-- dump date 20140619_075634 -- class Genbank::misc_feature -- table misc_feature_note -- id note 650150000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 650150000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 650150000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150000004 Walker A motif; other site 650150000005 ATP binding site [chemical binding]; other site 650150000006 Walker B motif; other site 650150000007 arginine finger; other site 650150000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 650150000009 DnaA box-binding interface [nucleotide binding]; other site 650150000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 650150000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 650150000012 putative DNA binding surface [nucleotide binding]; other site 650150000013 dimer interface [polypeptide binding]; other site 650150000014 beta-clamp/clamp loader binding surface; other site 650150000015 beta-clamp/translesion DNA polymerase binding surface; other site 650150000016 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 650150000017 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 650150000018 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 650150000019 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 650150000020 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 650150000021 putative substrate binding site [chemical binding]; other site 650150000022 putative ATP binding site [chemical binding]; other site 650150000023 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 650150000024 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000025 active site 650150000026 phosphorylation site [posttranslational modification] 650150000027 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 650150000028 active site 650150000029 P-loop; other site 650150000030 phosphorylation site [posttranslational modification] 650150000031 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 650150000032 S4 domain; Region: S4_2; pfam13275 650150000033 recombination protein F; Reviewed; Region: recF; PRK00064 650150000034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000035 Walker A/P-loop; other site 650150000036 ATP binding site [chemical binding]; other site 650150000037 Q-loop/lid; other site 650150000038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000039 ABC transporter signature motif; other site 650150000040 Walker B; other site 650150000041 D-loop; other site 650150000042 H-loop/switch region; other site 650150000043 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 650150000044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000045 ATP binding site [chemical binding]; other site 650150000046 Mg2+ binding site [ion binding]; other site 650150000047 G-X-G motif; other site 650150000048 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 650150000049 anchoring element; other site 650150000050 dimer interface [polypeptide binding]; other site 650150000051 ATP binding site [chemical binding]; other site 650150000052 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 650150000053 active site 650150000054 putative metal-binding site [ion binding]; other site 650150000055 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 650150000056 DNA gyrase subunit A; Validated; Region: PRK05560 650150000057 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 650150000058 CAP-like domain; other site 650150000059 active site 650150000060 primary dimer interface [polypeptide binding]; other site 650150000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 650150000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 650150000069 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150000070 motif 1; other site 650150000071 dimer interface [polypeptide binding]; other site 650150000072 active site 650150000073 motif 2; other site 650150000074 motif 3; other site 650150000075 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 650150000076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150000077 active site 650150000078 motif I; other site 650150000079 motif II; other site 650150000080 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 650150000081 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 650150000082 nucleoside/Zn binding site; other site 650150000083 dimer interface [polypeptide binding]; other site 650150000084 catalytic motif [active] 650150000085 Autoinducer synthetase; Region: Autoind_synth; cl17404 650150000086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000087 Coenzyme A binding pocket [chemical binding]; other site 650150000088 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 650150000089 active site 650150000090 catalytic site [active] 650150000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 650150000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150000093 Walker A motif; other site 650150000094 ATP binding site [chemical binding]; other site 650150000095 Walker B motif; other site 650150000096 arginine finger; other site 650150000097 recombination protein RecR; Reviewed; Region: recR; PRK00076 650150000098 RecR protein; Region: RecR; pfam02132 650150000099 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 650150000100 putative active site [active] 650150000101 putative metal-binding site [ion binding]; other site 650150000102 tetramer interface [polypeptide binding]; other site 650150000103 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 650150000104 putative active site [active] 650150000105 putative metal binding residues [ion binding]; other site 650150000106 signature motif; other site 650150000107 putative triphosphate binding site [ion binding]; other site 650150000108 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 650150000109 ATP-NAD kinase; Region: NAD_kinase; pfam01513 650150000110 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 650150000111 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000112 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 650150000113 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 650150000114 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 650150000115 MutS domain I; Region: MutS_I; pfam01624 650150000116 MutS domain III; Region: MutS_III; pfam05192 650150000117 MutS domain V; Region: MutS_V; pfam00488 650150000118 Walker A/P-loop; other site 650150000119 ATP binding site [chemical binding]; other site 650150000120 Q-loop/lid; other site 650150000121 ABC transporter signature motif; other site 650150000122 Walker B; other site 650150000123 D-loop; other site 650150000124 H-loop/switch region; other site 650150000125 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 650150000126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000127 ATP binding site [chemical binding]; other site 650150000128 Mg2+ binding site [ion binding]; other site 650150000129 G-X-G motif; other site 650150000130 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 650150000131 ATP binding site [chemical binding]; other site 650150000132 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 650150000133 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 650150000134 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 650150000135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150000137 Walker A/P-loop; other site 650150000138 ATP binding site [chemical binding]; other site 650150000139 Q-loop/lid; other site 650150000140 ABC transporter signature motif; other site 650150000141 Walker B; other site 650150000142 D-loop; other site 650150000143 H-loop/switch region; other site 650150000144 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 650150000145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150000146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150000147 Walker A/P-loop; other site 650150000148 ATP binding site [chemical binding]; other site 650150000149 Q-loop/lid; other site 650150000150 ABC transporter signature motif; other site 650150000151 Walker B; other site 650150000152 D-loop; other site 650150000153 H-loop/switch region; other site 650150000154 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150000155 FtsX-like permease family; Region: FtsX; pfam02687 650150000156 EDD domain protein, DegV family; Region: DegV; TIGR00762 650150000157 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 650150000158 EDD domain protein, DegV family; Region: DegV; TIGR00762 650150000159 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 650150000160 hypothetical protein; Provisional; Region: PRK11568 650150000161 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 650150000162 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 650150000163 metal binding site 2 [ion binding]; metal-binding site 650150000164 putative DNA binding helix; other site 650150000165 metal binding site 1 [ion binding]; metal-binding site 650150000166 dimer interface [polypeptide binding]; other site 650150000167 structural Zn2+ binding site [ion binding]; other site 650150000168 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 650150000169 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 650150000170 putative metal binding site [ion binding]; other site 650150000171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 650150000172 active site 650150000173 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 650150000174 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 650150000175 H+ Antiporter protein; Region: 2A0121; TIGR00900 650150000176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000177 putative substrate translocation pore; other site 650150000178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150000179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000180 non-specific DNA binding site [nucleotide binding]; other site 650150000181 salt bridge; other site 650150000182 sequence-specific DNA binding site [nucleotide binding]; other site 650150000183 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 650150000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150000185 active site 650150000186 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 650150000187 active site 650150000188 dimer interface [polypeptide binding]; other site 650150000189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150000190 active site 650150000191 Transposase; Region: HTH_Tnp_1; cl17663 650150000192 putative transposase OrfB; Reviewed; Region: PHA02517 650150000193 HTH-like domain; Region: HTH_21; pfam13276 650150000194 Integrase core domain; Region: rve; pfam00665 650150000195 Integrase core domain; Region: rve_3; pfam13683 650150000196 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 650150000197 metal-dependent hydrolase; Provisional; Region: PRK00685 650150000198 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 650150000199 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 650150000200 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 650150000201 FeoA domain; Region: FeoA; pfam04023 650150000202 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 650150000203 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 650150000204 metal binding site [ion binding]; metal-binding site 650150000205 intersubunit interface [polypeptide binding]; other site 650150000206 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 650150000207 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 650150000208 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 650150000209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 650150000210 ABC-ATPase subunit interface; other site 650150000211 dimer interface [polypeptide binding]; other site 650150000212 putative PBP binding regions; other site 650150000213 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 650150000214 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 650150000215 ABC-ATPase subunit interface; other site 650150000216 dimer interface [polypeptide binding]; other site 650150000217 putative PBP binding regions; other site 650150000218 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 650150000219 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 650150000220 active site 650150000221 Beta-lactamase; Region: Beta-lactamase; pfam00144 650150000222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 650150000223 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 650150000224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150000225 motif II; other site 650150000226 G5 domain; Region: G5; pfam07501 650150000227 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 650150000228 gamma-glutamyl kinase; Provisional; Region: PRK05429 650150000229 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 650150000230 nucleotide binding site [chemical binding]; other site 650150000231 homotetrameric interface [polypeptide binding]; other site 650150000232 putative phosphate binding site [ion binding]; other site 650150000233 putative allosteric binding site; other site 650150000234 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 650150000235 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 650150000236 putative catalytic cysteine [active] 650150000237 Sulfatase; Region: Sulfatase; cl17466 650150000238 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 650150000239 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 650150000240 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 650150000241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 650150000242 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 650150000243 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 650150000244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 650150000245 synthetase active site [active] 650150000246 NTP binding site [chemical binding]; other site 650150000247 metal binding site [ion binding]; metal-binding site 650150000248 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 650150000249 Class I aldolases; Region: Aldolase_Class_I; cl17187 650150000250 catalytic residue [active] 650150000251 Uncharacterized conserved protein [Function unknown]; Region: COG1284 650150000252 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150000253 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150000254 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 650150000255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150000256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000257 Coenzyme A binding pocket [chemical binding]; other site 650150000258 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 650150000259 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 650150000260 active site 650150000261 dimer interface [polypeptide binding]; other site 650150000262 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 650150000263 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 650150000264 active site 650150000265 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150000266 dimer interface [polypeptide binding]; other site 650150000267 substrate binding site [chemical binding]; other site 650150000268 catalytic residues [active] 650150000269 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 650150000270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150000271 motif II; other site 650150000272 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 650150000273 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 650150000274 putative ligand binding site [chemical binding]; other site 650150000275 putative NAD binding site [chemical binding]; other site 650150000276 catalytic site [active] 650150000277 RmuC family; Region: RmuC; pfam02646 650150000278 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 650150000279 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 650150000280 active site 650150000281 nucleophile elbow; other site 650150000282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 650150000283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 650150000284 active site 650150000285 catalytic tetrad [active] 650150000286 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 650150000287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150000288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150000289 motif II; other site 650150000290 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000291 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000292 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000293 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000294 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000295 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000296 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000297 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000298 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000299 Cna protein B-type domain; Region: Cna_B; pfam05738 650150000300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000301 Coenzyme A binding pocket [chemical binding]; other site 650150000302 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 650150000303 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 650150000304 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 650150000305 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 650150000306 minor groove reading motif; other site 650150000307 helix-hairpin-helix signature motif; other site 650150000308 substrate binding pocket [chemical binding]; other site 650150000309 active site 650150000310 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 650150000311 DNA binding and oxoG recognition site [nucleotide binding] 650150000312 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 650150000313 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 650150000314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 650150000315 Zn binding site [ion binding]; other site 650150000316 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 650150000317 Zn binding site [ion binding]; other site 650150000318 Transcriptional regulators [Transcription]; Region: MarR; COG1846 650150000319 MarR family; Region: MarR_2; pfam12802 650150000320 Predicted esterase [General function prediction only]; Region: COG0400 650150000321 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 650150000322 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 650150000323 homodimer interface [polypeptide binding]; other site 650150000324 catalytic residues [active] 650150000325 NAD binding site [chemical binding]; other site 650150000326 substrate binding pocket [chemical binding]; other site 650150000327 flexible flap; other site 650150000328 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 650150000329 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 650150000330 NAD binding site [chemical binding]; other site 650150000331 dimer interface [polypeptide binding]; other site 650150000332 substrate binding site [chemical binding]; other site 650150000333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150000334 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 650150000335 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 650150000336 G1 box; other site 650150000337 putative GEF interaction site [polypeptide binding]; other site 650150000338 GTP/Mg2+ binding site [chemical binding]; other site 650150000339 Switch I region; other site 650150000340 G2 box; other site 650150000341 G3 box; other site 650150000342 Switch II region; other site 650150000343 G4 box; other site 650150000344 G5 box; other site 650150000345 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 650150000346 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 650150000347 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 650150000348 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 650150000349 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 650150000350 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 650150000351 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 650150000352 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 650150000353 NAD synthetase; Provisional; Region: PRK13981 650150000354 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 650150000355 multimer interface [polypeptide binding]; other site 650150000356 active site 650150000357 catalytic triad [active] 650150000358 protein interface 1 [polypeptide binding]; other site 650150000359 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 650150000360 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150000361 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000362 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000363 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000364 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000365 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150000367 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150000368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000369 Walker A/P-loop; other site 650150000370 ATP binding site [chemical binding]; other site 650150000371 Q-loop/lid; other site 650150000372 ABC transporter signature motif; other site 650150000373 Walker B; other site 650150000374 D-loop; other site 650150000375 H-loop/switch region; other site 650150000376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150000378 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 650150000379 Walker A/P-loop; other site 650150000380 ATP binding site [chemical binding]; other site 650150000381 Q-loop/lid; other site 650150000382 ABC transporter signature motif; other site 650150000383 Walker B; other site 650150000384 D-loop; other site 650150000385 H-loop/switch region; other site 650150000386 NifU-like domain; Region: NifU; cl00484 650150000387 Divergent PAP2 family; Region: DUF212; pfam02681 650150000388 general stress protein 13; Validated; Region: PRK08059 650150000389 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 650150000390 RNA binding site [nucleotide binding]; other site 650150000391 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 650150000392 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 650150000393 active site 650150000394 dimer interface [polypeptide binding]; other site 650150000395 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 650150000396 dimer interface [polypeptide binding]; other site 650150000397 active site 650150000398 methionine sulfoxide reductase A; Provisional; Region: PRK14054 650150000399 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 650150000400 UL35; Provisional; Region: PHA03250 650150000401 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 650150000402 Transposase; Region: HTH_Tnp_1; cl17663 650150000403 putative transposase OrfB; Reviewed; Region: PHA02517 650150000404 HTH-like domain; Region: HTH_21; pfam13276 650150000405 Integrase core domain; Region: rve; pfam00665 650150000406 Integrase core domain; Region: rve_3; pfam13683 650150000407 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 