [Function unknown]; Region: COG0397 634500007010 hypothetical protein; Validated; Region: PRK00029 634500007011 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 634500007012 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 634500007013 PEP synthetase regulatory protein; Provisional; Region: PRK05339 634500007014 phosphoenolpyruvate synthase; Validated; Region: PRK06464 634500007015 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 634500007016 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 634500007017 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 634500007018 putative inner membrane protein; Provisional; Region: PRK10983 634500007019 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634500007020 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 634500007021 FAD binding domain; Region: FAD_binding_4; pfam01565 634500007022 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 634500007023 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 634500007024 CoenzymeA binding site [chemical binding]; other site 634500007025 subunit interaction site [polypeptide binding]; other site 634500007026 PHB binding site; other site 634500007027 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 634500007028 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 634500007029 putative ABC transporter; Region: ycf24; CHL00085 634500007030 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 634500007031 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 634500007032 Walker A/P-loop; other site 634500007033 ATP binding site [chemical binding]; other site 634500007034 Q-loop/lid; other site 634500007035 ABC transporter signature motif; other site 634500007036 Walker B; other site 634500007037 D-loop; other site 634500007038 H-loop/switch region; other site 634500007039 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 634500007040 FeS assembly protein SufD; Region: sufD; TIGR01981 634500007041 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 634500007042 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 634500007043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500007044 catalytic residue [active] 634500007045 cysteine desufuration protein SufE; Provisional; Region: PRK09296 634500007046 L,D-transpeptidase; Provisional; Region: PRK10190 634500007047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 634500007048 murein lipoprotein; Provisional; Region: PRK15396 634500007049 pyruvate kinase; Provisional; Region: PRK09206 634500007050 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 634500007051 domain interfaces; other site 634500007052 active site 634500007053 multidrug efflux protein; Reviewed; Region: PRK01766 634500007054 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 634500007055 cation binding site [ion binding]; other site 634500007056 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 634500007057 Lumazine binding domain; Region: Lum_binding; pfam00677 634500007058 Lumazine binding domain; Region: Lum_binding; pfam00677 634500007059 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 634500007060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500007061 S-adenosylmethionine binding site [chemical binding]; other site 634500007062 putative transporter; Provisional; Region: PRK11043 634500007063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007064 putative substrate translocation pore; other site 634500007065 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 634500007066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500007068 dimerization interface [polypeptide binding]; other site 634500007069 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 634500007070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500007071 DNA binding site [nucleotide binding] 634500007072 domain linker motif; other site 634500007073 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 634500007074 dimerization interface [polypeptide binding]; other site 634500007075 ligand binding site [chemical binding]; other site 634500007076 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 634500007077 NlpC/P60 family; Region: NLPC_P60; pfam00877 634500007078 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 634500007079 putative GSH binding site [chemical binding]; other site 634500007080 catalytic residues [active] 634500007081 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634500007082 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 634500007083 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 634500007084 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 634500007085 dimer interface [polypeptide binding]; other site 634500007086 catalytic site [active] 634500007087 putative active site [active] 634500007088 putative substrate binding site [chemical binding]; other site 634500007089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500007090 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 634500007091 dimer interface [polypeptide binding]; other site 634500007092 active site 634500007093 metal binding site [ion binding]; metal-binding site 634500007094 glutathione binding site [chemical binding]; other site 634500007095 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500007096 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500007097 FMN binding site [chemical binding]; other site 634500007098 active site 634500007099 substrate binding site [chemical binding]; other site 634500007100 catalytic residue [active] 634500007101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007103 Predicted Fe-S protein [General function prediction only]; Region: COG3313 634500007104 Fusaric acid resistance protein family; Region: FUSC; pfam04632 634500007105 Fusaric acid resistance protein family; Region: FUSC; pfam04632 634500007106 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500007107 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 634500007108 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500007109 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500007110 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 634500007111 transcriptional regulator SlyA; Provisional; Region: PRK03573 634500007112 MarR family; Region: MarR; pfam01047 634500007113 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 634500007114 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 634500007115 lysozyme inhibitor; Provisional; Region: PRK11372 634500007116 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 634500007117 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 634500007118 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 634500007119 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 634500007120 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 634500007121 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 634500007122 active site 634500007123 HIGH motif; other site 634500007124 dimer interface [polypeptide binding]; other site 634500007125 KMSKS motif; other site 634500007126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500007127 RNA binding surface [nucleotide binding]; other site 634500007128 pyridoxamine kinase; Validated; Region: PRK05756 634500007129 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 634500007130 dimer interface [polypeptide binding]; other site 634500007131 pyridoxal binding site [chemical binding]; other site 634500007132 ATP binding site [chemical binding]; other site 634500007133 glutathionine S-transferase; Provisional; Region: PRK10542 634500007134 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 634500007135 C-terminal domain interface [polypeptide binding]; other site 634500007136 GSH binding site (G-site) [chemical binding]; other site 634500007137 dimer interface [polypeptide binding]; other site 634500007138 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 634500007139 dimer interface [polypeptide binding]; other site 634500007140 N-terminal domain interface [polypeptide binding]; other site 634500007141 substrate binding pocket (H-site) [chemical binding]; other site 634500007142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007144 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 634500007145 putative effector binding pocket; other site 634500007146 putative dimerization interface [polypeptide binding]; other site 634500007147 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 634500007148 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 634500007149 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 634500007150 putative N-terminal domain interface [polypeptide binding]; other site 634500007151 putative dimer interface [polypeptide binding]; other site 634500007152 putative substrate binding pocket (H-site) [chemical binding]; other site 634500007153 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 634500007154 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 634500007155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007156 putative substrate translocation pore; other site 634500007157 POT family; Region: PTR2; pfam00854 634500007158 transcriptional regulator BetI; Validated; Region: PRK00767 634500007159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007160 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 634500007161 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 634500007162 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 634500007163 tetrameric interface [polypeptide binding]; other site 634500007164 NAD binding site [chemical binding]; other site 634500007165 catalytic residues [active] 634500007166 choline dehydrogenase; Validated; Region: PRK02106 634500007167 lycopene cyclase; Region: lycopene_cycl; TIGR01789 634500007168 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500007169 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500007170 putative transporter; Provisional; Region: PRK10504 634500007171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007172 putative substrate translocation pore; other site 634500007173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007174 endonuclease III; Provisional; Region: PRK10702 634500007175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634500007176 minor groove reading motif; other site 634500007177 helix-hairpin-helix signature motif; other site 634500007178 substrate binding pocket [chemical binding]; other site 634500007179 active site 634500007180 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 634500007181 electron transport complex RsxE subunit; Provisional; Region: PRK12405 634500007182 electron transport complex protein RnfG; Validated; Region: PRK01908 634500007183 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 634500007184 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 634500007185 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 634500007186 SLBB domain; Region: SLBB; pfam10531 634500007187 electron transport complex protein RnfB; Provisional; Region: PRK05113 634500007188 Putative Fe-S cluster; Region: FeS; cl17515 634500007189 4Fe-4S binding domain; Region: Fer4; pfam00037 634500007190 electron transport complex protein RsxA; Provisional; Region: PRK05151 634500007191 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 634500007192 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 634500007193 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 634500007194 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500007195 putative ligand binding site [chemical binding]; other site 634500007196 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500007197 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500007198 Walker A/P-loop; other site 634500007199 ATP binding site [chemical binding]; other site 634500007200 Q-loop/lid; other site 634500007201 ABC transporter signature motif; other site 634500007202 Walker B; other site 634500007203 D-loop; other site 634500007204 H-loop/switch region; other site 634500007205 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500007206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007208 TM-ABC transporter signature motif; other site 634500007209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007210 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007211 TM-ABC transporter signature motif; other site 634500007212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500007215 dimerization interface [polypeptide binding]; other site 634500007216 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 634500007217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500007218 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 634500007219 active site 634500007220 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 634500007221 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 634500007222 L-arabinose isomerase; Provisional; Region: PRK02929 634500007223 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 634500007224 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 634500007225 trimer interface [polypeptide binding]; other site 634500007226 putative substrate binding site [chemical binding]; other site 634500007227 putative metal binding site [ion binding]; other site 634500007228 ribulokinase; Provisional; Region: PRK04123 634500007229 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 634500007230 N- and C-terminal domain interface [polypeptide binding]; other site 634500007231 active site 634500007232 MgATP binding site [chemical binding]; other site 634500007233 catalytic site [active] 634500007234 metal binding site [ion binding]; metal-binding site 634500007235 carbohydrate binding site [chemical binding]; other site 634500007236 homodimer interface [polypeptide binding]; other site 634500007237 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 634500007238 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 634500007239 ligand binding site [chemical binding]; other site 634500007240 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 634500007241 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500007242 Walker A/P-loop; other site 634500007243 ATP binding site [chemical binding]; other site 634500007244 Q-loop/lid; other site 634500007245 ABC transporter signature motif; other site 634500007246 Walker B; other site 634500007247 D-loop; other site 634500007248 H-loop/switch region; other site 634500007249 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500007250 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007252 TM-ABC transporter signature motif; other site 634500007253 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 634500007254 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500007255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007257 putative oxidoreductase; Provisional; Region: PRK11579 634500007258 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500007259 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500007260 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 634500007261 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 634500007262 active site 634500007263 purine riboside binding site [chemical binding]; other site 634500007264 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 634500007265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500007266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500007267 homodimer interface [polypeptide binding]; other site 634500007268 catalytic residue [active] 634500007269 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 634500007270 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 634500007271 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500007272 active site turn [active] 634500007273 phosphorylation site [posttranslational modification] 634500007274 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 634500007275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500007276 DNA binding site [nucleotide binding] 634500007277 domain linker motif; other site 634500007278 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 634500007279 putative dimerization interface [polypeptide binding]; other site 634500007280 putative ligand binding site [chemical binding]; other site 634500007281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 634500007282 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 634500007283 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 634500007284 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 634500007285 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 634500007286 fumarate hydratase; Reviewed; Region: fumC; PRK00485 634500007287 Class II fumarases; Region: Fumarase_classII; cd01362 634500007288 active site 634500007289 tetramer interface [polypeptide binding]; other site 634500007290 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 634500007291 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 634500007292 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 634500007293 Putative ammonia monooxygenase; Region: AmoA; pfam05145 634500007294 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 634500007295 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 634500007296 choline transport protein BetT; Provisional; Region: PRK09928 634500007297 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 634500007298 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500007299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007301 methionine sulfoxide reductase A; Provisional; Region: PRK14054 634500007302 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007304 putative substrate translocation pore; other site 634500007305 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 634500007306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007307 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 634500007308 dimerization interface [polypeptide binding]; other site 634500007309 substrate binding pocket [chemical binding]; other site 634500007310 MarR family; Region: MarR_2; cl17246 634500007311 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634500007312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500007313 nucleotide binding site [chemical binding]; other site 634500007314 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634500007315 AAA domain; Region: AAA_26; pfam13500 634500007316 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 634500007317 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 634500007318 Walker A/P-loop; other site 634500007319 ATP binding site [chemical binding]; other site 634500007320 Q-loop/lid; other site 634500007321 ABC transporter signature motif; other site 634500007322 Walker B; other site 634500007323 D-loop; other site 634500007324 H-loop/switch region; other site 634500007325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 634500007326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007327 dimer interface [polypeptide binding]; other site 634500007328 conserved gate region; other site 634500007329 ABC-ATPase subunit interface; other site 634500007330 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 634500007331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007332 dimer interface [polypeptide binding]; other site 634500007333 conserved gate region; other site 634500007334 putative PBP binding loops; other site 634500007335 ABC-ATPase subunit interface; other site 634500007336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500007337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007339 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 634500007340 hypothetical protein; Provisional; Region: PRK13659 634500007341 hypothetical protein; Provisional; Region: PRK02237 634500007342 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 634500007343 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 634500007344 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 634500007345 active site 634500007346 Zn binding site [ion binding]; other site 634500007347 sensor protein RstB; Provisional; Region: PRK10604 634500007348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500007349 dimerization interface [polypeptide binding]; other site 634500007350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500007351 dimer interface [polypeptide binding]; other site 634500007352 phosphorylation site [posttranslational modification] 634500007353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500007354 ATP binding site [chemical binding]; other site 634500007355 Mg2+ binding site [ion binding]; other site 634500007356 G-X-G motif; other site 634500007357 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 634500007358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500007359 active site 634500007360 phosphorylation site [posttranslational modification] 634500007361 intermolecular recognition site; other site 634500007362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500007363 DNA binding site [nucleotide binding] 634500007364 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 634500007365 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500007366 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500007367 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500007368 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 634500007369 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 634500007370 ligand binding site [chemical binding]; other site 634500007371 homodimer interface [polypeptide binding]; other site 634500007372 NAD(P) binding site [chemical binding]; other site 634500007373 trimer interface B [polypeptide binding]; other site 634500007374 trimer interface A [polypeptide binding]; other site 634500007375 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 634500007376 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 634500007377 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 634500007378 universal stress protein UspE; Provisional; Region: PRK11175 634500007379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634500007380 Ligand Binding Site [chemical binding]; other site 634500007381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634500007382 Ligand Binding Site [chemical binding]; other site 634500007383 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500007384 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500007385 active site 634500007386 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 634500007387 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 634500007388 ligand binding site [chemical binding]; other site 634500007389 flexible hinge region; other site 634500007390 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 634500007391 putative switch regulator; other site 634500007392 non-specific DNA interactions [nucleotide binding]; other site 634500007393 DNA binding site [nucleotide binding] 634500007394 sequence specific DNA binding site [nucleotide binding]; other site 634500007395 putative cAMP binding site [chemical binding]; other site 634500007396 polyol permease family; Region: 2A0118; TIGR00897 634500007397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007398 putative substrate translocation pore; other site 634500007399 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 634500007400 N- and C-terminal domain interface [polypeptide binding]; other site 634500007401 D-xylulose kinase; Region: XylB; TIGR01312 634500007402 active site 634500007403 MgATP binding site [chemical binding]; other site 634500007404 catalytic site [active] 634500007405 metal binding site [ion binding]; metal-binding site 634500007406 xylulose binding site [chemical binding]; other site 634500007407 homodimer interface [polypeptide binding]; other site 634500007408 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 634500007409 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 634500007410 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 634500007411 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 634500007412 MarR family; Region: MarR_2; pfam12802 634500007413 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 634500007414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 634500007415 Smr domain; Region: Smr; pfam01713 634500007416 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 634500007417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500007419 dimerization interface [polypeptide binding]; other site 634500007420 benzoate transport; Region: 2A0115; TIGR00895 634500007421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007422 putative substrate translocation pore; other site 634500007423 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 634500007424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 634500007425 Predicted membrane protein [Function unknown]; Region: COG2259 634500007426 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 634500007427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 634500007428 substrate binding pocket [chemical binding]; other site 634500007429 catalytic triad [active] 634500007430 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634500007431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500007432 dimerization interface [polypeptide binding]; other site 634500007433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500007434 dimer interface [polypeptide binding]; other site 634500007435 putative CheW interface [polypeptide binding]; other site 634500007436 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 634500007437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500007439 dimerization interface [polypeptide binding]; other site 634500007440 putative aminotransferase; Provisional; Region: PRK12414 634500007441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500007442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500007443 homodimer interface [polypeptide binding]; other site 634500007444 catalytic residue [active] 634500007445 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 634500007446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500007447 substrate binding pocket [chemical binding]; other site 634500007448 membrane-bound complex binding site; other site 634500007449 hinge residues; other site 634500007450 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 634500007451 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 634500007452 metal binding site [ion binding]; metal-binding site 634500007453 dimer interface [polypeptide binding]; other site 634500007454 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 634500007455 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500007456 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 634500007457 peptide binding site [polypeptide binding]; other site 634500007458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500007459 salt bridge; other site 634500007460 non-specific DNA binding site [nucleotide binding]; other site 634500007461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500007462 sequence-specific DNA binding site [nucleotide binding]; other site 634500007463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500007466 dimerization interface [polypeptide binding]; other site 634500007467 hypothetical protein; Provisional; Region: PRK07079 634500007468 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 634500007469 metal binding site [ion binding]; metal-binding site 634500007470 putative dimer interface [polypeptide binding]; other site 634500007471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007472 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500007473 putative substrate translocation pore; other site 634500007474 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 634500007475 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 634500007476 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634500007477 NAD binding site [chemical binding]; other site 634500007478 catalytic residues [active] 634500007479 substrate binding site [chemical binding]; other site 634500007480 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 634500007481 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 634500007482 transcriptional activator RhaR; Provisional; Region: PRK13501 634500007483 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500007484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007485 transcriptional activator RhaS; Provisional; Region: PRK13503 634500007486 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500007487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007488 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 634500007489 N- and C-terminal domain interface [polypeptide binding]; other site 634500007490 active site 634500007491 putative catalytic site [active] 634500007492 metal binding site [ion binding]; metal-binding site 634500007493 ATP binding site [chemical binding]; other site 634500007494 rhamnulokinase; Provisional; Region: rhaB; PRK10640 634500007495 carbohydrate binding site [chemical binding]; other site 634500007496 L-rhamnose isomerase; Provisional; Region: PRK01076 634500007497 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 634500007498 intersubunit interface [polypeptide binding]; other site 634500007499 active site 634500007500 Zn2+ binding site [ion binding]; other site 634500007501 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 634500007502 putative arabinose transporter; Provisional; Region: PRK03545 634500007503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007504 putative substrate translocation pore; other site 634500007505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500007506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007507 putative substrate translocation pore; other site 634500007508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500007510 salt bridge; other site 634500007511 non-specific DNA binding site [nucleotide binding]; other site 634500007512 sequence-specific DNA binding site [nucleotide binding]; other site 634500007513 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634500007514 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 634500007515 NAD binding site [chemical binding]; other site 634500007516 Predicted transcriptional regulator [Transcription]; Region: COG1959 634500007517 Transcriptional regulator; Region: Rrf2; pfam02082 634500007518 Transcriptional regulator; Region: Rrf2; cl17282 634500007519 Cupin; Region: Cupin_6; pfam12852 634500007520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007521 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500007522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007523 short chain dehydrogenase; Provisional; Region: PRK06180 634500007524 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 634500007525 NADP binding site [chemical binding]; other site 634500007526 active site 634500007527 steroid binding site; other site 634500007528 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634500007529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 634500007530 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500007531 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 634500007532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007533 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 634500007534 Predicted permeases [General function prediction only]; Region: COG0679 634500007535 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500007536 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 634500007537 putative ligand binding site [chemical binding]; other site 634500007538 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 634500007539 active site 634500007540 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 634500007541 RNAase interaction site [polypeptide binding]; other site 634500007542 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 634500007543 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500007544 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634500007545 metal binding site [ion binding]; metal-binding site 634500007546 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 634500007547 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 634500007548 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 634500007549 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 634500007550 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 634500007551 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 634500007552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500007553 Walker A/P-loop; other site 634500007554 ATP binding site [chemical binding]; other site 634500007555 Q-loop/lid; other site 634500007556 ABC transporter signature motif; other site 634500007557 Walker B; other site 634500007558 D-loop; other site 634500007559 H-loop/switch region; other site 634500007560 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500007561 Walker A/P-loop; other site 634500007562 ATP binding site [chemical binding]; other site 634500007563 Q-loop/lid; other site 634500007564 ABC transporter signature motif; other site 634500007565 Walker B; other site 634500007566 D-loop; other site 634500007567 H-loop/switch region; other site 634500007568 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500007569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634500007570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007571 putative PBP binding loops; other site 634500007572 dimer interface [polypeptide binding]; other site 634500007573 ABC-ATPase subunit interface; other site 634500007574 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500007575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007576 dimer interface [polypeptide binding]; other site 634500007577 conserved gate region; other site 634500007578 ABC-ATPase subunit interface; other site 634500007579 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500007580 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 634500007581 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634500007582 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634500007583 Walker A/P-loop; other site 634500007584 ATP binding site [chemical binding]; other site 634500007585 Q-loop/lid; other site 634500007586 ABC transporter signature motif; other site 634500007587 Walker B; other site 634500007588 D-loop; other site 634500007589 H-loop/switch region; other site 634500007590 NIL domain; Region: NIL; pfam09383 634500007591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007592 dimer interface [polypeptide binding]; other site 634500007593 conserved gate region; other site 634500007594 putative PBP binding loops; other site 634500007595 ABC-ATPase subunit interface; other site 634500007596 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634500007597 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634500007598 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634500007599 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634500007600 dimer interface [polypeptide binding]; other site 634500007601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500007602 catalytic residue [active] 634500007603 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500007604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500007605 substrate binding pocket [chemical binding]; other site 634500007606 membrane-bound complex binding site; other site 634500007607 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 634500007608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500007609 Walker A motif; other site 634500007610 ATP binding site [chemical binding]; other site 634500007611 Walker B motif; other site 634500007612 arginine finger; other site 634500007613 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 634500007614 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500007615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500007616 substrate binding pocket [chemical binding]; other site 634500007617 membrane-bound complex binding site; other site 634500007618 hinge residues; other site 634500007619 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 634500007620 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500007621 active site 634500007622 dimer interface [polypeptide binding]; other site 634500007623 non-prolyl cis peptide bond; other site 634500007624 insertion regions; other site 634500007625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 634500007626 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 634500007627 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500007628 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500007629 active site 634500007630 non-prolyl cis peptide bond; other site 634500007631 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634500007632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500007633 Walker A/P-loop; other site 634500007634 ATP binding site [chemical binding]; other site 634500007635 Q-loop/lid; other site 634500007636 ABC transporter signature motif; other site 634500007637 Walker B; other site 634500007638 D-loop; other site 634500007639 H-loop/switch region; other site 634500007640 NIL domain; Region: NIL; cl09633 634500007641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007642 dimer interface [polypeptide binding]; other site 634500007643 conserved gate region; other site 634500007644 ABC-ATPase subunit interface; other site 634500007645 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634500007646 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 634500007647 benzoate transport; Region: 2A0115; TIGR00895 634500007648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007650 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 634500007651 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 634500007652 Flavin binding site [chemical binding]; other site 634500007653 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500007654 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500007655 active site 634500007656 non-prolyl cis peptide bond; other site 634500007657 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 634500007658 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500007659 putative ligand binding site [chemical binding]; other site 634500007660 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500007661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500007662 Walker A/P-loop; other site 634500007663 ATP binding site [chemical binding]; other site 634500007664 Q-loop/lid; other site 634500007665 ABC transporter signature motif; other site 634500007666 Walker B; other site 634500007667 D-loop; other site 634500007668 H-loop/switch region; other site 634500007669 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500007670 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007672 TM-ABC transporter signature motif; other site 634500007673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007674 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007675 TM-ABC transporter signature motif; other site 634500007676 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500007677 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500007678 active site 634500007679 non-prolyl cis peptide bond; other site 634500007680 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 634500007681 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 634500007682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634500007683 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500007684 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634500007685 metal binding site [ion binding]; metal-binding site 634500007686 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500007687 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500007688 active site 634500007689 non-prolyl cis peptide bond; other site 634500007690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500007691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500007692 substrate binding pocket [chemical binding]; other site 634500007693 membrane-bound complex binding site; other site 634500007694 hinge residues; other site 634500007695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500007696 Coenzyme A binding pocket [chemical binding]; other site 634500007697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500007698 dimer interface [polypeptide binding]; other site 634500007699 conserved gate region; other site 634500007700 putative PBP binding loops; other site 634500007701 ABC-ATPase subunit interface; other site 634500007702 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500007703 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500007704 Walker A/P-loop; other site 634500007705 ATP binding site [chemical binding]; other site 634500007706 Q-loop/lid; other site 634500007707 ABC transporter signature motif; other site 634500007708 Walker B; other site 634500007709 D-loop; other site 634500007710 H-loop/switch region; other site 634500007711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500007712 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500007713 substrate binding pocket [chemical binding]; other site 634500007714 membrane-bound complex binding site; other site 634500007715 hinge residues; other site 634500007716 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 634500007717 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500007718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500007719 salt bridge; other site 634500007720 non-specific DNA binding site [nucleotide binding]; other site 634500007721 sequence-specific DNA binding site [nucleotide binding]; other site 634500007722 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 634500007723 Virulence factor SrfB; Region: SrfB; pfam07520 634500007724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500007725 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 634500007726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500007727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500007728 PAS domain; Region: PAS_9; pfam13426 634500007729 putative active site [active] 634500007730 heme pocket [chemical binding]; other site 634500007731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500007732 PAS domain; Region: PAS_9; pfam13426 634500007733 putative active site [active] 634500007734 heme pocket [chemical binding]; other site 634500007735 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500007736 dimer interface [polypeptide binding]; other site 634500007737 putative CheW interface [polypeptide binding]; other site 634500007738 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634500007739 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 634500007740 putative NAD(P) binding site [chemical binding]; other site 634500007741 putative substrate binding site [chemical binding]; other site 634500007742 catalytic Zn binding site [ion binding]; other site 634500007743 structural Zn binding site [ion binding]; other site 634500007744 dimer interface [polypeptide binding]; other site 634500007745 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 634500007746 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 634500007747 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 634500007748 NAD(P) binding site [chemical binding]; other site 634500007749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500007750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500007751 C factor cell-cell signaling protein; Provisional; Region: PRK09009 634500007752 NAD(P) binding site [chemical binding]; other site 634500007753 active site 634500007754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007756 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 634500007757 putative substrate binding pocket [chemical binding]; other site 634500007758 putative dimerization interface [polypeptide binding]; other site 634500007759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007761 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 634500007762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 634500007763 Protein of unknown function (DUF330); Region: DUF330; pfam03886 634500007764 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 634500007765 mce related protein; Region: MCE; pfam02470 634500007766 mce related protein; Region: MCE; pfam02470 634500007767 mce related protein; Region: MCE; pfam02470 634500007768 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 634500007769 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500007770 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500007771 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 634500007772 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 634500007773 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 634500007774 active site 634500007775 Protein of unknown function (DUF796); Region: DUF796; cl01226 634500007776 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 634500007777 Predicted transcriptional regulators [Transcription]; Region: COG1695 634500007778 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 634500007779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500007780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500007781 metal binding site [ion binding]; metal-binding site 634500007782 active site 634500007783 I-site; other site 634500007784 Uncharacterized protein conserved in archaea (DUF2102); Region: DUF2102; cl01650 634500007785 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 634500007786 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500007787 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 634500007788 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 634500007789 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 634500007790 Oxygen tolerance; Region: BatD; pfam13584 634500007791 von Willebrand factor type A domain; Region: VWA_2; pfam13519 634500007792 metal ion-dependent adhesion site (MIDAS); other site 634500007793 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 634500007794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500007795 binding surface 634500007796 TPR motif; other site 634500007797 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 634500007798 metal ion-dependent adhesion site (MIDAS); other site 634500007799 Protein of unknown function DUF58; Region: DUF58; pfam01882 634500007800 MoxR-like ATPases [General function prediction only]; Region: COG0714 634500007801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500007802 Walker A motif; other site 634500007803 ATP binding site [chemical binding]; other site 634500007804 Walker B motif; other site 634500007805 arginine finger; other site 634500007806 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 634500007807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500007808 FeS/SAM binding site; other site 634500007809 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 634500007810 silverDB:661Eb02859 634500007811 silverDB:661Eb02860 634500007812 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 634500007813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007815 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634500007816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007817 putative substrate translocation pore; other site 634500007818 NlpC/P60 family; Region: NLPC_P60; pfam00877 634500007819 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 634500007820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007821 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 634500007822 dimerization interface [polypeptide binding]; other site 634500007823 substrate binding pocket [chemical binding]; other site 634500007824 succinic semialdehyde dehydrogenase; Region: PLN02278 634500007825 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 634500007826 tetramerization interface [polypeptide binding]; other site 634500007827 NAD(P) binding site [chemical binding]; other site 634500007828 catalytic residues [active] 634500007829 mannonate dehydratase; Provisional; Region: PRK03906 634500007830 mannonate dehydratase; Region: uxuA; TIGR00695 634500007831 fructuronate transporter; Provisional; Region: PRK10034 634500007832 gluconate transporter; Region: gntP; TIGR00791 634500007833 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500007834 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 634500007835 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500007836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500007837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007838 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 634500007839 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 634500007840 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 634500007841 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 634500007842 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500007843 putative active site [active] 634500007844 putative metal binding site [ion binding]; other site 634500007845 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 634500007846 active site 634500007847 catalytic residues [active] 634500007848 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 634500007849 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 634500007850 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 634500007851 catalytic site [active] 634500007852 active site 634500007853 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 634500007854 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 634500007855 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 634500007856 active site 634500007857 catalytic site [active] 634500007858 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 634500007859 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 634500007860 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 634500007861 active site 634500007862 catalytic site [active] 634500007863 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500007864 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500007865 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500007866 dimerization interface [polypeptide binding]; other site 634500007867 putative DNA binding site [nucleotide binding]; other site 634500007868 putative Zn2+ binding site [ion binding]; other site 634500007869 short chain dehydrogenase; Provisional; Region: PRK06500 634500007870 classical (c) SDRs; Region: SDR_c; cd05233 634500007871 NAD(P) binding site [chemical binding]; other site 634500007872 active site 634500007873 Uncharacterized conserved protein [Function unknown]; Region: COG3268 634500007874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500007875 NAD(P) binding site [chemical binding]; other site 634500007876 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 634500007877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500007878 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 634500007879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500007880 Helix-turn-helix domain; Region: HTH_18; pfam12833 634500007881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007883 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 634500007884 putative effector binding pocket; other site 634500007885 putative dimerization interface [polypeptide binding]; other site 634500007886 classical (c) SDRs; Region: SDR_c; cd05233 634500007887 short chain dehydrogenase; Validated; Region: PRK07069 634500007888 NAD(P) binding site [chemical binding]; other site 634500007889 active site 634500007890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 634500007891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500007892 NAD(P) binding site [chemical binding]; other site 634500007893 active site 634500007894 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 634500007895 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500007896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500007897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007899 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500007900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500007901 putative substrate translocation pore; other site 634500007902 oxidoreductase; Provisional; Region: PRK12742 634500007903 classical (c) SDRs; Region: SDR_c; cd05233 634500007904 NAD(P) binding site [chemical binding]; other site 634500007905 active site 634500007906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500007907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500007908 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 634500007909 putative effector binding pocket; other site 634500007910 putative dimerization interface [polypeptide binding]; other site 634500007911 short chain dehydrogenase; Provisional; Region: PRK06500 634500007912 classical (c) SDRs; Region: SDR_c; cd05233 634500007913 NAD(P) binding site [chemical binding]; other site 634500007914 active site 634500007915 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 634500007916 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 634500007917 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500007918 ligand binding site [chemical binding]; other site 634500007919 dimerization interface [polypeptide binding]; other site 634500007920 zinc binding site [ion binding]; other site 634500007921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500007922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500007923 Walker A/P-loop; other site 634500007924 ATP binding site [chemical binding]; other site 634500007925 Q-loop/lid; other site 634500007926 ABC transporter signature motif; other site 634500007927 Walker B; other site 634500007928 D-loop; other site 634500007929 H-loop/switch region; other site 634500007930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500007931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500007932 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500007933 TM-ABC transporter signature motif; other site 634500007934 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 634500007935 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500007936 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500007937 putative active site [active] 634500007938 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 634500007939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500007940 substrate binding site [chemical binding]; other site 634500007941 dimer interface [polypeptide binding]; other site 634500007942 ATP binding site [chemical binding]; other site 634500007943 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500007944 DNA binding site [nucleotide binding] 634500007945 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500007946 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500007947 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500007948 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500007949 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500007950 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500007951 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500007952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500007953 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500007954 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500007955 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 634500007956 Metal-binding active site; metal-binding site 634500007957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 634500007958 DNA binding site [nucleotide binding] 634500007959 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 634500007960 putative chaperone protein EcpD; Provisional; Region: PRK09926 634500007961 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 634500007962 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 634500007963 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 634500007964 PapC N-terminal domain; Region: PapC_N; pfam13954 634500007965 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500007966 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 634500007967 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 634500007968 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 634500007969 haemagglutination activity domain; Region: Haemagg_act; pfam05860 634500007970 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500007971 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500007974 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 634500007975 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500007976 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500007977 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634500007978 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 634500007979 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634500007980 dimer interface [polypeptide binding]; other site 634500007981 active site 634500007982 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 634500007983 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500007984 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634500007985 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 634500007986 NmrA-like family; Region: NmrA; pfam05368 634500007987 NADP binding site [chemical binding]; other site 634500007988 active site 634500007989 regulatory binding site [polypeptide binding]; other site 634500007990 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 634500007991 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 634500007992 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 634500007993 haemagglutination activity domain; Region: Haemagg_act; pfam05860 634500007994 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500007995 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500007996 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500007997 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 634500007998 silverDB:661Eb02941 634500007999 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 634500008000 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 634500008001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500008002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500008003 Coenzyme A binding pocket [chemical binding]; other site 634500008004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500008005 PAS domain; Region: PAS_9; pfam13426 634500008006 putative active site [active] 634500008007 heme pocket [chemical binding]; other site 634500008008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500008009 PAS domain; Region: PAS_9; pfam13426 634500008010 putative active site [active] 634500008011 heme pocket [chemical binding]; other site 634500008012 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500008013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500008014 dimer interface [polypeptide binding]; other site 634500008015 putative CheW interface [polypeptide binding]; other site 634500008016 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 634500008017 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 634500008018 active site 634500008019 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500008020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500008021 Walker A/P-loop; other site 634500008022 ATP binding site [chemical binding]; other site 634500008023 Q-loop/lid; other site 634500008024 ABC transporter signature motif; other site 634500008025 Walker B; other site 634500008026 D-loop; other site 634500008027 H-loop/switch region; other site 634500008028 TOBE domain; Region: TOBE_2; pfam08402 634500008029 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 634500008030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008031 dimer interface [polypeptide binding]; other site 634500008032 conserved gate region; other site 634500008033 putative PBP binding loops; other site 634500008034 ABC-ATPase subunit interface; other site 634500008035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008036 dimer interface [polypeptide binding]; other site 634500008037 conserved gate region; other site 634500008038 putative PBP binding loops; other site 634500008039 ABC-ATPase subunit interface; other site 634500008040 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 634500008041 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500008042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500008043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500008044 DNA binding site [nucleotide binding] 634500008045 domain linker motif; other site 634500008046 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 634500008047 putative dimerization interface [polypeptide binding]; other site 634500008048 putative ligand binding site [chemical binding]; other site 634500008049 Uncharacterized conserved protein [Function unknown]; Region: COG3791 634500008050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 634500008051 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 634500008052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500008053 Coenzyme A binding pocket [chemical binding]; other site 634500008054 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 634500008055 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 634500008056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 634500008057 Core-2/I-Branching enzyme; Region: Branch; pfam02485 634500008058 Fic family protein [Function unknown]; Region: COG3177 634500008059 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 634500008060 Fic/DOC family; Region: Fic; pfam02661 634500008061 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 634500008062 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500008063 inhibitor-cofactor binding pocket; inhibition site 634500008064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008065 catalytic residue [active] 634500008066 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 634500008067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008068 catalytic residue [active] 634500008069 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 634500008070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634500008071 putative NAD(P) binding site [chemical binding]; other site 634500008072 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 634500008073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500008074 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 634500008075 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 634500008076 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 634500008077 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 634500008078 conserved cys residue [active] 634500008079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500008080 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 634500008081 Protein of unknown function (DUF2767); Region: DUF2767; cl08104 634500008082 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 634500008083 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 634500008084 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 634500008085 tetramer interface [polypeptide binding]; other site 634500008086 heme binding pocket [chemical binding]; other site 634500008087 NADPH binding site [chemical binding]; other site 634500008088 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 634500008089 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 634500008090 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 634500008091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500008092 Coenzyme A binding pocket [chemical binding]; other site 634500008093 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 634500008094 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 634500008095 metal binding site [ion binding]; metal-binding site 634500008096 substrate binding pocket [chemical binding]; other site 634500008097 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500008098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500008099 DNA-binding site [nucleotide binding]; DNA binding site 634500008100 FCD domain; Region: FCD; pfam07729 634500008101 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 634500008102 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 634500008103 NADP binding site [chemical binding]; other site 634500008104 homodimer interface [polypeptide binding]; other site 634500008105 active site 634500008106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008107 D-galactonate transporter; Region: 2A0114; TIGR00893 634500008108 putative substrate translocation pore; other site 634500008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008110 D-galactonate transporter; Region: 2A0114; TIGR00893 634500008111 putative substrate translocation pore; other site 634500008112 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 634500008113 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 634500008114 putative NAD(P) binding site [chemical binding]; other site 634500008115 catalytic Zn binding site [ion binding]; other site 634500008116 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 634500008117 active site 634500008118 zinc binding site [ion binding]; other site 634500008119 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 634500008120 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 634500008121 NADP binding site [chemical binding]; other site 634500008122 dimer interface [polypeptide binding]; other site 634500008123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500008124 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 634500008125 NAD(P) binding site [chemical binding]; other