-- dump date 20140619_075603 -- class Genbank::misc_feature -- table misc_feature_note -- id note 465817000001 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 465817000002 S-type Pyocin; Region: Pyocin_S; pfam06958 465817000003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 465817000004 active site 465817000005 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 465817000006 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 465817000007 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 465817000008 catalytic residues [active] 465817000009 catalytic nucleophile [active] 465817000010 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 465817000011 multiple promoter invertase; Provisional; Region: mpi; PRK13413 465817000012 catalytic residues [active] 465817000013 catalytic nucleophile [active] 465817000014 Presynaptic Site I dimer interface [polypeptide binding]; other site 465817000015 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 465817000016 Synaptic Flat tetramer interface [polypeptide binding]; other site 465817000017 Synaptic Site I dimer interface [polypeptide binding]; other site 465817000018 DNA binding site [nucleotide binding] 465817000019 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 465817000020 silverDB:46p00009 465817000021 silverDB:46p00010 465817000022 silverDB:46p00011 465817000023 Transcriptional regulator [Transcription]; Region: IclR; COG1414 465817000024 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 465817000025 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 465817000026 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 465817000027 tetramer interface [polypeptide binding]; other site 465817000028 TPP-binding site [chemical binding]; other site 465817000029 heterodimer interface [polypeptide binding]; other site 465817000030 phosphorylation loop region [posttranslational modification] 465817000031 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 465817000032 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 465817000033 alpha subunit interface [polypeptide binding]; other site 465817000034 TPP binding site [chemical binding]; other site 465817000035 heterodimer interface [polypeptide binding]; other site 465817000036 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465817000037 Domain of unknown function (DUF336); Region: DUF336; pfam03928 465817000038 silverDB:46p00016 465817000039 AAA ATPase domain; Region: AAA_15; pfam13175 465817000040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817000041 Walker A/P-loop; other site 465817000042 ATP binding site [chemical binding]; other site 465817000043 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 465817000044 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 465817000045 active site 465817000046 metal binding site [ion binding]; metal-binding site 465817000047 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 465817000048 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 465817000049 catalytic residues [active] 465817000050 catalytic nucleophile [active] 465817000051 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 465817000052 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 465817000053 silverDB:46p00020 465817000054 silverDB:46p00021 465817000055 silverDB:46p00022 465817000056 silverDB:46p00023 465817000057 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 465817000058 silverDB:46p00025 465817000059 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817000060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817000061 metal binding site [ion binding]; metal-binding site 465817000062 active site 465817000063 I-site; other site 465817000064 silverDB:46p00028 465817000065 silverDB:46p00029 465817000066 silverDB:46p00030 465817000067 silverDB:46p00031 465817000068 silverDB:46p00032 465817000069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465817000070 Transposase; Region: HTH_Tnp_1; cl17663 465817000071 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 465817000072 HAMP domain; Region: HAMP; pfam00672 465817000073 dimerization interface [polypeptide binding]; other site 465817000074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817000075 dimer interface [polypeptide binding]; other site 465817000076 putative CheW interface [polypeptide binding]; other site 465817000077 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 465817000078 active site 465817000079 catalytic residues [active] 465817000080 DNA binding site [nucleotide binding] 465817000081 Int/Topo IB signature motif; other site 465817000082 replication protein; Provisional; Region: PRK13742 465817000083 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 465817000084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817000085 P-loop; other site 465817000086 Magnesium ion binding site [ion binding]; other site 465817000087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817000088 Magnesium ion binding site [ion binding]; other site 465817000089 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 465817000090 ParB family; Region: ParB; pfam08775 465817000091 silverDB:46p00039 465817000092 silverDB:46p00040 465817000093 silverDB:46p00043 465817000094 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 465817000095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817000096 non-specific DNA binding site [nucleotide binding]; other site 465817000097 salt bridge; other site 465817000098 sequence-specific DNA binding site [nucleotide binding]; other site 465817000099 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 465817000100 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 465817000101 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 465817000102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 465817000103 DNA binding residues [nucleotide binding] 465817000104 dimerization interface [polypeptide binding]; other site 465817000105 TraY domain; Region: TraY; pfam05509 465817000106 replication protein; Provisional; Region: PRK13702 465817000107 FMN-binding protein MioC; Provisional; Region: PRK09004 465817000108 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 465817000109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465817000110 putative DNA binding site [nucleotide binding]; other site 465817000111 putative Zn2+ binding site [ion binding]; other site 465817000112 AsnC family; Region: AsnC_trans_reg; pfam01037 465817000113 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 465817000114 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 465817000115 Methyltransferase domain; Region: Methyltransf_31; pfam13847 465817000116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817000117 S-adenosylmethionine binding site [chemical binding]; other site 465817000118 hypothetical protein; Provisional; Region: yieM; PRK10997 465817000119 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 465817000120 metal ion-dependent adhesion site (MIDAS); other site 465817000121 regulatory ATPase RavA; Provisional; Region: PRK13531 465817000122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817000123 Walker A motif; other site 465817000124 ATP binding site [chemical binding]; other site 465817000125 Walker B motif; other site 465817000126 arginine finger; other site 465817000127 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 465817000128 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 465817000129 potassium uptake protein; Region: kup; TIGR00794 465817000130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817000131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000132 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 465817000133 putative dimerization interface [polypeptide binding]; other site 465817000134 putative substrate binding pocket [chemical binding]; other site 465817000135 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 465817000136 acetolactate synthase; Reviewed; Region: PRK08617 465817000137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465817000138 PYR/PP interface [polypeptide binding]; other site 465817000139 dimer interface [polypeptide binding]; other site 465817000140 TPP binding site [chemical binding]; other site 465817000141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817000142 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 465817000143 TPP-binding site [chemical binding]; other site 465817000144 D-ribose pyranase; Provisional; Region: PRK11797 465817000145 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 465817000146 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817000147 Walker A/P-loop; other site 465817000148 ATP binding site [chemical binding]; other site 465817000149 Q-loop/lid; other site 465817000150 ABC transporter signature motif; other site 465817000151 Walker B; other site 465817000152 D-loop; other site 465817000153 H-loop/switch region; other site 465817000154 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817000155 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817000156 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817000157 TM-ABC transporter signature motif; other site 465817000158 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 465817000159 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 465817000160 ligand binding site [chemical binding]; other site 465817000161 dimerization interface [polypeptide binding]; other site 465817000162 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 465817000163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817000164 substrate binding site [chemical binding]; other site 465817000165 dimer interface [polypeptide binding]; other site 465817000166 ATP binding site [chemical binding]; other site 465817000167 transcriptional repressor RbsR; Provisional; Region: PRK10423 465817000168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817000169 DNA binding site [nucleotide binding] 465817000170 domain linker motif; other site 465817000171 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 465817000172 dimerization interface [polypeptide binding]; other site 465817000173 ligand binding site [chemical binding]; other site 465817000174 putative transporter; Provisional; Region: PRK10504 465817000175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817000176 putative substrate translocation pore; other site 465817000177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817000178 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 465817000179 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 465817000180 GTP binding site; other site 465817000181 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 465817000182 serine/threonine protein kinase; Provisional; Region: PRK11768 465817000183 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 465817000184 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 465817000185 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 465817000186 catalytic residues [active] 465817000187 hinge region; other site 465817000188 alpha helical domain; other site 465817000189 DNA polymerase I; Provisional; Region: PRK05755 465817000190 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 465817000191 active site 465817000192 metal binding site 1 [ion binding]; metal-binding site 465817000193 putative 5' ssDNA interaction site; other site 465817000194 metal binding site 3; metal-binding site 465817000195 metal binding site 2 [ion binding]; metal-binding site 465817000196 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 465817000197 putative DNA binding site [nucleotide binding]; other site 465817000198 putative metal binding site [ion binding]; other site 465817000199 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 465817000200 active site 465817000201 catalytic site [active] 465817000202 substrate binding site [chemical binding]; other site 465817000203 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 465817000204 active site 465817000205 DNA binding site [nucleotide binding] 465817000206 catalytic site [active] 465817000207 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 465817000208 G1 box; other site 465817000209 GTP/Mg2+ binding site [chemical binding]; other site 465817000210 Switch I region; other site 465817000211 G2 box; other site 465817000212 G3 box; other site 465817000213 Switch II region; other site 465817000214 G4 box; other site 465817000215 G5 box; other site 465817000216 Der GTPase activator; Provisional; Region: PRK05244 465817000217 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 465817000218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817000219 FeS/SAM binding site; other site 465817000220 HemN C-terminal domain; Region: HemN_C; pfam06969 465817000221 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 465817000222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817000223 active site 465817000224 phosphorylation site [posttranslational modification] 465817000225 intermolecular recognition site; other site 465817000226 dimerization interface [polypeptide binding]; other site 465817000227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817000228 Walker A motif; other site 465817000229 ATP binding site [chemical binding]; other site 465817000230 Walker B motif; other site 465817000231 arginine finger; other site 465817000232 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 465817000233 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 465817000234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 465817000235 putative active site [active] 465817000236 heme pocket [chemical binding]; other site 465817000237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817000238 dimer interface [polypeptide binding]; other site 465817000239 phosphorylation site [posttranslational modification] 465817000240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817000241 ATP binding site [chemical binding]; other site 465817000242 Mg2+ binding site [ion binding]; other site 465817000243 G-X-G motif; other site 465817000244 glutamine synthetase; Provisional; Region: glnA; PRK09469 465817000245 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 465817000246 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 465817000247 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 465817000248 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 465817000249 G1 box; other site 465817000250 putative GEF interaction site [polypeptide binding]; other site 465817000251 GTP/Mg2+ binding site [chemical binding]; other site 465817000252 Switch I region; other site 465817000253 G2 box; other site 465817000254 G3 box; other site 465817000255 Switch II region; other site 465817000256 G4 box; other site 465817000257 G5 box; other site 465817000258 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 465817000259 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 465817000260 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 465817000261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817000262 motif II; other site 465817000263 hypothetical protein; Reviewed; Region: PRK01637 465817000264 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 465817000265 putative active site [active] 465817000266 dimerization interface [polypeptide binding]; other site 465817000267 putative tRNAtyr binding site [nucleotide binding]; other site 465817000268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817000269 Coenzyme A binding pocket [chemical binding]; other site 465817000270 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 465817000271 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 465817000272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817000273 RNA binding surface [nucleotide binding]; other site 465817000274 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 465817000275 probable active site [active] 465817000276 AsmA family; Region: AsmA; pfam05170 465817000277 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 465817000278 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 465817000279 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 465817000280 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 465817000281 generic binding surface II; other site 465817000282 ssDNA binding site; other site 465817000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817000284 ATP binding site [chemical binding]; other site 465817000285 putative Mg++ binding site [ion binding]; other site 465817000286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817000287 nucleotide binding region [chemical binding]; other site 465817000288 ATP-binding site [chemical binding]; other site 465817000289 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 465817000290 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465817000291 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 465817000292 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 465817000293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465817000294 Zn2+ binding site [ion binding]; other site 465817000295 Mg2+ binding site [ion binding]; other site 465817000296 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 465817000297 synthetase active site [active] 465817000298 NTP binding site [chemical binding]; other site 465817000299 metal binding site [ion binding]; metal-binding site 465817000300 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 465817000301 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 465817000302 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 465817000303 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 465817000304 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 465817000305 catalytic site [active] 465817000306 G-X2-G-X-G-K; other site 465817000307 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 465817000308 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 465817000309 nucleotide binding pocket [chemical binding]; other site 465817000310 K-X-D-G motif; other site 465817000311 catalytic site [active] 465817000312 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 465817000313 Predicted membrane protein [Function unknown]; Region: COG2860 465817000314 UPF0126 domain; Region: UPF0126; pfam03458 465817000315 UPF0126 domain; Region: UPF0126; pfam03458 465817000316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817000317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817000318 active site 465817000319 phosphorylation site [posttranslational modification] 465817000320 intermolecular recognition site; other site 465817000321 dimerization interface [polypeptide binding]; other site 465817000322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817000323 DNA binding residues [nucleotide binding] 465817000324 dimerization interface [polypeptide binding]; other site 465817000325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817000326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465817000327 putative substrate translocation pore; other site 465817000328 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 465817000329 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 465817000330 PhnA protein; Region: PhnA; pfam03831 465817000331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817000332 Coenzyme A binding pocket [chemical binding]; other site 465817000333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817000334 Helix-turn-helix domain; Region: HTH_18; pfam12833 465817000335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817000336 SnoaL-like domain; Region: SnoaL_2; pfam12680 465817000337 silverDB:etchr00052 465817000338 silverDB:etchr00053 465817000339 silverDB:etchr00054 465817000340 Helix-turn-helix domain; Region: HTH_36; pfam13730 465817000341 silverDB:etchr00057 465817000342 hypothetical protein; Provisional; Region: PRK11820 465817000343 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 465817000344 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 465817000345 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 465817000346 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 465817000347 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 465817000348 Nucleoside recognition; Region: Gate; pfam07670 465817000349 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 465817000350 ribonuclease PH; Reviewed; Region: rph; PRK00173 465817000351 Ribonuclease PH; Region: RNase_PH_bact; cd11362 465817000352 hexamer interface [polypeptide binding]; other site 465817000353 active site 465817000354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817000355 active site 465817000356 division inhibitor protein; Provisional; Region: slmA; PRK09480 465817000357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817000358 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 465817000359 trimer interface [polypeptide binding]; other site 465817000360 active site 465817000361 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 465817000362 Flavoprotein; Region: Flavoprotein; pfam02441 465817000363 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 465817000364 hypothetical protein; Reviewed; Region: PRK00024 465817000365 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 465817000366 MPN+ (JAMM) motif; other site 465817000367 Zinc-binding site [ion binding]; other site 465817000368 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 465817000369 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 465817000370 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 465817000371 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 465817000372 DNA binding site [nucleotide binding] 465817000373 catalytic residue [active] 465817000374 H2TH interface [polypeptide binding]; other site 465817000375 putative catalytic residues [active] 465817000376 turnover-facilitating residue; other site 465817000377 intercalation triad [nucleotide binding]; other site 465817000378 8OG recognition residue [nucleotide binding]; other site 465817000379 putative reading head residues; other site 465817000380 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 465817000381 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 465817000382 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 465817000383 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 465817000384 active site 465817000385 (T/H)XGH motif; other site 465817000386 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 465817000387 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 465817000388 putative metal binding site; other site 465817000389 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 465817000390 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 465817000391 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465817000392 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 465817000393 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817000394 putative active site [active] 465817000395 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 465817000396 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 465817000397 putative ADP-binding pocket [chemical binding]; other site 465817000398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465817000399 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 465817000400 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 465817000401 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817000402 putative active site [active] 465817000403 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 465817000404 putative active site [active] 465817000405 putative catalytic site [active] 465817000406 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 465817000407 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817000408 putative active site [active] 465817000409 putative glycosyl transferase; Provisional; Region: PRK10073 465817000410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 465817000411 active site 465817000412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465817000413 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 465817000414 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 465817000415 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817000416 putative active site [active] 465817000417 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 465817000418 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817000419 putative active site [active] 465817000420 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 465817000421 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 465817000422 NADP binding site [chemical binding]; other site 465817000423 homopentamer interface [polypeptide binding]; other site 465817000424 substrate binding site [chemical binding]; other site 465817000425 active site 465817000426 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 465817000427 NodB motif; other site 465817000428 putative active site [active] 465817000429 putative catalytic site [active] 465817000430 Zn binding site [ion binding]; other site 465817000431 AmiB activator; Provisional; Region: PRK11637 465817000432 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 465817000433 Peptidase family M23; Region: Peptidase_M23; pfam01551 465817000434 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465817000435 active site residue [active] 465817000436 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 465817000437 GSH binding site [chemical binding]; other site 465817000438 catalytic residues [active] 465817000439 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 465817000440 SecA binding site; other site 465817000441 Preprotein binding site; other site 465817000442 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 465817000443 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 465817000444 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 465817000445 serine acetyltransferase; Provisional; Region: cysE; PRK11132 465817000446 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 465817000447 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 465817000448 trimer interface [polypeptide binding]; other site 465817000449 active site 465817000450 substrate binding site [chemical binding]; other site 465817000451 CoA binding site [chemical binding]; other site 465817000452 putative rRNA methylase; Provisional; Region: PRK10358 465817000453 two-component sensor protein; Provisional; Region: cpxA; PRK09470 465817000454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817000455 dimerization interface [polypeptide binding]; other site 465817000456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817000457 dimer interface [polypeptide binding]; other site 465817000458 phosphorylation site [posttranslational modification] 465817000459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817000460 ATP binding site [chemical binding]; other site 465817000461 Mg2+ binding site [ion binding]; other site 465817000462 G-X-G motif; other site 465817000463 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 465817000464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817000465 active site 465817000466 phosphorylation site [posttranslational modification] 465817000467 intermolecular recognition site; other site 465817000468 dimerization interface [polypeptide binding]; other site 465817000469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817000470 DNA binding site [nucleotide binding] 465817000471 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 465817000472 dimer interface [polypeptide binding]; other site 465817000473 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 465817000474 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 465817000475 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 465817000476 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 465817000477 active site 465817000478 ADP/pyrophosphate binding site [chemical binding]; other site 465817000479 dimerization interface [polypeptide binding]; other site 465817000480 allosteric effector site; other site 465817000481 fructose-1,6-bisphosphate binding site; other site 465817000482 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 465817000483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817000484 substrate binding pocket [chemical binding]; other site 465817000485 membrane-bound complex binding site; other site 465817000486 hinge residues; other site 465817000487 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 465817000488 inner membrane protein YhjD; Region: TIGR00766 465817000489 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 465817000490 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 465817000491 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 465817000492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817000493 DNA-binding site [nucleotide binding]; DNA binding site 465817000494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817000495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817000496 homodimer interface [polypeptide binding]; other site 465817000497 catalytic residue [active] 465817000498 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817000499 malate:quinone oxidoreductase; Validated; Region: PRK05257 465817000500 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 465817000501 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 465817000502 triosephosphate isomerase; Provisional; Region: PRK14567 465817000503 substrate binding site [chemical binding]; other site 465817000504 dimer interface [polypeptide binding]; other site 465817000505 catalytic triad [active] 465817000506 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 465817000507 Predicted membrane protein [Function unknown]; Region: COG3152 465817000508 ferredoxin-NADP reductase; Provisional; Region: PRK10926 465817000509 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 465817000510 FAD binding pocket [chemical binding]; other site 465817000511 FAD binding motif [chemical binding]; other site 465817000512 phosphate binding motif [ion binding]; other site 465817000513 beta-alpha-beta structure motif; other site 465817000514 NAD binding pocket [chemical binding]; other site 465817000515 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 465817000516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817000517 putative substrate translocation pore; other site 465817000518 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 465817000519 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 465817000520 putative active site [active] 465817000521 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 465817000522 glycerol kinase; Provisional; Region: glpK; PRK00047 465817000523 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 465817000524 N- and C-terminal domain interface [polypeptide binding]; other site 465817000525 active site 465817000526 MgATP binding site [chemical binding]; other site 465817000527 catalytic site [active] 465817000528 metal binding site [ion binding]; metal-binding site 465817000529 glycerol binding site [chemical binding]; other site 465817000530 homotetramer interface [polypeptide binding]; other site 465817000531 homodimer interface [polypeptide binding]; other site 465817000532 FBP binding site [chemical binding]; other site 465817000533 protein IIAGlc interface [polypeptide binding]; other site 465817000534 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 465817000535 amphipathic channel; other site 465817000536 Asn-Pro-Ala signature motifs; other site 465817000537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 465817000538 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 465817000539 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 465817000540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817000541 Walker A motif; other site 465817000542 ATP binding site [chemical binding]; other site 465817000543 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 465817000544 Walker B motif; other site 465817000545 arginine finger; other site 465817000546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 465817000547 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 465817000548 active site 465817000549 HslU subunit interaction site [polypeptide binding]; other site 465817000550 essential cell division protein FtsN; Provisional; Region: PRK10927 465817000551 cell division protein FtsN; Provisional; Region: PRK12757 465817000552 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817000553 DNA binding site [nucleotide binding] 465817000554 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 465817000555 domain linker motif; other site 465817000556 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 465817000557 dimerization interface [polypeptide binding]; other site 465817000558 ligand binding site [chemical binding]; other site 465817000559 primosome assembly protein PriA; Validated; Region: PRK05580 465817000560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817000561 ATP binding site [chemical binding]; other site 465817000562 putative Mg++ binding site [ion binding]; other site 465817000563 helicase superfamily c-terminal domain; Region: HELICc; smart00490 465817000564 ATP-binding site [chemical binding]; other site 465817000565 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 465817000566 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 465817000567 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 465817000568 active site 465817000569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817000570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000571 LysR substrate binding domain; Region: LysR_substrate; pfam03466 465817000572 dimerization interface [polypeptide binding]; other site 465817000573 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 465817000574 dimerization interface [polypeptide binding]; other site 465817000575 DNA binding site [nucleotide binding] 465817000576 corepressor binding sites; other site 465817000577 cystathionine gamma-synthase; Provisional; Region: PRK08045 465817000578 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465817000579 homodimer interface [polypeptide binding]; other site 465817000580 substrate-cofactor binding pocket; other site 465817000581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817000582 catalytic residue [active] 465817000583 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 465817000584 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 465817000585 putative catalytic residues [active] 465817000586 putative nucleotide binding site [chemical binding]; other site 465817000587 putative aspartate binding site [chemical binding]; other site 465817000588 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 465817000589 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 465817000590 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 465817000591 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 465817000592 FAD binding site [chemical binding]; other site 465817000593 silverDB:etchr00129 465817000594 silverDB:etchr00130 465817000595 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 465817000596 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 465817000597 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 465817000598 acetylornithine deacetylase; Provisional; Region: PRK05111 465817000599 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 465817000600 metal binding site [ion binding]; metal-binding site 465817000601 putative dimer interface [polypeptide binding]; other site 465817000602 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 465817000603 nucleotide binding site [chemical binding]; other site 465817000604 N-acetyl-L-glutamate binding site [chemical binding]; other site 465817000605 argininosuccinate synthase; Provisional; Region: PRK13820 465817000606 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 465817000607 ANP binding site [chemical binding]; other site 465817000608 Substrate Binding Site II [chemical binding]; other site 465817000609 Substrate Binding Site I [chemical binding]; other site 465817000610 argininosuccinate lyase; Provisional; Region: PRK04833 465817000611 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 465817000612 active sites [active] 465817000613 tetramer interface [polypeptide binding]; other site 465817000614 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 465817000615 catalytic triad [active] 465817000616 dimer interface [polypeptide binding]; other site 465817000617 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 465817000618 GSH binding site [chemical binding]; other site 465817000619 catalytic residues [active] 465817000620 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 465817000621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000622 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 465817000623 dimerization interface [polypeptide binding]; other site 465817000624 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 465817000625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817000626 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465817000627 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 465817000628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817000629 hypothetical protein; Provisional; Region: PRK11056 465817000630 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 465817000631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817000632 S-adenosylmethionine binding site [chemical binding]; other site 465817000633 glutamate racemase; Provisional; Region: PRK00865 465817000634 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 465817000635 FAD binding domain; Region: FAD_binding_4; pfam01565 465817000636 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 465817000637 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 465817000638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465817000639 dimerization interface [polypeptide binding]; other site 465817000640 putative Zn2+ binding site [ion binding]; other site 465817000641 putative DNA binding site [nucleotide binding]; other site 465817000642 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 465817000643 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 465817000644 pantothenate kinase; Provisional; Region: PRK05439 465817000645 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 465817000646 ATP-binding site [chemical binding]; other site 465817000647 CoA-binding site [chemical binding]; other site 465817000648 Mg2+-binding site [ion binding]; other site 465817000649 elongation factor Tu; Reviewed; Region: PRK00049 465817000650 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 465817000651 G1 box; other site 465817000652 GEF interaction site [polypeptide binding]; other site 465817000653 GTP/Mg2+ binding site [chemical binding]; other site 465817000654 Switch I region; other site 465817000655 G2 box; other site 465817000656 G3 box; other site 465817000657 Switch II region; other site 465817000658 G4 box; other site 465817000659 G5 box; other site 465817000660 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 465817000661 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 465817000662 Antibiotic Binding Site [chemical binding]; other site 465817000663 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 465817000664 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 465817000665 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 465817000666 putative homodimer interface [polypeptide binding]; other site 465817000667 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 465817000668 heterodimer interface [polypeptide binding]; other site 465817000669 homodimer interface [polypeptide binding]; other site 465817000670 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 465817000671 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 465817000672 23S rRNA interface [nucleotide binding]; other site 465817000673 L7/L12 interface [polypeptide binding]; other site 465817000674 putative thiostrepton binding site; other site 465817000675 L25 interface [polypeptide binding]; other site 465817000676 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 465817000677 mRNA/rRNA interface [nucleotide binding]; other site 465817000678 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 465817000679 23S rRNA interface [nucleotide binding]; other site 465817000680 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 465817000681 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 465817000682 core dimer interface [polypeptide binding]; other site 465817000683 peripheral dimer interface [polypeptide binding]; other site 465817000684 L10 interface [polypeptide binding]; other site 465817000685 L11 interface [polypeptide binding]; other site 465817000686 putative EF-Tu interaction site [polypeptide binding]; other site 465817000687 putative EF-G interaction site [polypeptide binding]; other site 465817000688 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 465817000689 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 465817000690 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 465817000691 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 465817000692 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 465817000693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 465817000694 RPB3 interaction site [polypeptide binding]; other site 465817000695 RPB1 interaction site [polypeptide binding]; other site 465817000696 RPB11 interaction site [polypeptide binding]; other site 465817000697 RPB10 interaction site [polypeptide binding]; other site 465817000698 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 465817000699 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 465817000700 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 465817000701 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 465817000702 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 465817000703 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 465817000704 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 465817000705 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 465817000706 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 465817000707 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 465817000708 DNA binding site [nucleotide binding] 465817000709 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 465817000710 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 465817000711 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 465817000712 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 465817000713 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817000714 silverDB:etchr00158 465817000715 silverDB:etchr00159 465817000716 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 465817000717 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817000718 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 465817000719 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 465817000720 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 465817000721 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 465817000722 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 465817000723 active site 465817000724 homotetramer interface [polypeptide binding]; other site 465817000725 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 465817000726 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 465817000727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817000728 DNA-binding site [nucleotide binding]; DNA binding site 465817000729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817000730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817000731 homodimer interface [polypeptide binding]; other site 465817000732 catalytic residue [active] 465817000733 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 465817000734 thiamine phosphate binding site [chemical binding]; other site 465817000735 active site 465817000736 pyrophosphate binding site [ion binding]; other site 465817000737 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 465817000738 ThiC-associated domain; Region: ThiC-associated; pfam13667 465817000739 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 465817000740 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 465817000741 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 465817000742 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 465817000743 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 465817000744 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 465817000745 putative NADH binding site [chemical binding]; other site 465817000746 putative active site [active] 465817000747 nudix motif; other site 465817000748 putative metal binding site [ion binding]; other site 465817000749 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 465817000750 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 465817000751 substrate binding site [chemical binding]; other site 465817000752 active site 465817000753 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 465817000754 Active_site [active] 465817000755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 465817000756 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 465817000757 IHF dimer interface [polypeptide binding]; other site 465817000758 IHF - DNA interface [nucleotide binding]; other site 465817000759 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 465817000760 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 465817000761 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 465817000762 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 465817000763 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 465817000764 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 465817000765 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 465817000766 purine monophosphate binding site [chemical binding]; other site 465817000767 dimer interface [polypeptide binding]; other site 465817000768 putative catalytic residues [active] 465817000769 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 465817000770 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 465817000771 transcriptional regulator HdfR; Provisional; Region: PRK03601 465817000772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000773 LysR substrate binding domain; Region: LysR_substrate; pfam03466 465817000774 dimerization interface [polypeptide binding]; other site 465817000775 hypothetical protein; Provisional; Region: PRK11027 465817000776 putative ATP-dependent protease; Provisional; Region: PRK09862 465817000777 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 465817000778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817000779 Walker A motif; other site 465817000780 ATP binding site [chemical binding]; other site 465817000781 Walker B motif; other site 465817000782 arginine finger; other site 465817000783 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 465817000784 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 465817000785 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465817000786 PYR/PP interface [polypeptide binding]; other site 465817000787 dimer interface [polypeptide binding]; other site 465817000788 TPP binding site [chemical binding]; other site 465817000789 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817000790 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 465817000791 TPP-binding site [chemical binding]; other site 465817000792 dimer interface [polypeptide binding]; other site 465817000793 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 465817000794 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 465817000795 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 465817000796 homodimer interface [polypeptide binding]; other site 465817000797 substrate-cofactor binding pocket; other site 465817000798 catalytic residue [active] 465817000799 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 465817000800 threonine dehydratase; Reviewed; Region: PRK09224 465817000801 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 465817000802 tetramer interface [polypeptide binding]; other site 465817000803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817000804 catalytic residue [active] 465817000805 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 465817000806 putative Ile/Val binding site [chemical binding]; other site 465817000807 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 465817000808 putative Ile/Val binding site [chemical binding]; other site 465817000809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000810 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 465817000811 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 465817000812 putative dimerization interface [polypeptide binding]; other site 465817000813 ketol-acid reductoisomerase; Validated; Region: PRK05225 465817000814 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 465817000815 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 465817000816 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 465817000817 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 465817000818 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 465817000819 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 465817000820 Part of AAA domain; Region: AAA_19; pfam13245 465817000821 Family description; Region: UvrD_C_2; pfam13538 465817000822 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 465817000823 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 465817000824 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 465817000825 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465817000826 ATP binding site [chemical binding]; other site 465817000827 Mg++ binding site [ion binding]; other site 465817000828 motif III; other site 465817000829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817000830 nucleotide binding region [chemical binding]; other site 465817000831 ATP-binding site [chemical binding]; other site 465817000832 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 465817000833 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 465817000834 catalytic residues [active] 465817000835 transcription termination factor Rho; Provisional; Region: rho; PRK09376 465817000836 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 465817000837 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 465817000838 RNA binding site [nucleotide binding]; other site 465817000839 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 465817000840 multimer interface [polypeptide binding]; other site 465817000841 Walker A motif; other site 465817000842 ATP binding site [chemical binding]; other site 465817000843 Walker B motif; other site 465817000844 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 465817000845 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 465817000846 Mg++ binding site [ion binding]; other site 465817000847 putative catalytic motif [active] 465817000848 substrate binding site [chemical binding]; other site 465817000849 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 465817000850 Chain length determinant protein; Region: Wzz; pfam02706 465817000851 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 465817000852 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 465817000853 active site 465817000854 homodimer interface [polypeptide binding]; other site 465817000855 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 465817000856 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465817000857 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 465817000858 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 465817000859 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 465817000860 NAD binding site [chemical binding]; other site 465817000861 substrate binding site [chemical binding]; other site 465817000862 homodimer interface [polypeptide binding]; other site 465817000863 active site 465817000864 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 465817000865 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 465817000866 substrate binding site; other site 465817000867 tetramer interface; other site 465817000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817000869 Coenzyme A binding pocket [chemical binding]; other site 465817000870 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 465817000871 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 465817000872 inhibitor-cofactor binding pocket; inhibition site 465817000873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817000874 catalytic residue [active] 465817000875 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 465817000876 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 465817000877 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 465817000878 putative common antigen polymerase; Provisional; Region: PRK02975 465817000879 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 465817000880 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 465817000881 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 465817000882 HemY protein N-terminus; Region: HemY_N; pfam07219 465817000883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 465817000884 TPR motif; other site 465817000885 binding surface 465817000886 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 465817000887 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 465817000888 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 465817000889 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 465817000890 active site 465817000891 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 465817000892 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 465817000893 domain interfaces; other site 465817000894 active site 465817000895 adenylate cyclase; Provisional; Region: cyaA; PRK09450 465817000896 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 465817000897 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 465817000898 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 465817000899 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 465817000900 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 465817000901 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 465817000902 hypothetical protein; Provisional; Region: PRK10963 465817000903 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 465817000904 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 465817000905 active site 465817000906 Int/Topo IB signature motif; other site 465817000907 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 465817000908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817000909 motif II; other site 465817000910 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 465817000911 Part of AAA domain; Region: AAA_19; pfam13245 465817000912 Family description; Region: UvrD_C_2; pfam13538 465817000913 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 465817000914 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 465817000915 Cl binding site [ion binding]; other site 465817000916 oligomer interface [polypeptide binding]; other site 465817000917 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 465817000918 CoenzymeA binding site [chemical binding]; other site 465817000919 subunit interaction site [polypeptide binding]; other site 465817000920 PHB binding site; other site 465817000921 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 465817000922 dimerization interface [polypeptide binding]; other site 465817000923 substrate binding site [chemical binding]; other site 465817000924 active site 465817000925 calcium binding site [ion binding]; other site 465817000926 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 465817000927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817000928 ATP binding site [chemical binding]; other site 465817000929 putative Mg++ binding site [ion binding]; other site 465817000930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817000931 nucleotide binding region [chemical binding]; other site 465817000932 ATP-binding site [chemical binding]; other site 465817000933 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 465817000934 Helicase and RNase D C-terminal; Region: HRDC; smart00341 465817000935 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 465817000936 lysophospholipase L2; Provisional; Region: PRK10749 465817000937 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 465817000938 putative hydrolase; Provisional; Region: PRK10976 465817000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817000940 active site 465817000941 motif I; other site 465817000942 motif II; other site 465817000943 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 465817000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817000945 putative substrate translocation pore; other site 465817000946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 465817000947 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 465817000948 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 465817000949 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 465817000950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817000951 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 465817000952 putative dimerization interface [polypeptide binding]; other site 465817000953 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 465817000954 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 465817000955 THF binding site; other site 465817000956 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 465817000957 substrate binding site [chemical binding]; other site 465817000958 THF binding site; other site 465817000959 zinc-binding site [ion binding]; other site 465817000960 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 465817000961 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465817000962 uridine phosphorylase; Provisional; Region: PRK11178 465817000963 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 465817000964 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 465817000965 RmuC family; Region: RmuC; pfam02646 465817000966 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 465817000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817000968 S-adenosylmethionine binding site [chemical binding]; other site 465817000969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 465817000970 SCP-2 sterol transfer family; Region: SCP2; pfam02036 465817000971 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 465817000972 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 465817000973 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 465817000974 sec-independent translocase; Provisional; Region: PRK01770 465817000975 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 465817000976 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 465817000977 active site 465817000978 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 465817000979 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 465817000980 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 465817000981 homodimer interface [polypeptide binding]; other site 465817000982 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 465817000983 FMN reductase; Validated; Region: fre; PRK08051 465817000984 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 465817000985 FAD binding pocket [chemical binding]; other site 465817000986 FAD binding motif [chemical binding]; other site 465817000987 phosphate binding motif [ion binding]; other site 465817000988 beta-alpha-beta structure motif; other site 465817000989 NAD binding pocket [chemical binding]; other site 465817000990 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 465817000991 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465817000992 dimer interface [polypeptide binding]; other site 465817000993 active site 465817000994 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 465817000995 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465817000996 substrate binding site [chemical binding]; other site 465817000997 oxyanion hole (OAH) forming residues; other site 465817000998 trimer interface [polypeptide binding]; other site 465817000999 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465817001000 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465817001001 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465817001002 proline dipeptidase; Provisional; Region: PRK13607 465817001003 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 465817001004 active site 465817001005 hypothetical protein; Provisional; Region: PRK11568 465817001006 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 465817001007 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 465817001008 potassium transporter; Provisional; Region: PRK10750 465817001009 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 465817001010 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 465817001011 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817001012 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817001013 Walker A/P-loop; other site 465817001014 ATP binding site [chemical binding]; other site 465817001015 Q-loop/lid; other site 465817001016 ABC transporter signature motif; other site 465817001017 Walker B; other site 465817001018 D-loop; other site 465817001019 H-loop/switch region; other site 465817001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817001021 dimer interface [polypeptide binding]; other site 465817001022 conserved gate region; other site 465817001023 putative PBP binding loops; other site 465817001024 ABC-ATPase subunit interface; other site 465817001025 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 465817001026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817001027 conserved gate region; other site 465817001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817001029 dimer interface [polypeptide binding]; other site 465817001030 conserved gate region; other site 465817001031 putative PBP binding loops; other site 465817001032 ABC-ATPase subunit interface; other site 465817001033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817001034 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 465817001035 substrate binding pocket [chemical binding]; other site 465817001036 membrane-bound complex binding site; other site 465817001037 hinge residues; other site 465817001038 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 465817001039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 465817001040 putative acyl-acceptor binding pocket; other site 465817001041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817001042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817001043 DNA binding site [nucleotide binding] 465817001044 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001045 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001046 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 465817001047 PapC N-terminal domain; Region: PapC_N; pfam13954 465817001048 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817001049 PapC C-terminal domain; Region: PapC_C; pfam13953 465817001050 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817001051 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817001052 Fimbrial protein; Region: Fimbrial; cl01416 465817001053 Fimbrial protein; Region: Fimbrial; cl01416 465817001054 Fimbrial protein; Region: Fimbrial; pfam00419 465817001055 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817001057 DNA binding residues [nucleotide binding] 465817001058 dimerization interface [polypeptide binding]; other site 465817001059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817001060 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 465817001061 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 465817001062 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817001063 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 465817001064 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 465817001065 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 465817001066 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 465817001067 FMN binding site [chemical binding]; other site 465817001068 active site 465817001069 catalytic residues [active] 465817001070 substrate binding site [chemical binding]; other site 465817001071 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 465817001072 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 465817001073 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 465817001074 Na binding site [ion binding]; other site 465817001075 hypothetical protein; Provisional; Region: PRK10633 465817001076 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 465817001077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465817001078 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 465817001079 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 465817001080 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 465817001081 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465817001082 carboxyltransferase (CT) interaction site; other site 465817001083 biotinylation site [posttranslational modification]; other site 465817001084 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 465817001085 Dehydroquinase class II; Region: DHquinase_II; pfam01220 465817001086 active site 465817001087 trimer interface [polypeptide binding]; other site 465817001088 dimer interface [polypeptide binding]; other site 465817001089 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 465817001090 TMAO/DMSO reductase; Reviewed; Region: PRK05363 465817001091 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 465817001092 Moco binding site; other site 465817001093 metal coordination site [ion binding]; other site 465817001094 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 465817001095 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 465817001096 NADP binding site [chemical binding]; other site 465817001097 dimer interface [polypeptide binding]; other site 465817001098 regulatory protein CsrD; Provisional; Region: PRK11059 465817001099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817001100 metal binding site [ion binding]; metal-binding site 465817001101 active site 465817001102 I-site; other site 465817001103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817001104 rod shape-determining protein MreB; Provisional; Region: PRK13927 465817001105 MreB and similar proteins; Region: MreB_like; cd10225 465817001106 nucleotide binding site [chemical binding]; other site 465817001107 Mg binding site [ion binding]; other site 465817001108 putative protofilament interaction site [polypeptide binding]; other site 465817001109 RodZ interaction site [polypeptide binding]; other site 465817001110 rod shape-determining protein MreC; Region: mreC; TIGR00219 465817001111 rod shape-determining protein MreC; Region: MreC; pfam04085 465817001112 rod shape-determining protein MreD; Provisional; Region: PRK11060 465817001113 Maf-like protein; Region: Maf; pfam02545 465817001114 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 465817001115 active site 465817001116 dimer interface [polypeptide binding]; other site 465817001117 ribonuclease G; Provisional; Region: PRK11712 465817001118 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 465817001119 homodimer interface [polypeptide binding]; other site 465817001120 oligonucleotide binding site [chemical binding]; other site 465817001121 hypothetical protein; Provisional; Region: PRK10899 465817001122 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 465817001123 protease TldD; Provisional; Region: tldD; PRK10735 465817001124 transcriptional regulator; Provisional; Region: PRK10632 465817001125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817001126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817001127 putative effector binding pocket; other site 465817001128 dimerization interface [polypeptide binding]; other site 465817001129 efflux system membrane protein; Provisional; Region: PRK11594 465817001130 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 465817001131 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817001132 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817001133 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 465817001134 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465817001135 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817001136 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817001137 arginine repressor; Provisional; Region: PRK05066 465817001138 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 465817001139 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 465817001140 malate dehydrogenase; Provisional; Region: PRK05086 465817001141 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 465817001142 NAD binding site [chemical binding]; other site 465817001143 dimerization interface [polypeptide binding]; other site 465817001144 Substrate binding site [chemical binding]; other site 465817001145 serine endoprotease; Provisional; Region: PRK10898 465817001146 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 465817001147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465817001148 protein binding site [polypeptide binding]; other site 465817001149 serine endoprotease; Provisional; Region: PRK10139 465817001150 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 465817001151 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465817001152 protein binding site [polypeptide binding]; other site 465817001153 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465817001154 hypothetical protein; Provisional; Region: PRK11677 465817001155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 465817001156 Predicted ATPase [General function prediction only]; Region: COG1485 465817001157 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 465817001158 23S rRNA interface [nucleotide binding]; other site 465817001159 L3 interface [polypeptide binding]; other site 465817001160 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 465817001161 stringent starvation protein A; Provisional; Region: sspA; PRK09481 465817001162 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 465817001163 C-terminal domain interface [polypeptide binding]; other site 465817001164 putative GSH binding site (G-site) [chemical binding]; other site 465817001165 dimer interface [polypeptide binding]; other site 465817001166 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 465817001167 dimer interface [polypeptide binding]; other site 465817001168 N-terminal domain interface [polypeptide binding]; other site 465817001169 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 465817001170 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 465817001171 Flavodoxin; Region: Flavodoxin_1; pfam00258 465817001172 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 465817001173 FAD binding pocket [chemical binding]; other site 465817001174 FAD binding motif [chemical binding]; other site 465817001175 catalytic residues [active] 465817001176 NAD binding pocket [chemical binding]; other site 465817001177 phosphate binding motif [ion binding]; other site 465817001178 beta-alpha-beta structure motif; other site 465817001179 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 465817001180 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 465817001181 active site 465817001182 dimer interface [polypeptide binding]; other site 465817001183 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 465817001184 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 465817001185 active site 465817001186 FMN binding site [chemical binding]; other site 465817001187 substrate binding site [chemical binding]; other site 465817001188 3Fe-4S cluster binding site [ion binding]; other site 465817001189 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 465817001190 domain_subunit interface; other site 465817001191 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 465817001192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817001193 putative active site [active] 465817001194 heme pocket [chemical binding]; other site 465817001195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817001196 dimer interface [polypeptide binding]; other site 465817001197 phosphorylation site [posttranslational modification] 465817001198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817001199 ATP binding site [chemical binding]; other site 465817001200 Mg2+ binding site [ion binding]; other site 465817001201 G-X-G motif; other site 465817001202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817001203 active site 465817001204 phosphorylation site [posttranslational modification] 465817001205 intermolecular recognition site; other site 465817001206 dimerization interface [polypeptide binding]; other site 465817001207 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 465817001208 putative binding surface; other site 465817001209 active site 465817001210 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 465817001211 Transglycosylase; Region: Transgly; cl17702 465817001212 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 465817001213 dimerization domain swap beta strand [polypeptide binding]; other site 465817001214 regulatory protein interface [polypeptide binding]; other site 465817001215 active site 465817001216 regulatory phosphorylation site [posttranslational modification]; other site 465817001217 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 465817001218 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 465817001219 active site 465817001220 phosphorylation site [posttranslational modification] 465817001221 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 465817001222 30S subunit binding site; other site 465817001223 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 465817001224 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 465817001225 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 465817001226 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 465817001227 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 465817001228 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 465817001229 Walker A/P-loop; other site 465817001230 ATP binding site [chemical binding]; other site 465817001231 Q-loop/lid; other site 465817001232 ABC transporter signature motif; other site 465817001233 Walker B; other site 465817001234 D-loop; other site 465817001235 H-loop/switch region; other site 465817001236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 465817001237 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 465817001238 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 465817001239 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 465817001240 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 465817001241 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 465817001242 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 465817001243 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 465817001244 putative active site [active] 465817001245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 465817001246 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 465817001247 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 465817001248 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 465817001249 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 465817001250 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 465817001251 Walker A/P-loop; other site 465817001252 ATP binding site [chemical binding]; other site 465817001253 Q-loop/lid; other site 465817001254 ABC transporter signature motif; other site 465817001255 Walker B; other site 465817001256 D-loop; other site 465817001257 H-loop/switch region; other site 465817001258 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 465817001259 conserved hypothetical integral membrane protein; Region: TIGR00056 465817001260 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 465817001261 mce related protein; Region: MCE; pfam02470 465817001262 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 465817001263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 465817001264 anti sigma factor interaction site; other site 465817001265 regulatory phosphorylation site [posttranslational modification]; other site 465817001266 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 465817001267 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 465817001268 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 465817001269 hinge; other site 465817001270 active site 465817001271 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 465817001272 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 465817001273 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 465817001274 substrate binding pocket [chemical binding]; other site 465817001275 chain length determination region; other site 465817001276 substrate-Mg2+ binding site; other site 465817001277 catalytic residues [active] 465817001278 aspartate-rich region 1; other site 465817001279 active site lid residues [active] 465817001280 aspartate-rich region 2; other site 465817001281 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 465817001282 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 465817001283 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 465817001284 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 465817001285 EamA-like transporter family; Region: EamA; pfam00892 465817001286 GTPase CgtA; Reviewed; Region: obgE; PRK12298 465817001287 GTP1/OBG; Region: GTP1_OBG; pfam01018 465817001288 Obg GTPase; Region: Obg; cd01898 465817001289 G1 box; other site 465817001290 GTP/Mg2+ binding site [chemical binding]; other site 465817001291 Switch I region; other site 465817001292 G2 box; other site 465817001293 G3 box; other site 465817001294 Switch II region; other site 465817001295 G4 box; other site 465817001296 G5 box; other site 465817001297 sensor protein BasS/PmrB; Provisional; Region: PRK10755 465817001298 HAMP domain; Region: HAMP; pfam00672 465817001299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 465817001300 dimer interface [polypeptide binding]; other site 465817001301 phosphorylation site [posttranslational modification] 465817001302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817001303 ATP binding site [chemical binding]; other site 465817001304 Mg2+ binding site [ion binding]; other site 465817001305 G-X-G motif; other site 465817001306 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 465817001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817001308 active site 465817001309 phosphorylation site [posttranslational modification] 465817001310 intermolecular recognition site; other site 465817001311 dimerization interface [polypeptide binding]; other site 465817001312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817001313 DNA binding site [nucleotide binding] 465817001314 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 465817001315 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 465817001316 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 465817001317 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 465817001318 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 465817001319 RNA-binding protein YhbY; Provisional; Region: PRK10343 465817001320 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 465817001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817001322 S-adenosylmethionine binding site [chemical binding]; other site 465817001323 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 465817001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817001325 Walker A motif; other site 465817001326 ATP binding site [chemical binding]; other site 465817001327 Walker B motif; other site 465817001328 arginine finger; other site 465817001329 Peptidase family M41; Region: Peptidase_M41; pfam01434 465817001330 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 465817001331 dihydropteroate synthase; Region: DHPS; TIGR01496 465817001332 substrate binding pocket [chemical binding]; other site 465817001333 dimer interface [polypeptide binding]; other site 465817001334 inhibitor binding site; inhibition site 465817001335 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 465817001336 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 465817001337 active site 465817001338 substrate binding site [chemical binding]; other site 465817001339 metal binding site [ion binding]; metal-binding site 465817001340 Preprotein translocase SecG subunit; Region: SecG; pfam03840 465817001341 ribosome maturation protein RimP; Reviewed; Region: PRK00092 465817001342 Sm and related proteins; Region: Sm_like; cl00259 465817001343 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 465817001344 putative oligomer interface [polypeptide binding]; other site 465817001345 putative RNA binding site [nucleotide binding]; other site 465817001346 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 465817001347 NusA N-terminal domain; Region: NusA_N; pfam08529 465817001348 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 465817001349 RNA binding site [nucleotide binding]; other site 465817001350 homodimer interface [polypeptide binding]; other site 465817001351 NusA-like KH domain; Region: KH_5; pfam13184 465817001352 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 465817001353 G-X-X-G motif; other site 465817001354 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 465817001355 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 465817001356 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 465817001357 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 465817001358 translation initiation factor IF-2; Region: IF-2; TIGR00487 465817001359 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 465817001360 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 465817001361 G1 box; other site 465817001362 putative GEF interaction site [polypeptide binding]; other site 465817001363 GTP/Mg2+ binding site [chemical binding]; other site 465817001364 Switch I region; other site 465817001365 G2 box; other site 465817001366 G3 box; other site 465817001367 Switch II region; other site 465817001368 G4 box; other site 465817001369 G5 box; other site 465817001370 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 465817001371 Translation-initiation factor 2; Region: IF-2; pfam11987 465817001372 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 465817001373 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 465817001374 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 465817001375 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 465817001376 RNA binding site [nucleotide binding]; other site 465817001377 active site 465817001378 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 465817001379 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 465817001380 16S/18S rRNA binding site [nucleotide binding]; other site 465817001381 S13e-L30e interaction site [polypeptide binding]; other site 465817001382 25S rRNA binding site [nucleotide binding]; other site 465817001383 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 465817001384 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 465817001385 RNase E interface [polypeptide binding]; other site 465817001386 trimer interface [polypeptide binding]; other site 465817001387 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 465817001388 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 465817001389 RNase E interface [polypeptide binding]; other site 465817001390 trimer interface [polypeptide binding]; other site 465817001391 active site 465817001392 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 465817001393 RNA binding site [nucleotide binding]; other site 465817001394 domain interface; other site 465817001395 lipoprotein NlpI; Provisional; Region: PRK11189 465817001396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 465817001397 binding surface 465817001398 TPR motif; other site 465817001399 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 465817001400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465817001401 ATP binding site [chemical binding]; other site 465817001402 Mg++ binding site [ion binding]; other site 465817001403 motif III; other site 465817001404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817001405 nucleotide binding region [chemical binding]; other site 465817001406 ATP-binding site [chemical binding]; other site 465817001407 