650150000408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 650150000409 FeS/SAM binding site; other site 650150000410 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 650150000411 ATP cone domain; Region: ATP-cone; pfam03477 650150000412 Class III ribonucleotide reductase; Region: RNR_III; cd01675 650150000413 effector binding site; other site 650150000414 active site 650150000415 Zn binding site [ion binding]; other site 650150000416 glycine loop; other site 650150000417 Predicted transcriptional regulator [Transcription]; Region: COG3655 650150000418 non-specific DNA binding site [nucleotide binding]; other site 650150000419 salt bridge; other site 650150000420 sequence-specific DNA binding site [nucleotide binding]; other site 650150000421 Preprotein translocase SecG subunit; Region: SecG; cl09123 650150000422 ribonuclease R; Region: RNase_R; TIGR02063 650150000423 RNB domain; Region: RNB; pfam00773 650150000424 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 650150000425 RNA binding site [nucleotide binding]; other site 650150000426 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 650150000427 SmpB-tmRNA interface; other site 650150000428 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 650150000429 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 650150000430 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000431 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150000432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000433 Walker A/P-loop; other site 650150000434 ATP binding site [chemical binding]; other site 650150000435 Q-loop/lid; other site 650150000436 ABC transporter signature motif; other site 650150000437 Walker B; other site 650150000438 D-loop; other site 650150000439 H-loop/switch region; other site 650150000440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150000442 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 650150000443 Walker A/P-loop; other site 650150000444 ATP binding site [chemical binding]; other site 650150000445 Q-loop/lid; other site 650150000446 ABC transporter signature motif; other site 650150000447 Walker B; other site 650150000448 D-loop; other site 650150000449 H-loop/switch region; other site 650150000450 Uncharacterized conserved protein [Function unknown]; Region: COG1624 650150000451 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 650150000452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 650150000453 YbbR-like protein; Region: YbbR; pfam07949 650150000454 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 650150000455 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 650150000456 active site 650150000457 substrate binding site [chemical binding]; other site 650150000458 metal binding site [ion binding]; metal-binding site 650150000459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150000461 active site 650150000462 phosphorylation site [posttranslational modification] 650150000463 intermolecular recognition site; other site 650150000464 dimerization interface [polypeptide binding]; other site 650150000465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150000466 DNA binding site [nucleotide binding] 650150000467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150000468 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 650150000469 dimerization interface [polypeptide binding]; other site 650150000470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150000471 dimer interface [polypeptide binding]; other site 650150000472 phosphorylation site [posttranslational modification] 650150000473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000474 ATP binding site [chemical binding]; other site 650150000475 Mg2+ binding site [ion binding]; other site 650150000476 G-X-G motif; other site 650150000477 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 650150000478 putative metal binding site [ion binding]; other site 650150000479 Uncharacterized conserved protein [Function unknown]; Region: COG1432 650150000480 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 650150000481 Maf-like protein; Region: Maf; pfam02545 650150000482 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 650150000483 active site 650150000484 dimer interface [polypeptide binding]; other site 650150000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000486 Coenzyme A binding pocket [chemical binding]; other site 650150000487 Predicted membrane protein [Function unknown]; Region: COG4684 650150000488 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 650150000489 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 650150000490 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 650150000491 Flavoprotein; Region: Flavoprotein; pfam02441 650150000492 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 650150000493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150000496 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 650150000497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 650150000498 active site 650150000499 Family of unknown function (DUF695); Region: DUF695; pfam05117 650150000500 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 650150000501 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 650150000502 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 650150000503 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000504 active site 650150000505 phosphorylation site [posttranslational modification] 650150000506 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 650150000507 active site 650150000508 P-loop; other site 650150000509 phosphorylation site [posttranslational modification] 650150000510 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 650150000511 HTH domain; Region: HTH_11; pfam08279 650150000512 Mga helix-turn-helix domain; Region: Mga; pfam05043 650150000513 PRD domain; Region: PRD; pfam00874 650150000514 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 650150000515 active site 650150000516 P-loop; other site 650150000517 phosphorylation site [posttranslational modification] 650150000518 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000519 active site 650150000520 phosphorylation site [posttranslational modification] 650150000521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000522 putative substrate translocation pore; other site 650150000523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 650150000524 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 650150000525 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 650150000526 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 650150000527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150000528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000529 non-specific DNA binding site [nucleotide binding]; other site 650150000530 salt bridge; other site 650150000531 sequence-specific DNA binding site [nucleotide binding]; other site 650150000532 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 650150000533 23S rRNA interface [nucleotide binding]; other site 650150000534 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 650150000535 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 650150000536 core dimer interface [polypeptide binding]; other site 650150000537 peripheral dimer interface [polypeptide binding]; other site 650150000538 L10 interface [polypeptide binding]; other site 650150000539 L11 interface [polypeptide binding]; other site 650150000540 putative EF-Tu interaction site [polypeptide binding]; other site 650150000541 putative EF-G interaction site [polypeptide binding]; other site 650150000542 Methyltransferase domain; Region: Methyltransf_31; pfam13847 650150000543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150000544 S-adenosylmethionine binding site [chemical binding]; other site 650150000545 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 650150000546 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 650150000547 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 650150000548 RPB1 interaction site [polypeptide binding]; other site 650150000549 RPB10 interaction site [polypeptide binding]; other site 650150000550 RPB11 interaction site [polypeptide binding]; other site 650150000551 RPB3 interaction site [polypeptide binding]; other site 650150000552 RPB12 interaction site [polypeptide binding]; other site 650150000553 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 650150000554 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 650150000555 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 650150000556 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 650150000557 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 650150000558 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 650150000559 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 650150000560 DNA binding site [nucleotide binding] 650150000561 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 650150000562 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 650150000563 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 650150000564 active site 650150000565 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 650150000566 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 650150000567 active site 650150000568 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150000569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 650150000570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150000572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 650150000573 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 650150000574 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 650150000575 substrate binding site [chemical binding]; other site 650150000576 catalytic residues [active] 650150000577 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 650150000578 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 650150000579 dimer interface [polypeptide binding]; other site 650150000580 FMN binding site [chemical binding]; other site 650150000581 NADPH bind site [chemical binding]; other site 650150000582 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 650150000583 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 650150000584 catalytic residues [active] 650150000585 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 650150000586 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 650150000587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 650150000588 Predicted flavoprotein [General function prediction only]; Region: COG0431 650150000589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150000590 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 650150000591 putative ADP-binding pocket [chemical binding]; other site 650150000592 Chromate transporter; Region: Chromate_transp; pfam02417 650150000593 Chromate transporter; Region: Chromate_transp; pfam02417 650150000594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150000595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000596 non-specific DNA binding site [nucleotide binding]; other site 650150000597 salt bridge; other site 650150000598 sequence-specific DNA binding site [nucleotide binding]; other site 650150000599 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 650150000600 active site 650150000601 Zn binding site [ion binding]; other site 650150000602 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 650150000603 dimer interface [polypeptide binding]; other site 650150000604 catalytic triad [active] 650150000605 peroxidatic and resolving cysteines [active] 650150000606 TRAM domain; Region: TRAM; cl01282 650150000607 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 650150000608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150000609 S-adenosylmethionine binding site [chemical binding]; other site 650150000610 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 650150000611 TrkA-N domain; Region: TrkA_N; pfam02254 650150000612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 650150000613 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150000614 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 650150000615 putative nucleotide binding site [chemical binding]; other site 650150000616 putative metal binding site [ion binding]; other site 650150000617 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 650150000618 active site 650150000619 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 650150000620 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 650150000621 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 650150000622 putative active site [active] 650150000623 catalytic site [active] 650150000624 putative metal binding site [ion binding]; other site 650150000625 Penicillinase repressor; Region: Pencillinase_R; pfam03965 650150000626 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150000627 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150000628 DNA binding residues [nucleotide binding] 650150000629 Integrase core domain; Region: rve; pfam00665 650150000630 LytTr DNA-binding domain; Region: LytTR; pfam04397 650150000631 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 650150000632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000634 peroxiredoxin; Provisional; Region: PRK13189 650150000635 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 650150000636 dimer interface [polypeptide binding]; other site 650150000637 decamer (pentamer of dimers) interface [polypeptide binding]; other site 650150000638 catalytic triad [active] 650150000639 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 650150000640 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 650150000641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150000642 S-adenosylmethionine binding site [chemical binding]; other site 650150000643 Pleckstrin homology-like domain; Region: PH-like; cl17171 650150000644 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 650150000645 Restriction endonuclease; Region: Mrr_cat; pfam04471 650150000646 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 650150000647 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 650150000648 HIGH motif; other site 650150000649 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 650150000650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150000651 active site 650150000652 KMSKS motif; other site 650150000653 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 650150000654 tRNA binding surface [nucleotide binding]; other site 650150000655 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 650150000656 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 650150000657 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 650150000658 Walker A motif; other site 650150000659 ATP binding site [chemical binding]; other site 650150000660 Walker B motif; other site 650150000661 Type III pantothenate kinase; Region: Pan_kinase; cl17198 650150000662 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 650150000663 putative active site [active] 650150000664 putative metal binding site [ion binding]; other site 650150000665 Predicted transcriptional regulators [Transcription]; Region: COG1695 650150000666 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 650150000667 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 650150000668 Low molecular weight phosphatase family; Region: LMWPc; cd00115 650150000669 active site 650150000670 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 650150000671 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 650150000672 glycerol kinase; Provisional; Region: glpK; PRK00047 650150000673 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 650150000674 N- and C-terminal domain interface [polypeptide binding]; other site 650150000675 active site 650150000676 MgATP binding site [chemical binding]; other site 650150000677 catalytic site [active] 650150000678 metal binding site [ion binding]; metal-binding site 650150000679 glycerol binding site [chemical binding]; other site 650150000680 homotetramer interface [polypeptide binding]; other site 650150000681 homodimer interface [polypeptide binding]; other site 650150000682 FBP binding site [chemical binding]; other site 650150000683 protein IIAGlc interface [polypeptide binding]; other site 650150000684 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 650150000685 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 650150000686 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 650150000687 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 650150000688 Walker A/P-loop; other site 650150000689 ATP binding site [chemical binding]; other site 650150000690 Q-loop/lid; other site 650150000691 ABC transporter signature motif; other site 650150000692 Walker B; other site 650150000693 D-loop; other site 650150000694 H-loop/switch region; other site 650150000695 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 650150000696 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 650150000697 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150000698 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 650150000699 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 650150000700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150000701 Walker A/P-loop; other site 650150000702 ATP binding site [chemical binding]; other site 650150000703 Q-loop/lid; other site 650150000704 ABC transporter signature motif; other site 650150000705 Walker B; other site 650150000706 D-loop; other site 650150000707 H-loop/switch region; other site 650150000708 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 650150000709 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 650150000710 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 650150000711 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 650150000712 aspartate dehydrogenase; Region: NAD_NadX; TIGR03855 650150000713 Domain of unknown function DUF108; Region: DUF108; pfam01958 650150000714 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 650150000715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 650150000716 AMP-binding enzyme; Region: AMP-binding; pfam00501 650150000717 acyl-activating enzyme (AAE) consensus motif; other site 650150000718 AMP binding site [chemical binding]; other site 650150000719 active site 650150000720 CoA binding site [chemical binding]; other site 650150000721 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 650150000722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 650150000723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150000724 catalytic residue [active] 650150000725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 650150000726 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 650150000727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150000729 active site 650150000730 phosphorylation site [posttranslational modification] 650150000731 intermolecular recognition site; other site 650150000732 dimerization interface [polypeptide binding]; other site 650150000733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150000734 DNA binding site [nucleotide binding] 650150000735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150000736 HAMP domain; Region: HAMP; pfam00672 650150000737 dimerization interface [polypeptide binding]; other site 650150000738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150000739 dimer interface [polypeptide binding]; other site 650150000740 phosphorylation site [posttranslational modification] 650150000741 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 650150000742 ATP binding site [chemical binding]; other site 650150000743 Mg2+ binding site [ion binding]; other site 650150000744 G-X-G motif; other site 650150000745 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 650150000746 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 650150000747 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 650150000748 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 650150000749 active site 650150000750 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150000751 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150000752 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150000753 PhoU domain; Region: PhoU; pfam01895 650150000754 PhoU domain; Region: PhoU; pfam01895 650150000755 Methyltransferase domain; Region: Methyltransf_23; pfam13489 650150000756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150000757 S-adenosylmethionine binding site [chemical binding]; other site 650150000758 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 650150000759 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150000761 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150000762 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 650150000763 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG2100 650150000764 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 650150000765 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 650150000766 active site 650150000767 catalytic residues [active] 650150000768 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000769 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 650150000770 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 650150000771 active site turn [active] 650150000772 phosphorylation site [posttranslational modification] 650150000773 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 650150000774 active site 650150000775 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 650150000776 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 650150000777 active site 650150000778 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 650150000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150000780 dimer interface [polypeptide binding]; other site 650150000781 conserved gate region; other site 650150000782 ABC-ATPase subunit interface; other site 650150000783 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 650150000784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150000785 dimer interface [polypeptide binding]; other site 650150000786 conserved gate region; other site 650150000787 putative PBP binding loops; other site 650150000788 ABC-ATPase subunit interface; other site 650150000789 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150000790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 650150000791 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 650150000792 Protein of unknown function, DUF624; Region: DUF624; cl02369 650150000793 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 650150000794 Histidine kinase; Region: His_kinase; pfam06580 650150000795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000796 ATP binding site [chemical binding]; other site 650150000797 Mg2+ binding site [ion binding]; other site 650150000798 G-X-G motif; other site 650150000799 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 650150000800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150000801 