site 634500008126 active site 634500008127 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500008128 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500008129 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 634500008130 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 634500008131 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 634500008132 NAD(P) binding site [chemical binding]; other site 634500008133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634500008134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500008135 putative DNA binding site [nucleotide binding]; other site 634500008136 putative Zn2+ binding site [ion binding]; other site 634500008137 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 634500008138 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 634500008139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634500008140 phosphate binding site [ion binding]; other site 634500008141 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 634500008142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500008143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500008144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500008145 DNA binding site [nucleotide binding] 634500008146 domain linker motif; other site 634500008147 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500008148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008149 D-galactonate transporter; Region: 2A0114; TIGR00893 634500008150 putative substrate translocation pore; other site 634500008151 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 634500008152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500008153 Cytochrome c; Region: Cytochrom_C; cl11414 634500008154 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 634500008155 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 634500008156 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500008157 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500008158 putative arabinose transporter; Provisional; Region: PRK03545 634500008159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008160 putative substrate translocation pore; other site 634500008161 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 634500008162 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 634500008163 Trp docking motif [polypeptide binding]; other site 634500008164 putative active site [active] 634500008165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500008166 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634500008167 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500008168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500008169 active site 634500008170 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 634500008171 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500008172 dimer interface [polypeptide binding]; other site 634500008173 ligand binding site [chemical binding]; other site 634500008174 HAMP domain; Region: HAMP; pfam00672 634500008175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500008176 dimer interface [polypeptide binding]; other site 634500008177 putative CheW interface [polypeptide binding]; other site 634500008178 Predicted transcriptional regulators [Transcription]; Region: COG1695 634500008179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 634500008180 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 634500008181 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 634500008182 FAD binding pocket [chemical binding]; other site 634500008183 FAD binding motif [chemical binding]; other site 634500008184 phosphate binding motif [ion binding]; other site 634500008185 NAD binding pocket [chemical binding]; other site 634500008186 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 634500008187 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 634500008188 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 634500008189 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 634500008190 NAD(P) binding site [chemical binding]; other site 634500008191 catalytic residues [active] 634500008192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500008193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500008194 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 634500008195 putative dimerization interface [polypeptide binding]; other site 634500008196 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 634500008197 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 634500008198 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 634500008199 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 634500008200 phosphoethanolamine transferase; Provisional; Region: PRK11560 634500008201 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 634500008202 Sulfatase; Region: Sulfatase; pfam00884 634500008203 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 634500008204 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 634500008205 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 634500008206 NAD(P) binding site [chemical binding]; other site 634500008207 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500008208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500008209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500008210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500008211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500008212 DNA binding site [nucleotide binding] 634500008213 domain linker motif; other site 634500008214 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500008215 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500008216 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 634500008217 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500008218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500008219 DNA binding site [nucleotide binding] 634500008220 domain linker motif; other site 634500008221 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 634500008222 putative ligand binding site [chemical binding]; other site 634500008223 Predicted membrane protein [Function unknown]; Region: COG2707 634500008224 salicylate hydroxylase; Provisional; Region: PRK08163 634500008225 hypothetical protein; Provisional; Region: PRK07236 634500008226 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 634500008227 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 634500008228 active site 634500008229 Zn binding site [ion binding]; other site 634500008230 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 634500008231 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 634500008232 XdhC Rossmann domain; Region: XdhC_C; pfam13478 634500008233 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 634500008234 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 634500008235 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 634500008236 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 634500008237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634500008238 catalytic loop [active] 634500008239 iron binding site [ion binding]; other site 634500008240 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 634500008241 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 634500008242 guanine deaminase; Provisional; Region: PRK09228 634500008243 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 634500008244 active site 634500008245 malonic semialdehyde reductase; Provisional; Region: PRK10538 634500008246 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 634500008247 putative NAD(P) binding site [chemical binding]; other site 634500008248 homodimer interface [polypeptide binding]; other site 634500008249 homotetramer interface [polypeptide binding]; other site 634500008250 active site 634500008251 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 634500008252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500008253 ATP binding site [chemical binding]; other site 634500008254 putative Mg++ binding site [ion binding]; other site 634500008255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500008256 nucleotide binding region [chemical binding]; other site 634500008257 ATP-binding site [chemical binding]; other site 634500008258 Helicase associated domain (HA2); Region: HA2; pfam04408 634500008259 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 634500008260 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 634500008261 azoreductase; Reviewed; Region: PRK00170 634500008262 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 634500008263 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 634500008264 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 634500008265 hypothetical protein; Provisional; Region: PRK10695 634500008266 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 634500008267 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634500008268 putative ligand binding site [chemical binding]; other site 634500008269 putative NAD binding site [chemical binding]; other site 634500008270 catalytic site [active] 634500008271 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 634500008272 Domain of unknown function (DUF333); Region: DUF333; pfam03891 634500008273 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 634500008274 MgtC family; Region: MgtC; pfam02308 634500008275 Uncharacterized conserved protein [Function unknown]; Region: COG1359 634500008276 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 634500008277 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634500008278 ATP binding site [chemical binding]; other site 634500008279 Mg++ binding site [ion binding]; other site 634500008280 motif III; other site 634500008281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500008282 nucleotide binding region [chemical binding]; other site 634500008283 ATP-binding site [chemical binding]; other site 634500008284 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 634500008285 putative RNA binding site [nucleotide binding]; other site 634500008286 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 634500008287 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 634500008288 Ligand Binding Site [chemical binding]; other site 634500008289 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 634500008290 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 634500008291 Cl binding site [ion binding]; other site 634500008292 oligomer interface [polypeptide binding]; other site 634500008293 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 634500008294 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 634500008295 peptide binding site [polypeptide binding]; other site 634500008296 murein peptide amidase A; Provisional; Region: PRK10602 634500008297 active site 634500008298 Zn binding site [ion binding]; other site 634500008299 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 634500008300 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 634500008301 active site 634500008302 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500008303 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500008304 Sensors of blue-light using FAD; Region: BLUF; smart01034 634500008305 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500008306 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 634500008307 dimer interface [polypeptide binding]; other site 634500008308 catalytic triad [active] 634500008309 peroxidatic and resolving cysteines [active] 634500008310 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 634500008311 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 634500008312 putative aromatic amino acid binding site; other site 634500008313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 634500008314 putative active site [active] 634500008315 heme pocket [chemical binding]; other site 634500008316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500008317 Walker A motif; other site 634500008318 ATP binding site [chemical binding]; other site 634500008319 Walker B motif; other site 634500008320 arginine finger; other site 634500008321 hypothetical protein; Provisional; Region: PRK05415 634500008322 Domain of unknown function (DUF697); Region: DUF697; cl12064 634500008323 Predicted ATPase [General function prediction only]; Region: COG3106 634500008324 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 634500008325 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 634500008326 phage shock protein C; Region: phageshock_pspC; TIGR02978 634500008327 phage shock protein B; Provisional; Region: pspB; PRK09458 634500008328 phage shock protein PspA; Provisional; Region: PRK10698 634500008329 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 634500008330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500008331 Walker A motif; other site 634500008332 ATP binding site [chemical binding]; other site 634500008333 Walker B motif; other site 634500008334 arginine finger; other site 634500008335 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 634500008336 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 634500008337 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 634500008338 peptide binding site [polypeptide binding]; other site 634500008339 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 634500008340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008341 dimer interface [polypeptide binding]; other site 634500008342 conserved gate region; other site 634500008343 putative PBP binding loops; other site 634500008344 ABC-ATPase subunit interface; other site 634500008345 cation transport regulator; Reviewed; Region: chaB; PRK09582 634500008346 putative phosphoketolase; Provisional; Region: PRK05261 634500008347 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 634500008348 TPP-binding site; other site 634500008349 XFP C-terminal domain; Region: XFP_C; pfam09363 634500008350 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 634500008351 dimer interface [polypeptide binding]; other site 634500008352 FMN binding site [chemical binding]; other site 634500008353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500008354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500008355 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 634500008356 putative effector binding pocket; other site 634500008357 putative dimerization interface [polypeptide binding]; other site 634500008358 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 634500008359 active site 1 [active] 634500008360 dimer interface [polypeptide binding]; other site 634500008361 hexamer interface [polypeptide binding]; other site 634500008362 active site 2 [active] 634500008363 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 634500008364 glutaredoxin 2; Provisional; Region: PRK10387 634500008365 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 634500008366 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 634500008367 N-terminal domain interface [polypeptide binding]; other site 634500008368 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 634500008369 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 634500008370 substrate binding site [chemical binding]; other site 634500008371 catalytic Zn binding site [ion binding]; other site 634500008372 NAD binding site [chemical binding]; other site 634500008373 structural Zn binding site [ion binding]; other site 634500008374 dimer interface [polypeptide binding]; other site 634500008375 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 634500008376 putative metal binding site [ion binding]; other site 634500008377 putative homodimer interface [polypeptide binding]; other site 634500008378 putative homotetramer interface [polypeptide binding]; other site 634500008379 putative homodimer-homodimer interface [polypeptide binding]; other site 634500008380 putative allosteric switch controlling residues; other site 634500008381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500008382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500008383 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500008384 putative effector binding pocket; other site 634500008385 putative dimerization interface [polypeptide binding]; other site 634500008386 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 634500008387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500008388 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500008389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008390 putative substrate translocation pore; other site 634500008391 Nitrate and nitrite sensing; Region: NIT; pfam08376 634500008392 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634500008393 HAMP domain; Region: HAMP; pfam00672 634500008394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500008395 dimer interface [polypeptide binding]; other site 634500008396 putative CheW interface [polypeptide binding]; other site 634500008397 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 634500008398 active site 634500008399 homotetramer interface [polypeptide binding]; other site 634500008400 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500008401 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500008402 Cytochrome c; Region: Cytochrom_C; pfam00034 634500008403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 634500008404 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 634500008405 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 634500008406 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 634500008407 tetrameric interface [polypeptide binding]; other site 634500008408 NAD binding site [chemical binding]; other site 634500008409 catalytic residues [active] 634500008410 substrate binding site [chemical binding]; other site 634500008411 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500008412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500008413 DNA-binding site [nucleotide binding]; DNA binding site 634500008414 FCD domain; Region: FCD; pfam07729 634500008415 Cache domain; Region: Cache_1; pfam02743 634500008416 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 634500008417 4-aminobutyrate transaminase; Provisional; Region: PRK09792 634500008418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500008419 inhibitor-cofactor binding pocket; inhibition site 634500008420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008421 catalytic residue [active] 634500008422 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500008423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500008424 DNA-binding site [nucleotide binding]; DNA binding site 634500008425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500008426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008427 homodimer interface [polypeptide binding]; other site 634500008428 catalytic residue [active] 634500008429 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 634500008430 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 634500008431 oligomer interface [polypeptide binding]; other site 634500008432 metal binding site [ion binding]; metal-binding site 634500008433 metal binding site [ion binding]; metal-binding site 634500008434 putative Cl binding site [ion binding]; other site 634500008435 basic sphincter; other site 634500008436 hydrophobic gate; other site 634500008437 periplasmic entrance; other site 634500008438 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 634500008439 dimanganese center [ion binding]; other site 634500008440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 634500008441 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 634500008442 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634500008443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008444 dimer interface [polypeptide binding]; other site 634500008445 conserved gate region; other site 634500008446 putative PBP binding loops; other site 634500008447 ABC-ATPase subunit interface; other site 634500008448 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 634500008449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500008450 Walker A/P-loop; other site 634500008451 ATP binding site [chemical binding]; other site 634500008452 Q-loop/lid; other site 634500008453 ABC transporter signature motif; other site 634500008454 Walker B; other site 634500008455 D-loop; other site 634500008456 H-loop/switch region; other site 634500008457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500008458 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 634500008459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500008460 Walker A/P-loop; other site 634500008461 ATP binding site [chemical binding]; other site 634500008462 Q-loop/lid; other site 634500008463 ABC transporter signature motif; other site 634500008464 Walker B; other site 634500008465 D-loop; other site 634500008466 H-loop/switch region; other site 634500008467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 634500008468 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 634500008469 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 634500008470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500008471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500008472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500008473 dimerization interface [polypeptide binding]; other site 634500008474 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 634500008475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500008476 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 634500008477 active site turn [active] 634500008478 phosphorylation site [posttranslational modification] 634500008479 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 634500008480 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 634500008481 putative molybdopterin cofactor binding site [chemical binding]; other site 634500008482 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 634500008483 putative molybdopterin cofactor binding site; other site 634500008484 exoribonuclease II; Provisional; Region: PRK05054 634500008485 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 634500008486 RNB domain; Region: RNB; pfam00773 634500008487 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 634500008488 carbon starvation protein A; Provisional; Region: PRK15015 634500008489 Carbon starvation protein CstA; Region: CstA; pfam02554 634500008490 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 634500008491 Uncharacterized small protein [Function unknown]; Region: COG2879 634500008492 RNase II stability modulator; Provisional; Region: PRK10060 634500008493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500008494 putative active site [active] 634500008495 heme pocket [chemical binding]; other site 634500008496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500008497 metal binding site [ion binding]; metal-binding site 634500008498 active site 634500008499 I-site; other site 634500008500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500008501 enoyl-CoA hydratase; Validated; Region: PRK08788 634500008502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634500008503 substrate binding site [chemical binding]; other site 634500008504 oxyanion hole (OAH) forming residues; other site 634500008505 trimer interface [polypeptide binding]; other site 634500008506 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 634500008507 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 634500008508 intersubunit interface [polypeptide binding]; other site 634500008509 active site 634500008510 Zn2+ binding site [ion binding]; other site 634500008511 lipoprotein; Provisional; Region: PRK10540 634500008512 translation initiation factor Sui1; Validated; Region: PRK06824 634500008513 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 634500008514 putative rRNA binding site [nucleotide binding]; other site 634500008515 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 634500008516 active site 634500008517 dimer interface [polypeptide binding]; other site 634500008518 tetratricopeptide repeat protein; Provisional; Region: PRK11788 634500008519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 634500008520 binding surface 634500008521 TPR motif; other site 634500008522 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 634500008523 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 634500008524 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 634500008525 active site 634500008526 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 634500008527 dimerization interface [polypeptide binding]; other site 634500008528 active site 634500008529 aconitate hydratase; Validated; Region: PRK09277 634500008530 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 634500008531 substrate binding site [chemical binding]; other site 634500008532 ligand binding site [chemical binding]; other site 634500008533 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 634500008534 substrate binding site [chemical binding]; other site 634500008535 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 634500008536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500008537 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 634500008538 substrate binding site [chemical binding]; other site 634500008539 putative dimerization interface [polypeptide binding]; other site 634500008540 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 634500008541 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 634500008542 active site 634500008543 interdomain interaction site; other site 634500008544 putative metal-binding site [ion binding]; other site 634500008545 nucleotide binding site [chemical binding]; other site 634500008546 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 634500008547 domain I; other site 634500008548 DNA binding groove [nucleotide binding] 634500008549 phosphate binding site [ion binding]; other site 634500008550 domain II; other site 634500008551 domain III; other site 634500008552 nucleotide binding site [chemical binding]; other site 634500008553 catalytic site [active] 634500008554 domain IV; other site 634500008555 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500008556 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500008557 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 634500008558 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 634500008559 hypothetical protein; Provisional; Region: PRK11037 634500008560 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 634500008561 putative inner membrane peptidase; Provisional; Region: PRK11778 634500008562 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 634500008563 tandem repeat interface [polypeptide binding]; other site 634500008564 oligomer interface [polypeptide binding]; other site 634500008565 active site residues [active] 634500008566 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 634500008567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500008568 NAD(P) binding site [chemical binding]; other site 634500008569 active site 634500008570 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 634500008571 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 634500008572 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 634500008573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500008574 RNA binding surface [nucleotide binding]; other site 634500008575 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 634500008576 probable active site [active] 634500008577 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634500008578 hypothetical protein; Provisional; Region: PRK11630 634500008579 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 634500008580 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 634500008581 active site 634500008582 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 634500008583 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 634500008584 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 634500008585 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 634500008586 Glutamine amidotransferase class-I; Region: GATase; pfam00117 634500008587 glutamine binding [chemical binding]; other site 634500008588 catalytic triad [active] 634500008589 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 634500008590 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 634500008591 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 634500008592 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 634500008593 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 634500008594 active site 634500008595 ribulose/triose binding site [chemical binding]; other site 634500008596 phosphate binding site [ion binding]; other site 634500008597 substrate (anthranilate) binding pocket [chemical binding]; other site 634500008598 product (indole) binding pocket [chemical binding]; other site 634500008599 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 634500008600 active site 634500008601 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 634500008602 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 634500008603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008604 catalytic residue [active] 634500008605 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 634500008606 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 634500008607 substrate binding site [chemical binding]; other site 634500008608 active site 634500008609 catalytic residues [active] 634500008610 heterodimer interface [polypeptide binding]; other site 634500008611 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 634500008612 BON domain; Region: BON; pfam04972 634500008613 outer membrane protein W; Provisional; Region: PRK10959 634500008614 hypothetical protein; Provisional; Region: PRK02868 634500008615 intracellular septation protein A; Reviewed; Region: PRK00259 634500008616 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 634500008617 transport protein TonB; Provisional; Region: PRK10819 634500008618 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 634500008619 YciI-like protein; Reviewed; Region: PRK11370 634500008620 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 634500008621 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 634500008622 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 634500008623 putative active site [active] 634500008624 catalytic site [active] 634500008625 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 634500008626 putative active site [active] 634500008627 catalytic site [active] 634500008628 dsDNA-mimic protein; Reviewed; Region: PRK05094 634500008629 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 634500008630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500008631 Walker A/P-loop; other site 634500008632 ATP binding site [chemical binding]; other site 634500008633 Q-loop/lid; other site 634500008634 ABC transporter signature motif; other site 634500008635 Walker B; other site 634500008636 D-loop; other site 634500008637 H-loop/switch region; other site 634500008638 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634500008639 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 634500008640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500008641 Walker A/P-loop; other site 634500008642 ATP binding site [chemical binding]; other site 634500008643 Q-loop/lid; other site 634500008644 ABC transporter signature motif; other site 634500008645 Walker B; other site 634500008646 D-loop; other site 634500008647 H-loop/switch region; other site 634500008648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500008649 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 634500008650 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634500008651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008652 dimer interface [polypeptide binding]; other site 634500008653 conserved gate region; other site 634500008654 ABC-ATPase subunit interface; other site 634500008655 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 634500008656 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 634500008657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500008658 dimer interface [polypeptide binding]; other site 634500008659 conserved gate region; other site 634500008660 putative PBP binding loops; other site 634500008661 ABC-ATPase subunit interface; other site 634500008662 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 634500008663 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 634500008664 peptide binding site [polypeptide binding]; other site 634500008665 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 634500008666 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 634500008667 peptide binding site [polypeptide binding]; other site 634500008668 hypothetical protein; Provisional; Region: PRK11111 634500008669 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 634500008670 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 634500008671 putative catalytic cysteine [active] 634500008672 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 634500008673 putative active site [active] 634500008674 metal binding site [ion binding]; metal-binding site 634500008675 thymidine kinase; Provisional; Region: PRK04296 634500008676 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 634500008677 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 634500008678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634500008679 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 634500008680 putative NAD(P) binding site [chemical binding]; other site 634500008681 active site 634500008682 putative substrate binding site [chemical binding]; other site 634500008683 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 634500008684 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 634500008685 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 634500008686 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 634500008687 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 634500008688 active site 634500008689 tetramer interface; other site 634500008690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500008691 active site 634500008692 response regulator of RpoS; Provisional; Region: PRK10693 634500008693 phosphorylation site [posttranslational modification] 634500008694 intermolecular recognition site; other site 634500008695 dimerization interface [polypeptide binding]; other site 634500008696 hypothetical protein; Provisional; Region: PRK10279 634500008697 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 634500008698 active site 634500008699 nucleophile elbow; other site 634500008700 SEC-C motif; Region: SEC-C; pfam02810 634500008701 hypothetical protein; Provisional; Region: PRK01842 634500008702 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 634500008703 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 634500008704 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 634500008705 putative active site [active] 634500008706 putative substrate binding site [chemical binding]; other site 634500008707 putative cosubstrate binding site; other site 634500008708 catalytic site [active] 634500008709 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 634500008710 putative catalytic site [active] 634500008711 putative phosphate binding site [ion binding]; other site 634500008712 active site 634500008713 metal binding site A [ion binding]; metal-binding site 634500008714 DNA binding site [nucleotide binding] 634500008715 putative AP binding site [nucleotide binding]; other site 634500008716 putative metal binding site B [ion binding]; other site 634500008717 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 634500008718 DNA topoisomerase III; Provisional; Region: PRK07726 634500008719 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 634500008720 active site 634500008721 putative interdomain interaction site [polypeptide binding]; other site 634500008722 putative metal-binding site [ion binding]; other site 634500008723 putative nucleotide binding site [chemical binding]; other site 634500008724 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 634500008725 domain I; other site 634500008726 DNA binding groove [nucleotide binding] 634500008727 phosphate binding site [ion binding]; other site 634500008728 domain II; other site 634500008729 domain III; other site 634500008730 nucleotide binding site [chemical binding]; other site 634500008731 catalytic site [active] 634500008732 domain IV; other site 634500008733 selenophosphate synthetase; Provisional; Region: PRK00943 634500008734 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 634500008735 dimerization interface [polypeptide binding]; other site 634500008736 putative ATP binding site [chemical binding]; other site 634500008737 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 634500008738 putative FMN binding site [chemical binding]; other site 634500008739 protease 4; Provisional; Region: PRK10949 634500008740 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 634500008741 tandem repeat interface [polypeptide binding]; other site 634500008742 oligomer interface [polypeptide binding]; other site 634500008743 active site residues [active] 634500008744 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 634500008745 tandem repeat interface [polypeptide binding]; other site 634500008746 oligomer interface [polypeptide binding]; other site 634500008747 active site residues [active] 634500008748 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 634500008749 active site 634500008750 homodimer interface [polypeptide binding]; other site 634500008751 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 634500008752 Isochorismatase family; Region: Isochorismatase; pfam00857 634500008753 catalytic triad [active] 634500008754 metal binding site [ion binding]; metal-binding site 634500008755 conserved cis-peptide bond; other site 634500008756 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 634500008757 methionine sulfoxide reductase B; Provisional; Region: PRK00222 634500008758 SelR domain; Region: SelR; pfam01641 634500008759 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 634500008760 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 634500008761 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 634500008762 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 634500008763 active site 634500008764 phosphate binding residues; other site 634500008765 catalytic residues [active] 634500008766 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500008767 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500008768 active site 634500008769 catalytic tetrad [active] 634500008770 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 634500008771 PrkA family serine protein kinase; Provisional; Region: PRK15455 634500008772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500008773 Walker A motif; other site 634500008774 ATP binding site [chemical binding]; other site 634500008775 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 634500008776 hypothetical protein; Provisional; Region: PRK05325 634500008777 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 634500008778 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 634500008779 TrkA-C domain; Region: TrkA_C; pfam02080 634500008780 Transporter associated domain; Region: CorC_HlyC; smart01091 634500008781 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 634500008782 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 634500008783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 634500008784 Bacterial sugar transferase; Region: Bac_transf; pfam02397 634500008785 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 634500008786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008787 putative substrate translocation pore; other site 634500008788 alanine racemase; Reviewed; Region: dadX; PRK03646 634500008789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 634500008790 active site 634500008791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634500008792 substrate binding site [chemical binding]; other site 634500008793 catalytic residues [active] 634500008794 dimer interface [polypeptide binding]; other site 634500008795 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 634500008796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500008797 SpoVR family protein; Provisional; Region: PRK11767 634500008798 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 634500008799 fatty acid metabolism regulator; Provisional; Region: PRK04984 634500008800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500008801 DNA-binding site [nucleotide binding]; DNA binding site 634500008802 FadR C-terminal domain; Region: FadR_C; pfam07840 634500008803 disulfide bond formation protein B; Provisional; Region: PRK01749 634500008804 hypothetical protein; Provisional; Region: PRK05170 634500008805 hypothetical protein; Provisional; Region: PRK10691 634500008806 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 634500008807 Transglycosylase SLT domain; Region: SLT_2; pfam13406 634500008808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500008809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500008810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 634500008811 septum formation inhibitor; Reviewed; Region: minC; PRK03511 634500008812 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 634500008813 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 634500008814 cell division inhibitor MinD; Provisional; Region: PRK10818 634500008815 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 634500008816 Switch I; other site 634500008817 Switch II; other site 634500008818 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 634500008819 ribonuclease D; Provisional; Region: PRK10829 634500008820 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 634500008821 catalytic site [active] 634500008822 putative active site [active] 634500008823 putative substrate binding site [chemical binding]; other site 634500008824 HRDC domain; Region: HRDC; cl02578 634500008825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 634500008826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 634500008827 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 634500008828 acyl-activating enzyme (AAE) consensus motif; other site 634500008829 putative AMP binding site [chemical binding]; other site 634500008830 putative active site [active] 634500008831 putative CoA binding site [chemical binding]; other site 634500008832 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 634500008833 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 634500008834 Glycoprotease family; Region: Peptidase_M22; pfam00814 634500008835 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 634500008836 DEAD/DEAH box helicase; Region: DEAD; pfam00270 634500008837 ATP binding site [chemical binding]; other site 634500008838 DEAD_2; Region: DEAD_2; pfam06733 634500008839 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 634500008840 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 634500008841 homotrimer interaction site [polypeptide binding]; other site 634500008842 putative active site [active] 634500008843 hypothetical protein; Provisional; Region: PRK05114 634500008844 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 634500008845 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 634500008846 chorismate binding enzyme; Region: Chorismate_bind; cl10555 634500008847 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 634500008848 putative active site [active] 634500008849 putative CoA binding site [chemical binding]; other site 634500008850 nudix motif; other site 634500008851 metal binding site [ion binding]; metal-binding site 634500008852 L-serine deaminase; Provisional; Region: PRK15023 634500008853 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 634500008854 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 634500008855 phage resistance protein; Provisional; Region: PRK10551 634500008856 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 634500008857 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500008858 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 634500008859 gliding motility-associated protein GldE; Region: GldE; TIGR03520 634500008860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634500008861 Transporter associated domain; Region: CorC_HlyC; smart01091 634500008862 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 634500008863 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 634500008864 active pocket/dimerization site; other site 634500008865 active site 634500008866 phosphorylation site [posttranslational modification] 634500008867 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 634500008868 active site 634500008869 phosphorylation site [posttranslational modification] 634500008870 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 634500008871 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 634500008872 hypothetical protein; Provisional; Region: PRK02913 634500008873 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 634500008874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500008875 S-adenosylmethionine binding site [chemical binding]; other site 634500008876 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500008877 DNA-binding site [nucleotide binding]; DNA binding site 634500008878 RNA-binding motif; other site 634500008879 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 634500008880 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 634500008881 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 634500008882 YebO-like protein; Region: YebO; pfam13974 634500008883 YobH-like protein; Region: YobH; pfam13996 634500008884 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 634500008885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500008886 dimerization interface [polypeptide binding]; other site 634500008887 putative Zn2+ binding site [ion binding]; other site 634500008888 putative DNA binding site [nucleotide binding]; other site 634500008889 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500008890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500008892 putative substrate translocation pore; other site 634500008893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008894 heat shock protein HtpX; Provisional; Region: PRK05457 634500008895 carboxy-terminal protease; Provisional; Region: PRK11186 634500008896 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 634500008897 protein binding site [polypeptide binding]; other site 634500008898 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 634500008899 Catalytic dyad [active] 634500008900 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 634500008901 ProP expression regulator; Provisional; Region: PRK04950 634500008902 ProQ/FINO family; Region: ProQ; pfam04352 634500008903 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 634500008904 GAF domain; Region: GAF_2; pfam13185 634500008905 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 634500008906 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500008907 Paraquat-inducible protein A; Region: PqiA; pfam04403 634500008908 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 634500008909 mce related protein; Region: MCE; pfam02470 634500008910 mce related protein; Region: MCE; pfam02470 634500008911 mce related protein; Region: MCE; pfam02470 634500008912 mce related protein; Region: MCE; pfam02470 634500008913 mce related protein; Region: MCE; pfam02470 634500008914 mce related protein; Region: MCE; pfam02470 634500008915 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 634500008916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500008917 S-adenosylmethionine binding site [chemical binding]; other site 634500008918 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 634500008919 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 634500008920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500008921 active site 634500008922 metal binding site [ion binding]; metal-binding site 634500008923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634500008924 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 634500008925 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 634500008926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500008927 catalytic residue [active] 634500008928 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 634500008929 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 634500008930 CopC domain; Region: CopC; cl01012 634500008931 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 634500008932 Predicted amidohydrolase [General function prediction only]; Region: COG0388 634500008933 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 634500008934 active site 634500008935 catalytic triad [active] 634500008936 dimer interface [polypeptide binding]; other site 634500008937 exodeoxyribonuclease X; Provisional; Region: PRK07983 634500008938 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 634500008939 active site 634500008940 catalytic site [active] 634500008941 substrate binding site [chemical binding]; other site 634500008942 protease 2; Provisional; Region: PRK10115 634500008943 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500008944 Protein of unknown function (DUF533); Region: DUF533; pfam04391 634500008945 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 634500008946 putative metal binding site [ion binding]; other site 634500008947 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500008948 YebG protein; Region: YebG; pfam07130 634500008949 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 634500008950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500008951 ATP-grasp domain; Region: ATP-grasp; pfam02222 634500008952 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 634500008953 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 634500008954 active site 634500008955 intersubunit interface [polypeptide binding]; other site 634500008956 catalytic residue [active] 634500008957 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 634500008958 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 634500008959 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 634500008960 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 634500008961 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500008962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500008963 putative active site [active] 634500008964 pyruvate kinase; Provisional; Region: PRK05826 634500008965 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 634500008966 domain interfaces; other site 634500008967 active site 634500008968 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 634500008969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500008970 catalytic residue [active] 634500008971 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 634500008972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500008973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 634500008974 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 634500008975 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 634500008976 IucA / IucC family; Region: IucA_IucC; pfam04183 634500008977 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 634500008978 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 634500008979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500008980 putative substrate translocation pore; other site 634500008981 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 634500008982 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 634500008983 putative acyl-acceptor binding pocket; other site 634500008984 putative peptidase; Provisional; Region: PRK11649 634500008985 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 634500008986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500008987 Peptidase family M23; Region: Peptidase_M23; pfam01551 634500008988 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 634500008989 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 634500008990 metal binding site [ion binding]; metal-binding site 634500008991 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 634500008992 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 634500008993 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 634500008994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500008995 ABC-ATPase subunit interface; other site 634500008996 dimer interface [polypeptide binding]; other site 634500008997 putative PBP binding regions; other site 634500008998 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 634500008999 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 634500009000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500009001 Walker A motif; other site 634500009002 ATP binding site [chemical binding]; other site 634500009003 Walker B motif; other site 634500009004 arginine finger; other site 634500009005 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 634500009006 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 634500009007 RuvA N terminal domain; Region: RuvA_N; pfam01330 634500009008 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 634500009009 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 634500009010 active site 634500009011 putative DNA-binding cleft [nucleotide binding]; other site 634500009012 dimer interface [polypeptide binding]; other site 634500009013 hypothetical protein; Validated; Region: PRK00110 634500009014 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 634500009015 nudix motif; other site 634500009016 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 634500009017 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 634500009018 dimer interface [polypeptide binding]; other site 634500009019 anticodon binding site; other site 634500009020 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 634500009021 homodimer interface [polypeptide binding]; other site 634500009022 motif 1; other site 634500009023 active site 634500009024 motif 2; other site 634500009025 GAD domain; Region: GAD; pfam02938 634500009026 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 634500009027 active site 634500009028 motif 3; other site 634500009029 Isochorismatase family; Region: Isochorismatase; pfam00857 634500009030 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 634500009031 catalytic triad [active] 634500009032 conserved cis-peptide bond; other site 634500009033 hypothetical protein; Provisional; Region: PRK10302 634500009034 MAPEG family; Region: MAPEG; cl09190 634500009035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500009036 S-adenosylmethionine binding site [chemical binding]; other site 634500009037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 634500009038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500009039 S-adenosylmethionine binding site [chemical binding]; other site 634500009040 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634500009041 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634500009042 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 634500009043 dimer interface [polypeptide binding]; other site 634500009044 active site 634500009045 metal binding site [ion binding]; metal-binding site 634500009046 copper homeostasis protein CutC; Provisional; Region: PRK11572 634500009047 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 634500009048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500009049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500009050 homodimer interface [polypeptide binding]; other site 634500009051 catalytic residue [active] 634500009052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 634500009053 putative metal binding site [ion binding]; other site 634500009054 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 634500009055 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 634500009056 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 634500009057 active site 634500009058 HIGH motif; other site 634500009059 KMSK motif region; other site 634500009060 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 634500009061 tRNA binding surface [nucleotide binding]; other site 634500009062 anticodon binding site; other site 634500009063 Flagellar protein FlhE; Region: FlhE; pfam06366 634500009064 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 634500009065 FHIPEP family; Region: FHIPEP; pfam00771 634500009066 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 634500009067 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 634500009068 chemotaxis regulator CheZ; Provisional; Region: PRK11166 634500009069 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 634500009070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500009071 active site 634500009072 phosphorylation site [posttranslational modification] 634500009073 intermolecular recognition site; other site 634500009074 dimerization interface [polypeptide binding]; other site 634500009075 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 634500009076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500009077 active site 634500009078 phosphorylation site [posttranslational modification] 634500009079 intermolecular recognition site; other site 634500009080 dimerization interface [polypeptide binding]; other site 634500009081 CheB methylesterase; Region: CheB_methylest; pfam01339 634500009082 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 634500009083 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 634500009084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500009085 S-adenosylmethionine binding site [chemical binding]; other site 634500009086 methyl-accepting protein IV; Provisional; Region: PRK09793 634500009087 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500009088 dimer interface [polypeptide binding]; other site 634500009089 ligand binding site [chemical binding]; other site 634500009090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500009091 dimerization interface [polypeptide binding]; other site 634500009092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500009093 dimer interface [polypeptide binding]; other site 634500009094 putative CheW interface [polypeptide binding]; other site 634500009095 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 634500009096 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500009097 dimer interface [polypeptide binding]; other site 634500009098 ligand binding site [chemical binding]; other site 634500009099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500009100 dimerization interface [polypeptide binding]; other site 634500009101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500009102 dimer interface [polypeptide binding]; other site 634500009103 putative CheW interface [polypeptide binding]; other site 634500009104 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 634500009105 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500009106 dimer interface [polypeptide binding]; other site 634500009107 ligand binding site [chemical binding]; other site 634500009108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500009109 dimerization interface [polypeptide binding]; other site 634500009110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500009111 dimer interface [polypeptide binding]; other site 634500009112 putative CheW interface [polypeptide binding]; other site 634500009113 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 634500009114 putative CheA interaction surface; other site 634500009115 chemotaxis protein CheA; Provisional; Region: PRK10547 634500009116 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634500009117 putative binding surface; other site 634500009118 active site 634500009119 CheY binding; Region: CheY-binding; pfam09078 634500009120 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 634500009121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500009122 ATP binding site [chemical binding]; other site 634500009123 Mg2+ binding site [ion binding]; other site 634500009124 G-X-G motif; other site 634500009125 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 634500009126 flagellar motor protein MotB; Validated; Region: motB; PRK09041 634500009127 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 634500009128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500009129 ligand binding site [chemical binding]; other site 634500009130 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 634500009131 flagellar motor protein MotA; Validated; Region: PRK09110 634500009132 transcriptional activator FlhC; Provisional; Region: PRK12722 634500009133 transcriptional activator FlhD; Provisional; Region: PRK02909 634500009134 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 634500009135 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 634500009136 active site 634500009137 homotetramer interface [polypeptide binding]; other site 634500009138 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 634500009139 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 634500009140 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 634500009141 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 634500009142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500009143 Zn2+ binding site [ion binding]; other site 634500009144 Mg2+ binding site [ion binding]; other site 634500009145 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 634500009146 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500009147 Catalytic site [active] 634500009148 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 634500009149 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 634500009150 dimerization interface [polypeptide binding]; other site 634500009151 NAD binding site [chemical binding]; other site 634500009152 ligand binding site [chemical binding]; other site 634500009153 catalytic site [active] 634500009154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 634500009157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009160 putative substrate translocation pore; other site 634500009161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500009162 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500009163 active site 634500009164 catalytic tetrad [active] 634500009165 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500009166 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500009167 active site 634500009168 catalytic tetrad [active] 634500009169 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 634500009170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500009171 catalytic site [active] 634500009172 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 634500009173 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 634500009174 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 634500009175 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 634500009176 HAMP domain; Region: HAMP; pfam00672 634500009177 dimerization interface [polypeptide binding]; other site 634500009178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500009179 dimer interface [polypeptide binding]; other site 634500009180 phosphorylation site [posttranslational modification] 634500009181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500009182 ATP binding site [chemical binding]; other site 634500009183 Mg2+ binding site [ion binding]; other site 634500009184 G-X-G motif; other site 634500009185 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 634500009186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500009187 active site 634500009188 phosphorylation site [posttranslational modification] 634500009189 intermolecular recognition site; other site 634500009190 dimerization interface [polypeptide binding]; other site 634500009191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500009192 DNA binding site [nucleotide binding] 634500009193 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 634500009194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009195 putative substrate translocation pore; other site 634500009196 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 634500009197 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 634500009198 XdhC Rossmann domain; Region: XdhC_C; pfam13478 634500009199 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 634500009200 metal-binding site 634500009201 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500009202 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500009203 Cytochrome c; Region: Cytochrom_C; pfam00034 634500009204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 634500009205 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 634500009206 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 634500009207 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 634500009208 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 634500009209 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 634500009210 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 634500009211 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 634500009212 TLC ATP/ADP transporter; Region: TLC; cl03940 634500009213 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 634500009214 NADH(P)-binding; Region: NAD_binding_10; pfam13460 634500009215 NAD(P) binding site [chemical binding]; other site 634500009216 putative active site [active] 634500009217 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 634500009218 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 634500009219 