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 465817001408 putative RNA binding site [nucleotide binding]; other site 465817001409 hypothetical protein; Provisional; Region: PRK10508 465817001410 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 465817001411 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 465817001412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817001413 Coenzyme A binding pocket [chemical binding]; other site 465817001414 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 465817001415 GIY-YIG motif/motif A; other site 465817001416 putative active site [active] 465817001417 putative metal binding site [ion binding]; other site 465817001418 Predicted membrane protein [Function unknown]; Region: COG3766 465817001419 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 465817001420 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 465817001421 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 465817001422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817001423 FeS/SAM binding site; other site 465817001424 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 465817001425 ATP cone domain; Region: ATP-cone; pfam03477 465817001426 Class III ribonucleotide reductase; Region: RNR_III; cd01675 465817001427 effector binding site; other site 465817001428 active site 465817001429 Zn binding site [ion binding]; other site 465817001430 glycine loop; other site 465817001431 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 465817001432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817001433 ATP binding site [chemical binding]; other site 465817001434 putative Mg++ binding site [ion binding]; other site 465817001435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817001436 nucleotide binding region [chemical binding]; other site 465817001437 ATP-binding site [chemical binding]; other site 465817001438 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 465817001439 homotrimer interaction site [polypeptide binding]; other site 465817001440 putative active site [active] 465817001441 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 465817001442 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 465817001443 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 465817001444 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 465817001445 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 465817001446 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 465817001447 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 465817001448 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 465817001449 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 465817001450 RNase E inhibitor protein; Provisional; Region: PRK11191 465817001451 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465817001452 Coenzyme A binding pocket [chemical binding]; other site 465817001453 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 465817001454 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 465817001455 HIGH motif; other site 465817001456 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 465817001457 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 465817001458 active site 465817001459 KMSKS motif; other site 465817001460 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 465817001461 tRNA binding surface [nucleotide binding]; other site 465817001462 anticodon binding site; other site 465817001463 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 465817001464 DNA polymerase III subunit chi; Validated; Region: PRK05728 465817001465 multifunctional aminopeptidase A; Provisional; Region: PRK00913 465817001466 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 465817001467 interface (dimer of trimers) [polypeptide binding]; other site 465817001468 Substrate-binding/catalytic site; other site 465817001469 Zn-binding sites [ion binding]; other site 465817001470 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 465817001471 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 465817001472 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 465817001473 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 465817001474 Predicted transcriptional regulator [Transcription]; Region: COG3905 465817001475 Predicted membrane protein [Function unknown]; Region: COG2733 465817001476 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 465817001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 465817001478 Walker A motif; other site 465817001479 ATP binding site [chemical binding]; other site 465817001480 hypothetical protein; Provisional; Region: PRK11667 465817001481 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 465817001482 active site 465817001483 Int/Topo IB signature motif; other site 465817001484 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 465817001485 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 465817001486 HsdM N-terminal domain; Region: HsdM_N; pfam12161 465817001487 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 465817001488 Methyltransferase domain; Region: Methyltransf_26; pfam13659 465817001489 S-adenosylmethionine binding site [chemical binding]; other site 465817001490 Protein of unknown function DUF45; Region: DUF45; cl00636 465817001491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 465817001492 Integrase core domain; Region: rve_3; pfam13683 465817001493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817001494 dimerization interface [polypeptide binding]; other site 465817001495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817001496 DNA binding residues [nucleotide binding] 465817001497 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817001498 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817001499 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817001500 Fimbrial protein; Region: Fimbrial; cl01416 465817001501 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 465817001502 PapC N-terminal domain; Region: PapC_N; pfam13954 465817001503 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817001504 PapC C-terminal domain; Region: PapC_C; pfam13953 465817001505 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817001506 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817001507 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817001509 DNA binding site [nucleotide binding] 465817001510 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817001511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817001512 metal binding site [ion binding]; metal-binding site 465817001513 active site 465817001514 I-site; other site 465817001515 Transposase; Region: HTH_Tnp_1; pfam01527 465817001516 silverDB:etchr00392 465817001517 silverDB:etchr00394 465817001518 silverDB:etchr00395 465817001519 Restriction endonuclease [Defense mechanisms]; Region: COG3587 465817001520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817001521 ATP binding site [chemical binding]; other site 465817001522 putative Mg++ binding site [ion binding]; other site 465817001523 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 465817001524 DNA methylase; Region: N6_N4_Mtase; pfam01555 465817001525 DNA methylase; Region: N6_N4_Mtase; pfam01555 465817001526 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cl07688 465817001527 mannosyl binding site [chemical binding]; other site 465817001528 Fimbrial protein; Region: Fimbrial; pfam00419 465817001529 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001530 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817001531 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817001532 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817001533 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 465817001534 PapC N-terminal domain; Region: PapC_N; pfam13954 465817001535 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817001536 PapC C-terminal domain; Region: PapC_C; pfam13953 465817001537 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001538 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817001539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817001540 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 465817001541 DNA binding residues [nucleotide binding] 465817001542 hypothetical protein; Provisional; Region: PRK10396 465817001543 yecA family protein; Region: ygfB_yecA; TIGR02292 465817001544 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 465817001545 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 465817001546 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465817001547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817001548 non-specific DNA binding site [nucleotide binding]; other site 465817001549 salt bridge; other site 465817001550 sequence-specific DNA binding site [nucleotide binding]; other site 465817001551 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 465817001552 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 465817001553 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 465817001554 phosphoglycerol transferase I; Provisional; Region: PRK03776 465817001555 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 465817001556 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 465817001557 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 465817001558 active site 465817001559 SUMO-1 interface [polypeptide binding]; other site 465817001560 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 465817001561 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 465817001562 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 465817001563 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 465817001564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817001565 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 465817001566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817001567 DNA binding residues [nucleotide binding] 465817001568 DNA primase; Validated; Region: dnaG; PRK05667 465817001569 CHC2 zinc finger; Region: zf-CHC2; pfam01807 465817001570 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 465817001571 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 465817001572 active site 465817001573 metal binding site [ion binding]; metal-binding site 465817001574 interdomain interaction site; other site 465817001575 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 465817001576 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 465817001577 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 465817001578 UGMP family protein; Validated; Region: PRK09604 465817001579 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 465817001580 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 465817001581 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 465817001582 homooctamer interface [polypeptide binding]; other site 465817001583 active site 465817001584 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 465817001585 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 465817001586 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 465817001587 active site 465817001588 NTP binding site [chemical binding]; other site 465817001589 metal binding triad [ion binding]; metal-binding site 465817001590 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 465817001591 HD domain; Region: HD; pfam01966 465817001592 SH3 domain-containing protein; Provisional; Region: PRK10884 465817001593 Bacterial SH3 domain homologues; Region: SH3b; smart00287 465817001594 Uncharacterized conserved protein [Function unknown]; Region: COG3025 465817001595 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 465817001596 putative active site [active] 465817001597 putative metal binding residues [ion binding]; other site 465817001598 signature motif; other site 465817001599 putative triphosphate binding site [ion binding]; other site 465817001600 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 465817001601 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 465817001602 metal binding triad; other site 465817001603 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 465817001604 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 465817001605 metal binding triad; other site 465817001606 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 465817001607 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 465817001608 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 465817001609 putative ribose interaction site [chemical binding]; other site 465817001610 putative ADP binding site [chemical binding]; other site 465817001611 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 465817001612 active site 465817001613 HIGH motif; other site 465817001614 nucleotide binding site [chemical binding]; other site 465817001615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 465817001616 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 465817001617 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 465817001618 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 465817001619 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 465817001620 putative active site [active] 465817001621 metal binding site [ion binding]; metal-binding site 465817001622 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 465817001623 hypothetical protein; Provisional; Region: PRK11653 465817001624 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 465817001625 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 465817001626 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 465817001627 dimer interface [polypeptide binding]; other site 465817001628 ADP-ribose binding site [chemical binding]; other site 465817001629 active site 465817001630 nudix motif; other site 465817001631 metal binding site [ion binding]; metal-binding site 465817001632 putative dehydrogenase; Provisional; Region: PRK11039 465817001633 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 465817001634 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 465817001635 active site 465817001636 metal binding site [ion binding]; metal-binding site 465817001637 hexamer interface [polypeptide binding]; other site 465817001638 esterase YqiA; Provisional; Region: PRK11071 465817001639 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 465817001640 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 465817001641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817001642 ATP binding site [chemical binding]; other site 465817001643 Mg2+ binding site [ion binding]; other site 465817001644 G-X-G motif; other site 465817001645 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 465817001646 anchoring element; other site 465817001647 dimer interface [polypeptide binding]; other site 465817001648 ATP binding site [chemical binding]; other site 465817001649 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 465817001650 active site 465817001651 metal binding site [ion binding]; metal-binding site 465817001652 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 465817001653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817001654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817001655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817001656 dimerization interface [polypeptide binding]; other site 465817001657 Uncharacterized conserved protein [Function unknown]; Region: COG1359 465817001658 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 465817001659 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 465817001660 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 465817001661 CAP-like domain; other site 465817001662 active site 465817001663 primary dimer interface [polypeptide binding]; other site 465817001664 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 465817001665 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 465817001666 putative acyl-acceptor binding pocket; other site 465817001667 FtsI repressor; Provisional; Region: PRK10883 465817001668 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 465817001669 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 465817001670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817001671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817001672 active site 465817001673 catalytic tetrad [active] 465817001674 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 465817001675 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 465817001676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817001677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817001678 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 465817001679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817001680 inhibitor-cofactor binding pocket; inhibition site 465817001681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817001682 catalytic residue [active] 465817001683 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 465817001684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817001685 catalytic residue [active] 465817001686 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 465817001687 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465817001688 cystathionine beta-lyase; Provisional; Region: PRK08114 465817001689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465817001690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817001691 catalytic residue [active] 465817001692 biopolymer transport protein ExbB; Provisional; Region: PRK10414 465817001693 biopolymer transport protein ExbD; Provisional; Region: PRK11267 465817001694 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 465817001695 citrate-proton symporter; Provisional; Region: PRK15075 465817001696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817001697 putative substrate translocation pore; other site 465817001698 oxidoreductase; Provisional; Region: PRK07985 465817001699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817001700 NAD(P) binding site [chemical binding]; other site 465817001701 active site 465817001702 Spore Coat Protein U domain; Region: SCPU; pfam05229 465817001703 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 465817001704 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817001705 PapC C-terminal domain; Region: PapC_C; pfam13953 465817001706 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817001707 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817001708 Spore Coat Protein U domain; Region: SCPU; pfam05229 465817001709 Spore Coat Protein U domain; Region: SCPU; pfam05229 465817001710 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 465817001711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817001712 DNA-binding site [nucleotide binding]; DNA binding site 465817001713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817001714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817001715 homodimer interface [polypeptide binding]; other site 465817001716 catalytic residue [active] 465817001717 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 465817001718 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 465817001719 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 465817001720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817001721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817001722 DNA binding site [nucleotide binding] 465817001723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 465817001724 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 465817001725 putative acyl-acceptor binding pocket; other site 465817001726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 465817001727 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 465817001728 active site 465817001729 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 465817001730 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 465817001731 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 465817001732 putative ligand binding residues [chemical binding]; other site 465817001733 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 465817001734 Ferritin-like domain; Region: Ferritin; pfam00210 465817001735 ferroxidase diiron center [ion binding]; other site 465817001736 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 465817001737 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817001738 N-terminal plug; other site 465817001739 ligand-binding site [chemical binding]; other site 465817001740 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 465817001741 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465817001742 Walker A/P-loop; other site 465817001743 ATP binding site [chemical binding]; other site 465817001744 Q-loop/lid; other site 465817001745 ABC transporter signature motif; other site 465817001746 Walker B; other site 465817001747 D-loop; other site 465817001748 H-loop/switch region; other site 465817001749 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817001750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817001751 dimer interface [polypeptide binding]; other site 465817001752 putative PBP binding regions; other site 465817001753 ABC-ATPase subunit interface; other site 465817001754 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817001755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817001756 ABC-ATPase subunit interface; other site 465817001757 dimer interface [polypeptide binding]; other site 465817001758 putative PBP binding regions; other site 465817001759 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 465817001760 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 465817001761 siderophore binding site; other site 465817001762 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 465817001763 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 465817001764 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 465817001765 silverDB:etchr00474 465817001766 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465817001767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817001768 substrate binding pocket [chemical binding]; other site 465817001769 membrane-bound complex binding site; other site 465817001770 hinge residues; other site 465817001771 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817001772 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817001773 Walker A/P-loop; other site 465817001774 ATP binding site [chemical binding]; other site 465817001775 Q-loop/lid; other site 465817001776 ABC transporter signature motif; other site 465817001777 Walker B; other site 465817001778 D-loop; other site 465817001779 H-loop/switch region; other site 465817001780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817001781 dimer interface [polypeptide binding]; other site 465817001782 conserved gate region; other site 465817001783 putative PBP binding loops; other site 465817001784 ABC-ATPase subunit interface; other site 465817001785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817001786 dimer interface [polypeptide binding]; other site 465817001787 conserved gate region; other site 465817001788 putative PBP binding loops; other site 465817001789 ABC-ATPase subunit interface; other site 465817001790 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 465817001791 beta-galactosidase; Region: BGL; TIGR03356 465817001792 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 465817001793 methionine cluster; other site 465817001794 active site 465817001795 phosphorylation site [posttranslational modification] 465817001796 metal binding site [ion binding]; metal-binding site 465817001797 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 465817001798 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 465817001799 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 465817001800 active site 465817001801 P-loop; other site 465817001802 phosphorylation site [posttranslational modification] 465817001803 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817001804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817001805 DNA binding site [nucleotide binding] 465817001806 domain linker motif; other site 465817001807 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 465817001808 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 465817001809 Na binding site [ion binding]; other site 465817001810 silverDB:etchr00490 465817001811 aromatic amino acid exporter; Provisional; Region: PRK11689 465817001812 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 465817001813 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 465817001814 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 465817001815 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 465817001816 GAF domain; Region: GAF; pfam01590 465817001817 Histidine kinase; Region: His_kinase; pfam06580 465817001818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817001819 ATP binding site [chemical binding]; other site 465817001820 Mg2+ binding site [ion binding]; other site 465817001821 G-X-G motif; other site 465817001822 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 465817001823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817001824 active site 465817001825 phosphorylation site [posttranslational modification] 465817001826 intermolecular recognition site; other site 465817001827 dimerization interface [polypeptide binding]; other site 465817001828 LytTr DNA-binding domain; Region: LytTR; smart00850 465817001829 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 465817001830 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 465817001831 P-loop, Walker A motif; other site 465817001832 Base recognition motif; other site 465817001833 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 465817001834 Uncharacterized small protein [Function unknown]; Region: COG2879 465817001835 carbon starvation protein A; Provisional; Region: PRK15015 465817001836 Carbon starvation protein CstA; Region: CstA; pfam02554 465817001837 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 465817001838 silverDB:etchr00503 465817001839 Centromere-associated protein K; Region: CENP-K; pfam11802 465817001840 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 465817001841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817001842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817001843 dimerization interface [polypeptide binding]; other site 465817001844 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 465817001845 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 465817001846 C-lysozyme inhibitor; Provisional; Region: PRK09993 465817001847 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465817001848 active site 465817001849 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 465817001850 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 465817001851 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 465817001852 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 465817001853 type III secretion apparatus protein, YscR/HrcR family; Region: yscR; TIGR01102 465817001854 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 465817001855 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 465817001856 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 465817001857 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 465817001858 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817001859 Walker A motif; other site 465817001860 ATP binding site [chemical binding]; other site 465817001861 Walker B motif; other site 465817001862 FHA domain; Region: FHA; pfam00498 465817001863 phosphopeptide binding site; other site 465817001864 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 465817001865 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 465817001866 FHIPEP family; Region: FHIPEP; pfam00771 465817001867 HrpJ-like domain; Region: HrpJ; pfam07201 465817001868 TyeA; Region: TyeA; cl07611 465817001869 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 465817001870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817001871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 465817001872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817001873 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 465817001874 putative active site [active] 465817001875 heme pocket [chemical binding]; other site 465817001876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817001877 putative active site [active] 465817001878 heme pocket [chemical binding]; other site 465817001879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 465817001880 Histidine kinase; Region: HisKA_3; pfam07730 465817001881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817001882 ATP binding site [chemical binding]; other site 465817001883 Mg2+ binding site [ion binding]; other site 465817001884 G-X-G motif; other site 465817001885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817001886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817001887 active site 465817001888 phosphorylation site [posttranslational modification] 465817001889 intermolecular recognition site; other site 465817001890 dimerization interface [polypeptide binding]; other site 465817001891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817001892 DNA binding residues [nucleotide binding] 465817001893 dimerization interface [polypeptide binding]; other site 465817001894 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 465817001895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817001896 Walker A motif; other site 465817001897 ATP binding site [chemical binding]; other site 465817001898 Walker B motif; other site 465817001899 arginine finger; other site 465817001900 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 465817001901 Type III secretion needle MxiH like; Region: MxiH; pfam09392 465817001902 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 465817001903 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 465817001904 Flagellar assembly protein FliH; Region: FliH; pfam02108 465817001905 HrpF protein; Region: HrpF; pfam06266 465817001906 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 465817001907 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817001908 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817001909 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 465817001910 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 465817001911 HrpZ; Region: Hairpins; pfam04877 465817001912 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 465817001913 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 465817001914 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 465817001915 Pectate lyase; Region: Pectate_lyase; pfam03211 465817001916 Right handed beta helix region; Region: Beta_helix; pfam13229 465817001917 Pathogenicity factor; Region: AvrE; pfam11725 465817001918 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 465817001919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817001920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817001921 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 465817001922 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817001923 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817001924 silverDB:etchr00549 465817001925 silverDB:etchr00550 465817001926 integrase; Provisional; Region: int; PHA02601 465817001927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465817001928 active site 465817001929 DNA binding site [nucleotide binding] 465817001930 Int/Topo IB signature motif; other site 465817001931 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 465817001932 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 465817001933 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 465817001934 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 465817001935 DksA-like zinc finger domain containing protein; Region: PHA00080 465817001936 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 465817001937 silverDB:etchr00559 465817001938 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 465817001939 silverDB:etchr10006 465817001940 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 465817001941 portal vertex protein; Provisional; Region: Q; PHA02536 465817001942 Phage portal protein; Region: Phage_portal; pfam04860 465817001943 terminase ATPase subunit; Provisional; Region: P; PHA02535 465817001944 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 465817001945 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 465817001946 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 465817001947 capsid protein; Provisional; Region: N; PHA02538 465817001948 terminase endonuclease subunit; Provisional; Region: M; PHA02537 465817001949 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 465817001950 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 465817001951 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 465817001952 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 465817001953 catalytic residues [active] 465817001954 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 465817001955 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 465817001956 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 465817001957 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 465817001958 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 465817001959 baseplate wedge subunit; Provisional; Region: W; PHA02516 465817001960 baseplate assembly protein; Provisional; Region: J; PHA02568 465817001961 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 465817001962 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 465817001963 Phage Tail Collar Domain; Region: Collar; pfam07484 465817001964 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 465817001965 major tail sheath protein; Provisional; Region: FI; PHA02560 465817001966 major tail tube protein; Provisional; Region: FII; PHA02600 465817001967 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 465817001968 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 465817001969 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 465817001970 Phage protein U [General function prediction only]; Region: COG3499 465817001971 tail protein; Provisional; Region: D; PHA02561 465817001972 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 465817001973 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 465817001974 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 465817001975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817001976 metabolite-proton symporter; Region: 2A0106; TIGR00883 465817001977 putative substrate translocation pore; other site 465817001978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817001979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817001980 DNA binding site [nucleotide binding] 465817001981 domain linker motif; other site 465817001982 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 465817001983 dimerization interface [polypeptide binding]; other site 465817001984 ligand binding site [chemical binding]; other site 465817001985 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 465817001986 active site 465817001987 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 465817001988 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 465817001989 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 465817001990 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 465817001991 putative sialic acid transporter; Region: 2A0112; TIGR00891 465817001992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817001993 putative substrate translocation pore; other site 465817001994 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817001995 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817001996 metal binding site [ion binding]; metal-binding site 465817001997 active site 465817001998 I-site; other site 465817001999 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 465817002000 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 465817002001 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 465817002002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817002003 S-adenosylmethionine binding site [chemical binding]; other site 465817002004 DNA polymerase III subunit psi; Validated; Region: PRK06856 465817002005 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 465817002006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817002007 Coenzyme A binding pocket [chemical binding]; other site 465817002008 dUMP phosphatase; Provisional; Region: PRK09449 465817002009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817002010 motif II; other site 465817002011 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 465817002012 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 465817002013 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 465817002014 hypothetical protein; Provisional; Region: PRK07033 465817002015 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 465817002016 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 465817002017 ligand binding site [chemical binding]; other site 465817002018 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 465817002019 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 465817002020 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 465817002021 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 465817002022 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 465817002023 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 465817002024 Protein of unknown function (DUF770); Region: DUF770; pfam05591 465817002025 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 465817002026 Protein of unknown function (DUF877); Region: DUF877; pfam05943 465817002027 Protein of unknown function (DUF796); Region: DUF796; pfam05638 465817002028 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 465817002029 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 465817002030 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 465817002031 phosphopeptide binding site; other site 465817002032 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 465817002033 Protein phosphatase 2C; Region: PP2C; pfam00481 465817002034 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 465817002035 active site 465817002036 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 465817002037 ImpE protein; Region: ImpE; pfam07024 465817002038 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 465817002039 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 465817002040 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 465817002041 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 465817002042 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 465817002043 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 465817002044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817002045 Walker A motif; other site 465817002046 ATP binding site [chemical binding]; other site 465817002047 Walker B motif; other site 465817002048 arginine finger; other site 465817002049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817002050 Walker A motif; other site 465817002051 ATP binding site [chemical binding]; other site 465817002052 Walker B motif; other site 465817002053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 465817002054 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 465817002055 Catalytic domain of Protein Kinases; Region: PKc; cd00180 465817002056 active site 465817002057 ATP binding site [chemical binding]; other site 465817002058 substrate binding site [chemical binding]; other site 465817002059 activation loop (A-loop); other site 465817002060 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 465817002061 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 465817002062 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 465817002063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 465817002064 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 465817002065 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 465817002066 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 465817002067 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 465817002068 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 465817002069 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 465817002070 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 465817002071 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 465817002072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 465817002073 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 465817002074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 465817002075 RHS Repeat; Region: RHS_repeat; pfam05593 465817002076 RHS Repeat; Region: RHS_repeat; pfam05593 465817002077 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817002078 RHS Repeat; Region: RHS_repeat; cl11982 465817002079 RHS protein; Region: RHS; pfam03527 465817002080 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817002081 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 465817002082 RHS protein; Region: RHS; pfam03527 465817002083 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817002084 Fimbrial protein; Region: Fimbrial; pfam00419 465817002085 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 465817002086 PapC N-terminal domain; Region: PapC_N; pfam13954 465817002087 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817002088 PapC C-terminal domain; Region: PapC_C; pfam13953 465817002089 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817002090 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817002091 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817002092 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817002093 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817002094 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817002095 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 465817002096 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 465817002097 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 465817002098 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 465817002099 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 465817002100 G1 box; other site 465817002101 putative GEF interaction site [polypeptide binding]; other site 465817002102 GTP/Mg2+ binding site [chemical binding]; other site 465817002103 Switch I region; other site 465817002104 G2 box; other site 465817002105 G3 box; other site 465817002106 Switch II region; other site 465817002107 G4 box; other site 465817002108 G5 box; other site 465817002109 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 465817002110 periplasmic protein; Provisional; Region: PRK10568 465817002111 BON domain; Region: BON; pfam04972 465817002112 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 465817002113 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 465817002114 active site 465817002115 nucleophile elbow; other site 465817002116 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 465817002117 active site 465817002118 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 465817002119 intersubunit interface [polypeptide binding]; other site 465817002120 active site 465817002121 catalytic residue [active] 465817002122 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 465817002123 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 465817002124 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 465817002125 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 465817002126 phosphopentomutase; Provisional; Region: PRK05362 465817002127 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 465817002128 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 465817002129 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 465817002130 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 465817002131 HipA-like N-terminal domain; Region: HipA_N; pfam07805 465817002132 HipA-like C-terminal domain; Region: HipA_C; pfam07804 465817002133 hypothetical protein; Provisional; Region: PRK11246 465817002134 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 465817002135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817002136 motif II; other site 465817002137 DNA repair protein RadA; Region: sms; TIGR00416 465817002138 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 465817002139 Walker A motif/ATP binding site; other site 465817002140 ATP binding site [chemical binding]; other site 465817002141 Walker B motif; other site 465817002142 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 465817002143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817002144 non-specific DNA binding site [nucleotide binding]; other site 465817002145 salt bridge; other site 465817002146 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 465817002147 sequence-specific DNA binding site [nucleotide binding]; other site 465817002148 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 465817002149 active site 465817002150 (T/H)XGH motif; other site 465817002151 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 465817002152 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 465817002153 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 465817002154 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 465817002155 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 465817002156 putative NAD(P) binding site [chemical binding]; other site 465817002157 dimer interface [polypeptide binding]; other site 465817002158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817002159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817002160 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817002161 putative effector binding pocket; other site 465817002162 dimerization interface [polypeptide binding]; other site 465817002163 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 465817002164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817002165 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817002166 ABC transporter; Region: ABC_tran_2; pfam12848 465817002167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817002168 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 465817002169 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 465817002170 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 465817002171 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 465817002172 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 465817002173 Walker A/P-loop; other site 465817002174 ATP binding site [chemical binding]; other site 465817002175 Q-loop/lid; other site 465817002176 ABC transporter signature motif; other site 465817002177 Walker B; other site 465817002178 D-loop; other site 465817002179 H-loop/switch region; other site 465817002180 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 465817002181 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 465817002182 Walker A/P-loop; other site 465817002183 ATP binding site [chemical binding]; other site 465817002184 Q-loop/lid; other site 465817002185 ABC transporter signature motif; other site 465817002186 Walker B; other site 465817002187 D-loop; other site 465817002188 H-loop/switch region; other site 465817002189 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 465817002190 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 465817002191 TM-ABC transporter signature motif; other site 465817002192 HEAT repeats; Region: HEAT_2; pfam13646 465817002193 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 465817002194 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817002195 TM-ABC transporter signature motif; other site 465817002196 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 465817002197 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 465817002198 putative ligand binding site [chemical binding]; other site 465817002199 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465817002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817002201 DNA-binding site [nucleotide binding]; DNA binding site 465817002202 FCD domain; Region: FCD; pfam07729 465817002203 urea carboxylase; Region: urea_carbox; TIGR02712 465817002204 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465817002205 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465817002206 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 465817002207 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 465817002208 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 465817002209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 465817002210 carboxyltransferase (CT) interaction site; other site 465817002211 biotinylation site [posttranslational modification]; other site 465817002212 allophanate hydrolase; Provisional; Region: PRK08186 465817002213 Amidase; Region: Amidase; cl11426 465817002214 lytic murein transglycosylase; Provisional; Region: PRK11619 465817002215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817002216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817002217 catalytic residue [active] 465817002218 Trp operon repressor; Provisional; Region: PRK01381 465817002219 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 465817002220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465817002221 catalytic core [active] 465817002222 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 465817002223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817002224 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 465817002225 hypothetical protein; Provisional; Region: PRK10756 465817002226 CreA protein; Region: CreA; pfam05981 465817002227 two-component response regulator; Provisional; Region: PRK11173 465817002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817002229 active site 465817002230 phosphorylation site [posttranslational modification] 465817002231 intermolecular recognition site; other site 465817002232 dimerization interface [polypeptide binding]; other site 465817002233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817002234 DNA binding site [nucleotide binding] 465817002235 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 465817002236 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 465817002237 putative catalytic residues [active] 465817002238 putative nucleotide binding site [chemical binding]; other site 465817002239 putative aspartate binding site [chemical binding]; other site 465817002240 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 465817002241 dimer interface [polypeptide binding]; other site 465817002242 putative threonine allosteric regulatory site; other site 465817002243 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 465817002244 putative threonine allosteric regulatory site; other site 465817002245 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 465817002246 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 465817002247 homoserine kinase; Provisional; Region: PRK01212 465817002248 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 465817002249 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 465817002250 threonine synthase; Validated; Region: PRK09225 465817002251 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 465817002252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817002253 catalytic residue [active] 465817002254 hypothetical protein; Validated; Region: PRK02101 465817002255 transaldolase-like protein; Provisional; Region: PTZ00411 465817002256 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 465817002257 active site 465817002258 dimer interface [polypeptide binding]; other site 465817002259 catalytic residue [active] 465817002260 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 465817002261 MPT binding site; other site 465817002262 trimer interface [polypeptide binding]; other site 465817002263 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 465817002264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 465817002265 nucleotide binding site [chemical binding]; other site 465817002266 chaperone protein DnaJ; Provisional; Region: PRK10767 465817002267 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465817002268 HSP70 interaction site [polypeptide binding]; other site 465817002269 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 465817002270 substrate binding site [polypeptide binding]; other site 465817002271 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 465817002272 Zn binding sites [ion binding]; other site 465817002273 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 465817002274 dimer interface [polypeptide binding]; other site 465817002275 Bor protein; Region: Lambda_Bor; pfam06291 465817002276 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 465817002277 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 465817002278 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 465817002279 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 465817002280 active site 465817002281 Riboflavin kinase; Region: Flavokinase; smart00904 465817002282 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 465817002283 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465817002284 active site 465817002285 HIGH motif; other site 465817002286 nucleotide binding site [chemical binding]; other site 465817002287 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 465817002288 active site 465817002289 KMSKS motif; other site 465817002290 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 465817002291 tRNA binding surface [nucleotide binding]; other site 465817002292 anticodon binding site; other site 465817002293 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 465817002294 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 465817002295 lipoprotein signal peptidase; Provisional; Region: PRK14787 465817002296 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 465817002297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817002298 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 465817002299 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 465817002300 dihydrodipicolinate reductase; Provisional; Region: PRK00048 465817002301 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 465817002302 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 465817002303 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 465817002304 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 465817002305 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 465817002306 catalytic site [active] 465817002307 subunit interface [polypeptide binding]; other site 465817002308 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 465817002309 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465817002310 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 465817002311 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 465817002312 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 465817002313 ATP-grasp domain; Region: ATP-grasp_4; cl17255 465817002314 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 465817002315 IMP binding site; other site 465817002316 dimer interface [polypeptide binding]; other site 465817002317 interdomain contacts; other site 465817002318 partial ornithine binding site; other site 465817002319 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817002320 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 465817002321 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 465817002322 folate binding site [chemical binding]; other site 465817002323 NADP+ binding site [chemical binding]; other site 465817002324 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 465817002325 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 465817002326 active site 465817002327 metal binding site [ion binding]; metal-binding site 465817002328 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 465817002329 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 465817002330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817002331 S-adenosylmethionine binding site [chemical binding]; other site 465817002332 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 465817002333 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 465817002334 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 465817002335 SurA N-terminal domain; Region: SurA_N; pfam09312 465817002336 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 465817002337 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 465817002338 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 465817002339 OstA-like protein; Region: OstA; pfam03968 465817002340 Organic solvent tolerance protein; Region: OstA_C; pfam04453 465817002341 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 465817002342 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 465817002343 putative metal binding site [ion binding]; other site 465817002344 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465817002345 HSP70 interaction site [polypeptide binding]; other site 465817002346 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 465817002347 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 465817002348 active site 465817002349 ATP-dependent helicase HepA; Validated; Region: PRK04914 465817002350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817002351 ATP binding site [chemical binding]; other site 465817002352 putative Mg++ binding site [ion binding]; other site 465817002353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817002354 nucleotide binding region [chemical binding]; other site 465817002355 ATP-binding site [chemical binding]; other site 465817002356 DNA polymerase II; Reviewed; Region: PRK05762 465817002357 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 465817002358 active site 465817002359 catalytic site [active] 465817002360 substrate binding site [chemical binding]; other site 465817002361 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 465817002362 active site 465817002363 metal-binding site 465817002364 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 465817002365 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465817002366 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 465817002367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817002368 Walker A/P-loop; other site 465817002369 ATP binding site [chemical binding]; other site 465817002370 Q-loop/lid; other site 465817002371 ABC transporter signature motif; other site 465817002372 Walker B; other site 465817002373 D-loop; other site 465817002374 H-loop/switch region; other site 465817002375 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 465817002376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817002377 dimer interface [polypeptide binding]; other site 465817002378 conserved gate region; other site 465817002379 putative PBP binding loops; other site 465817002380 ABC-ATPase subunit interface; other site 465817002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817002382 dimer interface [polypeptide binding]; other site 465817002383 conserved gate region; other site 465817002384 putative PBP binding loops; other site 465817002385 ABC-ATPase subunit interface; other site 465817002386 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 465817002387 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 465817002388 transcriptional regulator SgrR; Provisional; Region: PRK13626 465817002389 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 465817002390 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 465817002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817002392 sugar efflux transporter; Region: 2A0120; TIGR00899 465817002393 putative substrate translocation pore; other site 465817002394 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 465817002395 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 465817002396 substrate binding site [chemical binding]; other site 465817002397 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 465817002398 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 465817002399 substrate binding site [chemical binding]; other site 465817002400 ligand binding site [chemical binding]; other site 465817002401 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 465817002402 tartrate dehydrogenase; Region: TTC; TIGR02089 465817002403 2-isopropylmalate synthase; Validated; Region: PRK00915 465817002404 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 465817002405 active site 465817002406 catalytic residues [active] 465817002407 metal binding site [ion binding]; metal-binding site 465817002408 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 465817002409 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 465817002410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465817002411 PYR/PP interface [polypeptide binding]; other site 465817002412 dimer interface [polypeptide binding]; other site 465817002413 TPP binding site [chemical binding]; other site 465817002414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817002415 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 465817002416 TPP-binding site [chemical binding]; other site 465817002417 dimer interface [polypeptide binding]; other site 465817002418 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 465817002419 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 465817002420 putative valine binding site [chemical binding]; other site 465817002421 dimer interface [polypeptide binding]; other site 465817002422 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 465817002423 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 465817002424 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817002425 DNA binding site [nucleotide binding] 465817002426 domain linker motif; other site 465817002427 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 465817002428 dimerization interface [polypeptide binding]; other site 465817002429 ligand binding site [chemical binding]; other site 465817002430 cell division protein MraZ; Reviewed; Region: PRK00326 465817002431 MraZ protein; Region: MraZ; pfam02381 465817002432 MraZ protein; Region: MraZ; pfam02381 465817002433 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 465817002434 MraW methylase family; Region: Methyltransf_5; pfam01795 465817002435 cell division protein FtsL; Provisional; Region: PRK10772 465817002436 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 465817002437 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 465817002438 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 465817002439 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 465817002440 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465817002441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817002442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465817002443 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 465817002444 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465817002445 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817002446 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 465817002447 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 465817002448 Mg++ binding site [ion binding]; other site 465817002449 putative catalytic motif [active] 465817002450 putative substrate binding site [chemical binding]; other site 465817002451 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 465817002452 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 465817002453 NAD(P) binding pocket [chemical binding]; other site 465817002454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817002455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465817002456 cell division protein FtsW; Provisional; Region: PRK10774 465817002457 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 465817002458 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 465817002459 active site 465817002460 homodimer interface [polypeptide binding]; other site 465817002461 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 465817002462 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465817002463 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817002464 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465817002465 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 465817002466 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 465817002467 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 465817002468 cell division protein FtsQ; Provisional; Region: PRK10775 465817002469 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 465817002470 Cell division protein FtsQ; Region: FtsQ; pfam03799 465817002471 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 465817002472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465817002473 Cell division protein FtsA; Region: FtsA; pfam14450 465817002474 cell division protein FtsZ; Validated; Region: PRK09330 465817002475 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 465817002476 nucleotide binding site [chemical binding]; other site 465817002477 SulA interaction site; other site 465817002478 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 465817002479 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 465817002480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 465817002481 SecA regulator SecM; Provisional; Region: PRK02943 465817002482 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 465817002483 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 465817002484 SEC-C motif; Region: SEC-C; pfam02810 465817002485 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 465817002486 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 465817002487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817002488 PAS fold; Region: PAS_3; pfam08447 465817002489 putative active site [active] 465817002490 heme pocket [chemical binding]; other site 465817002491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817002492 putative CheW interface [polypeptide binding]; other site 465817002493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817002494 S-adenosylmethionine binding site [chemical binding]; other site 465817002495 choline transport protein BetT; Provisional; Region: PRK09928 465817002496 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 465817002497 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 465817002498 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 465817002499 thiS-thiF/thiG interaction site; other site 465817002500 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 465817002501 ThiS interaction site; other site 465817002502 putative active site [active] 465817002503 tetramer interface [polypeptide binding]; other site 465817002504 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 465817002505 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 465817002506 ATP binding site [chemical binding]; other site 465817002507 substrate interface [chemical binding]; other site 465817002508 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 465817002509 active site residue [active] 465817002510 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 465817002511 Sensors of blue-light using FAD; Region: BLUF; pfam04940 465817002512 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817002513 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 465817002514 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 465817002515 NAD(P) binding site [chemical binding]; other site 465817002516 catalytic residues [active] 465817002517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817002518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817002519 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 465817002520 putative dimerization interface [polypeptide binding]; other site 465817002521 methionine sulfoxide reductase A; Provisional; Region: PRK14054 465817002522 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 465817002523 Chitin binding domain; Region: Chitin_bind_3; pfam03067 465817002524 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 465817002525 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 465817002526 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 465817002527 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 465817002528 GspL periplasmic domain; Region: GspL_C; cl14909 465817002529 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 465817002530 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 465817002531 type II secretion system protein J; Region: gspJ; TIGR01711 465817002532 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 465817002533 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 465817002534 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 465817002535 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 465817002536 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 465817002537 type II secretion system protein F; Region: GspF; TIGR02120 465817002538 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465817002539 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465817002540 type II secretion system protein E; Region: type_II_gspE; TIGR02533 465817002541 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 465817002542 Walker A motif; other site 465817002543 ATP binding site [chemical binding]; other site 465817002544 Walker B motif; other site 465817002545 type II secretion system protein D; Region: type_II_gspD; TIGR02517 465817002546 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817002547 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817002548 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817002549 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 465817002550 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 465817002551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817002552 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 465817002553 active site 465817002554 8-oxo-dGMP binding site [chemical binding]; other site 465817002555 nudix motif; other site 465817002556 metal binding site [ion binding]; metal-binding site 465817002557 DNA gyrase inhibitor; Reviewed; Region: PRK00418 465817002558 hypothetical protein; Provisional; Region: PRK05287 465817002559 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 465817002560 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 465817002561 CoA-binding site [chemical binding]; other site 465817002562 ATP-binding [chemical binding]; other site 465817002563 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 465817002564 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 465817002565 active site 465817002566 type IV pilin biogenesis protein; Provisional; Region: PRK10573 465817002567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465817002568 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465817002569 hypothetical protein; Provisional; Region: PRK10436 465817002570 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 465817002571 Walker A motif; other site 465817002572 ATP binding site [chemical binding]; other site 465817002573 Walker B motif; other site 465817002574 putative major pilin subunit; Provisional; Region: PRK10574 465817002575 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 465817002576 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 465817002577 dimerization interface [polypeptide binding]; other site 465817002578 active site 465817002579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817002580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817002581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817002582 dimerization interface [polypeptide binding]; other site 465817002583 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 465817002584 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 465817002585 amidase catalytic site [active] 465817002586 Zn binding residues [ion binding]; other site 465817002587 substrate binding site [chemical binding]; other site 465817002588 regulatory protein AmpE; Provisional; Region: PRK10987 465817002589 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 465817002590 active site 465817002591 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 465817002592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817002593 putative substrate translocation pore; other site 465817002594 aromatic amino acid transporter; Provisional; Region: PRK10238 465817002595 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 465817002596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817002597 DNA-binding site [nucleotide binding]; DNA binding site 465817002598 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 465817002599 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 465817002600 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 465817002601 dimer interface [polypeptide binding]; other site 465817002602 TPP-binding site [chemical binding]; other site 465817002603 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 465817002604 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465817002605 E3 interaction surface; other site 465817002606 lipoyl attachment site [posttranslational modification]; other site 465817002607 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465817002608 E3 interaction surface; other site 465817002609 lipoyl attachment site [posttranslational modification]; other site 465817002610 e3 binding domain; Region: E3_binding; pfam02817 465817002611 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465817002612 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 465817002613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465817002614 late expression factor 9; Provisional; Region: lef-9; PHA03396 465817002615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817002616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465817002617 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 465817002618 classical (c) SDRs; Region: SDR_c; cd05233 465817002619 NAD(P) binding site [chemical binding]; other site 465817002620 active site 465817002621 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 465817002622 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 465817002623 Walker A/P-loop; other site 465817002624 ATP binding site [chemical binding]; other site 465817002625 Q-loop/lid; other site 465817002626 ABC transporter signature motif; other site 465817002627 Walker B; other site 465817002628 D-loop; other site 465817002629 H-loop/switch region; other site 465817002630 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 465817002631 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 465817002632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 465817002633 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 465817002634 NADP binding site [chemical binding]; other site 465817002635 dimer interface [polypeptide binding]; other site 465817002636 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465817002637 active site 465817002638 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 465817002639 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 465817002640 acyl-activating enzyme (AAE) consensus motif; other site 465817002641 AMP binding site [chemical binding]; other site 465817002642 active site 465817002643 CoA binding site [chemical binding]; other site 465817002644 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 465817002645 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465817002646 dimer interface [polypeptide binding]; other site 465817002647 active site 465817002648 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 465817002649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465817002650 substrate binding site [chemical binding]; other site 465817002651 oxyanion hole (OAH) forming residues; other site 465817002652 trimer interface [polypeptide binding]; other site 465817002653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817002654 DNA binding site [nucleotide binding] 465817002655 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 465817002656 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 465817002657 substrate binding site [chemical binding]; other site 465817002658 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 465817002659 substrate binding site [chemical binding]; other site 465817002660 ligand binding site [chemical binding]; other site 465817002661 hypothetical protein; Provisional; Region: PRK05248 465817002662 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 465817002663 spermidine synthase; Provisional; Region: PRK00811 465817002664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817002665 S-adenosylmethionine binding site [chemical binding]; other site 465817002666 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 465817002667 multicopper oxidase; Provisional; Region: PRK10965 465817002668 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 465817002669 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 465817002670 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 465817002671 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 465817002672 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 465817002673 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 465817002674 Protein of unknown function (DUF497); Region: DUF497; pfam04365 465817002675 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 465817002676 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 465817002677 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 465817002678 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 465817002679 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 465817002680 PAS fold; Region: PAS_4; pfam08448 465817002681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817002682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817002683 DNA binding residues [nucleotide binding] 465817002684 dimerization interface [polypeptide binding]; other site 465817002685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817002687 DNA binding residues [nucleotide binding] 465817002688 dimerization interface [polypeptide binding]; other site 465817002689 methionine gamma-lyase; Validated; Region: PRK07049 465817002690 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 465817002691 homodimer interface [polypeptide binding]; other site 465817002692 substrate-cofactor binding pocket; other site 465817002693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817002694 catalytic residue [active] 465817002695 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 465817002696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817002697 active site 465817002698 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 465817002699 active site clefts [active] 465817002700 zinc binding site [ion binding]; other site 465817002701 dimer interface [polypeptide binding]; other site 465817002702 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 465817002703 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 465817002704 Walker A/P-loop; other site 465817002705 ATP binding site [chemical binding]; other site 465817002706 Q-loop/lid; other site 465817002707 ABC transporter signature motif; other site 465817002708 Walker B; other site 465817002709 D-loop; other site 465817002710 H-loop/switch region; other site 465817002711 inner membrane transport permease; Provisional; Region: PRK15066 465817002712 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 465817002713 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 465817002714 tetramerization interface [polypeptide binding]; other site 465817002715 active site 465817002716 Pantoate-beta-alanine ligase; Region: PanC; cd00560 465817002717 pantoate--beta-alanine ligase; Region: panC; TIGR00018 465817002718 active site 465817002719 ATP-binding site [chemical binding]; other site 465817002720 pantoate-binding site; other site 465817002721 HXXH motif; other site 465817002722 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 465817002723 oligomerization interface [polypeptide binding]; other site 465817002724 active site 465817002725 metal binding site [ion binding]; metal-binding site 465817002726 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 465817002727 catalytic center binding site [active] 465817002728 ATP binding site [chemical binding]; other site 465817002729 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 465817002730 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 465817002731 active site 465817002732 NTP binding site [chemical binding]; other site 465817002733 metal binding triad [ion binding]; metal-binding site 465817002734 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 465817002735 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 465817002736 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 465817002737 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 465817002738 active site 465817002739 nucleotide binding site [chemical binding]; other site 465817002740 HIGH motif; other site 465817002741 KMSKS motif; other site 465817002742 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 465817002743 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 465817002744 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 465817002745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817002746 ATP binding site [chemical binding]; other site 465817002747 putative Mg++ binding site [ion binding]; other site 465817002748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817002749 nucleotide binding region [chemical binding]; other site 465817002750 ATP-binding site [chemical binding]; other site 465817002751 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 465817002752 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 465817002753 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 465817002754 Transglycosylase; Region: Transgly; pfam00912 465817002755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 465817002756 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 465817002757 PAAR motif; Region: PAAR_motif; pfam05488 465817002758 RHS Repeat; Region: RHS_repeat; pfam05593 465817002759 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817002760 RHS Repeat; Region: RHS_repeat; pfam05593 465817002761 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 465817002762 RHS Repeat; Region: RHS_repeat; cl11982 465817002763 RHS Repeat; Region: RHS_repeat; pfam05593 465817002764 RHS protein; Region: RHS; pfam03527 465817002765 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817002766 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 465817002767 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 465817002768 RHS protein; Region: RHS; pfam03527 465817002769 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817002770 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817002771 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 465817002772 RHS protein; Region: RHS; pfam03527 465817002773 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817002774 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817002775 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 465817002776 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817002777 N-terminal plug; other site 465817002778 ligand-binding site [chemical binding]; other site 465817002779 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 465817002780 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465817002781 Walker A/P-loop; other site 465817002782 ATP binding site [chemical binding]; other site 465817002783 Q-loop/lid; other site 465817002784 ABC transporter signature motif; other site 465817002785 Walker B; other site 465817002786 D-loop; other site 465817002787 H-loop/switch region; other site 465817002788 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 465817002789 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 465817002790 siderophore binding site; other site 465817002791 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817002792 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817002793 ABC-ATPase subunit interface; other site 465817002794 dimer interface [polypeptide binding]; other site 465817002795 putative PBP binding regions; other site 465817002796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817002797 ABC-ATPase subunit interface; other site 465817002798 dimer interface [polypeptide binding]; other site 465817002799 putative PBP binding regions; other site 465817002800 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 465817002801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817002802 inhibitor-cofactor binding pocket; inhibition site 465817002803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817002804 catalytic residue [active] 465817002805 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 465817002806 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 465817002807 