active site 650150000802 phosphorylation site [posttranslational modification] 650150000803 intermolecular recognition site; other site 650150000804 dimerization interface [polypeptide binding]; other site 650150000805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000807 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 650150000808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000809 putative substrate translocation pore; other site 650150000810 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 650150000811 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 650150000812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150000813 DNA-binding site [nucleotide binding]; DNA binding site 650150000814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150000815 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 650150000816 ligand binding site [chemical binding]; other site 650150000817 dimerization interface [polypeptide binding]; other site 650150000818 Uncharacterized conserved protein [Function unknown]; Region: COG3538 650150000819 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 650150000820 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 650150000821 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 650150000822 active site 650150000823 metal binding site [ion binding]; metal-binding site 650150000824 homodimer interface [polypeptide binding]; other site 650150000825 catalytic site [active] 650150000826 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 650150000827 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 650150000828 beta-galactosidase; Region: BGL; TIGR03356 650150000829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150000831 nucleotide binding site [chemical binding]; other site 650150000832 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150000834 nucleotide binding site [chemical binding]; other site 650150000835 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 650150000836 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 650150000837 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150000838 catalytic core [active] 650150000839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 650150000840 Sterol carrier protein domain; Region: SCP2_2; pfam13530 650150000841 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150000842 putative transposase OrfB; Reviewed; Region: PHA02517 650150000843 Integrase core domain; Region: rve; pfam00665 650150000844 Integrase core domain; Region: rve_3; pfam13683 650150000845 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 650150000846 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 650150000847 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 650150000848 Double zinc ribbon; Region: DZR; pfam12773 650150000849 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 650150000850 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 650150000851 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150000852 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150000853 DNA binding residues [nucleotide binding] 650150000854 Integrase core domain; Region: rve; pfam00665 650150000855 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 650150000856 active site 650150000857 transcriptional antiterminator BglG; Provisional; Region: PRK09772 650150000858 CAT RNA binding domain; Region: CAT_RBD; smart01061 650150000859 PRD domain; Region: PRD; pfam00874 650150000860 PRD domain; Region: PRD; pfam00874 650150000861 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 650150000862 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 650150000863 putative active site cavity [active] 650150000864 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000865 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 650150000866 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 650150000867 active site turn [active] 650150000868 phosphorylation site [posttranslational modification] 650150000869 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 650150000870 HPr interaction site; other site 650150000871 glycerol kinase (GK) interaction site [polypeptide binding]; other site 650150000872 active site 650150000873 phosphorylation site [posttranslational modification] 650150000874 putative catalytic site [active] 650150000875 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 650150000876 putative metal binding site [ion binding]; other site 650150000877 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 650150000878 putative phosphate binding site [ion binding]; other site 650150000879 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 650150000880 DNA-binding site [nucleotide binding]; DNA binding site 650150000881 RNA-binding motif; other site 650150000882 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 650150000883 catalytic triad [active] 650150000884 putative active site [active] 650150000885 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 650150000886 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 650150000887 Predicted membrane protein [Function unknown]; Region: COG3212 650150000888 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 650150000889 RibD C-terminal domain; Region: RibD_C; cl17279 650150000890 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 650150000891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000893 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 650150000894 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150000895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150000896 active site 650150000897 phosphorylation site [posttranslational modification] 650150000898 intermolecular recognition site; other site 650150000899 dimerization interface [polypeptide binding]; other site 650150000900 LytTr DNA-binding domain; Region: LytTR; smart00850 650150000901 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 650150000902 Accessory gene regulator B; Region: AgrB; pfam04647 650150000903 Transposase; Region: HTH_Tnp_1; cl17663 650150000904 putative transposase OrfB; Reviewed; Region: PHA02517 650150000905 HTH-like domain; Region: HTH_21; pfam13276 650150000906 Integrase core domain; Region: rve; pfam00665 650150000907 Integrase core domain; Region: rve_3; pfam13683 650150000908 uracil transporter; Provisional; Region: PRK10720 650150000909 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 650150000910 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150000911 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 650150000912 Integrase core domain; Region: rve; pfam00665 650150000913 Integrase core domain; Region: rve_3; cl15866 650150000914 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 650150000915 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 650150000916 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 650150000917 active site 650150000918 phosphorylation site [posttranslational modification] 650150000919 Cupin domain; Region: Cupin_2; cl17218 650150000920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150000922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000923 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 650150000924 active pocket/dimerization site; other site 650150000925 active site 650150000926 phosphorylation site [posttranslational modification] 650150000927 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 650150000928 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150000929 dimer interface [polypeptide binding]; other site 650150000930 active site 650150000931 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 650150000932 Domain of unknown function DUF77; Region: DUF77; pfam01910 650150000933 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 650150000934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150000935 dimer interface [polypeptide binding]; other site 650150000936 conserved gate region; other site 650150000937 putative PBP binding loops; other site 650150000938 ABC-ATPase subunit interface; other site 650150000939 NMT1/THI5 like; Region: NMT1; pfam09084 650150000940 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 650150000941 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 650150000942 Walker A/P-loop; other site 650150000943 ATP binding site [chemical binding]; other site 650150000944 Q-loop/lid; other site 650150000945 ABC transporter signature motif; other site 650150000946 Walker B; other site 650150000947 D-loop; other site 650150000948 H-loop/switch region; other site 650150000949 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 650150000950 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 650150000951 HflX GTPase family; Region: HflX; cd01878 650150000952 G1 box; other site 650150000953 GTP/Mg2+ binding site [chemical binding]; other site 650150000954 Switch I region; other site 650150000955 G2 box; other site 650150000956 G3 box; other site 650150000957 Switch II region; other site 650150000958 G4 box; other site 650150000959 G5 box; other site 650150000960 ATP-dependent RNA helicase, pseudogene, truncated by frameshift mutation 650150000961 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 650150000962 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 650150000963 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 650150000964 catalytic site [active] 650150000965 Asp-box motif; other site 650150000966 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 650150000967 Asp-box motif; other site 650150000968 catalytic site [active] 650150000969 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 650150000970 sugar binding site [chemical binding]; other site 650150000971 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 650150000972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150000974 Coenzyme A binding pocket [chemical binding]; other site 650150000975 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150000976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150000977 RNA binding surface [nucleotide binding]; other site 650150000978 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 650150000979 probable active site [active] 650150000980 Sulphur transport; Region: Sulf_transp; pfam04143 650150000981 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 650150000982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 650150000983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150000984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 650150000985 active site residue [active] 650150000986 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 650150000987 integral membrane protein MviN; Region: mviN; TIGR01695 650150000988 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 650150000989 methionine sulfoxide reductase B; Provisional; Region: PRK00222 650150000990 SelR domain; Region: SelR; pfam01641 650150000991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150000993 active site 650150000994 phosphorylation site [posttranslational modification] 650150000995 intermolecular recognition site; other site 650150000996 dimerization interface [polypeptide binding]; other site 650150000997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150000998 DNA binding site [nucleotide binding] 650150000999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150001000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150001001 dimer interface [polypeptide binding]; other site 650150001002 phosphorylation site [posttranslational modification] 650150001003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150001004 ATP binding site [chemical binding]; other site 650150001005 Mg2+ binding site [ion binding]; other site 650150001006 G-X-G motif; other site 650150001007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150001008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150001009 active site 650150001010 phosphorylation site [posttranslational modification] 650150001011 intermolecular recognition site; other site 650150001012 dimerization interface [polypeptide binding]; other site 650150001013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150001014 DNA binding site [nucleotide binding] 650150001015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150001016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 650150001017 dimerization interface [polypeptide binding]; other site 650150001018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150001019 dimer interface [polypeptide binding]; other site 650150001020 phosphorylation site [posttranslational modification] 650150001021 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 650150001022 Predicted membrane protein [Function unknown]; Region: COG2855 650150001023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150001024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 650150001025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150001026 dimerization interface [polypeptide binding]; other site 650150001027 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150001028 Uncharacterized conserved protein [Function unknown]; Region: COG1434 650150001029 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 650150001030 putative active site [active] 650150001031 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150001032 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 650150001033 Predicted transcriptional regulators [Transcription]; Region: COG1725 650150001034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150001035 DNA-binding site [nucleotide binding]; DNA binding site 650150001036 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 650150001037 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150001038 Walker A/P-loop; other site 650150001039 ATP binding site [chemical binding]; other site 650150001040 Q-loop/lid; other site 650150001041 ABC transporter signature motif; other site 650150001042 Walker B; other site 650150001043 D-loop; other site 650150001044 H-loop/switch region; other site 650150001045 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 650150001046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001047 Walker A/P-loop; other site 650150001048 ATP binding site [chemical binding]; other site 650150001049 Q-loop/lid; other site 650150001050 ABC transporter signature motif; other site 650150001051 Walker B; other site 650150001052 D-loop; other site 650150001053 H-loop/switch region; other site 650150001054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150001055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150001056 RNA binding surface [nucleotide binding]; other site 650150001057 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 650150001058 active site 650150001059 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 650150001060 DNA-binding site [nucleotide binding]; DNA binding site 650150001061 RNA-binding motif; other site 650150001062 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150001063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150001064 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 650150001065 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 650150001066 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 650150001067 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 650150001068 putative active site [active] 650150001069 catalytic site [active] 650150001070 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 650150001071 putative active site [active] 650150001072 catalytic site [active] 650150001073 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 650150001074 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 650150001075 active site 650150001076 nucleophile elbow; other site 650150001077 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150001078 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 650150001079 active site 650150001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150001081 S-adenosylmethionine binding site [chemical binding]; other site 650150001082 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 650150001083 Part of AAA domain; Region: AAA_19; pfam13245 650150001084 Family description; Region: UvrD_C_2; pfam13538 650150001085 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 650150001086 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 650150001087 nucleotide binding pocket [chemical binding]; other site 650150001088 K-X-D-G motif; other site 650150001089 catalytic site [active] 650150001090 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 650150001091 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 650150001092 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 650150001093 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 650150001094 putative dimer interface [polypeptide binding]; other site 650150001095 Repeat domain of CamS sex pheromone cAM373 precursor and related proteins; Region: CamS_repeat; cl17505 650150001096 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 650150001097 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 650150001098 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 650150001099 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 650150001100 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 650150001101 GatB domain; Region: GatB_Yqey; smart00845 650150001102 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 650150001103 oligoendopeptidase F; Region: pepF; TIGR00181 650150001104 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 650150001105 active site 650150001106 Zn binding site [ion binding]; other site 650150001107 CoA binding domain; Region: CoA_binding_2; pfam13380 650150001108 Predicted esterase [General function prediction only]; Region: COG0400 650150001109 putative hydrolase; Provisional; Region: PRK11460 650150001110 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 650150001111 HTH domain; Region: HTH_11; pfam08279 650150001112 Mga helix-turn-helix domain; Region: Mga; pfam05043 650150001113 PRD domain; Region: PRD; pfam00874 650150001114 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 650150001115 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 650150001116 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 650150001117 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 650150001118 active site 650150001119 phosphorylation site [posttranslational modification] 650150001120 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150001121 dimer interface [polypeptide binding]; other site 650150001122 active site 650150001123 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 650150001124 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 650150001125 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 650150001126 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 650150001127 Class I ribonucleotide reductase; Region: RNR_I; cd01679 650150001128 active site 650150001129 dimer interface [polypeptide binding]; other site 650150001130 catalytic residues [active] 650150001131 effector binding site; other site 650150001132 R2 peptide binding site; other site 650150001133 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 650150001134 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 650150001135 dimer interface [polypeptide binding]; other site 650150001136 putative radical transfer pathway; other site 650150001137 diiron center [ion binding]; other site 650150001138 tyrosyl radical; other site 650150001139 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 650150001140 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 650150001141 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 650150001142 Mechanosensitive ion channel; Region: MS_channel; pfam00924 650150001143 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 650150001144 putative deacylase active site [active] 650150001145 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 650150001146 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 650150001147 Potassium binding sites [ion binding]; other site 650150001148 Cesium cation binding sites [ion binding]; other site 650150001149 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 650150001150 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 650150001151 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 650150001152 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 650150001153 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 650150001154 RNA binding site [nucleotide binding]; other site 650150001155 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 650150001156 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 650150001157 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 650150001158 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 650150001159 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 650150001160 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150001161 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 650150001162 beta subunit interaction interface [polypeptide binding]; other site 650150001163 Walker A motif; other site 650150001164 ATP binding site [chemical binding]; other site 650150001165 Walker B motif; other site 650150001166 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150001167 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 650150001168 core domain interface [polypeptide binding]; other site 650150001169 delta subunit interface [polypeptide binding]; other site 650150001170 epsilon subunit interface [polypeptide binding]; other site 650150001171 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 650150001172 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150001173 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 650150001174 alpha subunit interaction interface [polypeptide binding]; other site 650150001175 Walker A motif; other site 650150001176 ATP binding site [chemical binding]; other site 650150001177 Walker B motif; other site 650150001178 inhibitor binding site; inhibition site 650150001179 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150001180 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 650150001181 gamma subunit interface [polypeptide binding]; other site 650150001182 epsilon subunit interface [polypeptide binding]; other site 650150001183 LBP interface [polypeptide binding]; other site 650150001184 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 650150001185 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 650150001186 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 650150001187 TrkA-N domain; Region: TrkA_N; pfam02254 650150001188 TrkA-C domain; Region: TrkA_C; pfam02080 650150001189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 650150001190 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 650150001191 catalytic residues [active] 650150001192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 650150001193 active site residue [active] 650150001194 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 