Protein export membrane protein; Region: SecD_SecF; cl14618 634500009220 Protein export membrane protein; Region: SecD_SecF; cl14618 634500009221 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 634500009222 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500009223 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500009224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009226 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500009227 putative effector binding pocket; other site 634500009228 putative dimerization interface [polypeptide binding]; other site 634500009229 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 634500009230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 634500009231 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500009232 active site 634500009233 metal binding site [ion binding]; metal-binding site 634500009234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500009235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009236 dimer interface [polypeptide binding]; other site 634500009237 conserved gate region; other site 634500009238 putative PBP binding loops; other site 634500009239 ABC-ATPase subunit interface; other site 634500009240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009241 dimer interface [polypeptide binding]; other site 634500009242 conserved gate region; other site 634500009243 putative PBP binding loops; other site 634500009244 ABC-ATPase subunit interface; other site 634500009245 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500009246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634500009247 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 634500009248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500009249 Walker A/P-loop; other site 634500009250 ATP binding site [chemical binding]; other site 634500009251 Q-loop/lid; other site 634500009252 ABC transporter signature motif; other site 634500009253 Walker B; other site 634500009254 D-loop; other site 634500009255 H-loop/switch region; other site 634500009256 TOBE domain; Region: TOBE_2; pfam08402 634500009257 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 634500009258 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 634500009259 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 634500009260 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 634500009261 hypothetical protein; Provisional; Region: PRK09272 634500009262 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 634500009263 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 634500009264 putative NAD(P) binding site [chemical binding]; other site 634500009265 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500009266 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634500009267 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 634500009268 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 634500009269 putative active site [active] 634500009270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 634500009271 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 634500009272 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 634500009273 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500009274 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 634500009275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500009276 NAD(P) binding site [chemical binding]; other site 634500009277 active site 634500009278 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 634500009279 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 634500009280 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 634500009281 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 634500009282 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 634500009283 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 634500009284 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 634500009285 active site 634500009286 DNA binding site [nucleotide binding] 634500009287 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 634500009288 Autotransporter beta-domain; Region: Autotransporter; pfam03797 634500009289 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 634500009290 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 634500009291 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 634500009292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500009293 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 634500009294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500009295 motif II; other site 634500009296 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 634500009297 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 634500009298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009300 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 634500009301 substrate binding pocket [chemical binding]; other site 634500009302 dimerization interface [polypeptide binding]; other site 634500009303 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 634500009304 HPP family; Region: HPP; pfam04982 634500009305 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 634500009306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 634500009307 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 634500009308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009310 EthD domain; Region: EthD; cl17553 634500009311 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 634500009312 dimer interface [polypeptide binding]; other site 634500009313 active site 634500009314 Schiff base residues; other site 634500009315 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 634500009316 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634500009317 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 634500009318 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500009319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500009320 active site 634500009321 CHASE4 domain; Region: CHASE4; pfam05228 634500009322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500009323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500009324 metal binding site [ion binding]; metal-binding site 634500009325 active site 634500009326 I-site; other site 634500009327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500009328 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 634500009329 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 634500009330 Na binding site [ion binding]; other site 634500009331 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 634500009332 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634500009333 NAD(P) binding site [chemical binding]; other site 634500009334 catalytic residues [active] 634500009335 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 634500009336 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 634500009337 catalytic triad [active] 634500009338 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 634500009339 EamA-like transporter family; Region: EamA; pfam00892 634500009340 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 634500009341 CoA-transferase family III; Region: CoA_transf_3; pfam02515 634500009342 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 634500009343 putative hydrolase; Validated; Region: PRK09248 634500009344 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 634500009345 active site 634500009346 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 634500009347 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 634500009348 putative ligand binding site [chemical binding]; other site 634500009349 NAD binding site [chemical binding]; other site 634500009350 dimerization interface [polypeptide binding]; other site 634500009351 catalytic site [active] 634500009352 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 634500009353 alkaline phosphatase; Provisional; Region: PRK10518 634500009354 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 634500009355 dimer interface [polypeptide binding]; other site 634500009356 active site 634500009357 hypothetical protein; Provisional; Region: PRK10536 634500009358 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 634500009359 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 634500009360 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 634500009361 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 634500009362 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 634500009363 Imelysin; Region: Peptidase_M75; pfam09375 634500009364 Iron permease FTR1 family; Region: FTR1; cl00475 634500009365 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 634500009366 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 634500009367 Na binding site [ion binding]; other site 634500009368 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 634500009369 Predicted transcriptional regulator [Transcription]; Region: COG3905 634500009370 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 634500009371 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 634500009372 Glutamate binding site [chemical binding]; other site 634500009373 NAD binding site [chemical binding]; other site 634500009374 catalytic residues [active] 634500009375 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500009376 Predicted membrane protein [Function unknown]; Region: COG4763 634500009377 Predicted membrane protein [Function unknown]; Region: COG4763 634500009378 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500009379 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 634500009380 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500009381 Walker A/P-loop; other site 634500009382 ATP binding site [chemical binding]; other site 634500009383 Q-loop/lid; other site 634500009384 ABC transporter signature motif; other site 634500009385 Walker B; other site 634500009386 D-loop; other site 634500009387 H-loop/switch region; other site 634500009388 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500009389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009390 dimer interface [polypeptide binding]; other site 634500009391 conserved gate region; other site 634500009392 putative PBP binding loops; other site 634500009393 ABC-ATPase subunit interface; other site 634500009394 cystine transporter subunit; Provisional; Region: PRK11260 634500009395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500009396 substrate binding pocket [chemical binding]; other site 634500009397 membrane-bound complex binding site; other site 634500009398 hinge residues; other site 634500009399 D-cysteine desulfhydrase; Validated; Region: PRK03910 634500009400 pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family; Region: ACC_deam_rel; TIGR01275 634500009401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500009402 catalytic residue [active] 634500009403 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 634500009404 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 634500009405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500009406 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634500009407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500009408 DNA binding residues [nucleotide binding] 634500009409 HNH endonuclease; Region: HNH_2; pfam13391 634500009410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 634500009411 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500009412 active site 634500009413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 634500009414 active site 634500009415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 634500009416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 634500009417 active site 634500009418 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 634500009419 flagellin; Validated; Region: PRK06819 634500009420 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 634500009421 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 634500009422 flagellar capping protein; Reviewed; Region: fliD; PRK08032 634500009423 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 634500009424 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 634500009425 flagellar protein FliS; Validated; Region: fliS; PRK05685 634500009426 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 634500009427 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 634500009428 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 634500009429 active site 634500009430 Na/Ca binding site [ion binding]; other site 634500009431 catalytic site [active] 634500009432 lipoprotein; Provisional; Region: PRK10397 634500009433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500009434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500009435 metal binding site [ion binding]; metal-binding site 634500009436 active site 634500009437 I-site; other site 634500009438 Probable polygalacturonase; Region: PLN02793 634500009439 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 634500009440 catalytic residue [active] 634500009441 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 634500009442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500009443 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500009444 sequence-specific DNA binding site [nucleotide binding]; other site 634500009445 salt bridge; other site 634500009446 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500009447 Catalytic site [active] 634500009448 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 634500009449 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 634500009450 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 634500009451 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 634500009452 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 634500009453 FliG C-terminal domain; Region: FliG_C; pfam01706 634500009454 flagellar assembly protein H; Validated; Region: fliH; PRK05687 634500009455 Flagellar assembly protein FliH; Region: FliH; pfam02108 634500009456 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 634500009457 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 634500009458 Walker A motif/ATP binding site; other site 634500009459 Walker B motif; other site 634500009460 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 634500009461 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 634500009462 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 634500009463 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 634500009464 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 634500009465 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 634500009466 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 634500009467 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 634500009468 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 634500009469 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 634500009470 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 634500009471 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 634500009472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500009473 DNA binding residues [nucleotide binding] 634500009474 dimerization interface [polypeptide binding]; other site 634500009475 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500009476 dimer interface [polypeptide binding]; other site 634500009477 ligand binding site [chemical binding]; other site 634500009478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500009479 dimerization interface [polypeptide binding]; other site 634500009480 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500009481 dimer interface [polypeptide binding]; other site 634500009482 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 634500009483 putative CheW interface [polypeptide binding]; other site 634500009484 hypothetical protein; Provisional; Region: PRK10708 634500009485 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 634500009486 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 634500009487 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 634500009488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500009489 active site 634500009490 motif I; other site 634500009491 motif II; other site 634500009492 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 634500009493 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 634500009494 hypothetical protein; Provisional; Region: PRK10062 634500009495 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 634500009496 EamA-like transporter family; Region: EamA; pfam00892 634500009497 EamA-like transporter family; Region: EamA; pfam00892 634500009498 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 634500009499 additional DNA contacts [nucleotide binding]; other site 634500009500 mismatch recognition site; other site 634500009501 active site 634500009502 zinc binding site [ion binding]; other site 634500009503 DNA intercalation site [nucleotide binding]; other site 634500009504 DNA cytosine methylase; Provisional; Region: PRK10458 634500009505 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 634500009506 cofactor binding site; other site 634500009507 DNA binding site [nucleotide binding] 634500009508 substrate interaction site [chemical binding]; other site 634500009509 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 634500009510 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500009511 Zn2+ binding site [ion binding]; other site 634500009512 Mg2+ binding site [ion binding]; other site 634500009513 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 634500009514 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 634500009515 Helix-turn-helix domain; Region: HTH_38; pfam13936 634500009516 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 634500009517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500009518 Zn2+ binding site [ion binding]; other site 634500009519 Mg2+ binding site [ion binding]; other site 634500009520 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 634500009521 Part of AAA domain; Region: AAA_19; pfam13245 634500009522 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 634500009523 AAA domain; Region: AAA_12; pfam13087 634500009524 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 634500009525 putative active site [active] 634500009526 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 634500009527 Transposase; Region: HTH_Tnp_1; pfam01527 634500009528 Integrase core domain; Region: rve; pfam00665 634500009529 Integrase core domain; Region: rve_3; pfam13683 634500009530 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 634500009531 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500009532 DNA-binding site [nucleotide binding]; DNA binding site 634500009533 RNA-binding motif; other site 634500009534 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634500009535 active site 634500009536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 634500009537 Protein of unknown function (DUF796); Region: DUF796; pfam05638 634500009538 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 634500009539 active site 634500009540 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 634500009541 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 634500009542 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 634500009543 substrate binding site [chemical binding]; other site 634500009544 THF binding site; other site 634500009545 zinc-binding site [ion binding]; other site 634500009546 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 634500009547 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 634500009548 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 634500009549 amidohydrolase; Provisional; Region: PRK12393 634500009550 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 634500009551 active site 634500009552 putative substrate binding pocket [chemical binding]; other site 634500009553 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634500009554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500009557 dimerization interface [polypeptide binding]; other site 634500009558 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 634500009559 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 634500009560 FMN-binding pocket [chemical binding]; other site 634500009561 flavin binding motif; other site 634500009562 phosphate binding motif [ion binding]; other site 634500009563 beta-alpha-beta structure motif; other site 634500009564 NAD binding pocket [chemical binding]; other site 634500009565 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634500009566 catalytic loop [active] 634500009567 iron binding site [ion binding]; other site 634500009568 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 634500009569 cytosine deaminase-like protein; Validated; Region: PRK07583 634500009570 active site 634500009571 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500009572 homotrimer interaction site [polypeptide binding]; other site 634500009573 putative active site [active] 634500009574 Creatinine amidohydrolase; Region: Creatininase; pfam02633 634500009575 NMT1/THI5 like; Region: NMT1; pfam09084 634500009576 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 634500009577 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634500009578 Walker A/P-loop; other site 634500009579 ATP binding site [chemical binding]; other site 634500009580 Q-loop/lid; other site 634500009581 ABC transporter signature motif; other site 634500009582 Walker B; other site 634500009583 D-loop; other site 634500009584 H-loop/switch region; other site 634500009585 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634500009586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009587 dimer interface [polypeptide binding]; other site 634500009588 conserved gate region; other site 634500009589 putative PBP binding loops; other site 634500009590 ABC-ATPase subunit interface; other site 634500009591 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 634500009592 FAD binding domain; Region: FAD_binding_4; pfam01565 634500009593 outer membrane porin, OprD family; Region: OprD; pfam03573 634500009594 Putative transcription activator [Transcription]; Region: TenA; COG0819 634500009595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500009596 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 634500009597 Walker A/P-loop; other site 634500009598 ATP binding site [chemical binding]; other site 634500009599 Q-loop/lid; other site 634500009600 ABC transporter signature motif; other site 634500009601 Walker B; other site 634500009602 D-loop; other site 634500009603 H-loop/switch region; other site 634500009604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634500009605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009606 dimer interface [polypeptide binding]; other site 634500009607 conserved gate region; other site 634500009608 putative PBP binding loops; other site 634500009609 ABC-ATPase subunit interface; other site 634500009610 NMT1/THI5 like; Region: NMT1; pfam09084 634500009611 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 634500009612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009614 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 634500009615 FAD binding domain; Region: FAD_binding_4; pfam01565 634500009616 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 634500009617 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 634500009618 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 634500009619 substrate binding site; other site 634500009620 Manganese binding site; other site 634500009621 dimer interface; other site 634500009622 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 634500009623 catalytic residues [active] 634500009624 dimer interface [polypeptide binding]; other site 634500009625 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 634500009626 NmrA-like family; Region: NmrA; pfam05368 634500009627 NAD(P) binding site [chemical binding]; other site 634500009628 active site lysine 634500009629 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500009630 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634500009631 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 634500009632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500009634 putative substrate translocation pore; other site 634500009635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500009636 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 634500009637 active site 634500009638 Mn binding site [ion binding]; other site 634500009639 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634500009640 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 634500009641 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 634500009642 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 634500009643 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 634500009644 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 634500009645 TMP-binding site; other site 634500009646 ATP-binding site [chemical binding]; other site 634500009647 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500009648 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634500009649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500009651 putative substrate translocation pore; other site 634500009652 EamA-like transporter family; Region: EamA; pfam00892 634500009653 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 634500009654 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009656 putative substrate translocation pore; other site 634500009657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009659 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 634500009660 putative effector binding pocket; other site 634500009661 putative dimerization interface [polypeptide binding]; other site 634500009662 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 634500009663 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 634500009664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009665 dimer interface [polypeptide binding]; other site 634500009666 conserved gate region; other site 634500009667 putative PBP binding loops; other site 634500009668 ABC-ATPase subunit interface; other site 634500009669 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 634500009670 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 634500009671 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 634500009672 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 634500009673 Walker A/P-loop; other site 634500009674 ATP binding site [chemical binding]; other site 634500009675 Q-loop/lid; other site 634500009676 ABC transporter signature motif; other site 634500009677 Walker B; other site 634500009678 D-loop; other site 634500009679 H-loop/switch region; other site 634500009680 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 634500009681 AAA domain; Region: AAA_33; pfam13671 634500009682 active site 634500009683 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 634500009684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500009685 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 634500009686 active site 634500009687 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 634500009688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500009689 Walker A/P-loop; other site 634500009690 ATP binding site [chemical binding]; other site 634500009691 Q-loop/lid; other site 634500009692 ABC transporter signature motif; other site 634500009693 Walker B; other site 634500009694 D-loop; other site 634500009695 H-loop/switch region; other site 634500009696 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 634500009697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500009698 Walker A/P-loop; other site 634500009699 ATP binding site [chemical binding]; other site 634500009700 Q-loop/lid; other site 634500009701 ABC transporter signature motif; other site 634500009702 Walker B; other site 634500009703 D-loop; other site 634500009704 H-loop/switch region; other site 634500009705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500009706 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 634500009707 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 634500009708 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 634500009709 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 634500009710 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 634500009711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500009712 DNA-binding site [nucleotide binding]; DNA binding site 634500009713 UTRA domain; Region: UTRA; pfam07702 634500009714 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 634500009715 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 634500009716 conserved cys residue [active] 634500009717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500009718 Isochorismatase family; Region: Isochorismatase; pfam00857 634500009719 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 634500009720 catalytic triad [active] 634500009721 conserved cis-peptide bond; other site 634500009722 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 634500009723 dimerization interface [polypeptide binding]; other site 634500009724 metal binding site [ion binding]; metal-binding site 634500009725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500009726 non-specific DNA binding site [nucleotide binding]; other site 634500009727 salt bridge; other site 634500009728 sequence-specific DNA binding site [nucleotide binding]; other site 634500009729 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500009730 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 634500009731 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 634500009732 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 634500009733 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 634500009734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500009735 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 634500009736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500009737 motif II; other site 634500009738 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 634500009739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 634500009740 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500009741 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 634500009742 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 634500009743 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 634500009744 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634500009745 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 634500009746 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 634500009747 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500009748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500009751 putative effector binding pocket; other site 634500009752 dimerization interface [polypeptide binding]; other site 634500009753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500009755 putative substrate translocation pore; other site 634500009756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009758 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500009759 putative effector binding pocket; other site 634500009760 dimerization interface [polypeptide binding]; other site 634500009761 Protein of unknown function, DUF606; Region: DUF606; pfam04657 634500009762 Protein of unknown function, DUF606; Region: DUF606; pfam04657 634500009763 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 634500009764 dimer interface [polypeptide binding]; other site 634500009765 FMN binding site [chemical binding]; other site 634500009766 HTH-like domain; Region: HTH_21; pfam13276 634500009767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 634500009768 Integrase core domain; Region: rve; pfam00665 634500009769 Integrase core domain; Region: rve_3; pfam13683 634500009770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 634500009771 Transposase; Region: HTH_Tnp_1; pfam01527 634500009772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009774 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634500009775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500009776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009777 Coenzyme A binding pocket [chemical binding]; other site 634500009778 SnoaL-like domain; Region: SnoaL_4; pfam13577 634500009779 conserved hypothetical protein; Region: TIGR02118 634500009780 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500009781 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500009782 FMN binding site [chemical binding]; other site 634500009783 active site 634500009784 substrate binding site [chemical binding]; other site 634500009785 catalytic residue [active] 634500009786 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 634500009787 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 634500009788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009790 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 634500009791 putative effector binding pocket; other site 634500009792 putative dimerization interface [polypeptide binding]; other site 634500009793 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500009794 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500009795 FMN binding site [chemical binding]; other site 634500009796 active site 634500009797 substrate binding site [chemical binding]; other site 634500009798 catalytic residue [active] 634500009799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500009800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500009801 putative substrate translocation pore; other site 634500009802 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 634500009803 Helix-turn-helix domain; Region: HTH_38; pfam13936 634500009804 Integrase core domain; Region: rve; pfam00665 634500009805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 634500009806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 634500009807 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634500009808 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 634500009809 putative active site [active] 634500009810 metal binding site [ion binding]; metal-binding site 634500009811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009812 dimer interface [polypeptide binding]; other site 634500009813 conserved gate region; other site 634500009814 ABC-ATPase subunit interface; other site 634500009815 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500009816 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634500009817 Walker A/P-loop; other site 634500009818 ATP binding site [chemical binding]; other site 634500009819 Q-loop/lid; other site 634500009820 ABC transporter signature motif; other site 634500009821 Walker B; other site 634500009822 D-loop; other site 634500009823 H-loop/switch region; other site 634500009824 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634500009825 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634500009826 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 634500009827 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 634500009828 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 634500009829 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 634500009830 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 634500009831 molybdopterin cofactor binding site [chemical binding]; other site 634500009832 substrate binding site [chemical binding]; other site 634500009833 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 634500009834 molybdopterin cofactor binding site; other site 634500009835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009836 ABC-ATPase subunit interface; other site 634500009837 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 634500009838 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 634500009839 Walker A/P-loop; other site 634500009840 ATP binding site [chemical binding]; other site 634500009841 Q-loop/lid; other site 634500009842 ABC transporter signature motif; other site 634500009843 Walker B; other site 634500009844 D-loop; other site 634500009845 H-loop/switch region; other site 634500009846 NIL domain; Region: NIL; pfam09383 634500009847 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 634500009848 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 634500009849 transaminase; Reviewed; Region: PRK08068 634500009850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500009851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500009852 homodimer interface [polypeptide binding]; other site 634500009853 catalytic residue [active] 634500009854 short chain dehydrogenase; Provisional; Region: PRK06180 634500009855 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 634500009856 NADP binding site [chemical binding]; other site 634500009857 active site 634500009858 steroid binding site; other site 634500009859 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 634500009860 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 634500009861 putative ligand binding site [chemical binding]; other site 634500009862 NAD binding site [chemical binding]; other site 634500009863 dimerization interface [polypeptide binding]; other site 634500009864 catalytic site [active] 634500009865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009866 Coenzyme A binding pocket [chemical binding]; other site 634500009867 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 634500009868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500009870 dimerization interface [polypeptide binding]; other site 634500009871 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 634500009872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009873 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 634500009874 putative dimerization interface [polypeptide binding]; other site 634500009875 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500009876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500009877 TM-ABC transporter signature motif; other site 634500009878 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500009879 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500009880 Walker A/P-loop; other site 634500009881 ATP binding site [chemical binding]; other site 634500009882 Q-loop/lid; other site 634500009883 ABC transporter signature motif; other site 634500009884 Walker B; other site 634500009885 D-loop; other site 634500009886 H-loop/switch region; other site 634500009887 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500009888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500009889 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 634500009890 putative ligand binding site [chemical binding]; other site 634500009891 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 634500009892 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 634500009893 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 634500009894 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 634500009895 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 634500009896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009897 Coenzyme A binding pocket [chemical binding]; other site 634500009898 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 634500009899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500009900 putative DNA binding site [nucleotide binding]; other site 634500009901 putative Zn2+ binding site [ion binding]; other site 634500009902 AsnC family; Region: AsnC_trans_reg; pfam01037 634500009903 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 634500009904 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500009905 inhibitor-cofactor binding pocket; inhibition site 634500009906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500009907 catalytic residue [active] 634500009908 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 634500009909 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 634500009910 putative ligand binding site [chemical binding]; other site 634500009911 NAD binding site [chemical binding]; other site 634500009912 dimerization interface [polypeptide binding]; other site 634500009913 catalytic site [active] 634500009914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009915 Coenzyme A binding pocket [chemical binding]; other site 634500009916 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500009917 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 634500009918 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500009919 Walker A/P-loop; other site 634500009920 ATP binding site [chemical binding]; other site 634500009921 Q-loop/lid; other site 634500009922 ABC transporter signature motif; other site 634500009923 Walker B; other site 634500009924 D-loop; other site 634500009925 H-loop/switch region; other site 634500009926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500009927 Walker A/P-loop; other site 634500009928 ATP binding site [chemical binding]; other site 634500009929 Q-loop/lid; other site 634500009930 ABC transporter signature motif; other site 634500009931 Walker B; other site 634500009932 D-loop; other site 634500009933 H-loop/switch region; other site 634500009934 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634500009935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009936 dimer interface [polypeptide binding]; other site 634500009937 conserved gate region; other site 634500009938 ABC-ATPase subunit interface; other site 634500009939 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500009940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500009941 dimer interface [polypeptide binding]; other site 634500009942 conserved gate region; other site 634500009943 putative PBP binding loops; other site 634500009944 ABC-ATPase subunit interface; other site 634500009945 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500009946 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 634500009947 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500009948 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 634500009949 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 634500009950 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 634500009951 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 634500009952 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 634500009953 NAD(P) binding site [chemical binding]; other site 634500009954 catalytic residues [active] 634500009955 succinic semialdehyde dehydrogenase; Region: PLN02278 634500009956 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 634500009957 tetramerization interface [polypeptide binding]; other site 634500009958 NAD(P) binding site [chemical binding]; other site 634500009959 catalytic residues [active] 634500009960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500009961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009962 Coenzyme A binding pocket [chemical binding]; other site 634500009963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500009964 Coenzyme A binding pocket [chemical binding]; other site 634500009965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009967 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500009968 putative effector binding pocket; other site 634500009969 dimerization interface [polypeptide binding]; other site 634500009970 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 634500009971 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 634500009972 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 634500009973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 634500009974 putative transcriptional regulator; Provisional; Region: PRK11640 634500009975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009976 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 634500009977 classical (c) SDRs; Region: SDR_c; cd05233 634500009978 NAD(P) binding site [chemical binding]; other site 634500009979 active site 634500009980 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500009981 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 634500009982 FMN binding site [chemical binding]; other site 634500009983 active site 634500009984 substrate binding site [chemical binding]; other site 634500009985 catalytic residue [active] 634500009986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500009989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500009990 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 634500009991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500009992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500009993 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500009994 putative effector binding pocket; other site 634500009995 dimerization interface [polypeptide binding]; other site 634500009996 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500009997 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 634500009998 active site 634500009999 FMN binding site [chemical binding]; other site 634500010000 substrate binding site [chemical binding]; other site 634500010001 putative catalytic residue [active] 634500010002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500010003 Coenzyme A binding pocket [chemical binding]; other site 634500010004 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634500010005 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 634500010006 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 634500010007 putative NAD(P) binding site [chemical binding]; other site 634500010008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500010009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010010 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500010011 putative effector binding pocket; other site 634500010012 dimerization interface [polypeptide binding]; other site 634500010013 short chain dehydrogenase; Provisional; Region: PRK06500 634500010014 classical (c) SDRs; Region: SDR_c; cd05233 634500010015 NAD(P) binding site [chemical binding]; other site 634500010016 active site 634500010017 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 634500010018 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 634500010019 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 634500010020 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 634500010021 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500010022 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 634500010023 peptide binding site [polypeptide binding]; other site 634500010024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500010025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010026 dimer interface [polypeptide binding]; other site 634500010027 conserved gate region; other site 634500010028 putative PBP binding loops; other site 634500010029 ABC-ATPase subunit interface; other site 634500010030 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634500010031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010032 dimer interface [polypeptide binding]; other site 634500010033 conserved gate region; other site 634500010034 putative PBP binding loops; other site 634500010035 ABC-ATPase subunit interface; other site 634500010036 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500010037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500010038 Walker A/P-loop; other site 634500010039 ATP binding site [chemical binding]; other site 634500010040 Q-loop/lid; other site 634500010041 ABC transporter signature motif; other site 634500010042 Walker B; other site 634500010043 D-loop; other site 634500010044 H-loop/switch region; other site 634500010045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500010046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500010047 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500010048 Walker A/P-loop; other site 634500010049 ATP binding site [chemical binding]; other site 634500010050 Q-loop/lid; other site 634500010051 ABC transporter signature motif; other site 634500010052 Walker B; other site 634500010053 D-loop; other site 634500010054 H-loop/switch region; other site 634500010055 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500010056 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500010057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500010058 DNA-binding site [nucleotide binding]; DNA binding site 634500010059 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500010060 AMP nucleosidase; Provisional; Region: PRK08292 634500010061 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 634500010062 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 634500010063 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 634500010064 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634500010065 Walker A/P-loop; other site 634500010066 ATP binding site [chemical binding]; other site 634500010067 Q-loop/lid; other site 634500010068 ABC transporter signature motif; other site 634500010069 Walker B; other site 634500010070 D-loop; other site 634500010071 H-loop/switch region; other site 634500010072 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 634500010073 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634500010074 Walker A/P-loop; other site 634500010075 ATP binding site [chemical binding]; other site 634500010076 Q-loop/lid; other site 634500010077 ABC transporter signature motif; other site 634500010078 Walker B; other site 634500010079 D-loop; other site 634500010080 H-loop/switch region; other site 634500010081 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 634500010082 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634500010083 TM-ABC transporter signature motif; other site 634500010084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500010085 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634500010086 TM-ABC transporter signature motif; other site 634500010087 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 634500010088 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 634500010089 dimerization interface [polypeptide binding]; other site 634500010090 ligand binding site [chemical binding]; other site 634500010091 elongation factor G; Reviewed; Region: PRK00007 634500010092 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 634500010093 G1 box; other site 634500010094 putative GEF interaction site [polypeptide binding]; other site 634500010095 GTP/Mg2+ binding site [chemical binding]; other site 634500010096 Switch I region; other site 634500010097 G2 box; other site 634500010098 G3 box; other site 634500010099 Switch II region; other site 634500010100 G4 box; other site 634500010101 G5 box; other site 634500010102 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 634500010103 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 634500010104 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 634500010105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500010106 dimerization interface [polypeptide binding]; other site 634500010107 putative DNA binding site [nucleotide binding]; other site 634500010108 putative Zn2+ binding site [ion binding]; other site 634500010109 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500010110 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500010111 PemK-like protein; Region: PemK; cl00995 634500010112 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 634500010113 Protein of unknown function (DUF998); Region: DUF998; pfam06197 634500010114 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 634500010115 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 634500010116 FAD binding pocket [chemical binding]; other site 634500010117 FAD binding motif [chemical binding]; other site 634500010118 phosphate binding motif [ion binding]; other site 634500010119 NAD binding pocket [chemical binding]; other site 634500010120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010121 H+ Antiporter protein; Region: 2A0121; TIGR00900 634500010122 putative substrate translocation pore; other site 634500010123 MATE family multidrug exporter; Provisional; Region: PRK10189 634500010124 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 634500010125 lac repressor; Reviewed; Region: lacI; PRK09526 634500010126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500010127 DNA binding site [nucleotide binding] 634500010128 domain linker motif; other site 634500010129 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 634500010130 ligand binding site [chemical binding]; other site 634500010131 dimerization interface (open form) [polypeptide binding]; other site 634500010132 dimerization interface (closed form) [polypeptide binding]; other site 634500010133 hypothetical protein; Provisional; Region: PRK05423 634500010134 Predicted membrane protein [Function unknown]; Region: COG1289 634500010135 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500010136 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634500010137 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500010138 TrkA-N domain; Region: TrkA_N; pfam02254 634500010139 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500010140 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500010141 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500010142 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 634500010143 DNA gyrase inhibitor; Provisional; Region: PRK10016 634500010144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010145 transcriptional activator TtdR; Provisional; Region: PRK09801 634500010146 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500010147 putative effector binding pocket; other site 634500010148 dimerization interface [polypeptide binding]; other site 634500010149 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 634500010150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500010151 NAD(P) binding site [chemical binding]; other site 634500010152 active site 634500010153 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 634500010154 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 634500010155 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 634500010156 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 634500010157 exonuclease I; Provisional; Region: sbcB; PRK11779 634500010158 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 634500010159 active site 634500010160 catalytic site [active] 634500010161 substrate binding site [chemical binding]; other site 634500010162 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 634500010163 Predicted membrane protein [Function unknown]; Region: COG2246 634500010164 GtrA-like protein; Region: GtrA; pfam04138 634500010165 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 634500010166 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 634500010167 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634500010168 Ligand binding site; other site 634500010169 Putative Catalytic site; other site 634500010170 DXD motif; other site 634500010171 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 634500010172 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 634500010173 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 634500010174 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 634500010175 Ligand binding site; other site 634500010176 Putative Catalytic site; other site 634500010177 DXD motif; other site 634500010178 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 634500010179 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 634500010180 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 634500010181 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 634500010182 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 634500010183 catalytic triad [active] 634500010184 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 634500010185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500010186 non-specific DNA binding site [nucleotide binding]; other site 634500010187 salt bridge; other site 634500010188 sequence-specific DNA binding site [nucleotide binding]; other site 634500010189 Cupin domain; Region: Cupin_2; pfam07883 634500010190 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 634500010191 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500010192 Predicted membrane protein [Function unknown]; Region: COG2246 634500010193 GtrA-like protein; Region: GtrA; pfam04138 634500010194 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 634500010195 Ligand binding site; other site 634500010196 Putative Catalytic site; other site 634500010197 DXD motif; other site 634500010198 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 634500010199 Sulfatase; Region: Sulfatase; cl17466 634500010200 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634500010201 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 634500010202 putative NAD(P) binding site [chemical binding]; other site 634500010203 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 634500010204 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 634500010205 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 634500010206 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 634500010207 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 634500010208 NAD binding site [chemical binding]; other site 634500010209 dimerization interface [polypeptide binding]; other site 634500010210 product binding site; other site 634500010211 substrate binding site [chemical binding]; other site 634500010212 zinc binding site [ion binding]; other site 634500010213 catalytic residues [active] 634500010214 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 634500010215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500010216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500010217 homodimer interface [polypeptide binding]; other site 634500010218 catalytic residue [active] 634500010219 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 634500010220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500010221 active site 634500010222 motif I; other site 634500010223 motif II; other site 634500010224 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 634500010225 putative active site pocket [active] 634500010226 4-fold oligomerization interface [polypeptide binding]; other site 634500010227 metal binding residues [ion binding]; metal-binding site 634500010228 3-fold/trimer interface [polypeptide binding]; other site 634500010229 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 634500010230 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 634500010231 putative active site [active] 634500010232 oxyanion strand; other site 634500010233 catalytic triad [active] 634500010234 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 634500010235 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 634500010236 catalytic residues [active] 634500010237 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 634500010238 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 634500010239 substrate binding site [chemical binding]; other site 634500010240 glutamase interaction surface [polypeptide binding]; other site 634500010241 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 634500010242 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 634500010243 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 634500010244 metal binding site [ion binding]; metal-binding site 634500010245 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 634500010246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500010247 substrate binding pocket [chemical binding]; other site 634500010248 membrane-bound complex binding site; other site 634500010249 hinge residues; other site 634500010250 Predicted deacylase [General function prediction only]; Region: COG3608 634500010251 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 634500010252 active site 634500010253 Zn binding site [ion binding]; other site 634500010254 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634500010255 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 634500010256 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 634500010257 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 634500010258 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 634500010259 Probable Catalytic site; other site 634500010260 metal-binding site 634500010261 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 634500010262 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 634500010263 Ligand binding site; other site 634500010264 Methyltransferase domain; Region: Methyltransf_24; pfam13578 634500010265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 634500010266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500010267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500010268 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 634500010269 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 634500010270 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 634500010271 Walker A/P-loop; other site 634500010272 ATP binding site [chemical binding]; other site 634500010273 Q-loop/lid; other site 634500010274 ABC transporter signature motif; other site 634500010275 Walker B; other site 634500010276 D-loop; other site 634500010277 H-loop/switch region; other site 634500010278 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 634500010279 putative carbohydrate binding site [chemical binding]; other site 634500010280 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 634500010281 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 634500010282 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 634500010283 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 634500010284 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 634500010285 substrate binding site; other site 634500010286 tetramer interface; other site 634500010287 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 634500010288 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 634500010289 NADP binding site [chemical binding]; other site 634500010290 active site 634500010291 putative substrate binding site [chemical binding]; other site 634500010292 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 634500010293 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 634500010294 NAD binding site [chemical binding]; other site 634500010295 substrate binding site [chemical binding]; other site 634500010296 homodimer interface [polypeptide binding]; other site 634500010297 active site 634500010298 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 634500010299 UDP-glucose 4-epimerase; Region: PLN02240 634500010300 NAD binding site [chemical binding]; other site 634500010301 homodimer interface [polypeptide binding]; other site 634500010302 active site 634500010303 substrate binding site [chemical binding]; other site 634500010304 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 634500010305 active site 634500010306 tetramer interface; other site 634500010307 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 634500010308 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 634500010309 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 634500010310 putative ADP-binding pocket [chemical binding]; other site 634500010311 colanic acid biosynthesis protein; Provisional; Region: PRK10017 634500010312 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 634500010313 Head binding; Region: Head_binding; pfam09008 634500010314 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 634500010315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 634500010316 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 634500010317 putative ADP-binding pocket [chemical binding]; other site 634500010318 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500010319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500010320 active site 634500010321 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 634500010322 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 634500010323 active site 634500010324 catalytic triad [active] 634500010325 oxyanion hole [active] 634500010326 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 634500010327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 634500010328 active site 634500010329 tyrosine kinase; Provisional; Region: PRK11519 634500010330 Chain length determinant protein; Region: Wzz; pfam02706 634500010331 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 634500010332 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 634500010333 P loop; other site 634500010334 Nucleotide binding site [chemical binding]; other site 634500010335 DTAP/Switch II; other site 634500010336 Switch I; other site 634500010337 Low molecular weight phosphatase family; Region: LMWPc; cd00115 634500010338 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 634500010339 active site 634500010340 polysaccharide export protein Wza; Provisional; Region: PRK15078 634500010341 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 634500010342 SLBB domain; Region: SLBB; pfam10531 634500010343 SLBB domain; Region: SLBB; pfam10531 634500010344 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 634500010345 Bacterial sugar transferase; Region: Bac_transf; pfam02397 634500010346 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 634500010347 FOG: CBS domain [General function prediction only]; Region: COG0517 634500010348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634500010349 Transporter associated domain; Region: CorC_HlyC; smart01091 634500010350 putative assembly protein; Provisional; Region: PRK10833 634500010351 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 634500010352 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 634500010353 trimer interface [polypeptide