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 465817002808 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 465817002809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465817002810 Zn2+ binding site [ion binding]; other site 465817002811 Mg2+ binding site [ion binding]; other site 465817002812 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 465817002813 serine endoprotease; Provisional; Region: PRK10942 465817002814 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 465817002815 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465817002816 protein binding site [polypeptide binding]; other site 465817002817 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 465817002818 protein binding site [polypeptide binding]; other site 465817002819 hypothetical protein; Provisional; Region: PRK13677 465817002820 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 465817002821 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 465817002822 trimer interface [polypeptide binding]; other site 465817002823 active site 465817002824 substrate binding site [chemical binding]; other site 465817002825 CoA binding site [chemical binding]; other site 465817002826 PII uridylyl-transferase; Provisional; Region: PRK05007 465817002827 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 465817002828 metal binding triad; other site 465817002829 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 465817002830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465817002831 Zn2+ binding site [ion binding]; other site 465817002832 Mg2+ binding site [ion binding]; other site 465817002833 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 465817002834 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 465817002835 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 465817002836 active site 465817002837 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 465817002838 rRNA interaction site [nucleotide binding]; other site 465817002839 S8 interaction site; other site 465817002840 putative laminin-1 binding site; other site 465817002841 elongation factor Ts; Provisional; Region: tsf; PRK09377 465817002842 UBA/TS-N domain; Region: UBA; pfam00627 465817002843 Elongation factor TS; Region: EF_TS; pfam00889 465817002844 Elongation factor TS; Region: EF_TS; pfam00889 465817002845 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 465817002846 putative nucleotide binding site [chemical binding]; other site 465817002847 uridine monophosphate binding site [chemical binding]; other site 465817002848 homohexameric interface [polypeptide binding]; other site 465817002849 ribosome recycling factor; Reviewed; Region: frr; PRK00083 465817002850 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 465817002851 hinge region; other site 465817002852 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 465817002853 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 465817002854 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 465817002855 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 465817002856 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 465817002857 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 465817002858 catalytic residue [active] 465817002859 putative FPP diphosphate binding site; other site 465817002860 putative FPP binding hydrophobic cleft; other site 465817002861 dimer interface [polypeptide binding]; other site 465817002862 putative IPP diphosphate binding site; other site 465817002863 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 465817002864 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 465817002865 zinc metallopeptidase RseP; Provisional; Region: PRK10779 465817002866 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 465817002867 active site 465817002868 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 465817002869 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 465817002870 protein binding site [polypeptide binding]; other site 465817002871 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 465817002872 putative substrate binding region [chemical binding]; other site 465817002873 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 465817002874 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817002875 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817002876 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817002877 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817002878 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817002879 Surface antigen; Region: Bac_surface_Ag; pfam01103 465817002880 periplasmic chaperone; Provisional; Region: PRK10780 465817002881 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 465817002882 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 465817002883 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 465817002884 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 465817002885 trimer interface [polypeptide binding]; other site 465817002886 active site 465817002887 UDP-GlcNAc binding site [chemical binding]; other site 465817002888 lipid binding site [chemical binding]; lipid-binding site 465817002889 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 465817002890 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 465817002891 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 465817002892 active site 465817002893 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 465817002894 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 465817002895 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 465817002896 RNA/DNA hybrid binding site [nucleotide binding]; other site 465817002897 active site 465817002898 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 465817002899 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 465817002900 putative active site [active] 465817002901 putative PHP Thumb interface [polypeptide binding]; other site 465817002902 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 465817002903 generic binding surface II; other site 465817002904 generic binding surface I; other site 465817002905 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 465817002906 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 465817002907 lysine decarboxylase LdcC; Provisional; Region: PRK15399 465817002908 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 465817002909 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 465817002910 homodimer interface [polypeptide binding]; other site 465817002911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817002912 catalytic residue [active] 465817002913 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 465817002914 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 465817002915 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 465817002916 putative metal binding site [ion binding]; other site 465817002917 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 465817002918 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 465817002919 Ligand Binding Site [chemical binding]; other site 465817002920 TilS substrate binding domain; Region: TilS; pfam09179 465817002921 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 465817002922 Cytochrome c553 [Energy production and conversion]; Region: COG2863 465817002923 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 465817002924 YaeQ protein; Region: YaeQ; pfam07152 465817002925 hypothetical protein; Provisional; Region: PRK09256 465817002926 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 465817002927 prolyl-tRNA synthetase; Provisional; Region: PRK09194 465817002928 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 465817002929 dimer interface [polypeptide binding]; other site 465817002930 motif 1; other site 465817002931 active site 465817002932 motif 2; other site 465817002933 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 465817002934 putative deacylase active site [active] 465817002935 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465817002936 active site 465817002937 motif 3; other site 465817002938 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 465817002939 anticodon binding site; other site 465817002940 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 465817002941 homodimer interaction site [polypeptide binding]; other site 465817002942 cofactor binding site; other site 465817002943 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 465817002944 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 465817002945 lipoprotein, YaeC family; Region: TIGR00363 465817002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817002947 dimer interface [polypeptide binding]; other site 465817002948 conserved gate region; other site 465817002949 ABC-ATPase subunit interface; other site 465817002950 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 465817002951 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 465817002952 Walker A/P-loop; other site 465817002953 ATP binding site [chemical binding]; other site 465817002954 Q-loop/lid; other site 465817002955 ABC transporter signature motif; other site 465817002956 Walker B; other site 465817002957 D-loop; other site 465817002958 H-loop/switch region; other site 465817002959 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 465817002960 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 465817002961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817002962 active site 465817002963 motif I; other site 465817002964 motif II; other site 465817002965 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 465817002966 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 465817002967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817002968 putative substrate translocation pore; other site 465817002969 lipoprotein; Provisional; Region: PRK10759 465817002970 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 465817002971 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 465817002972 domain interface [polypeptide binding]; other site 465817002973 putative active site [active] 465817002974 catalytic site [active] 465817002975 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 465817002976 domain interface [polypeptide binding]; other site 465817002977 putative active site [active] 465817002978 catalytic site [active] 465817002979 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 465817002980 CoA binding domain; Region: CoA_binding_2; pfam13380 465817002981 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 465817002982 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 465817002983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465817002984 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465817002985 Uncharacterized conserved protein [Function unknown]; Region: COG3148 465817002986 thioredoxin 2; Provisional; Region: PRK10996 465817002987 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 465817002988 catalytic residues [active] 465817002989 putative methyltransferase; Provisional; Region: PRK10864 465817002990 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 465817002991 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465817002992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 465817002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817002994 putative substrate translocation pore; other site 465817002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817002996 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 465817002997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817002998 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817002999 transcriptional repressor MprA; Provisional; Region: PRK10870 465817003000 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 465817003001 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 465817003002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817003003 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 465817003004 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 465817003005 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 465817003006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003007 dimer interface [polypeptide binding]; other site 465817003008 conserved gate region; other site 465817003009 putative PBP binding loops; other site 465817003010 ABC-ATPase subunit interface; other site 465817003011 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 465817003012 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 465817003013 Walker A/P-loop; other site 465817003014 ATP binding site [chemical binding]; other site 465817003015 Q-loop/lid; other site 465817003016 ABC transporter signature motif; other site 465817003017 Walker B; other site 465817003018 D-loop; other site 465817003019 H-loop/switch region; other site 465817003020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 465817003021 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 465817003022 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 465817003023 dimer interface [polypeptide binding]; other site 465817003024 putative radical transfer pathway; other site 465817003025 diiron center [ion binding]; other site 465817003026 tyrosyl radical; other site 465817003027 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 465817003028 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 465817003029 Class I ribonucleotide reductase; Region: RNR_I; cd01679 465817003030 active site 465817003031 dimer interface [polypeptide binding]; other site 465817003032 catalytic residues [active] 465817003033 effector binding site; other site 465817003034 R2 peptide binding site; other site 465817003035 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 465817003036 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 465817003037 catalytic residues [active] 465817003038 hypothetical protein; Provisional; Region: PRK10556 465817003039 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 465817003040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817003041 Coenzyme A binding pocket [chemical binding]; other site 465817003042 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 465817003043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817003044 DNA binding site [nucleotide binding] 465817003045 transcriptional activator FlhD; Provisional; Region: PRK02909 465817003046 transcriptional activator FlhC; Provisional; Region: PRK12722 465817003047 Autoinducer binding domain; Region: Autoind_bind; pfam03472 465817003048 transcriptional regulator TraR; Provisional; Region: PRK13870 465817003049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817003050 DNA binding residues [nucleotide binding] 465817003051 dimerization interface [polypeptide binding]; other site 465817003052 Autoinducer synthetase; Region: Autoind_synth; cl17404 465817003053 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 465817003054 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 465817003055 active site turn [active] 465817003056 phosphorylation site [posttranslational modification] 465817003057 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 465817003058 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 465817003059 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 465817003060 substrate binding [chemical binding]; other site 465817003061 active site 465817003062 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 465817003063 Mig-14; Region: Mig-14; pfam07395 465817003064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 465817003065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465817003066 Transposase; Region: HTH_Tnp_1; pfam01527 465817003067 silverDB:etchr00952 465817003068 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 465817003069 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 465817003070 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 465817003071 cofactor binding site; other site 465817003072 DNA binding site [nucleotide binding] 465817003073 substrate interaction site [chemical binding]; other site 465817003074 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 465817003075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 465817003076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465817003077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003078 ATP binding site [chemical binding]; other site 465817003079 Mg2+ binding site [ion binding]; other site 465817003080 G-X-G motif; other site 465817003081 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 465817003082 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 465817003083 active site 465817003084 Int/Topo IB signature motif; other site 465817003085 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 465817003086 SmpB-tmRNA interface; other site 465817003087 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 465817003088 putative coenzyme Q binding site [chemical binding]; other site 465817003089 hypothetical protein; Validated; Region: PRK01777 465817003090 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 465817003091 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 465817003092 recombination and repair protein; Provisional; Region: PRK10869 465817003093 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 465817003094 Walker A/P-loop; other site 465817003095 ATP binding site [chemical binding]; other site 465817003096 Q-loop/lid; other site 465817003097 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 465817003098 ABC transporter signature motif; other site 465817003099 Walker B; other site 465817003100 D-loop; other site 465817003101 H-loop/switch region; other site 465817003102 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 465817003103 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 465817003104 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 465817003105 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 465817003106 dimer interface [polypeptide binding]; other site 465817003107 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 465817003108 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 465817003109 ligand binding site [chemical binding]; other site 465817003110 active site 465817003111 UGI interface [polypeptide binding]; other site 465817003112 catalytic site [active] 465817003113 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 465817003114 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 465817003115 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465817003116 ATP binding site [chemical binding]; other site 465817003117 Mg++ binding site [ion binding]; other site 465817003118 motif III; other site 465817003119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817003120 nucleotide binding region [chemical binding]; other site 465817003121 ATP-binding site [chemical binding]; other site 465817003122 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 465817003123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817003124 S-adenosylmethionine binding site [chemical binding]; other site 465817003125 L-aspartate oxidase; Provisional; Region: PRK09077 465817003126 L-aspartate oxidase; Provisional; Region: PRK06175 465817003127 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 465817003128 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 465817003129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817003130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817003131 DNA binding residues [nucleotide binding] 465817003132 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 465817003133 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 465817003134 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 465817003135 anti-sigma E factor; Provisional; Region: rseB; PRK09455 465817003136 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 465817003137 SoxR reducing system protein RseC; Provisional; Region: PRK10862 465817003138 Antitermination protein; Region: Antiterm; pfam03589 465817003139 Antitermination protein; Region: Antiterm; pfam03589 465817003140 GTP-binding protein LepA; Provisional; Region: PRK05433 465817003141 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 465817003142 G1 box; other site 465817003143 putative GEF interaction site [polypeptide binding]; other site 465817003144 GTP/Mg2+ binding site [chemical binding]; other site 465817003145 Switch I region; other site 465817003146 G2 box; other site 465817003147 G3 box; other site 465817003148 Switch II region; other site 465817003149 G4 box; other site 465817003150 G5 box; other site 465817003151 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 465817003152 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 465817003153 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 465817003154 signal peptidase I; Provisional; Region: PRK10861 465817003155 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 465817003156 Catalytic site [active] 465817003157 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 465817003158 ribonuclease III; Reviewed; Region: rnc; PRK00102 465817003159 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 465817003160 dimerization interface [polypeptide binding]; other site 465817003161 active site 465817003162 metal binding site [ion binding]; metal-binding site 465817003163 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 465817003164 dsRNA binding site [nucleotide binding]; other site 465817003165 GTPase Era; Reviewed; Region: era; PRK00089 465817003166 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 465817003167 G1 box; other site 465817003168 GTP/Mg2+ binding site [chemical binding]; other site 465817003169 Switch I region; other site 465817003170 G2 box; other site 465817003171 Switch II region; other site 465817003172 G3 box; other site 465817003173 G4 box; other site 465817003174 G5 box; other site 465817003175 KH domain; Region: KH_2; pfam07650 465817003176 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 465817003177 Recombination protein O N terminal; Region: RecO_N; pfam11967 465817003178 Recombination protein O C terminal; Region: RecO_C; pfam02565 465817003179 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 465817003180 active site 465817003181 hydrophilic channel; other site 465817003182 dimerization interface [polypeptide binding]; other site 465817003183 catalytic residues [active] 465817003184 active site lid [active] 465817003185 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 465817003186 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 465817003187 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 465817003188 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 465817003189 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 465817003190 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 465817003191 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 465817003192 putative active site [active] 465817003193 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 465817003194 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 465817003195 putative active site [active] 465817003196 hypothetical protein; Provisional; Region: PRK11590 465817003197 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 465817003198 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 465817003199 nucleoside/Zn binding site; other site 465817003200 dimer interface [polypeptide binding]; other site 465817003201 catalytic motif [active] 465817003202 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 465817003203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817003204 substrate binding pocket [chemical binding]; other site 465817003205 membrane-bound complex binding site; other site 465817003206 hinge residues; other site 465817003207 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817003208 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817003209 catalytic residue [active] 465817003210 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 465817003211 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 465817003212 dimerization interface [polypeptide binding]; other site 465817003213 ATP binding site [chemical binding]; other site 465817003214 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 465817003215 dimerization interface [polypeptide binding]; other site 465817003216 ATP binding site [chemical binding]; other site 465817003217 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 465817003218 putative active site [active] 465817003219 catalytic triad [active] 465817003220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465817003221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817003222 dimer interface [polypeptide binding]; other site 465817003223 phosphorylation site [posttranslational modification] 465817003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003225 ATP binding site [chemical binding]; other site 465817003226 Mg2+ binding site [ion binding]; other site 465817003227 G-X-G motif; other site 465817003228 hypothetical protein; Provisional; Region: PRK10722 465817003229 response regulator GlrR; Provisional; Region: PRK15115 465817003230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003231 active site 465817003232 phosphorylation site [posttranslational modification] 465817003233 intermolecular recognition site; other site 465817003234 dimerization interface [polypeptide binding]; other site 465817003235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817003236 Walker A motif; other site 465817003237 ATP binding site [chemical binding]; other site 465817003238 Walker B motif; other site 465817003239 arginine finger; other site 465817003240 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 465817003241 Nitrogen regulatory protein P-II; Region: P-II; smart00938 465817003242 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 465817003243 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 465817003244 heme-binding site [chemical binding]; other site 465817003245 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 465817003246 FAD binding pocket [chemical binding]; other site 465817003247 FAD binding motif [chemical binding]; other site 465817003248 phosphate binding motif [ion binding]; other site 465817003249 beta-alpha-beta structure motif; other site 465817003250 NAD binding pocket [chemical binding]; other site 465817003251 Heme binding pocket [chemical binding]; other site 465817003252 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 465817003253 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 465817003254 dimer interface [polypeptide binding]; other site 465817003255 active site 465817003256 glycine-pyridoxal phosphate binding site [chemical binding]; other site 465817003257 folate binding site [chemical binding]; other site 465817003258 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 465817003259 PRD domain; Region: PRD; pfam00874 465817003260 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 465817003261 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 465817003262 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 465817003263 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 465817003264 active site 465817003265 dimerization interface [polypeptide binding]; other site 465817003266 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 465817003267 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465817003268 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 465817003269 Rrf2 family protein; Region: rrf2_super; TIGR00738 465817003270 cysteine desulfurase; Provisional; Region: PRK14012 465817003271 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 465817003272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817003273 catalytic residue [active] 465817003274 aminopeptidase B; Provisional; Region: PRK05015 465817003275 Peptidase; Region: DUF3663; pfam12404 465817003276 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 465817003277 interface (dimer of trimers) [polypeptide binding]; other site 465817003278 Substrate-binding/catalytic site; other site 465817003279 Zn-binding sites [ion binding]; other site 465817003280 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 465817003281 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 465817003282 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 465817003283 active site residue [active] 465817003284 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 465817003285 active site residue [active] 465817003286 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 465817003287 active site 465817003288 multimer interface [polypeptide binding]; other site 465817003289 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 465817003290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817003291 FeS/SAM binding site; other site 465817003292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 465817003293 binding surface 465817003294 TPR motif; other site 465817003295 TPR repeat; Region: TPR_11; pfam13414 465817003296 Tetratricopeptide repeat; Region: TPR_12; pfam13424 465817003297 cytoskeletal protein RodZ; Provisional; Region: PRK10856 465817003298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817003299 non-specific DNA binding site [nucleotide binding]; other site 465817003300 salt bridge; other site 465817003301 sequence-specific DNA binding site [nucleotide binding]; other site 465817003302 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 465817003303 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 465817003304 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 465817003305 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 465817003306 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 465817003307 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 465817003308 dimer interface [polypeptide binding]; other site 465817003309 motif 1; other site 465817003310 active site 465817003311 motif 2; other site 465817003312 motif 3; other site 465817003313 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 465817003314 anticodon binding site; other site 465817003315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 465817003316 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 465817003317 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 465817003318 Trp docking motif [polypeptide binding]; other site 465817003319 GTP-binding protein Der; Reviewed; Region: PRK00093 465817003320 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 465817003321 G1 box; other site 465817003322 GTP/Mg2+ binding site [chemical binding]; other site 465817003323 Switch I region; other site 465817003324 G2 box; other site 465817003325 Switch II region; other site 465817003326 G3 box; other site 465817003327 G4 box; other site 465817003328 G5 box; other site 465817003329 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 465817003330 G1 box; other site 465817003331 GTP/Mg2+ binding site [chemical binding]; other site 465817003332 Switch I region; other site 465817003333 G2 box; other site 465817003334 G3 box; other site 465817003335 Switch II region; other site 465817003336 G4 box; other site 465817003337 G5 box; other site 465817003338 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 465817003339 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 465817003340 Trp docking motif [polypeptide binding]; other site 465817003341 putative active site [active] 465817003342 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 465817003343 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 465817003344 generic binding surface II; other site 465817003345 generic binding surface I; other site 465817003346 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 465817003347 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 465817003348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 465817003349 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 465817003350 active site 465817003351 GMP synthase; Reviewed; Region: guaA; PRK00074 465817003352 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 465817003353 AMP/PPi binding site [chemical binding]; other site 465817003354 candidate oxyanion hole; other site 465817003355 catalytic triad [active] 465817003356 potential glutamine specificity residues [chemical binding]; other site 465817003357 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 465817003358 ATP Binding subdomain [chemical binding]; other site 465817003359 Ligand Binding sites [chemical binding]; other site 465817003360 Dimerization subdomain; other site 465817003361 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 465817003362 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 465817003363 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 465817003364 methionine synthase; Provisional; Region: PRK01207 465817003365 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 465817003366 substrate binding site [chemical binding]; other site 465817003367 THF binding site; other site 465817003368 zinc-binding site [ion binding]; other site 465817003369 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 465817003370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 465817003371 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 465817003372 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 465817003373 active site 465817003374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465817003375 DNA-binding site [nucleotide binding]; DNA binding site 465817003376 RNA-binding motif; other site 465817003377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465817003378 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 465817003379 putative NAD(P) binding site [chemical binding]; other site 465817003380 active site 465817003381 putative substrate binding site [chemical binding]; other site 465817003382 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 465817003383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817003384 putative substrate translocation pore; other site 465817003385 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 465817003386 MgtE intracellular N domain; Region: MgtE_N; smart00924 465817003387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 465817003388 MASE1; Region: MASE1; cl17823 465817003389 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 465817003390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817003391 tellurite resistance protein TehB; Provisional; Region: PRK11207 465817003392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817003393 S-adenosylmethionine binding site [chemical binding]; other site 465817003394 exopolyphosphatase; Provisional; Region: PRK10854 465817003395 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 465817003396 polyphosphate kinase; Provisional; Region: PRK05443 465817003397 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 465817003398 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 465817003399 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 465817003400 putative active site [active] 465817003401 catalytic site [active] 465817003402 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 465817003403 domain interface [polypeptide binding]; other site 465817003404 active site 465817003405 catalytic site [active] 465817003406 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 465817003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003408 conserved gate region; other site 465817003409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003410 dimer interface [polypeptide binding]; other site 465817003411 conserved gate region; other site 465817003412 putative PBP binding loops; other site 465817003413 ABC-ATPase subunit interface; other site 465817003414 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 465817003415 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 465817003416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003417 ABC-ATPase subunit interface; other site 465817003418 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 465817003419 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 465817003420 Walker A/P-loop; other site 465817003421 ATP binding site [chemical binding]; other site 465817003422 Q-loop/lid; other site 465817003423 ABC transporter signature motif; other site 465817003424 Walker B; other site 465817003425 D-loop; other site 465817003426 H-loop/switch region; other site 465817003427 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 465817003428 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 465817003429 active site 465817003430 substrate binding site [chemical binding]; other site 465817003431 cosubstrate binding site; other site 465817003432 catalytic site [active] 465817003433 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 465817003434 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 465817003435 dimerization interface [polypeptide binding]; other site 465817003436 putative ATP binding site [chemical binding]; other site 465817003437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817003438 active site 465817003439 uracil transporter; Provisional; Region: PRK10720 465817003440 DNA replication initiation factor; Provisional; Region: PRK08084 465817003441 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 465817003442 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 465817003443 ArsC family; Region: ArsC; pfam03960 465817003444 catalytic residues [active] 465817003445 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 465817003446 Peptidase family M48; Region: Peptidase_M48; pfam01435 465817003447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817003448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817003449 metal binding site [ion binding]; metal-binding site 465817003450 active site 465817003451 I-site; other site 465817003452 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 465817003453 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 465817003454 catalytic triad [active] 465817003455 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 465817003456 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 465817003457 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 465817003458 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 465817003459 dihydrodipicolinate synthase; Region: dapA; TIGR00674 465817003460 dimer interface [polypeptide binding]; other site 465817003461 active site 465817003462 catalytic residue [active] 465817003463 lipoprotein; Provisional; Region: PRK11679 465817003464 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 465817003465 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 465817003466 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 465817003467 ATP binding site [chemical binding]; other site 465817003468 active site 465817003469 substrate binding site [chemical binding]; other site 465817003470 Predicted metalloprotease [General function prediction only]; Region: COG2321 465817003471 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 465817003472 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 465817003473 Helicase; Region: Helicase_RecD; pfam05127 465817003474 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 465817003475 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 465817003476 hypothetical protein; Provisional; Region: PRK13664 465817003477 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 465817003478 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 465817003479 metal binding site [ion binding]; metal-binding site 465817003480 dimer interface [polypeptide binding]; other site 465817003481 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 465817003482 ArsC family; Region: ArsC; pfam03960 465817003483 putative catalytic residues [active] 465817003484 Colicin pore forming domain; Region: Colicin; pfam01024 465817003485 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 465817003486 Protein export membrane protein; Region: SecD_SecF; cl14618 465817003487 transcriptional regulator NarP; Provisional; Region: PRK10403 465817003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003489 active site 465817003490 phosphorylation site [posttranslational modification] 465817003491 intermolecular recognition site; other site 465817003492 dimerization interface [polypeptide binding]; other site 465817003493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817003494 DNA binding residues [nucleotide binding] 465817003495 dimerization interface [polypeptide binding]; other site 465817003496 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817003497 L-asparagine permease; Provisional; Region: PRK15049 465817003498 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 465817003499 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 465817003500 dimer interface [polypeptide binding]; other site 465817003501 ADP-ribose binding site [chemical binding]; other site 465817003502 active site 465817003503 nudix motif; other site 465817003504 metal binding site [ion binding]; metal-binding site 465817003505 transketolase; Reviewed; Region: PRK12753 465817003506 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 465817003507 TPP-binding site [chemical binding]; other site 465817003508 dimer interface [polypeptide binding]; other site 465817003509 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 465817003510 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 465817003511 PYR/PP interface [polypeptide binding]; other site 465817003512 dimer interface [polypeptide binding]; other site 465817003513 TPP binding site [chemical binding]; other site 465817003514 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465817003515 transaldolase-like protein; Provisional; Region: PTZ00411 465817003516 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 465817003517 active site 465817003518 dimer interface [polypeptide binding]; other site 465817003519 catalytic residue [active] 465817003520 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 465817003521 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 465817003522 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 465817003523 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 465817003524 active site 465817003525 metal binding site [ion binding]; metal-binding site 465817003526 putative acetyltransferase; Provisional; Region: PRK03624 465817003527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817003528 Coenzyme A binding pocket [chemical binding]; other site 465817003529 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 465817003530 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 465817003531 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 465817003532 thiosulfate transporter subunit; Provisional; Region: PRK10852 465817003533 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 465817003534 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 465817003535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003536 dimer interface [polypeptide binding]; other site 465817003537 conserved gate region; other site 465817003538 putative PBP binding loops; other site 465817003539 ABC-ATPase subunit interface; other site 465817003540 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 465817003541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003542 dimer interface [polypeptide binding]; other site 465817003543 conserved gate region; other site 465817003544 putative PBP binding loops; other site 465817003545 ABC-ATPase subunit interface; other site 465817003546 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 465817003547 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 465817003548 Walker A/P-loop; other site 465817003549 ATP binding site [chemical binding]; other site 465817003550 Q-loop/lid; other site 465817003551 ABC transporter signature motif; other site 465817003552 Walker B; other site 465817003553 D-loop; other site 465817003554 H-loop/switch region; other site 465817003555 TOBE-like domain; Region: TOBE_3; pfam12857 465817003556 cysteine synthase B; Region: cysM; TIGR01138 465817003557 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 465817003558 dimer interface [polypeptide binding]; other site 465817003559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003560 catalytic residue [active] 465817003561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817003562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003563 active site 465817003564 phosphorylation site [posttranslational modification] 465817003565 intermolecular recognition site; other site 465817003566 dimerization interface [polypeptide binding]; other site 465817003567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817003568 DNA binding site [nucleotide binding] 465817003569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817003570 dimerization interface [polypeptide binding]; other site 465817003571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817003572 dimer interface [polypeptide binding]; other site 465817003573 phosphorylation site [posttranslational modification] 465817003574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003575 ATP binding site [chemical binding]; other site 465817003576 Mg2+ binding site [ion binding]; other site 465817003577 G-X-G motif; other site 465817003578 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 465817003579 HPr interaction site; other site 465817003580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 465817003581 active site 465817003582 phosphorylation site [posttranslational modification] 465817003583 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 465817003584 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 465817003585 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 465817003586 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 465817003587 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 465817003588 dimerization domain swap beta strand [polypeptide binding]; other site 465817003589 regulatory protein interface [polypeptide binding]; other site 465817003590 active site 465817003591 regulatory phosphorylation site [posttranslational modification]; other site 465817003592 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 465817003593 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 465817003594 dimer interface [polypeptide binding]; other site 465817003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003596 catalytic residue [active] 465817003597 putative sulfate transport protein CysZ; Validated; Region: PRK04949 465817003598 cell division protein ZipA; Provisional; Region: PRK03427 465817003599 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 465817003600 FtsZ protein binding site [polypeptide binding]; other site 465817003601 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 465817003602 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 465817003603 nucleotide binding pocket [chemical binding]; other site 465817003604 K-X-D-G motif; other site 465817003605 catalytic site [active] 465817003606 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 465817003607 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 465817003608 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 465817003609 Dimer interface [polypeptide binding]; other site 465817003610 BRCT sequence motif; other site 465817003611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 465817003612 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 465817003613 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 465817003614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817003615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817003616 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 465817003617 putative dimerization interface [polypeptide binding]; other site 465817003618 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 465817003619 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 465817003620 active site 465817003621 HIGH motif; other site 465817003622 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 465817003623 active site 465817003624 KMSKS motif; other site 465817003625 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 465817003626 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 465817003627 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 465817003628 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 465817003629 Nucleoside recognition; Region: Gate; pfam07670 465817003630 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 465817003631 manganese transport protein MntH; Reviewed; Region: PRK00701 465817003632 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 465817003633 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817003634 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817003635 active site 465817003636 catalytic tetrad [active] 465817003637 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 465817003638 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 465817003639 dimer interface [polypeptide binding]; other site 465817003640 PYR/PP interface [polypeptide binding]; other site 465817003641 TPP binding site [chemical binding]; other site 465817003642 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817003643 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 465817003644 TPP-binding site [chemical binding]; other site 465817003645 dimer interface [polypeptide binding]; other site 465817003646 glucokinase, proteobacterial type; Region: glk; TIGR00749 465817003647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465817003648 nucleotide binding site [chemical binding]; other site 465817003649 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 465817003650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003651 active site 465817003652 phosphorylation site [posttranslational modification] 465817003653 intermolecular recognition site; other site 465817003654 dimerization interface [polypeptide binding]; other site 465817003655 LytTr DNA-binding domain; Region: LytTR; pfam04397 465817003656 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 465817003657 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 465817003658 Histidine kinase; Region: His_kinase; pfam06580 465817003659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003660 ATP binding site [chemical binding]; other site 465817003661 Mg2+ binding site [ion binding]; other site 465817003662 G-X-G motif; other site 465817003663 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 465817003664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465817003665 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465817003666 aminotransferase; Validated; Region: PRK08175 465817003667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817003668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003669 homodimer interface [polypeptide binding]; other site 465817003670 catalytic residue [active] 465817003671 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465817003672 Ligand Binding Site [chemical binding]; other site 465817003673 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 465817003674 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 465817003675 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 465817003676 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 465817003677 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 465817003678 Mechanosensitive ion channel; Region: MS_channel; pfam00924 465817003679 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 465817003680 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 465817003681 silverDB:etchr01120 465817003682 silverDB:etchr01121 465817003683 silverDB:etchr01122 465817003684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 465817003685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003686 ATP binding site [chemical binding]; other site 465817003687 Mg2+ binding site [ion binding]; other site 465817003688 G-X-G motif; other site 465817003689 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 465817003690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817003691 Coenzyme A binding pocket [chemical binding]; other site 465817003692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003693 active site 465817003694 phosphorylation site [posttranslational modification] 465817003695 intermolecular recognition site; other site 465817003696 DNA topoisomerase I; Provisional; Region: PRK14973 465817003697 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 465817003698 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 465817003699 Walker A/P-loop; other site 465817003700 ATP binding site [chemical binding]; other site 465817003701 Q-loop/lid; other site 465817003702 ABC transporter signature motif; other site 465817003703 Walker B; other site 465817003704 D-loop; other site 465817003705 H-loop/switch region; other site 465817003706 heme exporter protein CcmB; Region: ccmB; TIGR01190 465817003707 heme exporter protein CcmC; Region: ccmC; TIGR01191 465817003708 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 465817003709 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 465817003710 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 465817003711 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465817003712 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 465817003713 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 465817003714 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 465817003715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 465817003716 binding surface 465817003717 TPR motif; other site 465817003718 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 465817003719 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 465817003720 Protein of unknown function (DUF406); Region: DUF406; pfam04175 465817003721 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 465817003722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465817003723 dimer interface [polypeptide binding]; other site 465817003724 active site 465817003725 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 465817003726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465817003727 substrate binding site [chemical binding]; other site 465817003728 oxyanion hole (OAH) forming residues; other site 465817003729 trimer interface [polypeptide binding]; other site 465817003730 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 465817003731 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465817003732 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 465817003733 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465817003734 catalytic core [active] 465817003735 hypothetical protein; Provisional; Region: PRK04946 465817003736 Smr domain; Region: Smr; pfam01713 465817003737 HemK family putative methylases; Region: hemK_fam; TIGR00536 465817003738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817003739 S-adenosylmethionine binding site [chemical binding]; other site 465817003740 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 465817003741 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 465817003742 Tetramer interface [polypeptide binding]; other site 465817003743 active site 465817003744 FMN-binding site [chemical binding]; other site 465817003745 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 465817003746 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 465817003747 hypothetical protein; Provisional; Region: PRK10621 465817003748 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 465817003749 Protein of unknown function, DUF462; Region: DUF462; cl01190 465817003750 YfcL protein; Region: YfcL; pfam08891 465817003751 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 465817003752 Uncharacterized conserved protein [Function unknown]; Region: COG4121 465817003753 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 465817003754 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 465817003755 dimer interface [polypeptide binding]; other site 465817003756 active site 465817003757 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465817003758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817003759 catalytic residue [active] 465817003760 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 465817003761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817003762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003763 homodimer interface [polypeptide binding]; other site 465817003764 catalytic residue [active] 465817003765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817003766 DNA-binding site [nucleotide binding]; DNA binding site 465817003767 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 465817003768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817003769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003770 homodimer interface [polypeptide binding]; other site 465817003771 catalytic residue [active] 465817003772 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 465817003773 active site residue [active] 465817003774 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 465817003775 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 465817003776 EamA-like transporter family; Region: EamA; pfam00892 465817003777 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 465817003778 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 465817003779 ligand binding site [chemical binding]; other site 465817003780 NAD binding site [chemical binding]; other site 465817003781 catalytic site [active] 465817003782 homodimer interface [polypeptide binding]; other site 465817003783 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 465817003784 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 465817003785 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 465817003786 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 465817003787 dimerization interface 3.5A [polypeptide binding]; other site 465817003788 active site 465817003789 hypothetical protein; Provisional; Region: PRK10847 465817003790 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465817003791 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 465817003792 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 465817003793 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 465817003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465817003796 cell division protein DedD; Provisional; Region: PRK11633 465817003797 Sporulation related domain; Region: SPOR; pfam05036 465817003798 colicin V production protein; Provisional; Region: PRK10845 465817003799 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 465817003800 amidophosphoribosyltransferase; Provisional; Region: PRK09246 465817003801 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 465817003802 active site 465817003803 tetramer interface [polypeptide binding]; other site 465817003804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817003805 active site 465817003806 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 465817003807 Flavoprotein; Region: Flavoprotein; pfam02441 465817003808 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 465817003809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817003810 substrate binding pocket [chemical binding]; other site 465817003811 membrane-bound complex binding site; other site 465817003812 hinge residues; other site 465817003813 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817003814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003815 dimer interface [polypeptide binding]; other site 465817003816 conserved gate region; other site 465817003817 putative PBP binding loops; other site 465817003818 ABC-ATPase subunit interface; other site 465817003819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003820 dimer interface [polypeptide binding]; other site 465817003821 conserved gate region; other site 465817003822 putative PBP binding loops; other site 465817003823 ABC-ATPase subunit interface; other site 465817003824 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 465817003825 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817003826 Walker A/P-loop; other site 465817003827 ATP binding site [chemical binding]; other site 465817003828 Q-loop/lid; other site 465817003829 ABC transporter signature motif; other site 465817003830 Walker B; other site 465817003831 D-loop; other site 465817003832 H-loop/switch region; other site 465817003833 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 465817003834 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 465817003835 putative NAD(P) binding site [chemical binding]; other site 465817003836 putative active site [active] 465817003837 glutathione S-transferase; Provisional; Region: PRK15113 465817003838 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 465817003839 C-terminal domain interface [polypeptide binding]; other site 465817003840 GSH binding site (G-site) [chemical binding]; other site 465817003841 dimer interface [polypeptide binding]; other site 465817003842 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 465817003843 N-terminal domain interface [polypeptide binding]; other site 465817003844 putative dimer interface [polypeptide binding]; other site 465817003845 putative substrate binding pocket (H-site) [chemical binding]; other site 465817003846 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 465817003847 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 465817003848 nudix motif; other site 465817003849 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 465817003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 465817003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817003852 dimer interface [polypeptide binding]; other site 465817003853 conserved gate region; other site 465817003854 putative PBP binding loops; other site 465817003855 ABC-ATPase subunit interface; other site 465817003856 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 465817003857 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 465817003858 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 465817003859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817003860 inhibitor-cofactor binding pocket; inhibition site 465817003861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003862 catalytic residue [active] 465817003863 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 465817003864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817003865 DNA-binding site [nucleotide binding]; DNA binding site 465817003866 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817003867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003868 homodimer interface [polypeptide binding]; other site 465817003869 catalytic residue [active] 465817003870 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 465817003871 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 465817003872 Walker A/P-loop; other site 465817003873 ATP binding site [chemical binding]; other site 465817003874 Q-loop/lid; other site 465817003875 ABC transporter signature motif; other site 465817003876 Walker B; other site 465817003877 D-loop; other site 465817003878 H-loop/switch region; other site 465817003879 TOBE domain; Region: TOBE_2; pfam08402 465817003880 phosphate acetyltransferase; Reviewed; Region: PRK05632 465817003881 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465817003882 DRTGG domain; Region: DRTGG; pfam07085 465817003883 phosphate acetyltransferase; Region: pta; TIGR00651 465817003884 propionate/acetate kinase; Provisional; Region: PRK12379 465817003885 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 465817003886 hypothetical protein; Provisional; Region: PRK01816 465817003887 putative phosphatase; Provisional; Region: PRK11587 465817003888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817003889 motif I; other site 465817003890 active site 465817003891 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 465817003892 active site 465817003893 conformational flexibility of ligand binding pocket; other site 465817003894 ADP-ribosylating toxin turn-turn motif; other site 465817003895 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 465817003896 active site 465817003897 conformational flexibility of ligand binding pocket; other site 465817003898 ADP-ribosylating toxin turn-turn motif; other site 465817003899 5'-nucleotidase; Provisional; Region: PRK03826 465817003900 aminotransferase AlaT; Validated; Region: PRK09265 465817003901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817003902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817003903 homodimer interface [polypeptide binding]; other site 465817003904 catalytic residue [active] 465817003905 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 465817003906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817003907 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 465817003908 putative dimerization interface [polypeptide binding]; other site 465817003909 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 465817003910 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 465817003911 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 465817003912 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 465817003913 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 465817003914 NADH dehydrogenase subunit E; Validated; Region: PRK07539 465817003915 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 465817003916 putative dimer interface [polypeptide binding]; other site 465817003917 [2Fe-2S] cluster binding site [ion binding]; other site 465817003918 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 465817003919 SLBB domain; Region: SLBB; pfam10531 465817003920 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 465817003921 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 465817003922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465817003923 catalytic loop [active] 465817003924 iron binding site [ion binding]; other site 465817003925 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 465817003926 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 465817003927 [4Fe-4S] binding site [ion binding]; other site 465817003928 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 465817003929 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 465817003930 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 465817003931 4Fe-4S binding domain; Region: Fer4; pfam00037 465817003932 4Fe-4S binding domain; Region: Fer4; pfam00037 465817003933 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 465817003934 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 465817003935 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 465817003936 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 465817003937 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 465817003938 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465817003939 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 465817003940 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465817003941 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 465817003942 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 465817003943 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 465817003944 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 465817003945 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 465817003946 hypothetical protein; Provisional; Region: PRK10404 465817003947 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 465817003948 potassium uptake protein; Region: kup; TIGR00794 465817003949 hypothetical protein; Provisional; Region: PRK03673 465817003950 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 465817003951 putative MPT binding site; other site 465817003952 Competence-damaged protein; Region: CinA; cl00666 465817003953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465817003954 catalytic loop [active] 465817003955 iron binding site [ion binding]; other site 465817003956 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 465817003957 dimer interface [polypeptide binding]; other site 465817003958 putative radical transfer pathway; other site 465817003959 diiron center [ion binding]; other site 465817003960 tyrosyl radical; other site 465817003961 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 465817003962 ATP cone domain; Region: ATP-cone; pfam03477 465817003963 Class I ribonucleotide reductase; Region: RNR_I; cd01679 465817003964 active site 465817003965 dimer interface [polypeptide binding]; other site 465817003966 catalytic residues [active] 465817003967 effector binding site; other site 465817003968 R2 peptide binding site; other site 465817003969 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 465817003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817003971 S-adenosylmethionine binding site [chemical binding]; other site 465817003972 DNA gyrase subunit A; Validated; Region: PRK05560 465817003973 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 465817003974 CAP-like domain; other site 465817003975 active site 465817003976 primary dimer interface [polypeptide binding]; other site 465817003977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003978 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003979 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003980 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003981 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 465817003983 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 465817003984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817003985 dimer interface [polypeptide binding]; other site 465817003986 phosphorylation site [posttranslational modification] 465817003987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817003988 ATP binding site [chemical binding]; other site 465817003989 Mg2+ binding site [ion binding]; other site 465817003990 G-X-G motif; other site 465817003991 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 465817003992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003993 active site 465817003994 phosphorylation site [posttranslational modification] 465817003995 intermolecular recognition site; other site 465817003996 dimerization interface [polypeptide binding]; other site 465817003997 transcriptional regulator RcsB; Provisional; Region: PRK10840 465817003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817003999 active site 465817004000 phosphorylation site [posttranslational modification] 465817004001 intermolecular recognition site; other site 465817004002 dimerization interface [polypeptide binding]; other site 465817004003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817004004 DNA binding residues [nucleotide binding] 465817004005 dimerization interface [polypeptide binding]; other site 465817004006 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 465817004007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817004008 ATP binding site [chemical binding]; other site 465817004009 Mg2+ binding site [ion binding]; other site 465817004010 G-X-G motif; other site 465817004011 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 465817004012 putative binding surface; other site 465817004013 active site 465817004014 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 465817004015 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 465817004016 trimer interface [polypeptide binding]; other site 465817004017 eyelet of channel; other site 465817004018 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 465817004019 ApbE family; Region: ApbE; pfam02424 465817004020 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 465817004021 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 465817004022 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 465817004023 Walker A/P-loop; other site 465817004024 ATP binding site [chemical binding]; other site 465817004025 Q-loop/lid; other site 465817004026 ABC transporter signature motif; other site 465817004027 Walker B; other site 465817004028 D-loop; other site 465817004029 H-loop/switch region; other site 465817004030 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817004031 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817004032 Walker A/P-loop; other site 465817004033 ATP binding site [chemical binding]; other site 465817004034 Q-loop/lid; other site 465817004035 ABC transporter signature motif; other site 465817004036 Walker B; other site 465817004037 D-loop; other site 465817004038 H-loop/switch region; other site 465817004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817004040 dimer interface [polypeptide binding]; other site 465817004041 conserved gate region; other site 465817004042 putative PBP binding loops; other site 465817004043 ABC-ATPase subunit interface; other site 465817004044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817004045 Coenzyme A binding pocket [chemical binding]; other site 465817004046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465817004047 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817004048 substrate binding pocket [chemical binding]; other site 465817004049 membrane-bound complex binding site; other site 465817004050 hinge residues; other site 465817004051 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 465817004052 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 465817004053 metal binding site [ion binding]; metal-binding site 465817004054 dimer interface [polypeptide binding]; other site 465817004055 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 465817004056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 465817004057 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 465817004058 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 465817004059 active site 465817004060 intersubunit interface [polypeptide binding]; other site 465817004061 catalytic residue [active] 465817004062 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 465817004063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817004064 substrate binding site [chemical binding]; other site 465817004065 ATP binding site [chemical binding]; other site 465817004066 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 465817004067 L-aspartate oxidase; Provisional; Region: PRK06175 465817004068 FAD binding domain; Region: FAD_binding_2; pfam00890 465817004069 L-aspartate oxidase; Provisional; Region: PRK06175 465817004070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817004071 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 465817004072 putative substrate translocation pore; other site 465817004073 choline dehydrogenase; Validated; Region: PRK02106 465817004074 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 465817004075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 465817004076 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 465817004077 NAD(P) binding site [chemical binding]; other site 465817004078 catalytic residues [active] 465817004079 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 465817004080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 465817004081 substrate binding site [chemical binding]; other site 465817004082 oxyanion hole (OAH) forming residues; other site 465817004083 trimer interface [polypeptide binding]; other site 465817004084 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 465817004085 Coenzyme A transferase; Region: CoA_trans; smart00882 465817004086 Coenzyme A transferase; Region: CoA_trans; cl17247 465817004087 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817004088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817004089 DNA binding site [nucleotide binding] 465817004090 domain linker motif; other site 465817004091 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 465817004092 putative dimerization interface [polypeptide binding]; other site 465817004093 putative ligand binding site [chemical binding]; other site 465817004094 silverDB:etchr01245 465817004095 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 465817004096 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 465817004097 putative active site [active] 465817004098 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 465817004099 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 465817004100 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 465817004101 Sulfatase; Region: Sulfatase; cl17466 465817004102 hypothetical protein; Provisional; Region: PRK13689 465817004103 Nucleoid-associated protein [General function prediction only]; Region: COG3081 465817004104 nucleoid-associated protein NdpA; Validated; Region: PRK00378 465817004105 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 465817004106 5S rRNA interface [nucleotide binding]; other site 465817004107 CTC domain interface [polypeptide binding]; other site 465817004108 L16 interface [polypeptide binding]; other site 465817004109 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 465817004110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817004111 ATP binding site [chemical binding]; other site 465817004112 putative Mg++ binding site [ion binding]; other site 465817004113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817004114 nucleotide binding region [chemical binding]; other site 465817004115 ATP-binding site [chemical binding]; other site 465817004116 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 465817004117 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 465817004118 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817004119 RNA binding surface [nucleotide binding]; other site 465817004120 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 465817004121 active site 465817004122 uracil binding [chemical binding]; other site 465817004123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817004124 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 465817004125 putative substrate translocation pore; other site 465817004126 hypothetical protein; Provisional; Region: PRK11835 465817004127 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 465817004128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817004129 Walker A/P-loop; other site 465817004130 ATP binding site [chemical binding]; other site 465817004131 Q-loop/lid; other site 465817004132 ABC transporter signature motif; other site 465817004133 Walker B; other site 465817004134 D-loop; other site 465817004135 H-loop/switch region; other site 465817004136 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817004137 Walker A/P-loop; other site 465817004138 ATP binding site [chemical binding]; other site 465817004139 Q-loop/lid; other site 465817004140 ABC transporter signature motif; other site 465817004141 Walker B; other site 465817004142 D-loop; other site 465817004143 H-loop/switch region; other site 465817004144 microcin C ABC transporter permease; Provisional; Region: PRK15021 465817004145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817004146 dimer interface [polypeptide binding]; other site 465817004147 conserved gate region; other site 465817004148 ABC-ATPase subunit interface; other site 465817004149 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 465817004150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817004151 dimer interface [polypeptide binding]; other site 465817004152 conserved gate region; other site 465817004153 putative PBP binding loops; other site 465817004154 ABC-ATPase subunit interface; other site 465817004155 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 465817004156 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 465817004157 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 465817004158 phage resistance protein; Provisional; Region: PRK10551 465817004159 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 465817004160 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817004161 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 465817004162 NlpC/P60 family; Region: NLPC_P60; pfam00877 465817004163 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 465817004164 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 465817004165 active site 465817004166 elongation factor P; Provisional; Region: PRK04542 465817004167 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 465817004168 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 465817004169 RNA binding site [nucleotide binding]; other site 465817004170 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 465817004171 RNA binding site [nucleotide binding]; other site 465817004172 Flagellin N-methylase; Region: FliB; cl00497 465817004173 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 465817004174 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 465817004175 active site 465817004176 phosphorylation site [posttranslational modification] 465817004177 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 465817004178 dimerization domain swap beta strand [polypeptide binding]; other site 465817004179 regulatory protein interface [polypeptide binding]; other site 465817004180 active site 465817004181 regulatory phosphorylation site [posttranslational modification]; other site 465817004182 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 465817004183 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 465817004184 putative substrate binding site [chemical binding]; other site 465817004185 putative ATP binding site [chemical binding]; other site 465817004186 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 465817004187 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 465817004188 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 465817004189 active site 465817004190 P-loop; other site 465817004191 phosphorylation site [posttranslational modification] 465817004192 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 465817004193 endonuclease IV; Provisional; Region: PRK01060 465817004194 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 465817004195 AP (apurinic/apyrimidinic) site pocket; other site 465817004196 DNA interaction; other site 465817004197 Metal-binding active site; metal-binding site 465817004198 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 465817004199 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 465817004200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817004201 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 465817004202 putative dimerization interface [polypeptide binding]; other site 465817004203 lysine transporter; Provisional; Region: PRK10836 465817004204 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817004205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817004206 ABC-ATPase subunit interface; other site 465817004207 dimer interface [polypeptide binding]; other site 465817004208 putative PBP binding regions; other site 465817004209 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 465817004210 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465817004211 Walker A/P-loop; other site 465817004212 ATP binding site [chemical binding]; other site 465817004213 Q-loop/lid; other site 465817004214 ABC transporter signature motif; other site 465817004215 Walker B; other site 465817004216 D-loop; other site 465817004217 H-loop/switch region; other site 465817004218 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 465817004219 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 465817004220 putative active site [active] 465817004221 putative catalytic triad [active] 465817004222 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 465817004223 aromatic chitin/cellulose binding site residues [chemical binding]; other site 465817004224 S-formylglutathione hydrolase; Region: PLN02442 465817004225 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 465817004226 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 465817004227 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 465817004228 substrate binding site [chemical binding]; other site 465817004229 catalytic Zn binding site [ion binding]; other site 465817004230 NAD binding site [chemical binding]; other site 465817004231 structural Zn binding site [ion binding]; other site 465817004232 dimer interface [polypeptide binding]; other site 465817004233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817004234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817004235 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 465817004236 putative dimerization interface [polypeptide binding]; other site 465817004237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817004238 putative substrate translocation pore; other site 465817004239 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 