650150001195 putative homodimer interface [polypeptide binding]; other site 650150001196 putative homotetramer interface [polypeptide binding]; other site 650150001197 putative metal binding site [ion binding]; other site 650150001198 putative homodimer-homodimer interface [polypeptide binding]; other site 650150001199 putative allosteric switch controlling residues; other site 650150001200 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001201 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150001202 DNA binding residues [nucleotide binding] 650150001203 Integrase core domain; Region: rve; pfam00665 650150001204 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 650150001205 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 650150001206 putative active site pocket [active] 650150001207 dimerization interface [polypeptide binding]; other site 650150001208 putative catalytic residue [active] 650150001209 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 650150001210 putative substrate binding pocket [chemical binding]; other site 650150001211 AC domain interface; other site 650150001212 catalytic triad [active] 650150001213 AB domain interface; other site 650150001214 interchain disulfide; other site 650150001215 Predicted membrane protein [Function unknown]; Region: COG3817 650150001216 Protein of unknown function (DUF979); Region: DUF979; pfam06166 650150001217 Protein of unknown function (DUF969); Region: DUF969; pfam06149 650150001218 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 650150001219 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 650150001220 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 650150001221 Peptidase family M50; Region: Peptidase_M50; pfam02163 650150001222 maltose O-acetyltransferase; Provisional; Region: PRK10092 650150001223 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 650150001224 active site 650150001225 substrate binding site [chemical binding]; other site 650150001226 trimer interface [polypeptide binding]; other site 650150001227 CoA binding site [chemical binding]; other site 650150001228 PLD-like domain; Region: PLDc_2; pfam13091 650150001229 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 650150001230 putative active site [active] 650150001231 catalytic site [active] 650150001232 HI0933-like protein; Region: HI0933_like; pfam03486 650150001233 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 650150001234 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 650150001235 B3/4 domain; Region: B3_4; pfam03483 650150001236 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 650150001237 LytTr DNA-binding domain; Region: LytTR; smart00850 650150001238 endonuclease IV; Provisional; Region: PRK01060 650150001239 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 650150001240 AP (apurinic/apyrimidinic) site pocket; other site 650150001241 DNA interaction; other site 650150001242 Metal-binding active site; metal-binding site 650150001243 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 650150001244 intracellular protease, PfpI family; Region: PfpI; TIGR01382 650150001245 proposed catalytic triad [active] 650150001246 conserved cys residue [active] 650150001247 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 650150001248 Pyruvate formate lyase 1; Region: PFL1; cd01678 650150001249 coenzyme A binding site [chemical binding]; other site 650150001250 active site 650150001251 catalytic residues [active] 650150001252 glycine loop; other site 650150001253 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 650150001254 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 650150001255 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 650150001256 NAD binding site [chemical binding]; other site 650150001257 sugar binding site [chemical binding]; other site 650150001258 divalent metal binding site [ion binding]; other site 650150001259 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150001260 dimer interface [polypeptide binding]; other site 650150001261 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 650150001262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150001263 active site 650150001264 motif I; other site 650150001265 motif II; other site 650150001266 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 650150001267 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150001268 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 650150001269 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 650150001270 putative active site [active] 650150001271 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 650150001272 DHHW protein; Region: DHHW; pfam14286 650150001273 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 650150001274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001275 catalytic residue [active] 650150001276 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 650150001277 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150001278 active site 650150001279 metal-binding site 650150001280 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 650150001281 Bacterial sugar transferase; Region: Bac_transf; pfam02397 650150001282 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 650150001283 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 650150001284 Bacterial SH3 domain; Region: SH3_3; pfam08239 650150001285 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150001286 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 650150001287 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 650150001288 active site 650150001289 Zn binding site [ion binding]; other site 650150001290 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 650150001291 zinc binding site [ion binding]; other site 650150001292 putative ligand binding site [chemical binding]; other site 650150001293 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 650150001294 zinc binding site [ion binding]; other site 650150001295 putative ligand binding site [chemical binding]; other site 650150001296 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 650150001297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150001298 TM-ABC transporter signature motif; other site 650150001299 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 650150001300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001301 Walker A/P-loop; other site 650150001302 ATP binding site [chemical binding]; other site 650150001303 Q-loop/lid; other site 650150001304 ABC transporter signature motif; other site 650150001305 Walker B; other site 650150001306 D-loop; other site 650150001307 H-loop/switch region; other site 650150001308 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 650150001309 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 650150001310 Walker A/P-loop; other site 650150001311 ATP binding site [chemical binding]; other site 650150001312 Q-loop/lid; other site 650150001313 ABC transporter signature motif; other site 650150001314 Walker B; other site 650150001315 D-loop; other site 650150001316 H-loop/switch region; other site 650150001317 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 650150001318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150001319 dimer interface [polypeptide binding]; other site 650150001320 conserved gate region; other site 650150001321 putative PBP binding loops; other site 650150001322 ABC-ATPase subunit interface; other site 650150001323 ABC transporter, permease protein, pseudogene, truncated by premature stop codon 650150001324 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150001325 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 650150001326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150001327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 650150001328 Predicted transcriptional regulator [Transcription]; Region: COG2378 650150001329 Transcriptional regulator; Region: Rrf2; cl17282 650150001330 WYL domain; Region: WYL; pfam13280 650150001331 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 650150001332 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 650150001333 Substrate-binding site [chemical binding]; other site 650150001334 Substrate specificity [chemical binding]; other site 650150001335 serine O-acetyltransferase; Region: cysE; TIGR01172 650150001336 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 650150001337 trimer interface [polypeptide binding]; other site 650150001338 active site 650150001339 substrate binding site [chemical binding]; other site 650150001340 CoA binding site [chemical binding]; other site 650150001341 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001342 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150001343 DNA binding residues [nucleotide binding] 650150001344 Integrase core domain; Region: rve; pfam00665 650150001345 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 650150001346 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 650150001347 GDP-binding site [chemical binding]; other site 650150001348 ACT binding site; other site 650150001349 IMP binding site; other site 650150001350 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 650150001351 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 650150001352 active site 650150001353 metal binding site [ion binding]; metal-binding site 650150001354 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 650150001355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001358 Walker A/P-loop; other site 650150001359 ATP binding site [chemical binding]; other site 650150001360 Q-loop/lid; other site 650150001361 ABC transporter signature motif; other site 650150001362 Walker B; other site 650150001363 D-loop; other site 650150001364 H-loop/switch region; other site 650150001365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150001367 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 650150001368 Walker A/P-loop; other site 650150001369 ATP binding site [chemical binding]; other site 650150001370 Q-loop/lid; other site 650150001371 ABC transporter signature motif; other site 650150001372 Walker B; other site 650150001373 D-loop; other site 650150001374 H-loop/switch region; other site 650150001375 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150001376 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 650150001377 oligomer interface [polypeptide binding]; other site 650150001378 active site 650150001379 metal binding site [ion binding]; metal-binding site 650150001380 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 650150001381 hydrophobic ligand binding site; other site 650150001382 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 650150001383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150001384 DNA-binding site [nucleotide binding]; DNA binding site 650150001385 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 650150001386 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 650150001387 active site 650150001388 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 650150001389 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 650150001390 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 650150001391 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 650150001392 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 650150001393 active site 650150001394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001395 catalytic core [active] 650150001396 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 650150001397 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 650150001398 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 650150001399 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 650150001400 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 650150001401 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 650150001402 tetramer interface [polypeptide binding]; other site 650150001403 TPP-binding site [chemical binding]; other site 650150001404 heterodimer interface [polypeptide binding]; other site 650150001405 phosphorylation loop region [posttranslational modification] 650150001406 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 650150001407 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 650150001408 alpha subunit interface [polypeptide binding]; other site 650150001409 TPP binding site [chemical binding]; other site 650150001410 heterodimer interface [polypeptide binding]; other site 650150001411 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150001412 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 650150001413 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150001414 E3 interaction surface; other site 650150001415 lipoyl attachment site [posttranslational modification]; other site 650150001416 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150001417 E3 interaction surface; other site 650150001418 lipoyl attachment site [posttranslational modification]; other site 650150001419 e3 binding domain; Region: E3_binding; pfam02817 650150001420 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 650150001421 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 650150001422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 650150001423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 650150001424 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150001425 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 650150001426 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 650150001427 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 650150001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150001429 dimer interface [polypeptide binding]; other site 650150001430 conserved gate region; other site 650150001431 putative PBP binding loops; other site 650150001432 ABC-ATPase subunit interface; other site 650150001433 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 650150001434 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 650150001435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 650150001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150001437 dimer interface [polypeptide binding]; other site 650150001438 conserved gate region; other site 650150001439 putative PBP binding loops; other site 650150001440 ABC-ATPase subunit interface; other site 650150001441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001442 Walker A/P-loop; other site 650150001443 ATP binding site [chemical binding]; other site 650150001444 Q-loop/lid; other site 650150001445 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 650150001446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 650150001447 Q-loop/lid; other site 650150001448 ABC transporter signature motif; other site 650150001449 Walker B; other site 650150001450 D-loop; other site 650150001451 H-loop/switch region; other site 650150001452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 650150001453 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 650150001454 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 650150001455 Walker A/P-loop; other site 650150001456 ATP binding site [chemical binding]; other site 650150001457 Q-loop/lid; other site 650150001458 ABC transporter signature motif; other site 650150001459 Walker B; other site 650150001460 D-loop; other site 650150001461 H-loop/switch region; other site 650150001462 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 650150001463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 650150001464 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 650150001465 non-specific DNA interactions [nucleotide binding]; other site 650150001466 DNA binding site [nucleotide binding] 650150001467 sequence specific DNA binding site [nucleotide binding]; other site 650150001468 putative cAMP binding site [chemical binding]; other site 650150001469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150001471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001472 Walker A/P-loop; other site 650150001473 ATP binding site [chemical binding]; other site 650150001474 Q-loop/lid; other site 650150001475 ABC transporter signature motif; other site 650150001476 Walker B; other site 650150001477 D-loop; other site 650150001478 H-loop/switch region; other site 650150001479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150001481 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 650150001482 Walker A/P-loop; other site 650150001483 ATP binding site [chemical binding]; other site 650150001484 Q-loop/lid; other site 650150001485 ABC transporter signature motif; other site 650150001486 Walker B; other site 650150001487 D-loop; other site 650150001488 H-loop/switch region; other site 650150001489 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 650150001490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150001491 active site 650150001492 motif I; other site 650150001493 motif II; other site 650150001494 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 650150001495 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 650150001496 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 650150001497 DRTGG domain; Region: DRTGG; pfam07085 650150001498 CBS domain; Region: CBS; pfam00571 650150001499 DHH family; Region: DHH; pfam01368 650150001500 DHHA2 domain; Region: DHHA2; pfam02833 650150001501 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 650150001502 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 650150001503 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 650150001504 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 650150001505 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 650150001506 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 650150001507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001508 catalytic core [active] 650150001509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001510 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 650150001511 dimer interface [polypeptide binding]; other site 650150001512 FMN binding site [chemical binding]; other site 650150001513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 650150001514 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 650150001515 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 650150001516 glutaminase active site [active] 650150001517 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150001518 dimer interface [polypeptide binding]; other site 650150001519 active site 650150001520 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 650150001521 dimer interface [polypeptide binding]; other site 650150001522 active site 650150001523 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001524 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150001525 DNA binding residues [nucleotide binding] 650150001526 Integrase core domain; Region: rve; pfam00665 650150001527 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 650150001528 trimer interface [polypeptide binding]; other site 650150001529 active site 650150001530 G bulge; other site 650150001531 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 650150001532 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 650150001533 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 650150001534 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 650150001535 active site 650150001536 NTP binding site [chemical binding]; other site 650150001537 metal binding triad [ion binding]; metal-binding site 650150001538 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150001539 Zn2+ binding site [ion binding]; other site 650150001540 Mg2+ binding site [ion binding]; other site 650150001541 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150001542 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150001543 Walker A/P-loop; other site 650150001544 ATP binding site [chemical binding]; other site 650150001545 Q-loop/lid; other site 650150001546 ABC transporter signature motif; other site 650150001547 Walker B; other site 650150001548 D-loop; other site 650150001549 H-loop/switch region; other site 650150001550 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 650150001551 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150001552 FtsX-like permease family; Region: FtsX; pfam02687 650150001553 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150001554 FtsX-like permease family; Region: FtsX; pfam02687 650150001555 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 650150001556 Domain of unknown function DUF21; Region: DUF21; pfam01595 650150001557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 650150001558 Transporter associated domain; Region: CorC_HlyC; pfam03471 650150001559 Rrf2 family protein; Region: rrf2_super; TIGR00738 650150001560 Transcriptional regulator; Region: Rrf2; pfam02082 650150001561 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 650150001562 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 650150001563 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 650150001564 dimer interface [polypeptide binding]; other site 650150001565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150001566 catalytic residue [active] 650150001567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150001568 DNA-binding site [nucleotide binding]; DNA binding site 650150001569 TrkA-C domain; Region: TrkA_C; pfam02080 650150001570 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 650150001571 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 650150001572 motif 1; other site 650150001573 active site 650150001574 motif 2; other site 650150001575 motif 3; other site 650150001576 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 650150001577 DHHA1 domain; Region: DHHA1; pfam02272 650150001578 hypothetical protein; Provisional; Region: PRK05473 650150001579 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 650150001580 hypothetical protein; Provisional; Region: PRK13678 650150001581 YceG-like family; Region: YceG; pfam02618 650150001582 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 650150001583 dimerization interface [polypeptide binding]; other site 650150001584 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 650150001585 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 650150001586 Sugar specificity; other site 650150001587 Pyrimidine base specificity; other site 650150001588 ATP-binding site [chemical binding]; other site 650150001589 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 650150001590 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 650150001591 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 650150001592 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 650150001593 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 650150001594 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 650150001595 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 650150001596 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150001597 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 650150001598 