binding]; other site 634500010354 active site 634500010355 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 634500010356 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 634500010357 ATP-binding site [chemical binding]; other site 634500010358 Sugar specificity; other site 634500010359 Pyrimidine base specificity; other site 634500010360 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 634500010361 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 634500010362 active site 634500010363 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 634500010364 PAS domain S-box; Region: sensory_box; TIGR00229 634500010365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500010366 putative active site [active] 634500010367 heme pocket [chemical binding]; other site 634500010368 PAS fold; Region: PAS_3; pfam08447 634500010369 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 634500010370 PAS fold; Region: PAS_4; pfam08448 634500010371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500010372 putative active site [active] 634500010373 heme pocket [chemical binding]; other site 634500010374 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500010375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500010376 metal binding site [ion binding]; metal-binding site 634500010377 active site 634500010378 I-site; other site 634500010379 putative chaperone; Provisional; Region: PRK11678 634500010380 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 634500010381 nucleotide binding site [chemical binding]; other site 634500010382 putative NEF/HSP70 interaction site [polypeptide binding]; other site 634500010383 SBD interface [polypeptide binding]; other site 634500010384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500010385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500010386 active site 634500010387 catalytic tetrad [active] 634500010388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 634500010389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500010390 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500010391 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 634500010392 Protein export membrane protein; Region: SecD_SecF; cl14618 634500010393 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 634500010394 Protein export membrane protein; Region: SecD_SecF; cl14618 634500010395 putative transporter; Provisional; Region: PRK10504 634500010396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010397 putative substrate translocation pore; other site 634500010398 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 634500010399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500010400 dimerization interface [polypeptide binding]; other site 634500010401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500010402 dimer interface [polypeptide binding]; other site 634500010403 phosphorylation site [posttranslational modification] 634500010404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500010405 ATP binding site [chemical binding]; other site 634500010406 Mg2+ binding site [ion binding]; other site 634500010407 G-X-G motif; other site 634500010408 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 634500010409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500010410 active site 634500010411 phosphorylation site [posttranslational modification] 634500010412 intermolecular recognition site; other site 634500010413 dimerization interface [polypeptide binding]; other site 634500010414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500010415 DNA binding site [nucleotide binding] 634500010416 putative protease; Provisional; Region: PRK15452 634500010417 Peptidase family U32; Region: Peptidase_U32; pfam01136 634500010418 lipid kinase; Reviewed; Region: PRK13054 634500010419 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 634500010420 putative oxidoreductase; Provisional; Region: PRK10083 634500010421 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 634500010422 putative NAD(P) binding site [chemical binding]; other site 634500010423 catalytic Zn binding site [ion binding]; other site 634500010424 structural Zn binding site [ion binding]; other site 634500010425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010426 D-galactonate transporter; Region: 2A0114; TIGR00893 634500010427 putative substrate translocation pore; other site 634500010428 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 634500010429 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 634500010430 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 634500010431 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 634500010432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500010433 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 634500010434 DNA-binding site [nucleotide binding]; DNA binding site 634500010435 FCD domain; Region: FCD; pfam07729 634500010436 Fusaric acid resistance protein family; Region: FUSC; pfam04632 634500010437 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500010438 Class I aldolases; Region: Aldolase_Class_I; cl17187 634500010439 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 634500010440 dimer interface [polypeptide binding]; other site 634500010441 substrate binding site [chemical binding]; other site 634500010442 ATP binding site [chemical binding]; other site 634500010443 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 634500010444 substrate binding site [chemical binding]; other site 634500010445 multimerization interface [polypeptide binding]; other site 634500010446 ATP binding site [chemical binding]; other site 634500010447 potassium uptake protein; Region: kup; TIGR00794 634500010448 K+ potassium transporter; Region: K_trans; pfam02705 634500010449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 634500010450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500010451 Coenzyme A binding pocket [chemical binding]; other site 634500010452 antiporter inner membrane protein; Provisional; Region: PRK11670 634500010453 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 634500010454 Walker A motif; other site 634500010455 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 634500010456 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 634500010457 active site 634500010458 KMSKS motif; other site 634500010459 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 634500010460 tRNA binding surface [nucleotide binding]; other site 634500010461 anticodon binding site; other site 634500010462 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 634500010463 dimer interface [polypeptide binding]; other site 634500010464 putative tRNA-binding site [nucleotide binding]; other site 634500010465 hypothetical protein; Provisional; Region: PRK01821 634500010466 hypothetical protein; Provisional; Region: PRK10711 634500010467 cytidine deaminase; Provisional; Region: PRK09027 634500010468 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 634500010469 active site 634500010470 catalytic motif [active] 634500010471 Zn binding site [ion binding]; other site 634500010472 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 634500010473 active site 634500010474 catalytic motif [active] 634500010475 Zn binding site [ion binding]; other site 634500010476 malate dehydrogenase; Provisional; Region: PRK13529 634500010477 Malic enzyme, N-terminal domain; Region: malic; pfam00390 634500010478 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 634500010479 NAD(P) binding site [chemical binding]; other site 634500010480 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 634500010481 putative active site [active] 634500010482 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 634500010483 YcfA-like protein; Region: YcfA; pfam07927 634500010484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500010485 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500010486 TM-ABC transporter signature motif; other site 634500010487 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500010488 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 634500010489 Walker A/P-loop; other site 634500010490 ATP binding site [chemical binding]; other site 634500010491 Q-loop/lid; other site 634500010492 ABC transporter signature motif; other site 634500010493 Walker B; other site 634500010494 D-loop; other site 634500010495 H-loop/switch region; other site 634500010496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500010497 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 634500010498 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 634500010499 ligand binding site [chemical binding]; other site 634500010500 calcium binding site [ion binding]; other site 634500010501 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 634500010502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500010503 DNA binding site [nucleotide binding] 634500010504 domain linker motif; other site 634500010505 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 634500010506 dimerization interface (closed form) [polypeptide binding]; other site 634500010507 ligand binding site [chemical binding]; other site 634500010508 Predicted membrane protein [Function unknown]; Region: COG2311 634500010509 hypothetical protein; Provisional; Region: PRK10835 634500010510 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 634500010511 homodecamer interface [polypeptide binding]; other site 634500010512 GTP cyclohydrolase I; Provisional; Region: PLN03044 634500010513 active site 634500010514 putative catalytic site residues [active] 634500010515 zinc binding site [ion binding]; other site 634500010516 GTP-CH-I/GFRP interaction surface; other site 634500010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500010519 putative substrate translocation pore; other site 634500010520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500010521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010522 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 634500010523 putative dimerization interface [polypeptide binding]; other site 634500010524 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 634500010525 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 634500010526 substrate binding site [chemical binding]; other site 634500010527 catalytic Zn binding site [ion binding]; other site 634500010528 NAD binding site [chemical binding]; other site 634500010529 structural Zn binding site [ion binding]; other site 634500010530 dimer interface [polypeptide binding]; other site 634500010531 S-formylglutathione hydrolase; Region: PLN02442 634500010532 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 634500010533 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 634500010534 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500010535 N-terminal plug; other site 634500010536 ligand-binding site [chemical binding]; other site 634500010537 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 634500010538 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634500010539 Walker A/P-loop; other site 634500010540 ATP binding site [chemical binding]; other site 634500010541 Q-loop/lid; other site 634500010542 ABC transporter signature motif; other site 634500010543 Walker B; other site 634500010544 D-loop; other site 634500010545 H-loop/switch region; other site 634500010546 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500010547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500010548 dimer interface [polypeptide binding]; other site 634500010549 putative PBP binding regions; other site 634500010550 ABC-ATPase subunit interface; other site 634500010551 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 634500010552 putative ligand binding residues [chemical binding]; other site 634500010553 lysine transporter; Provisional; Region: PRK10836 634500010554 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 634500010555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010556 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 634500010557 putative dimerization interface [polypeptide binding]; other site 634500010558 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 634500010559 endonuclease IV; Provisional; Region: PRK01060 634500010560 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 634500010561 AP (apurinic/apyrimidinic) site pocket; other site 634500010562 DNA interaction; other site 634500010563 Metal-binding active site; metal-binding site 634500010564 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 634500010565 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 634500010566 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 634500010567 active site 634500010568 P-loop; other site 634500010569 phosphorylation site [posttranslational modification] 634500010570 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 634500010571 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 634500010572 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 634500010573 putative substrate binding site [chemical binding]; other site 634500010574 putative ATP binding site [chemical binding]; other site 634500010575 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 634500010576 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500010577 active site 634500010578 phosphorylation site [posttranslational modification] 634500010579 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 634500010580 dimerization domain swap beta strand [polypeptide binding]; other site 634500010581 regulatory protein interface [polypeptide binding]; other site 634500010582 active site 634500010583 regulatory phosphorylation site [posttranslational modification]; other site 634500010584 sugar efflux transporter B; Provisional; Region: PRK15011 634500010585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010586 putative substrate translocation pore; other site 634500010587 Flagellin N-methylase; Region: FliB; cl00497 634500010588 elongation factor P; Provisional; Region: PRK04542 634500010589 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 634500010590 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 634500010591 RNA binding site [nucleotide binding]; other site 634500010592 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 634500010593 RNA binding site [nucleotide binding]; other site 634500010594 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 634500010595 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 634500010596 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 634500010597 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 634500010598 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 634500010599 active site 634500010600 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 634500010601 NlpC/P60 family; Region: NLPC_P60; pfam00877 634500010602 phage resistance protein; Provisional; Region: PRK10551 634500010603 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 634500010604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500010605 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 634500010606 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 634500010607 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 634500010608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010609 dimer interface [polypeptide binding]; other site 634500010610 conserved gate region; other site 634500010611 putative PBP binding loops; other site 634500010612 ABC-ATPase subunit interface; other site 634500010613 microcin C ABC transporter permease; Provisional; Region: PRK15021 634500010614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010615 dimer interface [polypeptide binding]; other site 634500010616 conserved gate region; other site 634500010617 ABC-ATPase subunit interface; other site 634500010618 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 634500010619 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500010620 Walker A/P-loop; other site 634500010621 ATP binding site [chemical binding]; other site 634500010622 Q-loop/lid; other site 634500010623 ABC transporter signature motif; other site 634500010624 Walker B; other site 634500010625 D-loop; other site 634500010626 H-loop/switch region; other site 634500010627 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500010628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500010629 Walker A/P-loop; other site 634500010630 ATP binding site [chemical binding]; other site 634500010631 Q-loop/lid; other site 634500010632 ABC transporter signature motif; other site 634500010633 Walker B; other site 634500010634 D-loop; other site 634500010635 H-loop/switch region; other site 634500010636 hypothetical protein; Provisional; Region: PRK11835 634500010637 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 634500010638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010639 putative substrate translocation pore; other site 634500010640 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 634500010641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500010642 RNA binding surface [nucleotide binding]; other site 634500010643 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 634500010644 active site 634500010645 uracil binding [chemical binding]; other site 634500010646 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 634500010647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500010648 ATP binding site [chemical binding]; other site 634500010649 putative Mg++ binding site [ion binding]; other site 634500010650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500010651 nucleotide binding region [chemical binding]; other site 634500010652 ATP-binding site [chemical binding]; other site 634500010653 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 634500010654 5S rRNA interface [nucleotide binding]; other site 634500010655 CTC domain interface [polypeptide binding]; other site 634500010656 L16 interface [polypeptide binding]; other site 634500010657 Nucleoid-associated protein [General function prediction only]; Region: COG3081 634500010658 nucleoid-associated protein NdpA; Validated; Region: PRK00378 634500010659 hypothetical protein; Provisional; Region: PRK13689 634500010660 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 634500010661 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 634500010662 Sulfatase; Region: Sulfatase; cl17466 634500010663 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 634500010664 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 634500010665 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 634500010666 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 634500010667 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 634500010668 Walker A/P-loop; other site 634500010669 ATP binding site [chemical binding]; other site 634500010670 Q-loop/lid; other site 634500010671 ABC transporter signature motif; other site 634500010672 Walker B; other site 634500010673 D-loop; other site 634500010674 H-loop/switch region; other site 634500010675 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 634500010676 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 634500010677 ApbE family; Region: ApbE; pfam02424 634500010678 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500010679 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 634500010680 trimer interface [polypeptide binding]; other site 634500010681 eyelet of channel; other site 634500010682 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 634500010683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500010684 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500010685 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 634500010686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500010687 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 634500010688 Walker A/P-loop; other site 634500010689 ATP binding site [chemical binding]; other site 634500010690 Q-loop/lid; other site 634500010691 ABC transporter signature motif; other site 634500010692 Walker B; other site 634500010693 D-loop; other site 634500010694 H-loop/switch region; other site 634500010695 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 634500010696 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010697 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010698 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010699 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010700 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010701 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010702 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010703 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010704 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010705 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010706 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010707 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010708 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010709 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010710 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010711 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010712 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010713 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010714 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010715 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010716 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010717 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010718 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010719 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010720 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010721 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010722 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010723 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010724 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010725 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010726 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010727 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010728 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 634500010729 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 634500010730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500010731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500010732 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 634500010733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500010734 ATP binding site [chemical binding]; other site 634500010735 Mg2+ binding site [ion binding]; other site 634500010736 G-X-G motif; other site 634500010737 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634500010738 putative binding surface; other site 634500010739 active site 634500010740 transcriptional regulator RcsB; Provisional; Region: PRK10840 634500010741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500010742 active site 634500010743 phosphorylation site [posttranslational modification] 634500010744 intermolecular recognition site; other site 634500010745 dimerization interface [polypeptide binding]; other site 634500010746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500010747 DNA binding residues [nucleotide binding] 634500010748 dimerization interface [polypeptide binding]; other site 634500010749 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 634500010750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500010751 dimer interface [polypeptide binding]; other site 634500010752 phosphorylation site [posttranslational modification] 634500010753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500010754 ATP binding site [chemical binding]; other site 634500010755 Mg2+ binding site [ion binding]; other site 634500010756 G-X-G motif; other site 634500010757 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 634500010758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500010759 active site 634500010760 phosphorylation site [posttranslational modification] 634500010761 intermolecular recognition site; other site 634500010762 dimerization interface [polypeptide binding]; other site 634500010763 DNA gyrase subunit A; Validated; Region: PRK05560 634500010764 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 634500010765 CAP-like domain; other site 634500010766 active site 634500010767 primary dimer interface [polypeptide binding]; other site 634500010768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010770 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010771 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010772 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010773 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 634500010774 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 634500010775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500010776 S-adenosylmethionine binding site [chemical binding]; other site 634500010777 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 634500010778 ATP cone domain; Region: ATP-cone; pfam03477 634500010779 Class I ribonucleotide reductase; Region: RNR_I; cd01679 634500010780 active site 634500010781 dimer interface [polypeptide binding]; other site 634500010782 catalytic residues [active] 634500010783 effector binding site; other site 634500010784 R2 peptide binding site; other site 634500010785 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 634500010786 dimer interface [polypeptide binding]; other site 634500010787 putative radical transfer pathway; other site 634500010788 diiron center [ion binding]; other site 634500010789 tyrosyl radical; other site 634500010790 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634500010791 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 634500010792 catalytic loop [active] 634500010793 iron binding site [ion binding]; other site 634500010794 hypothetical protein; Provisional; Region: PRK03673 634500010795 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 634500010796 putative MPT binding site; other site 634500010797 Competence-damaged protein; Region: CinA; cl00666 634500010798 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 634500010799 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 634500010800 tetramer interface [polypeptide binding]; other site 634500010801 heme binding pocket [chemical binding]; other site 634500010802 NADPH binding site [chemical binding]; other site 634500010803 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 634500010804 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 634500010805 acyl-activating enzyme (AAE) consensus motif; other site 634500010806 putative AMP binding site [chemical binding]; other site 634500010807 putative active site [active] 634500010808 putative CoA binding site [chemical binding]; other site 634500010809 O-succinylbenzoate synthase; Provisional; Region: PRK05105 634500010810 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 634500010811 active site 634500010812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634500010813 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 634500010814 substrate binding site [chemical binding]; other site 634500010815 oxyanion hole (OAH) forming residues; other site 634500010816 trimer interface [polypeptide binding]; other site 634500010817 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 634500010818 Putative serine esterase (DUF676); Region: DUF676; pfam05057 634500010819 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 634500010820 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 634500010821 dimer interface [polypeptide binding]; other site 634500010822 tetramer interface [polypeptide binding]; other site 634500010823 PYR/PP interface [polypeptide binding]; other site 634500010824 TPP binding site [chemical binding]; other site 634500010825 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 634500010826 TPP-binding site; other site 634500010827 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 634500010828 chorismate binding enzyme; Region: Chorismate_bind; cl10555 634500010829 hypothetical protein; Provisional; Region: PRK10404 634500010830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 634500010831 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500010832 putative metal binding site [ion binding]; other site 634500010833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500010834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010835 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 634500010836 putative dimerization interface [polypeptide binding]; other site 634500010837 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 634500010838 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 634500010839 inner membrane protein; Provisional; Region: PRK10995 634500010840 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 634500010841 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 634500010842 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500010843 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500010844 hypothetical protein; Provisional; Region: PRK09929 634500010845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500010846 Coenzyme A binding pocket [chemical binding]; other site 634500010847 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 634500010848 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634500010849 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 634500010850 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634500010851 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 634500010852 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 634500010853 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 634500010854 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 634500010855 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 634500010856 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 634500010857 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 634500010858 4Fe-4S binding domain; Region: Fer4; pfam00037 634500010859 4Fe-4S binding domain; Region: Fer4; pfam00037 634500010860 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 634500010861 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 634500010862 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 634500010863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 634500010864 catalytic loop [active] 634500010865 iron binding site [ion binding]; other site 634500010866 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 634500010867 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 634500010868 [4Fe-4S] binding site [ion binding]; other site 634500010869 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 634500010870 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 634500010871 SLBB domain; Region: SLBB; pfam10531 634500010872 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 634500010873 NADH dehydrogenase subunit E; Validated; Region: PRK07539 634500010874 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 634500010875 putative dimer interface [polypeptide binding]; other site 634500010876 [2Fe-2S] cluster binding site [ion binding]; other site 634500010877 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 634500010878 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 634500010879 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 634500010880 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 634500010881 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 634500010882 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 634500010883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500010884 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 634500010885 putative dimerization interface [polypeptide binding]; other site 634500010886 aminotransferase AlaT; Validated; Region: PRK09265 634500010887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500010888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500010889 homodimer interface [polypeptide binding]; other site 634500010890 catalytic residue [active] 634500010891 5'-nucleotidase; Provisional; Region: PRK03826 634500010892 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 634500010893 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 634500010894 transmembrane helices; other site 634500010895 putative phosphatase; Provisional; Region: PRK11587 634500010896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 634500010897 active site 634500010898 motif I; other site 634500010899 motif II; other site 634500010900 hypothetical protein; Validated; Region: PRK05445 634500010901 hypothetical protein; Provisional; Region: PRK01816 634500010902 propionate/acetate kinase; Provisional; Region: PRK12379 634500010903 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 634500010904 phosphate acetyltransferase; Reviewed; Region: PRK05632 634500010905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 634500010906 DRTGG domain; Region: DRTGG; pfam07085 634500010907 phosphate acetyltransferase; Region: pta; TIGR00651 634500010908 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 634500010909 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500010910 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 634500010911 Walker A/P-loop; other site 634500010912 ATP binding site [chemical binding]; other site 634500010913 Q-loop/lid; other site 634500010914 ABC transporter signature motif; other site 634500010915 Walker B; other site 634500010916 D-loop; other site 634500010917 H-loop/switch region; other site 634500010918 TOBE domain; Region: TOBE_2; pfam08402 634500010919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500010920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500010921 DNA-binding site [nucleotide binding]; DNA binding site 634500010922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500010923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500010924 homodimer interface [polypeptide binding]; other site 634500010925 catalytic residue [active] 634500010926 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 634500010927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500010928 inhibitor-cofactor binding pocket; inhibition site 634500010929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500010930 catalytic residue [active] 634500010931 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634500010932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500010933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010934 dimer interface [polypeptide binding]; other site 634500010935 conserved gate region; other site 634500010936 putative PBP binding loops; other site 634500010937 ABC-ATPase subunit interface; other site 634500010938 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500010939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010940 dimer interface [polypeptide binding]; other site 634500010941 conserved gate region; other site 634500010942 putative PBP binding loops; other site 634500010943 ABC-ATPase subunit interface; other site 634500010944 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 634500010945 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 634500010946 nudix motif; other site 634500010947 glutathione S-transferase; Provisional; Region: PRK15113 634500010948 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 634500010949 C-terminal domain interface [polypeptide binding]; other site 634500010950 GSH binding site (G-site) [chemical binding]; other site 634500010951 dimer interface [polypeptide binding]; other site 634500010952 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 634500010953 N-terminal domain interface [polypeptide binding]; other site 634500010954 putative dimer interface [polypeptide binding]; other site 634500010955 putative substrate binding pocket (H-site) [chemical binding]; other site 634500010956 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 634500010957 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 634500010958 putative NAD(P) binding site [chemical binding]; other site 634500010959 putative active site [active] 634500010960 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 634500010961 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500010962 Walker A/P-loop; other site 634500010963 ATP binding site [chemical binding]; other site 634500010964 Q-loop/lid; other site 634500010965 ABC transporter signature motif; other site 634500010966 Walker B; other site 634500010967 D-loop; other site 634500010968 H-loop/switch region; other site 634500010969 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500010970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010971 dimer interface [polypeptide binding]; other site 634500010972 conserved gate region; other site 634500010973 putative PBP binding loops; other site 634500010974 ABC-ATPase subunit interface; other site 634500010975 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500010976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500010977 dimer interface [polypeptide binding]; other site 634500010978 conserved gate region; other site 634500010979 putative PBP binding loops; other site 634500010980 ABC-ATPase subunit interface; other site 634500010981 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 634500010982 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500010983 substrate binding pocket [chemical binding]; other site 634500010984 membrane-bound complex binding site; other site 634500010985 hinge residues; other site 634500010986 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 634500010987 Flavoprotein; Region: Flavoprotein; pfam02441 634500010988 amidophosphoribosyltransferase; Provisional; Region: PRK09246 634500010989 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 634500010990 active site 634500010991 tetramer interface [polypeptide binding]; other site 634500010992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500010993 active site 634500010994 colicin V production protein; Provisional; Region: PRK10845 634500010995 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 634500010996 cell division protein DedD; Provisional; Region: PRK11633 634500010997 Sporulation related domain; Region: SPOR; pfam05036 634500010998 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 634500010999 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 634500011000 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 634500011001 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 634500011002 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 634500011003 hypothetical protein; Provisional; Region: PRK10847 634500011004 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634500011005 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 634500011006 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 634500011007 dimerization interface 3.5A [polypeptide binding]; other site 634500011008 active site 634500011009 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 634500011010 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634500011011 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 634500011012 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 634500011013 ligand binding site [chemical binding]; other site 634500011014 NAD binding site [chemical binding]; other site 634500011015 catalytic site [active] 634500011016 homodimer interface [polypeptide binding]; other site 634500011017 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500011018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500011019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500011020 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634500011021 EamA-like transporter family; Region: EamA; pfam00892 634500011022 EamA-like transporter family; Region: EamA; pfam00892 634500011023 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 634500011024 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 634500011025 active site residue [active] 634500011026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500011027 DNA-binding site [nucleotide binding]; DNA binding site 634500011028 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500011029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500011030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500011031 homodimer interface [polypeptide binding]; other site 634500011032 catalytic residue [active] 634500011033 putative transporter; Provisional; Region: PRK12382 634500011034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500011035 putative substrate translocation pore; other site 634500011036 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 634500011037 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500011038 ligand binding site [chemical binding]; other site 634500011039 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500011040 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500011041 Walker A/P-loop; other site 634500011042 ATP binding site [chemical binding]; other site 634500011043 Q-loop/lid; other site 634500011044 ABC transporter signature motif; other site 634500011045 Walker B; other site 634500011046 D-loop; other site 634500011047 H-loop/switch region; other site 634500011048 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500011049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500011050 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500011051 TM-ABC transporter signature motif; other site 634500011052 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500011053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500011054 TM-ABC transporter signature motif; other site 634500011055 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 634500011056 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 634500011057 N- and C-terminal domain interface [polypeptide binding]; other site 634500011058 active site 634500011059 MgATP binding site [chemical binding]; other site 634500011060 catalytic site [active] 634500011061 metal binding site [ion binding]; metal-binding site 634500011062 carbohydrate binding site [chemical binding]; other site 634500011063 putative homodimer interface [polypeptide binding]; other site 634500011064 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 634500011065 putative active site [active] 634500011066 Protein of unknown function (DUF419); Region: DUF419; cl15265 634500011067 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 634500011068 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 634500011069 dimer interface [polypeptide binding]; other site 634500011070 active site 634500011071 Uncharacterized conserved protein [Function unknown]; Region: COG4121 634500011072 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 634500011073 YfcL protein; Region: YfcL; pfam08891 634500011074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 634500011075 hypothetical protein; Provisional; Region: PRK10621 634500011076 Predicted permeases [General function prediction only]; Region: COG0730 634500011077 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 634500011078 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 634500011079 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 634500011080 Tetramer interface [polypeptide binding]; other site 634500011081 active site 634500011082 FMN-binding site [chemical binding]; other site 634500011083 HemK family putative methylases; Region: hemK_fam; TIGR00536 634500011084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500011085 S-adenosylmethionine binding site [chemical binding]; other site 634500011086 hypothetical protein; Provisional; Region: PRK04946 634500011087 Smr domain; Region: Smr; pfam01713 634500011088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 634500011089 catalytic core [active] 634500011090 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 634500011091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 634500011092 substrate binding site [chemical binding]; other site 634500011093 oxyanion hole (OAH) forming residues; other site 634500011094 trimer interface [polypeptide binding]; other site 634500011095 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 634500011096 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634500011097 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 634500011098 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 634500011099 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 634500011100 dimer interface [polypeptide binding]; other site 634500011101 active site 634500011102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 634500011103 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 634500011104 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 634500011105 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 634500011106 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 634500011107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500011108 binding surface 634500011109 TPR motif; other site 634500011110 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 634500011111 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 634500011112 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634500011113 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 634500011114 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 634500011115 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 634500011116 heme exporter protein CcmC; Region: ccmC; TIGR01191 634500011117 heme exporter protein CcmB; Region: ccmB; TIGR01190 634500011118 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 634500011119 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 634500011120 Walker A/P-loop; other site 634500011121 ATP binding site [chemical binding]; other site 634500011122 Q-loop/lid; other site 634500011123 ABC transporter signature motif; other site 634500011124 Walker B; other site 634500011125 D-loop; other site 634500011126 H-loop/switch region; other site 634500011127 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 634500011128 integrase; Provisional; Region: PRK09692 634500011129 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 634500011130 active site 634500011131 Int/Topo IB signature motif; other site 634500011132 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 634500011133 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 634500011134 Baseplate J-like protein; Region: Baseplate_J; pfam04865 634500011135 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 634500011136 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 634500011137 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 634500011138 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 634500011139 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 634500011140 active site 634500011141 death-on-curing family protein; Region: DOC_P1; TIGR01550 634500011142 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 634500011143 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 634500011144 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 634500011145 large terminase protein; Provisional; Region: 17; PHA02533 634500011146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500011147 non-specific DNA binding site [nucleotide binding]; other site 634500011148 salt bridge; other site 634500011149 sequence-specific DNA binding site [nucleotide binding]; other site 634500011150 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 634500011151 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 634500011152 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 634500011153 Phage NinH protein; Region: Phage_NinH; pfam06322 634500011154 NinB protein; Region: NinB; pfam05772 634500011155 Replication protein P; Region: Phage_lambda_P; pfam06992 634500011156 ParB-like nuclease domain; Region: ParBc; cl02129 634500011157 KorB domain; Region: KorB; pfam08535 634500011158 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 634500011159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500011160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500011161 non-specific DNA binding site [nucleotide binding]; other site 634500011162 salt bridge; other site 634500011163 sequence-specific DNA binding site [nucleotide binding]; other site 634500011164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500011165 non-specific DNA binding site [nucleotide binding]; other site 634500011166 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 634500011167 salt bridge; other site 634500011168 sequence-specific DNA binding site [nucleotide binding]; other site 634500011169 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 634500011170 Catalytic site [active] 634500011171 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 634500011172 anti-RssB factor; Provisional; Region: PRK10244 634500011173 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 634500011174 RecT family; Region: RecT; pfam03837 634500011175 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 634500011176 putative transposase OrfB; Reviewed; Region: PHA02517 634500011177 HTH-like domain; Region: HTH_21; pfam13276 634500011178 Integrase core domain; Region: rve; pfam00665 634500011179 Integrase core domain; Region: rve_3; pfam13683 634500011180 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 634500011181 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 634500011182 cofactor binding site; other site 634500011183 DNA binding site [nucleotide binding] 634500011184 substrate interaction site [chemical binding]; other site 634500011185 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 634500011186 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 634500011187 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 634500011188 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 634500011189 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 634500011190 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 634500011191 Cache domain; Region: Cache_1; pfam02743 634500011192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500011193 dimerization interface [polypeptide binding]; other site 634500011194 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 634500011195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500011196 dimer interface [polypeptide binding]; other site 634500011197 putative CheW interface [polypeptide binding]; other site 634500011198 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 634500011199 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500011200 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 634500011201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500011202 putative substrate translocation pore; other site 634500011203 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 634500011204 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634500011205 Ligand Binding Site [chemical binding]; other site 634500011206 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 634500011207 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634500011208 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500011209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500011210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 634500011211 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 634500011212 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500011213 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500011214 aminotransferase; Validated; Region: PRK08175 634500011215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500011216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500011217 homodimer interface [polypeptide binding]; other site 634500011218 catalytic residue [active] 634500011219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500011220 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500011221 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 634500011222 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 634500011223 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 634500011224 Histidine kinase; Region: His_kinase; pfam06580 634500011225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500011226 ATP binding site [chemical binding]; other site 634500011227 Mg2+ binding site [ion binding]; other site 634500011228 G-X-G motif; other site 634500011229 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 634500011230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500011231 active site 634500011232 phosphorylation site [posttranslational modification] 634500011233 intermolecular recognition site; other site 634500011234 dimerization interface [polypeptide binding]; other site 634500011235 LytTr DNA-binding domain; Region: LytTR; pfam04397 634500011236 glucokinase, proteobacterial type; Region: glk; TIGR00749 634500011237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500011238 nucleotide binding site [chemical binding]; other site 634500011239 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 634500011240 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 634500011241 dimer interface [polypeptide binding]; other site 634500011242 PYR/PP interface [polypeptide binding]; other site 634500011243 TPP binding site [chemical binding]; other site 634500011244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500011245 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 634500011246 TPP-binding site [chemical binding]; other site 634500011247 dimer interface [polypeptide binding]; other site 634500011248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500011249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500011250 active site 634500011251 catalytic tetrad [active] 634500011252 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 634500011253 manganese transport protein MntH; Reviewed; Region: PRK00701 634500011254 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 634500011255 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 634500011256 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 634500011257 Nucleoside recognition; Region: Gate; pfam07670 634500011258 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 634500011259 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500011260 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500011261 active site 634500011262 non-prolyl cis peptide bond; other site 634500011263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500011264 substrate binding pocket [chemical binding]; other site 634500011265 membrane-bound complex binding site; other site 634500011266 hinge residues; other site 634500011267 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500011268 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 634500011269 dimer interface [polypeptide binding]; other site 634500011270 active site 634500011271 non-prolyl cis peptide bond; other site 634500011272 insertion regions; other site 634500011273 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500011274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500011275 substrate binding pocket [chemical binding]; other site 634500011276 membrane-bound complex binding site; other site 634500011277 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 634500011278 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 634500011279 active site residue [active] 634500011280 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 634500011281 active site residue [active] 634500011282 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 634500011283 active site residue [active] 634500011284 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 634500011285 active site residue [active] 634500011286 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 634500011287 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 634500011288 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 634500011289 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 634500011290 active site 634500011291 HIGH motif; other site 634500011292 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 634500011293 active site 634500011294 KMSKS motif; other site 634500011295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500011296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500011297 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 634500011298 putative dimerization interface [polypeptide binding]; other site 634500011299 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 634500011300 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 634500011301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 634500011302 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 634500011303 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 634500011304 nucleotide binding pocket [chemical binding]; other site 634500011305 K-X-D-G motif; other site 634500011306 catalytic site [active] 634500011307 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 634500011308 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 634500011309 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 634500011310 Dimer interface [polypeptide binding]; other site 634500011311 BRCT sequence motif; other site 634500011312 cell division protein ZipA; Provisional; Region: PRK03427 634500011313 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 634500011314 FtsZ protein binding site [polypeptide binding]; other site 634500011315 putative sulfate transport protein CysZ; Validated; Region: PRK04949 634500011316 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 634500011317 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634500011318 dimer interface [polypeptide binding]; other site 634500011319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500011320 catalytic residue [active] 634500011321 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 634500011322 dimerization domain swap beta strand [polypeptide binding]; other site 634500011323 regulatory protein interface [polypeptide binding]; other site 634500011324 active site 634500011325 regulatory phosphorylation site [posttranslational modification]; other site 634500011326 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 634500011327 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 634500011328 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 634500011329 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 634500011330 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 634500011331 HPr interaction site; other site 634500011332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 634500011333 active site 634500011334 phosphorylation site [posttranslational modification] 634500011335 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 634500011336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500011337 active site 634500011338 cytosine deaminase; Provisional; Region: PRK05985 634500011339 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 634500011340 active site 634500011341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634500011342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500011343 Walker A/P-loop; other site 634500011344 ATP binding site [chemical binding]; other site 634500011345 Q-loop/lid; other site 634500011346 ABC transporter signature motif; other site 634500011347 Walker B; other site 634500011348 D-loop; other site 634500011349 H-loop/switch region; other site 634500011350 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634500011351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634500011352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500011353 Walker A/P-loop; other site 634500011354 ATP binding site [chemical binding]; other site 634500011355 Q-loop/lid; other site 634500011356 ABC transporter signature motif; other site 634500011357 Walker B; other site 634500011358 D-loop; other site 634500011359 H-loop/switch region; other site 634500011360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500011361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 634500011362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011363 dimer interface [polypeptide binding]; other site 634500011364 conserved gate region; other site 634500011365 putative PBP binding loops; other site 634500011366 ABC-ATPase subunit interface; other site 634500011367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500011368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011369 dimer interface [polypeptide binding]; other site 634500011370 putative PBP binding loops; other site 634500011371 ABC-ATPase subunit interface; other site 634500011372 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500011373 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 634500011374 SnoaL-like domain; Region: SnoaL_2; pfam12680 634500011375 cytosine deaminase; Provisional; Region: PRK05985 634500011376 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 634500011377 active site 634500011378 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500011379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500011380 DNA-binding site [nucleotide binding]; DNA binding site 634500011381 FCD domain; Region: FCD; pfam07729 634500011382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500011383 dimerization interface [polypeptide binding]; other site 634500011384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500011385 dimer interface [polypeptide binding]; other site 634500011386 phosphorylation site [posttranslational modification] 634500011387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500011388 ATP binding site [chemical binding]; other site 634500011389 Mg2+ binding site [ion binding]; other site 634500011390 G-X-G motif; other site 634500011391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 634500011392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500011393 active site 634500011394 phosphorylation site [posttranslational modification] 634500011395 intermolecular recognition site; other site 634500011396 dimerization interface [polypeptide binding]; other site 634500011397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500011398 DNA binding site [nucleotide binding] 634500011399 cysteine synthase B; Region: cysM; TIGR01138 634500011400 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 634500011401 dimer interface [polypeptide binding]; other site 634500011402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500011403 catalytic residue [active] 634500011404 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 634500011405 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 634500011406 Walker A/P-loop; other site 634500011407 ATP binding site [chemical binding]; other site 634500011408 Q-loop/lid; other site 634500011409 ABC transporter signature motif; other site 634500011410 Walker B; other site 634500011411 D-loop; other site 634500011412 H-loop/switch region; other site 634500011413 TOBE-like domain; Region: TOBE_3; pfam12857 634500011414 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500011415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011416 dimer interface [polypeptide binding]; other site 634500011417 conserved gate region; other site 634500011418 putative PBP binding loops; other site 634500011419 ABC-ATPase subunit interface; other site 634500011420 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500011421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011422 dimer interface [polypeptide binding]; other site 634500011423 conserved gate region; other site 634500011424 putative PBP binding loops; other site 634500011425 ABC-ATPase subunit interface; other site 634500011426 thiosulfate transporter subunit; Provisional; Region: PRK10852 634500011427 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 634500011428 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 634500011429 putative dimerization interface [polypeptide binding]; other site 634500011430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500011431 putative ligand binding site [chemical binding]; other site 634500011432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500011433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500011434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500011435 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500011436 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500011437 TM-ABC transporter signature motif; other site 634500011438 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 634500011439 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500011440 Walker A/P-loop; other site 634500011441 ATP binding site [chemical binding]; other site 634500011442 Q-loop/lid; other site 634500011443 ABC transporter signature motif; other site 634500011444 Walker B; other site 634500011445 D-loop; other site 634500011446 H-loop/switch region; other site 634500011447 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500011448 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 634500011449 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 634500011450 putative ligand binding site [chemical binding]; other site 634500011451 xylose isomerase; Provisional; Region: PRK05474 634500011452 xylose isomerase; Region: xylose_isom_A; TIGR02630 634500011453 xylulokinase; Provisional; Region: PRK15027 634500011454 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 634500011455 N- and C-terminal domain interface [polypeptide binding]; other site 634500011456 active site 634500011457 MgATP binding site [chemical binding]; other site 634500011458 catalytic site [active] 634500011459 metal binding site [ion binding]; metal-binding site 634500011460 