465817004240 homodecamer interface [polypeptide binding]; other site 465817004241 GTP cyclohydrolase I; Provisional; Region: PLN03044 465817004242 active site 465817004243 putative catalytic site residues [active] 465817004244 zinc binding site [ion binding]; other site 465817004245 GTP-CH-I/GFRP interaction surface; other site 465817004246 Predicted membrane protein [Function unknown]; Region: COG2311 465817004247 hypothetical protein; Provisional; Region: PRK10835 465817004248 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 465817004249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817004250 DNA binding site [nucleotide binding] 465817004251 domain linker motif; other site 465817004252 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 465817004253 dimerization interface (closed form) [polypeptide binding]; other site 465817004254 ligand binding site [chemical binding]; other site 465817004255 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 465817004256 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 465817004257 ligand binding site [chemical binding]; other site 465817004258 calcium binding site [ion binding]; other site 465817004259 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817004260 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 465817004261 Walker A/P-loop; other site 465817004262 ATP binding site [chemical binding]; other site 465817004263 Q-loop/lid; other site 465817004264 ABC transporter signature motif; other site 465817004265 Walker B; other site 465817004266 D-loop; other site 465817004267 H-loop/switch region; other site 465817004268 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817004269 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817004270 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817004271 TM-ABC transporter signature motif; other site 465817004272 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 465817004273 putative active site [active] 465817004274 malate dehydrogenase; Provisional; Region: PRK13529 465817004275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 465817004276 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 465817004277 NAD(P) binding site [chemical binding]; other site 465817004278 cytidine deaminase; Provisional; Region: PRK09027 465817004279 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 465817004280 active site 465817004281 catalytic motif [active] 465817004282 Zn binding site [ion binding]; other site 465817004283 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 465817004284 hypothetical protein; Provisional; Region: PRK10711 465817004285 hypothetical protein; Provisional; Region: PRK01821 465817004286 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 465817004287 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 465817004288 active site 465817004289 HIGH motif; other site 465817004290 KMSKS motif; other site 465817004291 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 465817004292 tRNA binding surface [nucleotide binding]; other site 465817004293 anticodon binding site; other site 465817004294 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 465817004295 dimer interface [polypeptide binding]; other site 465817004296 putative tRNA-binding site [nucleotide binding]; other site 465817004297 antiporter inner membrane protein; Provisional; Region: PRK11670 465817004298 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 465817004299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 465817004300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817004301 Coenzyme A binding pocket [chemical binding]; other site 465817004302 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 465817004303 dimer interface [polypeptide binding]; other site 465817004304 substrate binding site [chemical binding]; other site 465817004305 ATP binding site [chemical binding]; other site 465817004306 lipid kinase; Reviewed; Region: PRK13054 465817004307 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 465817004308 putative protease; Provisional; Region: PRK15452 465817004309 Peptidase family U32; Region: Peptidase_U32; pfam01136 465817004310 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 465817004311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817004312 active site 465817004313 phosphorylation site [posttranslational modification] 465817004314 intermolecular recognition site; other site 465817004315 dimerization interface [polypeptide binding]; other site 465817004316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817004317 DNA binding site [nucleotide binding] 465817004318 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 465817004319 Complementary sex determiner protein; Region: Apis_Csd; pfam11671 465817004320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817004321 dimerization interface [polypeptide binding]; other site 465817004322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817004323 dimer interface [polypeptide binding]; other site 465817004324 phosphorylation site [posttranslational modification] 465817004325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817004326 ATP binding site [chemical binding]; other site 465817004327 Mg2+ binding site [ion binding]; other site 465817004328 G-X-G motif; other site 465817004329 putative transporter; Provisional; Region: PRK10504 465817004330 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 465817004331 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 465817004332 Protein export membrane protein; Region: SecD_SecF; cl14618 465817004333 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 465817004334 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465817004335 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817004336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817004337 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817004338 active site 465817004339 catalytic tetrad [active] 465817004340 putative chaperone; Provisional; Region: PRK11678 465817004341 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 465817004342 nucleotide binding site [chemical binding]; other site 465817004343 putative NEF/HSP70 interaction site [polypeptide binding]; other site 465817004344 SBD interface [polypeptide binding]; other site 465817004345 MASE1; Region: MASE1; cl17823 465817004346 PAS domain S-box; Region: sensory_box; TIGR00229 465817004347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817004348 putative active site [active] 465817004349 heme pocket [chemical binding]; other site 465817004350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817004351 PAS fold; Region: PAS_3; pfam08447 465817004352 putative active site [active] 465817004353 heme pocket [chemical binding]; other site 465817004354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817004355 PAS domain; Region: PAS_9; pfam13426 465817004356 putative active site [active] 465817004357 heme pocket [chemical binding]; other site 465817004358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817004359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817004360 metal binding site [ion binding]; metal-binding site 465817004361 active site 465817004362 I-site; other site 465817004363 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 465817004364 active site 465817004365 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 465817004366 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 465817004367 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 465817004368 ATP-binding site [chemical binding]; other site 465817004369 Sugar specificity; other site 465817004370 Pyrimidine base specificity; other site 465817004371 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 465817004372 trimer interface [polypeptide binding]; other site 465817004373 active site 465817004374 putative assembly protein; Provisional; Region: PRK10833 465817004375 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 465817004376 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 465817004377 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 465817004378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465817004379 Transporter associated domain; Region: CorC_HlyC; smart01091 465817004380 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 465817004381 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 465817004382 Bacterial sugar transferase; Region: Bac_transf; pfam02397 465817004383 polysaccharide export protein Wza; Provisional; Region: PRK15078 465817004384 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 465817004385 SLBB domain; Region: SLBB; pfam10531 465817004386 Low molecular weight phosphatase family; Region: LMWPc; cd00115 465817004387 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 465817004388 active site 465817004389 tyrosine kinase; Provisional; Region: PRK11519 465817004390 Chain length determinant protein; Region: Wzz; pfam02706 465817004391 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 465817004392 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 465817004393 P loop; other site 465817004394 Nucleotide binding site [chemical binding]; other site 465817004395 DTAP/Switch II; other site 465817004396 Switch I; other site 465817004397 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 465817004398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 465817004399 active site 465817004400 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 465817004401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 465817004402 active site 465817004403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465817004404 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 465817004405 putative ADP-binding pocket [chemical binding]; other site 465817004406 Head binding; Region: Head_binding; pfam09008 465817004407 colanic acid biosynthesis protein; Provisional; Region: PRK10017 465817004408 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 465817004409 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 465817004410 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 465817004411 putative ADP-binding pocket [chemical binding]; other site 465817004412 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 465817004413 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 465817004414 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 465817004415 active site 465817004416 tetramer interface; other site 465817004417 UDP-glucose 4-epimerase; Region: PLN02240 465817004418 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 465817004419 NAD binding site [chemical binding]; other site 465817004420 homodimer interface [polypeptide binding]; other site 465817004421 active site 465817004422 substrate binding site [chemical binding]; other site 465817004423 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 465817004424 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 465817004425 NAD binding site [chemical binding]; other site 465817004426 substrate binding site [chemical binding]; other site 465817004427 homodimer interface [polypeptide binding]; other site 465817004428 active site 465817004429 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 465817004430 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 465817004431 substrate binding site; other site 465817004432 tetramer interface; other site 465817004433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817004434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465817004435 NAD(P) binding site [chemical binding]; other site 465817004436 active site 465817004437 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 465817004438 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 465817004439 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 465817004440 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 465817004441 Walker A/P-loop; other site 465817004442 ATP binding site [chemical binding]; other site 465817004443 Q-loop/lid; other site 465817004444 ABC transporter signature motif; other site 465817004445 Walker B; other site 465817004446 D-loop; other site 465817004447 H-loop/switch region; other site 465817004448 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 465817004449 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 465817004450 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 465817004451 Ligand binding site; other site 465817004452 metal-binding site 465817004453 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 465817004454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465817004455 UDP-galactopyranose mutase; Region: GLF; pfam03275 465817004456 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 465817004457 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 465817004458 active site 465817004459 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 465817004460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 465817004461 putative ADP-binding pocket [chemical binding]; other site 465817004462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 465817004463 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 465817004464 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 465817004465 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 465817004466 active site 465817004467 Zn binding site [ion binding]; other site 465817004468 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 465817004469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817004470 substrate binding pocket [chemical binding]; other site 465817004471 membrane-bound complex binding site; other site 465817004472 hinge residues; other site 465817004473 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 465817004474 putative deacylase active site [active] 465817004475 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 465817004476 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 465817004477 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 465817004478 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 465817004479 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 465817004480 substrate binding site [chemical binding]; other site 465817004481 glutamase interaction surface [polypeptide binding]; other site 465817004482 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 465817004483 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 465817004484 catalytic residues [active] 465817004485 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 465817004486 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 465817004487 putative active site [active] 465817004488 oxyanion strand; other site 465817004489 catalytic triad [active] 465817004490 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 465817004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817004492 active site 465817004493 motif I; other site 465817004494 motif II; other site 465817004495 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 465817004496 putative active site pocket [active] 465817004497 4-fold oligomerization interface [polypeptide binding]; other site 465817004498 metal binding residues [ion binding]; metal-binding site 465817004499 3-fold/trimer interface [polypeptide binding]; other site 465817004500 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 465817004501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817004502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817004503 homodimer interface [polypeptide binding]; other site 465817004504 catalytic residue [active] 465817004505 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 465817004506 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 465817004507 NAD binding site [chemical binding]; other site 465817004508 dimerization interface [polypeptide binding]; other site 465817004509 product binding site; other site 465817004510 substrate binding site [chemical binding]; other site 465817004511 zinc binding site [ion binding]; other site 465817004512 catalytic residues [active] 465817004513 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 465817004514 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 465817004515 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 465817004516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465817004517 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 465817004518 putative NAD(P) binding site [chemical binding]; other site 465817004519 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 465817004520 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 465817004521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817004522 catalytic residue [active] 465817004523 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 465817004524 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 465817004525 exonuclease I; Provisional; Region: sbcB; PRK11779 465817004526 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 465817004527 active site 465817004528 catalytic site [active] 465817004529 substrate binding site [chemical binding]; other site 465817004530 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 465817004531 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 465817004532 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 465817004533 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 465817004534 Predicted membrane protein [Function unknown]; Region: COG1289 465817004535 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465817004536 hypothetical protein; Provisional; Region: PRK05423 465817004537 MATE family multidrug exporter; Provisional; Region: PRK10189 465817004538 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 465817004539 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 465817004540 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 465817004541 FAD binding pocket [chemical binding]; other site 465817004542 FAD binding motif [chemical binding]; other site 465817004543 phosphate binding motif [ion binding]; other site 465817004544 NAD binding pocket [chemical binding]; other site 465817004545 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465817004546 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 465817004547 active site 465817004548 FMN binding site [chemical binding]; other site 465817004549 substrate binding site [chemical binding]; other site 465817004550 homotetramer interface [polypeptide binding]; other site 465817004551 catalytic residue [active] 465817004552 Protein of unknown function DUF262; Region: DUF262; pfam03235 465817004553 Uncharacterized conserved protein [Function unknown]; Region: COG1479 465817004554 Protein of unknown function DUF262; Region: DUF262; pfam03235 465817004555 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 465817004556 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 465817004557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817004558 Walker A motif; other site 465817004559 ATP binding site [chemical binding]; other site 465817004560 Walker B motif; other site 465817004561 arginine finger; other site 465817004562 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 465817004563 DNA-binding interface [nucleotide binding]; DNA binding site 465817004564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465817004565 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 465817004566 putative NAD(P) binding site [chemical binding]; other site 465817004567 catalytic Zn binding site [ion binding]; other site 465817004568 AMP nucleosidase; Provisional; Region: PRK08292 465817004569 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 465817004570 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 465817004571 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 465817004572 Cupin; Region: Cupin_1; smart00835 465817004573 Cupin; Region: Cupin_1; smart00835 465817004574 Predicted membrane protein [Function unknown]; Region: COG2323 465817004575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 465817004576 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 465817004577 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 465817004578 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 465817004579 putative ligand binding site [chemical binding]; other site 465817004580 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 465817004581 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817004582 Walker A/P-loop; other site 465817004583 ATP binding site [chemical binding]; other site 465817004584 Q-loop/lid; other site 465817004585 ABC transporter signature motif; other site 465817004586 Walker B; other site 465817004587 D-loop; other site 465817004588 H-loop/switch region; other site 465817004589 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817004590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817004591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817004592 TM-ABC transporter signature motif; other site 465817004593 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 465817004594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817004595 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 465817004596 putative dimerization interface [polypeptide binding]; other site 465817004597 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 465817004598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817004599 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 465817004600 substrate binding site [chemical binding]; other site 465817004601 dimerization interface [polypeptide binding]; other site 465817004602 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817004603 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 465817004604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817004605 Coenzyme A binding pocket [chemical binding]; other site 465817004606 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 465817004607 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 465817004608 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 465817004609 substrate binding site; other site 465817004610 Manganese binding site; other site 465817004611 dimer interface; other site 465817004612 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 465817004613 FAD binding domain; Region: FAD_binding_4; pfam01565 465817004614 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 465817004615 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 465817004616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817004617 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817004618 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 465817004619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465817004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 465817004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817004622 ABC-ATPase subunit interface; other site 465817004623 putative PBP binding loops; other site 465817004624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 465817004625 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 465817004626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817004627 Walker A/P-loop; other site 465817004628 ATP binding site [chemical binding]; other site 465817004629 Q-loop/lid; other site 465817004630 ABC transporter signature motif; other site 465817004631 Walker B; other site 465817004632 D-loop; other site 465817004633 H-loop/switch region; other site 465817004634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465817004635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817004636 Walker A/P-loop; other site 465817004637 ATP binding site [chemical binding]; other site 465817004638 Q-loop/lid; other site 465817004639 ABC transporter signature motif; other site 465817004640 Walker B; other site 465817004641 D-loop; other site 465817004642 H-loop/switch region; other site 465817004643 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 465817004644 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 465817004645 intersubunit interface [polypeptide binding]; other site 465817004646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817004647 non-specific DNA binding site [nucleotide binding]; other site 465817004648 salt bridge; other site 465817004649 sequence-specific DNA binding site [nucleotide binding]; other site 465817004650 hypothetical protein; Provisional; Region: PRK06185 465817004651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465817004652 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 465817004653 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 465817004654 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 465817004655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817004656 DNA-binding site [nucleotide binding]; DNA binding site 465817004657 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 465817004658 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 465817004659 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 465817004660 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 465817004661 active site turn [active] 465817004662 phosphorylation site [posttranslational modification] 465817004663 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 465817004664 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 465817004665 NAD binding site [chemical binding]; other site 465817004666 sugar binding site [chemical binding]; other site 465817004667 divalent metal binding site [ion binding]; other site 465817004668 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 465817004669 dimer interface [polypeptide binding]; other site 465817004670 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 465817004671 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817004672 P-loop; other site 465817004673 Magnesium ion binding site [ion binding]; other site 465817004674 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817004675 Magnesium ion binding site [ion binding]; other site 465817004676 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 465817004677 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817004678 ABC-ATPase subunit interface; other site 465817004679 dimer interface [polypeptide binding]; other site 465817004680 putative PBP binding regions; other site 465817004681 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 465817004682 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817004683 ABC-ATPase subunit interface; other site 465817004684 dimer interface [polypeptide binding]; other site 465817004685 putative PBP binding regions; other site 465817004686 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 465817004687 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 465817004688 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 465817004689 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 465817004690 metal binding site [ion binding]; metal-binding site 465817004691 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 465817004692 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 465817004693 heme binding site [chemical binding]; other site 465817004694 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 465817004695 heme binding site [chemical binding]; other site 465817004696 Nuclease-related domain; Region: NERD; pfam08378 465817004697 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 465817004698 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 465817004699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 465817004700 Zn2+ binding site [ion binding]; other site 465817004701 Mg2+ binding site [ion binding]; other site 465817004702 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 465817004703 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817004704 dimer interface [polypeptide binding]; other site 465817004705 ligand binding site [chemical binding]; other site 465817004706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817004707 dimer interface [polypeptide binding]; other site 465817004708 putative CheW interface [polypeptide binding]; other site 465817004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 465817004710 DNA cytosine methylase; Provisional; Region: PRK10458 465817004711 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 465817004712 cofactor binding site; other site 465817004713 DNA binding site [nucleotide binding] 465817004714 substrate interaction site [chemical binding]; other site 465817004715 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 465817004716 additional DNA contacts [nucleotide binding]; other site 465817004717 mismatch recognition site; other site 465817004718 active site 465817004719 zinc binding site [ion binding]; other site 465817004720 DNA intercalation site [nucleotide binding]; other site 465817004721 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 465817004722 EamA-like transporter family; Region: EamA; pfam00892 465817004723 hypothetical protein; Provisional; Region: PRK10062 465817004724 lipoprotein; Provisional; Region: PRK10397 465817004725 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 465817004726 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 465817004727 active site 465817004728 Na/Ca binding site [ion binding]; other site 465817004729 catalytic site [active] 465817004730 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 465817004731 flagellar protein FliS; Validated; Region: fliS; PRK05685 465817004732 flagellar capping protein; Reviewed; Region: fliD; PRK08032 465817004733 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 465817004734 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 465817004735 flagellin; Provisional; Region: PRK12802 465817004736 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 465817004737 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 465817004738 HNH endonuclease; Region: HNH_2; pfam13391 465817004739 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 465817004740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817004741 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 465817004742 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817004743 DNA binding residues [nucleotide binding] 465817004744 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 465817004745 D-cysteine desulfhydrase; Validated; Region: PRK03910 465817004746 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 465817004747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817004748 catalytic residue [active] 465817004749 Predicted membrane protein [Function unknown]; Region: COG4763 465817004750 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817004751 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 465817004752 Predicted transcriptional regulator [Transcription]; Region: COG3905 465817004753 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 465817004754 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 465817004755 Glutamate binding site [chemical binding]; other site 465817004756 NAD binding site [chemical binding]; other site 465817004757 catalytic residues [active] 465817004758 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 465817004759 Na binding site [ion binding]; other site 465817004760 FTR1 family protein; Region: TIGR00145 465817004761 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 465817004762 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 465817004763 Imelysin; Region: Peptidase_M75; pfam09375 465817004764 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 465817004765 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 465817004766 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 465817004767 hypothetical protein; Provisional; Region: PRK10536 465817004768 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 465817004769 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 465817004770 dimer interface [polypeptide binding]; other site 465817004771 FMN binding site [chemical binding]; other site 465817004772 NADPH bind site [chemical binding]; other site 465817004773 Predicted membrane protein [Function unknown]; Region: COG4763 465817004774 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817004775 alkaline phosphatase; Provisional; Region: PRK10518 465817004776 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 465817004777 dimer interface [polypeptide binding]; other site 465817004778 active site 465817004779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817004780 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 465817004781 POT family; Region: PTR2; cl17359 465817004782 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 465817004783 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 465817004784 putative ligand binding site [chemical binding]; other site 465817004785 NAD binding site [chemical binding]; other site 465817004786 dimerization interface [polypeptide binding]; other site 465817004787 catalytic site [active] 465817004788 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 465817004789 CcdB protein; Region: CcdB; cl03380 465817004790 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 465817004791 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 465817004792 EamA-like transporter family; Region: EamA; pfam00892 465817004793 EamA-like transporter family; Region: EamA; pfam00892 465817004794 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 465817004795 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 465817004796 Na binding site [ion binding]; other site 465817004797 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 465817004798 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 465817004799 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 465817004800 Predicted flavoprotein [General function prediction only]; Region: COG0431 465817004801 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 465817004802 dimer interface [polypeptide binding]; other site 465817004803 active site 465817004804 Schiff base residues; other site 465817004805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817004806 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 465817004807 Walker A motif; other site 465817004808 ATP binding site [chemical binding]; other site 465817004809 Walker B motif; other site 465817004810 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 465817004811 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 465817004812 active site 465817004813 DNA binding site [nucleotide binding] 465817004814 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 465817004815 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 465817004816 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 465817004817 Catalytic site [active] 465817004818 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 465817004819 hydrophobic ligand binding site; other site 465817004820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817004821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817004822 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 465817004823 putative substrate binding pocket [chemical binding]; other site 465817004824 putative dimerization interface [polypeptide binding]; other site 465817004825 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 465817004826 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 465817004827 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 465817004828 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 465817004829 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 465817004830 active site 465817004831 homotetramer interface [polypeptide binding]; other site 465817004832 transcriptional activator FlhD; Provisional; Region: PRK02909 465817004833 transcriptional activator FlhC; Provisional; Region: PRK12722 465817004834 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 465817004835 flagellar motor protein MotA; Validated; Region: PRK09110 465817004836 flagellar motor protein MotB; Validated; Region: motB; PRK09041 465817004837 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 465817004838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 465817004839 ligand binding site [chemical binding]; other site 465817004840 chemotaxis protein CheA; Provisional; Region: PRK10547 465817004841 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 465817004842 putative binding surface; other site 465817004843 active site 465817004844 CheY binding; Region: CheY-binding; pfam09078 465817004845 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 465817004846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817004847 ATP binding site [chemical binding]; other site 465817004848 Mg2+ binding site [ion binding]; other site 465817004849 G-X-G motif; other site 465817004850 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 465817004851 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 465817004852 putative CheA interaction surface; other site 465817004853 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 465817004854 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817004855 dimer interface [polypeptide binding]; other site 465817004856 ligand binding site [chemical binding]; other site 465817004857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817004858 dimerization interface [polypeptide binding]; other site 465817004859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817004860 dimer interface [polypeptide binding]; other site 465817004861 putative CheW interface [polypeptide binding]; other site 465817004862 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 465817004863 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817004864 dimer interface [polypeptide binding]; other site 465817004865 ligand binding site [chemical binding]; other site 465817004866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817004867 dimerization interface [polypeptide binding]; other site 465817004868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817004869 dimer interface [polypeptide binding]; other site 465817004870 putative CheW interface [polypeptide binding]; other site 465817004871 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 465817004872 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817004873 dimer interface [polypeptide binding]; other site 465817004874 ligand binding site [chemical binding]; other site 465817004875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817004876 dimerization interface [polypeptide binding]; other site 465817004877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817004878 dimer interface [polypeptide binding]; other site 465817004879 putative CheW interface [polypeptide binding]; other site 465817004880 methyl-accepting protein IV; Provisional; Region: PRK09793 465817004881 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817004882 dimer interface [polypeptide binding]; other site 465817004883 ligand binding site [chemical binding]; other site 465817004884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817004885 dimerization interface [polypeptide binding]; other site 465817004886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817004887 dimer interface [polypeptide binding]; other site 465817004888 putative CheW interface [polypeptide binding]; other site 465817004889 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 465817004890 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 465817004891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817004892 S-adenosylmethionine binding site [chemical binding]; other site 465817004893 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 465817004894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817004895 active site 465817004896 phosphorylation site [posttranslational modification] 465817004897 intermolecular recognition site; other site 465817004898 dimerization interface [polypeptide binding]; other site 465817004899 CheB methylesterase; Region: CheB_methylest; pfam01339 465817004900 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 465817004901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817004902 active site 465817004903 phosphorylation site [posttranslational modification] 465817004904 intermolecular recognition site; other site 465817004905 dimerization interface [polypeptide binding]; other site 465817004906 chemotaxis regulator CheZ; Provisional; Region: PRK11166 465817004907 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 465817004908 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 465817004909 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 465817004910 FHIPEP family; Region: FHIPEP; pfam00771 465817004911 Flagellar protein FlhE; Region: FlhE; pfam06366 465817004912 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 465817004913 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 465817004914 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 465817004915 active site 465817004916 HIGH motif; other site 465817004917 KMSK motif region; other site 465817004918 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 465817004919 tRNA binding surface [nucleotide binding]; other site 465817004920 anticodon binding site; other site 465817004921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 465817004922 putative metal binding site [ion binding]; other site 465817004923 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 465817004924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817004925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817004926 homodimer interface [polypeptide binding]; other site 465817004927 catalytic residue [active] 465817004928 copper homeostasis protein CutC; Provisional; Region: PRK11572 465817004929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 465817004930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817004931 S-adenosylmethionine binding site [chemical binding]; other site 465817004932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817004933 S-adenosylmethionine binding site [chemical binding]; other site 465817004934 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 465817004935 hypothetical protein; Provisional; Region: PRK10302 465817004936 Isochorismatase family; Region: Isochorismatase; pfam00857 465817004937 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 465817004938 catalytic triad [active] 465817004939 conserved cis-peptide bond; other site 465817004940 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 465817004941 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 465817004942 dimer interface [polypeptide binding]; other site 465817004943 anticodon binding site; other site 465817004944 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 465817004945 homodimer interface [polypeptide binding]; other site 465817004946 motif 1; other site 465817004947 active site 465817004948 motif 2; other site 465817004949 GAD domain; Region: GAD; pfam02938 465817004950 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465817004951 active site 465817004952 motif 3; other site 465817004953 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 465817004954 nudix motif; other site 465817004955 hypothetical protein; Validated; Region: PRK00110 465817004956 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 465817004957 active site 465817004958 putative DNA-binding cleft [nucleotide binding]; other site 465817004959 dimer interface [polypeptide binding]; other site 465817004960 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 465817004961 RuvA N terminal domain; Region: RuvA_N; pfam01330 465817004962 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 465817004963 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 465817004964 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 465817004965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817004966 Walker A motif; other site 465817004967 ATP binding site [chemical binding]; other site 465817004968 Walker B motif; other site 465817004969 arginine finger; other site 465817004970 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 465817004971 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 465817004972 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817004973 ABC-ATPase subunit interface; other site 465817004974 dimer interface [polypeptide binding]; other site 465817004975 putative PBP binding regions; other site 465817004976 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 465817004977 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 465817004978 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 465817004979 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 465817004980 metal binding site [ion binding]; metal-binding site 465817004981 putative peptidase; Provisional; Region: PRK11649 465817004982 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 465817004983 Peptidase family M23; Region: Peptidase_M23; pfam01551 465817004984 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 465817004985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 465817004986 putative acyl-acceptor binding pocket; other site 465817004987 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 465817004988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817004989 putative substrate translocation pore; other site 465817004990 pyruvate kinase; Provisional; Region: PRK05826 465817004991 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 465817004992 domain interfaces; other site 465817004993 active site 465817004994 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 465817004995 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 465817004996 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 465817004997 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 465817004998 ATP-grasp domain; Region: ATP-grasp; pfam02222 465817004999 YebG protein; Region: YebG; pfam07130 465817005000 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 465817005001 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 465817005002 Metal-binding active site; metal-binding site 465817005003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 465817005004 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 465817005005 putative metal binding site [ion binding]; other site 465817005006 protease 2; Provisional; Region: PRK10115 465817005007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465817005008 exodeoxyribonuclease X; Provisional; Region: PRK07983 465817005009 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 465817005010 active site 465817005011 catalytic site [active] 465817005012 substrate binding site [chemical binding]; other site 465817005013 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 465817005014 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 465817005015 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 465817005016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465817005017 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 465817005018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817005019 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 465817005020 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 465817005021 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 465817005022 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 465817005023 mce related protein; Region: MCE; pfam02470 465817005024 mce related protein; Region: MCE; pfam02470 465817005025 mce related protein; Region: MCE; pfam02470 465817005026 mce related protein; Region: MCE; pfam02470 465817005027 mce related protein; Region: MCE; pfam02470 465817005028 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 465817005029 Paraquat-inducible protein A; Region: PqiA; pfam04403 465817005030 Paraquat-inducible protein A; Region: PqiA; pfam04403 465817005031 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 465817005032 GAF domain; Region: GAF_2; pfam13185 465817005033 ProP expression regulator; Provisional; Region: PRK04950 465817005034 ProQ/FINO family; Region: ProQ; pfam04352 465817005035 putative RNA binding sites [nucleotide binding]; other site 465817005036 carboxy-terminal protease; Provisional; Region: PRK11186 465817005037 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 465817005038 protein binding site [polypeptide binding]; other site 465817005039 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 465817005040 Catalytic dyad [active] 465817005041 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 465817005042 heat shock protein HtpX; Provisional; Region: PRK05457 465817005043 YobH-like protein; Region: YobH; pfam13996 465817005044 YebO-like protein; Region: YebO; pfam13974 465817005045 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 465817005046 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 465817005047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465817005048 DNA-binding site [nucleotide binding]; DNA binding site 465817005049 RNA-binding motif; other site 465817005050 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 465817005051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817005052 S-adenosylmethionine binding site [chemical binding]; other site 465817005053 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 465817005054 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 465817005055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465817005056 Transporter associated domain; Region: CorC_HlyC; smart01091 465817005057 L-serine deaminase; Provisional; Region: PRK15023 465817005058 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 465817005059 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 465817005060 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 465817005061 putative active site [active] 465817005062 putative CoA binding site [chemical binding]; other site 465817005063 nudix motif; other site 465817005064 metal binding site [ion binding]; metal-binding site 465817005065 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 465817005066 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 465817005067 chorismate binding enzyme; Region: Chorismate_bind; cl10555 465817005068 hypothetical protein; Provisional; Region: PRK05114 465817005069 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 465817005070 homotrimer interaction site [polypeptide binding]; other site 465817005071 putative active site [active] 465817005072 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 465817005073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 465817005074 ATP binding site [chemical binding]; other site 465817005075 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 465817005076 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 465817005077 Glycoprotease family; Region: Peptidase_M22; pfam00814 465817005078 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 465817005079 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 465817005080 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 465817005081 acyl-activating enzyme (AAE) consensus motif; other site 465817005082 putative AMP binding site [chemical binding]; other site 465817005083 putative active site [active] 465817005084 putative CoA binding site [chemical binding]; other site 465817005085 ribonuclease D; Provisional; Region: PRK10829 465817005086 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 465817005087 catalytic site [active] 465817005088 putative active site [active] 465817005089 putative substrate binding site [chemical binding]; other site 465817005090 HRDC domain; Region: HRDC; cl02578 465817005091 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 465817005092 cell division inhibitor MinD; Provisional; Region: PRK10818 465817005093 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 465817005094 Switch I; other site 465817005095 Switch II; other site 465817005096 septum formation inhibitor; Reviewed; Region: minC; PRK03511 465817005097 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 465817005098 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 465817005099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 465817005100 hypothetical protein; Provisional; Region: PRK10691 465817005101 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 465817005102 hypothetical protein; Provisional; Region: PRK05170 465817005103 disulfide bond formation protein B; Provisional; Region: PRK01749 465817005104 fatty acid metabolism regulator; Provisional; Region: PRK04984 465817005105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817005106 DNA-binding site [nucleotide binding]; DNA binding site 465817005107 FadR C-terminal domain; Region: FadR_C; pfam07840 465817005108 SpoVR family protein; Provisional; Region: PRK11767 465817005109 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 465817005110 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 465817005111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817005112 hydroxyglutarate oxidase; Provisional; Region: PRK11728 465817005113 alanine racemase; Reviewed; Region: dadX; PRK03646 465817005114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 465817005115 active site 465817005116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465817005117 substrate binding site [chemical binding]; other site 465817005118 catalytic residues [active] 465817005119 dimer interface [polypeptide binding]; other site 465817005120 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 465817005121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005122 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 465817005123 Bacterial sugar transferase; Region: Bac_transf; pfam02397 465817005124 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 465817005125 TrkA-C domain; Region: TrkA_C; pfam02080 465817005126 Transporter associated domain; Region: CorC_HlyC; smart01091 465817005127 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 465817005128 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 465817005129 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 465817005130 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 465817005131 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 465817005132 short chain dehydrogenase; Provisional; Region: PRK06180 465817005133 NADP binding site [chemical binding]; other site 465817005134 active site 465817005135 steroid binding site; other site 465817005136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817005137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005138 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 465817005139 putative effector binding pocket; other site 465817005140 putative dimerization interface [polypeptide binding]; other site 465817005141 hypothetical protein; Provisional; Region: PRK05325 465817005142 PrkA family serine protein kinase; Provisional; Region: PRK15455 465817005143 AAA ATPase domain; Region: AAA_16; pfam13191 465817005144 Walker A motif; other site 465817005145 ATP binding site [chemical binding]; other site 465817005146 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 465817005147 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 465817005148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817005149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817005150 active site 465817005151 catalytic tetrad [active] 465817005152 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 465817005153 active site 465817005154 phosphate binding residues; other site 465817005155 catalytic residues [active] 465817005156 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 465817005157 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 465817005158 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 465817005159 methionine sulfoxide reductase B; Provisional; Region: PRK00222 465817005160 SelR domain; Region: SelR; pfam01641 465817005161 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 465817005162 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 465817005163 Isochorismatase family; Region: Isochorismatase; pfam00857 465817005164 catalytic triad [active] 465817005165 metal binding site [ion binding]; metal-binding site 465817005166 conserved cis-peptide bond; other site 465817005167 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 465817005168 active site 465817005169 homodimer interface [polypeptide binding]; other site 465817005170 protease 4; Provisional; Region: PRK10949 465817005171 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 465817005172 tandem repeat interface [polypeptide binding]; other site 465817005173 oligomer interface [polypeptide binding]; other site 465817005174 active site residues [active] 465817005175 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 465817005176 tandem repeat interface [polypeptide binding]; other site 465817005177 oligomer interface [polypeptide binding]; other site 465817005178 active site residues [active] 465817005179 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 465817005180 putative FMN binding site [chemical binding]; other site 465817005181 DNA topoisomerase III; Provisional; Region: PRK07726 465817005182 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 465817005183 active site 465817005184 putative interdomain interaction site [polypeptide binding]; other site 465817005185 putative metal-binding site [ion binding]; other site 465817005186 putative nucleotide binding site [chemical binding]; other site 465817005187 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 465817005188 domain I; other site 465817005189 DNA binding groove [nucleotide binding] 465817005190 phosphate binding site [ion binding]; other site 465817005191 domain II; other site 465817005192 domain III; other site 465817005193 nucleotide binding site [chemical binding]; other site 465817005194 catalytic site [active] 465817005195 domain IV; other site 465817005196 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 465817005197 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 465817005198 putative catalytic site [active] 465817005199 putative phosphate binding site [ion binding]; other site 465817005200 active site 465817005201 metal binding site A [ion binding]; metal-binding site 465817005202 DNA binding site [nucleotide binding] 465817005203 putative AP binding site [nucleotide binding]; other site 465817005204 putative metal binding site B [ion binding]; other site 465817005205 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 465817005206 substrate binding pocket [chemical binding]; other site 465817005207 active site 465817005208 hypothetical protein; Provisional; Region: PRK10621 465817005209 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 465817005210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 465817005211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465817005212 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 465817005213 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 465817005214 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 465817005215 putative active site [active] 465817005216 putative substrate binding site [chemical binding]; other site 465817005217 putative cosubstrate binding site; other site 465817005218 catalytic site [active] 465817005219 SEC-C motif; Region: SEC-C; pfam02810 465817005220 hypothetical protein; Provisional; Region: PRK04233 465817005221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817005222 active site 465817005223 response regulator of RpoS; Provisional; Region: PRK10693 465817005224 phosphorylation site [posttranslational modification] 465817005225 intermolecular recognition site; other site 465817005226 dimerization interface [polypeptide binding]; other site 465817005227 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 465817005228 active site 465817005229 tetramer interface; other site 465817005230 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 465817005231 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 465817005232 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 465817005233 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 465817005234 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 465817005235 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 465817005236 putative NAD(P) binding site [chemical binding]; other site 465817005237 active site 465817005238 putative substrate binding site [chemical binding]; other site 465817005239 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 465817005240 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 465817005241 thymidine kinase; Provisional; Region: PRK04296 465817005242 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 465817005243 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 465817005244 putative catalytic cysteine [active] 465817005245 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 465817005246 putative active site [active] 465817005247 metal binding site [ion binding]; metal-binding site 465817005248 hypothetical protein; Provisional; Region: PRK11111 465817005249 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 465817005250 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 465817005251 peptide binding site [polypeptide binding]; other site 465817005252 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 465817005253 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 465817005254 peptide binding site [polypeptide binding]; other site 465817005255 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 465817005256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817005257 dimer interface [polypeptide binding]; other site 465817005258 conserved gate region; other site 465817005259 putative PBP binding loops; other site 465817005260 ABC-ATPase subunit interface; other site 465817005261 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 465817005262 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 465817005263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817005264 dimer interface [polypeptide binding]; other site 465817005265 conserved gate region; other site 465817005266 ABC-ATPase subunit interface; other site 465817005267 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 465817005268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817005269 Walker A/P-loop; other site 465817005270 ATP binding site [chemical binding]; other site 465817005271 Q-loop/lid; other site 465817005272 ABC transporter signature motif; other site 465817005273 Walker B; other site 465817005274 D-loop; other site 465817005275 H-loop/switch region; other site 465817005276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465817005277 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 465817005278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817005279 Walker A/P-loop; other site 465817005280 ATP binding site [chemical binding]; other site 465817005281 Q-loop/lid; other site 465817005282 ABC transporter signature motif; other site 465817005283 Walker B; other site 465817005284 D-loop; other site 465817005285 H-loop/switch region; other site 465817005286 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 465817005287 dsDNA-mimic protein; Reviewed; Region: PRK05094 465817005288 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 465817005289 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 465817005290 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 465817005291 putative active site [active] 465817005292 catalytic site [active] 465817005293 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 465817005294 putative active site [active] 465817005295 catalytic site [active] 465817005296 YciI-like protein; Reviewed; Region: PRK11370 465817005297 transport protein TonB; Provisional; Region: PRK10819 465817005298 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 465817005299 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 465817005300 intracellular septation protein A; Reviewed; Region: PRK00259 465817005301 hypothetical protein; Provisional; Region: PRK02868 465817005302 outer membrane protein W; Provisional; Region: PRK10959 465817005303 BON domain; Region: BON; pfam04972 465817005304 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 465817005305 substrate binding site [chemical binding]; other site 465817005306 active site 465817005307 catalytic residues [active] 465817005308 heterodimer interface [polypeptide binding]; other site 465817005309 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 465817005310 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 465817005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817005312 catalytic residue [active] 465817005313 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 465817005314 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 465817005315 active site 465817005316 ribulose/triose binding site [chemical binding]; other site 465817005317 phosphate binding site [ion binding]; other site 465817005318 substrate (anthranilate) binding pocket [chemical binding]; other site 465817005319 product (indole) binding pocket [chemical binding]; other site 465817005320 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 465817005321 active site 465817005322 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 465817005323 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 465817005324 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 465817005325 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 465817005326 Glutamine amidotransferase class-I; Region: GATase; pfam00117 465817005327 glutamine binding [chemical binding]; other site 465817005328 catalytic triad [active] 465817005329 anthranilate synthase component I; Provisional; Region: PRK13564 465817005330 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 465817005331 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 465817005332 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 465817005333 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 465817005334 active site 465817005335 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 465817005336 hypothetical protein; Provisional; Region: PRK11630 465817005337 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 465817005338 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 465817005339 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 465817005340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817005341 RNA binding surface [nucleotide binding]; other site 465817005342 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 465817005343 probable active site [active] 465817005344 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 465817005345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817005346 NAD(P) binding site [chemical binding]; other site 465817005347 active site 465817005348 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 465817005349 putative inner membrane peptidase; Provisional; Region: PRK11778 465817005350 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 465817005351 tandem repeat interface [polypeptide binding]; other site 465817005352 oligomer interface [polypeptide binding]; other site 465817005353 active site residues [active] 465817005354 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 465817005355 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 465817005356 active site 465817005357 interdomain interaction site; other site 465817005358 putative metal-binding site [ion binding]; other site 465817005359 nucleotide binding site [chemical binding]; other site 465817005360 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 465817005361 domain I; other site 465817005362 DNA binding groove [nucleotide binding] 465817005363 phosphate binding site [ion binding]; other site 465817005364 domain II; other site 465817005365 domain III; other site 465817005366 nucleotide binding site [chemical binding]; other site 465817005367 catalytic site [active] 465817005368 domain IV; other site 465817005369 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 465817005370 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 465817005371 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 465817005372 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 465817005373 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 465817005374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005375 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 465817005376 substrate binding site [chemical binding]; other site 465817005377 putative dimerization interface [polypeptide binding]; other site 465817005378 aconitate hydratase; Validated; Region: PRK09277 465817005379 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 465817005380 substrate binding site [chemical binding]; other site 465817005381 ligand binding site [chemical binding]; other site 465817005382 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 465817005383 substrate binding site [chemical binding]; other site 465817005384 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 465817005385 dimerization interface [polypeptide binding]; other site 465817005386 active site 465817005387 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 465817005388 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 465817005389 active site 465817005390 Predicted membrane protein [Function unknown]; Region: COG3771 465817005391 tetratricopeptide repeat protein; Provisional; Region: PRK11788 465817005392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 465817005393 binding surface 465817005394 TPR motif; other site 465817005395 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 465817005396 active site 465817005397 dimer interface [polypeptide binding]; other site 465817005398 translation initiation factor Sui1; Validated; Region: PRK06824 465817005399 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 465817005400 putative rRNA binding site [nucleotide binding]; other site 465817005401 lipoprotein; Provisional; Region: PRK10540 465817005402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 465817005403 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 465817005404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817005405 catalytic residue [active] 465817005406 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 465817005407 homotrimer interaction site [polypeptide binding]; other site 465817005408 putative active site [active] 465817005409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 465817005410 YheO-like PAS domain; Region: PAS_6; pfam08348 465817005411 HTH domain; Region: HTH_22; pfam13309 465817005412 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 465817005413 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 465817005414 intersubunit interface [polypeptide binding]; other site 465817005415 active site 465817005416 Zn2+ binding site [ion binding]; other site 465817005417 exoribonuclease II; Provisional; Region: PRK05054 465817005418 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 465817005419 RNB domain; Region: RNB; pfam00773 465817005420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465817005421 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 465817005422 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 465817005423 putative molybdopterin cofactor binding site [chemical binding]; other site 465817005424 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 465817005425 putative molybdopterin cofactor binding site; other site 465817005426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817005427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 465817005429 dimerization interface [polypeptide binding]; other site 465817005430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 465817005431 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 465817005432 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 465817005433 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 465817005434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817005435 Walker A/P-loop; other site 465817005436 ATP binding site [chemical binding]; other site 465817005437 Q-loop/lid; other site 465817005438 ABC transporter signature motif; other site 465817005439 Walker B; other site 465817005440 D-loop; other site 465817005441 H-loop/switch region; other site 465817005442 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 465817005443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817005444 Walker A/P-loop; other site 465817005445 ATP binding site [chemical binding]; other site 465817005446 Q-loop/lid; other site 465817005447 ABC transporter signature motif; other site 465817005448 Walker B; other site 465817005449 D-loop; other site 465817005450 H-loop/switch region; other site 465817005451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465817005452 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 465817005453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817005454 dimer interface [polypeptide binding]; other site 465817005455 conserved gate region; other site 465817005456 putative PBP binding loops; other site 465817005457 ABC-ATPase subunit interface; other site 465817005458 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 465817005459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817005460 dimer interface [polypeptide binding]; other site 465817005461 conserved gate region; other site 465817005462 putative PBP binding loops; other site 465817005463 ABC-ATPase subunit interface; other site 465817005464 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 465817005465 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 465817005466 peptide binding site [polypeptide binding]; other site 465817005467 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 465817005468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817005469 Walker A motif; other site 465817005470 ATP binding site [chemical binding]; other site 465817005471 Walker B motif; other site 465817005472 arginine finger; other site 465817005473 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 465817005474 phage shock protein PspA; Provisional; Region: PRK10698 465817005475 phage shock protein B; Provisional; Region: pspB; PRK09458 465817005476 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 465817005477 phage shock protein C; Region: phageshock_pspC; TIGR02978 465817005478 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 465817005479 Predicted ATPase [General function prediction only]; Region: COG3106 465817005480 hypothetical protein; Provisional; Region: PRK05415 465817005481 Domain of unknown function (DUF697); Region: DUF697; cl12064 465817005482 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 465817005483 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 465817005484 putative aromatic amino acid binding site; other site 465817005485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817005486 putative active site [active] 465817005487 heme pocket [chemical binding]; other site 465817005488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817005489 Walker A motif; other site 465817005490 ATP binding site [chemical binding]; other site 465817005491 Walker B motif; other site 465817005492 arginine finger; other site 465817005493 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 465817005494 dimer interface [polypeptide binding]; other site 465817005495 catalytic triad [active] 465817005496 peroxidatic and resolving cysteines [active] 465817005497 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 465817005498 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 465817005499 active site 465817005500 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 465817005501 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 465817005502 peptide binding site [polypeptide binding]; other site 465817005503 hypothetical protein; Provisional; Region: PRK15301 465817005504 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 465817005505 PapC N-terminal domain; Region: PapC_N; pfam13954 465817005506 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817005507 PapC C-terminal domain; Region: PapC_C; pfam13953 465817005508 putative fimbrial chaperone protein; Provisional; Region: PRK09918 465817005509 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817005510 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817005511 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 465817005512 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 465817005513 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 465817005514 Cl binding site [ion binding]; other site 465817005515 oligomer interface [polypeptide binding]; other site 465817005516 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 465817005517 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 465817005518 Ca binding site [ion binding]; other site 465817005519 active site 465817005520 catalytic site [active] 465817005521 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 465817005522 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 465817005523 Ligand Binding Site [chemical binding]; other site 465817005524 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 465817005525 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465817005526 ATP binding site [chemical binding]; other site 465817005527 Mg++ binding site [ion binding]; other site 465817005528 motif III; other site 465817005529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817005530 nucleotide binding region [chemical binding]; other site 465817005531 ATP-binding site [chemical binding]; other site 465817005532 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 465817005533 putative RNA binding site [nucleotide binding]; other site 465817005534 Uncharacterized conserved protein [Function unknown]; Region: COG1359 465817005535 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 465817005536 Domain of unknown function (DUF333); Region: DUF333; pfam03891 465817005537 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 465817005538 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 465817005539 putative ligand binding site [chemical binding]; other site 465817005540 putative NAD binding site [chemical binding]; other site 465817005541 catalytic site [active] 465817005542 hypothetical protein; Provisional; Region: PRK10695 465817005543 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 465817005544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 465817005545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 465817005546 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 465817005547 putative ligand binding site [chemical binding]; other site 465817005548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817005549 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817005550 TM-ABC transporter signature motif; other site 465817005551 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 465817005552 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817005553 Walker A/P-loop; other site 465817005554 ATP binding site [chemical binding]; other site 465817005555 Q-loop/lid; other site 465817005556 ABC transporter signature motif; other site 465817005557 Walker B; other site 465817005558 D-loop; other site 465817005559 H-loop/switch region; other site 465817005560 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817005561 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 465817005562 N- and C-terminal domain interface [polypeptide binding]; other site 465817005563 D-xylulose kinase; Region: XylB; TIGR01312 465817005564 active site 465817005565 MgATP binding site [chemical binding]; other site 465817005566 catalytic site [active] 465817005567 metal binding site [ion binding]; metal-binding site 465817005568 xylulose binding site [chemical binding]; other site 465817005569 putative homodimer interface [polypeptide binding]; other site 465817005570 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465817005571 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 465817005572 inhibitor binding site; inhibition site 465817005573 catalytic Zn binding site [ion binding]; other site 465817005574 structural Zn binding site [ion binding]; other site 465817005575 NADP binding site [chemical binding]; other site 465817005576 tetramer interface [polypeptide binding]; other site 465817005577 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 465817005578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817005579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817005580 DNA binding site [nucleotide binding] 465817005581 domain linker motif; other site 465817005582 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 465817005583 dimerization interface [polypeptide binding]; other site 465817005584 ligand binding site [chemical binding]; other site 465817005585 azoreductase; Reviewed; Region: PRK00170 465817005586 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 465817005587 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 465817005588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817005589 ATP binding site [chemical binding]; other site 465817005590 putative Mg++ binding site [ion binding]; other site 465817005591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817005592 nucleotide binding region [chemical binding]; other site 465817005593 ATP-binding site [chemical binding]; other site 465817005594 Helicase associated domain (HA2); Region: HA2; pfam04408 465817005595 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 465817005596 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 465817005597 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 465817005598 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 465817005599 amidase catalytic site [active] 465817005600 Zn binding residues [ion binding]; other site 465817005601 substrate binding site [chemical binding]; other site 465817005602 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 465817005603 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 465817005604 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 465817005605 active site 465817005606 Zn binding site [ion binding]; other site 465817005607 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 465817005608 sensor protein RstB; Provisional; Region: PRK10604 465817005609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817005610 dimerization interface [polypeptide binding]; other site 465817005611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817005612 dimer interface [polypeptide binding]; other site 465817005613 phosphorylation site [posttranslational modification] 465817005614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817005615 ATP binding site [chemical binding]; other site 465817005616 Mg2+ binding site [ion binding]; other site 465817005617 G-X-G motif; other site 465817005618 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 465817005619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817005620 active site 465817005621 phosphorylation site [posttranslational modification] 465817005622 intermolecular recognition site; other site 465817005623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817005624 DNA binding site [nucleotide binding] 465817005625 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 465817005626 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817005627 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817005628 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 465817005629 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 465817005630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817005631 N-terminal plug; other site 465817005632 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 465817005633 ligand-binding site [chemical binding]; other site 465817005634 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 465817005635 universal stress protein UspE; Provisional; Region: PRK11175 465817005636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465817005637 Ligand Binding Site [chemical binding]; other site 465817005638 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465817005639 Ligand Binding Site [chemical binding]; other site 465817005640 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 465817005641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465817005642 ligand binding site [chemical binding]; other site 465817005643 flexible hinge region; other site 465817005644 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 465817005645 putative switch regulator; other site 465817005646 non-specific DNA interactions [nucleotide binding]; other site 465817005647 DNA binding site [nucleotide binding] 465817005648 sequence specific DNA binding site [nucleotide binding]; other site 465817005649 