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 650150001599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 650150001600 DNA binding residues [nucleotide binding] 650150001601 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 650150001602 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 650150001603 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 650150001604 putative active site [active] 650150001605 substrate binding site [chemical binding]; other site 650150001606 putative cosubstrate binding site; other site 650150001607 catalytic site [active] 650150001608 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 650150001609 substrate binding site [chemical binding]; other site 650150001610 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 650150001611 GTP-binding protein LepA; Provisional; Region: PRK05433 650150001612 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 650150001613 G1 box; other site 650150001614 putative GEF interaction site [polypeptide binding]; other site 650150001615 GTP/Mg2+ binding site [chemical binding]; other site 650150001616 Switch I region; other site 650150001617 G2 box; other site 650150001618 G3 box; other site 650150001619 Switch II region; other site 650150001620 G4 box; other site 650150001621 G5 box; other site 650150001622 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 650150001623 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 650150001624 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 650150001625 Predicted pyrophosphatase [General function prediction only]; Region: MazG; COG1694 650150001626 metal binding site [ion binding]; metal-binding site 650150001627 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 650150001628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 650150001629 FeS/SAM binding site; other site 650150001630 HemN C-terminal domain; Region: HemN_C; pfam06969 650150001631 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 650150001632 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 650150001633 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 650150001634 16S/18S rRNA binding site [nucleotide binding]; other site 650150001635 S13e-L30e interaction site [polypeptide binding]; other site 650150001636 25S rRNA binding site [nucleotide binding]; other site 650150001637 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 650150001638 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 650150001639 RNase E interface [polypeptide binding]; other site 650150001640 trimer interface [polypeptide binding]; other site 650150001641 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 650150001642 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 650150001643 RNase E interface [polypeptide binding]; other site 650150001644 trimer interface [polypeptide binding]; other site 650150001645 active site 650150001646 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 650150001647 putative nucleic acid binding region [nucleotide binding]; other site 650150001648 G-X-X-G motif; other site 650150001649 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 650150001650 RNA binding site [nucleotide binding]; other site 650150001651 domain interface; other site 650150001652 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 650150001653 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 650150001654 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 650150001655 HIT family signature motif; other site 650150001656 catalytic residue [active] 650150001657 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 650150001658 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 650150001659 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 650150001660 FeS assembly ATPase SufC; Region: sufC; TIGR01978 650150001661 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 650150001662 Walker A/P-loop; other site 650150001663 ATP binding site [chemical binding]; other site 650150001664 Q-loop/lid; other site 650150001665 ABC transporter signature motif; other site 650150001666 Walker B; other site 650150001667 D-loop; other site 650150001668 H-loop/switch region; other site 650150001669 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 650150001670 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 650150001671 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 650150001672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001673 catalytic residue [active] 650150001674 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 650150001675 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 650150001676 trimerization site [polypeptide binding]; other site 650150001677 active site 650150001678 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 650150001679 FeS assembly protein SufB; Region: sufB; TIGR01980 650150001680 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 650150001681 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 650150001682 sugar efflux transporter; Region: 2A0120; TIGR00899 650150001683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150001684 putative substrate translocation pore; other site 650150001685 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 650150001686 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 650150001687 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 650150001688 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 650150001689 active site 650150001690 HIGH motif; other site 650150001691 dimer interface [polypeptide binding]; other site 650150001692 KMSKS motif; other site 650150001693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150001694 RNA binding surface [nucleotide binding]; other site 650150001695 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 650150001696 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 650150001697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150001698 RNA binding surface [nucleotide binding]; other site 650150001699 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 650150001700 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 650150001701 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 650150001702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001703 catalytic residue [active] 650150001704 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 650150001705 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 650150001706 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 650150001707 Ligand Binding Site [chemical binding]; other site 650150001708 signal recognition particle protein; Provisional; Region: PRK10867 650150001709 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 650150001710 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 650150001711 P loop; other site 650150001712 GTP binding site [chemical binding]; other site 650150001713 Signal peptide binding domain; Region: SRP_SPB; pfam02978 650150001714 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 650150001715 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 650150001716 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 650150001717 Catalytic site [active] 650150001718 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 650150001719 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 650150001720 GTP/Mg2+ binding site [chemical binding]; other site 650150001721 G4 box; other site 650150001722 G5 box; other site 650150001723 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 650150001724 G1 box; other site 650150001725 G1 box; other site 650150001726 GTP/Mg2+ binding site [chemical binding]; other site 650150001727 G2 box; other site 650150001728 Switch I region; other site 650150001729 Switch I region; other site 650150001730 G2 box; other site 650150001731 G3 box; other site 650150001732 G3 box; other site 650150001733 Switch II region; other site 650150001734 Switch II region; other site 650150001735 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 650150001736 RNA/DNA hybrid binding site [nucleotide binding]; other site 650150001737 active site 650150001738 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 650150001739 DNA protecting protein DprA; Region: dprA; TIGR00732 650150001740 DNA topoisomerase I; Validated; Region: PRK05582 650150001741 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 650150001742 active site 650150001743 interdomain interaction site; other site 650150001744 putative metal-binding site [ion binding]; other site 650150001745 nucleotide binding site [chemical binding]; other site 650150001746 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 650150001747 domain I; other site 650150001748 DNA binding groove [nucleotide binding] 650150001749 phosphate binding site [ion binding]; other site 650150001750 domain II; other site 650150001751 domain III; other site 650150001752 nucleotide binding site [chemical binding]; other site 650150001753 catalytic site [active] 650150001754 domain IV; other site 650150001755 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 650150001756 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 650150001757 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 650150001758 Glucose inhibited division protein A; Region: GIDA; pfam01134 650150001759 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 650150001760 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 650150001761 active site 650150001762 DNA binding site [nucleotide binding] 650150001763 Int/Topo IB signature motif; other site 650150001764 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 650150001765 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 650150001766 Transcriptional regulator [Transcription]; Region: LytR; COG1316 650150001767 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 650150001768 FAD binding domain; Region: FAD_binding_4; pfam01565 650150001769 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 650150001770 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 650150001771 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 650150001772 cell division protein MraZ; Reviewed; Region: PRK00326 650150001773 MraZ protein; Region: MraZ; pfam02381 650150001774 MraZ protein; Region: MraZ; pfam02381 650150001775 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 650150001776 MraW methylase family; Region: Methyltransf_5; cl17771 650150001777 Cell division protein FtsL; Region: FtsL; cl11433 650150001778 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 650150001779 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150001780 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 650150001781 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 650150001782 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 650150001783 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 650150001784 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 650150001785 Mg++ binding site [ion binding]; other site 650150001786 putative catalytic motif [active] 650150001787 putative substrate binding site [chemical binding]; other site 650150001788 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 650150001789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150001791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150001792 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 650150001793 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 650150001794 DHH family; Region: DHH; pfam01368 650150001795 DHHA1 domain; Region: DHHA1; pfam02272 650150001796 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 650150001797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150001798 active site 650150001799 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 650150001800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150001801 Zn2+ binding site [ion binding]; other site 650150001802 Mg2+ binding site [ion binding]; other site 650150001803 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 650150001804 synthetase active site [active] 650150001805 NTP binding site [chemical binding]; other site 650150001806 metal binding site [ion binding]; metal-binding site 650150001807 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 650150001808 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 650150001809 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 650150001810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 650150001811 dimer interface [polypeptide binding]; other site 650150001812 motif 1; other site 650150001813 active site 650150001814 motif 2; other site 650150001815 motif 3; other site 650150001816 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 650150001817 anticodon binding site; other site 650150001818 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 650150001819 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 650150001820 dimer interface [polypeptide binding]; other site 650150001821 anticodon binding site; other site 650150001822 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150001823 motif 1; other site 650150001824 dimer interface [polypeptide binding]; other site 650150001825 active site 650150001826 motif 2; other site 650150001827 GAD domain; Region: GAD; pfam02938 650150001828 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150001829 active site 650150001830 motif 3; other site 650150001831 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 650150001832 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 650150001833 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 650150001834 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 650150001835 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 650150001836 23S rRNA binding site [nucleotide binding]; other site 650150001837 L21 binding site [polypeptide binding]; other site 650150001838 L13 binding site [polypeptide binding]; other site 650150001839 MarR family; Region: MarR; pfam01047 650150001840 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 650150001841 Phosphotransferase enzyme family; Region: APH; pfam01636 650150001842 active site 650150001843 substrate binding site [chemical binding]; other site 650150001844 ATP binding site [chemical binding]; other site 650150001845 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 650150001846 active site 650150001847 dimerization interface [polypeptide binding]; other site 650150001848 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 650150001849 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 650150001850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 650150001851 homotrimer interaction site [polypeptide binding]; other site 650150001852 putative active site [active] 650150001853 Uncharacterized conserved protein [Function unknown]; Region: COG1284 650150001854 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150001855 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150001856 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 650150001857 S-adenosylmethionine synthetase; Validated; Region: PRK05250 650150001858 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 650150001859 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 650150001860 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 650150001861 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 650150001862 hypothetical protein; Provisional; Region: PRK13670 650150001863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150001864 S-adenosylmethionine binding site [chemical binding]; other site 650150001865 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150001866 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 650150001867 oligomer interface [polypeptide binding]; other site 650150001868 active site 650150001869 metal binding site [ion binding]; metal-binding site 650150001870 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 650150001871 putative active site [active] 650150001872 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 650150001873 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150001874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150001875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150001876 catabolite control protein A; Region: ccpA; TIGR01481 650150001877 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150001878 DNA binding site [nucleotide binding] 650150001879 domain linker motif; other site 650150001880 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 650150001881 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 650150001882 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 650150001883 putative active site [active] 650150001884 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 650150001885 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 650150001886 nudix motif; other site 650150001887 Methyltransferase domain; Region: Methyltransf_31; pfam13847 650150001888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150001889 S-adenosylmethionine binding site [chemical binding]; other site 650150001890 phosphodiesterase YaeI; Provisional; Region: PRK11340 650150001891 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 650150001892 active site 650150001893 metal binding site [ion binding]; metal-binding site 650150001894 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150001895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 650150001896 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 650150001897 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 650150001898 active site 650150001899 catalytic residues [active] 650150001900 metal binding site [ion binding]; metal-binding site 650150001901 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 650150001902 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 650150001903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150001904 S-adenosylmethionine binding site [chemical binding]; other site 650150001905 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 650150001906 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 650150001907 GrpE; Region: GrpE; pfam01025 650150001908 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 650150001909 dimer interface [polypeptide binding]; other site 650150001910 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 650150001911 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 650150001912 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 650150001913 nucleotide binding site [chemical binding]; other site 650150001914 NEF interaction site [polypeptide binding]; other site 650150001915 SBD interface [polypeptide binding]; other site 650150001916 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 650150001917 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 650150001918 HSP70 interaction site [polypeptide binding]; other site 650150001919 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 650150001920 Zn binding sites [ion binding]; other site 650150001921 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 650150001922 dimer interface [polypeptide binding]; other site 650150001923 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 650150001924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150001925 Walker A motif; other site 650150001926 ATP binding site [chemical binding]; other site 650150001927 Walker B motif; other site 650150001928 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 650150001929 arginine finger; other site 650150001930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150001931 Walker A motif; other site 650150001932 ATP binding site [chemical binding]; other site 650150001933 Walker B motif; other site 650150001934 arginine finger; other site 650150001935 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 650150001936 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 650150001937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150001938 Coenzyme A binding pocket [chemical binding]; other site 650150001939 CAAX protease self-immunity; Region: Abi; pfam02517 650150001940 AMP deaminase; Provisional; Region: PTZ00310 650150001941 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 650150001942 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 650150001943 bacteriophage 650150001944 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 650150001945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 650150001946 active site 650150001947 DNA binding site [nucleotide binding] 650150001948 Int/Topo IB signature motif; other site 650150001949 Abi-like protein; Region: Abi_2; pfam07751 650150001950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150001951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150001952 non-specific DNA binding site [nucleotide binding]; other site 650150001953 salt bridge; other site 650150001954 sequence-specific DNA binding site [nucleotide binding]; other site 650150001955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150001956 non-specific DNA binding site [nucleotide binding]; other site 650150001957 salt bridge; other site 650150001958 sequence-specific DNA binding site [nucleotide binding]; other site 650150001959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150001960 AAA domain; Region: AAA_23; pfam13476 650150001961 Walker A/P-loop; other site 650150001962 ATP binding site [chemical binding]; other site 650150001963 AAA domain; Region: AAA_24; pfam13479 650150001964 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 650150001965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150001966 ATP binding site [chemical binding]; other site 650150001967 putative Mg++ binding site [ion binding]; other site 650150001968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150001969 nucleotide binding region [chemical binding]; other site 650150001970 ATP-binding site [chemical binding]; other site 650150001971 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 650150001972 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 650150001973 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 650150001974 Walker A motif; other site 650150001975 ATP binding site [chemical binding]; other site 650150001976 Walker B motif; other site 650150001977 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 650150001978 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 650150001979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 650150001980 Terminase-like family; Region: Terminase_6; pfam03237 650150001981 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 650150001982 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 650150001983 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 650150001984 14-3-3 domain; Region: 14-3-3; cl02098 650150001985 dimer interface [polypeptide binding]; other site 650150001986 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 650150001987 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 650150001988 active site 650150001989 conformational flexibility of ligand binding pocket; other site 650150001990 ADP-ribosylating