xylulose binding site [chemical binding]; other site 634500011461 homodimer interface [polypeptide binding]; other site 634500011462 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 634500011463 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 634500011464 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 634500011465 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 634500011466 putative acetyltransferase; Provisional; Region: PRK03624 634500011467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500011468 Coenzyme A binding pocket [chemical binding]; other site 634500011469 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 634500011470 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634500011471 active site 634500011472 metal binding site [ion binding]; metal-binding site 634500011473 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 634500011474 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 634500011475 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 634500011476 Malic enzyme, N-terminal domain; Region: malic; pfam00390 634500011477 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 634500011478 putative NAD(P) binding site [chemical binding]; other site 634500011479 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 634500011480 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 634500011481 Homeodomain-like domain; Region: HTH_23; pfam13384 634500011482 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 634500011483 prephenate dehydrogenase; Provisional; Region: PRK08655 634500011484 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 634500011485 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 634500011486 substrate binding site [chemical binding]; other site 634500011487 dimer interface [polypeptide binding]; other site 634500011488 catalytic triad [active] 634500011489 dihydroxyacetone kinase; Provisional; Region: PRK14479 634500011490 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 634500011491 DAK2 domain; Region: Dak2; pfam02734 634500011492 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 634500011493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500011494 putative substrate translocation pore; other site 634500011495 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 634500011496 transaldolase-like protein; Provisional; Region: PTZ00411 634500011497 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 634500011498 active site 634500011499 dimer interface [polypeptide binding]; other site 634500011500 catalytic residue [active] 634500011501 transketolase; Reviewed; Region: PRK12753 634500011502 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 634500011503 TPP-binding site [chemical binding]; other site 634500011504 dimer interface [polypeptide binding]; other site 634500011505 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634500011506 PYR/PP interface [polypeptide binding]; other site 634500011507 dimer interface [polypeptide binding]; other site 634500011508 TPP binding site [chemical binding]; other site 634500011509 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634500011510 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 634500011511 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 634500011512 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 634500011513 dimer interface [polypeptide binding]; other site 634500011514 ADP-ribose binding site [chemical binding]; other site 634500011515 active site 634500011516 nudix motif; other site 634500011517 metal binding site [ion binding]; metal-binding site 634500011518 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 634500011519 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 634500011520 metal binding site [ion binding]; metal-binding site 634500011521 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500011522 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500011523 TM-ABC transporter signature motif; other site 634500011524 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500011525 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500011526 TM-ABC transporter signature motif; other site 634500011527 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500011528 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500011529 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 634500011530 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500011531 Walker A/P-loop; other site 634500011532 ATP binding site [chemical binding]; other site 634500011533 Q-loop/lid; other site 634500011534 ABC transporter signature motif; other site 634500011535 Walker B; other site 634500011536 D-loop; other site 634500011537 H-loop/switch region; other site 634500011538 L-asparagine permease; Provisional; Region: PRK15049 634500011539 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500011540 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 634500011541 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 634500011542 HAMP domain; Region: HAMP; pfam00672 634500011543 Histidine kinase; Region: HisKA_3; pfam07730 634500011544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500011545 ATP binding site [chemical binding]; other site 634500011546 Mg2+ binding site [ion binding]; other site 634500011547 G-X-G motif; other site 634500011548 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 634500011549 Protein export membrane protein; Region: SecD_SecF; cl14618 634500011550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500011551 Coenzyme A binding pocket [chemical binding]; other site 634500011552 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 634500011553 ArsC family; Region: ArsC; pfam03960 634500011554 putative catalytic residues [active] 634500011555 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 634500011556 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 634500011557 metal binding site [ion binding]; metal-binding site 634500011558 dimer interface [polypeptide binding]; other site 634500011559 hypothetical protein; Provisional; Region: PRK13664 634500011560 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 634500011561 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 634500011562 Helicase; Region: Helicase_RecD; pfam05127 634500011563 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 634500011564 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 634500011565 Predicted metalloprotease [General function prediction only]; Region: COG2321 634500011566 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 634500011567 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 634500011568 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 634500011569 ATP binding site [chemical binding]; other site 634500011570 active site 634500011571 substrate binding site [chemical binding]; other site 634500011572 lipoprotein; Provisional; Region: PRK11679 634500011573 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 634500011574 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 634500011575 dihydrodipicolinate synthase; Region: dapA; TIGR00674 634500011576 dimer interface [polypeptide binding]; other site 634500011577 active site 634500011578 catalytic residue [active] 634500011579 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 634500011580 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 634500011581 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 634500011582 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 634500011583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 634500011584 catalytic triad [active] 634500011585 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634500011586 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 634500011587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500011588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500011589 metal binding site [ion binding]; metal-binding site 634500011590 active site 634500011591 I-site; other site 634500011592 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 634500011593 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500011594 active site 634500011595 metal binding site [ion binding]; metal-binding site 634500011596 hexamer interface [polypeptide binding]; other site 634500011597 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500011598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500011599 Walker A/P-loop; other site 634500011600 ATP binding site [chemical binding]; other site 634500011601 Q-loop/lid; other site 634500011602 ABC transporter signature motif; other site 634500011603 Walker B; other site 634500011604 D-loop; other site 634500011605 H-loop/switch region; other site 634500011606 TOBE domain; Region: TOBE_2; pfam08402 634500011607 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 634500011608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011609 dimer interface [polypeptide binding]; other site 634500011610 conserved gate region; other site 634500011611 putative PBP binding loops; other site 634500011612 ABC-ATPase subunit interface; other site 634500011613 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500011614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011615 dimer interface [polypeptide binding]; other site 634500011616 conserved gate region; other site 634500011617 putative PBP binding loops; other site 634500011618 ABC-ATPase subunit interface; other site 634500011619 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634500011620 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500011621 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500011622 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500011623 DNA binding site [nucleotide binding] 634500011624 domain linker motif; other site 634500011625 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500011626 DsrE/DsrF-like family; Region: DrsE; pfam02635 634500011627 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 634500011628 Peptidase family M48; Region: Peptidase_M48; pfam01435 634500011629 DNA replication initiation factor; Provisional; Region: PRK08084 634500011630 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 634500011631 uracil transporter; Provisional; Region: PRK10720 634500011632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500011633 active site 634500011634 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 634500011635 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 634500011636 dimerization interface [polypeptide binding]; other site 634500011637 putative ATP binding site [chemical binding]; other site 634500011638 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 634500011639 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 634500011640 active site 634500011641 substrate binding site [chemical binding]; other site 634500011642 cosubstrate binding site; other site 634500011643 catalytic site [active] 634500011644 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 634500011645 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 634500011646 Walker A/P-loop; other site 634500011647 ATP binding site [chemical binding]; other site 634500011648 Q-loop/lid; other site 634500011649 ABC transporter signature motif; other site 634500011650 Walker B; other site 634500011651 D-loop; other site 634500011652 H-loop/switch region; other site 634500011653 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 634500011654 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 634500011655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011656 ABC-ATPase subunit interface; other site 634500011657 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 634500011658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011659 conserved gate region; other site 634500011660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500011661 putative PBP binding loops; other site 634500011662 ABC-ATPase subunit interface; other site 634500011663 polyphosphate kinase; Provisional; Region: PRK05443 634500011664 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 634500011665 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 634500011666 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 634500011667 putative active site [active] 634500011668 catalytic site [active] 634500011669 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 634500011670 domain interface [polypeptide binding]; other site 634500011671 active site 634500011672 catalytic site [active] 634500011673 exopolyphosphatase; Provisional; Region: PRK10854 634500011674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500011675 nucleotide binding site [chemical binding]; other site 634500011676 tellurite resistance protein TehB; Provisional; Region: PRK11207 634500011677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500011678 S-adenosylmethionine binding site [chemical binding]; other site 634500011679 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 634500011680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500011681 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 634500011682 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 634500011683 MgtE intracellular N domain; Region: MgtE_N; smart00924 634500011684 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 634500011685 Divalent cation transporter; Region: MgtE; cl00786 634500011686 GMP synthase; Reviewed; Region: guaA; PRK00074 634500011687 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 634500011688 AMP/PPi binding site [chemical binding]; other site 634500011689 candidate oxyanion hole; other site 634500011690 catalytic triad [active] 634500011691 potential glutamine specificity residues [chemical binding]; other site 634500011692 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 634500011693 ATP Binding subdomain [chemical binding]; other site 634500011694 Ligand Binding sites [chemical binding]; other site 634500011695 Dimerization subdomain; other site 634500011696 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 634500011697 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634500011698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 634500011699 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 634500011700 active site 634500011701 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 634500011702 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 634500011703 generic binding surface II; other site 634500011704 generic binding surface I; other site 634500011705 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 634500011706 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 634500011707 active site 634500011708 Zn binding site [ion binding]; other site 634500011709 MerC mercury resistance protein; Region: MerC; cl03934 634500011710 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 634500011711 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 634500011712 Trp docking motif [polypeptide binding]; other site 634500011713 putative active site [active] 634500011714 GTP-binding protein Der; Reviewed; Region: PRK00093 634500011715 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 634500011716 G1 box; other site 634500011717 GTP/Mg2+ binding site [chemical binding]; other site 634500011718 Switch I region; other site 634500011719 G2 box; other site 634500011720 Switch II region; other site 634500011721 G3 box; other site 634500011722 G4 box; other site 634500011723 G5 box; other site 634500011724 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 634500011725 G1 box; other site 634500011726 GTP/Mg2+ binding site [chemical binding]; other site 634500011727 Switch I region; other site 634500011728 G2 box; other site 634500011729 G3 box; other site 634500011730 Switch II region; other site 634500011731 G4 box; other site 634500011732 G5 box; other site 634500011733 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 634500011734 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 634500011735 Trp docking motif [polypeptide binding]; other site 634500011736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 634500011737 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 634500011738 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 634500011739 dimer interface [polypeptide binding]; other site 634500011740 motif 1; other site 634500011741 active site 634500011742 motif 2; other site 634500011743 motif 3; other site 634500011744 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 634500011745 anticodon binding site; other site 634500011746 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 634500011747 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 634500011748 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 634500011749 cytoskeletal protein RodZ; Provisional; Region: PRK10856 634500011750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500011751 non-specific DNA binding site [nucleotide binding]; other site 634500011752 salt bridge; other site 634500011753 sequence-specific DNA binding site [nucleotide binding]; other site 634500011754 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 634500011755 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 634500011756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500011757 binding surface 634500011758 TPR motif; other site 634500011759 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 634500011760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500011761 FeS/SAM binding site; other site 634500011762 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 634500011763 active site 634500011764 multimer interface [polypeptide binding]; other site 634500011765 penicillin-binding protein 1C; Provisional; Region: PRK11240 634500011766 Transglycosylase; Region: Transgly; pfam00912 634500011767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 634500011768 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 634500011769 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 634500011770 MG2 domain; Region: A2M_N; pfam01835 634500011771 Alpha-2-macroglobulin family; Region: A2M; pfam00207 634500011772 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 634500011773 surface patch; other site 634500011774 thioester region; other site 634500011775 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 634500011776 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 634500011777 active site residue [active] 634500011778 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 634500011779 active site residue [active] 634500011780 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 634500011781 aminopeptidase B; Provisional; Region: PRK05015 634500011782 Peptidase; Region: DUF3663; pfam12404 634500011783 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 634500011784 interface (dimer of trimers) [polypeptide binding]; other site 634500011785 Substrate-binding/catalytic site; other site 634500011786 Zn-binding sites [ion binding]; other site 634500011787 cysteine desulfurase; Provisional; Region: PRK14012 634500011788 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 634500011789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500011790 catalytic residue [active] 634500011791 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 634500011792 Rrf2 family protein; Region: rrf2_super; TIGR00738 634500011793 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 634500011794 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634500011795 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 634500011796 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 634500011797 active site 634500011798 dimerization interface [polypeptide binding]; other site 634500011799 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 634500011800 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 634500011801 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 634500011802 PRD domain; Region: PRD; pfam00874 634500011803 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 634500011804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500011805 putative substrate translocation pore; other site 634500011806 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 634500011807 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 634500011808 dimer interface [polypeptide binding]; other site 634500011809 active site 634500011810 glycine-pyridoxal phosphate binding site [chemical binding]; other site 634500011811 folate binding site [chemical binding]; other site 634500011812 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 634500011813 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 634500011814 heme-binding site [chemical binding]; other site 634500011815 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 634500011816 FAD binding pocket [chemical binding]; other site 634500011817 FAD binding motif [chemical binding]; other site 634500011818 phosphate binding motif [ion binding]; other site 634500011819 beta-alpha-beta structure motif; other site 634500011820 NAD binding pocket [chemical binding]; other site 634500011821 Heme binding pocket [chemical binding]; other site 634500011822 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 634500011823 Nitrogen regulatory protein P-II; Region: P-II; smart00938 634500011824 response regulator GlrR; Provisional; Region: PRK15115 634500011825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500011826 active site 634500011827 phosphorylation site [posttranslational modification] 634500011828 intermolecular recognition site; other site 634500011829 dimerization interface [polypeptide binding]; other site 634500011830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500011831 Walker A motif; other site 634500011832 ATP binding site [chemical binding]; other site 634500011833 Walker B motif; other site 634500011834 arginine finger; other site 634500011835 hypothetical protein; Provisional; Region: PRK10722 634500011836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 634500011837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500011838 dimer interface [polypeptide binding]; other site 634500011839 phosphorylation site [posttranslational modification] 634500011840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500011841 ATP binding site [chemical binding]; other site 634500011842 Mg2+ binding site [ion binding]; other site 634500011843 G-X-G motif; other site 634500011844 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 634500011845 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 634500011846 dimerization interface [polypeptide binding]; other site 634500011847 ATP binding site [chemical binding]; other site 634500011848 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 634500011849 dimerization interface [polypeptide binding]; other site 634500011850 ATP binding site [chemical binding]; other site 634500011851 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 634500011852 putative active site [active] 634500011853 catalytic triad [active] 634500011854 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 634500011855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500011856 substrate binding pocket [chemical binding]; other site 634500011857 membrane-bound complex binding site; other site 634500011858 hinge residues; other site 634500011859 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500011860 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500011861 catalytic residue [active] 634500011862 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 634500011863 nucleoside/Zn binding site; other site 634500011864 dimer interface [polypeptide binding]; other site 634500011865 catalytic motif [active] 634500011866 hypothetical protein; Provisional; Region: PRK11590 634500011867 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 634500011868 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 634500011869 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500011870 active site turn [active] 634500011871 phosphorylation site [posttranslational modification] 634500011872 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500011873 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 634500011874 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 634500011875 putative active site [active] 634500011876 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500011877 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 634500011878 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500011879 putative active site [active] 634500011880 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 634500011881 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 634500011882 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 634500011883 active site 634500011884 hydrophilic channel; other site 634500011885 dimerization interface [polypeptide binding]; other site 634500011886 catalytic residues [active] 634500011887 active site lid [active] 634500011888 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 634500011889 Recombination protein O N terminal; Region: RecO_N; pfam11967 634500011890 Recombination protein O C terminal; Region: RecO_C; pfam02565 634500011891 GTPase Era; Reviewed; Region: era; PRK00089 634500011892 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 634500011893 G1 box; other site 634500011894 GTP/Mg2+ binding site [chemical binding]; other site 634500011895 Switch I region; other site 634500011896 G2 box; other site 634500011897 Switch II region; other site 634500011898 G3 box; other site 634500011899 G4 box; other site 634500011900 G5 box; other site 634500011901 KH domain; Region: KH_2; pfam07650 634500011902 ribonuclease III; Reviewed; Region: rnc; PRK00102 634500011903 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 634500011904 dimerization interface [polypeptide binding]; other site 634500011905 active site 634500011906 metal binding site [ion binding]; metal-binding site 634500011907 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 634500011908 dsRNA binding site [nucleotide binding]; other site 634500011909 signal peptidase I; Provisional; Region: PRK10861 634500011910 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 634500011911 Catalytic site [active] 634500011912 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 634500011913 GTP-binding protein LepA; Provisional; Region: PRK05433 634500011914 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 634500011915 G1 box; other site 634500011916 putative GEF interaction site [polypeptide binding]; other site 634500011917 GTP/Mg2+ binding site [chemical binding]; other site 634500011918 Switch I region; other site 634500011919 G2 box; other site 634500011920 G3 box; other site 634500011921 Switch II region; other site 634500011922 G4 box; other site 634500011923 G5 box; other site 634500011924 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 634500011925 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 634500011926 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 634500011927 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 634500011928 putative ligand binding residues [chemical binding]; other site 634500011929 SoxR reducing system protein RseC; Provisional; Region: PRK10862 634500011930 anti-sigma E factor; Provisional; Region: rseB; PRK09455 634500011931 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 634500011932 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 634500011933 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 634500011934 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 634500011935 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 634500011936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500011937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500011938 DNA binding residues [nucleotide binding] 634500011939 L-aspartate oxidase; Provisional; Region: PRK09077 634500011940 L-aspartate oxidase; Provisional; Region: PRK06175 634500011941 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 634500011942 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 634500011943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500011944 S-adenosylmethionine binding site [chemical binding]; other site 634500011945 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 634500011946 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634500011947 ATP binding site [chemical binding]; other site 634500011948 Mg++ binding site [ion binding]; other site 634500011949 motif III; other site 634500011950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500011951 nucleotide binding region [chemical binding]; other site 634500011952 ATP-binding site [chemical binding]; other site 634500011953 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 634500011954 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 634500011955 ligand binding site [chemical binding]; other site 634500011956 active site 634500011957 UGI interface [polypeptide binding]; other site 634500011958 catalytic site [active] 634500011959 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 634500011960 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 634500011961 dimer interface [polypeptide binding]; other site 634500011962 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 634500011963 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 634500011964 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 634500011965 recombination and repair protein; Provisional; Region: PRK10869 634500011966 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 634500011967 Walker A/P-loop; other site 634500011968 ATP binding site [chemical binding]; other site 634500011969 Q-loop/lid; other site 634500011970 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 634500011971 ABC transporter signature motif; other site 634500011972 Walker B; other site 634500011973 D-loop; other site 634500011974 H-loop/switch region; other site 634500011975 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 634500011976 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 634500011977 hypothetical protein; Validated; Region: PRK01777 634500011978 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 634500011979 putative coenzyme Q binding site [chemical binding]; other site 634500011980 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 634500011981 SmpB-tmRNA interface; other site 634500011982 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 634500011983 ATP binding site [chemical binding]; other site 634500011984 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 634500011985 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 634500011986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500011987 Coenzyme A binding pocket [chemical binding]; other site 634500011988 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 634500011989 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 634500011990 S-methylmethionine transporter; Provisional; Region: PRK11387 634500011991 hypothetical protein; Provisional; Region: PRK10556 634500011992 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 634500011993 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 634500011994 catalytic residues [active] 634500011995 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 634500011996 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 634500011997 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 634500011998 Class I ribonucleotide reductase; Region: RNR_I; cd01679 634500011999 active site 634500012000 dimer interface [polypeptide binding]; other site 634500012001 catalytic residues [active] 634500012002 effector binding site; other site 634500012003 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 634500012004 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 634500012005 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 634500012006 dimer interface [polypeptide binding]; other site 634500012007 putative radical transfer pathway; other site 634500012008 diiron center [ion binding]; other site 634500012009 tyrosyl radical; other site 634500012010 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 634500012011 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 634500012012 Walker A/P-loop; other site 634500012013 ATP binding site [chemical binding]; other site 634500012014 Q-loop/lid; other site 634500012015 ABC transporter signature motif; other site 634500012016 Walker B; other site 634500012017 D-loop; other site 634500012018 H-loop/switch region; other site 634500012019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 634500012020 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 634500012021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012022 dimer interface [polypeptide binding]; other site 634500012023 conserved gate region; other site 634500012024 putative PBP binding loops; other site 634500012025 ABC-ATPase subunit interface; other site 634500012026 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 634500012027 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 634500012028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012029 putative substrate translocation pore; other site 634500012030 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500012031 transcriptional repressor MprA; Provisional; Region: PRK10870 634500012032 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 634500012033 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 634500012034 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500012035 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500012036 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634500012037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012038 putative substrate translocation pore; other site 634500012039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012040 putative methyltransferase; Provisional; Region: PRK10864 634500012041 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 634500012042 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 634500012043 thioredoxin 2; Provisional; Region: PRK10996 634500012044 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 634500012045 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 634500012046 catalytic residues [active] 634500012047 Uncharacterized conserved protein [Function unknown]; Region: COG3148 634500012048 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 634500012049 CoA binding domain; Region: CoA_binding_2; pfam13380 634500012050 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 634500012051 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 634500012052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500012053 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 634500012054 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 634500012055 domain interface [polypeptide binding]; other site 634500012056 putative active site [active] 634500012057 catalytic site [active] 634500012058 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 634500012059 domain interface [polypeptide binding]; other site 634500012060 putative active site [active] 634500012061 catalytic site [active] 634500012062 lipoprotein; Provisional; Region: PRK10759 634500012063 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 634500012064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012065 putative substrate translocation pore; other site 634500012066 protein disaggregation chaperone; Provisional; Region: PRK10865 634500012067 Clp amino terminal domain; Region: Clp_N; pfam02861 634500012068 Clp amino terminal domain; Region: Clp_N; pfam02861 634500012069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500012070 Walker A motif; other site 634500012071 ATP binding site [chemical binding]; other site 634500012072 Walker B motif; other site 634500012073 arginine finger; other site 634500012074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500012075 Walker A motif; other site 634500012076 ATP binding site [chemical binding]; other site 634500012077 Walker B motif; other site 634500012078 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 634500012079 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 634500012080 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 634500012081 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 634500012082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500012083 RNA binding surface [nucleotide binding]; other site 634500012084 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 634500012085 active site 634500012086 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 634500012087 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 634500012088 30S subunit binding site; other site 634500012089 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 634500012090 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 634500012091 Prephenate dehydratase; Region: PDT; pfam00800 634500012092 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 634500012093 putative L-Phe binding site [chemical binding]; other site 634500012094 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 634500012095 putative ligand binding residues [chemical binding]; other site 634500012096 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500012097 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 634500012098 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500012099 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 634500012100 Chorismate mutase type II; Region: CM_2; cl00693 634500012101 prephenate dehydrogenase; Validated; Region: PRK08507 634500012102 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 634500012103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 634500012104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 634500012105 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 634500012106 Coenzyme A binding pocket [chemical binding]; other site 634500012107 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 634500012108 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 634500012109 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 634500012110 RimM N-terminal domain; Region: RimM; pfam01782 634500012111 PRC-barrel domain; Region: PRC; pfam05239 634500012112 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 634500012113 signal recognition particle protein; Provisional; Region: PRK10867 634500012114 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 634500012115 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 634500012116 P loop; other site 634500012117 GTP binding site [chemical binding]; other site 634500012118 Signal peptide binding domain; Region: SRP_SPB; pfam02978 634500012119 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 634500012120 hypothetical protein; Provisional; Region: PRK11573 634500012121 Domain of unknown function DUF21; Region: DUF21; pfam01595 634500012122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 634500012123 Transporter associated domain; Region: CorC_HlyC; smart01091 634500012124 S-ribosylhomocysteinase; Provisional; Region: PRK02260 634500012125 glutamate--cysteine ligase; Provisional; Region: PRK02107 634500012126 Predicted membrane protein [Function unknown]; Region: COG1238 634500012127 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 634500012128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500012129 motif II; other site 634500012130 carbon storage regulator; Provisional; Region: PRK01712 634500012131 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 634500012132 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 634500012133 motif 1; other site 634500012134 active site 634500012135 motif 2; other site 634500012136 motif 3; other site 634500012137 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 634500012138 DHHA1 domain; Region: DHHA1; pfam02272 634500012139 recombination regulator RecX; Reviewed; Region: recX; PRK00117 634500012140 recombinase A; Provisional; Region: recA; PRK09354 634500012141 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 634500012142 hexamer interface [polypeptide binding]; other site 634500012143 Walker A motif; other site 634500012144 ATP binding site [chemical binding]; other site 634500012145 Walker B motif; other site 634500012146 hypothetical protein; Validated; Region: PRK03661 634500012147 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 634500012148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500012149 S-adenosylmethionine binding site [chemical binding]; other site 634500012150 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 634500012151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 634500012152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500012153 catalytic residue [active] 634500012154 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500012155 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 634500012156 metal binding site [ion binding]; metal-binding site 634500012157 dimer interface [polypeptide binding]; other site 634500012158 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500012159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500012160 substrate binding pocket [chemical binding]; other site 634500012161 membrane-bound complex binding site; other site 634500012162 hinge residues; other site 634500012163 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012165 dimer interface [polypeptide binding]; other site 634500012166 conserved gate region; other site 634500012167 putative PBP binding loops; other site 634500012168 ABC-ATPase subunit interface; other site 634500012169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012170 dimer interface [polypeptide binding]; other site 634500012171 conserved gate region; other site 634500012172 putative PBP binding loops; other site 634500012173 ABC-ATPase subunit interface; other site 634500012174 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 634500012175 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500012176 Walker A/P-loop; other site 634500012177 ATP binding site [chemical binding]; other site 634500012178 Q-loop/lid; other site 634500012179 ABC transporter signature motif; other site 634500012180 Walker B; other site 634500012181 D-loop; other site 634500012182 H-loop/switch region; other site 634500012183 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500012184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500012185 DNA-binding site [nucleotide binding]; DNA binding site 634500012186 FCD domain; Region: FCD; pfam07729 634500012187 Transglycosylase SLT domain; Region: SLT_2; pfam13406 634500012188 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500012189 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500012190 catalytic residue [active] 634500012191 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 634500012192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012193 putative substrate translocation pore; other site 634500012194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012195 Domain of unknown function (DUF718); Region: DUF718; pfam05336 634500012196 short chain dehydrogenase; Provisional; Region: PRK08628 634500012197 classical (c) SDRs; Region: SDR_c; cd05233 634500012198 NAD(P) binding site [chemical binding]; other site 634500012199 active site 634500012200 Amidohydrolase; Region: Amidohydro_2; pfam04909 634500012201 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 634500012202 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 634500012203 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 634500012204 putative active site pocket [active] 634500012205 metal binding site [ion binding]; metal-binding site 634500012206 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 634500012207 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 634500012208 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 634500012209 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 634500012210 NAD binding site [chemical binding]; other site 634500012211 homotetramer interface [polypeptide binding]; other site 634500012212 homodimer interface [polypeptide binding]; other site 634500012213 active site 634500012214 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500012215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500012216 DNA-binding site [nucleotide binding]; DNA binding site 634500012217 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500012218 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 634500012219 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 634500012220 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 634500012221 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 634500012222 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 634500012223 [4Fe-4S] binding site [ion binding]; other site 634500012224 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500012225 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500012226 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500012227 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 634500012228 molybdopterin cofactor binding site; other site 634500012229 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 634500012230 transcriptional regulator NarL; Provisional; Region: PRK10651 634500012231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500012232 active site 634500012233 phosphorylation site [posttranslational modification] 634500012234 intermolecular recognition site; other site 634500012235 dimerization interface [polypeptide binding]; other site 634500012236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500012237 DNA binding residues [nucleotide binding] 634500012238 dimerization interface [polypeptide binding]; other site 634500012239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500012240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500012241 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 634500012242 putative effector binding pocket; other site 634500012243 putative dimerization interface [polypeptide binding]; other site 634500012244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500012245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500012246 active site 634500012247 catalytic tetrad [active] 634500012248 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 634500012249 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 634500012250 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 634500012251 Fimbrial protein; Region: Fimbrial; cl01416 634500012252 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 634500012253 PapC N-terminal domain; Region: PapC_N; pfam13954 634500012254 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500012255 PapC C-terminal domain; Region: PapC_C; pfam13953 634500012256 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 634500012257 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 634500012258 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 634500012259 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 634500012260 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 634500012261 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 634500012262 MutS domain I; Region: MutS_I; pfam01624 634500012263 MutS domain II; Region: MutS_II; pfam05188 634500012264 MutS domain III; Region: MutS_III; pfam05192 634500012265 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 634500012266 Walker A/P-loop; other site 634500012267 ATP binding site [chemical binding]; other site 634500012268 Q-loop/lid; other site 634500012269 ABC transporter signature motif; other site 634500012270 Walker B; other site 634500012271 D-loop; other site 634500012272 H-loop/switch region; other site 634500012273 putative amidase; Provisional; Region: PRK06169 634500012274 Amidase; Region: Amidase; pfam01425 634500012275 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 634500012276 Na binding site [ion binding]; other site 634500012277 Isochorismatase family; Region: Isochorismatase; pfam00857 634500012278 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 634500012279 catalytic triad [active] 634500012280 conserved cis-peptide bond; other site 634500012281 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 634500012282 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 634500012283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500012284 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634500012285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500012286 DNA binding residues [nucleotide binding] 634500012287 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 634500012288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 634500012289 Peptidase family M23; Region: Peptidase_M23; pfam01551 634500012290 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 634500012291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500012292 S-adenosylmethionine binding site [chemical binding]; other site 634500012293 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 634500012294 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 634500012295 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 634500012296 Permutation of conserved domain; other site 634500012297 active site 634500012298 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 634500012299 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 634500012300 homotrimer interaction site [polypeptide binding]; other site 634500012301 zinc binding site [ion binding]; other site 634500012302 CDP-binding sites; other site 634500012303 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 634500012304 substrate binding site; other site 634500012305 dimer interface; other site 634500012306 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 634500012307 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 634500012308 hypothetical protein; Provisional; Region: PRK10726 634500012309 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 634500012310 ligand-binding site [chemical binding]; other site 634500012311 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 634500012312 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 634500012313 CysD dimerization site [polypeptide binding]; other site 634500012314 G1 box; other site 634500012315 putative GEF interaction site [polypeptide binding]; other site 634500012316 GTP/Mg2+ binding site [chemical binding]; other site 634500012317 Switch I region; other site 634500012318 G2 box; other site 634500012319 G3 box; other site 634500012320 Switch II region; other site 634500012321 G4 box; other site 634500012322 G5 box; other site 634500012323 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 634500012324 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 634500012325 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 634500012326 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 634500012327 Active Sites [active] 634500012328 siroheme synthase; Provisional; Region: cysG; PRK10637 634500012329 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 634500012330 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 634500012331 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 634500012332 active site 634500012333 SAM binding site [chemical binding]; other site 634500012334 homodimer interface [polypeptide binding]; other site 634500012335 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 634500012336 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 634500012337 metal binding site [ion binding]; metal-binding site 634500012338 YCII-related domain; Region: YCII; cl00999 634500012339 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 634500012340 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 634500012341 Active Sites [active] 634500012342 sulfite reductase subunit beta; Provisional; Region: PRK13504 634500012343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 634500012344 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 634500012345 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 634500012346 Flavodoxin; Region: Flavodoxin_1; pfam00258 634500012347 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 634500012348 FAD binding pocket [chemical binding]; other site 634500012349 FAD binding motif [chemical binding]; other site 634500012350 catalytic residues [active] 634500012351 NAD binding pocket [chemical binding]; other site 634500012352 phosphate binding motif [ion binding]; other site 634500012353 beta-alpha-beta structure motif; other site 634500012354 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 634500012355 active site 634500012356 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 634500012357 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 634500012358 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 634500012359 putative deaminase; Validated; Region: PRK06846 634500012360 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 634500012361 active site 634500012362 enolase; Provisional; Region: eno; PRK00077 634500012363 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 634500012364 dimer interface [polypeptide binding]; other site 634500012365 metal binding site [ion binding]; metal-binding site 634500012366 substrate binding pocket [chemical binding]; other site 634500012367 CTP synthetase; Validated; Region: pyrG; PRK05380 634500012368 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 634500012369 Catalytic site [active] 634500012370 active site 634500012371 UTP binding site [chemical binding]; other site 634500012372 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 634500012373 active site 634500012374 putative oxyanion hole; other site 634500012375 catalytic triad [active] 634500012376 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 634500012377 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 634500012378 homodimer interface [polypeptide binding]; other site 634500012379 metal binding site [ion binding]; metal-binding site 634500012380 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 634500012381 homodimer interface [polypeptide binding]; other site 634500012382 active site 634500012383 putative chemical substrate binding site [chemical binding]; other site 634500012384 metal binding site [ion binding]; metal-binding site 634500012385 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 634500012386 HD domain; Region: HD_4; pfam13328 634500012387 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 634500012388 synthetase active site [active] 634500012389 NTP binding site [chemical binding]; other site 634500012390 metal binding site [ion binding]; metal-binding site 634500012391 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 634500012392 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 634500012393 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 634500012394 TRAM domain; Region: TRAM; pfam01938 634500012395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 634500012396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500012397 S-adenosylmethionine binding site [chemical binding]; other site 634500012398 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 634500012399 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 634500012400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500012401 dimerization interface [polypeptide binding]; other site 634500012402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500012403 dimer interface [polypeptide binding]; other site 634500012404 phosphorylation site [posttranslational modification] 634500012405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500012406 ATP binding site [chemical binding]; other site 634500012407 Mg2+ binding site [ion binding]; other site 634500012408 G-X-G motif; other site 634500012409 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 634500012410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500012411 active site 634500012412 phosphorylation site [posttranslational modification] 634500012413 intermolecular recognition site; other site 634500012414 dimerization interface [polypeptide binding]; other site 634500012415 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634500012416 putative binding surface; other site 634500012417 active site 634500012418 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 634500012419 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 634500012420 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634500012421 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 634500012422 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 634500012423 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 634500012424 active site 634500012425 tetramer interface [polypeptide binding]; other site 634500012426 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 634500012427 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 634500012428 active site 634500012429 tetramer interface [polypeptide binding]; other site 634500012430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012431 D-galactonate transporter; Region: 2A0114; TIGR00893 634500012432 putative substrate translocation pore; other site 634500012433 galactarate dehydratase; Region: galactar-dH20; TIGR03248 634500012434 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 634500012435 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 634500012436 flavodoxin; Provisional; Region: PRK08105 634500012437 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 634500012438 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 634500012439 probable active site [active] 634500012440 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 634500012441 SecY interacting protein Syd; Provisional; Region: PRK04968 634500012442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 634500012443 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 634500012444 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 634500012445 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 634500012446 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 634500012447 flap endonuclease-like protein; Provisional; Region: PRK09482 634500012448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 634500012449 active site 634500012450 metal binding site 1 [ion binding]; metal-binding site 634500012451 putative 5' ssDNA interaction site; other site 634500012452 metal binding site 3; metal-binding site 634500012453 metal binding site 2 [ion binding]; metal-binding site 634500012454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 634500012455 putative DNA binding site [nucleotide binding]; other site 634500012456 putative metal binding site [ion binding]; other site 634500012457 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 634500012458 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 634500012459 hypothetical protein; Provisional; Region: PRK10873 634500012460 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 634500012461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500012462 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 634500012463 dimerization interface [polypeptide binding]; other site 634500012464 substrate binding pocket [chemical binding]; other site 634500012465 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 634500012466 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 634500012467 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 634500012468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500012469 catalytic residue [active] 634500012470 Fe-S metabolism associated domain; Region: SufE; cl00951 634500012471 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 634500012472 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 634500012473 putative ATP binding site [chemical binding]; other site 634500012474 putative substrate interface [chemical binding]; other site 634500012475 murein transglycosylase A; Provisional; Region: mltA; PRK11162 634500012476 MltA specific insert domain; Region: MltA; smart00925 634500012477 3D domain; Region: 3D; pfam06725 634500012478 AMIN domain; Region: AMIN; pfam11741 634500012479 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 634500012480 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 634500012481 active site 634500012482 metal binding site [ion binding]; metal-binding site 634500012483 N-acetylglutamate synthase; Validated; Region: PRK05279 634500012484 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 634500012485 putative feedback inhibition sensing region; other site 634500012486 putative nucleotide binding site [chemical binding]; other site 634500012487 putative substrate binding site [chemical binding]; other site 634500012488 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 634500012489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500012490 Coenzyme A binding pocket [chemical binding]; other site 634500012491 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 634500012492 AAA domain; Region: AAA_30; pfam13604 634500012493 Family description; Region: UvrD_C_2; pfam13538 634500012494 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 634500012495 protease3; Provisional; Region: PRK15101 634500012496 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 634500012497 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634500012498 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634500012499 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 634500012500 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 634500012501 hypothetical protein; Provisional; Region: PRK10332 634500012502 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 634500012503 hypothetical protein; Provisional; Region: PRK10557 634500012504 hypothetical protein; Provisional; Region: PRK10506 634500012505 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 634500012506 thymidylate synthase; Reviewed; Region: thyA; PRK01827 634500012507 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 634500012508 dimerization interface [polypeptide binding]; other site 634500012509 active site 634500012510 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 634500012511 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 634500012512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 634500012513 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 634500012514 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 634500012515 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 634500012516 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 634500012517 putative active site [active] 634500012518 Ap4A binding site [chemical binding]; other site 634500012519 nudix motif; other site 634500012520 putative metal binding site [ion binding]; other site 634500012521 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 634500012522 putative DNA-binding cleft [nucleotide binding]; other site 634500012523 putative DNA clevage site; other site 634500012524 molecular lever; other site 634500012525 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 634500012526 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 634500012527 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 634500012528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500012529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500012530 active site 634500012531 catalytic tetrad [active] 634500012532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012533 lysophospholipid transporter LplT; Provisional; Region: PRK11195 634500012534 putative substrate translocation pore; other site 634500012535 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 634500012536 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 634500012537 putative acyl-acceptor binding pocket; other site 634500012538 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 634500012539 acyl-activating enzyme (AAE) consensus motif; other site 634500012540 putative AMP binding site [chemical binding]; other site 634500012541 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 634500012542 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 634500012543 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 634500012544 Protein export membrane protein; Region: SecD_SecF; cl14618 634500012545 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500012546 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 634500012547 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 634500012548 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 634500012549 Protein export membrane protein; Region: SecD_SecF; cl14618 634500012550 Protein export membrane protein; Region: SecD_SecF; cl14618 634500012551 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 634500012552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500012553 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500012554 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 634500012555 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634500012556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634500012557 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 634500012558 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 634500012559 molybdopterin cofactor binding site [chemical binding]; other site 634500012560 substrate binding site [chemical binding]; other site 634500012561 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 634500012562 molybdopterin cofactor binding site; other site 634500012563 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 634500012564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500012565 DNA binding site [nucleotide binding] 634500012566 domain linker motif; other site 634500012567 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 