putative cAMP binding site [chemical binding]; other site 465817005650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 465817005651 Smr domain; Region: Smr; pfam01713 465817005652 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 465817005653 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817005654 benzoate transport; Region: 2A0115; TIGR00895 465817005655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005656 putative substrate translocation pore; other site 465817005657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005658 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 465817005659 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 465817005660 substrate binding pocket [chemical binding]; other site 465817005661 catalytic triad [active] 465817005662 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 465817005663 HAMP domain; Region: HAMP; pfam00672 465817005664 dimerization interface [polypeptide binding]; other site 465817005665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817005666 dimer interface [polypeptide binding]; other site 465817005667 putative CheW interface [polypeptide binding]; other site 465817005668 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 465817005669 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 465817005670 metal binding site [ion binding]; metal-binding site 465817005671 dimer interface [polypeptide binding]; other site 465817005672 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817005673 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 465817005674 peptide binding site [polypeptide binding]; other site 465817005675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817005676 Coenzyme A binding pocket [chemical binding]; other site 465817005677 putative arabinose transporter; Provisional; Region: PRK03545 465817005678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005679 putative substrate translocation pore; other site 465817005680 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 465817005681 glutaminase; Provisional; Region: PRK00971 465817005682 Transcriptional regulator; Region: Rrf2; pfam02082 465817005683 Predicted transcriptional regulator [Transcription]; Region: COG1959 465817005684 silverDB:etchr01690 465817005685 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 465817005686 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465817005687 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 465817005688 active site 465817005689 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 465817005690 RNAase interaction site [polypeptide binding]; other site 465817005691 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 465817005692 Virulence factor SrfB; Region: SrfB; pfam07520 465817005693 malate:quinone oxidoreductase; Validated; Region: PRK05257 465817005694 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 465817005695 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 465817005696 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 465817005697 active site clefts [active] 465817005698 zinc binding site [ion binding]; other site 465817005699 dimer interface [polypeptide binding]; other site 465817005700 HNH endonuclease; Region: HNH_2; pfam13391 465817005701 silverDB:etchr01703 465817005702 silverDB:etchr01704 465817005703 silverDB:etchr01705 465817005704 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 465817005705 active site 465817005706 SAM binding site [chemical binding]; other site 465817005707 homodimer interface [polypeptide binding]; other site 465817005708 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 465817005709 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 465817005710 [4Fe-4S] binding site [ion binding]; other site 465817005711 molybdopterin cofactor binding site; other site 465817005712 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 465817005713 molybdopterin cofactor binding site; other site 465817005714 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 465817005715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 465817005716 nitrite reductase subunit NirD; Provisional; Region: PRK14989 465817005717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817005718 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 465817005719 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 465817005720 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 465817005721 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 465817005722 Walker A/P-loop; other site 465817005723 ATP binding site [chemical binding]; other site 465817005724 Q-loop/lid; other site 465817005725 ABC transporter signature motif; other site 465817005726 Walker B; other site 465817005727 D-loop; other site 465817005728 H-loop/switch region; other site 465817005729 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 465817005730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817005731 dimer interface [polypeptide binding]; other site 465817005732 conserved gate region; other site 465817005733 putative PBP binding loops; other site 465817005734 ABC-ATPase subunit interface; other site 465817005735 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 465817005736 NMT1-like family; Region: NMT1_2; pfam13379 465817005737 Nitrate and nitrite sensing; Region: NIT; pfam08376 465817005738 ANTAR domain; Region: ANTAR; pfam03861 465817005739 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 465817005740 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 465817005741 tetramer interface [polypeptide binding]; other site 465817005742 heme binding pocket [chemical binding]; other site 465817005743 NADPH binding site [chemical binding]; other site 465817005744 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 465817005745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 465817005746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817005747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465817005748 Coenzyme A binding pocket [chemical binding]; other site 465817005749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 465817005750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817005751 Coenzyme A binding pocket [chemical binding]; other site 465817005752 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 465817005753 NADH(P)-binding; Region: NAD_binding_10; pfam13460 465817005754 NAD(P) binding site [chemical binding]; other site 465817005755 putative active site [active] 465817005756 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 465817005757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817005758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817005759 homodimer interface [polypeptide binding]; other site 465817005760 catalytic residue [active] 465817005761 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 465817005762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817005763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 465817005765 putative effector binding pocket; other site 465817005766 putative dimerization interface [polypeptide binding]; other site 465817005767 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 465817005768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465817005769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817005770 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 465817005771 Rdx family; Region: Rdx; cl01407 465817005772 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 465817005773 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817005774 N-terminal plug; other site 465817005775 ligand-binding site [chemical binding]; other site 465817005776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817005777 AAA domain; Region: AAA_23; pfam13476 465817005778 Walker A/P-loop; other site 465817005779 ATP binding site [chemical binding]; other site 465817005780 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 465817005781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817005782 Coenzyme A binding pocket [chemical binding]; other site 465817005783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465817005784 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 465817005785 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 465817005786 active site 465817005787 non-prolyl cis peptide bond; other site 465817005788 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 465817005789 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 465817005790 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 465817005791 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 465817005792 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 465817005793 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 465817005794 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 465817005795 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 465817005796 NAD(P) binding site [chemical binding]; other site 465817005797 Predicted membrane protein [Function unknown]; Region: COG2707 465817005798 hypothetical protein; Provisional; Region: PRK07236 465817005799 salicylate hydroxylase; Provisional; Region: PRK08163 465817005800 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 465817005801 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 465817005802 active site 465817005803 Zn binding site [ion binding]; other site 465817005804 guanine deaminase; Provisional; Region: PRK09228 465817005805 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 465817005806 active site 465817005807 malonic semialdehyde reductase; Provisional; Region: PRK10538 465817005808 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 465817005809 putative NAD(P) binding site [chemical binding]; other site 465817005810 homodimer interface [polypeptide binding]; other site 465817005811 homotetramer interface [polypeptide binding]; other site 465817005812 active site 465817005813 hypothetical protein; Provisional; Region: PRK13659 465817005814 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 465817005815 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 465817005816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005817 putative substrate translocation pore; other site 465817005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005819 putative substrate translocation pore; other site 465817005820 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 465817005821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817005822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005823 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817005824 putative effector binding pocket; other site 465817005825 dimerization interface [polypeptide binding]; other site 465817005826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 465817005827 AAA domain; Region: AAA_26; pfam13500 465817005828 MarR family; Region: MarR_2; cl17246 465817005829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 465817005830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465817005831 nucleotide binding site [chemical binding]; other site 465817005832 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 465817005833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005834 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 465817005835 dimerization interface [polypeptide binding]; other site 465817005836 substrate binding pocket [chemical binding]; other site 465817005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465817005839 putative substrate translocation pore; other site 465817005840 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 465817005841 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 465817005842 fumarate hydratase; Reviewed; Region: fumC; PRK00485 465817005843 Class II fumarases; Region: Fumarase_classII; cd01362 465817005844 active site 465817005845 tetramer interface [polypeptide binding]; other site 465817005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 465817005847 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 465817005848 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 465817005849 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 465817005850 active site 465817005851 purine riboside binding site [chemical binding]; other site 465817005852 putative oxidoreductase; Provisional; Region: PRK11579 465817005853 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 465817005854 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 465817005855 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 465817005856 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 465817005857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817005858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817005859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817005860 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817005861 TM-ABC transporter signature motif; other site 465817005862 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 465817005863 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817005864 Walker A/P-loop; other site 465817005865 ATP binding site [chemical binding]; other site 465817005866 Q-loop/lid; other site 465817005867 ABC transporter signature motif; other site 465817005868 Walker B; other site 465817005869 D-loop; other site 465817005870 H-loop/switch region; other site 465817005871 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817005872 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 465817005873 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 465817005874 ligand binding site [chemical binding]; other site 465817005875 ribulokinase; Provisional; Region: PRK04123 465817005876 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 465817005877 N- and C-terminal domain interface [polypeptide binding]; other site 465817005878 active site 465817005879 MgATP binding site [chemical binding]; other site 465817005880 catalytic site [active] 465817005881 metal binding site [ion binding]; metal-binding site 465817005882 carbohydrate binding site [chemical binding]; other site 465817005883 homodimer interface [polypeptide binding]; other site 465817005884 L-arabinose isomerase; Provisional; Region: PRK02929 465817005885 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 465817005886 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 465817005887 trimer interface [polypeptide binding]; other site 465817005888 putative substrate binding site [chemical binding]; other site 465817005889 putative metal binding site [ion binding]; other site 465817005890 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 465817005891 electron transport complex protein RsxA; Provisional; Region: PRK05151 465817005892 electron transport complex protein RnfB; Provisional; Region: PRK05113 465817005893 Putative Fe-S cluster; Region: FeS; cl17515 465817005894 4Fe-4S binding domain; Region: Fer4; pfam00037 465817005895 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 465817005896 SLBB domain; Region: SLBB; pfam10531 465817005897 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 465817005898 electron transport complex protein RnfG; Validated; Region: PRK01908 465817005899 electron transport complex RsxE subunit; Provisional; Region: PRK12405 465817005900 endonuclease III; Provisional; Region: PRK10702 465817005901 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 465817005902 minor groove reading motif; other site 465817005903 helix-hairpin-helix signature motif; other site 465817005904 substrate binding pocket [chemical binding]; other site 465817005905 active site 465817005906 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 465817005907 choline dehydrogenase; Validated; Region: PRK02106 465817005908 lycopene cyclase; Region: lycopene_cycl; TIGR01789 465817005909 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 465817005910 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 465817005911 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 465817005912 tetrameric interface [polypeptide binding]; other site 465817005913 NAD binding site [chemical binding]; other site 465817005914 catalytic residues [active] 465817005915 transcriptional regulator BetI; Validated; Region: PRK00767 465817005916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817005917 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 465817005918 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 465817005919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817005920 putative substrate translocation pore; other site 465817005921 POT family; Region: PTR2; pfam00854 465817005922 glutathionine S-transferase; Provisional; Region: PRK10542 465817005923 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 465817005924 C-terminal domain interface [polypeptide binding]; other site 465817005925 GSH binding site (G-site) [chemical binding]; other site 465817005926 dimer interface [polypeptide binding]; other site 465817005927 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 465817005928 dimer interface [polypeptide binding]; other site 465817005929 N-terminal domain interface [polypeptide binding]; other site 465817005930 substrate binding pocket (H-site) [chemical binding]; other site 465817005931 pyridoxamine kinase; Validated; Region: PRK05756 465817005932 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 465817005933 dimer interface [polypeptide binding]; other site 465817005934 pyridoxal binding site [chemical binding]; other site 465817005935 ATP binding site [chemical binding]; other site 465817005936 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 465817005937 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 465817005938 active site 465817005939 HIGH motif; other site 465817005940 dimer interface [polypeptide binding]; other site 465817005941 KMSKS motif; other site 465817005942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817005943 RNA binding surface [nucleotide binding]; other site 465817005944 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 465817005945 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 465817005946 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 465817005947 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 465817005948 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 465817005949 transcriptional regulator SlyA; Provisional; Region: PRK03573 465817005950 MarR family; Region: MarR; pfam01047 465817005951 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 465817005952 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817005953 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817005954 Fusaric acid resistance protein family; Region: FUSC; pfam04632 465817005955 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465817005956 Predicted Fe-S protein [General function prediction only]; Region: COG3313 465817005957 transcriptional regulator; Provisional; Region: PRK10632 465817005958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817005959 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817005960 putative effector binding pocket; other site 465817005961 dimerization interface [polypeptide binding]; other site 465817005962 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 465817005963 NADH(P)-binding; Region: NAD_binding_10; pfam13460 465817005964 NAD binding site [chemical binding]; other site 465817005965 substrate binding site [chemical binding]; other site 465817005966 putative active site [active] 465817005967 putative metal dependent hydrolase; Provisional; Region: PRK11598 465817005968 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 465817005969 Sulfatase; Region: Sulfatase; pfam00884 465817005970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465817005971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817005972 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465817005973 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 465817005974 FMN binding site [chemical binding]; other site 465817005975 active site 465817005976 substrate binding site [chemical binding]; other site 465817005977 catalytic residue [active] 465817005978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 465817005979 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 465817005980 dimer interface [polypeptide binding]; other site 465817005981 active site 465817005982 metal binding site [ion binding]; metal-binding site 465817005983 glutathione binding site [chemical binding]; other site 465817005984 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 465817005985 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 465817005986 dimer interface [polypeptide binding]; other site 465817005987 catalytic site [active] 465817005988 putative active site [active] 465817005989 putative substrate binding site [chemical binding]; other site 465817005990 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 465817005991 putative GSH binding site [chemical binding]; other site 465817005992 catalytic residues [active] 465817005993 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 465817005994 NlpC/P60 family; Region: NLPC_P60; pfam00877 465817005995 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 465817005996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817005997 DNA binding site [nucleotide binding] 465817005998 domain linker motif; other site 465817005999 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 465817006000 dimerization interface [polypeptide binding]; other site 465817006001 ligand binding site [chemical binding]; other site 465817006002 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 465817006003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817006004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817006005 dimerization interface [polypeptide binding]; other site 465817006006 putative transporter; Provisional; Region: PRK11043 465817006007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006008 putative substrate translocation pore; other site 465817006009 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 465817006010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817006011 S-adenosylmethionine binding site [chemical binding]; other site 465817006012 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 465817006013 Lumazine binding domain; Region: Lum_binding; pfam00677 465817006014 Lumazine binding domain; Region: Lum_binding; pfam00677 465817006015 silverDB:etchr01800 465817006016 silverDB:etchr01801 465817006017 pyruvate kinase; Provisional; Region: PRK09206 465817006018 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 465817006019 domain interfaces; other site 465817006020 active site 465817006021 murein lipoprotein; Provisional; Region: PRK15396 465817006022 cysteine desufuration protein SufE; Provisional; Region: PRK09296 465817006023 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 465817006024 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 465817006025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817006026 catalytic residue [active] 465817006027 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 465817006028 FeS assembly protein SufD; Region: sufD; TIGR01981 465817006029 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 465817006030 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 465817006031 Walker A/P-loop; other site 465817006032 ATP binding site [chemical binding]; other site 465817006033 Q-loop/lid; other site 465817006034 ABC transporter signature motif; other site 465817006035 Walker B; other site 465817006036 D-loop; other site 465817006037 H-loop/switch region; other site 465817006038 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 465817006039 putative ABC transporter; Region: ycf24; CHL00085 465817006040 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 465817006041 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 465817006042 FAD binding domain; Region: FAD_binding_4; pfam01565 465817006043 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 465817006044 putative inner membrane protein; Provisional; Region: PRK10983 465817006045 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465817006046 phosphoenolpyruvate synthase; Validated; Region: PRK06464 465817006047 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 465817006048 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 465817006049 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 465817006050 PEP synthetase regulatory protein; Provisional; Region: PRK05339 465817006051 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 465817006052 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 465817006053 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 465817006054 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 465817006055 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 465817006056 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 465817006057 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 465817006058 intersubunit interface [polypeptide binding]; other site 465817006059 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817006060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817006061 ABC-ATPase subunit interface; other site 465817006062 dimer interface [polypeptide binding]; other site 465817006063 putative PBP binding regions; other site 465817006064 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 465817006065 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465817006066 Walker A/P-loop; other site 465817006067 ATP binding site [chemical binding]; other site 465817006068 Q-loop/lid; other site 465817006069 ABC transporter signature motif; other site 465817006070 Walker B; other site 465817006071 D-loop; other site 465817006072 H-loop/switch region; other site 465817006073 Uncharacterized conserved protein [Function unknown]; Region: COG0397 465817006074 hypothetical protein; Validated; Region: PRK00029 465817006075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 465817006076 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 465817006077 type IV secretion system lipoprotein VirB7; Provisional; Region: PRK13859 465817006078 NlpC/P60 family; Region: NLPC_P60; pfam00877 465817006079 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 465817006080 catalytic residues [active] 465817006081 dimer interface [polypeptide binding]; other site 465817006082 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 465817006083 IHF dimer interface [polypeptide binding]; other site 465817006084 IHF - DNA interface [nucleotide binding]; other site 465817006085 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 465817006086 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 465817006087 putative tRNA-binding site [nucleotide binding]; other site 465817006088 B3/4 domain; Region: B3_4; pfam03483 465817006089 tRNA synthetase B5 domain; Region: B5; smart00874 465817006090 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 465817006091 dimer interface [polypeptide binding]; other site 465817006092 motif 1; other site 465817006093 motif 3; other site 465817006094 motif 2; other site 465817006095 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 465817006096 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 465817006097 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 465817006098 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 465817006099 dimer interface [polypeptide binding]; other site 465817006100 motif 1; other site 465817006101 active site 465817006102 motif 2; other site 465817006103 motif 3; other site 465817006104 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 465817006105 23S rRNA binding site [nucleotide binding]; other site 465817006106 L21 binding site [polypeptide binding]; other site 465817006107 L13 binding site [polypeptide binding]; other site 465817006108 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 465817006109 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 465817006110 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 465817006111 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 465817006112 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 465817006113 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 465817006114 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 465817006115 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 465817006116 active site 465817006117 dimer interface [polypeptide binding]; other site 465817006118 motif 1; other site 465817006119 motif 2; other site 465817006120 motif 3; other site 465817006121 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 465817006122 anticodon binding site; other site 465817006123 Protein of unknown function, DUF481; Region: DUF481; cl01213 465817006124 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 465817006125 Phosphotransferase enzyme family; Region: APH; pfam01636 465817006126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 465817006127 active site 465817006128 ATP binding site [chemical binding]; other site 465817006129 YniB-like protein; Region: YniB; pfam14002 465817006130 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 465817006131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817006132 motif II; other site 465817006133 inner membrane protein; Provisional; Region: PRK11648 465817006134 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465817006135 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 465817006136 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 465817006137 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 465817006138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006139 putative substrate translocation pore; other site 465817006140 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 465817006141 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 465817006142 homodimer interface [polypeptide binding]; other site 465817006143 NAD binding pocket [chemical binding]; other site 465817006144 ATP binding pocket [chemical binding]; other site 465817006145 Mg binding site [ion binding]; other site 465817006146 active-site loop [active] 465817006147 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 465817006148 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 465817006149 GIY-YIG motif/motif A; other site 465817006150 active site 465817006151 catalytic site [active] 465817006152 putative DNA binding site [nucleotide binding]; other site 465817006153 metal binding site [ion binding]; metal-binding site 465817006154 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 465817006155 dimer interface [polypeptide binding]; other site 465817006156 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 465817006157 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 465817006158 putative active site [active] 465817006159 Zn binding site [ion binding]; other site 465817006160 succinylarginine dihydrolase; Provisional; Region: PRK13281 465817006161 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 465817006162 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 465817006163 NAD(P) binding site [chemical binding]; other site 465817006164 catalytic residues [active] 465817006165 arginine succinyltransferase; Provisional; Region: PRK10456 465817006166 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 465817006167 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 465817006168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817006169 inhibitor-cofactor binding pocket; inhibition site 465817006170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817006171 catalytic residue [active] 465817006172 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 465817006173 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 465817006174 trimer interface [polypeptide binding]; other site 465817006175 eyelet of channel; other site 465817006176 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 465817006177 putative invasin; Provisional; Region: PRK10177 465817006178 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 465817006179 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 465817006180 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 465817006181 ligand binding site [chemical binding]; other site 465817006182 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 465817006183 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 465817006184 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 465817006185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817006186 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 465817006187 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 465817006188 putative active site pocket [active] 465817006189 dimerization interface [polypeptide binding]; other site 465817006190 putative catalytic residue [active] 465817006191 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817006192 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 465817006193 putative ATP binding site [chemical binding]; other site 465817006194 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 465817006195 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 465817006196 trimer interface; other site 465817006197 sugar binding site [chemical binding]; other site 465817006198 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 465817006199 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 465817006200 active site turn [active] 465817006201 phosphorylation site [posttranslational modification] 465817006202 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 465817006203 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 465817006204 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 465817006205 substrate binding [chemical binding]; other site 465817006206 active site 465817006207 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 465817006208 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 465817006209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817006210 DNA binding site [nucleotide binding] 465817006211 domain linker motif; other site 465817006212 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 465817006213 dimerization interface [polypeptide binding]; other site 465817006214 ligand binding site [chemical binding]; other site 465817006215 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 465817006216 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 465817006217 META domain; Region: META; cl01245 465817006218 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 465817006219 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 465817006220 hypothetical protein; Provisional; Region: PRK10941 465817006221 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 465817006222 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 465817006223 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 465817006224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817006225 S-adenosylmethionine binding site [chemical binding]; other site 465817006226 peptide chain release factor 1; Validated; Region: prfA; PRK00591 465817006227 This domain is found in peptide chain release factors; Region: PCRF; smart00937 465817006228 RF-1 domain; Region: RF-1; pfam00472 465817006229 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 465817006230 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 465817006231 tRNA; other site 465817006232 putative tRNA binding site [nucleotide binding]; other site 465817006233 putative NADP binding site [chemical binding]; other site 465817006234 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 465817006235 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 465817006236 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 465817006237 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 465817006238 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 465817006239 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 465817006240 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 465817006241 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 465817006242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817006243 active site 465817006244 hypothetical protein; Provisional; Region: PRK10692 465817006245 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 465817006246 putative active site [active] 465817006247 catalytic residue [active] 465817006248 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 465817006249 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 465817006250 Sulfate transporter family; Region: Sulfate_transp; pfam00916 465817006251 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 465817006252 GTP-binding protein YchF; Reviewed; Region: PRK09601 465817006253 YchF GTPase; Region: YchF; cd01900 465817006254 G1 box; other site 465817006255 GTP/Mg2+ binding site [chemical binding]; other site 465817006256 Switch I region; other site 465817006257 G2 box; other site 465817006258 Switch II region; other site 465817006259 G3 box; other site 465817006260 G4 box; other site 465817006261 G5 box; other site 465817006262 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 465817006263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006264 oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882 465817006265 putative substrate translocation pore; other site 465817006266 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 465817006267 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 465817006268 substrate binding [chemical binding]; other site 465817006269 active site 465817006270 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 465817006271 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817006272 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817006273 DNA binding site [nucleotide binding] 465817006274 domain linker motif; other site 465817006275 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 465817006276 putative ligand binding site [chemical binding]; other site 465817006277 putative dimerization interface [polypeptide binding]; other site 465817006278 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 465817006279 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 465817006280 chaperone protein SicA; Provisional; Region: PRK15331 465817006281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 465817006282 binding surface 465817006283 TPR motif; other site 465817006284 type III secretion system protein SpaS; Validated; Region: PRK08156 465817006285 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 465817006286 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 465817006287 type III secretion system protein SpaO; Validated; Region: PRK08158 465817006288 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 465817006289 ATP synthase SpaL; Validated; Region: PRK08149 465817006290 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817006291 Walker A motif; other site 465817006292 ATP binding site [chemical binding]; other site 465817006293 Walker B motif; other site 465817006294 Invasion protein B family; Region: Invas_SpaK; cl04129 465817006295 type III secretion system protein InvA; Provisional; Region: PRK15337 465817006296 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 465817006297 HrpJ-like domain; Region: HrpJ; cl15454 465817006298 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 465817006299 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817006300 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 465817006301 transcriptional regulator InvF; Provisional; Region: PRK15340 465817006302 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 465817006303 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 465817006304 Type III secretion needle MxiH like; Region: MxiH; cl09641 465817006305 silverDB:etchr01901 465817006306 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 465817006307 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 465817006308 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 465817006309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817006310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817006311 DNA binding site [nucleotide binding] 465817006312 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 465817006313 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 465817006314 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 465817006315 sensory histidine kinase DcuS; Provisional; Region: PRK11086 465817006316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817006317 ATP binding site [chemical binding]; other site 465817006318 Mg2+ binding site [ion binding]; other site 465817006319 G-X-G motif; other site 465817006320 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 465817006321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817006322 active site 465817006323 phosphorylation site [posttranslational modification] 465817006324 intermolecular recognition site; other site 465817006325 dimerization interface [polypeptide binding]; other site 465817006326 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 465817006327 ApbE family; Region: ApbE; pfam02424 465817006328 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465817006329 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 465817006330 putative active site [active] 465817006331 putative FMN binding site [chemical binding]; other site 465817006332 putative substrate binding site [chemical binding]; other site 465817006333 putative catalytic residue [active] 465817006334 FMN-binding domain; Region: FMN_bind; cl01081 465817006335 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 465817006336 L-aspartate oxidase; Provisional; Region: PRK06175 465817006337 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 465817006338 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 465817006339 transmembrane helices; other site 465817006340 fumarate hydratase; Provisional; Region: PRK15389 465817006341 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 465817006342 Fumarase C-terminus; Region: Fumerase_C; pfam05683 465817006343 silverDB:etchr01918 465817006344 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 465817006345 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 465817006346 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 465817006347 Trehalase; Region: Trehalase; cl17346 465817006348 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 465817006349 Flagellar regulator YcgR; Region: YcgR; pfam07317 465817006350 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 465817006351 PilZ domain; Region: PilZ; pfam07238 465817006352 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 465817006353 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817006354 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817006355 catalytic residue [active] 465817006356 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 465817006357 dimer interface [polypeptide binding]; other site 465817006358 catalytic triad [active] 465817006359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 465817006360 DinI-like family; Region: DinI; cl11630 465817006361 Protein of unknown function (DUF754); Region: DUF754; pfam05449 465817006362 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 465817006363 Predicted membrane protein [Function unknown]; Region: COG2246 465817006364 GtrA-like protein; Region: GtrA; pfam04138 465817006365 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 465817006366 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 465817006367 Ligand binding site; other site 465817006368 Putative Catalytic site; other site 465817006369 DXD motif; other site 465817006370 isocitrate dehydrogenase; Validated; Region: PRK07362 465817006371 isocitrate dehydrogenase; Reviewed; Region: PRK07006 465817006372 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 465817006373 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 465817006374 active site 465817006375 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 465817006376 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 465817006377 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 465817006378 silverDB:etchr01941 465817006379 silverDB:etchr01942 465817006380 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 465817006381 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 465817006382 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 465817006383 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 465817006384 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 465817006385 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 465817006386 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 465817006387 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 465817006388 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 465817006389 nudix motif; other site 465817006390 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 465817006391 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 465817006392 putative lysogenization regulator; Reviewed; Region: PRK00218 465817006393 adenylosuccinate lyase; Provisional; Region: PRK09285 465817006394 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 465817006395 tetramer interface [polypeptide binding]; other site 465817006396 active site 465817006397 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 465817006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817006399 active site 465817006400 phosphorylation site [posttranslational modification] 465817006401 intermolecular recognition site; other site 465817006402 dimerization interface [polypeptide binding]; other site 465817006403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817006404 DNA binding site [nucleotide binding] 465817006405 sensor protein PhoQ; Provisional; Region: PRK10815 465817006406 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 465817006407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817006408 dimer interface [polypeptide binding]; other site 465817006409 phosphorylation site [posttranslational modification] 465817006410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817006411 ATP binding site [chemical binding]; other site 465817006412 Mg2+ binding site [ion binding]; other site 465817006413 G-X-G motif; other site 465817006414 Uncharacterized conserved protein [Function unknown]; Region: COG2850 465817006415 Cupin-like domain; Region: Cupin_8; pfam13621 465817006416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465817006417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817006418 non-specific DNA binding site [nucleotide binding]; other site 465817006419 salt bridge; other site 465817006420 sequence-specific DNA binding site [nucleotide binding]; other site 465817006421 Cupin domain; Region: Cupin_2; pfam07883 465817006422 benzoate transporter; Region: benE; TIGR00843 465817006423 Benzoate membrane transport protein; Region: BenE; pfam03594 465817006424 NAD-dependent deacetylase; Provisional; Region: PRK00481 465817006425 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 465817006426 NAD+ binding site [chemical binding]; other site 465817006427 substrate binding site [chemical binding]; other site 465817006428 Zn binding site [ion binding]; other site 465817006429 fructokinase; Reviewed; Region: PRK09557 465817006430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465817006431 nucleotide binding site [chemical binding]; other site 465817006432 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 465817006433 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 465817006434 FtsX-like permease family; Region: FtsX; pfam02687 465817006435 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 465817006436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465817006437 Walker A/P-loop; other site 465817006438 ATP binding site [chemical binding]; other site 465817006439 Q-loop/lid; other site 465817006440 ABC transporter signature motif; other site 465817006441 Walker B; other site 465817006442 D-loop; other site 465817006443 H-loop/switch region; other site 465817006444 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 465817006445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 465817006446 FtsX-like permease family; Region: FtsX; pfam02687 465817006447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817006448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817006449 metal binding site [ion binding]; metal-binding site 465817006450 active site 465817006451 I-site; other site 465817006452 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 465817006453 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 465817006454 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 465817006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817006456 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 465817006457 active site 465817006458 phosphorylation site [posttranslational modification] 465817006459 intermolecular recognition site; other site 465817006460 dimerization interface [polypeptide binding]; other site 465817006461 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 465817006462 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 465817006463 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 465817006464 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 465817006465 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 465817006466 FliG C-terminal domain; Region: FliG_C; pfam01706 465817006467 flagellar assembly protein H; Validated; Region: fliH; PRK05687 465817006468 Flagellar assembly protein FliH; Region: FliH; pfam02108 465817006469 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 465817006470 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 465817006471 Walker A motif/ATP binding site; other site 465817006472 Walker B motif; other site 465817006473 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 465817006474 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 465817006475 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 465817006476 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 465817006477 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 465817006478 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 465817006479 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 465817006480 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 465817006481 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 465817006482 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 465817006483 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 465817006484 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 465817006485 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 465817006486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817006487 DNA binding residues [nucleotide binding] 465817006488 dimerization interface [polypeptide binding]; other site 465817006489 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 465817006490 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 465817006491 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 465817006492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817006493 active site 465817006494 motif I; other site 465817006495 motif II; other site 465817006496 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 465817006497 transcription-repair coupling factor; Provisional; Region: PRK10689 465817006498 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 465817006499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817006500 ATP binding site [chemical binding]; other site 465817006501 putative Mg++ binding site [ion binding]; other site 465817006502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817006503 nucleotide binding region [chemical binding]; other site 465817006504 ATP-binding site [chemical binding]; other site 465817006505 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 465817006506 hypothetical protein; Provisional; Region: PRK11280 465817006507 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 465817006508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817006509 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 465817006510 beta-hexosaminidase; Provisional; Region: PRK05337 465817006511 thiamine kinase; Region: ycfN_thiK; TIGR02721 465817006512 active site 465817006513 substrate binding site [chemical binding]; other site 465817006514 ATP binding site [chemical binding]; other site 465817006515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 465817006516 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 465817006517 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 465817006518 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 465817006519 putative dimer interface [polypeptide binding]; other site 465817006520 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 465817006521 nucleotide binding site/active site [active] 465817006522 HIT family signature motif; other site 465817006523 catalytic residue [active] 465817006524 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 465817006525 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 465817006526 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 465817006527 active site turn [active] 465817006528 phosphorylation site [posttranslational modification] 465817006529 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 465817006530 active site 465817006531 DNA polymerase III subunit delta'; Validated; Region: PRK07993 465817006532 DNA polymerase III subunit delta'; Validated; Region: PRK08485 465817006533 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 465817006534 thymidylate kinase; Validated; Region: tmk; PRK00698 465817006535 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 465817006536 TMP-binding site; other site 465817006537 ATP-binding site [chemical binding]; other site 465817006538 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 465817006539 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 465817006540 dimerization interface [polypeptide binding]; other site 465817006541 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 465817006542 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 465817006543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817006544 catalytic residue [active] 465817006545 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 465817006546 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 465817006547 dimer interface [polypeptide binding]; other site 465817006548 active site 465817006549 acyl carrier protein; Provisional; Region: acpP; PRK00982 465817006550 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 465817006551 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 465817006552 NAD(P) binding site [chemical binding]; other site 465817006553 homotetramer interface [polypeptide binding]; other site 465817006554 homodimer interface [polypeptide binding]; other site 465817006555 active site 465817006556 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 465817006557 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 465817006558 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 465817006559 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 465817006560 dimer interface [polypeptide binding]; other site 465817006561 active site 465817006562 CoA binding pocket [chemical binding]; other site 465817006563 putative phosphate acyltransferase; Provisional; Region: PRK05331 465817006564 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 465817006565 hypothetical protein; Provisional; Region: PRK11193 465817006566 Maf-like protein; Region: Maf; pfam02545 465817006567 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 465817006568 active site 465817006569 dimer interface [polypeptide binding]; other site 465817006570 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 465817006571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817006572 RNA binding surface [nucleotide binding]; other site 465817006573 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 465817006574 active site 465817006575 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 465817006576 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 465817006577 homodimer interface [polypeptide binding]; other site 465817006578 oligonucleotide binding site [chemical binding]; other site 465817006579 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 465817006580 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 465817006581 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 465817006582 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 465817006583 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 465817006584 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 465817006585 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 465817006586 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 465817006587 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 465817006588 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 465817006589 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 465817006590 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 465817006591 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 465817006592 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 465817006593 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 465817006594 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 465817006595 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 465817006596 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 465817006597 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 465817006598 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 465817006599 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 465817006600 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 465817006601 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 465817006602 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 465817006603 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 465817006604 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 465817006605 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 465817006606 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 465817006607 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 465817006608 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 465817006609 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 465817006610 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 465817006611 SAF-like; Region: SAF_2; pfam13144 465817006612 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 465817006613 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 465817006614 FlgN protein; Region: FlgN; cl09176 465817006615 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 465817006616 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 465817006617 silverDB:etchr02034 465817006618 silverDB:etchr02035 465817006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 465817006620 hypothetical protein; Provisional; Region: PRK11239 465817006621 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 465817006622 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465817006623 glutaredoxin 2; Provisional; Region: PRK10387 465817006624 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 465817006625 C-terminal domain interface [polypeptide binding]; other site 465817006626 GSH binding site (G-site) [chemical binding]; other site 465817006627 catalytic residues [active] 465817006628 putative dimer interface [polypeptide binding]; other site 465817006629 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 465817006630 N-terminal domain interface [polypeptide binding]; other site 465817006631 lipoprotein; Provisional; Region: PRK10598 465817006632 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 465817006633 active site 465817006634 substrate binding pocket [chemical binding]; other site 465817006635 dimer interface [polypeptide binding]; other site 465817006636 DNA damage-inducible protein I; Provisional; Region: PRK10597 465817006637 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 465817006638 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 465817006639 hydroxyglutarate oxidase; Provisional; Region: PRK11728 465817006640 proline/glycine betaine transporter; Provisional; Region: PRK10642 465817006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006642 putative substrate translocation pore; other site 465817006643 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 465817006644 hypothetical protein; Provisional; Region: PRK03757 465817006645 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 465817006646 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 465817006647 active site residue [active] 465817006648 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 465817006649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 465817006650 putative acyl-acceptor binding pocket; other site 465817006651 secY/secA suppressor protein; Provisional; Region: PRK11467 465817006652 lipoprotein; Provisional; Region: PRK10175 465817006653 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 465817006654 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 465817006655 Ligand binding site; other site 465817006656 DXD motif; other site 465817006657 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 465817006658 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 465817006659 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 465817006660 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817006661 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 465817006662 PLD-like domain; Region: PLDc_2; pfam13091 465817006663 putative active site [active] 465817006664 catalytic site [active] 465817006665 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 465817006666 PLD-like domain; Region: PLDc_2; pfam13091 465817006667 putative active site [active] 465817006668 catalytic site [active] 465817006669 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 465817006670 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 465817006671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817006672 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817006673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465817006675 putative substrate translocation pore; other site 465817006676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 465817006677 MarR family; Region: MarR; pfam01047 465817006678 silverDB:etchr02061 465817006679 silverDB:etchr02062 465817006680 silverDB:etchr02063 465817006681 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 465817006682 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 465817006683 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 465817006684 GIY-YIG motif/motif A; other site 465817006685 active site 465817006686 catalytic site [active] 465817006687 putative DNA binding site [nucleotide binding]; other site 465817006688 metal binding site [ion binding]; metal-binding site 465817006689 UvrB/uvrC motif; Region: UVR; pfam02151 465817006690 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 465817006691 response regulator; Provisional; Region: PRK09483 465817006692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817006693 active site 465817006694 phosphorylation site [posttranslational modification] 465817006695 intermolecular recognition site; other site 465817006696 dimerization interface [polypeptide binding]; other site 465817006697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817006698 DNA binding residues [nucleotide binding] 465817006699 dimerization interface [polypeptide binding]; other site 465817006700 hypothetical protein; Provisional; Region: PRK10613 465817006701 GlpM protein; Region: GlpM; pfam06942 465817006702 Autoinducer synthetase; Region: Autoind_synth; cl17404 465817006703 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 465817006704 Autoinducer binding domain; Region: Autoind_bind; pfam03472 465817006705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817006706 DNA binding residues [nucleotide binding] 465817006707 dimerization interface [polypeptide binding]; other site 465817006708 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 465817006709 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 465817006710 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 465817006711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817006712 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 465817006713 EamA-like transporter family; Region: EamA; pfam00892 465817006714 hypothetical protein; Provisional; Region: PRK10174 465817006715 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 465817006716 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 465817006717 NAD(P) binding site [chemical binding]; other site 465817006718 catalytic residues [active] 465817006719 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 465817006720 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 465817006721 catalytic core [active] 465817006722 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 465817006723 YccA-like proteins; Region: YccA_like; cd10433 465817006724 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 465817006725 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 465817006726 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 465817006727 acylphosphatase; Provisional; Region: PRK14426 465817006728 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 465817006729 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 465817006730 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 465817006731 putative RNA binding site [nucleotide binding]; other site 465817006732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817006733 S-adenosylmethionine binding site [chemical binding]; other site 465817006734 heat shock protein HspQ; Provisional; Region: PRK14129 465817006735 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 465817006736 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 465817006737 hypothetical protein; Provisional; Region: PRK03641 465817006738 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 465817006739 active site 465817006740 dimer interfaces [polypeptide binding]; other site 465817006741 catalytic residues [active] 465817006742 DNA helicase IV; Provisional; Region: helD; PRK11054 465817006743 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 465817006744 Part of AAA domain; Region: AAA_19; pfam13245 465817006745 Family description; Region: UvrD_C_2; pfam13538 465817006746 hypothetical protein; Provisional; Region: PRK11770 465817006747 Domain of unknown function (DUF307); Region: DUF307; pfam03733 465817006748 Domain of unknown function (DUF307); Region: DUF307; pfam03733 465817006749 TIGR01666 family membrane protein; Region: YCCS 465817006750 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 465817006751 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465817006752 TfoX N-terminal domain; Region: TfoX_N; pfam04993 465817006753 TfoX C-terminal domain; Region: TfoX_C; pfam04994 465817006754 SOS cell division inhibitor; Provisional; Region: PRK10595 465817006755 outer membrane protein A; Reviewed; Region: PRK10808 465817006756 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 465817006757 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 465817006758 ligand binding site [chemical binding]; other site 465817006759 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 465817006760 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 465817006761 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 465817006762 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 465817006763 active site 1 [active] 465817006764 dimer interface [polypeptide binding]; other site 465817006765 active site 2 [active] 465817006766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 465817006767 Protein of unknown function (DUF330); Region: DUF330; pfam03886 465817006768 paraquat-inducible protein B; Provisional; Region: PRK10807 465817006769 mce related protein; Region: MCE; pfam02470 465817006770 mce related protein; Region: MCE; pfam02470 465817006771 mce related protein; Region: MCE; pfam02470 465817006772 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 465817006773 Paraquat-inducible protein A; Region: PqiA; pfam04403 465817006774 Paraquat-inducible protein A; Region: PqiA; pfam04403 465817006775 ABC transporter ATPase component; Reviewed; Region: PRK11147 465817006776 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817006777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817006778 ABC transporter; Region: ABC_tran_2; pfam12848 465817006779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817006780 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 465817006781 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 465817006782 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 465817006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817006784 S-adenosylmethionine binding site [chemical binding]; other site 465817006785 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 465817006786 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 465817006787 MOSC domain; Region: MOSC; pfam03473 465817006788 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465817006789 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 465817006790 catalytic loop [active] 465817006791 iron binding site [ion binding]; other site 465817006792 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 465817006793 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 465817006794 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 465817006795 quinone interaction residues [chemical binding]; other site 465817006796 active site 465817006797 catalytic residues [active] 465817006798 FMN binding site [chemical binding]; other site 465817006799 substrate binding site [chemical binding]; other site 465817006800 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 465817006801 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 465817006802 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 465817006803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817006804 substrate binding pocket [chemical binding]; other site 465817006805 membrane-bound complex binding site; other site 465817006806 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 465817006807 hinge residues; other site 465817006808 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 465817006809 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 465817006810 active site 465817006811 dimer interface [polypeptide binding]; other site 465817006812 non-prolyl cis peptide bond; other site 465817006813 insertion regions; other site 465817006814 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 465817006815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817006816 dimer interface [polypeptide binding]; other site 465817006817 conserved gate region; other site 465817006818 putative PBP binding loops; other site 465817006819 ABC-ATPase subunit interface; other site 465817006820 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 465817006821 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 465817006822 Walker A/P-loop; other site 465817006823 ATP binding site [chemical binding]; other site 465817006824 Q-loop/lid; other site 465817006825 ABC transporter signature motif; other site 465817006826 Walker B; other site 465817006827 D-loop; other site 465817006828 H-loop/switch region; other site 465817006829 aminopeptidase N; Provisional; Region: pepN; PRK14015 465817006830 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 465817006831 active site 465817006832 Zn binding site [ion binding]; other site 465817006833 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 465817006834 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 465817006835 active site 465817006836 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 465817006837 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 465817006838 putative dimer interface [polypeptide binding]; other site 465817006839 putative anticodon binding site; other site 465817006840 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 465817006841 homodimer interface [polypeptide binding]; other site 465817006842 motif 1; other site 465817006843 motif 2; other site 465817006844 active site 465817006845 motif 3; other site 465817006846 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 465817006847 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 465817006848 trimer interface [polypeptide binding]; other site 465817006849 eyelet of channel; other site 465817006850 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 465817006851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817006852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817006853 homodimer interface [polypeptide binding]; other site 465817006854 catalytic residue [active] 465817006855 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 465817006856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 465817006857 Peptidase M15; Region: Peptidase_M15_3; cl01194 465817006858 murein L,D-transpeptidase; Provisional; Region: PRK10594 465817006859 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 465817006860 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 465817006861 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 465817006862 cell division protein MukB; Provisional; Region: mukB; PRK04863 465817006863 P-loop containing region of AAA domain; Region: AAA_29; cl17516 465817006864 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 465817006865 condesin subunit E; Provisional; Region: PRK05256 465817006866 condesin subunit F; Provisional; Region: PRK05260 465817006867 Methyltransferase domain; Region: Methyltransf_23; pfam13489 465817006868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817006869 S-adenosylmethionine binding site [chemical binding]; other site 465817006870 Uncharacterized conserved protein [Function unknown]; Region: COG1434 465817006871 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 465817006872 putative active site [active] 465817006873 hypothetical protein; Provisional; Region: PRK10593 465817006874 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 465817006875 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 465817006876 Ligand binding site; other site 465817006877 oligomer interface; other site 465817006878 Trm112p-like protein; Region: Trm112p; cl01066 465817006879 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 465817006880 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 465817006881 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 465817006882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817006883 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 465817006884 Walker A/P-loop; other site 465817006885 ATP binding site [chemical binding]; other site 465817006886 Q-loop/lid; other site 465817006887 ABC transporter signature motif; other site 465817006888 Walker B; other site 465817006889 D-loop; other site 465817006890 H-loop/switch region; other site 465817006891 ComEC family competence protein; Provisional; Region: PRK11539 465817006892 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 465817006893 Competence protein; Region: Competence; pfam03772 465817006894 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 465817006895 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 465817006896 IHF dimer interface [polypeptide binding]; other site 465817006897 IHF - DNA interface [nucleotide binding]; other site 465817006898 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 465817006899 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 465817006900 RNA binding site [nucleotide binding]; other site 465817006901 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 465817006902 RNA binding site [nucleotide binding]; other site 465817006903 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 465817006904 RNA binding site [nucleotide binding]; other site 465817006905 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465817006906 RNA binding site [nucleotide binding]; other site 465817006907 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 465817006908 RNA binding site [nucleotide binding]; other site 465817006909 cytidylate kinase; Provisional; Region: cmk; PRK00023 465817006910 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 465817006911 CMP-binding site; other site 465817006912 The sites determining sugar specificity; other site 465817006913 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 465817006914 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 465817006915 hinge; other site 465817006916 active site 465817006917 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 465817006918 homodimer interface [polypeptide binding]; other site 465817006919 substrate-cofactor binding pocket; other site 465817006920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817006921 catalytic residue [active] 465817006922 uncharacterized domain; Region: TIGR00702 465817006923 YcaO-like family; Region: YcaO; pfam02624 465817006924 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 465817006925 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 465817006926 Pyruvate formate lyase 1; Region: PFL1; cd01678 465817006927 coenzyme A binding site [chemical binding]; other site 465817006928 active site 465817006929 catalytic residues [active] 465817006930 glycine loop; other site 465817006931 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 465817006932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817006933 FeS/SAM binding site; other site 465817006934 putative MFS family transporter protein; Provisional; Region: PRK03633 465817006935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817006936 putative substrate translocation pore; other site 465817006937 seryl-tRNA synthetase; Provisional; Region: PRK05431 465817006938 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 465817006939 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 465817006940 dimer interface [polypeptide binding]; other site 465817006941 active site 465817006942 motif 1; other site 465817006943 motif 2; other site 465817006944 motif 3; other site 465817006945 recombination factor protein RarA; Reviewed; Region: PRK13342 465817006946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817006947 Walker A motif; other site 465817006948 ATP binding site [chemical binding]; other site 465817006949 Walker B motif; other site 465817006950 arginine finger; other site 465817006951 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 465817006952 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 465817006953 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 465817006954 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 465817006955 DNA translocase FtsK; Provisional; Region: PRK10263 465817006956 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 465817006957 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 465817006958 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 465817006959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465817006960 putative DNA binding site [nucleotide binding]; other site 465817006961 putative Zn2+ binding site [ion binding]; other site 465817006962 AsnC family; Region: AsnC_trans_reg; pfam01037 465817006963 thioredoxin reductase; Provisional; Region: PRK10262 465817006964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465817006965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817006966 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 465817006967 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817006968 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 465817006969 Walker A/P-loop; other site 465817006970 ATP binding site [chemical binding]; other site 465817006971 Q-loop/lid; other site 465817006972 ABC transporter signature motif; other site 465817006973 Walker B; other site 465817006974 D-loop; other site 465817006975 H-loop/switch region; other site 465817006976 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 465817006977 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 465817006978 Walker A/P-loop; other site 465817006979 ATP binding site [chemical binding]; other site 465817006980 Q-loop/lid; other site 465817006981 ABC transporter signature motif; other site 465817006982 Walker B; other site 465817006983 D-loop; other site 465817006984 H-loop/switch region; other site 465817006985 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 465817006986 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 465817006987 rRNA binding site [nucleotide binding]; other site 465817006988 predicted 30S ribosome binding site; other site 465817006989 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 465817006990 Clp amino terminal domain; Region: Clp_N; pfam02861 465817006991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817006992 Walker A motif; other site 465817006993 ATP binding site [chemical binding]; other site 465817006994 Walker B motif; other site 465817006995 arginine finger; other site 465817006996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817006997 Walker A motif; other site 465817006998 ATP binding site [chemical binding]; other site 465817006999 Walker B motif; other site 465817007000 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 465817007001 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 465817007002 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 465817007003 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 465817007004 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 465817007005 putative active site [active] 465817007006 putative metal-binding site [ion binding]; other site 465817007007 pyruvate dehydrogenase; Provisional; Region: PRK09124 465817007008 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 465817007009 PYR/PP interface [polypeptide binding]; other site 465817007010 dimer interface [polypeptide binding]; other site 465817007011 tetramer interface [polypeptide binding]; other site 465817007012 TPP binding site [chemical binding]; other site 465817007013 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817007014 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 465817007015 TPP-binding site [chemical binding]; other site 465817007016 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 465817007017 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 465817007018 amidase catalytic site [active] 465817007019 Zn binding residues [ion binding]; other site 465817007020 substrate binding site [chemical binding]; other site 465817007021 hypothetical protein; Provisional; Region: PRK02877 465817007022 putative lipoprotein; Provisional; Region: PRK10533 465817007023 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 465817007024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007025 Walker A/P-loop; other site 465817007026 ATP binding site [chemical binding]; other site 465817007027 Q-loop/lid; other site 465817007028 ABC transporter signature motif; other site 465817007029 Walker B; other site 465817007030 D-loop; other site 465817007031 H-loop/switch region; other site 465817007032 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 465817007033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817007034 substrate binding pocket [chemical binding]; other site 465817007035 membrane-bound complex binding site; other site 465817007036 hinge residues; other site 465817007037 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007039 dimer interface [polypeptide binding]; other site 465817007040 conserved gate region; other site 465817007041 putative PBP binding loops; other site 465817007042 ABC-ATPase subunit interface; other site 465817007043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007044 dimer interface [polypeptide binding]; other site 465817007045 conserved gate region; other site 465817007046 putative PBP binding loops; other site 465817007047 ABC-ATPase subunit interface; other site 465817007048 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 465817007049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817007050 substrate binding pocket [chemical binding]; other site 465817007051 membrane-bound complex binding site; other site 465817007052 hinge residues; other site 465817007053 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 465817007054 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 465817007055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007056 dimer interface [polypeptide binding]; other