toxin turn-turn motif; other site 650150001991 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 650150001992 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 650150001993 Phage major tail protein 2; Region: Phage_tail_2; cl11463 650150001994 tape measure domain; Region: tape_meas_nterm; TIGR02675 650150001995 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 650150001996 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 650150001997 CHAP domain; Region: CHAP; cl17642 650150001998 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 650150001999 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 650150002000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150002001 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 650150002002 putative ADP-binding pocket [chemical binding]; other site 650150002003 RecX family; Region: RecX; cl00936 650150002004 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 650150002005 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 650150002006 generic binding surface I; other site 650150002007 generic binding surface II; other site 650150002008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150002009 Zn2+ binding site [ion binding]; other site 650150002010 Mg2+ binding site [ion binding]; other site 650150002011 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 650150002012 KH domain; Region: KH_4; pfam13083 650150002013 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 650150002014 RimM N-terminal domain; Region: RimM; pfam01782 650150002015 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 650150002016 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002017 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150002018 DNA binding residues [nucleotide binding] 650150002019 Integrase core domain; Region: rve; pfam00665 650150002020 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 650150002021 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 650150002022 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 650150002023 aspartate aminotransferase; Provisional; Region: PRK05764 650150002024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150002025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150002026 homodimer interface [polypeptide binding]; other site 650150002027 catalytic residue [active] 650150002028 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 650150002029 rRNA interaction site [nucleotide binding]; other site 650150002030 S8 interaction site; other site 650150002031 putative laminin-1 binding site; other site 650150002032 elongation factor Ts; Provisional; Region: tsf; PRK09377 650150002033 UBA/TS-N domain; Region: UBA; pfam00627 650150002034 Elongation factor TS; Region: EF_TS; pfam00889 650150002035 Elongation factor TS; Region: EF_TS; pfam00889 650150002036 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 650150002037 putative nucleotide binding site [chemical binding]; other site 650150002038 uridine monophosphate binding site [chemical binding]; other site 650150002039 homohexameric interface [polypeptide binding]; other site 650150002040 ribosome recycling factor; Reviewed; Region: frr; PRK00083 650150002041 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 650150002042 hinge region; other site 650150002043 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 650150002044 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 650150002045 catalytic residue [active] 650150002046 putative FPP diphosphate binding site; other site 650150002047 putative FPP binding hydrophobic cleft; other site 650150002048 dimer interface [polypeptide binding]; other site 650150002049 putative IPP diphosphate binding site; other site 650150002050 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 650150002051 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 650150002052 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 650150002053 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 650150002054 active site 650150002055 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 650150002056 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 650150002057 putative substrate binding region [chemical binding]; other site 650150002058 replicative DNA helicase; Provisional; Region: PRK09165 650150002059 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 650150002060 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 650150002061 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 650150002062 Dockerin type I repeat; Region: Dockerin_1; pfam00404 650150002063 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 650150002064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 650150002065 endonuclease III; Region: ENDO3c; smart00478 650150002066 minor groove reading motif; other site 650150002067 helix-hairpin-helix signature motif; other site 650150002068 substrate binding pocket [chemical binding]; other site 650150002069 active site 650150002070 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 650150002071 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150002072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150002073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150002074 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 650150002075 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 650150002076 ATP-grasp domain; Region: ATP-grasp_4; cl17255 650150002077 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 650150002078 alanine racemase; Reviewed; Region: alr; PRK00053 650150002079 active site 650150002080 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150002081 dimer interface [polypeptide binding]; other site 650150002082 substrate binding site [chemical binding]; other site 650150002083 catalytic residues [active] 650150002084 Transglycosylase; Region: Transgly; pfam00912 650150002085 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 650150002086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 650150002087 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 650150002088 cell division protein GpsB; Provisional; Region: PRK14127 650150002089 DivIVA domain; Region: DivI1A_domain; TIGR03544 650150002090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150002091 non-specific DNA binding site [nucleotide binding]; other site 650150002092 salt bridge; other site 650150002093 sequence-specific DNA binding site [nucleotide binding]; other site 650150002094 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 650150002095 recombinase A; Provisional; Region: recA; PRK09354 650150002096 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 650150002097 hexamer interface [polypeptide binding]; other site 650150002098 Walker A motif; other site 650150002099 ATP binding site [chemical binding]; other site 650150002100 Walker B motif; other site 650150002101 phosphodiesterase; Provisional; Region: PRK12704 650150002102 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150002103 Zn2+ binding site [ion binding]; other site 650150002104 Mg2+ binding site [ion binding]; other site 650150002105 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 650150002106 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 650150002107 putative active site [active] 650150002108 metal binding site [ion binding]; metal-binding site 650150002109 homodimer binding site [polypeptide binding]; other site 650150002110 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150002111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 650150002112 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 650150002113 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 650150002114 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 650150002115 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 650150002116 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 650150002117 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002118 domain interaction interfaces [polypeptide binding]; other site 650150002119 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002120 domain interaction interfaces [polypeptide binding]; other site 650150002121 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002122 domain interaction interfaces [polypeptide binding]; other site 650150002123 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002124 domain interaction interfaces [polypeptide binding]; other site 650150002125 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002126 domain interaction interfaces [polypeptide binding]; other site 650150002127 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002128 domain interaction interfaces [polypeptide binding]; other site 650150002129 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002130 domain interaction interfaces [polypeptide binding]; other site 650150002131 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002132 domain interaction interfaces [polypeptide binding]; other site 650150002133 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002134 domain interaction interfaces [polypeptide binding]; other site 650150002135 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002136 domain interaction interfaces [polypeptide binding]; other site 650150002137 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002138 domain interaction interfaces [polypeptide binding]; other site 650150002139 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002140 domain interaction interfaces [polypeptide binding]; other site 650150002141 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002142 domain interaction interfaces [polypeptide binding]; other site 650150002143 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002144 domain interaction interfaces [polypeptide binding]; other site 650150002145 Collagen binding domain; Region: Collagen_bind; pfam05737 650150002146 Cna protein B-type domain; Region: Cna_B; pfam05738 650150002147 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002148 domain interaction interfaces [polypeptide binding]; other site 650150002149 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002150 domain interaction interfaces [polypeptide binding]; other site 650150002151 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150002152 domain interaction interfaces [polypeptide binding]; other site 650150002153 prolyl-tRNA synthetase; Provisional; Region: PRK09194 650150002154 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 650150002155 dimer interface [polypeptide binding]; other site 650150002156 motif 1; other site 650150002157 active site 650150002158 motif 2; other site 650150002159 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 650150002160 putative deacylase active site [active] 650150002161 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150002162 active site 650150002163 motif 3; other site 650150002164 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 650150002165 anticodon binding site; other site 650150002166 hypothetical protein; Provisional; Region: PRK00523 650150002167 glycosyl transferase, family 51, pseudogene, truncated by frameshift mutation 650150002168 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 650150002169 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 650150002170 active site 650150002171 HIGH motif; other site 650150002172 dimer interface [polypeptide binding]; other site 650150002173 KMSKS motif; other site 650150002174 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 650150002175 ArsC family; Region: ArsC; pfam03960 650150002176 putative catalytic residues [active] 650150002177 thiol/disulfide switch; other site 650150002178 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 650150002179 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 650150002180 Ligand Binding Site [chemical binding]; other site 650150002181 CAAX protease self-immunity; Region: Abi; pfam02517 650150002182 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 650150002183 AAA domain; Region: AAA_30; pfam13604 650150002184 Family description; Region: UvrD_C_2; pfam13538 650150002185 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 650150002186 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 650150002187 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 650150002188 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 650150002189 metal binding site [ion binding]; metal-binding site 650150002190 dimer interface [polypeptide binding]; other site 650150002191 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 650150002192 HPr interaction site; other site 650150002193 glycerol kinase (GK) interaction site [polypeptide binding]; other site 650150002194 active site 650150002195 phosphorylation site [posttranslational modification] 650150002196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150002198 non-specific DNA binding site [nucleotide binding]; other site 650150002199 sequence-specific DNA binding site [nucleotide binding]; other site 650150002200 salt bridge; other site 650150002201 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 650150002202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 650150002203 putative transposase OrfB; Reviewed; Region: PHA02517 650150002204 Integrase core domain; Region: rve; pfam00665 650150002205 Integrase core domain; Region: rve_3; pfam13683 650150002206 Transposase; Region: HTH_Tnp_1; pfam01527 650150002207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 650150002208 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150002209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150002210 Walker A/P-loop; other site 650150002211 ATP binding site [chemical binding]; other site 650150002212 Q-loop/lid; other site 650150002213 ABC transporter signature motif; other site 650150002214 Walker B; other site 650150002215 D-loop; other site 650150002216 H-loop/switch region; other site 650150002217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150002218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002219 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150002220 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 650150002221 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 650150002222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 650150002223 FeS/SAM binding site; other site 650150002224 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 650150002225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 650150002226 Transposase; Region: HTH_Tnp_1; pfam01527 650150002227 putative transposase OrfB; Reviewed; Region: PHA02517 650150002228 HTH-like domain; Region: HTH_21; pfam13276 650150002229 Integrase core domain; Region: rve; pfam00665 650150002230 Integrase core domain; Region: rve_2; pfam13333 650150002231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150002232 ABC transporter signature motif; other site 650150002233 Walker B; other site 650150002234 D-loop; other site 650150002235 H-loop/switch region; other site 650150002236 Integrase core domain; Region: rve; pfam00665 650150002237 HTH-like domain; Region: HTH_21; pfam13276 650150002238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 650150002239 FtsX-like permease family; Region: FtsX; pfam02687 650150002240 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 650150002241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150002242 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150002243 Walker A/P-loop; other site 650150002244 ATP binding site [chemical binding]; other site 650150002245 Q-loop/lid; other site 650150002246 ABC transporter signature motif; other site 650150002247 Walker B; other site 650150002248 D-loop; other site 650150002249 H-loop/switch region; other site 650150002250 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002251 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150002252 Walker A/P-loop; other site 650150002253 ATP binding site [chemical binding]; other site 650150002254 Q-loop/lid; other site 650150002255 ABC transporter signature motif; other site 650150002256 Walker B; other site 650150002257 D-loop; other site 650150002258 H-loop/switch region; other site 650150002259 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 650150002260 putative active site [active] 650150002261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002262 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150002263 Walker A/P-loop; other site 650150002264 ATP binding site [chemical binding]; other site 650150002265 Q-loop/lid; other site 650150002266 ABC transporter signature motif; other site 650150002267 Walker B; other site 650150002268 D-loop; other site 650150002269 H-loop/switch region; other site 650150002270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 650150002271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 650150002272 active site 650150002273 catalytic tetrad [active] 650150002274 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 650150002275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150002276 Coenzyme A binding pocket [chemical binding]; other site 650150002277 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 650150002278 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 650150002279 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 650150002280 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 650150002281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150002282 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 650150002283 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150002284 active site 650150002285 phosphorylation site [posttranslational modification] 650150002286 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 650150002287 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 650150002288 active site 650150002289 P-loop; other site 650150002290 phosphorylation site [posttranslational modification] 650150002291 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 650150002292 active site 650150002293 dimer interface [polypeptide binding]; other site 650150002294 magnesium binding site [ion binding]; other site 650150002295 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 650150002296 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 650150002297 AP (apurinic/apyrimidinic) site pocket; other site 650150002298 DNA interaction; other site 650150002299 Metal-binding active site; metal-binding site 650150002300 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 650150002301 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 650150002302 intersubunit interface [polypeptide binding]; other site 650150002303 active site 650150002304 Zn2+ binding site [ion binding]; other site 650150002305 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 650150002306 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 650150002307 Malic enzyme, N-terminal domain; Region: malic; pfam00390 650150002308 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 650150002309 putative NAD(P) binding site [chemical binding]; other site 650150002310 fumarate hydratase; Reviewed; Region: fumC; PRK00485 650150002311 Class II fumarases; Region: Fumarase_classII; cd01362 650150002312 active site 650150002313 tetramer interface [polypeptide binding]; other site 650150002314 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 650150002315 Aspartase; Region: Aspartase; cd01357 650150002316 active sites [active] 650150002317 tetramer interface [polypeptide binding]; other site 650150002318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150002319 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150002320 Walker A/P-loop; other site 650150002321 ATP binding site [chemical binding]; other site 650150002322 Q-loop/lid; other site 650150002323 ABC transporter signature motif; other site 650150002324 Walker B; other site 650150002325 D-loop; other site 650150002326 H-loop/switch region; other site 650150002327 DNA polymerase IV; Reviewed; Region: PRK03103 650150002328 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 650150002329 active site 650150002330 DNA binding site [nucleotide binding] 650150002331 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 650150002332 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 650150002333 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 650150002334 active site 650150002335 choline-binding protein, pseudogene, truncated by frameshift mutation 650150002336 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 650150002337 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 650150002338 FMN binding site [chemical binding]; other site 650150002339 active site 650150002340 catalytic residues [active] 650150002341 substrate binding site [chemical binding]; other site 650150002342 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 650150002343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150002344 ATP binding site [chemical binding]; other site 650150002345 putative Mg++ binding site [ion binding]; other site 650150002346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002347 nucleotide binding region [chemical binding]; other site 650150002348 ATP-binding site [chemical binding]; other site 650150002349 RQC domain; Region: RQC; pfam09382 650150002350 HRDC domain; Region: HRDC; pfam00570 650150002351 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 650150002352 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 650150002353 D-lactate dehydrogenase; Validated; Region: PRK08605 650150002354 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 650150002355 homodimer interface [polypeptide binding]; other site 650150002356 ligand binding site [chemical binding]; other site 650150002357 NAD binding site [chemical binding]; other site 650150002358 catalytic site [active] 650150002359 Transcriptional regulators [Transcription]; Region: GntR; COG1802 650150002360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150002361 DNA-binding site [nucleotide binding]; DNA binding site 650150002362 FCD domain; Region: FCD; pfam07729 650150002363 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 650150002364 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 650150002365 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 650150002366 Biotin operon repressor [Transcription]; Region: BirA; COG1654 650150002367 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 650150002368 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 650150002369 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 650150002370 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150002371 active site 650150002372 nucleotide binding site [chemical binding]; other site 650150002373 HIGH motif; other site 650150002374 KMSKS motif; other site 650150002375 citrate lyase subunit gamma; Provisional; Region: PRK13253 650150002376 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 650150002377 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 650150002378 Coenzyme A transferase; Region: CoA_trans; cl17247 650150002379 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 650150002380 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 650150002381 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 650150002382 active site 650150002383 catalytic residues [active] 650150002384 metal binding site [ion binding]; metal-binding site 650150002385 homodimer binding site [polypeptide binding]; other site 650150002386 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 650150002387 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 650150002388 carboxyltransferase (CT) interaction site; other site 650150002389 biotinylation site [posttranslational modification]; other site 650150002390 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 650150002391 Transposase; Region: HTH_Tnp_1; cl17663 650150002392 putative transposase OrfB; Reviewed; Region: PHA02517 650150002393 HTH-like domain; Region: HTH_21; pfam13276 650150002394 Integrase core domain; Region: rve; pfam00665 650150002395 Integrase core domain; Region: rve_3; pfam13683 650150002396 A new structural DNA glycosylase; Region: AlkD_like; cl11434 650150002397 active site 650150002398 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 650150002399 FOG: CBS domain [General function prediction only]; Region: COG0517 650150002400 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 650150002401 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 650150002402 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 650150002403 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 650150002404 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 650150002405 substrate binding site [chemical binding]; other site 650150002406 catalytic residues [active] 650150002407 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150002408 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 650150002409 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 650150002410 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 650150002411 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150002412 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150002413 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 650150002414 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150002415 Nuclease-related domain; Region: NERD; pfam08378 650150002416 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 650150002417 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 650150002418 LicD family; Region: LicD; pfam04991 650150002419 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 650150002420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150002421 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150002422 active site 650150002423 motif I; other site 650150002424 motif II; other site 650150002425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150002426 MepB protein; Region: MepB; cl01985 650150002427 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 650150002428 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 650150002429 Peptidase family C69; Region: Peptidase_C69; cl17793 650150002430 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 650150002431 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 650150002432 active site 650150002433 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 650150002434 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 650150002435 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 650150002436 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 650150002437 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002438 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002439 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 650150002440 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002441 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150002443 Coenzyme A binding pocket [chemical binding]; other site 650150002444 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 650150002445 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 650150002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150002447 putative substrate translocation pore; other site 650150002448 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 650150002449 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 650150002450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 650150002451 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 650150002452 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002453 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150002454 DNA binding residues [nucleotide binding] 650150002455 Integrase core domain; Region: rve; pfam00665 650150002456 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150002457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150002458 RNA binding surface [nucleotide binding]; other site 650150002459 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 650150002460 active site 650150002461 Protein of unknown function (DUF454); Region: DUF454; cl01063 650150002462 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 650150002463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150002464 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 650150002465 Walker A/P-loop; other site 650150002466 ATP binding site [chemical binding]; other site 650150002467 Q-loop/lid; other site 650150002468 ABC transporter signature motif; other site 650150002469 Walker B; other site 650150002470 D-loop; other site 650150002471 H-loop/switch region; other site 650150002472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150002473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150002474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150002475 Walker A/P-loop; other site 650150002476 ATP binding site [chemical binding]; other site 650150002477 Q-loop/lid; other site 650150002478 ABC transporter signature motif; other site 650150002479 Walker B; other site 650150002480 D-loop; other site 650150002481 H-loop/switch region; other site 650150002482 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 650150002483 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 650150002484 DNA binding site [nucleotide binding] 650150002485 active site 650150002486 arginine deiminase; Provisional; Region: PRK01388 650150002487 ornithine carbamoyltransferase; Validated; Region: PRK02102 650150002488 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 650150002489 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 650150002490 carbamate kinase; Reviewed; Region: PRK12686 650150002491 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 650150002492 putative substrate binding site [chemical binding]; other site 650150002493 nucleotide binding site [chemical binding]; other site 650150002494 nucleotide binding site [chemical binding]; other site 650150002495 homodimer interface [polypeptide binding]; other site 650150002496 Predicted membrane protein [Function unknown]; Region: COG1288 650150002497 Helix-turn-helix domain; Region: HTH_18; pfam12833 650150002498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150002499 Helix-turn-helix domain; Region: HTH_18; pfam12833 650150002500 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 650150002501 EDD domain protein, DegV family; Region: DegV; TIGR00762 650150002502 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 650150002503 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 650150002504 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 650150002505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002506 ATP binding site [chemical binding]; other site 650150002507 Mg2+ binding site [ion binding]; other site 650150002508 G-X-G motif; other site 650150002509 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150002511 active site 650150002512 phosphorylation site [posttranslational modification] 650150002513 intermolecular recognition site; other site 650150002514 dimerization interface [polypeptide binding]; other site 650150002515 LytTr DNA-binding domain; Region: LytTR; smart00850 650150002516 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 650150002517 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150002518 Walker A/P-loop; other site 650150002519 ATP binding site [chemical binding]; other site 650150002520 Q-loop/lid; other site 650150002521 ABC transporter signature motif; other site 650150002522 Walker B; other site 650150002523 D-loop; other site 650150002524 H-loop/switch region; other site 650150002525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150002526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150002527 non-specific DNA binding site [nucleotide binding]; other site 650150002528 salt bridge; other site 650150002529 sequence-specific DNA binding site [nucleotide binding]; other site 650150002530 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 650150002531 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 650150002532 Nitrogen regulatory protein P-II; Region: P-II; smart00938 650150002533 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150002534 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 650150002535 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 650150002536 hydrophobic ligand binding site; other site 650150002537 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150002538 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 650150002539 active site 650150002540 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 650150002541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150002542 DNA-binding site [nucleotide binding]; DNA binding site 650150002543 UTRA domain; Region: UTRA; cl17743 650150002544 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150002545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002547 ABC transporter; Region: ABC_tran_2; pfam12848 650150002548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002549 G5 domain; Region: G5; pfam07501 650150002550 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 650150002551 Cupin domain; Region: Cupin_2; cl17218 650150002552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150002553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150002554 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 650150002555 Flp/Fap pilin component; Region: Flp_Fap; cl01585 650150002556 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 650150002557 TadE-like protein; Region: TadE; pfam07811 650150002558 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 650150002559 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 650150002560 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 650150002561 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 650150002562 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 650150002563 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 650150002564 ATP binding site [chemical binding]; other site 650150002565 Walker A motif; other site 650150002566 hexamer interface [polypeptide binding]; other site 650150002567 Walker B motif; other site 650150002568 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 650150002569 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 650150002570 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 650150002571 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 650150002572 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 650150002573 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 650150002574 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 650150002575 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 650150002576 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 650150002577 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 650150002578 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 650150002579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150002580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150002581 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 650150002582 Predicted membrane protein [Function unknown]; Region: COG1511 650150002583 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 650150002584 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002585 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150002586 DNA binding residues [nucleotide binding] 650150002587 Integrase core domain; Region: rve; pfam00665 650150002588 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150002589 competence damage-inducible protein A; Provisional; Region: PRK00549 650150002590 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 650150002591 putative MPT binding site; other site 650150002592 Competence-damaged protein; Region: CinA; pfam02464 650150002593 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 650150002594 active site clefts [active] 650150002595 zinc binding site [ion binding]; other site 650150002596 dimer interface [polypeptide binding]; other site 650150002597 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 650150002598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002600 ABC transporter; Region: ABC_tran_2; pfam12848 650150002601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150002602 VanZ like family; Region: VanZ; pfam04892 650150002603 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150002604 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 650150002605 Uncharacterized conserved protein [Function unknown]; Region: COG3589 650150002606 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150002607 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150002608 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150002609 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 650150002610 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 650150002611 putative active site [active] 650150002612 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 650150002613 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 650150002614 putative active site [active] 650150002615 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 650150002616 Bacterial sugar transferase; Region: Bac_transf; pfam02397 650150002617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150002618 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 650150002619 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 650150002620 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 650150002621 NAD(P) binding site [chemical binding]; other site 650150002622 homodimer interface [polypeptide binding]; other site 650150002623 substrate binding site [chemical binding]; other site 650150002624 active site 650150002625 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 650150002626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150002627 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 650150002628 NAD(P) binding site [chemical binding]; other site 650150002629 active site 650150002630 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 650150002631 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 650150002632 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 650150002633 active site 650150002634 homodimer interface [polypeptide binding]; other site 650150002635 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 650150002636 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 650150002637 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 650150002638 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150002639 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 650150002640 active site 650150002641 Phosphotransferase enzyme family; Region: APH; pfam01636 650150002642 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150002643 active site 650150002644 ATP binding site [chemical binding]; other site 650150002645 substrate binding site [chemical binding]; other site 650150002646 dimer interface [polypeptide binding]; other site 650150002647 LicD family; Region: LicD; cl01378 650150002648 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 650150002649 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150002650 active site 650150002651 metal-binding site 650150002652 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150002653 Phosphotransferase enzyme family; Region: APH; pfam01636 650150002654 active site 650150002655 ATP binding site [chemical binding]; other site 650150002656 substrate binding site [chemical binding]; other site 650150002657 dimer interface [polypeptide binding]; other site 650150002658 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 650150002659 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 650150002660 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 650150002661 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 650150002662 CoenzymeA binding site [chemical binding]; other site 650150002663 subunit interaction site [polypeptide binding]; other site 650150002664 PHB binding site; other site 650150002665 Uncharacterized conserved protein [Function unknown]; Region: COG1416 650150002666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150002667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150002668 active site 650150002669 phosphorylation site [posttranslational modification] 650150002670 intermolecular recognition site; other site 650150002671 dimerization interface [polypeptide binding]; other site 650150002672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150002673 DNA binding site [nucleotide binding] 650150002674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150002675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 650150002676 dimerization interface [polypeptide binding]; other site 650150002677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150002678 dimer interface [polypeptide binding]; other site 650150002679 phosphorylation site [posttranslational modification] 650150002680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002681 ATP binding site [chemical binding]; other site 650150002682 Mg2+ binding site [ion binding]; other site 650150002683 G-X-G motif; other site 650150002684 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 650150002685 FtsX-like permease family; Region: FtsX; pfam02687 650150002686 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150002688 Walker A/P-loop; other site 650150002689 ATP binding site [chemical binding]; other site 650150002690 Q-loop/lid; other site 650150002691 ABC transporter signature motif; other site 650150002692 Walker B; other site 650150002693 D-loop; other site 650150002694 H-loop/switch region; other site 650150002695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 650150002696 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 650150002697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 650150002698 active site 650150002699 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 650150002700 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 650150002701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 650150002702 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 650150002703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150002704 Walker A/P-loop; other site 650150002705 ATP binding site [chemical binding]; other site 650150002706 Q-loop/lid; other site 650150002707 ABC transporter signature motif; other site 650150002708 Walker B; other site 650150002709 D-loop; other site 650150002710 H-loop/switch region; other site 650150002711 TOBE domain; Region: TOBE_2; pfam08402 650150002712 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150002713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150002714 dimer interface [polypeptide binding]; other site 650150002715 conserved gate region; other site 650150002716 putative PBP binding loops; other site 650150002717 ABC-ATPase subunit interface; other site 650150002718 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150002719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150002720 dimer interface [polypeptide binding]; other site 650150002721 conserved gate region; other site 650150002722 putative PBP binding loops; other site 650150002723 ABC-ATPase subunit interface; other site 650150002724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 650150002725 phosphopentomutase; Provisional; Region: PRK05362 650150002726 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 650150002727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 650150002728 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 650150002729 active site 650150002730 DNA binding site [nucleotide binding] 650150002731 Int/Topo IB signature motif; other site 650150002732 DNA polymerase IV; Validated; Region: PRK01810 650150002733 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 650150002734 active site 650150002735 DNA binding site [nucleotide binding] 650150002736 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 650150002737 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 650150002738 Walker A/P-loop; other site 650150002739 ATP binding site [chemical binding]; other site 650150002740 Q-loop/lid; other site 650150002741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 650150002742 ABC transporter signature motif; other site 650150002743 Walker B; other site 650150002744 D-loop; other site 650150002745 H-loop/switch region; other site 650150002746 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 650150002747 TPP-binding site [chemical binding]; other site 650150002748 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 650150002749 PYR/PP interface [polypeptide binding]; other site 650150002750 dimer interface [polypeptide binding]; other site 650150002751 TPP binding site [chemical binding]; other site 650150002752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 650150002753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 650150002754 substrate binding pocket [chemical binding]; other site 650150002755 chain length determination region; other site 650150002756 substrate-Mg2+ binding site; other site 650150002757 catalytic residues [active] 650150002758 aspartate-rich region 1; other site 650150002759 active site lid residues [active] 650150002760 aspartate-rich region 2; other site 650150002761 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 650150002762 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 650150002763 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 650150002764 generic binding surface II; other site 650150002765 generic binding surface I; other site 650150002766 transcription antitermination factor NusB; Region: nusB; TIGR01951 650150002767 Asp23 family; Region: Asp23; pfam03780 650150002768 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 650150002769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150002770 S-adenosylmethionine binding site [chemical binding]; other site 650150002771 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 650150002772 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 650150002773 