634500012568 dimerization interface (closed form) [polypeptide binding]; other site 634500012569 ligand binding site [chemical binding]; other site 634500012570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500012571 Coenzyme A binding pocket [chemical binding]; other site 634500012572 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 634500012573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500012574 DNA-binding site [nucleotide binding]; DNA binding site 634500012575 FCD domain; Region: FCD; pfam07729 634500012576 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 634500012577 active site 634500012578 P-loop; other site 634500012579 phosphorylation site [posttranslational modification] 634500012580 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 634500012581 beta-galactosidase; Region: BGL; TIGR03356 634500012582 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 634500012583 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 634500012584 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 634500012585 active site 634500012586 methionine cluster; other site 634500012587 phosphorylation site [posttranslational modification] 634500012588 metal binding site [ion binding]; metal-binding site 634500012589 diaminopimelate decarboxylase; Provisional; Region: PRK11165 634500012590 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 634500012591 active site 634500012592 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634500012593 substrate binding site [chemical binding]; other site 634500012594 catalytic residues [active] 634500012595 dimer interface [polypeptide binding]; other site 634500012596 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 634500012597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500012598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500012599 dimerization interface [polypeptide binding]; other site 634500012600 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500012601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012602 putative substrate translocation pore; other site 634500012603 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 634500012604 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 634500012605 aspartate racemase; Region: asp_race; TIGR00035 634500012606 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 634500012607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012608 dimer interface [polypeptide binding]; other site 634500012609 conserved gate region; other site 634500012610 putative PBP binding loops; other site 634500012611 ABC-ATPase subunit interface; other site 634500012612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 634500012613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012614 dimer interface [polypeptide binding]; other site 634500012615 ABC-ATPase subunit interface; other site 634500012616 putative PBP binding loops; other site 634500012617 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 634500012618 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 634500012619 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 634500012620 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500012621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500012622 substrate binding pocket [chemical binding]; other site 634500012623 membrane-bound complex binding site; other site 634500012624 hinge residues; other site 634500012625 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634500012626 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500012627 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500012628 putative active site [active] 634500012629 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 634500012630 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 634500012631 dimer interface [polypeptide binding]; other site 634500012632 putative anticodon binding site; other site 634500012633 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 634500012634 motif 1; other site 634500012635 active site 634500012636 motif 2; other site 634500012637 motif 3; other site 634500012638 peptide chain release factor 2; Validated; Region: prfB; PRK00578 634500012639 This domain is found in peptide chain release factors; Region: PCRF; smart00937 634500012640 RF-1 domain; Region: RF-1; pfam00472 634500012641 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 634500012642 DHH family; Region: DHH; pfam01368 634500012643 DHHA1 domain; Region: DHHA1; pfam02272 634500012644 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 634500012645 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 634500012646 dimerization domain [polypeptide binding]; other site 634500012647 dimer interface [polypeptide binding]; other site 634500012648 catalytic residues [active] 634500012649 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 634500012650 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 634500012651 active site 634500012652 Int/Topo IB signature motif; other site 634500012653 flavodoxin FldB; Provisional; Region: PRK12359 634500012654 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 634500012655 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 634500012656 putative global regulator; Reviewed; Region: PRK09559 634500012657 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 634500012658 hemolysin; Provisional; Region: PRK15087 634500012659 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 634500012660 HD domain; Region: HD_3; pfam13023 634500012661 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634500012662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500012663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500012664 putative active site [active] 634500012665 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 634500012666 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 634500012667 active site turn [active] 634500012668 phosphorylation site [posttranslational modification] 634500012669 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 634500012670 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 634500012671 beta-galactosidase; Region: BGL; TIGR03356 634500012672 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 634500012673 classical (c) SDRs; Region: SDR_c; cd05233 634500012674 NAD(P) binding site [chemical binding]; other site 634500012675 active site 634500012676 glycine dehydrogenase; Provisional; Region: PRK05367 634500012677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 634500012678 tetramer interface [polypeptide binding]; other site 634500012679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500012680 catalytic residue [active] 634500012681 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 634500012682 tetramer interface [polypeptide binding]; other site 634500012683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500012684 catalytic residue [active] 634500012685 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 634500012686 lipoyl attachment site [posttranslational modification]; other site 634500012687 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 634500012688 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 634500012689 oxidoreductase; Provisional; Region: PRK08013 634500012690 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 634500012691 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 634500012692 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 634500012693 proline aminopeptidase P II; Provisional; Region: PRK10879 634500012694 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 634500012695 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 634500012696 active site 634500012697 hypothetical protein; Reviewed; Region: PRK01736 634500012698 Z-ring-associated protein; Provisional; Region: PRK10972 634500012699 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 634500012700 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 634500012701 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 634500012702 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 634500012703 ligand binding site [chemical binding]; other site 634500012704 NAD binding site [chemical binding]; other site 634500012705 tetramer interface [polypeptide binding]; other site 634500012706 catalytic site [active] 634500012707 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 634500012708 L-serine binding site [chemical binding]; other site 634500012709 ACT domain interface; other site 634500012710 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 634500012711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634500012712 active site 634500012713 dimer interface [polypeptide binding]; other site 634500012714 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 634500012715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500012716 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 634500012717 putative dimerization interface [polypeptide binding]; other site 634500012718 Uncharacterized conserved protein [Function unknown]; Region: COG2968 634500012719 oxidative stress defense protein; Provisional; Region: PRK11087 634500012720 arginine exporter protein; Provisional; Region: PRK09304 634500012721 mechanosensitive channel MscS; Provisional; Region: PRK10334 634500012722 Mechanosensitive ion channel; Region: MS_channel; pfam00924 634500012723 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 634500012724 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 634500012725 active site 634500012726 intersubunit interface [polypeptide binding]; other site 634500012727 zinc binding site [ion binding]; other site 634500012728 Na+ binding site [ion binding]; other site 634500012729 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 634500012730 Phosphoglycerate kinase; Region: PGK; pfam00162 634500012731 substrate binding site [chemical binding]; other site 634500012732 hinge regions; other site 634500012733 ADP binding site [chemical binding]; other site 634500012734 catalytic site [active] 634500012735 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 634500012736 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 634500012737 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 634500012738 transketolase; Reviewed; Region: PRK12753 634500012739 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 634500012740 TPP-binding site [chemical binding]; other site 634500012741 dimer interface [polypeptide binding]; other site 634500012742 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 634500012743 PYR/PP interface [polypeptide binding]; other site 634500012744 dimer interface [polypeptide binding]; other site 634500012745 TPP binding site [chemical binding]; other site 634500012746 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 634500012747 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 634500012748 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 634500012749 agmatinase; Region: agmatinase; TIGR01230 634500012750 oligomer interface [polypeptide binding]; other site 634500012751 putative active site [active] 634500012752 Mn binding site [ion binding]; other site 634500012753 arginine decarboxylase; Provisional; Region: PRK05354 634500012754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 634500012755 dimer interface [polypeptide binding]; other site 634500012756 active site 634500012757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634500012758 catalytic residues [active] 634500012759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 634500012760 S-adenosylmethionine synthetase; Validated; Region: PRK05250 634500012761 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 634500012762 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 634500012763 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 634500012764 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 634500012765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012766 putative substrate translocation pore; other site 634500012767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500012768 hypothetical protein; Provisional; Region: PRK04860 634500012769 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 634500012770 DNA-specific endonuclease I; Provisional; Region: PRK15137 634500012771 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 634500012772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 634500012773 RNA methyltransferase, RsmE family; Region: TIGR00046 634500012774 glutathione synthetase; Provisional; Region: PRK05246 634500012775 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 634500012776 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 634500012777 hypothetical protein; Validated; Region: PRK00228 634500012778 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 634500012779 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 634500012780 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500012781 Walker A motif; other site 634500012782 ATP binding site [chemical binding]; other site 634500012783 Walker B motif; other site 634500012784 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 634500012785 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634500012786 catalytic residue [active] 634500012787 YGGT family; Region: YGGT; pfam02325 634500012788 YGGT family; Region: YGGT; pfam02325 634500012789 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 634500012790 active site 634500012791 dimerization interface [polypeptide binding]; other site 634500012792 HemN family oxidoreductase; Provisional; Region: PRK05660 634500012793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500012794 FeS/SAM binding site; other site 634500012795 HemN C-terminal domain; Region: HemN_C; pfam06969 634500012796 hypothetical protein; Provisional; Region: PRK10626 634500012797 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 634500012798 hypothetical protein; Provisional; Region: PRK11702 634500012799 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 634500012800 adenine DNA glycosylase; Provisional; Region: PRK10880 634500012801 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 634500012802 minor groove reading motif; other site 634500012803 helix-hairpin-helix signature motif; other site 634500012804 substrate binding pocket [chemical binding]; other site 634500012805 active site 634500012806 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 634500012807 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 634500012808 DNA binding and oxoG recognition site [nucleotide binding] 634500012809 oxidative damage protection protein; Provisional; Region: PRK05408 634500012810 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 634500012811 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 634500012812 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 634500012813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 634500012814 catalytic residue [active] 634500012815 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 634500012816 hypothetical protein; Provisional; Region: PRK02399 634500012817 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 634500012818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500012819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500012820 MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane...; Region: MATH; cl02446 634500012821 putative substrate binding site [chemical binding]; other site 634500012822 ornithine decarboxylase; Provisional; Region: PRK13578 634500012823 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 634500012824 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 634500012825 homodimer interface [polypeptide binding]; other site 634500012826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500012827 catalytic residue [active] 634500012828 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 634500012829 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 634500012830 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500012831 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 634500012832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500012833 NAD(P) binding site [chemical binding]; other site 634500012834 active site 634500012835 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 634500012836 Transcriptional regulator [Transcription]; Region: IclR; COG1414 634500012837 Bacterial transcriptional regulator; Region: IclR; pfam01614 634500012838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500012839 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500012840 substrate binding pocket [chemical binding]; other site 634500012841 membrane-bound complex binding site; other site 634500012842 hinge residues; other site 634500012843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012844 dimer interface [polypeptide binding]; other site 634500012845 conserved gate region; other site 634500012846 putative PBP binding loops; other site 634500012847 ABC-ATPase subunit interface; other site 634500012848 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012850 dimer interface [polypeptide binding]; other site 634500012851 conserved gate region; other site 634500012852 putative PBP binding loops; other site 634500012853 ABC-ATPase subunit interface; other site 634500012854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500012855 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500012856 Walker A/P-loop; other site 634500012857 ATP binding site [chemical binding]; other site 634500012858 Q-loop/lid; other site 634500012859 ABC transporter signature motif; other site 634500012860 Walker B; other site 634500012861 D-loop; other site 634500012862 H-loop/switch region; other site 634500012863 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 634500012864 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500012865 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 634500012866 Helix-turn-helix domain; Region: HTH_38; pfam13936 634500012867 Homeodomain-like domain; Region: HTH_32; pfam13565 634500012868 Integrase core domain; Region: rve; pfam00665 634500012869 HTH-like domain; Region: HTH_21; pfam13276 634500012870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 634500012871 Integrase core domain; Region: rve; pfam00665 634500012872 Integrase core domain; Region: rve_3; pfam13683 634500012873 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 634500012874 DNA-binding interface [nucleotide binding]; DNA binding site 634500012875 AAA ATPase domain; Region: AAA_15; pfam13175 634500012876 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 634500012877 putative active site [active] 634500012878 putative metal-binding site [ion binding]; other site 634500012879 Part of AAA domain; Region: AAA_19; pfam13245 634500012880 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 634500012881 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 634500012882 Family description; Region: UvrD_C_2; pfam13538 634500012883 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 634500012884 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 634500012885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 634500012886 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 634500012887 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 634500012888 Predicted permeases [General function prediction only]; Region: COG0795 634500012889 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 634500012890 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 634500012891 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 634500012892 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 634500012893 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 634500012894 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 634500012895 active site 634500012896 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 634500012897 active site 634500012898 thymidylate kinase; Region: DTMP_kinase; TIGR00041 634500012899 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 634500012900 active site 634500012901 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 634500012902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 634500012903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500012904 catalytic residue [active] 634500012905 Phosphopantetheine attachment site; Region: PP-binding; cl09936 634500012906 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 634500012907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500012908 NAD(P) binding site [chemical binding]; other site 634500012909 active site 634500012910 acyl-CoA synthetase; Validated; Region: PRK09192 634500012911 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 634500012912 acyl-activating enzyme (AAE) consensus motif; other site 634500012913 active site 634500012914 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 634500012915 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 634500012916 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 634500012917 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500012918 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 634500012919 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 634500012920 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 634500012921 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 634500012922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500012923 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500012924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500012925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500012926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500012927 dimerization interface [polypeptide binding]; other site 634500012928 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 634500012929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500012930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500012931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 634500012932 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 634500012933 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 634500012934 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500012935 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500012936 Walker A/P-loop; other site 634500012937 ATP binding site [chemical binding]; other site 634500012938 Q-loop/lid; other site 634500012939 ABC transporter signature motif; other site 634500012940 Walker B; other site 634500012941 D-loop; other site 634500012942 H-loop/switch region; other site 634500012943 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500012944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500012945 substrate binding pocket [chemical binding]; other site 634500012946 membrane-bound complex binding site; other site 634500012947 hinge residues; other site 634500012948 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012950 dimer interface [polypeptide binding]; other site 634500012951 conserved gate region; other site 634500012952 putative PBP binding loops; other site 634500012953 ABC-ATPase subunit interface; other site 634500012954 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012956 dimer interface [polypeptide binding]; other site 634500012957 conserved gate region; other site 634500012958 putative PBP binding loops; other site 634500012959 ABC-ATPase subunit interface; other site 634500012960 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 634500012961 Autotransporter beta-domain; Region: Autotransporter; pfam03797 634500012962 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500012963 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 634500012964 Walker A/P-loop; other site 634500012965 ATP binding site [chemical binding]; other site 634500012966 Q-loop/lid; other site 634500012967 ABC transporter signature motif; other site 634500012968 Walker B; other site 634500012969 D-loop; other site 634500012970 H-loop/switch region; other site 634500012971 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 634500012972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012973 dimer interface [polypeptide binding]; other site 634500012974 conserved gate region; other site 634500012975 ABC-ATPase subunit interface; other site 634500012976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012977 dimer interface [polypeptide binding]; other site 634500012978 conserved gate region; other site 634500012979 putative PBP binding loops; other site 634500012980 ABC-ATPase subunit interface; other site 634500012981 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500012982 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 634500012983 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500012984 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500012985 Walker A/P-loop; other site 634500012986 ATP binding site [chemical binding]; other site 634500012987 Q-loop/lid; other site 634500012988 ABC transporter signature motif; other site 634500012989 Walker B; other site 634500012990 D-loop; other site 634500012991 H-loop/switch region; other site 634500012992 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500012994 dimer interface [polypeptide binding]; other site 634500012995 conserved gate region; other site 634500012996 putative PBP binding loops; other site 634500012997 ABC-ATPase subunit interface; other site 634500012998 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500012999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500013000 dimer interface [polypeptide binding]; other site 634500013001 conserved gate region; other site 634500013002 putative PBP binding loops; other site 634500013003 ABC-ATPase subunit interface; other site 634500013004 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 634500013005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500013006 NAD(P) binding site [chemical binding]; other site 634500013007 active site 634500013008 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 634500013009 putative active site [active] 634500013010 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634500013011 carboxyltransferase (CT) interaction site; other site 634500013012 biotinylation site [posttranslational modification]; other site 634500013013 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 634500013014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013015 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 634500013016 putative dimerization interface [polypeptide binding]; other site 634500013017 aspartate aminotransferase; Provisional; Region: PRK05764 634500013018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500013019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500013020 homodimer interface [polypeptide binding]; other site 634500013021 catalytic residue [active] 634500013022 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 634500013023 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 634500013024 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 634500013025 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500013026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500013027 substrate binding pocket [chemical binding]; other site 634500013028 membrane-bound complex binding site; other site 634500013029 hinge residues; other site 634500013030 EamA-like transporter family; Region: EamA; pfam00892 634500013031 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 634500013032 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 634500013033 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 634500013034 active site 634500013035 FMN binding site [chemical binding]; other site 634500013036 substrate binding site [chemical binding]; other site 634500013037 homotetramer interface [polypeptide binding]; other site 634500013038 catalytic residue [active] 634500013039 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 634500013040 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 634500013041 active site 634500013042 dimer interface [polypeptide binding]; other site 634500013043 non-prolyl cis peptide bond; other site 634500013044 insertion regions; other site 634500013045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 634500013046 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500013047 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 634500013048 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500013049 substrate binding pocket [chemical binding]; other site 634500013050 membrane-bound complex binding site; other site 634500013051 hinge residues; other site 634500013052 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 634500013053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013054 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 634500013055 putative substrate binding pocket [chemical binding]; other site 634500013056 putative dimerization interface [polypeptide binding]; other site 634500013057 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 634500013058 putative hydrophobic ligand binding site [chemical binding]; other site 634500013059 penicillin-binding protein 2; Provisional; Region: PRK10795 634500013060 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 634500013061 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 634500013062 CHASE4 domain; Region: CHASE4; cl01308 634500013063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500013064 metal binding site [ion binding]; metal-binding site 634500013065 active site 634500013066 I-site; other site 634500013067 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500013068 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 634500013069 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 634500013070 Walker A/P-loop; other site 634500013071 ATP binding site [chemical binding]; other site 634500013072 Q-loop/lid; other site 634500013073 ABC transporter signature motif; other site 634500013074 Walker B; other site 634500013075 D-loop; other site 634500013076 H-loop/switch region; other site 634500013077 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 634500013078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 634500013079 ABC-ATPase subunit interface; other site 634500013080 dimer interface [polypeptide binding]; other site 634500013081 putative PBP binding regions; other site 634500013082 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 634500013083 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500013084 putative hemin binding site; other site 634500013085 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 634500013086 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 634500013087 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 634500013088 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 634500013089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500013090 N-terminal plug; other site 634500013091 ligand-binding site [chemical binding]; other site 634500013092 Rdx family; Region: Rdx; cl01407 634500013093 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500013094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013095 putative substrate translocation pore; other site 634500013096 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500013097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013098 putative substrate translocation pore; other site 634500013099 Cupin; Region: Cupin_6; pfam12852 634500013100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500013101 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500013102 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500013103 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 634500013104 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 634500013105 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 634500013106 active site 634500013107 dimer interface [polypeptide binding]; other site 634500013108 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 634500013109 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 634500013110 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 634500013111 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 634500013112 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 634500013113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 634500013114 FeS/SAM binding site; other site 634500013115 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 634500013116 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 634500013117 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 634500013118 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634500013119 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634500013120 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 634500013121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013122 putative substrate translocation pore; other site 634500013123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013124 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 634500013125 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 634500013126 dimer interface [polypeptide binding]; other site 634500013127 ligand binding site [chemical binding]; other site 634500013128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500013129 dimerization interface [polypeptide binding]; other site 634500013130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500013131 dimer interface [polypeptide binding]; other site 634500013132 putative CheW interface [polypeptide binding]; other site 634500013133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500013134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013135 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500013136 putative effector binding pocket; other site 634500013137 dimerization interface [polypeptide binding]; other site 634500013138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 634500013139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013140 putative substrate translocation pore; other site 634500013141 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 634500013142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500013143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500013144 non-specific DNA binding site [nucleotide binding]; other site 634500013145 salt bridge; other site 634500013146 sequence-specific DNA binding site [nucleotide binding]; other site 634500013147 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 634500013148 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 634500013149 active site 634500013150 P-loop; other site 634500013151 phosphorylation site [posttranslational modification] 634500013152 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 634500013153 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 634500013154 active site 634500013155 ADP/pyrophosphate binding site [chemical binding]; other site 634500013156 dimerization interface [polypeptide binding]; other site 634500013157 allosteric effector site; other site 634500013158 fructose-1,6-bisphosphate binding site; other site 634500013159 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500013160 active site 634500013161 phosphorylation site [posttranslational modification] 634500013162 AAA domain; Region: AAA_33; pfam13671 634500013163 AAA domain; Region: AAA_17; pfam13207 634500013164 Class I aldolases; Region: Aldolase_Class_I; cl17187 634500013165 catalytic residue [active] 634500013166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 634500013167 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 634500013168 DNA binding residues [nucleotide binding] 634500013169 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 634500013170 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 634500013171 Ferritin-like domain; Region: Ferritin; pfam00210 634500013172 ferroxidase diiron center [ion binding]; other site 634500013173 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500013174 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500013175 Cytochrome c; Region: Cytochrom_C; pfam00034 634500013176 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500013177 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500013178 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634500013179 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 634500013180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500013182 dimerization interface [polypeptide binding]; other site 634500013183 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 634500013184 amidohydrolase; Region: amidohydrolases; TIGR01891 634500013185 putative metal binding site [ion binding]; other site 634500013186 dimer interface [polypeptide binding]; other site 634500013187 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 634500013188 amidohydrolase; Region: amidohydrolases; TIGR01891 634500013189 putative metal binding site [ion binding]; other site 634500013190 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 634500013191 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 634500013192 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 634500013193 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 634500013194 active site 634500013195 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 634500013196 Cupin; Region: Cupin_1; smart00835 634500013197 Cupin; Region: Cupin_1; smart00835 634500013198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 634500013199 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 634500013200 putative acyl-acceptor binding pocket; other site 634500013201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 634500013202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 634500013203 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 634500013204 Fatty acid desaturase; Region: FA_desaturase; pfam00487 634500013205 putative di-iron ligands [ion binding]; other site 634500013206 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 634500013207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634500013208 Beta-lactamase; Region: Beta-lactamase; pfam00144 634500013209 PAAR motif; Region: PAAR_motif; pfam05488 634500013210 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 634500013211 RHS Repeat; Region: RHS_repeat; pfam05593 634500013212 RHS Repeat; Region: RHS_repeat; pfam05593 634500013213 RHS Repeat; Region: RHS_repeat; pfam05593 634500013214 RHS protein; Region: RHS; pfam03527 634500013215 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 634500013216 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 634500013217 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 634500013218 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 634500013219 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 634500013220 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 634500013221 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 634500013222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 634500013223 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 634500013224 Uncharacterized conserved protein [Function unknown]; Region: COG2308 634500013225 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 634500013226 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 634500013227 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 634500013228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500013229 DNA-binding site [nucleotide binding]; DNA binding site 634500013230 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500013231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500013232 homodimer interface [polypeptide binding]; other site 634500013233 catalytic residue [active] 634500013234 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 634500013235 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 634500013236 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 634500013237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 634500013238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500013239 metal binding site [ion binding]; metal-binding site 634500013240 active site 634500013241 I-site; other site 634500013242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500013243 Spore Coat Protein U domain; Region: SCPU; pfam05229 634500013244 Spore Coat Protein U domain; Region: SCPU; pfam05229 634500013245 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 634500013246 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 634500013247 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 634500013248 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500013249 PapC C-terminal domain; Region: PapC_C; pfam13953 634500013250 Spore Coat Protein U domain; Region: SCPU; pfam05229 634500013251 citrate-proton symporter; Provisional; Region: PRK15075 634500013252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013253 putative substrate translocation pore; other site 634500013254 biopolymer transport protein ExbD; Provisional; Region: PRK11267 634500013255 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 634500013256 biopolymer transport protein ExbB; Provisional; Region: PRK10414 634500013257 cystathionine beta-lyase; Provisional; Region: PRK08114 634500013258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 634500013259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500013260 catalytic residue [active] 634500013261 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 634500013262 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 634500013263 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 634500013264 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 634500013265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500013266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500013267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 634500013268 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 634500013269 active site 634500013270 catalytic tetrad [active] 634500013271 FtsI repressor; Provisional; Region: PRK10883 634500013272 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 634500013273 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 634500013274 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 634500013275 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 634500013276 putative acyl-acceptor binding pocket; other site 634500013277 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 634500013278 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 634500013279 CAP-like domain; other site 634500013280 active site 634500013281 primary dimer interface [polypeptide binding]; other site 634500013282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500013283 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500013284 substrate binding pocket [chemical binding]; other site 634500013285 membrane-bound complex binding site; other site 634500013286 hinge residues; other site 634500013287 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 634500013288 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 634500013289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500013290 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 634500013291 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 634500013292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500013293 Walker A/P-loop; other site 634500013294 ATP binding site [chemical binding]; other site 634500013295 Q-loop/lid; other site 634500013296 ABC transporter signature motif; other site 634500013297 Walker B; other site 634500013298 D-loop; other site 634500013299 H-loop/switch region; other site 634500013300 TOBE domain; Region: TOBE_2; pfam08402 634500013301 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 634500013302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500013303 dimer interface [polypeptide binding]; other site 634500013304 conserved gate region; other site 634500013305 putative PBP binding loops; other site 634500013306 ABC-ATPase subunit interface; other site 634500013307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500013308 dimer interface [polypeptide binding]; other site 634500013309 conserved gate region; other site 634500013310 putative PBP binding loops; other site 634500013311 ABC-ATPase subunit interface; other site 634500013312 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 634500013313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 634500013314 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 634500013315 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 634500013316 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 634500013317 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 634500013318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500013319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013320 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 634500013321 putative substrate binding pocket [chemical binding]; other site 634500013322 dimerization interface [polypeptide binding]; other site 634500013323 acetylornithine deacetylase; Provisional; Region: PRK07522 634500013324 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 634500013325 metal binding site [ion binding]; metal-binding site 634500013326 putative dimer interface [polypeptide binding]; other site 634500013327 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 634500013328 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500013329 homotrimer interaction site [polypeptide binding]; other site 634500013330 putative active site [active] 634500013331 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 634500013332 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 634500013333 active site 634500013334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500013335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500013337 dimerization interface [polypeptide binding]; other site 634500013338 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 634500013339 Domain of unknown function (DUF336); Region: DUF336; cl01249 634500013340 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 634500013341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500013342 active site 634500013343 phosphorylation site [posttranslational modification] 634500013344 intermolecular recognition site; other site 634500013345 dimerization interface [polypeptide binding]; other site 634500013346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500013347 DNA binding residues [nucleotide binding] 634500013348 dimerization interface [polypeptide binding]; other site 634500013349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500013350 dimer interface [polypeptide binding]; other site 634500013351 phosphorylation site [posttranslational modification] 634500013352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500013353 ATP binding site [chemical binding]; other site 634500013354 Mg2+ binding site [ion binding]; other site 634500013355 G-X-G motif; other site 634500013356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634500013357 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 634500013358 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 634500013359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500013360 ATP binding site [chemical binding]; other site 634500013361 Mg2+ binding site [ion binding]; other site 634500013362 G-X-G motif; other site 634500013363 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 634500013364 anchoring element; other site 634500013365 dimer interface [polypeptide binding]; other site 634500013366 ATP binding site [chemical binding]; other site 634500013367 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 634500013368 active site 634500013369 metal binding site [ion binding]; metal-binding site 634500013370 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 634500013371 esterase YqiA; Provisional; Region: PRK11071 634500013372 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 634500013373 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 634500013374 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 634500013375 active site 634500013376 metal binding site [ion binding]; metal-binding site 634500013377 hexamer interface [polypeptide binding]; other site 634500013378 putative dehydrogenase; Provisional; Region: PRK11039 634500013379 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 634500013380 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 634500013381 dimer interface [polypeptide binding]; other site 634500013382 ADP-ribose binding site [chemical binding]; other site 634500013383 active site 634500013384 nudix motif; other site 634500013385 metal binding site [ion binding]; metal-binding site 634500013386 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 634500013387 hypothetical protein; Provisional; Region: PRK11653 634500013388 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 634500013389 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 634500013390 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013391 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013392 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013393 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013394 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013395 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013396 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013397 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013398 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013399 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013400 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013401 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013402 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013403 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013404 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013405 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013406 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013407 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013408 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 634500013409 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 634500013410 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 634500013411 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 634500013412 putative active site [active] 634500013413 metal binding site [ion binding]; metal-binding site 634500013414 zinc transporter ZupT; Provisional; Region: PRK04201 634500013415 ZIP Zinc transporter; Region: Zip; pfam02535 634500013416 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 634500013417 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 634500013418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 634500013419 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 634500013420 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 634500013421 putative ribose interaction site [chemical binding]; other site 634500013422 putative ADP binding site [chemical binding]; other site 634500013423 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 634500013424 active site 634500013425 nucleotide binding site [chemical binding]; other site 634500013426 HIGH motif; other site 634500013427 KMSKS motif; other site 634500013428 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 634500013429 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 634500013430 metal binding triad; other site 634500013431 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 634500013432 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 634500013433 metal binding triad; other site 634500013434 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 634500013435 Uncharacterized conserved protein [Function unknown]; Region: COG3025 634500013436 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 634500013437 putative active site [active] 634500013438 putative metal binding residues [ion binding]; other site 634500013439 signature motif; other site 634500013440 putative triphosphate binding site [ion binding]; other site 634500013441 SH3 domain-containing protein; Provisional; Region: PRK10884 634500013442 Bacterial SH3 domain homologues; Region: SH3b; smart00287 634500013443 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 634500013444 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 634500013445 active site 634500013446 NTP binding site [chemical binding]; other site 634500013447 metal binding triad [ion binding]; metal-binding site 634500013448 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 634500013449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 634500013450 Zn2+ binding site [ion binding]; other site 634500013451 Mg2+ binding site [ion binding]; other site 634500013452 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 634500013453 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 634500013454 homooctamer interface [polypeptide binding]; other site 634500013455 active site 634500013456 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 634500013457 UGMP family protein; Validated; Region: PRK09604 634500013458 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 634500013459 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 634500013460 DNA primase; Validated; Region: dnaG; PRK05667 634500013461 CHC2 zinc finger; Region: zf-CHC2; pfam01807 634500013462 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 634500013463 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 634500013464 active site 634500013465 metal binding site [ion binding]; metal-binding site 634500013466 interdomain interaction site; other site 634500013467 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 634500013468 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 634500013469 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 634500013470 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 634500013471 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 634500013472 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 634500013473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500013474 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 634500013475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500013476 DNA binding residues [nucleotide binding] 634500013477 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 634500013478 active site 634500013479 SUMO-1 interface [polypeptide binding]; other site 634500013480 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 634500013481 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 634500013482 structural tetrad; other site 634500013483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 634500013484 Domain of unknown function (DUF336); Region: DUF336; cl01249 634500013485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500013486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500013487 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500013488 putative effector binding pocket; other site 634500013489 dimerization interface [polypeptide binding]; other site 634500013490 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 634500013491 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 634500013492 Amidase; Region: Amidase; pfam01425 634500013493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 634500013494 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 634500013495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 634500013496 catalytic residue [active] 634500013497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 634500013498 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 634500013499 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 634500013500 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 634500013501 Class I aldolases; Region: Aldolase_Class_I; cl17187 634500013502 catalytic residue [active] 634500013503 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 634500013504 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 634500013505 putative N- and C-terminal domain interface [polypeptide binding]; other site 634500013506 putative active site [active] 634500013507 MgATP binding site [chemical binding]; other site 634500013508 catalytic site [active] 634500013509 metal binding site [ion binding]; metal-binding site 634500013510 putative xylulose binding site [chemical binding]; other site 634500013511 phosphoglycerol transferase I; Provisional; Region: PRK03776 634500013512 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 634500013513 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 634500013514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500013515 dimerization interface [polypeptide binding]; other site 634500013516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500013517 dimer interface [polypeptide binding]; other site 634500013518 putative CheW interface [polypeptide binding]; other site 634500013519 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 634500013520 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634500013521 amino acid transporter; Region: 2A0306; TIGR00909 634500013522 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 634500013523 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 634500013524 dimer interface [polypeptide binding]; other site 634500013525 active site 634500013526 metal binding site [ion binding]; metal-binding site 634500013527 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500013528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500013529 DNA binding site [nucleotide binding] 634500013530 domain linker motif; other site 634500013531 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 634500013532 dimerization interface [polypeptide binding]; other site 634500013533 ligand binding site [chemical binding]; other site 634500013534 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500013535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500013536 substrate binding pocket [chemical binding]; other site 634500013537 membrane-bound complex binding site; other site 634500013538 hinge residues; other site 634500013539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500013540 dimer interface [polypeptide binding]; other site 634500013541 conserved gate region; other site 634500013542 putative PBP binding loops; other site 634500013543 ABC-ATPase subunit interface; other site 634500013544 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500013545 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500013546 Walker A/P-loop; other site 634500013547 ATP binding site [chemical binding]; other site 634500013548 Q-loop/lid; other site 634500013549 ABC transporter signature motif; other site 634500013550 Walker B; other site 634500013551 D-loop; other site 634500013552 H-loop/switch region; other site 634500013553 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 634500013554 aspartate aminotransferase; Provisional; Region: PRK06107 634500013555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500013556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500013557 homodimer interface [polypeptide binding]; other site 634500013558 catalytic residue [active] 634500013559 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 634500013560 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 634500013561 active site 634500013562 non-prolyl cis peptide bond; other site 634500013563 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 634500013564 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 634500013565 putative active site [active] 634500013566 metal binding site [ion binding]; metal-binding site 634500013567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 634500013568 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 634500013569 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 634500013570 metal binding site [ion binding]; metal-binding site 634500013571 dimer interface [polypeptide binding]; other site 634500013572 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 634500013573 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 634500013574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500013575 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 634500013576 molybdopterin cofactor binding site; other site 634500013577 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 634500013578 molybdopterin cofactor binding site; other site 634500013579 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500013580 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500013581 Walker A/P-loop; other site 634500013582 ATP binding site [chemical binding]; other site 634500013583 Q-loop/lid; other site 634500013584 ABC transporter signature motif; other site 634500013585 Walker B; other site 634500013586 D-loop; other site 634500013587 H-loop/switch region; other site 634500013588 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 634500013589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500013590 dimer interface [polypeptide binding]; other site 634500013591 conserved gate region; other site 634500013592 putative PBP binding loops; other site 634500013593 ABC-ATPase subunit interface; other site 634500013594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500013595 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500013596 substrate binding pocket [chemical binding]; other site 634500013597 membrane-bound complex binding site; other site 634500013598 hinge residues; other site 634500013599 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 634500013600 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500013601 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500013602 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500013603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500013604 Cytochrome c; Region: Cytochrom_C; pfam00034 634500013605 Domain of unknown function (DUF386); Region: DUF386; cl01047 634500013606 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 634500013607 ATP-binding site [chemical binding]; other site 634500013608 Gluconate-6-phosphate binding site [chemical binding]; other site 634500013609 Shikimate kinase; Region: SKI; pfam01202 634500013610 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 634500013611 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 634500013612 NADP binding site [chemical binding]; other site 634500013613 homodimer interface [polypeptide binding]; other site 634500013614 active site 634500013615 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 634500013616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500013617 DNA binding site [nucleotide binding] 634500013618 domain linker motif; other site 634500013619 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 634500013620 putative ligand binding site [chemical binding]; other site 634500013621 putative dimerization interface [polypeptide binding]; other site 634500013622 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 634500013623 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634500013624 putative ligand binding site [chemical binding]; other site 634500013625 NAD binding site [chemical binding]; other site 634500013626 catalytic site [active] 634500013627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013628 D-galactonate transporter; Region: 2A0114; TIGR00893 634500013629 putative substrate translocation pore; other site 634500013630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500013631 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 634500013632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500013633 ligand binding site [chemical binding]; other site 634500013634 Fusaric acid resistance protein family; Region: FUSC; pfam04632 634500013635 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500013636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 634500013637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500013638 non-specific DNA binding site [nucleotide binding]; other site 634500013639 salt bridge; other site 634500013640 sequence-specific DNA binding site [nucleotide binding]; other site 634500013641 RES domain; Region: RES; pfam08808 634500013642 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 634500013643 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 634500013644 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 634500013645 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 634500013646 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 634500013647 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 634500013648 PAAR motif; Region: PAAR_motif; pfam05488 634500013649 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 634500013650 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 634500013651 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 634500013652 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 634500013653 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 634500013654 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 634500013655 HNH endonuclease; Region: HNH_2; pfam13391 634500013656 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 634500013657 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 634500013658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500013659 ATP binding site [chemical binding]; other site 634500013660 putative Mg++ binding site [ion binding]; other site 634500013661 HsdM N-terminal domain; Region: HsdM_N; pfam12161 634500013662 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 634500013663 Methyltransferase domain; Region: Methyltransf_26; pfam13659 634500013664 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 634500013665 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634500013666 