site 465817007057 conserved gate region; other site 465817007058 putative PBP binding loops; other site 465817007059 ABC-ATPase subunit interface; other site 465817007060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007061 dimer interface [polypeptide binding]; other site 465817007062 conserved gate region; other site 465817007063 putative PBP binding loops; other site 465817007064 ABC-ATPase subunit interface; other site 465817007065 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 465817007066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007067 Walker A/P-loop; other site 465817007068 ATP binding site [chemical binding]; other site 465817007069 Q-loop/lid; other site 465817007070 ABC transporter signature motif; other site 465817007071 Walker B; other site 465817007072 D-loop; other site 465817007073 H-loop/switch region; other site 465817007074 TOBE domain; Region: TOBE_2; pfam08402 465817007075 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 465817007076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 465817007077 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 465817007078 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 465817007079 dimer interface [polypeptide binding]; other site 465817007080 FMN binding site [chemical binding]; other site 465817007081 NADPH bind site [chemical binding]; other site 465817007082 hypothetical protein; Provisional; Region: PRK10591 465817007083 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 465817007084 GSH binding site [chemical binding]; other site 465817007085 catalytic residues [active] 465817007086 putative transporter; Provisional; Region: PRK04972 465817007087 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 465817007088 TrkA-C domain; Region: TrkA_C; pfam02080 465817007089 TrkA-C domain; Region: TrkA_C; pfam02080 465817007090 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 465817007091 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 465817007092 active site 465817007093 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 465817007094 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 465817007095 active site 465817007096 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 465817007097 serine transporter; Region: stp; TIGR00814 465817007098 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 465817007099 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 465817007100 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 465817007101 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 465817007102 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 465817007103 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 465817007104 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 465817007105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007106 dimer interface [polypeptide binding]; other site 465817007107 conserved gate region; other site 465817007108 putative PBP binding loops; other site 465817007109 ABC-ATPase subunit interface; other site 465817007110 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 465817007111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007112 dimer interface [polypeptide binding]; other site 465817007113 conserved gate region; other site 465817007114 putative PBP binding loops; other site 465817007115 ABC-ATPase subunit interface; other site 465817007116 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 465817007117 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 465817007118 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 465817007119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817007120 Walker A/P-loop; other site 465817007121 ATP binding site [chemical binding]; other site 465817007122 Q-loop/lid; other site 465817007123 ABC transporter signature motif; other site 465817007124 Walker B; other site 465817007125 D-loop; other site 465817007126 H-loop/switch region; other site 465817007127 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 465817007128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817007129 Walker A/P-loop; other site 465817007130 ATP binding site [chemical binding]; other site 465817007131 Q-loop/lid; other site 465817007132 ABC transporter signature motif; other site 465817007133 Walker B; other site 465817007134 D-loop; other site 465817007135 H-loop/switch region; other site 465817007136 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 465817007137 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 465817007138 catalytic nucleophile [active] 465817007139 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 465817007140 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 465817007141 dimer interface [polypeptide binding]; other site 465817007142 putative functional site; other site 465817007143 putative MPT binding site; other site 465817007144 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 465817007145 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 465817007146 ATP binding site [chemical binding]; other site 465817007147 substrate interface [chemical binding]; other site 465817007148 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 465817007149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817007150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007151 Walker A/P-loop; other site 465817007152 ATP binding site [chemical binding]; other site 465817007153 ABC transporter signature motif; other site 465817007154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817007155 Walker B; other site 465817007156 ABC transporter; Region: ABC_tran_2; pfam12848 465817007157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817007158 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 465817007159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007160 putative substrate translocation pore; other site 465817007161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007162 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 465817007163 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 465817007164 dimer interface [polypeptide binding]; other site 465817007165 ligand binding site [chemical binding]; other site 465817007166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 465817007167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817007168 dimer interface [polypeptide binding]; other site 465817007169 putative CheW interface [polypeptide binding]; other site 465817007170 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 465817007171 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 465817007172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007173 putative substrate translocation pore; other site 465817007174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007175 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 465817007176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817007177 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817007178 manganese transport regulator MntR; Provisional; Region: PRK11050 465817007179 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 465817007180 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 465817007181 outer membrane protein X; Provisional; Region: ompX; PRK09408 465817007182 threonine and homoserine efflux system; Provisional; Region: PRK10532 465817007183 EamA-like transporter family; Region: EamA; pfam00892 465817007184 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 465817007185 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 465817007186 dimerization interface [polypeptide binding]; other site 465817007187 DPS ferroxidase diiron center [ion binding]; other site 465817007188 ion pore; other site 465817007189 hypothetical protein; Provisional; Region: PRK11019 465817007190 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 465817007191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817007192 substrate binding pocket [chemical binding]; other site 465817007193 membrane-bound complex binding site; other site 465817007194 hinge residues; other site 465817007195 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817007196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007197 dimer interface [polypeptide binding]; other site 465817007198 conserved gate region; other site 465817007199 putative PBP binding loops; other site 465817007200 ABC-ATPase subunit interface; other site 465817007201 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 465817007202 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817007203 Walker A/P-loop; other site 465817007204 ATP binding site [chemical binding]; other site 465817007205 Q-loop/lid; other site 465817007206 ABC transporter signature motif; other site 465817007207 Walker B; other site 465817007208 D-loop; other site 465817007209 H-loop/switch region; other site 465817007210 putative mechanosensitive channel protein; Provisional; Region: PRK11465 465817007211 Mechanosensitive ion channel; Region: MS_channel; pfam00924 465817007212 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 465817007213 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 465817007214 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 465817007215 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 465817007216 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 465817007217 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 465817007218 putative active site [active] 465817007219 putative NTP binding site [chemical binding]; other site 465817007220 putative nucleic acid binding site [nucleotide binding]; other site 465817007221 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 465817007222 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 465817007223 putative active site [active] 465817007224 putative NTP binding site [chemical binding]; other site 465817007225 putative nucleic acid binding site [nucleotide binding]; other site 465817007226 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 465817007227 N-formylglutamate amidohydrolase; Region: FGase; cl01522 465817007228 imidazolonepropionase; Validated; Region: PRK09356 465817007229 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 465817007230 active site 465817007231 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 465817007232 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 465817007233 active site 465817007234 HutD; Region: HutD; cl01532 465817007235 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 465817007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817007237 DNA-binding site [nucleotide binding]; DNA binding site 465817007238 UTRA domain; Region: UTRA; pfam07702 465817007239 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 465817007240 active sites [active] 465817007241 tetramer interface [polypeptide binding]; other site 465817007242 urocanate hydratase; Provisional; Region: PRK05414 465817007243 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 465817007244 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 465817007245 metal binding site [ion binding]; metal-binding site 465817007246 putative dimer interface [polypeptide binding]; other site 465817007247 glycosyl transferase family protein; Provisional; Region: PRK08136 465817007248 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 465817007249 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 465817007250 DEAD_2; Region: DEAD_2; pfam06733 465817007251 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 465817007252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817007253 Coenzyme A binding pocket [chemical binding]; other site 465817007254 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 465817007255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817007256 non-specific DNA binding site [nucleotide binding]; other site 465817007257 salt bridge; other site 465817007258 sequence-specific DNA binding site [nucleotide binding]; other site 465817007259 transcriptional regulator MirA; Provisional; Region: PRK15043 465817007260 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 465817007261 DNA binding residues [nucleotide binding] 465817007262 SnoaL-like domain; Region: SnoaL_2; pfam12680 465817007263 short chain dehydrogenase; Provisional; Region: PRK06101 465817007264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817007265 NAD(P) binding site [chemical binding]; other site 465817007266 active site 465817007267 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 465817007268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 465817007269 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 465817007270 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 465817007271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817007272 S-adenosylmethionine binding site [chemical binding]; other site 465817007273 hypothetical protein; Provisional; Region: PRK13681 465817007274 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 465817007275 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 465817007276 active site 465817007277 metal binding site [ion binding]; metal-binding site 465817007278 nudix motif; other site 465817007279 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 465817007280 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 465817007281 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 465817007282 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 465817007283 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 465817007284 D-lactate dehydrogenase; Provisional; Region: PRK11183 465817007285 FAD binding domain; Region: FAD_binding_4; pfam01565 465817007286 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 465817007287 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 465817007288 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 465817007289 Mechanosensitive ion channel; Region: MS_channel; pfam00924 465817007290 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 465817007291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817007292 Coenzyme A binding pocket [chemical binding]; other site 465817007293 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 465817007294 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 465817007295 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 465817007296 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465817007297 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 465817007298 L,D-transpeptidase; Provisional; Region: PRK10260 465817007299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 465817007300 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 465817007301 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 465817007302 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 465817007303 FMN binding site [chemical binding]; other site 465817007304 active site 465817007305 catalytic residues [active] 465817007306 substrate binding site [chemical binding]; other site 465817007307 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 465817007308 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 465817007309 ATP binding site [chemical binding]; other site 465817007310 Mg++ binding site [ion binding]; other site 465817007311 motif III; other site 465817007312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817007313 nucleotide binding region [chemical binding]; other site 465817007314 ATP-binding site [chemical binding]; other site 465817007315 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 465817007316 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 465817007317 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 465817007318 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 465817007319 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 465817007320 MoaE homodimer interface [polypeptide binding]; other site 465817007321 MoaD interaction [polypeptide binding]; other site 465817007322 active site residues [active] 465817007323 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 465817007324 MoaE interaction surface [polypeptide binding]; other site 465817007325 MoeB interaction surface [polypeptide binding]; other site 465817007326 thiocarboxylated glycine; other site 465817007327 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 465817007328 trimer interface [polypeptide binding]; other site 465817007329 dimer interface [polypeptide binding]; other site 465817007330 putative active site [active] 465817007331 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 465817007332 MPT binding site; other site 465817007333 trimer interface [polypeptide binding]; other site 465817007334 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 465817007335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817007336 FeS/SAM binding site; other site 465817007337 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 465817007338 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 465817007339 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 465817007340 phosphate binding site [ion binding]; other site 465817007341 putative substrate binding pocket [chemical binding]; other site 465817007342 dimer interface [polypeptide binding]; other site 465817007343 excinuclease ABC subunit B; Provisional; Region: PRK05298 465817007344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817007345 ATP binding site [chemical binding]; other site 465817007346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 465817007347 nucleotide binding region [chemical binding]; other site 465817007348 ATP-binding site [chemical binding]; other site 465817007349 Ultra-violet resistance protein B; Region: UvrB; pfam12344 465817007350 UvrB/uvrC motif; Region: UVR; pfam02151 465817007351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 465817007352 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 465817007353 Walker A/P-loop; other site 465817007354 ATP binding site [chemical binding]; other site 465817007355 Q-loop/lid; other site 465817007356 ABC transporter signature motif; other site 465817007357 Walker B; other site 465817007358 D-loop; other site 465817007359 H-loop/switch region; other site 465817007360 AAA domain; Region: AAA_26; pfam13500 465817007361 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 465817007362 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 465817007363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817007364 S-adenosylmethionine binding site [chemical binding]; other site 465817007365 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 465817007366 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 465817007367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817007368 catalytic residue [active] 465817007369 biotin synthase; Provisional; Region: PRK15108 465817007370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817007371 FeS/SAM binding site; other site 465817007372 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 465817007373 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 465817007374 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817007375 inhibitor-cofactor binding pocket; inhibition site 465817007376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817007377 catalytic residue [active] 465817007378 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 465817007379 Prostaglandin dehydrogenases; Region: PGDH; cd05288 465817007380 NAD(P) binding site [chemical binding]; other site 465817007381 substrate binding site [chemical binding]; other site 465817007382 dimer interface [polypeptide binding]; other site 465817007383 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 465817007384 substrate binding site [chemical binding]; other site 465817007385 6-phosphogluconolactonase; Provisional; Region: PRK11028 465817007386 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 465817007387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007388 active site 465817007389 motif I; other site 465817007390 motif II; other site 465817007391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007392 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 465817007393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007394 Walker A/P-loop; other site 465817007395 ATP binding site [chemical binding]; other site 465817007396 Q-loop/lid; other site 465817007397 ABC transporter signature motif; other site 465817007398 Walker B; other site 465817007399 D-loop; other site 465817007400 H-loop/switch region; other site 465817007401 molybdenum-pterin binding domain; Region: Mop; TIGR00638 465817007402 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 465817007403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007404 dimer interface [polypeptide binding]; other site 465817007405 conserved gate region; other site 465817007406 putative PBP binding loops; other site 465817007407 ABC-ATPase subunit interface; other site 465817007408 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 465817007409 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 465817007410 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 465817007411 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 465817007412 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 465817007413 TOBE domain; Region: TOBE; cl01440 465817007414 TOBE domain; Region: TOBE; cl01440 465817007415 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 465817007416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007417 Walker A/P-loop; other site 465817007418 ATP binding site [chemical binding]; other site 465817007419 Q-loop/lid; other site 465817007420 ABC transporter signature motif; other site 465817007421 Walker B; other site 465817007422 D-loop; other site 465817007423 H-loop/switch region; other site 465817007424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817007425 Walker A/P-loop; other site 465817007426 ATP binding site [chemical binding]; other site 465817007427 Q-loop/lid; other site 465817007428 ABC transporter signature motif; other site 465817007429 Walker B; other site 465817007430 D-loop; other site 465817007431 H-loop/switch region; other site 465817007432 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 465817007433 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 465817007434 dimer interface [polypeptide binding]; other site 465817007435 active site 465817007436 galactokinase; Provisional; Region: PRK05101 465817007437 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 465817007438 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 465817007439 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 465817007440 active site 465817007441 catalytic residues [active] 465817007442 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465817007443 catalytic core [active] 465817007444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 465817007445 RHS Repeat; Region: RHS_repeat; pfam05593 465817007446 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817007447 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 465817007448 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 465817007449 YbgS-like protein; Region: YbgS; pfam13985 465817007450 zinc transporter ZitB; Provisional; Region: PRK03557 465817007451 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 465817007452 quinolinate synthetase; Provisional; Region: PRK09375 465817007453 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 465817007454 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 465817007455 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 465817007456 DNA binding site [nucleotide binding] 465817007457 active site 465817007458 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 465817007459 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 465817007460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817007461 AlkA N-terminal domain; Region: AlkA_N; pfam06029 465817007462 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 465817007463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 465817007464 minor groove reading motif; other site 465817007465 helix-hairpin-helix signature motif; other site 465817007466 substrate binding pocket [chemical binding]; other site 465817007467 active site 465817007468 tol-pal system protein YbgF; Provisional; Region: PRK10803 465817007469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 465817007470 TPR motif; other site 465817007471 binding surface 465817007472 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 465817007473 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 465817007474 ligand binding site [chemical binding]; other site 465817007475 translocation protein TolB; Provisional; Region: tolB; PRK03629 465817007476 TolB amino-terminal domain; Region: TolB_N; pfam04052 465817007477 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 465817007478 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 465817007479 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 465817007480 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 465817007481 TolA C-terminal; Region: TolA; pfam06519 465817007482 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 465817007483 colicin uptake protein TolR; Provisional; Region: PRK11024 465817007484 colicin uptake protein TolQ; Provisional; Region: PRK10801 465817007485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465817007486 active site 465817007487 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 465817007488 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 465817007489 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 465817007490 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 465817007491 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 465817007492 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 465817007493 CoA binding domain; Region: CoA_binding; pfam02629 465817007494 CoA-ligase; Region: Ligase_CoA; pfam00549 465817007495 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 465817007496 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 465817007497 CoA-ligase; Region: Ligase_CoA; pfam00549 465817007498 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 465817007499 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465817007500 E3 interaction surface; other site 465817007501 lipoyl attachment site [posttranslational modification]; other site 465817007502 e3 binding domain; Region: E3_binding; pfam02817 465817007503 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 465817007504 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 465817007505 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 465817007506 TPP-binding site [chemical binding]; other site 465817007507 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 465817007508 dimer interface [polypeptide binding]; other site 465817007509 PYR/PP interface [polypeptide binding]; other site 465817007510 TPP binding site [chemical binding]; other site 465817007511 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 465817007512 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 465817007513 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 465817007514 L-aspartate oxidase; Provisional; Region: PRK06175 465817007515 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 465817007516 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 465817007517 SdhC subunit interface [polypeptide binding]; other site 465817007518 proximal heme binding site [chemical binding]; other site 465817007519 cardiolipin binding site; other site 465817007520 Iron-sulfur protein interface; other site 465817007521 proximal quinone binding site [chemical binding]; other site 465817007522 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 465817007523 Iron-sulfur protein interface; other site 465817007524 proximal quinone binding site [chemical binding]; other site 465817007525 SdhD (CybS) interface [polypeptide binding]; other site 465817007526 proximal heme binding site [chemical binding]; other site 465817007527 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 465817007528 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 465817007529 dimer interface [polypeptide binding]; other site 465817007530 active site 465817007531 citrylCoA binding site [chemical binding]; other site 465817007532 NADH binding [chemical binding]; other site 465817007533 cationic pore residues; other site 465817007534 oxalacetate/citrate binding site [chemical binding]; other site 465817007535 coenzyme A binding site [chemical binding]; other site 465817007536 catalytic triad [active] 465817007537 endonuclease VIII; Provisional; Region: PRK10445 465817007538 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 465817007539 DNA binding site [nucleotide binding] 465817007540 catalytic residue [active] 465817007541 putative catalytic residues [active] 465817007542 H2TH interface [polypeptide binding]; other site 465817007543 intercalation triad [nucleotide binding]; other site 465817007544 substrate specificity determining residue; other site 465817007545 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 465817007546 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 465817007547 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 465817007548 putative substrate binding pocket [chemical binding]; other site 465817007549 AC domain interface; other site 465817007550 catalytic triad [active] 465817007551 AB domain interface; other site 465817007552 interchain disulfide; other site 465817007553 Predicted membrane protein [Function unknown]; Region: COG3817 465817007554 Protein of unknown function (DUF979); Region: DUF979; pfam06166 465817007555 Predicted membrane protein [Function unknown]; Region: COG3819 465817007556 LamB/YcsF family protein; Provisional; Region: PRK05406 465817007557 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 465817007558 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 465817007559 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 465817007560 Uncharacterized conserved protein [Function unknown]; Region: COG0327 465817007561 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 465817007562 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 465817007563 DNA photolyase; Region: DNA_photolyase; pfam00875 465817007564 Protein of unknown function (DUF523); Region: DUF523; pfam04463 465817007565 Uncharacterized conserved protein [Function unknown]; Region: COG3272 465817007566 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 465817007567 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 465817007568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817007569 active site 465817007570 phosphorylation site [posttranslational modification] 465817007571 intermolecular recognition site; other site 465817007572 dimerization interface [polypeptide binding]; other site 465817007573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817007574 DNA binding site [nucleotide binding] 465817007575 phosphoglucomutase; Validated; Region: PRK07564 465817007576 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 465817007577 active site 465817007578 substrate binding site [chemical binding]; other site 465817007579 metal binding site [ion binding]; metal-binding site 465817007580 replication initiation regulator SeqA; Provisional; Region: PRK11187 465817007581 acyl-CoA esterase; Provisional; Region: PRK10673 465817007582 PGAP1-like protein; Region: PGAP1; pfam07819 465817007583 LexA regulated protein; Provisional; Region: PRK11675 465817007584 flavodoxin FldA; Validated; Region: PRK09267 465817007585 ferric uptake regulator; Provisional; Region: fur; PRK09462 465817007586 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 465817007587 metal binding site 2 [ion binding]; metal-binding site 465817007588 putative DNA binding helix; other site 465817007589 metal binding site 1 [ion binding]; metal-binding site 465817007590 dimer interface [polypeptide binding]; other site 465817007591 structural Zn2+ binding site [ion binding]; other site 465817007592 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 465817007593 aromatic amino acid transport protein; Region: araaP; TIGR00837 465817007594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 465817007595 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 465817007596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465817007597 active site 465817007598 HIGH motif; other site 465817007599 nucleotide binding site [chemical binding]; other site 465817007600 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 465817007601 KMSKS motif; other site 465817007602 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 465817007603 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 465817007604 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 465817007605 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 465817007606 active site turn [active] 465817007607 phosphorylation site [posttranslational modification] 465817007608 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 465817007609 HPr interaction site; other site 465817007610 glycerol kinase (GK) interaction site [polypeptide binding]; other site 465817007611 active site 465817007612 phosphorylation site [posttranslational modification] 465817007613 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 465817007614 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 465817007615 active site 465817007616 trimer interface [polypeptide binding]; other site 465817007617 allosteric site; other site 465817007618 active site lid [active] 465817007619 hexamer (dimer of trimers) interface [polypeptide binding]; other site 465817007620 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 465817007621 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 465817007622 active site 465817007623 dimer interface [polypeptide binding]; other site 465817007624 MarR family; Region: MarR_2; cl17246 465817007625 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 465817007626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 465817007627 nucleotide binding site [chemical binding]; other site 465817007628 UMP phosphatase; Provisional; Region: PRK10444 465817007629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007630 active site 465817007631 motif I; other site 465817007632 motif II; other site 465817007633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007634 asparagine synthetase B; Provisional; Region: asnB; PRK09431 465817007635 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 465817007636 active site 465817007637 dimer interface [polypeptide binding]; other site 465817007638 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 465817007639 Ligand Binding Site [chemical binding]; other site 465817007640 Molecular Tunnel; other site 465817007641 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 465817007642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 465817007643 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 465817007644 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 465817007645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817007646 FeS/SAM binding site; other site 465817007647 TRAM domain; Region: TRAM; pfam01938 465817007648 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 465817007649 PhoH-like protein; Region: PhoH; pfam02562 465817007650 metal-binding heat shock protein; Provisional; Region: PRK00016 465817007651 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 465817007652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465817007653 Transporter associated domain; Region: CorC_HlyC; smart01091 465817007654 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 465817007655 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 465817007656 putative active site [active] 465817007657 catalytic triad [active] 465817007658 putative dimer interface [polypeptide binding]; other site 465817007659 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 465817007660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817007661 substrate binding pocket [chemical binding]; other site 465817007662 membrane-bound complex binding site; other site 465817007663 hinge residues; other site 465817007664 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817007665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007666 dimer interface [polypeptide binding]; other site 465817007667 conserved gate region; other site 465817007668 putative PBP binding loops; other site 465817007669 ABC-ATPase subunit interface; other site 465817007670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817007671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007672 dimer interface [polypeptide binding]; other site 465817007673 conserved gate region; other site 465817007674 putative PBP binding loops; other site 465817007675 ABC-ATPase subunit interface; other site 465817007676 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817007677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817007678 Walker A/P-loop; other site 465817007679 ATP binding site [chemical binding]; other site 465817007680 Q-loop/lid; other site 465817007681 ABC transporter signature motif; other site 465817007682 Walker B; other site 465817007683 D-loop; other site 465817007684 H-loop/switch region; other site 465817007685 hypothetical protein; Provisional; Region: PRK11032 465817007686 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 465817007687 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 465817007688 HIGH motif; other site 465817007689 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 465817007690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 465817007691 active site 465817007692 KMSKS motif; other site 465817007693 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 465817007694 tRNA binding surface [nucleotide binding]; other site 465817007695 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 465817007696 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 465817007697 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 465817007698 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 465817007699 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 465817007700 active site 465817007701 (T/H)XGH motif; other site 465817007702 ribosome-associated protein; Provisional; Region: PRK11538 465817007703 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 465817007704 penicillin-binding protein 2; Provisional; Region: PRK10795 465817007705 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 465817007706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 465817007707 cell wall shape-determining protein; Provisional; Region: PRK10794 465817007708 rare lipoprotein A; Provisional; Region: PRK10672 465817007709 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 465817007710 Sporulation related domain; Region: SPOR; pfam05036 465817007711 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 465817007712 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 465817007713 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 465817007714 hypothetical protein; Provisional; Region: PRK04998 465817007715 lipoate-protein ligase B; Provisional; Region: PRK14342 465817007716 lipoyl synthase; Provisional; Region: PRK05481 465817007717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817007718 FeS/SAM binding site; other site 465817007719 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 465817007720 Predicted amidohydrolase [General function prediction only]; Region: COG0388 465817007721 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 465817007722 putative active site [active] 465817007723 catalytic triad [active] 465817007724 putative dimer interface [polypeptide binding]; other site 465817007725 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465817007726 DNA-binding site [nucleotide binding]; DNA binding site 465817007727 RNA-binding motif; other site 465817007728 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 465817007729 putative transporter; Provisional; Region: PRK09821 465817007730 GntP family permease; Region: GntP_permease; pfam02447 465817007731 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 465817007732 putative aldolase; Validated; Region: PRK08130 465817007733 intersubunit interface [polypeptide binding]; other site 465817007734 active site 465817007735 Zn2+ binding site [ion binding]; other site 465817007736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 465817007737 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 465817007738 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 465817007739 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 465817007740 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 465817007741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 465817007742 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 465817007743 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 465817007744 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 465817007745 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 465817007746 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 465817007747 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 465817007748 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 465817007749 Walker A/P-loop; other site 465817007750 ATP binding site [chemical binding]; other site 465817007751 Q-loop/lid; other site 465817007752 ABC transporter signature motif; other site 465817007753 Walker B; other site 465817007754 D-loop; other site 465817007755 H-loop/switch region; other site 465817007756 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 465817007757 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 465817007758 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 465817007759 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 465817007760 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 465817007761 putative active site [active] 465817007762 putative catalytic site [active] 465817007763 putative Zn binding site [ion binding]; other site 465817007764 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 465817007765 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 465817007766 active site 465817007767 substrate binding site [chemical binding]; other site 465817007768 cosubstrate binding site; other site 465817007769 catalytic site [active] 465817007770 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 465817007771 active site 465817007772 hexamer interface [polypeptide binding]; other site 465817007773 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 465817007774 NAD binding site [chemical binding]; other site 465817007775 substrate binding site [chemical binding]; other site 465817007776 active site 465817007777 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 465817007778 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 465817007779 Ligand binding site; other site 465817007780 Putative Catalytic site; other site 465817007781 DXD motif; other site 465817007782 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 465817007783 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 465817007784 inhibitor-cofactor binding pocket; inhibition site 465817007785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817007786 catalytic residue [active] 465817007787 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 465817007788 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 465817007789 Trp docking motif [polypeptide binding]; other site 465817007790 putative active site [active] 465817007791 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 465817007792 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817007793 N-terminal plug; other site 465817007794 ligand-binding site [chemical binding]; other site 465817007795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 465817007796 classical (c) SDRs; Region: SDR_c; cd05233 465817007797 NAD(P) binding site [chemical binding]; other site 465817007798 active site 465817007799 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 465817007800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817007801 Walker A/P-loop; other site 465817007802 ATP binding site [chemical binding]; other site 465817007803 Q-loop/lid; other site 465817007804 ABC transporter signature motif; other site 465817007805 Walker B; other site 465817007806 D-loop; other site 465817007807 H-loop/switch region; other site 465817007808 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817007809 Walker A/P-loop; other site 465817007810 ATP binding site [chemical binding]; other site 465817007811 Q-loop/lid; other site 465817007812 ABC transporter signature motif; other site 465817007813 Walker B; other site 465817007814 D-loop; other site 465817007815 H-loop/switch region; other site 465817007816 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 465817007817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007818 dimer interface [polypeptide binding]; other site 465817007819 conserved gate region; other site 465817007820 ABC-ATPase subunit interface; other site 465817007821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465817007822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817007823 dimer interface [polypeptide binding]; other site 465817007824 conserved gate region; other site 465817007825 putative PBP binding loops; other site 465817007826 ABC-ATPase subunit interface; other site 465817007827 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817007828 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 465817007829 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 465817007830 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 465817007831 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 465817007832 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 465817007833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007834 putative substrate translocation pore; other site 465817007835 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 465817007836 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 465817007837 catalytic site [active] 465817007838 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817007839 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817007840 active site 465817007841 catalytic tetrad [active] 465817007842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817007843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817007844 active site 465817007845 catalytic tetrad [active] 465817007846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817007847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817007848 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 465817007849 putative effector binding pocket; other site 465817007850 putative dimerization interface [polypeptide binding]; other site 465817007851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817007852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817007853 active site 465817007854 catalytic tetrad [active] 465817007855 putative acyltransferase; Provisional; Region: PRK05790 465817007856 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 465817007857 dimer interface [polypeptide binding]; other site 465817007858 active site 465817007859 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 465817007860 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 465817007861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007862 putative substrate translocation pore; other site 465817007863 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 465817007864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007865 motif II; other site 465817007866 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 465817007867 active site 1 [active] 465817007868 dimer interface [polypeptide binding]; other site 465817007869 hexamer interface [polypeptide binding]; other site 465817007870 active site 2 [active] 465817007871 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 465817007872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817007873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817007874 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 465817007875 substrate binding pocket [chemical binding]; other site 465817007876 dimerization interface [polypeptide binding]; other site 465817007877 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 465817007878 silverDB:etchr02403 465817007879 Phage-related protein, tail component [Function unknown]; Region: COG4723 465817007880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 465817007881 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533 465817007882 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 465817007883 active site 465817007884 metal binding site [ion binding]; metal-binding site 465817007885 interdomain interaction site; other site 465817007886 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 465817007887 ORF6N domain; Region: ORF6N; pfam10543 465817007888 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 465817007889 AntA/AntB antirepressor; Region: AntA; pfam08346 465817007890 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 465817007891 integrase; Provisional; Region: PRK09692 465817007892 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 465817007893 active site 465817007894 Int/Topo IB signature motif; other site 465817007895 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 465817007896 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 465817007897 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 465817007898 homodimer interface [polypeptide binding]; other site 465817007899 NADP binding site [chemical binding]; other site 465817007900 substrate binding site [chemical binding]; other site 465817007901 ribosome-associated protein; Provisional; Region: PRK11507 465817007902 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 465817007903 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 465817007904 NAD binding site [chemical binding]; other site 465817007905 substrate binding site [chemical binding]; other site 465817007906 catalytic Zn binding site [ion binding]; other site 465817007907 tetramer interface [polypeptide binding]; other site 465817007908 structural Zn binding site [ion binding]; other site 465817007909 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 465817007910 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 465817007911 active site 465817007912 HIGH motif; other site 465817007913 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 465817007914 KMSKS motif; other site 465817007915 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 465817007916 tRNA binding surface [nucleotide binding]; other site 465817007917 anticodon binding site; other site 465817007918 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 465817007919 substrate binding site [chemical binding]; other site 465817007920 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 465817007921 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 465817007922 putative active site [active] 465817007923 putative metal binding site [ion binding]; other site 465817007924 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 465817007925 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 465817007926 ATP-grasp domain; Region: ATP-grasp; pfam02222 465817007927 FtsX-like permease family; Region: FtsX; pfam02687 465817007928 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 465817007929 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465817007930 Walker A/P-loop; other site 465817007931 ATP binding site [chemical binding]; other site 465817007932 Q-loop/lid; other site 465817007933 ABC transporter signature motif; other site 465817007934 Walker B; other site 465817007935 D-loop; other site 465817007936 H-loop/switch region; other site 465817007937 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 465817007938 active site 465817007939 catalytic triad [active] 465817007940 oxyanion hole [active] 465817007941 switch loop; other site 465817007942 SpoVR family protein; Provisional; Region: PRK11767 465817007943 silverDB:etchr02437 465817007944 oxidoreductase; Provisional; Region: PRK08017 465817007945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817007946 NAD(P) binding site [chemical binding]; other site 465817007947 active site 465817007948 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 465817007949 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 465817007950 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 465817007951 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 465817007952 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 465817007953 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 465817007954 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 465817007955 DNA binding residues [nucleotide binding] 465817007956 dimer interface [polypeptide binding]; other site 465817007957 copper binding site [ion binding]; other site 465817007958 copper exporting ATPase; Provisional; Region: copA; PRK10671 465817007959 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465817007960 metal-binding site [ion binding] 465817007961 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465817007962 metal-binding site [ion binding] 465817007963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465817007964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817007965 motif II; other site 465817007966 TraB family; Region: TraB; cl12050 465817007967 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 465817007968 putative deacylase active site [active] 465817007969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817007970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817007971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 465817007972 dimerization interface [polypeptide binding]; other site 465817007973 Predicted membrane protein [Function unknown]; Region: COG4125 465817007974 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 465817007975 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 465817007976 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 465817007977 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 465817007978 active site 465817007979 metal binding site [ion binding]; metal-binding site 465817007980 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 465817007981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817007982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465817007983 putative substrate translocation pore; other site 465817007984 putative cation:proton antiport protein; Provisional; Region: PRK10669 465817007985 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 465817007986 TrkA-N domain; Region: TrkA_N; pfam02254 465817007987 inosine/guanosine kinase; Provisional; Region: PRK15074 465817007988 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817007989 ferrochelatase; Reviewed; Region: hemH; PRK00035 465817007990 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 465817007991 C-terminal domain interface [polypeptide binding]; other site 465817007992 active site 465817007993 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 465817007994 active site 465817007995 N-terminal domain interface [polypeptide binding]; other site 465817007996 adenylate kinase; Reviewed; Region: adk; PRK00279 465817007997 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 465817007998 AMP-binding site [chemical binding]; other site 465817007999 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 465817008000 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 465817008001 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 465817008002 nudix motif; other site 465817008003 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 465817008004 Ligand Binding Site [chemical binding]; other site 465817008005 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 465817008006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817008007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817008008 dimerization interface [polypeptide binding]; other site 465817008009 heat shock protein 90; Provisional; Region: PRK05218 465817008010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817008011 ATP binding site [chemical binding]; other site 465817008012 Mg2+ binding site [ion binding]; other site 465817008013 G-X-G motif; other site 465817008014 recombination protein RecR; Reviewed; Region: recR; PRK00076 465817008015 RecR protein; Region: RecR; pfam02132 465817008016 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 465817008017 putative active site [active] 465817008018 putative metal-binding site [ion binding]; other site 465817008019 tetramer interface [polypeptide binding]; other site 465817008020 hypothetical protein; Validated; Region: PRK00153 465817008021 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 465817008022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008023 Walker A motif; other site 465817008024 ATP binding site [chemical binding]; other site 465817008025 Walker B motif; other site 465817008026 DNA polymerase III subunit delta'; Validated; Region: PRK08485 465817008027 arginine finger; other site 465817008028 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 465817008029 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 465817008030 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 465817008031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817008032 active site 465817008033 hypothetical protein; Provisional; Region: PRK10527 465817008034 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 465817008035 hypothetical protein; Provisional; Region: PRK11038 465817008036 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 465817008037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817008038 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 465817008039 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 465817008040 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817008041 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817008042 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 465817008043 Protein export membrane protein; Region: SecD_SecF; cl14618 465817008044 Protein export membrane protein; Region: SecD_SecF; cl14618 465817008045 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 465817008046 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 465817008047 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 465817008048 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 465817008049 metal binding site [ion binding]; metal-binding site 465817008050 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 465817008051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817008052 ABC-ATPase subunit interface; other site 465817008053 dimer interface [polypeptide binding]; other site 465817008054 putative PBP binding regions; other site 465817008055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817008056 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 465817008057 Walker A/P-loop; other site 465817008058 ATP binding site [chemical binding]; other site 465817008059 Q-loop/lid; other site 465817008060 ABC transporter signature motif; other site 465817008061 Walker B; other site 465817008062 D-loop; other site 465817008063 H-loop/switch region; other site 465817008064 Hha toxicity attenuator; Provisional; Region: PRK10667 465817008065 gene expression modulator; Provisional; Region: PRK10945 465817008066 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 465817008067 DNA binding site [nucleotide binding] 465817008068 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 465817008069 active site 465817008070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 465817008071 acyl-CoA thioesterase II; Provisional; Region: PRK10526 465817008072 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 465817008073 active site 465817008074 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 465817008075 catalytic triad [active] 465817008076 dimer interface [polypeptide binding]; other site 465817008077 ammonium transporter; Provisional; Region: PRK10666 465817008078 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 465817008079 Nitrogen regulatory protein P-II; Region: P-II; smart00938 465817008080 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 465817008081 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817008082 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 465817008083 Walker A/P-loop; other site 465817008084 ATP binding site [chemical binding]; other site 465817008085 Q-loop/lid; other site 465817008086 ABC transporter signature motif; other site 465817008087 Walker B; other site 465817008088 D-loop; other site 465817008089 H-loop/switch region; other site 465817008090 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 465817008091 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817008092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817008093 Walker A/P-loop; other site 465817008094 ATP binding site [chemical binding]; other site 465817008095 Q-loop/lid; other site 465817008096 ABC transporter signature motif; other site 465817008097 Walker B; other site 465817008098 D-loop; other site 465817008099 H-loop/switch region; other site 465817008100 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 465817008101 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 465817008102 putative DNA binding site [nucleotide binding]; other site 465817008103 putative Zn2+ binding site [ion binding]; other site 465817008104 AsnC family; Region: AsnC_trans_reg; pfam01037 465817008105 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 465817008106 EamA-like transporter family; Region: EamA; pfam00892 465817008107 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 465817008108 Ligand Binding Site [chemical binding]; other site 465817008109 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 465817008110 active site 465817008111 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 465817008112 periplasmic folding chaperone; Provisional; Region: PRK10788 465817008113 SurA N-terminal domain; Region: SurA_N_3; cl07813 465817008114 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 465817008115 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 465817008116 IHF dimer interface [polypeptide binding]; other site 465817008117 IHF - DNA interface [nucleotide binding]; other site 465817008118 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 465817008119 Found in ATP-dependent protease La (LON); Region: LON; smart00464 465817008120 Found in ATP-dependent protease La (LON); Region: LON; smart00464 465817008121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008122 Walker A motif; other site 465817008123 ATP binding site [chemical binding]; other site 465817008124 Walker B motif; other site 465817008125 arginine finger; other site 465817008126 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 465817008127 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 465817008128 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 465817008129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008130 Walker A motif; other site 465817008131 ATP binding site [chemical binding]; other site 465817008132 Walker B motif; other site 465817008133 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 465817008134 Clp protease; Region: CLP_protease; pfam00574 465817008135 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 465817008136 oligomer interface [polypeptide binding]; other site 465817008137 active site residues [active] 465817008138 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 465817008139 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 465817008140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008141 Walker A motif; other site 465817008142 ATP binding site [chemical binding]; other site 465817008143 Walker B motif; other site 465817008144 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 465817008145 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 465817008146 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 465817008147 oligomer interface [polypeptide binding]; other site 465817008148 active site residues [active] 465817008149 trigger factor; Provisional; Region: tig; PRK01490 465817008150 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817008151 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 465817008152 transcriptional regulator BolA; Provisional; Region: PRK11628 465817008153 hypothetical protein; Provisional; Region: PRK11627 465817008154 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 465817008155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817008156 putative substrate translocation pore; other site 465817008157 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 465817008158 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 465817008159 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 465817008160 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 465817008161 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 465817008162 D-pathway; other site 465817008163 Putative ubiquinol binding site [chemical binding]; other site 465817008164 Low-spin heme (heme b) binding site [chemical binding]; other site 465817008165 Putative water exit pathway; other site 465817008166 Binuclear center (heme o3/CuB) [ion binding]; other site 465817008167 K-pathway; other site 465817008168 Putative proton exit pathway; other site 465817008169 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 465817008170 Subunit I/III interface [polypeptide binding]; other site 465817008171 Subunit III/IV interface [polypeptide binding]; other site 465817008172 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 465817008173 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 465817008174 UbiA prenyltransferase family; Region: UbiA; pfam01040 465817008175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817008176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 465817008177 putative substrate translocation pore; other site 465817008178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 465817008179 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 465817008180 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 465817008181 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 465817008182 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 465817008183 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 465817008184 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 465817008185 conserved cys residue [active] 465817008186 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 465817008187 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 465817008188 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 465817008189 Ligand Binding Site [chemical binding]; other site 465817008190 thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271 465817008191 active site residue [active] 465817008192 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 465817008193 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 465817008194 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 465817008195 substrate binding pocket [chemical binding]; other site 465817008196 chain length determination region; other site 465817008197 substrate-Mg2+ binding site; other site 465817008198 catalytic residues [active] 465817008199 aspartate-rich region 1; other site 465817008200 active site lid residues [active] 465817008201 aspartate-rich region 2; other site 465817008202 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 465817008203 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 465817008204 TPP-binding site; other site 465817008205 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 465817008206 PYR/PP interface [polypeptide binding]; other site 465817008207 dimer interface [polypeptide binding]; other site 465817008208 TPP binding site [chemical binding]; other site 465817008209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465817008210 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 465817008211 tetramer interfaces [polypeptide binding]; other site 465817008212 binuclear metal-binding site [ion binding]; other site 465817008213 thiamine monophosphate kinase; Provisional; Region: PRK05731 465817008214 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 465817008215 ATP binding site [chemical binding]; other site 465817008216 dimerization interface [polypeptide binding]; other site 465817008217 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 465817008218 putative RNA binding site [nucleotide binding]; other site 465817008219 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 465817008220 homopentamer interface [polypeptide binding]; other site 465817008221 active site 465817008222 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 465817008223 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 465817008224 catalytic motif [active] 465817008225 Zn binding site [ion binding]; other site 465817008226 RibD C-terminal domain; Region: RibD_C; cl17279 465817008227 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 465817008228 ATP cone domain; Region: ATP-cone; pfam03477 465817008229 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 465817008230 BON domain; Region: BON; pfam04972 465817008231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817008232 hypothetical protein; Provisional; Region: PRK11530 465817008233 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 465817008234 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 465817008235 Protein export membrane protein; Region: SecD_SecF; pfam02355 465817008236 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 465817008237 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 465817008238 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 465817008239 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 465817008240 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 465817008241 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 465817008242 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 465817008243 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 465817008244 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 465817008245 Protein of unknown function, DUF479; Region: DUF479; cl01203 465817008246 peroxidase; Provisional; Region: PRK15000 465817008247 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 465817008248 dimer interface [polypeptide binding]; other site 465817008249 decamer (pentamer of dimers) interface [polypeptide binding]; other site 465817008250 catalytic triad [active] 465817008251 peroxidatic and resolving cysteines [active] 465817008252 putative proline-specific permease; Provisional; Region: proY; PRK10580 465817008253 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 465817008254 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 465817008255 substrate binding site [chemical binding]; other site 465817008256 THF binding site; other site 465817008257 zinc-binding site [ion binding]; other site 465817008258 PBP superfamily domain; Region: PBP_like_2; cl17296 465817008259 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 465817008260 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 465817008261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817008262 putative active site [active] 465817008263 heme pocket [chemical binding]; other site 465817008264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817008265 dimer interface [polypeptide binding]; other site 465817008266 phosphorylation site [posttranslational modification] 465817008267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817008268 ATP binding site [chemical binding]; other site 465817008269 Mg2+ binding site [ion binding]; other site 465817008270 G-X-G motif; other site 465817008271 transcriptional regulator PhoB; Provisional; Region: PRK10161 465817008272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817008273 active site 465817008274 phosphorylation site [posttranslational modification] 465817008275 intermolecular recognition site; other site 465817008276 dimerization interface [polypeptide binding]; other site 465817008277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817008278 DNA binding site [nucleotide binding] 465817008279 exonuclease subunit SbcD; Provisional; Region: PRK10966 465817008280 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 465817008281 active site 465817008282 metal binding site [ion binding]; metal-binding site 465817008283 DNA binding site [nucleotide binding] 465817008284 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 465817008285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817008286 AAA domain; Region: AAA_23; pfam13476 465817008287 Walker A/P-loop; other site 465817008288 ATP binding site [chemical binding]; other site 465817008289 Q-loop/lid; other site 465817008290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817008291 ABC transporter signature motif; other site 465817008292 Walker B; other site 465817008293 D-loop; other site 465817008294 H-loop/switch region; other site 465817008295 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 465817008296 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 465817008297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817008298 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 465817008299 active site 465817008300 substrate binding site [chemical binding]; other site 465817008301 Phosphotransferase enzyme family; Region: APH; pfam01636 465817008302 ATP binding site [chemical binding]; other site 465817008303 ethanolamine permease; Region: 2A0305; TIGR00908 465817008304 recombination associated protein; Reviewed; Region: rdgC; PRK00321 465817008305 hypothetical protein; Provisional; Region: PRK10579 465817008306 hypothetical protein; Provisional; Region: PRK10481 465817008307 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 465817008308 OPT oligopeptide transporter protein; Region: OPT; cl14607 465817008309 Transcriptional regulator [Transcription]; Region: IclR; COG1414 465817008310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465817008311 putative DNA binding site [nucleotide binding]; other site 465817008312 putative Zn2+ binding site [ion binding]; other site 465817008313 Bacterial transcriptional regulator; Region: IclR; pfam01614 465817008314 hypothetical protein; Provisional; Region: PRK10380 465817008315 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 465817008316 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 465817008317 ADP binding site [chemical binding]; other site 465817008318 magnesium binding site [ion binding]; other site 465817008319 putative shikimate binding site; other site 465817008320 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 465817008321 hypothetical protein; Validated; Region: PRK00124 465817008322 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 465817008323 pyrroline-5-carboxylate reductase; Region: PLN02688 465817008324 hypothetical protein; Provisional; Region: PRK11505 465817008325 psiF repeat; Region: PsiF_repeat; pfam07769 465817008326 psiF repeat; Region: PsiF_repeat; pfam07769 465817008327 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 465817008328 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 465817008329 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 465817008330 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 465817008331 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 465817008332 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 465817008333 DNA-binding site [nucleotide binding]; DNA binding site 465817008334 RNA-binding motif; other site 465817008335 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 465817008336 CAAX protease self-immunity; Region: Abi; pfam02517 465817008337 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817008338 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 465817008339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465817008340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817008341 dimer interface [polypeptide binding]; other site 465817008342 conserved gate region; other site 465817008343 putative PBP binding loops; other site 465817008344 ABC-ATPase subunit interface; other site 465817008345 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 465817008346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817008347 dimer interface [polypeptide binding]; other site 465817008348 conserved gate region; other site 465817008349 putative PBP binding loops; other site 465817008350 ABC-ATPase subunit interface; other site 465817008351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 465817008352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817008353 Walker A/P-loop; other site 465817008354 ATP binding site [chemical binding]; other site 465817008355 Q-loop/lid; other site 465817008356 ABC transporter signature motif; other site 465817008357 Walker B; other site 465817008358 D-loop; other site 465817008359 H-loop/switch region; other site 465817008360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817008361 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 465817008362 Walker A/P-loop; other site 465817008363 ATP binding site [chemical binding]; other site 465817008364 Q-loop/lid; other site 465817008365 ABC transporter signature motif; other site 465817008366 Walker B; other site 465817008367 D-loop; other site 465817008368 H-loop/switch region; other site 465817008369 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817008370 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 465817008371 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817008372 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 465817008373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817008374 S-adenosylmethionine binding site [chemical binding]; other site 465817008375 anti-RssB factor; Provisional; Region: PRK10244 465817008376 chromosome condensation membrane protein; Provisional; Region: PRK14196 465817008377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 465817008378 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 465817008379 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 465817008380 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 465817008381 shikimate binding site; other site 465817008382 NAD(P) binding site [chemical binding]; other site 465817008383 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 465817008384 homodimer interface [polypeptide binding]; other site 465817008385 putative active site [active] 465817008386 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817008387 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 465817008388 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 465817008389 putative catalytic cysteine [active] 465817008390 gamma-glutamyl kinase; Provisional; Region: PRK05429 465817008391 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 465817008392 nucleotide binding site [chemical binding]; other site 465817008393 homotetrameric interface [polypeptide binding]; other site 465817008394 putative phosphate binding site [ion binding]; other site 465817008395 putative allosteric binding site; other site 465817008396 PUA domain; Region: PUA; pfam01472 465817008397 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 465817008398 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 465817008399 trimer interface [polypeptide binding]; other site 465817008400 eyelet of channel; other site 465817008401 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 465817008402 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 465817008403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817008404 active site 465817008405 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 465817008406 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 465817008407 metal binding site [ion binding]; metal-binding site 465817008408 dimer interface [polypeptide binding]; other site 465817008409 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 465817008410 active site 465817008411 DNA polymerase IV; Validated; Region: PRK02406 465817008412 DNA binding site [nucleotide binding] 465817008413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 465817008414 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 465817008415 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 465817008416 putative active site [active] 465817008417 putative dimer interface [polypeptide binding]; other site 465817008418 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 465817008419 dimer interface [polypeptide binding]; other site 465817008420 active site 465817008421 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 465817008422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 465817008423 active site 465817008424 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 465817008425 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 465817008426 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 465817008427 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 465817008428 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 465817008429 Cupin domain; Region: Cupin_2; cl17218 465817008430 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 465817008431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817008432 motif II; other site 465817008433 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 465817008434 intersubunit interface [polypeptide binding]; other site 465817008435 active site 465817008436 Zn2+ binding site [ion binding]; other site 465817008437 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 465817008438 methionine aminotransferase; Validated; Region: PRK09082 465817008439 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817008440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817008441 homodimer interface [polypeptide binding]; other site 465817008442 catalytic residue [active] 465817008443 C-N hydrolase family amidase; Provisional; Region: PRK10438 465817008444 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 465817008445 active site 465817008446 catalytic triad [active] 465817008447 dimer interface [polypeptide binding]; other site 465817008448 xanthine permease; Region: pbuX; TIGR03173 465817008449 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 465817008450 active site 465817008451 homotetramer interface [polypeptide binding]; other site 465817008452 OHCU decarboxylase; Region: UraD_2; TIGR03180 465817008453 allantoate amidohydrolase; Reviewed; Region: PRK09290 465817008454 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 465817008455 active site 465817008456 metal binding site [ion binding]; metal-binding site 465817008457 dimer interface [polypeptide binding]; other site 465817008458 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 465817008459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817008460 catalytic residue [active] 465817008461 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817008462 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817008463 Walker A/P-loop; other site 465817008464 ATP binding site [chemical binding]; other site 465817008465 Q-loop/lid; other site 465817008466 ABC transporter signature motif; other site 465817008467 Walker B; other site 465817008468 D-loop; other site 465817008469 H-loop/switch region; other site 465817008470 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817008471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817008472 dimer interface [polypeptide binding]; other site 465817008473 conserved gate region; other site 465817008474 putative PBP binding loops; other site 465817008475 ABC-ATPase subunit interface; other site 465817008476 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 465817008477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817008478 dimer interface [polypeptide binding]; other site 465817008479 conserved gate region; other site 465817008480 putative PBP binding loops; other site 465817008481 ABC-ATPase subunit interface; other site 465817008482 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465817008483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817008484 substrate binding pocket [chemical binding]; other site 465817008485 membrane-bound complex binding site; other site 465817008486 hinge residues; other site 465817008487 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 465817008488 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 