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 634500013667 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 634500013668 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 634500013669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 634500013670 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 634500013671 Toprim domain; Region: Toprim_3; pfam13362 634500013672 active site 634500013673 metal binding site [ion binding]; metal-binding site 634500013674 D5 N terminal like; Region: D5_N; smart00885 634500013675 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 634500013676 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 634500013677 Ash protein family; Region: Phage_ASH; pfam10554 634500013678 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 634500013679 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 634500013680 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 634500013681 TIR domain; Region: TIR_2; pfam13676 634500013682 integrase; Provisional; Region: PRK09692 634500013683 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 634500013684 active site 634500013685 Int/Topo IB signature motif; other site 634500013686 hypothetical protein; Provisional; Region: PRK11667 634500013687 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 634500013688 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 634500013689 Walker A motif; other site 634500013690 ATP binding site [chemical binding]; other site 634500013691 Predicted membrane protein [Function unknown]; Region: COG2733 634500013692 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 634500013693 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 634500013694 Autotransporter beta-domain; Region: Autotransporter; pfam03797 634500013695 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 634500013696 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 634500013697 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 634500013698 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 634500013699 multifunctional aminopeptidase A; Provisional; Region: PRK00913 634500013700 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 634500013701 interface (dimer of trimers) [polypeptide binding]; other site 634500013702 Substrate-binding/catalytic site; other site 634500013703 Zn-binding sites [ion binding]; other site 634500013704 DNA polymerase III subunit chi; Validated; Region: PRK05728 634500013705 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 634500013706 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 634500013707 HIGH motif; other site 634500013708 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 634500013709 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 634500013710 active site 634500013711 KMSKS motif; other site 634500013712 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 634500013713 tRNA binding surface [nucleotide binding]; other site 634500013714 anticodon binding site; other site 634500013715 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 634500013716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 634500013717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500013718 Coenzyme A binding pocket [chemical binding]; other site 634500013719 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 634500013720 active site 634500013721 dinuclear metal binding site [ion binding]; other site 634500013722 dimerization interface [polypeptide binding]; other site 634500013723 RNase E inhibitor protein; Provisional; Region: PRK11191 634500013724 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 634500013725 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 634500013726 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 634500013727 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 634500013728 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 634500013729 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 634500013730 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 634500013731 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 634500013732 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 634500013733 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500013734 homotrimer interaction site [polypeptide binding]; other site 634500013735 putative active site [active] 634500013736 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 634500013737 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 634500013738 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 634500013739 active site 634500013740 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 634500013741 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 634500013742 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 634500013743 Ca binding site [ion binding]; other site 634500013744 active site 634500013745 catalytic site [active] 634500013746 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 634500013747 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 634500013748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 634500013749 ATP binding site [chemical binding]; other site 634500013750 putative Mg++ binding site [ion binding]; other site 634500013751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500013752 nucleotide binding region [chemical binding]; other site 634500013753 ATP-binding site [chemical binding]; other site 634500013754 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 634500013755 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 634500013756 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 634500013757 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 634500013758 NAD binding site [chemical binding]; other site 634500013759 sugar binding site [chemical binding]; other site 634500013760 divalent metal binding site [ion binding]; other site 634500013761 tetramer (dimer of dimers) interface [polypeptide binding]; other site 634500013762 dimer interface [polypeptide binding]; other site 634500013763 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 634500013764 methionine cluster; other site 634500013765 active site 634500013766 phosphorylation site [posttranslational modification] 634500013767 metal binding site [ion binding]; metal-binding site 634500013768 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 634500013769 active site 634500013770 P-loop; other site 634500013771 phosphorylation site [posttranslational modification] 634500013772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500013773 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634500013774 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500013775 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500013776 putative active site [active] 634500013777 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 634500013778 ATP cone domain; Region: ATP-cone; pfam03477 634500013779 Class III ribonucleotide reductase; Region: RNR_III; cd01675 634500013780 effector binding site; other site 634500013781 active site 634500013782 Zn binding site [ion binding]; other site 634500013783 glycine loop; other site 634500013784 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 634500013785 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 634500013786 Predicted permease; Region: DUF318; pfam03773 634500013787 intracellular protease, PfpI family; Region: PfpI; TIGR01382 634500013788 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 634500013789 proposed catalytic triad [active] 634500013790 conserved cys residue [active] 634500013791 hypothetical protein; Provisional; Region: PRK03467 634500013792 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 634500013793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500013794 Coenzyme A binding pocket [chemical binding]; other site 634500013795 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 634500013796 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 634500013797 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 634500013798 Peptidase family U32; Region: Peptidase_U32; pfam01136 634500013799 putative protease; Provisional; Region: PRK15447 634500013800 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 634500013801 hypothetical protein; Provisional; Region: PRK10508 634500013802 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 634500013803 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 634500013804 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 634500013805 ATP binding site [chemical binding]; other site 634500013806 Mg++ binding site [ion binding]; other site 634500013807 motif III; other site 634500013808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 634500013809 nucleotide binding region [chemical binding]; other site 634500013810 ATP-binding site [chemical binding]; other site 634500013811 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 634500013812 putative RNA binding site [nucleotide binding]; other site 634500013813 lipoprotein NlpI; Provisional; Region: PRK11189 634500013814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500013815 binding surface 634500013816 TPR motif; other site 634500013817 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 634500013818 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 634500013819 RNase E interface [polypeptide binding]; other site 634500013820 trimer interface [polypeptide binding]; other site 634500013821 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 634500013822 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 634500013823 RNase E interface [polypeptide binding]; other site 634500013824 trimer interface [polypeptide binding]; other site 634500013825 active site 634500013826 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 634500013827 putative nucleic acid binding region [nucleotide binding]; other site 634500013828 G-X-X-G motif; other site 634500013829 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 634500013830 RNA binding site [nucleotide binding]; other site 634500013831 domain interface; other site 634500013832 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 634500013833 16S/18S rRNA binding site [nucleotide binding]; other site 634500013834 S13e-L30e interaction site [polypeptide binding]; other site 634500013835 25S rRNA binding site [nucleotide binding]; other site 634500013836 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 634500013837 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 634500013838 RNA binding site [nucleotide binding]; other site 634500013839 active site 634500013840 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 634500013841 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 634500013842 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 634500013843 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 634500013844 translation initiation factor IF-2; Region: IF-2; TIGR00487 634500013845 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 634500013846 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 634500013847 G1 box; other site 634500013848 putative GEF interaction site [polypeptide binding]; other site 634500013849 GTP/Mg2+ binding site [chemical binding]; other site 634500013850 Switch I region; other site 634500013851 G2 box; other site 634500013852 G3 box; other site 634500013853 Switch II region; other site 634500013854 G4 box; other site 634500013855 G5 box; other site 634500013856 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 634500013857 Translation-initiation factor 2; Region: IF-2; pfam11987 634500013858 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 634500013859 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 634500013860 NusA N-terminal domain; Region: NusA_N; pfam08529 634500013861 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 634500013862 RNA binding site [nucleotide binding]; other site 634500013863 homodimer interface [polypeptide binding]; other site 634500013864 NusA-like KH domain; Region: KH_5; pfam13184 634500013865 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 634500013866 G-X-X-G motif; other site 634500013867 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 634500013868 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 634500013869 ribosome maturation protein RimP; Reviewed; Region: PRK00092 634500013870 Sm and related proteins; Region: Sm_like; cl00259 634500013871 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 634500013872 putative oligomer interface [polypeptide binding]; other site 634500013873 putative RNA binding site [nucleotide binding]; other site 634500013874 Preprotein translocase SecG subunit; Region: SecG; pfam03840 634500013875 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 634500013876 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 634500013877 active site 634500013878 substrate binding site [chemical binding]; other site 634500013879 metal binding site [ion binding]; metal-binding site 634500013880 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 634500013881 dihydropteroate synthase; Region: DHPS; TIGR01496 634500013882 substrate binding pocket [chemical binding]; other site 634500013883 dimer interface [polypeptide binding]; other site 634500013884 inhibitor binding site; inhibition site 634500013885 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 634500013886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500013887 Walker A motif; other site 634500013888 ATP binding site [chemical binding]; other site 634500013889 Walker B motif; other site 634500013890 arginine finger; other site 634500013891 Peptidase family M41; Region: Peptidase_M41; pfam01434 634500013892 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 634500013893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500013894 S-adenosylmethionine binding site [chemical binding]; other site 634500013895 RNA-binding protein YhbY; Provisional; Region: PRK10343 634500013896 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 634500013897 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 634500013898 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 634500013899 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 634500013900 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 634500013901 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 634500013902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500013903 active site 634500013904 phosphorylation site [posttranslational modification] 634500013905 intermolecular recognition site; other site 634500013906 dimerization interface [polypeptide binding]; other site 634500013907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500013908 DNA binding site [nucleotide binding] 634500013909 sensor protein BasS/PmrB; Provisional; Region: PRK10755 634500013910 HAMP domain; Region: HAMP; pfam00672 634500013911 dimerization interface [polypeptide binding]; other site 634500013912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 634500013913 dimer interface [polypeptide binding]; other site 634500013914 phosphorylation site [posttranslational modification] 634500013915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500013916 ATP binding site [chemical binding]; other site 634500013917 Mg2+ binding site [ion binding]; other site 634500013918 G-X-G motif; other site 634500013919 outer membrane receptor FepA; Provisional; Region: PRK13524 634500013920 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500013921 N-terminal plug; other site 634500013922 ligand-binding site [chemical binding]; other site 634500013923 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 634500013924 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 634500013925 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 634500013926 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 634500013927 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634500013928 intersubunit interface [polypeptide binding]; other site 634500013929 GTPase CgtA; Reviewed; Region: obgE; PRK12298 634500013930 GTP1/OBG; Region: GTP1_OBG; pfam01018 634500013931 Obg GTPase; Region: Obg; cd01898 634500013932 G1 box; other site 634500013933 GTP/Mg2+ binding site [chemical binding]; other site 634500013934 Switch I region; other site 634500013935 G2 box; other site 634500013936 G3 box; other site 634500013937 Switch II region; other site 634500013938 G4 box; other site 634500013939 G5 box; other site 634500013940 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 634500013941 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 634500013942 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 634500013943 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 634500013944 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 634500013945 substrate binding pocket [chemical binding]; other site 634500013946 chain length determination region; other site 634500013947 substrate-Mg2+ binding site; other site 634500013948 catalytic residues [active] 634500013949 aspartate-rich region 1; other site 634500013950 active site lid residues [active] 634500013951 aspartate-rich region 2; other site 634500013952 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 634500013953 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 634500013954 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 634500013955 hinge; other site 634500013956 active site 634500013957 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 634500013958 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 634500013959 anti sigma factor interaction site; other site 634500013960 regulatory phosphorylation site [posttranslational modification]; other site 634500013961 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 634500013962 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 634500013963 mce related protein; Region: MCE; pfam02470 634500013964 conserved hypothetical integral membrane protein; Region: TIGR00056 634500013965 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 634500013966 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 634500013967 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 634500013968 Walker A/P-loop; other site 634500013969 ATP binding site [chemical binding]; other site 634500013970 Q-loop/lid; other site 634500013971 ABC transporter signature motif; other site 634500013972 Walker B; other site 634500013973 D-loop; other site 634500013974 H-loop/switch region; other site 634500013975 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 634500013976 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 634500013977 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 634500013978 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 634500013979 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 634500013980 putative active site [active] 634500013981 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 634500013982 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 634500013983 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 634500013984 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 634500013985 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 634500013986 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 634500013987 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 634500013988 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 634500013989 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 634500013990 Walker A/P-loop; other site 634500013991 ATP binding site [chemical binding]; other site 634500013992 Q-loop/lid; other site 634500013993 ABC transporter signature motif; other site 634500013994 Walker B; other site 634500013995 D-loop; other site 634500013996 H-loop/switch region; other site 634500013997 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 634500013998 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 634500013999 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 634500014000 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 634500014001 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 634500014002 30S subunit binding site; other site 634500014003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500014004 active site 634500014005 phosphorylation site [posttranslational modification] 634500014006 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 634500014007 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 634500014008 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 634500014009 dimerization domain swap beta strand [polypeptide binding]; other site 634500014010 regulatory protein interface [polypeptide binding]; other site 634500014011 active site 634500014012 regulatory phosphorylation site [posttranslational modification]; other site 634500014013 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 634500014014 Transglycosylase; Region: Transgly; cl17702 634500014015 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 634500014016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 634500014017 putative active site [active] 634500014018 heme pocket [chemical binding]; other site 634500014019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500014020 dimer interface [polypeptide binding]; other site 634500014021 phosphorylation site [posttranslational modification] 634500014022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500014023 ATP binding site [chemical binding]; other site 634500014024 Mg2+ binding site [ion binding]; other site 634500014025 G-X-G motif; other site 634500014026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500014027 active site 634500014028 phosphorylation site [posttranslational modification] 634500014029 intermolecular recognition site; other site 634500014030 dimerization interface [polypeptide binding]; other site 634500014031 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 634500014032 putative binding surface; other site 634500014033 active site 634500014034 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 634500014035 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 634500014036 active site 634500014037 dimer interface [polypeptide binding]; other site 634500014038 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 634500014039 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 634500014040 active site 634500014041 FMN binding site [chemical binding]; other site 634500014042 substrate binding site [chemical binding]; other site 634500014043 3Fe-4S cluster binding site [ion binding]; other site 634500014044 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 634500014045 domain_subunit interface; other site 634500014046 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 634500014047 Flavodoxin; Region: Flavodoxin_1; pfam00258 634500014048 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 634500014049 FAD binding pocket [chemical binding]; other site 634500014050 FAD binding motif [chemical binding]; other site 634500014051 catalytic residues [active] 634500014052 NAD binding pocket [chemical binding]; other site 634500014053 phosphate binding motif [ion binding]; other site 634500014054 beta-alpha-beta structure motif; other site 634500014055 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 634500014056 stringent starvation protein A; Provisional; Region: sspA; PRK09481 634500014057 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 634500014058 C-terminal domain interface [polypeptide binding]; other site 634500014059 putative GSH binding site (G-site) [chemical binding]; other site 634500014060 dimer interface [polypeptide binding]; other site 634500014061 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 634500014062 dimer interface [polypeptide binding]; other site 634500014063 N-terminal domain interface [polypeptide binding]; other site 634500014064 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 634500014065 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 634500014066 23S rRNA interface [nucleotide binding]; other site 634500014067 L3 interface [polypeptide binding]; other site 634500014068 Predicted ATPase [General function prediction only]; Region: COG1485 634500014069 hypothetical protein; Provisional; Region: PRK11677 634500014070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 634500014071 serine endoprotease; Provisional; Region: PRK10139 634500014072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634500014073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634500014074 protein binding site [polypeptide binding]; other site 634500014075 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 634500014076 serine endoprotease; Provisional; Region: PRK10898 634500014077 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 634500014078 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 634500014079 protein binding site [polypeptide binding]; other site 634500014080 malate dehydrogenase; Provisional; Region: PRK05086 634500014081 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 634500014082 NAD binding site [chemical binding]; other site 634500014083 dimerization interface [polypeptide binding]; other site 634500014084 Substrate binding site [chemical binding]; other site 634500014085 arginine repressor; Provisional; Region: PRK05066 634500014086 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 634500014087 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 634500014088 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500014089 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500014090 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 634500014091 RNAase interaction site [polypeptide binding]; other site 634500014092 succinic semialdehyde dehydrogenase; Region: PLN02278 634500014093 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 634500014094 tetramerization interface [polypeptide binding]; other site 634500014095 NAD(P) binding site [chemical binding]; other site 634500014096 catalytic residues [active] 634500014097 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 634500014098 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500014099 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 634500014100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500014101 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500014102 efflux system membrane protein; Provisional; Region: PRK11594 634500014103 transcriptional regulator; Provisional; Region: PRK10632 634500014104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500014105 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 634500014106 putative effector binding pocket; other site 634500014107 dimerization interface [polypeptide binding]; other site 634500014108 protease TldD; Provisional; Region: tldD; PRK10735 634500014109 hypothetical protein; Provisional; Region: PRK10899 634500014110 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 634500014111 ribonuclease G; Provisional; Region: PRK11712 634500014112 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 634500014113 homodimer interface [polypeptide binding]; other site 634500014114 oligonucleotide binding site [chemical binding]; other site 634500014115 Maf-like protein; Region: Maf; pfam02545 634500014116 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 634500014117 active site 634500014118 dimer interface [polypeptide binding]; other site 634500014119 rod shape-determining protein MreD; Provisional; Region: PRK11060 634500014120 rod shape-determining protein MreC; Region: mreC; TIGR00219 634500014121 rod shape-determining protein MreC; Region: MreC; pfam04085 634500014122 rod shape-determining protein MreB; Provisional; Region: PRK13927 634500014123 MreB and similar proteins; Region: MreB_like; cd10225 634500014124 nucleotide binding site [chemical binding]; other site 634500014125 Mg binding site [ion binding]; other site 634500014126 putative protofilament interaction site [polypeptide binding]; other site 634500014127 RodZ interaction site [polypeptide binding]; other site 634500014128 regulatory protein CsrD; Provisional; Region: PRK11059 634500014129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500014130 metal binding site [ion binding]; metal-binding site 634500014131 active site 634500014132 I-site; other site 634500014133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500014134 TMAO/DMSO reductase; Reviewed; Region: PRK05363 634500014135 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 634500014136 Moco binding site; other site 634500014137 metal coordination site [ion binding]; other site 634500014138 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 634500014139 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 634500014140 Dehydroquinase class II; Region: DHquinase_II; pfam01220 634500014141 active site 634500014142 trimer interface [polypeptide binding]; other site 634500014143 dimer interface [polypeptide binding]; other site 634500014144 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 634500014145 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 634500014146 carboxyltransferase (CT) interaction site; other site 634500014147 biotinylation site [posttranslational modification]; other site 634500014148 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 634500014149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 634500014150 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 634500014151 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 634500014152 hypothetical protein; Provisional; Region: PRK10633 634500014153 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 634500014154 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 634500014155 Na binding site [ion binding]; other site 634500014156 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 634500014157 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 634500014158 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 634500014159 FMN binding site [chemical binding]; other site 634500014160 active site 634500014161 catalytic residues [active] 634500014162 substrate binding site [chemical binding]; other site 634500014163 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 634500014164 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 634500014165 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 634500014166 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 634500014167 putative acyl-acceptor binding pocket; other site 634500014168 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 634500014169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500014170 substrate binding pocket [chemical binding]; other site 634500014171 membrane-bound complex binding site; other site 634500014172 hinge residues; other site 634500014173 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 634500014174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014175 conserved gate region; other site 634500014176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014177 dimer interface [polypeptide binding]; other site 634500014178 conserved gate region; other site 634500014179 putative PBP binding loops; other site 634500014180 ABC-ATPase subunit interface; other site 634500014181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014182 dimer interface [polypeptide binding]; other site 634500014183 conserved gate region; other site 634500014184 putative PBP binding loops; other site 634500014185 ABC-ATPase subunit interface; other site 634500014186 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500014187 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 634500014188 Walker A/P-loop; other site 634500014189 ATP binding site [chemical binding]; other site 634500014190 Q-loop/lid; other site 634500014191 ABC transporter signature motif; other site 634500014192 Walker B; other site 634500014193 D-loop; other site 634500014194 H-loop/switch region; other site 634500014195 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 634500014196 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 634500014197 trimer interface [polypeptide binding]; other site 634500014198 putative metal binding site [ion binding]; other site 634500014199 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 634500014200 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 634500014201 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 634500014202 shikimate binding site; other site 634500014203 NAD(P) binding site [chemical binding]; other site 634500014204 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 634500014205 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500014206 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 634500014207 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500014208 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 634500014209 hypothetical protein; Validated; Region: PRK03430 634500014210 hypothetical protein; Provisional; Region: PRK10736 634500014211 DNA protecting protein DprA; Region: dprA; TIGR00732 634500014212 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 634500014213 active site 634500014214 catalytic residues [active] 634500014215 metal binding site [ion binding]; metal-binding site 634500014216 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 634500014217 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 634500014218 putative active site [active] 634500014219 substrate binding site [chemical binding]; other site 634500014220 putative cosubstrate binding site; other site 634500014221 catalytic site [active] 634500014222 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 634500014223 substrate binding site [chemical binding]; other site 634500014224 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 634500014225 putative RNA binding site [nucleotide binding]; other site 634500014226 16S rRNA methyltransferase B; Provisional; Region: PRK10901 634500014227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500014228 S-adenosylmethionine binding site [chemical binding]; other site 634500014229 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 634500014230 TrkA-N domain; Region: TrkA_N; pfam02254 634500014231 TrkA-C domain; Region: TrkA_C; pfam02080 634500014232 TrkA-N domain; Region: TrkA_N; pfam02254 634500014233 TrkA-C domain; Region: TrkA_C; pfam02080 634500014234 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 634500014235 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 634500014236 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 634500014237 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 634500014238 DNA binding residues [nucleotide binding] 634500014239 dimer interface [polypeptide binding]; other site 634500014240 metal binding site [ion binding]; metal-binding site 634500014241 hypothetical protein; Provisional; Region: PRK10203 634500014242 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 634500014243 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 634500014244 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 634500014245 alphaNTD homodimer interface [polypeptide binding]; other site 634500014246 alphaNTD - beta interaction site [polypeptide binding]; other site 634500014247 alphaNTD - beta' interaction site [polypeptide binding]; other site 634500014248 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 634500014249 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 634500014250 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 634500014251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500014252 RNA binding surface [nucleotide binding]; other site 634500014253 30S ribosomal protein S11; Validated; Region: PRK05309 634500014254 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 634500014255 30S ribosomal protein S13; Region: bact_S13; TIGR03631 634500014256 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 634500014257 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 634500014258 SecY translocase; Region: SecY; pfam00344 634500014259 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 634500014260 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 634500014261 23S rRNA binding site [nucleotide binding]; other site 634500014262 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 634500014263 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 634500014264 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 634500014265 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 634500014266 23S rRNA interface [nucleotide binding]; other site 634500014267 5S rRNA interface [nucleotide binding]; other site 634500014268 L27 interface [polypeptide binding]; other site 634500014269 L5 interface [polypeptide binding]; other site 634500014270 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 634500014271 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 634500014272 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 634500014273 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 634500014274 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 634500014275 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 634500014276 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 634500014277 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 634500014278 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 634500014279 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 634500014280 RNA binding site [nucleotide binding]; other site 634500014281 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 634500014282 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 634500014283 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 634500014284 23S rRNA interface [nucleotide binding]; other site 634500014285 putative translocon interaction site; other site 634500014286 signal recognition particle (SRP54) interaction site; other site 634500014287 L23 interface [polypeptide binding]; other site 634500014288 trigger factor interaction site; other site 634500014289 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 634500014290 23S rRNA interface [nucleotide binding]; other site 634500014291 5S rRNA interface [nucleotide binding]; other site 634500014292 putative antibiotic binding site [chemical binding]; other site 634500014293 L25 interface [polypeptide binding]; other site 634500014294 L27 interface [polypeptide binding]; other site 634500014295 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 634500014296 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 634500014297 G-X-X-G motif; other site 634500014298 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 634500014299 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 634500014300 protein-rRNA interface [nucleotide binding]; other site 634500014301 putative translocon binding site; other site 634500014302 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 634500014303 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 634500014304 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 634500014305 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 634500014306 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 634500014307 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 634500014308 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 634500014309 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 634500014310 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 634500014311 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 634500014312 heme binding site [chemical binding]; other site 634500014313 ferroxidase pore; other site 634500014314 ferroxidase diiron center [ion binding]; other site 634500014315 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 634500014316 elongation factor Tu; Reviewed; Region: PRK00049 634500014317 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 634500014318 G1 box; other site 634500014319 GEF interaction site [polypeptide binding]; other site 634500014320 GTP/Mg2+ binding site [chemical binding]; other site 634500014321 Switch I region; other site 634500014322 G2 box; other site 634500014323 G3 box; other site 634500014324 Switch II region; other site 634500014325 G4 box; other site 634500014326 G5 box; other site 634500014327 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 634500014328 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 634500014329 Antibiotic Binding Site [chemical binding]; other site 634500014330 elongation factor G; Reviewed; Region: PRK00007 634500014331 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 634500014332 G1 box; other site 634500014333 putative GEF interaction site [polypeptide binding]; other site 634500014334 GTP/Mg2+ binding site [chemical binding]; other site 634500014335 Switch I region; other site 634500014336 G2 box; other site 634500014337 G3 box; other site 634500014338 Switch II region; other site 634500014339 G4 box; other site 634500014340 G5 box; other site 634500014341 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 634500014342 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 634500014343 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 634500014344 30S ribosomal protein S7; Validated; Region: PRK05302 634500014345 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 634500014346 S17 interaction site [polypeptide binding]; other site 634500014347 S8 interaction site; other site 634500014348 16S rRNA interaction site [nucleotide binding]; other site 634500014349 streptomycin interaction site [chemical binding]; other site 634500014350 23S rRNA interaction site [nucleotide binding]; other site 634500014351 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 634500014352 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 634500014353 sulfur relay protein TusC; Validated; Region: PRK00211 634500014354 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 634500014355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 634500014356 YheO-like PAS domain; Region: PAS_6; pfam08348 634500014357 HTH domain; Region: HTH_22; pfam13309 634500014358 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 634500014359 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 634500014360 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634500014361 phi X174 lysis protein; Provisional; Region: PRK02793 634500014362 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 634500014363 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 634500014364 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 634500014365 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 634500014366 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 634500014367 TrkA-N domain; Region: TrkA_N; pfam02254 634500014368 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 634500014369 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 634500014370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500014371 Walker A/P-loop; other site 634500014372 ATP binding site [chemical binding]; other site 634500014373 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500014374 ABC transporter signature motif; other site 634500014375 Walker B; other site 634500014376 D-loop; other site 634500014377 ABC transporter; Region: ABC_tran_2; pfam12848 634500014378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 634500014379 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 634500014380 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 634500014381 active site 634500014382 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 634500014383 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 634500014384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 634500014385 active site 634500014386 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 634500014387 nudix motif; other site 634500014388 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 634500014389 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 634500014390 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 634500014391 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 634500014392 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 634500014393 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 634500014394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014395 dimer interface [polypeptide binding]; other site 634500014396 conserved gate region; other site 634500014397 putative PBP binding loops; other site 634500014398 ABC-ATPase subunit interface; other site 634500014399 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 634500014400 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 634500014401 Walker A/P-loop; other site 634500014402 ATP binding site [chemical binding]; other site 634500014403 Q-loop/lid; other site 634500014404 ABC transporter signature motif; other site 634500014405 Walker B; other site 634500014406 D-loop; other site 634500014407 H-loop/switch region; other site 634500014408 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 634500014409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500014410 substrate binding pocket [chemical binding]; other site 634500014411 membrane-bound complex binding site; other site 634500014412 hinge residues; other site 634500014413 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 634500014414 putative hydrolase; Provisional; Region: PRK10985 634500014415 hypothetical protein; Provisional; Region: PRK04966 634500014416 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 634500014417 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 634500014418 active site 634500014419 putative substrate binding pocket [chemical binding]; other site 634500014420 Isochorismatase family; Region: Isochorismatase; pfam00857 634500014421 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 634500014422 catalytic triad [active] 634500014423 conserved cis-peptide bond; other site 634500014424 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 634500014425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500014426 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634500014427 TM-ABC transporter signature motif; other site 634500014428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500014429 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 634500014430 TM-ABC transporter signature motif; other site 634500014431 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 634500014432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500014433 Walker A/P-loop; other site 634500014434 ATP binding site [chemical binding]; other site 634500014435 Q-loop/lid; other site 634500014436 ABC transporter signature motif; other site 634500014437 Walker B; other site 634500014438 D-loop; other site 634500014439 H-loop/switch region; other site 634500014440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500014441 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 634500014442 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500014443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500014444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500014445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500014446 dimerization interface [polypeptide binding]; other site 634500014447 Creatinine amidohydrolase; Region: Creatininase; pfam02633 634500014448 phosphoribulokinase; Provisional; Region: PRK15453 634500014449 active site 634500014450 hypothetical protein; Provisional; Region: PRK10738 634500014451 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 634500014452 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 634500014453 ligand binding site [chemical binding]; other site 634500014454 flexible hinge region; other site 634500014455 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 634500014456 putative switch regulator; other site 634500014457 non-specific DNA interactions [nucleotide binding]; other site 634500014458 DNA binding site [nucleotide binding] 634500014459 sequence specific DNA binding site [nucleotide binding]; other site 634500014460 putative cAMP binding site [chemical binding]; other site 634500014461 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 634500014462 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 634500014463 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 634500014464 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 634500014465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500014466 inhibitor-cofactor binding pocket; inhibition site 634500014467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500014468 catalytic residue [active] 634500014469 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 634500014470 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 634500014471 glutamine binding [chemical binding]; other site 634500014472 catalytic triad [active] 634500014473 Fic/DOC family; Region: Fic; cl00960 634500014474 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 634500014475 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 634500014476 substrate binding site [chemical binding]; other site 634500014477 putative transporter; Provisional; Region: PRK03699 634500014478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500014479 putative substrate translocation pore; other site 634500014480 cytosine deaminase; Provisional; Region: PRK09230 634500014481 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 634500014482 active site 634500014483 nitrite reductase subunit NirD; Provisional; Region: PRK14989 634500014484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500014485 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 634500014486 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 634500014487 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 634500014488 siroheme synthase; Provisional; Region: cysG; PRK10637 634500014489 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 634500014490 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 634500014491 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 634500014492 active site 634500014493 SAM binding site [chemical binding]; other site 634500014494 homodimer interface [polypeptide binding]; other site 634500014495 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 634500014496 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 634500014497 active site 634500014498 HIGH motif; other site 634500014499 dimer interface [polypeptide binding]; other site 634500014500 KMSKS motif; other site 634500014501 phosphoglycolate phosphatase; Provisional; Region: PRK13222 634500014502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500014503 motif II; other site 634500014504 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 634500014505 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 634500014506 substrate binding site [chemical binding]; other site 634500014507 hexamer interface [polypeptide binding]; other site 634500014508 metal binding site [ion binding]; metal-binding site 634500014509 DNA adenine methylase; Provisional; Region: PRK10904 634500014510 hypothetical protein; Reviewed; Region: PRK11901 634500014511 cell division protein DamX; Validated; Region: PRK10905 634500014512 cell division protein DamX; Validated; Region: PRK10905 634500014513 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 634500014514 active site 634500014515 dimer interface [polypeptide binding]; other site 634500014516 metal binding site [ion binding]; metal-binding site 634500014517 shikimate kinase; Reviewed; Region: aroK; PRK00131 634500014518 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 634500014519 ADP binding site [chemical binding]; other site 634500014520 magnesium binding site [ion binding]; other site 634500014521 putative shikimate binding site; other site 634500014522 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 634500014523 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 634500014524 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 634500014525 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 634500014526 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 634500014527 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 634500014528 Transglycosylase; Region: Transgly; pfam00912 634500014529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 634500014530 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 634500014531 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 634500014532 dimer interface [polypeptide binding]; other site 634500014533 active site 634500014534 ADP-ribose binding site [chemical binding]; other site 634500014535 nudix motif; other site 634500014536 metal binding site [ion binding]; metal-binding site 634500014537 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 634500014538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 634500014539 RNA binding surface [nucleotide binding]; other site 634500014540 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 634500014541 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 634500014542 dimerization interface [polypeptide binding]; other site 634500014543 domain crossover interface; other site 634500014544 redox-dependent activation switch; other site 634500014545 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 634500014546 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 634500014547 active site 634500014548 substrate-binding site [chemical binding]; other site 634500014549 metal-binding site [ion binding] 634500014550 ATP binding site [chemical binding]; other site 634500014551 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 634500014552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500014553 dimerization interface [polypeptide binding]; other site 634500014554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500014555 dimer interface [polypeptide binding]; other site 634500014556 phosphorylation site [posttranslational modification] 634500014557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500014558 ATP binding site [chemical binding]; other site 634500014559 G-X-G motif; other site 634500014560 osmolarity response regulator; Provisional; Region: ompR; PRK09468 634500014561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 634500014562 active site 634500014563 phosphorylation site [posttranslational modification] 634500014564 intermolecular recognition site; other site 634500014565 dimerization interface [polypeptide binding]; other site 634500014566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 634500014567 DNA binding site [nucleotide binding] 634500014568 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 634500014569 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 634500014570 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 634500014571 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 634500014572 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 634500014573 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 634500014574 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 634500014575 RNA binding site [nucleotide binding]; other site 634500014576 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 634500014577 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 634500014578 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 634500014579 G1 box; other site 634500014580 GTP/Mg2+ binding site [chemical binding]; other site 634500014581 Switch I region; other site 634500014582 G2 box; other site 634500014583 G3 box; other site 634500014584 Switch II region; other site 634500014585 G4 box; other site 634500014586 G5 box; other site 634500014587 Nucleoside recognition; Region: Gate; pfam07670 634500014588 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 634500014589 Nucleoside recognition; Region: Gate; pfam07670 634500014590 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 634500014591 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 634500014592 active site 634500014593 homodimer interface [polypeptide binding]; other site 634500014594 catalytic site [active] 634500014595 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500014596 carboxylesterase BioH; Provisional; Region: PRK10349 634500014597 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 634500014598 DNA utilization protein GntX; Provisional; Region: PRK11595 634500014599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 634500014600 active site 634500014601 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 634500014602 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 634500014603 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 634500014604 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 634500014605 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 634500014606 maltodextrin phosphorylase; Provisional; Region: PRK14985 634500014607 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 634500014608 homodimer interface [polypeptide binding]; other site 634500014609 active site pocket [active] 634500014610 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 634500014611 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 634500014612 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500014613 intramembrane serine protease GlpG; Provisional; Region: PRK10907 634500014614 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 634500014615 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 634500014616 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 634500014617 active site residue [active] 634500014618 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 634500014619 glycogen phosphorylase; Provisional; Region: PRK14986 634500014620 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 634500014621 homodimer interface [polypeptide binding]; other site 634500014622 active site pocket [active] 634500014623 glycogen synthase; Provisional; Region: glgA; PRK00654 634500014624 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 634500014625 ADP-binding pocket [chemical binding]; other site 634500014626 homodimer interface [polypeptide binding]; other site 634500014627 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 634500014628 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 634500014629 ligand binding site; other site 634500014630 oligomer interface; other site 634500014631 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 634500014632 dimer interface [polypeptide binding]; other site 634500014633 N-terminal domain interface [polypeptide binding]; other site 634500014634 sulfate 1 binding site; other site 634500014635 glycogen debranching enzyme; Provisional; Region: PRK03705 634500014636 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 634500014637 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 634500014638 active site 634500014639 catalytic site [active] 634500014640 glycogen branching enzyme; Provisional; Region: PRK05402 634500014641 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 634500014642 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 634500014643 active site 634500014644 catalytic site [active] 634500014645 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 634500014646 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 634500014647 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 634500014648 putative antibiotic transporter; Provisional; Region: PRK10739 634500014649 low affinity gluconate transporter; Provisional; Region: PRK10472 634500014650 gluconate transporter; Region: gntP; TIGR00791 634500014651 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 634500014652 ATP-binding site [chemical binding]; other site 634500014653 Gluconate-6-phosphate binding site [chemical binding]; other site 634500014654 Shikimate kinase; Region: SKI; pfam01202 634500014655 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 634500014656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500014657 DNA binding site [nucleotide binding] 634500014658 domain linker motif; other site 634500014659 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 634500014660 putative ligand binding site [chemical binding]; other site 634500014661 putative dimerization interface [polypeptide binding]; other site 634500014662 Pirin-related protein [General function prediction only]; Region: COG1741 634500014663 Pirin; Region: Pirin; pfam02678 634500014664 putative acetyltransferase YhhY; Provisional; Region: PRK10140 634500014665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 634500014666 Coenzyme A binding pocket [chemical binding]; other site 634500014667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500014668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500014669 DNA binding site [nucleotide binding] 634500014670 domain linker motif; other site 634500014671 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 634500014672 putative ligand binding site [chemical binding]; other site 634500014673 short chain dehydrogenase; Provisional; Region: PRK06198 634500014674 classical (c) SDRs; Region: SDR_c; cd05233 634500014675 NAD(P) binding site [chemical binding]; other site 634500014676 active site 634500014677 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 634500014678 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 634500014679 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 634500014680 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 634500014681 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 634500014682 putative active site [active] 634500014683 catalytic site [active] 634500014684 putative metal binding site [ion binding]; other site 634500014685 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 634500014686 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634500014687 Walker A/P-loop; other site 634500014688 ATP binding site [chemical binding]; other site 634500014689 Q-loop/lid; other site 634500014690 ABC transporter signature motif; other site 634500014691 Walker B; other site 634500014692 D-loop; other site 634500014693 H-loop/switch region; other site 634500014694 TOBE domain; Region: TOBE_2; pfam08402 634500014695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500014696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014697 dimer interface [polypeptide binding]; other site 634500014698 conserved gate region; other site 634500014699 putative PBP binding loops; other site 634500014700 ABC-ATPase subunit interface; other site 634500014701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014702 dimer interface [polypeptide binding]; other site 634500014703 conserved gate region; other site 634500014704 putative PBP binding loops; other site 634500014705 ABC-ATPase subunit interface; other site 634500014706 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 634500014707 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 634500014708 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 634500014709 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 634500014710 Walker A/P-loop; other site 634500014711 ATP binding site [chemical binding]; other site 634500014712 Q-loop/lid; other site 634500014713 ABC transporter signature motif; other site 634500014714 Walker B; other site 634500014715 D-loop; other site 634500014716 H-loop/switch region; other site 634500014717 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 634500014718 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 634500014719 Walker A/P-loop; other site 634500014720 ATP binding site [chemical binding]; other site 634500014721 Q-loop/lid; other site 634500014722 ABC transporter signature motif; other site 634500014723 Walker B; other site 634500014724 D-loop; other site 634500014725 H-loop/switch region; other site 634500014726 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 634500014727 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 634500014728 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 634500014729 TM-ABC transporter signature motif; other site 634500014730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500014731 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 634500014732 TM-ABC transporter signature motif; other site 634500014733 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500014734 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 634500014735 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500014736 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 634500014737 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 634500014738 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 634500014739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 634500014740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 634500014741 DNA binding residues [nucleotide binding] 634500014742 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 634500014743 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 634500014744 cell division protein FtsE; Provisional; Region: PRK10908 634500014745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500014746 Walker A/P-loop; other site 634500014747 ATP binding site [chemical binding]; other site 634500014748 Q-loop/lid; other site 634500014749 ABC transporter signature motif; other site 634500014750 Walker B; other site 634500014751 D-loop; other site 634500014752 H-loop/switch region; other site 634500014753 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 634500014754 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 634500014755 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 634500014756 P loop; other site 634500014757 GTP binding site [chemical binding]; other site 634500014758 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 634500014759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500014760 S-adenosylmethionine binding site [chemical binding]; other site 634500014761 hypothetical protein; Provisional; Region: PRK10910 634500014762 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 634500014763 Predicted membrane protein [Function unknown]; Region: COG3714 634500014764 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 634500014765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 634500014766 metal-binding site [ion binding] 634500014767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500014768 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 634500014769 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 634500014770 CPxP motif; other site 634500014771 hypothetical protein; Provisional; Region: PRK11212 634500014772 hypothetical protein; Provisional; Region: PRK11615 634500014773 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500014774 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 634500014775 Metal-binding active site; metal-binding site 634500014776 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 634500014777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500014778 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500014779 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500014780 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 634500014781 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 634500014782 PYR/PP interface [polypeptide binding]; other site 634500014783 dimer interface [polypeptide binding]; other site 634500014784 TPP binding site [chemical binding]; other site 634500014785 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 634500014786 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 634500014787 TPP-binding site; other site 634500014788 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500014789 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 634500014790 substrate binding site [chemical binding]; other site 634500014791 ATP binding site [chemical binding]; other site 634500014792 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 634500014793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 634500014794 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 634500014795 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 634500014796 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 634500014797 putative active site [active] 634500014798 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 634500014799 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 634500014800 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 634500014801 tetrameric interface [polypeptide binding]; other site 634500014802 NAD binding site [chemical binding]; other site 634500014803 catalytic residues [active] 634500014804 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 634500014805 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 634500014806 Metal-binding active site; metal-binding site 634500014807 major facilitator superfamily transporter; Provisional; Region: PRK05122 634500014808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500014809 putative substrate translocation pore; other site 634500014810 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 634500014811 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 634500014812 Walker A/P-loop; other site 634500014813 ATP binding site [chemical binding]; other site 634500014814 Q-loop/lid; other site 634500014815 ABC transporter signature motif; other site 634500014816 Walker B; other site 634500014817 D-loop; other site 634500014818 H-loop/switch region; other site 634500014819 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 634500014820 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 634500014821 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 634500014822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014823 dimer interface [polypeptide binding]; other site 634500014824 conserved gate region; other site 634500014825 putative PBP binding loops; other site 634500014826 ABC-ATPase subunit interface; other site 634500014827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014828 putative PBP binding loops; other site 634500014829 dimer interface [polypeptide binding]; other site 634500014830 ABC-ATPase subunit interface; other site 634500014831 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 634500014832 Domain of unknown function DUF20; Region: UPF0118; pfam01594 634500014833 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500014834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500014835 DNA-binding site [nucleotide binding]; DNA binding site 634500014836 FCD domain; Region: FCD; pfam07729 634500014837 mannonate dehydratase; Provisional; Region: PRK03906 634500014838 mannonate dehydratase; Region: uxuA; TIGR00695 634500014839 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500014840 DNA binding site [nucleotide binding] 634500014841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 634500014842 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 634500014843 putative ligand binding site [chemical binding]; other site 634500014844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 634500014845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 634500014846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 634500014847 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 634500014848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500014849 putative substrate translocation pore; other site 634500014850 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 634500014851 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 634500014852 HlyD family secretion protein; Region: HlyD_3; pfam13437 634500014853 Predicted transcriptional regulators [Transcription]; Region: COG1733 634500014854 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 634500014855 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 634500014856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500014857 membrane-bound complex binding site; other site 634500014858 aldolase II superfamily protein; Provisional; Region: PRK07044 634500014859 intersubunit interface [polypeptide binding]; other site 634500014860 active site 634500014861 Zn2+ binding site [ion binding]; other site 634500014862 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 634500014863 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 634500014864 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500014865 proline/glycine betaine transporter; Provisional; Region: PRK10642 634500014866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500014867 putative substrate translocation pore; other site 634500014868 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 634500014869 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 634500014870 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 634500014871 putative ligand binding residues [chemical binding]; other site 634500014872 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 634500014873 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500014874 N-terminal plug; other site 634500014875 ligand-binding site [chemical binding]; other site 634500014876 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500014877 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 634500014878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500014879 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 634500014880 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 634500014881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 634500014882 putative aldolase; Validated; Region: PRK08130 634500014883 intersubunit interface [polypeptide binding]; other site 634500014884 active site 634500014885 Zn2+ binding site [ion binding]; other site 634500014886 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 634500014887 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 634500014888 Metal-binding active site; metal-binding site 634500014889 putative transporter; Provisional; Region: PRK09821 634500014890 GntP family permease; Region: GntP_permease; pfam02447 634500014891 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 634500014892 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500014893 DNA-binding site [nucleotide binding]; DNA binding site 634500014894 RNA-binding motif; other site 634500014895 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 634500014896 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 634500014897 active site 634500014898 P-loop; other site 634500014899 phosphorylation site [posttranslational modification] 634500014900 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500014901 active site 634500014902 phosphorylation site [posttranslational modification] 634500014903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500014904 DNA-binding site [nucleotide binding]; DNA binding site 634500014905 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 634500014906 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 634500014907 Predicted flavoproteins [General function prediction only]; Region: COG2081 634500014908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500014909 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 634500014910 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 634500014911 universal stress protein UspB; Provisional; Region: PRK04960 634500014912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 634500014913 Ligand Binding Site [chemical binding]; other site 634500014914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 634500014915 S-adenosylmethionine binding site [chemical binding]; other site 634500014916 oligopeptidase A; Provisional; Region: PRK10911 634500014917 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 634500014918 active site 634500014919 Zn binding site [ion binding]; other site 634500014920 CAAX protease self-immunity; Region: Abi; pfam02517 634500014921 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 634500014922 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 634500014923 glutathione reductase; Validated; Region: PRK06116 634500014924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 634500014925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 634500014926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 634500014927 FIST N domain; Region: FIST; smart00897 634500014928 FIST C domain; Region: FIST_C; pfam10442 634500014929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500014930 dimer interface [polypeptide binding]; other site 634500014931 putative CheW interface [polypeptide binding]; other site 634500014932 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 634500014933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500014934 hypothetical protein; Provisional; Region: PRK05208 634500014935 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 634500014936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 634500014937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500014938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500014939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500014940 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 634500014941 dimerization interface [polypeptide binding]; other site 634500014942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500014943 D-galactonate transporter; Region: 2A0114; TIGR00893 634500014944 putative substrate translocation pore; other site 634500014945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 634500014946 Protein of unknown function, DUF482; Region: DUF482; pfam04339 634500014947 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 634500014948 Actin depolymerization factor/cofilin- and gelsolin-like domains; Region: ADF_gelsolin; cl15697 634500014949 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 634500014950 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 634500014951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500014952 Walker A/P-loop; other site 634500014953 ATP binding site [chemical binding]; other site 634500014954 Q-loop/lid; other site 634500014955 ABC transporter signature motif; other site 634500014956 Walker B; other site 634500014957 D-loop; other site 634500014958 H-loop/switch region; other site 634500014959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500014960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500014961 putative DNA binding site [nucleotide binding]; other site 634500014962 putative Zn2+ binding site [ion binding]; other site 634500014963 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500014964 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 634500014965 dimer interface [polypeptide binding]; other site 634500014966 active site 634500014967 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 634500014968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 634500014969 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 634500014970 nucleotide binding site [chemical binding]; other site 634500014971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 634500014972 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634500014973 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 634500014974 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 634500014975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014976 dimer interface [polypeptide binding]; other site 634500014977 conserved gate region; other site 634500014978 putative PBP binding loops; other site 634500014979 ABC-ATPase subunit interface; other site 634500014980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500014981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500014982 dimer interface [polypeptide binding]; other site 634500014983 ABC-ATPase subunit interface; other site 634500014984 putative PBP binding loops; other site 634500014985 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 634500014986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500014987 Walker A/P-loop; other site 634500014988 ATP binding site [chemical binding]; other site 634500014989 Q-loop/lid; other site 634500014990 ABC transporter signature motif; other site 634500014991 Walker B; other site 634500014992 D-loop; other site 634500014993 H-loop/switch region; other site 634500014994 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 634500014995 putative hydrolase; Provisional; Region: PRK11460 634500014996 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 634500014997 sensor protein KdpD; Provisional; Region: PRK10490 634500014998 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 634500014999 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 634500015000 Ligand Binding Site [chemical binding]; other site 634500015001 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 634500015002 GAF domain; Region: GAF_3; pfam13492 634500015003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 634500015004 dimer interface [polypeptide binding]; other site 634500015005 phosphorylation site [posttranslational modification] 634500015006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500015007 ATP binding site [chemical binding]; other site 634500015008 Mg2+ binding site [ion binding]; other site 634500015009 G-X-G motif; other site 634500015010 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 634500015011 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 634500015012 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500015013 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 634500015014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 634500015015 non-specific DNA binding site [nucleotide binding]; other site 634500015016 salt bridge; other site 634500015017 sequence-specific DNA binding site [nucleotide binding]; other site 634500015018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015019 D-galactonate transporter; Region: 2A0114; TIGR00893 634500015020 putative substrate translocation pore; other site 634500015021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500015022 DNA-binding site [nucleotide binding]; DNA binding site 634500015023 Transcriptional regulators [Transcription]; Region: GntR; COG1802 634500015024 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500015025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 634500015026 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 634500015027 putative NAD(P) binding site [chemical binding]; other site 634500015028 catalytic Zn binding site [ion binding]; other site 634500015029 structural Zn binding site [ion binding]; other site 634500015030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500015031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500015032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 634500015033 dimerization interface [polypeptide binding]; other site 634500015034 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 634500015035 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 634500015036 active site 634500015037 dimer interface [polypeptide binding]; other site 634500015038 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500015039 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 634500015040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500015041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015042 putative PBP binding loops; other site 634500015043 dimer interface [polypeptide binding]; other site 634500015044 ABC-ATPase subunit interface; other site 634500015045 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 634500015046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015047 dimer interface [polypeptide binding]; other site 634500015048 conserved gate region; other site 634500015049 putative PBP binding loops; other site 634500015050 ABC-ATPase subunit interface; other site 634500015051 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500015052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015053 Walker A/P-loop; other site 634500015054 ATP binding site [chemical binding]; other site 634500015055 Q-loop/lid; other site 634500015056 ABC transporter signature motif; other site 634500015057 Walker B; other site 634500015058 D-loop; other site 634500015059 H-loop/switch region; other site 634500015060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500015061 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 634500015062 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015063 Walker A/P-loop; other site 634500015064 ATP binding site [chemical binding]; other site 634500015065 Q-loop/lid; other site 634500015066 ABC transporter signature motif; other site 634500015067 Walker B; other site 634500015068 D-loop; other site 634500015069 H-loop/switch region; other site 634500015070 Beta-lactamase; Region: Beta-lactamase; pfam00144 634500015071 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 634500015072 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 634500015073 SxDxEG motif; other site 634500015074 active site 634500015075 metal binding site [ion binding]; metal-binding site 634500015076 homopentamer interface [polypeptide binding]; other site 634500015077 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 634500015078 homodimer interface [polypeptide binding]; other site 634500015079 homotetramer interface [polypeptide binding]; other site 634500015080 active site pocket [active] 634500015081 cleavage site 634500015082 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 634500015083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634500015084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015085 dimer interface [polypeptide binding]; other site 634500015086 conserved gate region; other site 634500015087 putative PBP binding loops; other site 634500015088 ABC-ATPase subunit interface; other site 634500015089 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 634500015090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015091 dimer interface [polypeptide binding]; other site 634500015092 conserved gate region; other site 634500015093 putative PBP binding loops; other site 634500015094 ABC-ATPase subunit interface; other site 634500015095 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 634500015096 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 634500015097 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 634500015098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015099 Walker A/P-loop; other site 634500015100 ATP binding site [chemical binding]; other site 634500015101 Q-loop/lid; other site 634500015102 ABC transporter signature motif; other site 634500015103 Walker B; other site 634500015104 D-loop; other site 634500015105 H-loop/switch region; other site 634500015106 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500015107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015108 Walker A/P-loop; other site 634500015109 ATP binding site [chemical binding]; other site 634500015110 Q-loop/lid; other site 634500015111 ABC transporter signature motif; other site 634500015112 Walker B; other site 634500015113 D-loop; other site 634500015114 H-loop/switch region; other site 634500015115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 634500015116 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 634500015117 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 634500015118 active site 634500015119 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 634500015120 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 634500015121 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 634500015122 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 634500015123 N-terminal plug; other site 634500015124 ligand-binding site [chemical binding]; other site 634500015125 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 634500015126 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 634500015127 intersubunit interface [polypeptide binding]; other site 634500015128 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 634500015129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 634500015130 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500015131 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 634500015132 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 634500015133 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 634500015134 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 634500015135 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 634500015136 NADP binding site [chemical binding]; other site 634500015137 homodimer interface [polypeptide binding]; other site 634500015138 active site 634500015139 hypothetical protein; Provisional; Region: PRK09273 634500015140 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 634500015141 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 634500015142 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 634500015143 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 634500015144 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 634500015145 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 634500015146 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 634500015147 HSP70 interaction site [polypeptide binding]; other site 634500015148 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 634500015149 substrate binding site [polypeptide binding]; other site 634500015150 dimer interface [polypeptide binding]; other site 634500015151 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 634500015152 Domain of unknown function DUF; Region: DUF204; pfam02659 634500015153 Domain of unknown function DUF; Region: DUF204; pfam02659 634500015154 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 634500015155 magnesium-transporting ATPase; Provisional; Region: PRK15122 634500015156 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 634500015157 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 634500015158 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 634500015159 Soluble P-type ATPase [General function prediction only]; Region: COG4087 634500015160 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 634500015161 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 634500015162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 634500015163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015164 metabolite-proton symporter; Region: 2A0106; TIGR00883 634500015165 putative substrate translocation pore; other site 634500015166 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 634500015167 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 634500015168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500015169 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500015170 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 634500015171 substrate binding site [chemical binding]; other site 634500015172 ATP binding site [chemical binding]; other site 634500015173 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 634500015174 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 634500015175 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 634500015176 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 634500015177 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 634500015178 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 634500015179 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 634500015180 putative diguanylate cyclase; Provisional; Region: PRK13561 634500015181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 634500015182 metal binding site [ion binding]; metal-binding site 634500015183 active site 634500015184 I-site; other site 634500015185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 634500015186 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 634500015187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 634500015188 binding surface 634500015189 TPR motif; other site 634500015190 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 634500015191 cellulose synthase regulator protein; Provisional; Region: PRK11114 634500015192 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 634500015193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 634500015194 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 634500015195 DXD motif; other site 634500015196 PilZ domain; Region: PilZ; pfam07238 634500015197 YhjQ protein; Region: YhjQ; pfam06564 634500015198 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 634500015199 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 634500015200 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 634500015201 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 634500015202 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 634500015203 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 634500015204 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 634500015205 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 634500015206 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 634500015207 cellulose synthase regulator protein; Provisional; Region: PRK11114 634500015208 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 634500015209 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 634500015210 DXD motif; other site 634500015211 PilZ domain; Region: PilZ; pfam07238 634500015212 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 634500015213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 634500015214 P-loop; other site 634500015215 Magnesium ion binding site [ion binding]; other site 634500015216 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 634500015217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015218 Walker A/P-loop; other site 634500015219 ATP binding site [chemical binding]; other site 634500015220 Q-loop/lid; other site 634500015221 ABC transporter signature motif; other site 634500015222 Walker B; other site 634500015223 D-loop; other site 634500015224 H-loop/switch region; other site 634500015225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 634500015226 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 634500015227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015228 Walker A/P-loop; other site 634500015229 ATP binding site [chemical binding]; other site 634500015230 Q-loop/lid; other site 634500015231 ABC transporter signature motif; other site 634500015232 Walker B; other site 634500015233 D-loop; other site 634500015234 H-loop/switch region; other site 634500015235 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634500015236 dipeptide transporter; Provisional; Region: PRK10913 634500015237 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 634500015238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015239 dimer interface [polypeptide binding]; other site 634500015240 conserved gate region; other site 634500015241 putative PBP binding loops; other site 634500015242 ABC-ATPase subunit interface; other site 634500015243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500015244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015245 dimer interface [polypeptide binding]; other site 634500015246 conserved gate region; other site 634500015247 putative PBP binding loops; other site 634500015248 ABC-ATPase subunit interface; other site 634500015249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500015250 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 634500015251 peptide binding site [polypeptide binding]; other site 634500015252 phosphoethanolamine transferase; Provisional; Region: PRK11560 634500015253 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 634500015254 Sulfatase; Region: Sulfatase; pfam00884 634500015255 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 634500015256 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 634500015257 Moco binding site; other site 634500015258 metal coordination site [ion binding]; other site 634500015259 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 634500015260 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 634500015261 Transcriptional regulators [Transcription]; Region: MarR; COG1846 634500015262 MarR family; Region: MarR; pfam01047 634500015263 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 634500015264 HD domain; Region: HD_4; pfam13328 634500015265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 634500015266 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 634500015267 nucleoside/Zn binding site; other site 634500015268 dimer interface [polypeptide binding]; other site 634500015269 catalytic motif [active] 634500015270 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 634500015271 Fic family protein [Function unknown]; Region: COG3177 634500015272 Fic/DOC family; Region: Fic; pfam02661 634500015273 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 634500015274 Uncharacterized conserved protein [Function unknown]; Region: COG4748 634500015275 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 634500015276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 634500015277 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 634500015278 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 634500015279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 634500015280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 634500015281 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500015282 homotrimer interaction site [polypeptide binding]; other site 634500015283 putative active site [active] 634500015284 putative transposase OrfB; Reviewed; Region: PHA02517 634500015285 HTH-like domain; Region: HTH_21; pfam13276 634500015286 Integrase core domain; Region: rve; pfam00665 634500015287 Integrase core domain; Region: rve_3; pfam13683 634500015288 DinB family; Region: DinB; cl17821 634500015289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500015290 DNA binding site [nucleotide binding] 634500015291 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 634500015292 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500015293 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 634500015294 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 634500015295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 634500015296 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 634500015297 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500015298 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 634500015299 Cytochrome c; Region: Cytochrom_C; pfam00034 634500015300 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 634500015301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500015302 dimerization interface [polypeptide binding]; other site 634500015303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500015304 dimer interface [polypeptide binding]; other site 634500015305 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 634500015306 putative CheW interface [polypeptide binding]; other site 634500015307 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 634500015308 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 634500015309 putative dimer interface [polypeptide binding]; other site 634500015310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 634500015311 DNA-binding site [nucleotide binding]; DNA binding site 634500015312 RNA-binding motif; other site 634500015313 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 634500015314 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 634500015315 NADP binding site [chemical binding]; other site 634500015316 dimer interface [polypeptide binding]; other site 634500015317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500015318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500015319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 634500015320 dimerization interface [polypeptide binding]; other site 634500015321 Predicted membrane protein [Function unknown]; Region: COG2323 634500015322 UV-endonuclease UvdE; Region: UvdE; cl10036 634500015323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 634500015324 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 634500015325 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 634500015326 active site 634500015327 metal binding site [ion binding]; metal-binding site 634500015328 interdomain interaction site; other site 634500015329 D5 N terminal like; Region: D5_N; smart00885 634500015330 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 634500015331 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 634500015332 Ash protein family; Region: Phage_ASH; pfam10554 634500015333 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 634500015334 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 634500015335 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 634500015336 integrase; Provisional; Region: PRK09692 634500015337 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 634500015338 active site 634500015339 Int/Topo IB signature motif; other site 634500015340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 634500015341 dimerization interface [polypeptide binding]; other site 634500015342 putative DNA binding site [nucleotide binding]; other site 634500015343 putative Zn2+ binding site [ion binding]; other site 634500015344 ACT domain-containing protein [General function prediction only]; Region: COG4747 634500015345 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 634500015346 Isochorismatase family; Region: Isochorismatase; pfam00857 634500015347 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 634500015348 catalytic triad [active] 634500015349 conserved cis-peptide bond; other site 634500015350 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 634500015351 conserved cys residue [active] 634500015352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500015353 maltose regulon periplasmic protein; Provisional; Region: PRK10564 634500015354 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 634500015355 trimer interface; other site 634500015356 sugar binding site [chemical binding]; other site 634500015357 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 634500015358 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 634500015359 Walker A/P-loop; other site 634500015360 ATP binding site [chemical binding]; other site 634500015361 Q-loop/lid; other site 634500015362 ABC transporter signature motif; other site 634500015363 Walker B; other site 634500015364 D-loop; other site 634500015365 H-loop/switch region; other site 634500015366 TOBE domain; Region: TOBE_2; pfam08402 634500015367 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 634500015368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 634500015369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015370 dimer interface [polypeptide binding]; other site 634500015371 conserved gate region; other site 634500015372 putative PBP binding loops; other site 634500015373 ABC-ATPase subunit interface; other site 634500015374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 634500015375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015376 dimer interface [polypeptide binding]; other site 634500015377 conserved gate region; other site 634500015378 putative PBP binding loops; other site 634500015379 ABC-ATPase subunit interface; other site 634500015380 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 634500015381 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 634500015382 maltodextrin phosphorylase; Provisional; Region: PRK14985 634500015383 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 634500015384 active site pocket [active] 634500015385 transcriptional regulator MalT; Provisional; Region: PRK04841 634500015386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500015387 DNA binding residues [nucleotide binding] 634500015388 dimerization interface [polypeptide binding]; other site 634500015389 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 634500015390 Acyltransferase family; Region: Acyl_transf_3; pfam01757 634500015391 putative fimbrial protein TcfA; Provisional; Region: PRK15308 634500015392 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 634500015393 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 634500015394 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 634500015395 CblD like pilus biogenesis initiator; Region: CblD; cl06460 634500015396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 634500015397 DNA binding residues [nucleotide binding] 634500015398 dimerization interface [polypeptide binding]; other site 634500015399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500015400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500015401 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 634500015402 dimerization interface [polypeptide binding]; other site 634500015403 substrate binding pocket [chemical binding]; other site 634500015404 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 634500015405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015406 putative substrate translocation pore; other site 634500015407 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 634500015408 tartrate dehydrogenase; Region: TTC; TIGR02089 634500015409 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 634500015410 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 634500015411 MOFRL family; Region: MOFRL; pfam05161 634500015412 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 634500015413 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 634500015414 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 634500015415 Protein of unknown function, DUF606; Region: DUF606; pfam04657 634500015416 hypothetical protein; Provisional; Region: PRK08204 634500015417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500015418 active site 634500015419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 634500015420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 634500015421 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 634500015422 putative effector binding pocket; other site 634500015423 putative dimerization interface [polypeptide binding]; other site 634500015424 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 634500015425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015426 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 634500015427 Helix-turn-helix domain; Region: HTH_18; pfam12833 634500015428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 634500015429 Protein of unknown function (DUF796); Region: DUF796; pfam05638 634500015430 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 634500015431 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 634500015432 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 634500015433 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 634500015434 active site pocket [active] 634500015435 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500015436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500015437 DNA-binding site [nucleotide binding]; DNA binding site 634500015438 FCD domain; Region: FCD; pfam07729 634500015439 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 634500015440 allantoinase; Region: allantoinase; TIGR03178 634500015441 active site 634500015442 NMT1/THI5 like; Region: NMT1; pfam09084 634500015443 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 634500015444 active site 634500015445 substrate binding site [chemical binding]; other site 634500015446 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 634500015447 FMN binding site [chemical binding]; other site 634500015448 putative catalytic residues [active] 634500015449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015450 dimer interface [polypeptide binding]; other site 634500015451 conserved gate region; other site 634500015452 putative PBP binding loops; other site 634500015453 ABC-ATPase subunit interface; other site 634500015454 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 634500015455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500015456 Walker A/P-loop; other site 634500015457 ATP binding site [chemical binding]; other site 634500015458 Q-loop/lid; other site 634500015459 ABC transporter signature motif; other site 634500015460 Walker B; other site 634500015461 D-loop; other site 634500015462 H-loop/switch region; other site 634500015463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500015464 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 634500015465 substrate binding pocket [chemical binding]; other site 634500015466 membrane-bound complex binding site; other site 634500015467 hinge residues; other site 634500015468 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 634500015469 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 634500015470 NAD binding site [chemical binding]; other site 634500015471 ligand binding site [chemical binding]; other site 634500015472 catalytic site [active] 634500015473 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 634500015474 homotrimer interaction site [polypeptide binding]; other site 634500015475 putative active site [active] 634500015476 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 634500015477 dimer interface [polypeptide binding]; other site 634500015478 motif 1; other site 634500015479 active site 634500015480 motif 2; other site 634500015481 motif 3; other site 634500015482 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 634500015483 DALR anticodon binding domain; Region: DALR_1; pfam05746 634500015484 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 634500015485 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 634500015486 putative NAD(P) binding site [chemical binding]; other site 634500015487 putative substrate binding site [chemical binding]; other site 634500015488 catalytic Zn binding site [ion binding]; other site 634500015489 structural Zn binding site [ion binding]; other site 634500015490 dimer interface [polypeptide binding]; other site 634500015491 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 634500015492 putative transcriptional regulator; Provisional; Region: PRK10072 634500015493 non-specific DNA binding site [nucleotide binding]; other site 634500015494 salt bridge; other site 634500015495 sequence-specific DNA binding site [nucleotide binding]; other site 634500015496 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500015497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500015498 DNA-binding site [nucleotide binding]; DNA binding site 634500015499 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500015500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 634500015501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015502 Walker A/P-loop; other site 634500015503 ATP binding site [chemical binding]; other site 634500015504 Q-loop/lid; other site 634500015505 ABC transporter signature motif; other site 634500015506 Walker B; other site 634500015507 D-loop; other site 634500015508 H-loop/switch region; other site 634500015509 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634500015510 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 634500015511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 634500015512 Walker A/P-loop; other site 634500015513 ATP binding site [chemical binding]; other site 634500015514 Q-loop/lid; other site 634500015515 ABC transporter signature motif; other site 634500015516 Walker B; other site 634500015517 D-loop; other site 634500015518 H-loop/switch region; other site 634500015519 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 634500015520 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 634500015521 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 634500015522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 634500015523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015524 dimer interface [polypeptide binding]; other site 634500015525 conserved gate region; other site 634500015526 ABC-ATPase subunit interface; other site 634500015527 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 634500015528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015529 dimer interface [polypeptide binding]; other site 634500015530 conserved gate region; other site 634500015531 putative PBP binding loops; other site 634500015532 ABC-ATPase subunit interface; other site 634500015533 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 634500015534 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 634500015535 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 634500015536 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 634500015537 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 634500015538 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 634500015539 active site 634500015540 P-loop; other site 634500015541 phosphorylation site [posttranslational modification] 634500015542 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 634500015543 active site 634500015544 phosphorylation site [posttranslational modification] 634500015545 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 634500015546 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 634500015547 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 634500015548 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 634500015549 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 634500015550 hypothetical protein; Provisional; Region: PRK11020 634500015551 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 634500015552 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 634500015553 putative ligand binding site [chemical binding]; other site 634500015554 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 634500015555 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 634500015556 TM-ABC transporter signature motif; other site 634500015557 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 634500015558 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 634500015559 Walker A/P-loop; other site 634500015560 ATP binding site [chemical binding]; other site 634500015561 Q-loop/lid; other site 634500015562 ABC transporter signature motif; other site 634500015563 Walker B; other site 634500015564 D-loop; other site 634500015565 H-loop/switch region; other site 634500015566 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 634500015567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 634500015568 dimerization interface [polypeptide binding]; other site 634500015569 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 634500015570 dimer interface [polypeptide binding]; other site 634500015571 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 634500015572 putative CheW interface [polypeptide binding]; other site 634500015573 superoxide dismutase; Provisional; Region: PRK10925 634500015574 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 634500015575 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 634500015576 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 634500015577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 634500015578 inhibitor-cofactor binding pocket; inhibition site 634500015579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500015580 catalytic residue [active] 634500015581 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 634500015582 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 634500015583 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 634500015584 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 634500015585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500015586 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 634500015587 molybdopterin cofactor binding site; other site 634500015588 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 634500015589 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 634500015590 molybdopterin cofactor binding site; other site 634500015591 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 634500015592 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 634500015593 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 634500015594 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 634500015595 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 634500015596 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 634500015597 putative glutathione S-transferase; Provisional; Region: PRK10357 634500015598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 634500015599 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 634500015600 dimer interface [polypeptide binding]; other site 634500015601 N-terminal domain interface [polypeptide binding]; other site 634500015602 putative substrate binding pocket (H-site) [chemical binding]; other site 634500015603 selenocysteine synthase; Provisional; Region: PRK04311 634500015604 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 634500015605 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 634500015606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 634500015607 catalytic residue [active] 634500015608 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 634500015609 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 634500015610 G1 box; other site 634500015611 putative GEF interaction site [polypeptide binding]; other site 634500015612 GTP/Mg2+ binding site [chemical binding]; other site 634500015613 Switch I region; other site 634500015614 G2 box; other site 634500015615 G3 box; other site 634500015616 Switch II region; other site 634500015617 G4 box; other site 634500015618 G5 box; other site 634500015619 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 634500015620 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 634500015621 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 634500015622 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 634500015623 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 634500015624 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 634500015625 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 634500015626 active site 634500015627 catalytic triad [active] 634500015628 oxyanion hole [active] 634500015629 Autotransporter beta-domain; Region: Autotransporter; cl17461 634500015630 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 634500015631 putative outer membrane lipoprotein; Provisional; Region: PRK10510 634500015632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 634500015633 ligand binding site [chemical binding]; other site 634500015634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 634500015635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 634500015636 DNA binding site [nucleotide binding] 634500015637 domain linker motif; other site 634500015638 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 634500015639 putative dimerization interface [polypeptide binding]; other site 634500015640 putative ligand binding site [chemical binding]; other site 634500015641 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 634500015642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 634500015643 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 634500015644 substrate binding site [chemical binding]; other site 634500015645 ATP binding site [chemical binding]; other site 634500015646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015647 D-galactonate transporter; Region: 2A0114; TIGR00893 634500015648 putative substrate translocation pore; other site 634500015649 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 634500015650 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 634500015651 dimerization interface [polypeptide binding]; other site 634500015652 ligand binding site [chemical binding]; other site 634500015653 NADP binding site [chemical binding]; other site 634500015654 catalytic site [active] 634500015655 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 634500015656 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 634500015657 NADP binding site [chemical binding]; other site 634500015658 homodimer interface [polypeptide binding]; other site 634500015659 active site 634500015660 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 634500015661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 634500015662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 634500015663 homodimer interface [polypeptide binding]; other site 634500015664 catalytic residue [active] 634500015665 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 634500015666 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 634500015667 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 634500015668 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 634500015669 putative ligand binding site [chemical binding]; other site 634500015670 NAD binding site [chemical binding]; other site 634500015671 catalytic site [active] 634500015672 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 634500015673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015674 putative substrate translocation pore; other site 634500015675 galactonate dehydratase; Provisional; Region: PRK14017 634500015676 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 634500015677 putative active site pocket [active] 634500015678 putative metal binding site [ion binding]; other site 634500015679 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 634500015680 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 634500015681 active site 634500015682 intersubunit interface [polypeptide binding]; other site 634500015683 catalytic residue [active] 634500015684 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 634500015685 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 634500015686 Transcriptional regulators [Transcription]; Region: FadR; COG2186 634500015687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500015688 DNA-binding site [nucleotide binding]; DNA binding site 634500015689 FCD domain; Region: FCD; pfam07729 634500015690 sugar phosphate phosphatase; Provisional; Region: PRK10513 634500015691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500015692 active site 634500015693 motif I; other site 634500015694 motif II; other site 634500015695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 634500015696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 634500015697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 634500015698 DNA binding residues [nucleotide binding] 634500015699 dimerization interface [polypeptide binding]; other site 634500015700 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 634500015701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 634500015702 ATP binding site [chemical binding]; other site 634500015703 Mg2+ binding site [ion binding]; other site 634500015704 G-X-G motif; other site 634500015705 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 634500015706 anchoring element; other site 634500015707 dimer interface [polypeptide binding]; other site 634500015708 ATP binding site [chemical binding]; other site 634500015709 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 634500015710 active site 634500015711 putative metal-binding site [ion binding]; other site 634500015712 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 634500015713 recF protein; Region: recf; TIGR00611 634500015714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500015715 Walker A/P-loop; other site 634500015716 ATP binding site [chemical binding]; other site 634500015717 Q-loop/lid; other site 634500015718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 634500015719 ABC transporter signature motif; other site 634500015720 Walker B; other site 634500015721 D-loop; other site 634500015722 H-loop/switch region; other site 634500015723 DNA polymerase III subunit beta; Validated; Region: PRK05643 634500015724 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 634500015725 putative DNA binding surface [nucleotide binding]; other site 634500015726 dimer interface [polypeptide binding]; other site 634500015727 beta-clamp/clamp loader binding surface; other site 634500015728 beta-clamp/translesion DNA polymerase binding surface; other site 634500015729 DnaA N-terminal domain; Region: DnaA_N; pfam11638 634500015730 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 634500015731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 634500015732 Walker A motif; other site 634500015733 ATP binding site [chemical binding]; other site 634500015734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 634500015735 Walker B motif; other site 634500015736 arginine finger; other site 634500015737 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 634500015738 DnaA box-binding interface [nucleotide binding]; other site 634500015739 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 634500015740 ribonuclease P; Reviewed; Region: rnpA; PRK01732 634500015741 membrane protein insertase; Provisional; Region: PRK01318 634500015742 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 634500015743 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 634500015744 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 634500015745 trmE is a tRNA modification GTPase; Region: trmE; cd04164 634500015746 G1 box; other site 634500015747 GTP/Mg2+ binding site [chemical binding]; other site 634500015748 Switch I region; other site 634500015749 G2 box; other site 634500015750 Switch II region; other site 634500015751 G3 box; other site 634500015752 G4 box; other site 634500015753 G5 box; other site 634500015754 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 634500015755 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 634500015756 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 634500015757 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 634500015758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 634500015759 active site 634500015760 motif I; other site 634500015761 benzoate transport; Region: 2A0115; TIGR00895 634500015762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015763 putative substrate translocation pore; other site 634500015764 transcriptional regulator PhoU; Provisional; Region: PRK11115 634500015765 PhoU domain; Region: PhoU; pfam01895 634500015766 PhoU domain; Region: PhoU; pfam01895 634500015767 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 634500015768 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 634500015769 Walker A/P-loop; other site 634500015770 ATP binding site [chemical binding]; other site 634500015771 Q-loop/lid; other site 634500015772 ABC transporter signature motif; other site 634500015773 Walker B; other site 634500015774 D-loop; other site 634500015775 H-loop/switch region; other site 634500015776 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 634500015777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015778 dimer interface [polypeptide binding]; other site 634500015779 conserved gate region; other site 634500015780 putative PBP binding loops; other site 634500015781 ABC-ATPase subunit interface; other site 634500015782 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 634500015783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 634500015784 dimer interface [polypeptide binding]; other site 634500015785 conserved gate region; other site 634500015786 putative PBP binding loops; other site 634500015787 ABC-ATPase subunit interface; other site 634500015788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 634500015789 substrate binding pocket [chemical binding]; other site 634500015790 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 634500015791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 634500015792 DNA-binding site [nucleotide binding]; DNA binding site 634500015793 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 634500015794 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 634500015795 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 634500015796 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 634500015797 putative active site [active] 634500015798 putative catalytic site [active] 634500015799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015800 D-galactonate transporter; Region: 2A0114; TIGR00893 634500015801 putative substrate translocation pore; other site 634500015802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 634500015803 Glucuronate isomerase; Region: UxaC; pfam02614 634500015804 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 634500015805 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 634500015806 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 634500015807 glutaminase active site [active] 634500015808 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 634500015809 dimer interface [polypeptide binding]; other site 634500015810 active site 634500015811 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 634500015812 dimer interface [polypeptide binding]; other site 634500015813 active site 634500015814 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 634500015815 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 634500015816 Substrate binding site; other site 634500015817 Mg++ binding site; other site 634500015818 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 634500015819 active site 634500015820 substrate binding site [chemical binding]; other site 634500015821 CoA binding site [chemical binding]; other site 634500015822 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 634500015823 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 634500015824 gamma subunit interface [polypeptide binding]; other site 634500015825 epsilon subunit interface [polypeptide binding]; other site 634500015826 LBP interface [polypeptide binding]; other site 634500015827 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 634500015828 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 634500015829 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 634500015830 alpha subunit interaction interface [polypeptide binding]; other site 634500015831 Walker A motif; other site 634500015832 ATP binding site [chemical binding]; other site 634500015833 Walker B motif; other site 634500015834 inhibitor binding site; inhibition site 634500015835 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 634500015836 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 634500015837 core domain interface [polypeptide binding]; other site 634500015838 delta subunit interface [polypeptide binding]; other site 634500015839 epsilon subunit interface [polypeptide binding]; other site 634500015840 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 634500015841 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 634500015842 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 634500015843 beta subunit interaction interface [polypeptide binding]; other site 634500015844 Walker A motif; other site 634500015845 ATP binding site [chemical binding]; other site 634500015846 Walker B motif; other site 634500015847 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 634500015848 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 634500015849 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 634500015850 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 634500015851 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 634500015852 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 634500015853 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 634500015854 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 634500015855 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 634500015856 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 634500015857 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 634500015858 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 634500015859 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 634500015860 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932