465817008489 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 465817008490 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 465817008491 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 465817008492 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 465817008493 amidase; Provisional; Region: PRK09201 465817008494 Amidase; Region: Amidase; cl11426 465817008495 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 465817008496 Uncharacterized conserved protein [Function unknown]; Region: COG4127 465817008497 Restriction endonuclease; Region: Mrr_cat; pfam04471 465817008498 silverDB:etchr02617 465817008499 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 465817008500 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 465817008501 active site 465817008502 catalytic site [active] 465817008503 tetramer interface [polypeptide binding]; other site 465817008504 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 465817008505 Transcriptional regulators [Transcription]; Region: GntR; COG1802 465817008506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 465817008507 DNA-binding site [nucleotide binding]; DNA binding site 465817008508 FCD domain; Region: FCD; pfam07729 465817008509 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 465817008510 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 465817008511 Na binding site [ion binding]; other site 465817008512 putative substrate binding site [chemical binding]; other site 465817008513 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 465817008514 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 465817008515 active site 465817008516 catalytic site [active] 465817008517 substrate binding site [chemical binding]; other site 465817008518 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 465817008519 RNA/DNA hybrid binding site [nucleotide binding]; other site 465817008520 active site 465817008521 Methyltransferase domain; Region: Methyltransf_11; pfam08241 465817008522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 465817008523 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 465817008524 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817008525 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817008526 catalytic residue [active] 465817008527 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817008528 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817008529 silverDB:etchr02628 465817008530 hypothetical protein; Provisional; Region: PRK05421 465817008531 putative catalytic site [active] 465817008532 putative metal binding site [ion binding]; other site 465817008533 putative phosphate binding site [ion binding]; other site 465817008534 putative catalytic site [active] 465817008535 putative phosphate binding site [ion binding]; other site 465817008536 putative metal binding site [ion binding]; other site 465817008537 protein disaggregation chaperone; Provisional; Region: PRK10865 465817008538 Clp amino terminal domain; Region: Clp_N; pfam02861 465817008539 Clp amino terminal domain; Region: Clp_N; pfam02861 465817008540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008541 Walker A motif; other site 465817008542 ATP binding site [chemical binding]; other site 465817008543 Walker B motif; other site 465817008544 arginine finger; other site 465817008545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817008546 Walker A motif; other site 465817008547 ATP binding site [chemical binding]; other site 465817008548 Walker B motif; other site 465817008549 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 465817008550 hypothetical protein; Provisional; Region: PRK10723 465817008551 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 465817008552 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 465817008553 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817008554 RNA binding surface [nucleotide binding]; other site 465817008555 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 465817008556 active site 465817008557 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 465817008558 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 465817008559 30S subunit binding site; other site 465817008560 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 465817008561 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 465817008562 Prephenate dehydratase; Region: PDT; pfam00800 465817008563 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 465817008564 putative L-Phe binding site [chemical binding]; other site 465817008565 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 465817008566 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 465817008567 prephenate dehydrogenase; Validated; Region: PRK08507 465817008568 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 465817008569 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 465817008570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 465817008571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 465817008572 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 465817008573 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 465817008574 hypothetical protein; Validated; Region: PRK06186 465817008575 conserved cys residue [active] 465817008576 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 465817008577 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 465817008578 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 465817008579 RimM N-terminal domain; Region: RimM; pfam01782 465817008580 PRC-barrel domain; Region: PRC; pfam05239 465817008581 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 465817008582 signal recognition particle protein; Provisional; Region: PRK10867 465817008583 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 465817008584 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 465817008585 P loop; other site 465817008586 GTP binding site [chemical binding]; other site 465817008587 Signal peptide binding domain; Region: SRP_SPB; pfam02978 465817008588 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 465817008589 hypothetical protein; Provisional; Region: PRK11573 465817008590 Domain of unknown function DUF21; Region: DUF21; pfam01595 465817008591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465817008592 Transporter associated domain; Region: CorC_HlyC; smart01091 465817008593 S-ribosylhomocysteinase; Provisional; Region: PRK02260 465817008594 glutamate--cysteine ligase; Provisional; Region: PRK02107 465817008595 Predicted membrane protein [Function unknown]; Region: COG1238 465817008596 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 465817008597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817008598 motif II; other site 465817008599 carbon storage regulator; Provisional; Region: PRK01712 465817008600 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 465817008601 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 465817008602 motif 1; other site 465817008603 active site 465817008604 motif 2; other site 465817008605 motif 3; other site 465817008606 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 465817008607 DHHA1 domain; Region: DHHA1; pfam02272 465817008608 recombination regulator RecX; Reviewed; Region: recX; PRK00117 465817008609 recombinase A; Provisional; Region: recA; PRK09354 465817008610 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 465817008611 hexamer interface [polypeptide binding]; other site 465817008612 Walker A motif; other site 465817008613 ATP binding site [chemical binding]; other site 465817008614 Walker B motif; other site 465817008615 hypothetical protein; Validated; Region: PRK03661 465817008616 Transglycosylase SLT domain; Region: SLT_2; pfam13406 465817008617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817008618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817008619 catalytic residue [active] 465817008620 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 465817008621 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 465817008622 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 465817008623 catalytic residues [active] 465817008624 hinge region; other site 465817008625 alpha helical domain; other site 465817008626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817008627 DNA binding site [nucleotide binding] 465817008628 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 465817008629 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 465817008630 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 465817008631 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 465817008632 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 465817008633 Tetratricopeptide repeat; Region: TPR_3; pfam07720 465817008634 Tetratricopeptide repeat; Region: TPR_3; pfam07720 465817008635 type III secretion system protein SpaS; Validated; Region: PRK08156 465817008636 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 465817008637 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 465817008638 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 465817008639 type III secretion system protein SpaO; Validated; Region: PRK08158 465817008640 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 465817008641 silverDB:etchr02677 465817008642 silverDB:etchr02678 465817008643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465817008644 Transposase; Region: HTH_Tnp_1; pfam01527 465817008645 putative transposase OrfB; Reviewed; Region: PHA02517 465817008646 HTH-like domain; Region: HTH_21; pfam13276 465817008647 Integrase core domain; Region: rve; pfam00665 465817008648 Integrase core domain; Region: rve_3; pfam13683 465817008649 silverDB:etchr02681 465817008650 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 465817008651 MutS domain I; Region: MutS_I; pfam01624 465817008652 MutS domain II; Region: MutS_II; pfam05188 465817008653 MutS domain III; Region: MutS_III; pfam05192 465817008654 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 465817008655 Walker A/P-loop; other site 465817008656 ATP binding site [chemical binding]; other site 465817008657 Q-loop/lid; other site 465817008658 ABC transporter signature motif; other site 465817008659 Walker B; other site 465817008660 D-loop; other site 465817008661 H-loop/switch region; other site 465817008662 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 465817008663 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 465817008664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817008665 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 465817008666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817008667 DNA binding residues [nucleotide binding] 465817008668 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 465817008669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817008670 Peptidase family M23; Region: Peptidase_M23; pfam01551 465817008671 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 465817008672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817008673 S-adenosylmethionine binding site [chemical binding]; other site 465817008674 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 465817008675 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 465817008676 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 465817008677 Permutation of conserved domain; other site 465817008678 active site 465817008679 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 465817008680 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 465817008681 homotrimer interaction site [polypeptide binding]; other site 465817008682 zinc binding site [ion binding]; other site 465817008683 CDP-binding sites; other site 465817008684 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 465817008685 substrate binding site; other site 465817008686 dimer interface; other site 465817008687 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 465817008688 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 465817008689 hypothetical protein; Provisional; Region: PRK10726 465817008690 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 465817008691 ligand-binding site [chemical binding]; other site 465817008692 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 465817008693 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 465817008694 CysD dimerization site [polypeptide binding]; other site 465817008695 G1 box; other site 465817008696 putative GEF interaction site [polypeptide binding]; other site 465817008697 GTP/Mg2+ binding site [chemical binding]; other site 465817008698 Switch I region; other site 465817008699 G2 box; other site 465817008700 G3 box; other site 465817008701 Switch II region; other site 465817008702 G4 box; other site 465817008703 G5 box; other site 465817008704 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 465817008705 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 465817008706 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 465817008707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 465817008708 Active Sites [active] 465817008709 siroheme synthase; Provisional; Region: cysG; PRK10637 465817008710 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 465817008711 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 465817008712 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 465817008713 active site 465817008714 SAM binding site [chemical binding]; other site 465817008715 homodimer interface [polypeptide binding]; other site 465817008716 YCII-related domain; Region: YCII; cl00999 465817008717 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 465817008718 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 465817008719 Active Sites [active] 465817008720 sulfite reductase subunit beta; Provisional; Region: PRK13504 465817008721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 465817008722 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 465817008723 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 465817008724 Flavodoxin; Region: Flavodoxin_1; pfam00258 465817008725 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 465817008726 FAD binding pocket [chemical binding]; other site 465817008727 FAD binding motif [chemical binding]; other site 465817008728 catalytic residues [active] 465817008729 NAD binding pocket [chemical binding]; other site 465817008730 phosphate binding motif [ion binding]; other site 465817008731 beta-alpha-beta structure motif; other site 465817008732 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 465817008733 active site 465817008734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817008735 dimer interface [polypeptide binding]; other site 465817008736 conserved gate region; other site 465817008737 putative PBP binding loops; other site 465817008738 ABC-ATPase subunit interface; other site 465817008739 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 465817008740 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 465817008741 Walker A/P-loop; other site 465817008742 ATP binding site [chemical binding]; other site 465817008743 Q-loop/lid; other site 465817008744 ABC transporter signature motif; other site 465817008745 Walker B; other site 465817008746 D-loop; other site 465817008747 H-loop/switch region; other site 465817008748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 465817008749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817008750 substrate binding pocket [chemical binding]; other site 465817008751 membrane-bound complex binding site; other site 465817008752 hinge residues; other site 465817008753 transcriptional activator TtdR; Provisional; Region: PRK09801 465817008754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817008755 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817008756 putative effector binding pocket; other site 465817008757 dimerization interface [polypeptide binding]; other site 465817008758 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 465817008759 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 465817008760 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 465817008761 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 465817008762 enolase; Provisional; Region: eno; PRK00077 465817008763 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 465817008764 dimer interface [polypeptide binding]; other site 465817008765 metal binding site [ion binding]; metal-binding site 465817008766 substrate binding pocket [chemical binding]; other site 465817008767 CTP synthetase; Validated; Region: pyrG; PRK05380 465817008768 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 465817008769 Catalytic site [active] 465817008770 active site 465817008771 UTP binding site [chemical binding]; other site 465817008772 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 465817008773 active site 465817008774 putative oxyanion hole; other site 465817008775 catalytic triad [active] 465817008776 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 465817008777 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 465817008778 homodimer interface [polypeptide binding]; other site 465817008779 metal binding site [ion binding]; metal-binding site 465817008780 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 465817008781 homodimer interface [polypeptide binding]; other site 465817008782 active site 465817008783 putative chemical substrate binding site [chemical binding]; other site 465817008784 metal binding site [ion binding]; metal-binding site 465817008785 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 465817008786 HD domain; Region: HD_4; pfam13328 465817008787 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 465817008788 synthetase active site [active] 465817008789 NTP binding site [chemical binding]; other site 465817008790 metal binding site [ion binding]; metal-binding site 465817008791 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 465817008792 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 465817008793 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 465817008794 TRAM domain; Region: TRAM; pfam01938 465817008795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817008796 S-adenosylmethionine binding site [chemical binding]; other site 465817008797 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 465817008798 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 465817008799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817008800 dimerization interface [polypeptide binding]; other site 465817008801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817008802 dimer interface [polypeptide binding]; other site 465817008803 phosphorylation site [posttranslational modification] 465817008804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817008805 ATP binding site [chemical binding]; other site 465817008806 Mg2+ binding site [ion binding]; other site 465817008807 G-X-G motif; other site 465817008808 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 465817008809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817008810 active site 465817008811 phosphorylation site [posttranslational modification] 465817008812 intermolecular recognition site; other site 465817008813 dimerization interface [polypeptide binding]; other site 465817008814 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 465817008815 putative binding surface; other site 465817008816 active site 465817008817 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 465817008818 flavodoxin; Provisional; Region: PRK08105 465817008819 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 465817008820 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 465817008821 probable active site [active] 465817008822 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 465817008823 SecY interacting protein Syd; Provisional; Region: PRK04968 465817008824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 465817008825 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 465817008826 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 465817008827 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 465817008828 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 465817008829 flap endonuclease-like protein; Provisional; Region: PRK09482 465817008830 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 465817008831 active site 465817008832 metal binding site 1 [ion binding]; metal-binding site 465817008833 putative 5' ssDNA interaction site; other site 465817008834 metal binding site 3; metal-binding site 465817008835 metal binding site 2 [ion binding]; metal-binding site 465817008836 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 465817008837 putative DNA binding site [nucleotide binding]; other site 465817008838 putative metal binding site [ion binding]; other site 465817008839 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 465817008840 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 465817008841 hypothetical protein; Provisional; Region: PRK10873 465817008842 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 465817008843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817008844 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 465817008845 dimerization interface [polypeptide binding]; other site 465817008846 substrate binding pocket [chemical binding]; other site 465817008847 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 465817008848 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 465817008849 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 465817008850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817008851 catalytic residue [active] 465817008852 Fe-S metabolism associated domain; Region: SufE; cl00951 465817008853 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 465817008854 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 465817008855 putative ATP binding site [chemical binding]; other site 465817008856 putative substrate interface [chemical binding]; other site 465817008857 murein transglycosylase A; Provisional; Region: mltA; PRK11162 465817008858 MltA specific insert domain; Region: MltA; pfam03562 465817008859 3D domain; Region: 3D; pfam06725 465817008860 AMIN domain; Region: AMIN; pfam11741 465817008861 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 465817008862 active site 465817008863 metal binding site [ion binding]; metal-binding site 465817008864 N-acetylglutamate synthase; Validated; Region: PRK05279 465817008865 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 465817008866 putative feedback inhibition sensing region; other site 465817008867 putative nucleotide binding site [chemical binding]; other site 465817008868 putative substrate binding site [chemical binding]; other site 465817008869 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 465817008870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817008871 Coenzyme A binding pocket [chemical binding]; other site 465817008872 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 465817008873 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 465817008874 AAA domain; Region: AAA_30; pfam13604 465817008875 Family description; Region: UvrD_C_2; pfam13538 465817008876 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 465817008877 protease3; Provisional; Region: PRK15101 465817008878 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 465817008879 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 465817008880 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 465817008881 allantoate amidohydrolase; Reviewed; Region: PRK12893 465817008882 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 465817008883 active site 465817008884 metal binding site [ion binding]; metal-binding site 465817008885 dimer interface [polypeptide binding]; other site 465817008886 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 465817008887 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 465817008888 dimer interface [polypeptide binding]; other site 465817008889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817008890 catalytic residue [active] 465817008891 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 465817008892 EamA-like transporter family; Region: EamA; pfam00892 465817008893 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 465817008894 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 465817008895 active site 465817008896 Mn binding site [ion binding]; other site 465817008897 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 465817008898 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 465817008899 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 465817008900 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 465817008901 hypothetical protein; Provisional; Region: PRK10557 465817008902 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 465817008903 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 465817008904 hypothetical protein; Provisional; Region: PRK10506 465817008905 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 465817008906 thymidylate synthase; Reviewed; Region: thyA; PRK01827 465817008907 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 465817008908 dimerization interface [polypeptide binding]; other site 465817008909 active site 465817008910 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 465817008911 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 465817008912 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 465817008913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 465817008914 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 465817008915 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 465817008916 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 465817008917 putative active site [active] 465817008918 Ap4A binding site [chemical binding]; other site 465817008919 nudix motif; other site 465817008920 putative metal binding site [ion binding]; other site 465817008921 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 465817008922 putative DNA-binding cleft [nucleotide binding]; other site 465817008923 putative DNA clevage site; other site 465817008924 molecular lever; other site 465817008925 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 465817008926 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 465817008927 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 465817008928 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 465817008929 active site 465817008930 catalytic tetrad [active] 465817008931 lysophospholipid transporter LplT; Provisional; Region: PRK11195 465817008932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817008933 putative substrate translocation pore; other site 465817008934 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 465817008935 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 465817008936 putative acyl-acceptor binding pocket; other site 465817008937 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 465817008938 acyl-activating enzyme (AAE) consensus motif; other site 465817008939 putative AMP binding site [chemical binding]; other site 465817008940 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 465817008941 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 465817008942 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 465817008943 Protein export membrane protein; Region: SecD_SecF; cl14618 465817008944 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 465817008945 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 465817008946 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817008947 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 465817008948 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 465817008949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 465817008950 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 465817008951 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 465817008952 molybdopterin cofactor binding site [chemical binding]; other site 465817008953 substrate binding site [chemical binding]; other site 465817008954 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 465817008955 molybdopterin cofactor binding site; other site 465817008956 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 465817008957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817008958 DNA binding site [nucleotide binding] 465817008959 domain linker motif; other site 465817008960 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 465817008961 dimerization interface (closed form) [polypeptide binding]; other site 465817008962 ligand binding site [chemical binding]; other site 465817008963 diaminopimelate decarboxylase; Provisional; Region: PRK11165 465817008964 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 465817008965 active site 465817008966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465817008967 substrate binding site [chemical binding]; other site 465817008968 catalytic residues [active] 465817008969 dimer interface [polypeptide binding]; other site 465817008970 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 465817008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817008972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817008973 dimerization interface [polypeptide binding]; other site 465817008974 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 465817008975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817008976 putative substrate translocation pore; other site 465817008977 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 465817008978 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 465817008979 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 465817008980 dimer interface [polypeptide binding]; other site 465817008981 putative anticodon binding site; other site 465817008982 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 465817008983 motif 1; other site 465817008984 active site 465817008985 motif 2; other site 465817008986 motif 3; other site 465817008987 peptide chain release factor 2; Provisional; Region: PRK08787 465817008988 This domain is found in peptide chain release factors; Region: PCRF; smart00937 465817008989 RF-1 domain; Region: RF-1; pfam00472 465817008990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817008991 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 465817008992 DHH family; Region: DHH; pfam01368 465817008993 DHHA1 domain; Region: DHHA1; pfam02272 465817008994 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 465817008995 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 465817008996 dimerization domain [polypeptide binding]; other site 465817008997 dimer interface [polypeptide binding]; other site 465817008998 catalytic residues [active] 465817008999 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 465817009000 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 465817009001 active site 465817009002 Int/Topo IB signature motif; other site 465817009003 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 465817009004 EamA-like transporter family; Region: EamA; pfam00892 465817009005 flavodoxin FldB; Provisional; Region: PRK12359 465817009006 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 465817009007 hypothetical protein; Provisional; Region: PRK10878 465817009008 putative global regulator; Reviewed; Region: PRK09559 465817009009 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 465817009010 hemolysin; Provisional; Region: PRK15087 465817009011 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 465817009012 HD domain; Region: HD_3; pfam13023 465817009013 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 465817009014 classical (c) SDRs; Region: SDR_c; cd05233 465817009015 NAD(P) binding site [chemical binding]; other site 465817009016 active site 465817009017 glycine dehydrogenase; Provisional; Region: PRK05367 465817009018 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 465817009019 tetramer interface [polypeptide binding]; other site 465817009020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009021 catalytic residue [active] 465817009022 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 465817009023 tetramer interface [polypeptide binding]; other site 465817009024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009025 catalytic residue [active] 465817009026 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 465817009027 lipoyl attachment site [posttranslational modification]; other site 465817009028 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 465817009029 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 465817009030 Abi-like protein; Region: Abi_2; pfam07751 465817009031 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 465817009032 oxidoreductase; Provisional; Region: PRK08013 465817009033 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 465817009034 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 465817009035 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 465817009036 proline aminopeptidase P II; Provisional; Region: PRK10879 465817009037 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 465817009038 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 465817009039 active site 465817009040 hypothetical protein; Reviewed; Region: PRK01736 465817009041 Z-ring-associated protein; Provisional; Region: PRK10972 465817009042 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 465817009043 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 465817009044 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 465817009045 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 465817009046 ligand binding site [chemical binding]; other site 465817009047 NAD binding site [chemical binding]; other site 465817009048 tetramer interface [polypeptide binding]; other site 465817009049 catalytic site [active] 465817009050 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 465817009051 L-serine binding site [chemical binding]; other site 465817009052 ACT domain interface; other site 465817009053 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 465817009054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465817009055 active site 465817009056 dimer interface [polypeptide binding]; other site 465817009057 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 465817009058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817009059 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 465817009060 putative dimerization interface [polypeptide binding]; other site 465817009061 oxidative stress defense protein; Provisional; Region: PRK11087 465817009062 Uncharacterized conserved protein [Function unknown]; Region: COG2968 465817009063 LysE type translocator; Region: LysE; cl00565 465817009064 mechanosensitive channel MscS; Provisional; Region: PRK10334 465817009065 Conserved TM helix; Region: TM_helix; pfam05552 465817009066 Mechanosensitive ion channel; Region: MS_channel; pfam00924 465817009067 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 465817009068 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 465817009069 active site 465817009070 intersubunit interface [polypeptide binding]; other site 465817009071 zinc binding site [ion binding]; other site 465817009072 Na+ binding site [ion binding]; other site 465817009073 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 465817009074 Phosphoglycerate kinase; Region: PGK; pfam00162 465817009075 substrate binding site [chemical binding]; other site 465817009076 hinge regions; other site 465817009077 ADP binding site [chemical binding]; other site 465817009078 catalytic site [active] 465817009079 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 465817009080 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 465817009081 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 465817009082 transketolase; Reviewed; Region: PRK12753 465817009083 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 465817009084 TPP-binding site [chemical binding]; other site 465817009085 dimer interface [polypeptide binding]; other site 465817009086 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 465817009087 PYR/PP interface [polypeptide binding]; other site 465817009088 dimer interface [polypeptide binding]; other site 465817009089 TPP binding site [chemical binding]; other site 465817009090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 465817009091 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 465817009092 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817009093 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 465817009094 substrate binding pocket [chemical binding]; other site 465817009095 active site 465817009096 iron coordination sites [ion binding]; other site 465817009097 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 465817009098 putative active site [active] 465817009099 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 465817009100 agmatinase; Region: agmatinase; TIGR01230 465817009101 oligomer interface [polypeptide binding]; other site 465817009102 putative active site [active] 465817009103 Mn binding site [ion binding]; other site 465817009104 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 465817009105 arginine decarboxylase; Provisional; Region: PRK05354 465817009106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 465817009107 dimer interface [polypeptide binding]; other site 465817009108 active site 465817009109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465817009110 catalytic residues [active] 465817009111 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 465817009112 S-adenosylmethionine synthetase; Validated; Region: PRK05250 465817009113 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 465817009114 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 465817009115 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 465817009116 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 465817009117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817009118 putative substrate translocation pore; other site 465817009119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817009120 hypothetical protein; Provisional; Region: PRK04860 465817009121 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 465817009122 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 465817009123 DNA-specific endonuclease I; Provisional; Region: PRK15137 465817009124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 465817009125 RNA methyltransferase, RsmE family; Region: TIGR00046 465817009126 glutathione synthetase; Provisional; Region: PRK05246 465817009127 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 465817009128 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 465817009129 hypothetical protein; Validated; Region: PRK00228 465817009130 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 465817009131 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 465817009132 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 465817009133 catalytic triad [active] 465817009134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 465817009135 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 465817009136 DsbD alpha interface [polypeptide binding]; other site 465817009137 catalytic residues [active] 465817009138 RNA polymerase sigma factor; Provisional; Region: PRK12512 465817009139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817009140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817009141 DNA binding residues [nucleotide binding] 465817009142 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 465817009143 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817009144 Walker A motif; other site 465817009145 ATP binding site [chemical binding]; other site 465817009146 Walker B motif; other site 465817009147 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 465817009148 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 465817009149 catalytic residue [active] 465817009150 YGGT family; Region: YGGT; pfam02325 465817009151 YGGT family; Region: YGGT; pfam02325 465817009152 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 465817009153 active site 465817009154 dimerization interface [polypeptide binding]; other site 465817009155 HemN family oxidoreductase; Provisional; Region: PRK05660 465817009156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817009157 FeS/SAM binding site; other site 465817009158 HemN C-terminal domain; Region: HemN_C; pfam06969 465817009159 hypothetical protein; Provisional; Region: PRK10626 465817009160 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 465817009161 hypothetical protein; Provisional; Region: PRK11702 465817009162 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 465817009163 adenine DNA glycosylase; Provisional; Region: PRK10880 465817009164 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 465817009165 minor groove reading motif; other site 465817009166 helix-hairpin-helix signature motif; other site 465817009167 substrate binding pocket [chemical binding]; other site 465817009168 active site 465817009169 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 465817009170 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 465817009171 DNA binding and oxoG recognition site [nucleotide binding] 465817009172 oxidative damage protection protein; Provisional; Region: PRK05408 465817009173 murein transglycosylase C; Provisional; Region: mltC; PRK11671 465817009174 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 465817009175 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 465817009176 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817009177 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817009178 catalytic residue [active] 465817009179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 465817009180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817009181 ornithine decarboxylase; Provisional; Region: PRK13578 465817009182 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 465817009183 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 465817009184 homodimer interface [polypeptide binding]; other site 465817009185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009186 catalytic residue [active] 465817009187 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 465817009188 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009189 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817009190 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817009191 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817009192 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 465817009193 PapC N-terminal domain; Region: PapC_N; pfam13954 465817009194 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817009195 PapC C-terminal domain; Region: PapC_C; pfam13953 465817009196 Fimbrial protein; Region: Fimbrial; cl01416 465817009197 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817009198 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817009199 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817009200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817009201 DNA binding residues [nucleotide binding] 465817009202 dimerization interface [polypeptide binding]; other site 465817009203 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 465817009204 silverDB:etchr02847 465817009205 Transposase; Region: HTH_Tnp_1; pfam01527 465817009206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817009207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817009208 DNA binding residues [nucleotide binding] 465817009209 dimerization interface [polypeptide binding]; other site 465817009210 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 465817009211 mannosyl binding site [chemical binding]; other site 465817009212 Fimbrial protein; Region: Fimbrial; cl01416 465817009213 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009214 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009215 outer membrane usher protein; Provisional; Region: PRK15193 465817009216 PapC N-terminal domain; Region: PapC_N; pfam13954 465817009217 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817009218 PapC C-terminal domain; Region: PapC_C; pfam13953 465817009219 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817009220 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817009221 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009222 Fimbrial protein; Region: Fimbrial; cl01416 465817009223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465817009224 active site 465817009225 DNA binding site [nucleotide binding] 465817009226 Int/Topo IB signature motif; other site 465817009227 silverDB:etchr02859 465817009228 Predicted membrane protein [Function unknown]; Region: COG2259 465817009229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 465817009230 Integrase core domain; Region: rve; pfam00665 465817009231 outer membrane usher protein; Provisional; Region: PRK15193 465817009232 PapC N-terminal domain; Region: PapC_N; pfam13954 465817009233 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817009234 PapC C-terminal domain; Region: PapC_C; pfam13953 465817009235 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 465817009236 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817009237 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817009238 Fimbrial protein; Region: Fimbrial; cl01416 465817009239 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 465817009240 dimer interface [polypeptide binding]; other site 465817009241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 465817009242 ligand binding site [chemical binding]; other site 465817009243 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 465817009244 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 465817009245 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 465817009246 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 465817009247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817009248 FeS/SAM binding site; other site 465817009249 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 465817009250 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 465817009251 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 465817009252 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 465817009253 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 465817009254 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 465817009255 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 465817009256 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 465817009257 active site 465817009258 dimer interface [polypeptide binding]; other site 465817009259 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 465817009260 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 465817009261 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 465817009262 Sulfate transporter family; Region: Sulfate_transp; pfam00916 465817009263 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 465817009264 active site clefts [active] 465817009265 zinc binding site [ion binding]; other site 465817009266 dimer interface [polypeptide binding]; other site 465817009267 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 465817009268 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 465817009269 NADP binding site [chemical binding]; other site 465817009270 homodimer interface [polypeptide binding]; other site 465817009271 active site 465817009272 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465817009273 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 465817009274 active site 465817009275 FMN binding site [chemical binding]; other site 465817009276 2,4-decadienoyl-CoA binding site; other site 465817009277 catalytic residue [active] 465817009278 4Fe-4S cluster binding site [ion binding]; other site 465817009279 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 465817009280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465817009281 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 465817009282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817009283 S-adenosylmethionine binding site [chemical binding]; other site 465817009284 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 465817009285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 465817009286 putative substrate translocation pore; other site 465817009287 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 465817009288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817009289 motif II; other site 465817009290 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 465817009291 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 465817009292 NAD(P) binding site [chemical binding]; other site 465817009293 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 465817009294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817009295 inhibitor-cofactor binding pocket; inhibition site 465817009296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009297 catalytic residue [active] 465817009298 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 465817009299 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 465817009300 Cl- selectivity filter; other site 465817009301 Cl- binding residues [ion binding]; other site 465817009302 pore gating glutamate residue; other site 465817009303 dimer interface [polypeptide binding]; other site 465817009304 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 465817009305 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 465817009306 serine/threonine transporter SstT; Provisional; Region: PRK13628 465817009307 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465817009308 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 465817009309 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 465817009310 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 465817009311 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 465817009312 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 465817009313 Predicted membrane protein [Function unknown]; Region: COG5393 465817009314 YqjK-like protein; Region: YqjK; pfam13997 465817009315 Predicted membrane protein [Function unknown]; Region: COG2259 465817009316 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 465817009317 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 465817009318 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 465817009319 putative dimer interface [polypeptide binding]; other site 465817009320 N-terminal domain interface [polypeptide binding]; other site 465817009321 putative substrate binding pocket (H-site) [chemical binding]; other site 465817009322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817009323 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 465817009324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817009325 dimerization interface [polypeptide binding]; other site 465817009326 Pirin-related protein [General function prediction only]; Region: COG1741 465817009327 Pirin; Region: Pirin; pfam02678 465817009328 Condensation domain; Region: Condensation; pfam00668 465817009329 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 465817009330 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 465817009331 acyl-activating enzyme (AAE) consensus motif; other site 465817009332 AMP binding site [chemical binding]; other site 465817009333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 465817009334 Condensation domain; Region: Condensation; pfam00668 465817009335 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 465817009336 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 465817009337 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 465817009338 acyl-activating enzyme (AAE) consensus motif; other site 465817009339 AMP binding site [chemical binding]; other site 465817009340 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 465817009341 Condensation domain; Region: Condensation; pfam00668 465817009342 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 465817009343 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 465817009344 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 465817009345 acyl-activating enzyme (AAE) consensus motif; other site 465817009346 AMP binding site [chemical binding]; other site 465817009347 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 465817009348 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 465817009349 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 465817009350 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 465817009351 putative SAM binding site [chemical binding]; other site 465817009352 putative homodimer interface [polypeptide binding]; other site 465817009353 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 465817009354 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 465817009355 putative ligand binding site [chemical binding]; other site 465817009356 hypothetical protein; Reviewed; Region: PRK12497 465817009357 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 465817009358 dimer interface [polypeptide binding]; other site 465817009359 active site 465817009360 outer membrane lipoprotein; Provisional; Region: PRK11023 465817009361 BON domain; Region: BON; pfam04972 465817009362 BON domain; Region: BON; pfam04972 465817009363 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 465817009364 HTH domain; Region: HTH_11; pfam08279 465817009365 Mga helix-turn-helix domain; Region: Mga; pfam05043 465817009366 PRD domain; Region: PRD; pfam00874 465817009367 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 465817009368 active site 465817009369 P-loop; other site 465817009370 phosphorylation site [posttranslational modification] 465817009371 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 465817009372 active site 465817009373 phosphorylation site [posttranslational modification] 465817009374 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 465817009375 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 465817009376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 465817009377 catalytic residue [active] 465817009378 dihydroorotase; Provisional; Region: PRK09237 465817009379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 465817009380 active site 465817009381 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 465817009382 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 465817009383 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 465817009384 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 465817009385 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 465817009386 peptidase PmbA; Provisional; Region: PRK11040 465817009387 hypothetical protein; Provisional; Region: PRK05255 465817009388 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 465817009389 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 465817009390 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 465817009391 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 465817009392 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 465817009393 AMP binding site [chemical binding]; other site 465817009394 metal binding site [ion binding]; metal-binding site 465817009395 active site 465817009396 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 465817009397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817009398 dimerization interface [polypeptide binding]; other site 465817009399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817009400 dimer interface [polypeptide binding]; other site 465817009401 putative CheW interface [polypeptide binding]; other site 465817009402 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 465817009403 dimer interface [polypeptide binding]; other site 465817009404 substrate binding site [chemical binding]; other site 465817009405 metal binding sites [ion binding]; metal-binding site 465817009406 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 465817009407 putative active site pocket [active] 465817009408 dimerization interface [polypeptide binding]; other site 465817009409 putative catalytic residue [active] 465817009410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 465817009411 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 465817009412 Family of unknown function (DUF490); Region: DUF490; pfam04357 465817009413 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 465817009414 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 465817009415 Surface antigen; Region: Bac_surface_Ag; pfam01103 465817009416 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 465817009417 Domain of unknown function DUF21; Region: DUF21; pfam01595 465817009418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 465817009419 Transporter associated domain; Region: CorC_HlyC; smart01091 465817009420 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 465817009421 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 465817009422 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 465817009423 active site 465817009424 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 465817009425 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 465817009426 active site 465817009427 metal binding site [ion binding]; metal-binding site 465817009428 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 465817009429 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 465817009430 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 465817009431 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817009432 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 465817009433 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 465817009434 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 465817009435 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 465817009436 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 465817009437 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 465817009438 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 465817009439 dimer interface [polypeptide binding]; other site 465817009440 ssDNA binding site [nucleotide binding]; other site 465817009441 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465817009442 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 465817009443 esterase; Provisional; Region: PRK10566 465817009444 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 465817009445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817009446 dimerization interface [polypeptide binding]; other site 465817009447 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 465817009448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817009449 dimer interface [polypeptide binding]; other site 465817009450 putative CheW interface [polypeptide binding]; other site 465817009451 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 465817009452 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 465817009453 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 465817009454 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 465817009455 exoribonuclease R; Provisional; Region: PRK11642 465817009456 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 465817009457 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 465817009458 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465817009459 RNB domain; Region: RNB; pfam00773 465817009460 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 465817009461 RNA binding site [nucleotide binding]; other site 465817009462 Predicted transcriptional regulator [Transcription]; Region: COG1959 465817009463 transcriptional repressor NsrR; Provisional; Region: PRK11014 465817009464 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 465817009465 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 465817009466 GDP-binding site [chemical binding]; other site 465817009467 ACT binding site; other site 465817009468 IMP binding site; other site 465817009469 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 465817009470 FtsH protease regulator HflC; Provisional; Region: PRK11029 465817009471 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 465817009472 FtsH protease regulator HflK; Provisional; Region: PRK10930 465817009473 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 465817009474 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 465817009475 GTPase HflX; Provisional; Region: PRK11058 465817009476 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 465817009477 HflX GTPase family; Region: HflX; cd01878 465817009478 G1 box; other site 465817009479 GTP/Mg2+ binding site [chemical binding]; other site 465817009480 Switch I region; other site 465817009481 G2 box; other site 465817009482 G3 box; other site 465817009483 Switch II region; other site 465817009484 G4 box; other site 465817009485 G5 box; other site 465817009486 bacterial Hfq-like; Region: Hfq; cd01716 465817009487 hexamer interface [polypeptide binding]; other site 465817009488 Sm1 motif; other site 465817009489 RNA binding site [nucleotide binding]; other site 465817009490 Sm2 motif; other site 465817009491 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 465817009492 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 465817009493 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 465817009494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817009495 ATP binding site [chemical binding]; other site 465817009496 Mg2+ binding site [ion binding]; other site 465817009497 G-X-G motif; other site 465817009498 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 465817009499 ATP binding site [chemical binding]; other site 465817009500 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 465817009501 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 465817009502 AMIN domain; Region: AMIN; pfam11741 465817009503 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 465817009504 active site 465817009505 metal binding site [ion binding]; metal-binding site 465817009506 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817009507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 465817009508 ADP-binding protein; Provisional; Region: PRK10646 465817009509 putative carbohydrate kinase; Provisional; Region: PRK10565 465817009510 Uncharacterized conserved protein [Function unknown]; Region: COG0062 465817009511 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 465817009512 putative substrate binding site [chemical binding]; other site 465817009513 putative ATP binding site [chemical binding]; other site 465817009514 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 465817009515 catalytic site [active] 465817009516 putative active site [active] 465817009517 putative substrate binding site [chemical binding]; other site 465817009518 dimer interface [polypeptide binding]; other site 465817009519 GTPase RsgA; Reviewed; Region: PRK12288 465817009520 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 465817009521 RNA binding site [nucleotide binding]; other site 465817009522 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 465817009523 GTPase/Zn-binding domain interface [polypeptide binding]; other site 465817009524 GTP/Mg2+ binding site [chemical binding]; other site 465817009525 G4 box; other site 465817009526 G5 box; other site 465817009527 G1 box; other site 465817009528 Switch I region; other site 465817009529 G2 box; other site 465817009530 G3 box; other site 465817009531 Switch II region; other site 465817009532 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 465817009533 putative mechanosensitive channel protein; Provisional; Region: PRK10929 465817009534 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 465817009535 Mechanosensitive ion channel; Region: MS_channel; pfam00924 465817009536 poxB regulator PoxA; Provisional; Region: PRK09350 465817009537 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 465817009538 motif 1; other site 465817009539 dimer interface [polypeptide binding]; other site 465817009540 active site 465817009541 motif 2; other site 465817009542 motif 3; other site 465817009543 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 465817009544 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 465817009545 Entericidin EcnA/B family; Region: Entericidin; cl02322 465817009546 elongation factor P; Validated; Region: PRK00529 465817009547 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 465817009548 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 465817009549 RNA binding site [nucleotide binding]; other site 465817009550 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 465817009551 RNA binding site [nucleotide binding]; other site 465817009552 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 465817009553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 465817009554 FeS/SAM binding site; other site 465817009555 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 465817009556 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 465817009557 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 465817009558 ring oligomerisation interface [polypeptide binding]; other site 465817009559 ATP/Mg binding site [chemical binding]; other site 465817009560 stacking interactions; other site 465817009561 hinge regions; other site 465817009562 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 465817009563 oligomerisation interface [polypeptide binding]; other site 465817009564 mobile loop; other site 465817009565 roof hairpin; other site 465817009566 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 465817009567 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 465817009568 Aspartase; Region: Aspartase; cd01357 465817009569 active sites [active] 465817009570 tetramer interface [polypeptide binding]; other site 465817009571 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 465817009572 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 465817009573 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 465817009574 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 465817009575 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 465817009576 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 465817009577 DsbD alpha interface [polypeptide binding]; other site 465817009578 catalytic residues [active] 465817009579 putative transcriptional regulator; Provisional; Region: PRK11640 465817009580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 465817009581 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 465817009582 RHS protein; Region: RHS; pfam03527 465817009583 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 465817009584 RHS protein; Region: RHS; pfam03527 465817009585 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817009586 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817009587 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 465817009588 PAAR motif; Region: PAAR_motif; pfam05488 465817009589 RHS Repeat; Region: RHS_repeat; pfam05593 465817009590 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817009591 RHS Repeat; Region: RHS_repeat; pfam05593 465817009592 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 465817009593 RHS Repeat; Region: RHS_repeat; cl11982 465817009594 RHS Repeat; Region: RHS_repeat; pfam05593 465817009595 RHS protein; Region: RHS; pfam03527 465817009596 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817009597 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 465817009598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817009599 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817009600 DNA binding site [nucleotide binding] 465817009601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 465817009602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 465817009603 NAD(P) binding site [chemical binding]; other site 465817009604 active site 465817009605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 465817009606 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 465817009607 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 465817009608 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 465817009609 dimer interface [polypeptide binding]; other site 465817009610 active site 465817009611 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 465817009612 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 465817009613 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 465817009614 Walker A/P-loop; other site 465817009615 ATP binding site [chemical binding]; other site 465817009616 Q-loop/lid; other site 465817009617 ABC transporter signature motif; other site 465817009618 Walker B; other site 465817009619 D-loop; other site 465817009620 H-loop/switch region; other site 465817009621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 465817009622 FtsX-like permease family; Region: FtsX; pfam02687 465817009623 macrolide transporter subunit MacA; Provisional; Region: PRK11578 465817009624 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 465817009625 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817009626 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 465817009627 putative active site [active] 465817009628 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465817009629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817009630 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 465817009631 Walker A/P-loop; other site 465817009632 ATP binding site [chemical binding]; other site 465817009633 Q-loop/lid; other site 465817009634 ABC transporter signature motif; other site 465817009635 Walker B; other site 465817009636 D-loop; other site 465817009637 H-loop/switch region; other site 465817009638 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 465817009639 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 465817009640 catalytic residues [active] 465817009641 hinge region; other site 465817009642 alpha helical domain; other site 465817009643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 465817009644 dimerization interface [polypeptide binding]; other site 465817009645 DNA binding residues [nucleotide binding] 465817009646 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009647 Fimbrial protein; Region: Fimbrial; cl01416 465817009648 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817009649 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817009650 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817009651 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 465817009652 PapC N-terminal domain; Region: PapC_N; pfam13954 465817009653 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817009654 PapC C-terminal domain; Region: PapC_C; pfam13953 465817009655 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817009656 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 465817009657 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 465817009658 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 465817009659 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 465817009660 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 465817009661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009662 catalytic residue [active] 465817009663 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 465817009664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465817009665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 465817009666 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 465817009667 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 465817009668 IucA / IucC family; Region: IucA_IucC; pfam04183 465817009669 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 465817009670 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 465817009671 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817009672 N-terminal plug; other site 465817009673 ligand-binding site [chemical binding]; other site 465817009674 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 465817009675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817009676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817009677 DNA binding residues [nucleotide binding] 465817009678 fec operon regulator FecR; Reviewed; Region: PRK09774 465817009679 FecR protein; Region: FecR; pfam04773 465817009680 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 465817009681 Secretin and TonB N terminus short domain; Region: STN; smart00965 465817009682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 465817009683 N-terminal plug; other site 465817009684 ligand-binding site [chemical binding]; other site 465817009685 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 465817009686 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 465817009687 siderophore binding site; other site 465817009688 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817009689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817009690 ABC-ATPase subunit interface; other site 465817009691 dimer interface [polypeptide binding]; other site 465817009692 putative PBP binding regions; other site 465817009693 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 465817009694 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 465817009695 ABC-ATPase subunit interface; other site 465817009696 dimer interface [polypeptide binding]; other site 465817009697 putative PBP binding regions; other site 465817009698 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 465817009699 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 465817009700 Walker A/P-loop; other site 465817009701 ATP binding site [chemical binding]; other site 465817009702 Q-loop/lid; other site 465817009703 ABC transporter signature motif; other site 465817009704 Walker B; other site 465817009705 D-loop; other site 465817009706 H-loop/switch region; other site 465817009707 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 465817009708 glucose-1-dehydrogenase; Provisional; Region: PRK08936 465817009709 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 465817009710 NAD binding site [chemical binding]; other site 465817009711 homodimer interface [polypeptide binding]; other site 465817009712 active site 465817009713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 465817009714 dimerization interface [polypeptide binding]; other site 465817009715 putative DNA binding site [nucleotide binding]; other site 465817009716 putative Zn2+ binding site [ion binding]; other site 465817009717 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 465817009718 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 465817009719 FMN binding site [chemical binding]; other site 465817009720 active site 465817009721 substrate binding site [chemical binding]; other site 465817009722 catalytic residue [active] 465817009723 chaperone protein HchA; Provisional; Region: PRK04155 465817009724 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 465817009725 conserved cys residue [active] 465817009726 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 465817009727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817009728 active site 465817009729 motif I; other site 465817009730 motif II; other site 465817009731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 465817009732 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 465817009733 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 465817009734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 465817009735 trehalase; Provisional; Region: treF; PRK13270 465817009736 Trehalase; Region: Trehalase; cl17346 465817009737 LysE type translocator; Region: LysE; cl00565 465817009738 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 465817009739 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 465817009740 substrate binding site [chemical binding]; other site 465817009741 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 465817009742 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 465817009743 substrate binding site [chemical binding]; other site 465817009744 ligand binding site [chemical binding]; other site 465817009745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817009746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817009747 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 465817009748 putative effector binding pocket; other site 465817009749 dimerization interface [polypeptide binding]; other site 465817009750 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 465817009751 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 465817009752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 465817009753 NAD(P) binding site [chemical binding]; other site 465817009754 active site 465817009755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817009756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817009757 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 465817009758 putative effector binding pocket; other site 465817009759 putative dimerization interface [polypeptide binding]; other site 465817009760 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 465817009761 Protein of unknown function (DUF3289); Region: DUF3289; pfam11692 465817009762 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 465817009763 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 465817009764 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 465817009765 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 465817009766 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 465817009767 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 465817009768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817009769 PAS domain; Region: PAS_9; pfam13426 465817009770 putative active site [active] 465817009771 heme pocket [chemical binding]; other site 465817009772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817009773 PAS domain; Region: PAS_9; pfam13426 465817009774 putative active site [active] 465817009775 heme pocket [chemical binding]; other site 465817009776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817009777 PAS domain; Region: PAS_9; pfam13426 465817009778 putative active site [active] 465817009779 heme pocket [chemical binding]; other site 465817009780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 465817009781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817009782 metal binding site [ion binding]; metal-binding site 465817009783 active site 465817009784 I-site; other site 465817009785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817009786 microcin B17 transporter; Reviewed; Region: PRK11098 465817009787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 465817009788 PAS domain; Region: PAS_9; pfam13426 465817009789 putative active site [active] 465817009790 heme pocket [chemical binding]; other site 465817009791 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 465817009792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817009793 dimer interface [polypeptide binding]; other site 465817009794 putative CheW interface [polypeptide binding]; other site 465817009795 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 465817009796 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465817009797 acetyl-CoA synthetase; Provisional; Region: PRK00174 465817009798 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 465817009799 active site 465817009800 CoA binding site [chemical binding]; other site 465817009801 acyl-activating enzyme (AAE) consensus motif; other site 465817009802 AMP binding site [chemical binding]; other site 465817009803 acetate binding site [chemical binding]; other site 465817009804 Predicted membrane protein [Function unknown]; Region: COG3162 465817009805 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 465817009806 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 465817009807 Na binding site [ion binding]; other site 465817009808 YfaZ precursor; Region: YfaZ; pfam07437 465817009809 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 465817009810 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 465817009811 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 465817009812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817009813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817009814 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 465817009815 putative dimerization interface [polypeptide binding]; other site 465817009816 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 465817009817 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 465817009818 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 465817009819 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 465817009820 putative C-terminal domain interface [polypeptide binding]; other site 465817009821 putative GSH binding site (G-site) [chemical binding]; other site 465817009822 putative dimer interface [polypeptide binding]; other site 465817009823 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 465817009824 putative N-terminal domain interface [polypeptide binding]; other site 465817009825 putative dimer interface [polypeptide binding]; other site 465817009826 putative substrate binding pocket (H-site) [chemical binding]; other site 465817009827 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 465817009828 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 465817009829 DNA binding residues [nucleotide binding] 465817009830 dimer interface [polypeptide binding]; other site 465817009831 [2Fe-2S] cluster binding site [ion binding]; other site 465817009832 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 465817009833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817009834 silverDB:etchr03067 465817009835 Protein of unknown function (DUF535); Region: DUF535; pfam04393 465817009836 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 465817009837 haemagglutination activity domain; Region: Haemagg_act; pfam05860 465817009838 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 465817009839 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 465817009840 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 465817009841 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 465817009842 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 465817009843 dimer interface [polypeptide binding]; other site 465817009844 ssDNA binding site [nucleotide binding]; other site 465817009845 tetramer (dimer of dimers) interface [polypeptide binding]; other site 465817009846 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 465817009847 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 465817009848 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 465817009849 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 465817009850 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 465817009851 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 465817009852 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 465817009853 putative NAD(P) binding site [chemical binding]; other site 465817009854 putative substrate binding site [chemical binding]; other site 465817009855 catalytic Zn binding site [ion binding]; other site 465817009856 structural Zn binding site [ion binding]; other site 465817009857 dimer interface [polypeptide binding]; other site 465817009858 LysM domain; Region: LysM; pfam01476 465817009859 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 465817009860 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 465817009861 Filamin/ABP280 repeat; Region: Filamin; pfam00630 465817009862 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 465817009863 Uncharacterized conserved protein [Function unknown]; Region: COG0432 465817009864 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 465817009865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817009866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817009867 homodimer interface [polypeptide binding]; other site 465817009868 catalytic residue [active] 465817009869 Uncharacterized conserved protein [Function unknown]; Region: COG1284 465817009870 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 465817009871 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 465817009872 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 465817009873 putative DNA binding site [nucleotide binding]; other site 465817009874 putative Zn2+ binding site [ion binding]; other site 465817009875 AsnC family; Region: AsnC_trans_reg; pfam01037 465817009876 replicative DNA helicase; Provisional; Region: PRK08006 465817009877 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 465817009878 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 465817009879 Walker A motif; other site 465817009880 ATP binding site [chemical binding]; other site 465817009881 Walker B motif; other site 465817009882 DNA binding loops [nucleotide binding] 465817009883 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 465817009884 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 465817009885 NADP binding site [chemical binding]; other site 465817009886 dimer interface [polypeptide binding]; other site 465817009887 phage shock protein G; Reviewed; Region: pspG; PRK09459 465817009888 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 465817009889 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 465817009890 FMN binding site [chemical binding]; other site 465817009891 active site 465817009892 catalytic residues [active] 465817009893 substrate binding site [chemical binding]; other site 465817009894 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 465817009895 ferric uptake regulator; Provisional; Region: fur; PRK09462 465817009896 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 465817009897 metal binding site 2 [ion binding]; metal-binding site 465817009898 putative DNA binding helix; other site 465817009899 metal binding site 1 [ion binding]; metal-binding site 465817009900 dimer interface [polypeptide binding]; other site 465817009901 structural Zn2+ binding site [ion binding]; other site 465817009902 hypothetical protein; Provisional; Region: PRK10428 465817009903 LexA repressor; Validated; Region: PRK00215 465817009904 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 465817009905 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 465817009906 Catalytic site [active] 465817009907 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 465817009908 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 465817009909 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 465817009910 putative acyl-acceptor binding pocket; other site 465817009911 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 465817009912 UbiA prenyltransferase family; Region: UbiA; pfam01040 465817009913 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 465817009914 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 465817009915 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 465817009916 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 465817009917 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 465817009918 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 465817009919 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 465817009920 active site 465817009921 dimer interface [polypeptide binding]; other site 465817009922 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 465817009923 dimer interface [polypeptide binding]; other site 465817009924 active site 465817009925 aspartate kinase III; Validated; Region: PRK09084 465817009926 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 465817009927 nucleotide binding site [chemical binding]; other site 465817009928 substrate binding site [chemical binding]; other site 465817009929 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 465817009930 lysine allosteric regulatory site; other site 465817009931 dimer interface [polypeptide binding]; other site 465817009932 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 465817009933 dimer interface [polypeptide binding]; other site 465817009934 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 465817009935 Sodium Bile acid symporter family; Region: SBF; pfam01758 465817009936 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 465817009937 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 465817009938 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 465817009939 PhoU domain; Region: PhoU; pfam01895 465817009940 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 465817009941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817009942 Walker A/P-loop; other site 465817009943 ATP binding site [chemical binding]; other site 465817009944 Q-loop/lid; other site 465817009945 ABC transporter signature motif; other site 465817009946 Walker B; other site 465817009947 D-loop; other site 465817009948 H-loop/switch region; other site 465817009949 TOBE domain; Region: TOBE_2; pfam08402 465817009950 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 465817009951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817009952 dimer interface [polypeptide binding]; other site 465817009953 conserved gate region; other site 465817009954 putative PBP binding loops; other site 465817009955 ABC-ATPase subunit interface; other site 465817009956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817009957 dimer interface [polypeptide binding]; other site 465817009958 conserved gate region; other site 465817009959 ABC-ATPase subunit interface; other site 465817009960 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 465817009961 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 465817009962 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 465817009963 homoserine O-succinyltransferase; Provisional; Region: PRK05368 465817009964 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 465817009965 proposed active site lysine [active] 465817009966 conserved cys residue [active] 465817009967 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 465817009968 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 465817009969 trimer interface [polypeptide binding]; other site 465817009970 putative metal binding site [ion binding]; other site 465817009971 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 465817009972 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 465817009973 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 465817009974 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 465817009975 shikimate binding site; other site 465817009976 NAD(P) binding site [chemical binding]; other site 465817009977 silverDB:etchr03111 465817009978 silverDB:etchr03112 465817009979 hypothetical protein; Validated; Region: PRK03430 465817009980 hypothetical protein; Provisional; Region: PRK10736 465817009981 DNA protecting protein DprA; Region: dprA; TIGR00732 465817009982 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 465817009983 active site 465817009984 catalytic residues [active] 465817009985 metal binding site [ion binding]; metal-binding site 465817009986 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 465817009987 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 465817009988 putative active site [active] 465817009989 substrate binding site [chemical binding]; other site 465817009990 putative cosubstrate binding site; other site 465817009991 catalytic site [active] 465817009992 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 465817009993 substrate binding site [chemical binding]; other site 465817009994 16S rRNA methyltransferase B; Provisional; Region: PRK10901 465817009995 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 465817009996 putative RNA binding site [nucleotide binding]; other site 465817009997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817009998 S-adenosylmethionine binding site [chemical binding]; other site 465817009999 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 465817010000 TrkA-N domain; Region: TrkA_N; pfam02254 465817010001 TrkA-C domain; Region: TrkA_C; pfam02080 465817010002 TrkA-N domain; Region: TrkA_N; pfam02254 465817010003 TrkA-C domain; Region: TrkA_C; pfam02080 465817010004 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 465817010005 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 465817010006 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 465817010007 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 465817010008 DNA binding residues [nucleotide binding] 465817010009 dimer interface [polypeptide binding]; other site 465817010010 metal binding site [ion binding]; metal-binding site 465817010011 hypothetical protein; Provisional; Region: PRK10203 465817010012 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 465817010013 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 465817010014 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 465817010015 alphaNTD homodimer interface [polypeptide binding]; other site 465817010016 alphaNTD - beta interaction site [polypeptide binding]; other site 465817010017 alphaNTD - beta' interaction site [polypeptide binding]; other site 465817010018 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 465817010019 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 465817010020 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 465817010021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817010022 RNA binding surface [nucleotide binding]; other site 465817010023 30S ribosomal protein S11; Validated; Region: PRK05309 465817010024 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 465817010025 30S ribosomal protein S13; Region: bact_S13; TIGR03631 465817010026 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 465817010027 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 465817010028 SecY translocase; Region: SecY; pfam00344 465817010029 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 465817010030 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 465817010031 23S rRNA binding site [nucleotide binding]; other site 465817010032 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 465817010033 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 465817010034 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 465817010035 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 465817010036 23S rRNA interface [nucleotide binding]; other site 465817010037 5S rRNA interface [nucleotide binding]; other site 465817010038 L27 interface [polypeptide binding]; other site 465817010039 L5 interface [polypeptide binding]; other site 465817010040 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 465817010041 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 465817010042 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 465817010043 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 465817010044 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 465817010045 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 465817010046 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 465817010047 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 465817010048 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 465817010049 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 465817010050 RNA binding site [nucleotide binding]; other site 465817010051 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 465817010052 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 465817010053 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 465817010054 23S rRNA interface [nucleotide binding]; other site 465817010055 putative translocon interaction site; other site 465817010056 signal recognition particle (SRP54) interaction site; other site 465817010057 L23 interface [polypeptide binding]; other site 465817010058 trigger factor interaction site; other site 465817010059 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 465817010060 23S rRNA interface [nucleotide binding]; other site 465817010061 5S rRNA interface [nucleotide binding]; other site 465817010062 putative antibiotic binding site [chemical binding]; other site 465817010063 L25 interface [polypeptide binding]; other site 465817010064 L27 interface [polypeptide binding]; other site 465817010065 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 465817010066 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 465817010067 G-X-X-G motif; other site 465817010068 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 465817010069 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 465817010070 protein-rRNA interface [nucleotide binding]; other site 465817010071 putative translocon binding site; other site 465817010072 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 465817010073 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 465817010074 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 465817010075 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 465817010076 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 465817010077 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 465817010078 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 465817010079 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 465817010080 elongation factor Tu; Reviewed; Region: PRK00049 465817010081 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 465817010082 G1 box; other site 465817010083 GEF interaction site [polypeptide binding]; other site 465817010084 GTP/Mg2+ binding site [chemical binding]; other site 465817010085 Switch I region; other site 465817010086 G2 box; other site 465817010087 G3 box; other site 465817010088 Switch II region; other site 465817010089 G4 box; other site 465817010090 G5 box; other site 465817010091 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 465817010092 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 465817010093 Antibiotic Binding Site [chemical binding]; other site 465817010094 elongation factor G; Reviewed; Region: PRK00007 465817010095 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 465817010096 G1 box; other site 465817010097 putative GEF interaction site [polypeptide binding]; other site 465817010098 GTP/Mg2+ binding site [chemical binding]; other site 465817010099 Switch I region; other site 465817010100 G2 box; other site 465817010101 G3 box; other site 465817010102 Switch II region; other site 465817010103 G4 box; other site 465817010104 G5 box; other site 465817010105 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 465817010106 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 465817010107 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 465817010108 30S ribosomal protein S7; Validated; Region: PRK05302 465817010109 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 465817010110 S17 interaction site [polypeptide binding]; other site 465817010111 S8 interaction site; other site 465817010112 16S rRNA interaction site [nucleotide binding]; other site 465817010113 streptomycin interaction site [chemical binding]; other site 465817010114 23S rRNA interaction site [nucleotide binding]; other site 465817010115 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 465817010116 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 465817010117 sulfur relay protein TusC; Validated; Region: PRK00211 465817010118 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 465817010119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 465817010120 YheO-like PAS domain; Region: PAS_6; pfam08348 465817010121 HTH domain; Region: HTH_22; pfam13309 465817010122 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 465817010123 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 465817010124 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817010125 phi X174 lysis protein; Provisional; Region: PRK02793 465817010126 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 465817010127 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 465817010128 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 465817010129 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 465817010130 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 465817010131 TrkA-N domain; Region: TrkA_N; pfam02254 465817010132 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 465817010133 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 465817010134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010135 Walker A/P-loop; other site 465817010136 ATP binding site [chemical binding]; other site 465817010137 Q-loop/lid; other site 465817010138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817010139 ABC transporter; Region: ABC_tran_2; pfam12848 465817010140 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 465817010141 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 465817010142 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 465817010143 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 465817010144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010145 dimer interface [polypeptide binding]; other site 465817010146 conserved gate region; other site 465817010147 putative PBP binding loops; other site 465817010148 ABC-ATPase subunit interface; other site 465817010149 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 465817010150 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 465817010151 Walker A/P-loop; other site 465817010152 ATP binding site [chemical binding]; other site 465817010153 Q-loop/lid; other site 465817010154 ABC transporter signature motif; other site 465817010155 Walker B; other site 465817010156 D-loop; other site 465817010157 H-loop/switch region; other site 465817010158 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 465817010159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817010160 substrate binding pocket [chemical binding]; other site 465817010161 membrane-bound complex binding site; other site 465817010162 hinge residues; other site 465817010163 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 465817010164 putative hydrolase; Provisional; Region: PRK10985 465817010165 hypothetical protein; Provisional; Region: PRK04966 465817010166 phosphoribulokinase; Provisional; Region: PRK15453 465817010167 active site 465817010168 hypothetical protein; Provisional; Region: PRK10738 465817010169 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 465817010170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 465817010171 ligand binding site [chemical binding]; other site 465817010172 flexible hinge region; other site 465817010173 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 465817010174 putative switch regulator; other site 465817010175 non-specific DNA interactions [nucleotide binding]; other site 465817010176 DNA binding site [nucleotide binding] 465817010177 sequence specific DNA binding site [nucleotide binding]; other site 465817010178 putative cAMP binding site [chemical binding]; other site 465817010179 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 465817010180 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 465817010181 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 465817010182 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 465817010183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817010184 inhibitor-cofactor binding pocket; inhibition site 465817010185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817010186 catalytic residue [active] 465817010187 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 465817010188 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 465817010189 glutamine binding [chemical binding]; other site 465817010190 catalytic triad [active] 465817010191 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 465817010192 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 465817010193 substrate binding site [chemical binding]; other site 465817010194 putative transporter; Provisional; Region: PRK03699 465817010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817010196 putative substrate translocation pore; other site 465817010197 silverDB:etchr03182 465817010198 silverDB:etchr03183 465817010199 cytosine deaminase; Provisional; Region: PRK09230 465817010200 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 465817010201 active site 465817010202 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 465817010203 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 465817010204 active site 465817010205 HIGH motif; other site 465817010206 dimer interface [polypeptide binding]; other site 465817010207 KMSKS motif; other site 465817010208 phosphoglycolate phosphatase; Provisional; Region: PRK13222 465817010209 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 465817010210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817010211 motif II; other site 465817010212 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 465817010213 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 465817010214 substrate binding site [chemical binding]; other site 465817010215 hexamer interface [polypeptide binding]; other site 465817010216 metal binding site [ion binding]; metal-binding site 465817010217 DNA adenine methylase; Provisional; Region: PRK10904 465817010218 hypothetical protein; Reviewed; Region: PRK11901 465817010219 cell division protein DamX; Validated; Region: PRK10905 465817010220 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 465817010221 active site 465817010222 dimer interface [polypeptide binding]; other site 465817010223 metal binding site [ion binding]; metal-binding site 465817010224 shikimate kinase; Reviewed; Region: aroK; PRK00131 465817010225 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 465817010226 ADP binding site [chemical binding]; other site 465817010227 magnesium binding site [ion binding]; other site 465817010228 putative shikimate binding site; other site 465817010229 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 465817010230 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 465817010231 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 465817010232 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 465817010233 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 465817010234 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 465817010235 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 465817010236 Transglycosylase; Region: Transgly; pfam00912 465817010237 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 465817010238 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 465817010239 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 465817010240 ADP-ribose binding site [chemical binding]; other site 465817010241 dimer interface [polypeptide binding]; other site 465817010242 active site 465817010243 nudix motif; other site 465817010244 metal binding site [ion binding]; metal-binding site 465817010245 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 465817010246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 465817010247 RNA binding surface [nucleotide binding]; other site 465817010248 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 465817010249 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 465817010250 dimerization interface [polypeptide binding]; other site 465817010251 domain crossover interface; other site 465817010252 redox-dependent activation switch; other site 465817010253 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 465817010254 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 465817010255 active site 465817010256 substrate-binding site [chemical binding]; other site 465817010257 metal-binding site [ion binding] 465817010258 ATP binding site [chemical binding]; other site 465817010259 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 465817010260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 465817010261 dimerization interface [polypeptide binding]; other site 465817010262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817010263 dimer interface [polypeptide binding]; other site 465817010264 phosphorylation site [posttranslational modification] 465817010265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817010266 ATP binding site [chemical binding]; other site 465817010267 G-X-G motif; other site 465817010268 osmolarity response regulator; Provisional; Region: ompR; PRK09468 465817010269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 465817010270 active site 465817010271 phosphorylation site [posttranslational modification] 465817010272 intermolecular recognition site; other site 465817010273 dimerization interface [polypeptide binding]; other site 465817010274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 465817010275 DNA binding site [nucleotide binding] 465817010276 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 465817010277 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 465817010278 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 465817010279 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 465817010280 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 465817010281 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 465817010282 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 465817010283 RNA binding site [nucleotide binding]; other site 465817010284 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 465817010285 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 465817010286 sucrose phosphorylase; Provisional; Region: PRK13840 465817010287 active site 465817010288 homodimer interface [polypeptide binding]; other site 465817010289 catalytic site [active] 465817010290 carboxylesterase BioH; Provisional; Region: PRK10349 465817010291 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 465817010292 DNA utilization protein GntX; Provisional; Region: PRK11595 465817010293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 465817010294 active site 465817010295 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 465817010296 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 465817010297 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 465817010298 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 465817010299 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 465817010300 silverDB:etchr03217 465817010301 silverDB:etchr03218 465817010302 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 465817010303 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 465817010304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 465817010305 intramembrane serine protease GlpG; Provisional; Region: PRK10907 465817010306 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 465817010307 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 465817010308 SIR2-like domain; Region: SIR2_2; pfam13289 465817010309 Replicase family; Region: Replicase; pfam03090 465817010310 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 465817010311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817010312 non-specific DNA binding site [nucleotide binding]; other site 465817010313 salt bridge; other site 465817010314 sequence-specific DNA binding site [nucleotide binding]; other site 465817010315 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 465817010316 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 465817010317 active site residue [active] 465817010318 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 465817010319 glycogen phosphorylase; Provisional; Region: PRK14986 465817010320 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 465817010321 homodimer interface [polypeptide binding]; other site 465817010322 active site pocket [active] 465817010323 glycogen synthase; Provisional; Region: glgA; PRK00654 465817010324 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 465817010325 ADP-binding pocket [chemical binding]; other site 465817010326 homodimer interface [polypeptide binding]; other site 465817010327 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 465817010328 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 465817010329 ligand binding site; other site 465817010330 oligomer interface; other site 465817010331 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 465817010332 dimer interface [polypeptide binding]; other site 465817010333 N-terminal domain interface [polypeptide binding]; other site 465817010334 sulfate 1 binding site; other site 465817010335 glycogen debranching enzyme; Provisional; Region: PRK03705 465817010336 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 465817010337 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 465817010338 active site 465817010339 catalytic site [active] 465817010340 glycogen branching enzyme; Provisional; Region: PRK05402 465817010341 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 465817010342 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 465817010343 active site 465817010344 catalytic site [active] 465817010345 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 465817010346 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 465817010347 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 465817010348 low affinity gluconate transporter; Provisional; Region: PRK10472 465817010349 gluconate transporter; Region: gntP; TIGR00791 465817010350 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 465817010351 ATP-binding site [chemical binding]; other site 465817010352 Gluconate-6-phosphate binding site [chemical binding]; other site 465817010353 Shikimate kinase; Region: SKI; pfam01202 465817010354 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 465817010355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817010356 DNA binding site [nucleotide binding] 465817010357 domain linker motif; other site 465817010358 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 465817010359 putative ligand binding site [chemical binding]; other site 465817010360 putative dimerization interface [polypeptide binding]; other site 465817010361 Pirin-related protein [General function prediction only]; Region: COG1741 465817010362 Pirin; Region: Pirin; pfam02678 465817010363 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 465817010364 putative acetyltransferase YhhY; Provisional; Region: PRK10140 465817010365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 465817010366 Coenzyme A binding pocket [chemical binding]; other site 465817010367 silverDB:etchr03243 465817010368 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 465817010369 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 465817010370 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 465817010371 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 465817010372 putative active site [active] 465817010373 catalytic site [active] 465817010374 putative metal binding site [ion binding]; other site 465817010375 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 465817010376 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 465817010377 Walker A/P-loop; other site 465817010378 ATP binding site [chemical binding]; other site 465817010379 Q-loop/lid; other site 465817010380 ABC transporter signature motif; other site 465817010381 Walker B; other site 465817010382 D-loop; other site 465817010383 H-loop/switch region; other site 465817010384 TOBE domain; Region: TOBE_2; pfam08402 465817010385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 465817010386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010387 dimer interface [polypeptide binding]; other site 465817010388 conserved gate region; other site 465817010389 putative PBP binding loops; other site 465817010390 ABC-ATPase subunit interface; other site 465817010391 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 465817010392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010393 dimer interface [polypeptide binding]; other site 465817010394 conserved gate region; other site 465817010395 putative PBP binding loops; other site 465817010396 ABC-ATPase subunit interface; other site 465817010397 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 465817010398 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 465817010399 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 465817010400 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 465817010401 Walker A/P-loop; other site 465817010402 ATP binding site [chemical binding]; other site 465817010403 Q-loop/lid; other site 465817010404 ABC transporter signature motif; other site 465817010405 Walker B; other site 465817010406 D-loop; other site 465817010407 H-loop/switch region; other site 465817010408 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 465817010409 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 465817010410 Walker A/P-loop; other site 465817010411 ATP binding site [chemical binding]; other site 465817010412 Q-loop/lid; other site 465817010413 ABC transporter signature motif; other site 465817010414 Walker B; other site 465817010415 D-loop; other site 465817010416 H-loop/switch region; other site 465817010417 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 465817010418 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 465817010419 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 465817010420 TM-ABC transporter signature motif; other site 465817010421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817010422 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 465817010423 TM-ABC transporter signature motif; other site 465817010424 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 465817010425 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 465817010426 dimerization interface [polypeptide binding]; other site 465817010427 ligand binding site [chemical binding]; other site 465817010428 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 465817010429 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 465817010430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 465817010431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 465817010432 DNA binding residues [nucleotide binding] 465817010433 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 465817010434 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 465817010435 cell division protein FtsE; Provisional; Region: PRK10908 465817010436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010437 Walker A/P-loop; other site 465817010438 ATP binding site [chemical binding]; other site 465817010439 Q-loop/lid; other site 465817010440 ABC transporter signature motif; other site 465817010441 Walker B; other site 465817010442 D-loop; other site 465817010443 H-loop/switch region; other site 465817010444 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 465817010445 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 465817010446 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 465817010447 P loop; other site 465817010448 GTP binding site [chemical binding]; other site 465817010449 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 465817010450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817010451 S-adenosylmethionine binding site [chemical binding]; other site 465817010452 hypothetical protein; Provisional; Region: PRK10910 465817010453 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 465817010454 Predicted membrane protein [Function unknown]; Region: COG3714 465817010455 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 465817010456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 465817010457 metal-binding site [ion binding] 465817010458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465817010459 Soluble P-type ATPase [General function prediction only]; Region: COG4087 465817010460 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 465817010461 CPxP motif; other site 465817010462 hypothetical protein; Provisional; Region: PRK11212 465817010463 hypothetical protein; Provisional; Region: PRK11615 465817010464 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 465817010465 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 465817010466 Metal-binding active site; metal-binding site 465817010467 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 465817010468 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 465817010469 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 465817010470 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 465817010471 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 465817010472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 465817010473 PYR/PP interface [polypeptide binding]; other site 465817010474 dimer interface [polypeptide binding]; other site 465817010475 TPP binding site [chemical binding]; other site 465817010476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 465817010477 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 465817010478 TPP-binding site; other site 465817010479 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817010480 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 465817010481 substrate binding site [chemical binding]; other site 465817010482 ATP binding site [chemical binding]; other site 465817010483 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 465817010484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 465817010485 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 465817010486 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 465817010487 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 465817010488 putative active site [active] 465817010489 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 465817010490 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 465817010491 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 465817010492 tetrameric interface [polypeptide binding]; other site 465817010493 NAD binding site [chemical binding]; other site 465817010494 catalytic residues [active] 465817010495 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 465817010496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 465817010497 Domain of unknown function DUF20; Region: UPF0118; pfam01594 465817010498 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 465817010499 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817010500 proline/glycine betaine transporter; Provisional; Region: PRK10642 465817010501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817010502 putative substrate translocation pore; other site 465817010503 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 465817010504 Fimbrial protein; Region: Fimbrial; cl01416 465817010505 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 465817010506 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817010507 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817010508 outer membrane usher protein; Provisional; Region: PRK15193 465817010509 PapC N-terminal domain; Region: PapC_N; pfam13954 465817010510 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817010511 PapC C-terminal domain; Region: PapC_C; pfam13953 465817010512 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817010513 Fimbrial protein; Region: Fimbrial; pfam00419 465817010514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 465817010515 Transposase; Region: HTH_Tnp_1; pfam01527 465817010516 putative transposase OrfB; Reviewed; Region: PHA02517 465817010517 HTH-like domain; Region: HTH_21; pfam13276 465817010518 Integrase core domain; Region: rve; pfam00665 465817010519 Integrase core domain; Region: rve_3; pfam13683 465817010520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817010521 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 465817010522 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 465817010523 putative NAD(P) binding site [chemical binding]; other site 465817010524 putative substrate binding site [chemical binding]; other site 465817010525 catalytic Zn binding site [ion binding]; other site 465817010526 structural Zn binding site [ion binding]; other site 465817010527 dimer interface [polypeptide binding]; other site 465817010528 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 465817010529 DNA binding residues [nucleotide binding] 465817010530 dimerization interface [polypeptide binding]; other site 465817010531 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 465817010532 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 465817010533 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 465817010534 homotrimer interaction site [polypeptide binding]; other site 465817010535 putative active site [active] 465817010536 ornithine cyclodeaminase; Validated; Region: PRK06199 465817010537 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 465817010538 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 465817010539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817010540 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 465817010541 Predicted flavoproteins [General function prediction only]; Region: COG2081 465817010542 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 465817010543 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 465817010544 universal stress protein UspB; Provisional; Region: PRK04960 465817010545 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 465817010546 Ligand Binding Site [chemical binding]; other site 465817010547 putative methyltransferase; Provisional; Region: PRK10742 465817010548 oligopeptidase A; Provisional; Region: PRK10911 465817010549 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 465817010550 active site 465817010551 Zn binding site [ion binding]; other site 465817010552 CAAX protease self-immunity; Region: Abi; pfam02517 465817010553 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 465817010554 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 465817010555 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 465817010556 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 465817010557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 465817010558 ATP binding site [chemical binding]; other site 465817010559 putative Mg++ binding site [ion binding]; other site 465817010560 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 465817010561 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 465817010562 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 465817010563 HsdM N-terminal domain; Region: HsdM_N; pfam12161 465817010564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 465817010565 S-adenosylmethionine binding site [chemical binding]; other site 465817010566 glutathione reductase; Validated; Region: PRK06116 465817010567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 465817010568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 465817010569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 465817010570 Fimbrial protein; Region: Fimbrial; cl01416 465817010571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 465817010572 Fimbrial protein; Region: Fimbrial; pfam00419 465817010573 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 465817010574 PapC N-terminal domain; Region: PapC_N; pfam13954 465817010575 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 465817010576 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 465817010577 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 465817010578 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 465817010579 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 465817010580 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 465817010581 multidrug efflux system protein; Provisional; Region: PRK11431 465817010582 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 465817010583 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 465817010584 FMN-binding pocket [chemical binding]; other site 465817010585 flavin binding motif; other site 465817010586 phosphate binding motif [ion binding]; other site 465817010587 beta-alpha-beta structure motif; other site 465817010588 NAD binding pocket [chemical binding]; other site 465817010589 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 465817010590 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 465817010591 catalytic loop [active] 465817010592 iron binding site [ion binding]; other site 465817010593 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 465817010594 hydrophobic ligand binding site; other site 465817010595 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 465817010596 iron-sulfur cluster [ion binding]; other site 465817010597 [2Fe-2S] cluster binding site [ion binding]; other site 465817010598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817010599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817010600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 465817010601 dimerization interface [polypeptide binding]; other site 465817010602 Esterase/lipase [General function prediction only]; Region: COG1647 465817010603 hypothetical protein; Provisional; Region: PRK05208 465817010604 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 465817010605 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 465817010606 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 465817010607 silverDB:etchr03332 465817010608 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 465817010609 HlyD family secretion protein; Region: HlyD; pfam00529 465817010610 HlyD family secretion protein; Region: HlyD_3; pfam13437 465817010611 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 465817010612 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 465817010613 putative active site [active] 465817010614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817010615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010616 Walker A/P-loop; other site 465817010617 ATP binding site [chemical binding]; other site 465817010618 Q-loop/lid; other site 465817010619 ABC transporter signature motif; other site 465817010620 Walker B; other site 465817010621 D-loop; other site 465817010622 H-loop/switch region; other site 465817010623 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 465817010624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817010625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 465817010626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 465817010627 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 465817010628 dimerization interface [polypeptide binding]; other site 465817010629 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 465817010630 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 465817010631 FAD binding pocket [chemical binding]; other site 465817010632 FAD binding motif [chemical binding]; other site 465817010633 phosphate binding motif [ion binding]; other site 465817010634 NAD binding pocket [chemical binding]; other site 465817010635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 465817010636 Protein of unknown function, DUF482; Region: DUF482; pfam04339 465817010637 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 465817010638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 465817010639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010640 Walker A/P-loop; other site 465817010641 ATP binding site [chemical binding]; other site 465817010642 Q-loop/lid; other site 465817010643 ABC transporter signature motif; other site 465817010644 Walker B; other site 465817010645 D-loop; other site 465817010646 H-loop/switch region; other site 465817010647 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 465817010648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 465817010649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 465817010650 dimer interface [polypeptide binding]; other site 465817010651 putative CheW interface [polypeptide binding]; other site 465817010652 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 465817010653 Strictosidine synthase; Region: Str_synth; pfam03088 465817010654 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 465817010655 putative active site [active] 465817010656 putative NTP binding site [chemical binding]; other site 465817010657 putative nucleic acid binding site [nucleotide binding]; other site 465817010658 sensor protein KdpD; Provisional; Region: PRK10490 465817010659 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 465817010660 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 465817010661 Ligand Binding Site [chemical binding]; other site 465817010662 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 465817010663 GAF domain; Region: GAF_3; pfam13492 465817010664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 465817010665 dimer interface [polypeptide binding]; other site 465817010666 phosphorylation site [posttranslational modification] 465817010667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817010668 ATP binding site [chemical binding]; other site 465817010669 Mg2+ binding site [ion binding]; other site 465817010670 G-X-G motif; other site 465817010671 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 465817010672 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 465817010673 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465817010674 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 465817010675 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 465817010676 EamA-like transporter family; Region: EamA; pfam00892 465817010677 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 465817010678 EamA-like transporter family; Region: EamA; pfam00892 465817010679 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 465817010680 active site 465817010681 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 465817010682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 465817010683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 465817010684 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 465817010685 LysE type translocator; Region: LysE; pfam01810 465817010686 Domain of unknown function DUF; Region: DUF204; pfam02659 465817010687 Domain of unknown function DUF; Region: DUF204; pfam02659 465817010688 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 465817010689 magnesium-transporting ATPase; Provisional; Region: PRK15122 465817010690 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 465817010691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 465817010692 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 465817010693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817010694 motif II; other site 465817010695 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 465817010696 magnesium transport protein MgtC; Provisional; Region: PRK15385 465817010697 MgtC family; Region: MgtC; pfam02308 465817010698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817010699 metabolite-proton symporter; Region: 2A0106; TIGR00883 465817010700 putative substrate translocation pore; other site 465817010701 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 465817010702 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 465817010703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817010704 Alginate lyase; Region: Alginate_lyase; pfam05426 465817010705 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 465817010706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 465817010707 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 465817010708 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 465817010709 putative diguanylate cyclase; Provisional; Region: PRK13561 465817010710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 465817010711 metal binding site [ion binding]; metal-binding site 465817010712 active site 465817010713 I-site; other site 465817010714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 465817010715 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 465817010716 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 465817010717 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 465817010718 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 465817010719 cellulose synthase regulator protein; Provisional; Region: PRK11114 465817010720 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 465817010721 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 465817010722 DXD motif; other site 465817010723 PilZ domain; Region: PilZ; pfam07238 465817010724 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 465817010725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817010726 P-loop; other site 465817010727 Magnesium ion binding site [ion binding]; other site 465817010728 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 465817010729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817010730 Walker A/P-loop; other site 465817010731 ATP binding site [chemical binding]; other site 465817010732 Q-loop/lid; other site 465817010733 ABC transporter signature motif; other site 465817010734 Walker B; other site 465817010735 D-loop; other site 465817010736 H-loop/switch region; other site 465817010737 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 465817010738 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 465817010739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 465817010740 Walker A/P-loop; other site 465817010741 ATP binding site [chemical binding]; other site 465817010742 Q-loop/lid; other site 465817010743 ABC transporter signature motif; other site 465817010744 Walker B; other site 465817010745 D-loop; other site 465817010746 H-loop/switch region; other site 465817010747 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 465817010748 dipeptide transporter; Provisional; Region: PRK10913 465817010749 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 465817010750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010751 dimer interface [polypeptide binding]; other site 465817010752 conserved gate region; other site 465817010753 putative PBP binding loops; other site 465817010754 ABC-ATPase subunit interface; other site 465817010755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 465817010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010757 dimer interface [polypeptide binding]; other site 465817010758 conserved gate region; other site 465817010759 putative PBP binding loops; other site 465817010760 ABC-ATPase subunit interface; other site 465817010761 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 465817010762 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 465817010763 peptide binding site [polypeptide binding]; other site 465817010764 phosphoethanolamine transferase; Provisional; Region: PRK11560 465817010765 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 465817010766 Sulfatase; Region: Sulfatase; pfam00884 465817010767 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 465817010768 Transcriptional regulators [Transcription]; Region: MarR; COG1846 465817010769 MarR family; Region: MarR; pfam01047 465817010770 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 465817010771 HD domain; Region: HD_4; pfam13328 465817010772 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 465817010773 Predicted amidohydrolase [General function prediction only]; Region: COG0388 465817010774 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 465817010775 active site 465817010776 catalytic triad [active] 465817010777 dimer interface [polypeptide binding]; other site 465817010778 Isochorismatase family; Region: Isochorismatase; pfam00857 465817010779 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 465817010780 catalytic triad [active] 465817010781 conserved cis-peptide bond; other site 465817010782 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 465817010783 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 465817010784 conserved cys residue [active] 465817010785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 465817010786 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 465817010787 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 465817010788 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 465817010789 Uncharacterized conserved protein [Function unknown]; Region: COG4095 465817010790 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 465817010791 Acyltransferase family; Region: Acyl_transf_3; pfam01757 465817010792 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 465817010793 dimer interface [polypeptide binding]; other site 465817010794 motif 1; other site 465817010795 active site 465817010796 motif 2; other site 465817010797 motif 3; other site 465817010798 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 465817010799 DALR anticodon binding domain; Region: DALR_1; pfam05746 465817010800 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 465817010801 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 465817010802 putative NAD(P) binding site [chemical binding]; other site 465817010803 putative substrate binding site [chemical binding]; other site 465817010804 catalytic Zn binding site [ion binding]; other site 465817010805 structural Zn binding site [ion binding]; other site 465817010806 dimer interface [polypeptide binding]; other site 465817010807 putative transcriptional regulator; Provisional; Region: PRK10072 465817010808 non-specific DNA binding site [nucleotide binding]; other site 465817010809 salt bridge; other site 465817010810 sequence-specific DNA binding site [nucleotide binding]; other site 465817010811 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 465817010812 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 465817010813 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 465817010814 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 465817010815 active site 465817010816 P-loop; other site 465817010817 phosphorylation site [posttranslational modification] 465817010818 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 465817010819 active site 465817010820 phosphorylation site [posttranslational modification] 465817010821 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 465817010822 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 465817010823 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 465817010824 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 465817010825 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 465817010826 hypothetical protein; Provisional; Region: PRK11020 465817010827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 465817010828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817010829 DNA binding residues [nucleotide binding] 465817010830 dimerization interface [polypeptide binding]; other site 465817010831 FaeA-like protein; Region: FaeA; pfam04703 465817010832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 465817010833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 465817010834 DNA binding site [nucleotide binding] 465817010835 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 465817010836 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 465817010837 putative ligand binding site [chemical binding]; other site 465817010838 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 465817010839 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 465817010840 TM-ABC transporter signature motif; other site 465817010841 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 465817010842 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 465817010843 Walker A/P-loop; other site 465817010844 ATP binding site [chemical binding]; other site 465817010845 Q-loop/lid; other site 465817010846 ABC transporter signature motif; other site 465817010847 Walker B; other site 465817010848 D-loop; other site 465817010849 H-loop/switch region; other site 465817010850 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 465817010851 superoxide dismutase; Provisional; Region: PRK10925 465817010852 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 465817010853 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 465817010854 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 465817010855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 465817010856 inhibitor-cofactor binding pocket; inhibition site 465817010857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817010858 catalytic residue [active] 465817010859 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 465817010860 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 465817010861 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 465817010862 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 465817010863 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 465817010864 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 465817010865 putative glutathione S-transferase; Provisional; Region: PRK10357 465817010866 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465817010867 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 465817010868 dimer interface [polypeptide binding]; other site 465817010869 N-terminal domain interface [polypeptide binding]; other site 465817010870 putative substrate binding pocket (H-site) [chemical binding]; other site 465817010871 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 465817010872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 465817010873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 465817010874 DNA binding site [nucleotide binding] 465817010875 domain linker motif; other site 465817010876 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 465817010877 putative dimerization interface [polypeptide binding]; other site 465817010878 putative ligand binding site [chemical binding]; other site 465817010879 Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194 465817010880 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 465817010881 active site 465817010882 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 465817010883 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 465817010884 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 465817010885 substrate binding site [chemical binding]; other site 465817010886 ATP binding site [chemical binding]; other site 465817010887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 465817010888 D-galactonate transporter; Region: 2A0114; TIGR00893 465817010889 putative substrate translocation pore; other site 465817010890 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 465817010891 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 465817010892 dimerization interface [polypeptide binding]; other site 465817010893 ligand binding site [chemical binding]; other site 465817010894 NADP binding site [chemical binding]; other site 465817010895 catalytic site [active] 465817010896 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 465817010897 active site 465817010898 catalytic residues [active] 465817010899 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 465817010900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 465817010901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 465817010902 homodimer interface [polypeptide binding]; other site 465817010903 catalytic residue [active] 465817010904 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 465817010905 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 465817010906 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 465817010907 putative dimer interface [polypeptide binding]; other site 465817010908 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 465817010909 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 465817010910 sugar phosphate phosphatase; Provisional; Region: PRK10513 465817010911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817010912 active site 465817010913 motif I; other site 465817010914 motif II; other site 465817010915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 465817010916 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 465817010917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 465817010918 ATP binding site [chemical binding]; other site 465817010919 Mg2+ binding site [ion binding]; other site 465817010920 G-X-G motif; other site 465817010921 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 465817010922 anchoring element; other site 465817010923 dimer interface [polypeptide binding]; other site 465817010924 ATP binding site [chemical binding]; other site 465817010925 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 465817010926 active site 465817010927 putative metal-binding site [ion binding]; other site 465817010928 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 465817010929 recF protein; Region: recf; TIGR00611 465817010930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010931 Walker A/P-loop; other site 465817010932 ATP binding site [chemical binding]; other site 465817010933 Q-loop/lid; other site 465817010934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 465817010935 ABC transporter signature motif; other site 465817010936 Walker B; other site 465817010937 D-loop; other site 465817010938 H-loop/switch region; other site 465817010939 DNA polymerase III subunit beta; Validated; Region: PRK05643 465817010940 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 465817010941 putative DNA binding surface [nucleotide binding]; other site 465817010942 dimer interface [polypeptide binding]; other site 465817010943 beta-clamp/clamp loader binding surface; other site 465817010944 beta-clamp/translesion DNA polymerase binding surface; other site 465817010945 DnaA N-terminal domain; Region: DnaA_N; pfam11638 465817010946 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 465817010947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 465817010948 Walker A motif; other site 465817010949 ATP binding site [chemical binding]; other site 465817010950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 465817010951 Walker B motif; other site 465817010952 arginine finger; other site 465817010953 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 465817010954 DnaA box-binding interface [nucleotide binding]; other site 465817010955 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 465817010956 ribonuclease P; Reviewed; Region: rnpA; PRK01732 465817010957 membrane protein insertase; Provisional; Region: PRK01318 465817010958 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 465817010959 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 465817010960 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 465817010961 trmE is a tRNA modification GTPase; Region: trmE; cd04164 465817010962 G1 box; other site 465817010963 GTP/Mg2+ binding site [chemical binding]; other site 465817010964 Switch I region; other site 465817010965 G2 box; other site 465817010966 Switch II region; other site 465817010967 G3 box; other site 465817010968 G4 box; other site 465817010969 G5 box; other site 465817010970 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 465817010971 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 465817010972 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 465817010973 silverDB:etchr03446 465817010974 transcriptional regulator PhoU; Provisional; Region: PRK11115 465817010975 PhoU domain; Region: PhoU; pfam01895 465817010976 PhoU domain; Region: PhoU; pfam01895 465817010977 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 465817010978 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 465817010979 Walker A/P-loop; other site 465817010980 ATP binding site [chemical binding]; other site 465817010981 Q-loop/lid; other site 465817010982 ABC transporter signature motif; other site 465817010983 Walker B; other site 465817010984 D-loop; other site 465817010985 H-loop/switch region; other site 465817010986 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 465817010987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010988 dimer interface [polypeptide binding]; other site 465817010989 conserved gate region; other site 465817010990 putative PBP binding loops; other site 465817010991 ABC-ATPase subunit interface; other site 465817010992 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 465817010993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 465817010994 dimer interface [polypeptide binding]; other site 465817010995 conserved gate region; other site 465817010996 putative PBP binding loops; other site 465817010997 ABC-ATPase subunit interface; other site 465817010998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 465817010999 substrate binding pocket [chemical binding]; other site 465817011000 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 465817011001 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 465817011002 active site 465817011003 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 465817011004 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 465817011005 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 465817011006 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 465817011007 glutaminase active site [active] 465817011008 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 465817011009 dimer interface [polypeptide binding]; other site 465817011010 active site 465817011011 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 465817011012 dimer interface [polypeptide binding]; other site 465817011013 active site 465817011014 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 465817011015 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 465817011016 Substrate binding site; other site 465817011017 Mg++ binding site; other site 465817011018 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 465817011019 active site 465817011020 substrate binding site [chemical binding]; other site 465817011021 CoA binding site [chemical binding]; other site 465817011022 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 465817011023 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 465817011024 gamma subunit interface [polypeptide binding]; other site 465817011025 epsilon subunit interface [polypeptide binding]; other site 465817011026 LBP interface [polypeptide binding]; other site 465817011027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 465817011028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 465817011029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 465817011030 alpha subunit interaction interface [polypeptide binding]; other site 465817011031 Walker A motif; other site 465817011032 ATP binding site [chemical binding]; other site 465817011033 Walker B motif; other site 465817011034 inhibitor binding site; inhibition site 465817011035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 465817011036 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 465817011037 core domain interface [polypeptide binding]; other site 465817011038 delta subunit interface [polypeptide binding]; other site 465817011039 epsilon subunit interface [polypeptide binding]; other site 465817011040 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 465817011041 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 465817011042 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 465817011043 beta subunit interaction interface [polypeptide binding]; other site 465817011044 Walker A motif; other site 465817011045 ATP binding site [chemical binding]; other site 465817011046 Walker B motif; other site 465817011047 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 465817011048 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 465817011049 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 465817011050 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 465817011051 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 465817011052 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 465817011053 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 465817011054 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 465817011055 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 465817011056 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 465817011057 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 465817011058 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 465817011059 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 465817011060 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 465817011061 Initiator Replication protein; Region: Rep_3; pfam01051 465817011062 Helix-turn-helix domain; Region: HTH_17; pfam12728 465817011063 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 465817011064 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 465817011065 DNA methylase; Region: N6_N4_Mtase; pfam01555 465817011066 DNA methylase; Region: N6_N4_Mtase; pfam01555 465817011067 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 465817011068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 465817011069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 465817011070 ATP binding site [chemical binding]; other site 465817011071 putative Mg++ binding site [ion binding]; other site 465817011072 Uncharacterized conserved protein [Function unknown]; Region: COG2433 465817011073 MobA/MobL family; Region: MobA_MobL; pfam03389 465817011074 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 465817011075 Conjugal transfer protein TraD; Region: TraD; cl05753 465817011076 Initiator Replication protein; Region: Rep_3; pfam01051 465817011077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 465817011078 DNA binding residues [nucleotide binding] 465817011079 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817011080 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817011081 catalytic residue [active] 465817011082 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 465817011083 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 465817011084 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 465817011085 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 465817011086 Type IV secretion system proteins; Region: T4SS; pfam07996 465817011087 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 465817011088 VirB8 protein; Region: VirB8; pfam04335 465817011089 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 465817011090 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 465817011091 VirB7 interaction site; other site 465817011092 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 465817011093 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 465817011094 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011095 Walker A motif; other site 465817011096 ATP binding site [chemical binding]; other site 465817011097 Walker B motif; other site 465817011098 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 465817011099 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011100 Walker A motif; other site 465817011101 ATP binding site [chemical binding]; other site 465817011102 Walker B motif; other site 465817011103 TrbM; Region: TrbM; pfam07424 465817011104 Staphylococcal nuclease homologues; Region: SNc; smart00318 465817011105 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 465817011106 Catalytic site; other site 465817011107 DNA topoisomerase III; Provisional; Region: PRK07726 465817011108 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 465817011109 active site 465817011110 putative interdomain interaction site [polypeptide binding]; other site 465817011111 putative metal-binding site [ion binding]; other site 465817011112 putative nucleotide binding site [chemical binding]; other site 465817011113 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 465817011114 DNA binding groove [nucleotide binding] 465817011115 domain I; other site 465817011116 phosphate binding site [ion binding]; other site 465817011117 domain II; other site 465817011118 domain III; other site 465817011119 nucleotide binding site [chemical binding]; other site 465817011120 catalytic site [active] 465817011121 domain IV; other site 465817011122 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 465817011123 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 465817011124 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 465817011125 SprT homologues; Region: SprT; cl01182 465817011126 SprT-like family; Region: SprT-like; pfam10263 465817011127 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 465817011128 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 465817011129 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 465817011130 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 465817011131 conjugal transfer protein TraL; Provisional; Region: PRK13886 465817011132 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 465817011133 Initiator Replication protein; Region: Rep_3; pfam01051 465817011134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 465817011135 DNA binding residues [nucleotide binding] 465817011136 dimerization interface [polypeptide binding]; other site 465817011137 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817011138 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817011139 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 465817011140 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 465817011141 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 465817011142 Type IV secretion system proteins; Region: T4SS; pfam07996 465817011143 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 465817011144 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 465817011145 VirB8 protein; Region: VirB8; pfam04335 465817011146 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 465817011147 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 465817011148 VirB7 interaction site; other site 465817011149 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 465817011150 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 465817011151 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 465817011152 Walker A motif; other site 465817011153 hexamer interface [polypeptide binding]; other site 465817011154 ATP binding site [chemical binding]; other site 465817011155 Walker B motif; other site 465817011156 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 465817011157 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011158 Walker A motif; other site 465817011159 ATP binding site [chemical binding]; other site 465817011160 Walker B motif; other site 465817011161 TrbM; Region: TrbM; pfam07424 465817011162 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 465817011163 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 465817011164 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 465817011165 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 465817011166 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 465817011167 Type II/IV secretion system protein; Region: T2SE; pfam00437 465817011168 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011169 Walker A motif; other site 465817011170 ATP binding site [chemical binding]; other site 465817011171 Walker B motif; other site 465817011172 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 465817011173 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 465817011174 PilS N terminal; Region: PilS; pfam08805 465817011175 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011176 Walker A motif; other site 465817011177 ATP binding site [chemical binding]; other site 465817011178 Walker B motif; other site 465817011179 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 465817011180 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 465817011181 DNA topoisomerase III; Provisional; Region: PRK07726 465817011182 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 465817011183 active site 465817011184 putative interdomain interaction site [polypeptide binding]; other site 465817011185 putative metal-binding site [ion binding]; other site 465817011186 putative nucleotide binding site [chemical binding]; other site 465817011187 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 465817011188 domain I; other site 465817011189 DNA binding groove [nucleotide binding] 465817011190 phosphate binding site [ion binding]; other site 465817011191 domain II; other site 465817011192 domain III; other site 465817011193 nucleotide binding site [chemical binding]; other site 465817011194 catalytic site [active] 465817011195 domain IV; other site 465817011196 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 465817011197 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 465817011198 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 465817011199 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 465817011200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817011201 non-specific DNA binding site [nucleotide binding]; other site 465817011202 sequence-specific DNA binding site [nucleotide binding]; other site 465817011203 salt bridge; other site 465817011204 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 465817011205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 465817011206 non-specific DNA binding site [nucleotide binding]; other site 465817011207 salt bridge; other site 465817011208 sequence-specific DNA binding site [nucleotide binding]; other site 465817011209 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 465817011210 HSP70 interaction site [polypeptide binding]; other site 465817011211 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 465817011212 active site 465817011213 catalytic residues [active] 465817011214 DNA binding site [nucleotide binding] 465817011215 Int/Topo IB signature motif; other site 465817011216 ParA-like protein; Provisional; Region: PHA02518 465817011217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 465817011218 P-loop; other site 465817011219 Magnesium ion binding site [ion binding]; other site 465817011220 Myb/SANT-like DNA-binding domain; Region: Myb_DNA-bind_5; pfam13873 465817011221 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 465817011222 Domain of unknown function (DUF932); Region: DUF932; pfam06067 465817011223 Antirestriction protein (ArdA); Region: ArdA; cl01953 465817011224 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 465817011225 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 465817011226 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 465817011227 N-acetyl-D-glucosamine binding site [chemical binding]; other site 465817011228 catalytic residue [active] 465817011229 TraA; Region: TraA; cl11503 465817011230 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 465817011231 TraE protein; Region: TraE; cl05060 465817011232 conjugal transfer protein TraK; Provisional; Region: PRK13736 465817011233 TraK protein; Region: TraK; pfam06586 465817011234 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 465817011235 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 465817011236 conjugal transfer protein TraV; Provisional; Region: PRK13733 465817011237 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 465817011238 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 465817011239 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 465817011240 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 465817011241 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 465817011242 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 465817011243 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 465817011244 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 465817011245 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 465817011246 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 465817011247 F plasmid transfer operon protein; Region: TraF; pfam13728 465817011248 conjugal transfer protein TrbB; Provisional; Region: PRK13728 465817011249 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 465817011250 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 465817011251 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 465817011252 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 465817011253 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 465817011254 F sex factor protein N terminal; Region: TraD_N; pfam12615 465817011255 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 465817011256 Walker A motif; other site 465817011257 ATP binding site [chemical binding]; other site 465817011258 Walker B motif; other site 465817011259 TrwC relaxase; Region: TrwC; pfam08751 465817011260 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 465817011261 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 465817011262 AAA domain; Region: AAA_30; pfam13604 465817011263 DNA helicase TraI; Region: TraI; pfam07057 465817011264 Cornifin (SPRR) family; Region: Cornifin; pfam02389 465817011265 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 465817011266 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 465817011267 IncFII RepA protein family; Region: IncFII_repA; cl11495 465817011268 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 465817011269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 465817011270 sequence-specific DNA binding site [nucleotide binding]; other site 465817011271 salt bridge; other site 465817011272 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 465817011273 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 465817011274 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 465817011275 active site 465817011276 DNA binding site [nucleotide binding] 465817011277 Int/Topo IB signature motif; other site 465817011278 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 465817011279 Mg binding site [ion binding]; other site 465817011280 nucleotide binding site [chemical binding]; other site 465817011281 putative protofilament interface [polypeptide binding]; other site 465817011282 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 465817011283 ParB-like nuclease domain; Region: ParBc; pfam02195 465817011284 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180