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 650150002774 active site 650150002775 Riboflavin kinase; Region: Flavokinase; pfam01687 650150002776 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 650150002777 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 650150002778 RNA binding site [nucleotide binding]; other site 650150002779 active site 650150002780 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 650150002781 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 650150002782 substrate binding pocket [chemical binding]; other site 650150002783 membrane-bound complex binding site; other site 650150002784 hinge residues; other site 650150002785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150002786 dimer interface [polypeptide binding]; other site 650150002787 conserved gate region; other site 650150002788 putative PBP binding loops; other site 650150002789 ABC-ATPase subunit interface; other site 650150002790 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 650150002791 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 650150002792 Walker A/P-loop; other site 650150002793 ATP binding site [chemical binding]; other site 650150002794 Q-loop/lid; other site 650150002795 ABC transporter signature motif; other site 650150002796 Walker B; other site 650150002797 D-loop; other site 650150002798 H-loop/switch region; other site 650150002799 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002800 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150002801 DNA binding residues [nucleotide binding] 650150002802 Integrase core domain; Region: rve; pfam00665 650150002803 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 650150002804 translation initiation factor IF-2; Region: IF-2; TIGR00487 650150002805 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 650150002806 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 650150002807 G1 box; other site 650150002808 putative GEF interaction site [polypeptide binding]; other site 650150002809 GTP/Mg2+ binding site [chemical binding]; other site 650150002810 Switch I region; other site 650150002811 G2 box; other site 650150002812 G3 box; other site 650150002813 Switch II region; other site 650150002814 G4 box; other site 650150002815 G5 box; other site 650150002816 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 650150002817 Translation-initiation factor 2; Region: IF-2; pfam11987 650150002818 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 650150002819 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 650150002820 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 650150002821 putative RNA binding cleft [nucleotide binding]; other site 650150002822 NusA N-terminal domain; Region: NusA_N; pfam08529 650150002823 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 650150002824 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 650150002825 RNA binding site [nucleotide binding]; other site 650150002826 homodimer interface [polypeptide binding]; other site 650150002827 NusA-like KH domain; Region: KH_5; pfam13184 650150002828 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 650150002829 G-X-X-G motif; other site 650150002830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 650150002831 Sm and related proteins; Region: Sm_like; cl00259 650150002832 heptamer interface [polypeptide binding]; other site 650150002833 Sm1 motif; other site 650150002834 hexamer interface [polypeptide binding]; other site 650150002835 RNA binding site [nucleotide binding]; other site 650150002836 Sm2 motif; other site 650150002837 DNA polymerase III PolC; Validated; Region: polC; PRK00448 650150002838 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 650150002839 generic binding surface II; other site 650150002840 generic binding surface I; other site 650150002841 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 650150002842 active site 650150002843 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 650150002844 active site 650150002845 catalytic site [active] 650150002846 substrate binding site [chemical binding]; other site 650150002847 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 650150002848 ribonuclease III; Reviewed; Region: rnc; PRK00102 650150002849 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 650150002850 dimerization interface [polypeptide binding]; other site 650150002851 active site 650150002852 metal binding site [ion binding]; metal-binding site 650150002853 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 650150002854 dsRNA binding site [nucleotide binding]; other site 650150002855 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 650150002856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150002857 ATP binding site [chemical binding]; other site 650150002858 putative Mg++ binding site [ion binding]; other site 650150002859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002860 nucleotide binding region [chemical binding]; other site 650150002861 ATP-binding site [chemical binding]; other site 650150002862 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 650150002863 DAK2 domain; Region: Dak2; pfam02734 650150002864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 650150002865 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 650150002866 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 650150002867 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 650150002868 active site 650150002869 homodimer interface [polypeptide binding]; other site 650150002870 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 650150002871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150002872 Walker A motif; other site 650150002873 ATP binding site [chemical binding]; other site 650150002874 Walker B motif; other site 650150002875 arginine finger; other site 650150002876 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 650150002877 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 650150002878 RuvA N terminal domain; Region: RuvA_N; pfam01330 650150002879 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 650150002880 GTPase CgtA; Reviewed; Region: obgE; PRK12297 650150002881 GTP1/OBG; Region: GTP1_OBG; pfam01018 650150002882 Obg GTPase; Region: Obg; cd01898 650150002883 G1 box; other site 650150002884 GTP/Mg2+ binding site [chemical binding]; other site 650150002885 Switch I region; other site 650150002886 G2 box; other site 650150002887 G3 box; other site 650150002888 Switch II region; other site 650150002889 G4 box; other site 650150002890 G5 box; other site 650150002891 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 650150002892 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 650150002893 Protein of unknown function (DUF464); Region: DUF464; pfam04327 650150002894 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 650150002895 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 650150002896 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 650150002897 NodB motif; other site 650150002898 active site 650150002899 catalytic site [active] 650150002900 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002901 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150002902 DNA binding residues [nucleotide binding] 650150002903 Integrase core domain; Region: rve; pfam00665 650150002904 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 650150002905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 650150002906 dimerization interface [polypeptide binding]; other site 650150002907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150002908 dimer interface [polypeptide binding]; other site 650150002909 phosphorylation site [posttranslational modification] 650150002910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002911 ATP binding site [chemical binding]; other site 650150002912 Mg2+ binding site [ion binding]; other site 650150002913 G-X-G motif; other site 650150002914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150002915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150002916 active site 650150002917 phosphorylation site [posttranslational modification] 650150002918 intermolecular recognition site; other site 650150002919 dimerization interface [polypeptide binding]; other site 650150002920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150002921 DNA binding site [nucleotide binding] 650150002922 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 650150002923 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 650150002924 active site 650150002925 PHP Thumb interface [polypeptide binding]; other site 650150002926 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 650150002927 generic binding surface II; other site 650150002928 generic binding surface I; other site 650150002929 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 650150002930 DHH family; Region: DHH; pfam01368 650150002931 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 650150002932 propionate/acetate kinase; Provisional; Region: PRK12379 650150002933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 650150002934 DNA binding residues [nucleotide binding] 650150002935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 650150002936 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 650150002937 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 650150002938 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 650150002939 P loop; other site 650150002940 GTP binding site [chemical binding]; other site 650150002941 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 650150002942 AAA domain; Region: AAA_23; pfam13476 650150002943 Walker A/P-loop; other site 650150002944 ATP binding site [chemical binding]; other site 650150002945 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 650150002946 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 650150002947 ABC transporter signature motif; other site 650150002948 Walker B; other site 650150002949 D-loop; other site 650150002950 H-loop/switch region; other site 650150002951 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 650150002952 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 650150002953 Methyltransferase domain; Region: Methyltransf_25; pfam13649 650150002954 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 650150002955 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 650150002956 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 650150002957 active site 650150002958 (T/H)XGH motif; other site 650150002959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150002960 Zn2+ binding site [ion binding]; other site 650150002961 Mg2+ binding site [ion binding]; other site 650150002962 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 650150002963 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 650150002964 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 650150002965 GTP/Mg2+ binding site [chemical binding]; other site 650150002966 G4 box; other site 650150002967 G5 box; other site 650150002968 G1 box; other site 650150002969 Switch I region; other site 650150002970 G2 box; other site 650150002971 G3 box; other site 650150002972 Switch II region; other site 650150002973 adenylosuccinate lyase; Provisional; Region: PRK07492 650150002974 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 650150002975 tetramer interface [polypeptide binding]; other site 650150002976 active site 650150002977 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 650150002978 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 650150002979 CAP-like domain; other site 650150002980 active site 650150002981 primary dimer interface [polypeptide binding]; other site 650150002982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150002983 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 650150002984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002985 ATP binding site [chemical binding]; other site 650150002986 Mg2+ binding site [ion binding]; other site 650150002987 G-X-G motif; other site 650150002988 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 650150002989 anchoring element; other site 650150002990 dimer interface [polypeptide binding]; other site 650150002991 ATP binding site [chemical binding]; other site 650150002992 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 650150002993 active site 650150002994 putative metal-binding site [ion binding]; other site 650150002995 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 650150002996 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 650150002997 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 650150002998 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150002999 Walker A/P-loop; other site 650150003000 ATP binding site [chemical binding]; other site 650150003001 Q-loop/lid; other site 650150003002 ABC transporter signature motif; other site 650150003003 Walker B; other site 650150003004 D-loop; other site 650150003005 H-loop/switch region; other site 650150003006 hypothetical protein; Provisional; Region: PRK12378 650150003007 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 650150003008 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 650150003009 putative tRNA-binding site [nucleotide binding]; other site 650150003010 B3/4 domain; Region: B3_4; pfam03483 650150003011 tRNA synthetase B5 domain; Region: B5; smart00874 650150003012 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 650150003013 dimer interface [polypeptide binding]; other site 650150003014 motif 1; other site 650150003015 motif 3; other site 650150003016 motif 2; other site 650150003017 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 650150003018 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 650150003019 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 650150003020 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 650150003021 dimer interface [polypeptide binding]; other site 650150003022 motif 1; other site 650150003023 active site 650150003024 motif 2; other site 650150003025 motif 3; other site 650150003026 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 650150003027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 650150003028 ABC-ATPase subunit interface; other site 650150003029 dimer interface [polypeptide binding]; other site 650150003030 putative PBP binding regions; other site 650150003031 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150003032 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 650150003033 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 650150003034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 650150003035 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150003036 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 650150003037 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 650150003038 IHF dimer interface [polypeptide binding]; other site 650150003039 IHF - DNA interface [nucleotide binding]; other site 650150003040 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 650150003041 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 650150003042 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 650150003043 GTP-binding protein Der; Reviewed; Region: PRK00093 650150003044 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 650150003045 G1 box; other site 650150003046 GTP/Mg2+ binding site [chemical binding]; other site 650150003047 Switch I region; other site 650150003048 G2 box; other site 650150003049 Switch II region; other site 650150003050 G3 box; other site 650150003051 G4 box; other site 650150003052 G5 box; other site 650150003053 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 650150003054 G1 box; other site 650150003055 GTP/Mg2+ binding site [chemical binding]; other site 650150003056 Switch I region; other site 650150003057 G2 box; other site 650150003058 G3 box; other site 650150003059 Switch II region; other site 650150003060 G4 box; other site 650150003061 G5 box; other site 650150003062 cytidylate kinase; Provisional; Region: cmk; PRK00023 650150003063 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 650150003064 CMP-binding site; other site 650150003065 The sites determining sugar specificity; other site 650150003066 Predicted membrane protein [Function unknown]; Region: COG3601 650150003067 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 650150003068 elongation factor P; Validated; Region: PRK00529 650150003069 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 650150003070 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 650150003071 RNA binding site [nucleotide binding]; other site 650150003072 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 650150003073 RNA binding site [nucleotide binding]; other site 650150003074 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 650150003075 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 650150003076 Type II/IV secretion system protein; Region: T2SE; pfam00437 650150003077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 650150003078 Walker A motif; other site 650150003079 ATP binding site [chemical binding]; other site 650150003080 Walker B motif; other site 650150003081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 650150003082 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 650150003083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 650150003084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150003085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150003086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 650150003087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 650150003088 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 650150003089 ATP binding site [chemical binding]; other site 650150003090 putative Mg++ binding site [ion binding]; other site 650150003091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003092 nucleotide binding region [chemical binding]; other site 650150003093 ATP-binding site [chemical binding]; other site 650150003094 Family of unknown function (DUF633); Region: DUF633; pfam04816 650150003095 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 650150003096 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 650150003097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 650150003098 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 650150003099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 650150003100 DNA binding residues [nucleotide binding] 650150003101 DNA primase; Validated; Region: dnaG; PRK05667 650150003102 CHC2 zinc finger; Region: zf-CHC2; pfam01807 650150003103 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 650150003104 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 650150003105 active site 650150003106 metal binding site [ion binding]; metal-binding site 650150003107 interdomain interaction site; other site 650150003108 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 650150003109 glycyl-tRNA synthetase; Provisional; Region: PRK04173 650150003110 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150003111 motif 1; other site 650150003112 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 650150003113 active site 650150003114 motif 2; other site 650150003115 motif 3; other site 650150003116 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 650150003117 anticodon binding site; other site 650150003118 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 650150003119 Recombination protein O N terminal; Region: RecO_N; pfam11967 650150003120 Recombination protein O C terminal; Region: RecO_C; pfam02565 650150003121 GTPase Era; Reviewed; Region: era; PRK00089 650150003122 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 650150003123 G1 box; other site 650150003124 GTP/Mg2+ binding site [chemical binding]; other site 650150003125 Switch I region; other site 650150003126 G2 box; other site 650150003127 Switch II region; other site 650150003128 G3 box; other site 650150003129 G4 box; other site 650150003130 G5 box; other site 650150003131 KH domain; Region: KH_2; pfam07650 650150003132 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 650150003133 active site 650150003134 catalytic motif [active] 650150003135 Zn binding site [ion binding]; other site 650150003136 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 650150003137 metal-binding heat shock protein; Provisional; Region: PRK00016 650150003138 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 650150003139 PhoU domain; Region: PhoU; pfam01895 650150003140 PhoU domain; Region: PhoU; pfam01895 650150003141 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 650150003142 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 650150003143 Walker A/P-loop; other site 650150003144 ATP binding site [chemical binding]; other site 650150003145 Q-loop/lid; other site 650150003146 ABC transporter signature motif; other site 650150003147 Walker B; other site 650150003148 D-loop; other site 650150003149 H-loop/switch region; other site 650150003150 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 650150003151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150003152 dimer interface [polypeptide binding]; other site 650150003153 conserved gate region; other site 650150003154 putative PBP binding loops; other site 650150003155 ABC-ATPase subunit interface; other site 650150003156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150003157 dimer interface [polypeptide binding]; other site 650150003158 conserved gate region; other site 650150003159 putative PBP binding loops; other site 650150003160 ABC-ATPase subunit interface; other site 650150003161 PBP superfamily domain; Region: PBP_like_2; cl17296 650150003162 PBP superfamily domain; Region: PBP_like_2; cl17296 650150003163 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 650150003164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 650150003165 dimer interface [polypeptide binding]; other site 650150003166 phosphorylation site [posttranslational modification] 650150003167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150003168 ATP binding site [chemical binding]; other site 650150003169 Mg2+ binding site [ion binding]; other site 650150003170 G-X-G motif; other site 650150003171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150003172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150003173 active site 650150003174 phosphorylation site [posttranslational modification] 650150003175 intermolecular recognition site; other site 650150003176 dimerization interface [polypeptide binding]; other site 650150003177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150003178 DNA binding site [nucleotide binding] 650150003179 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 650150003180 PhoH-like protein; Region: PhoH; pfam02562 650150003181 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 650150003182 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 650150003183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 650150003184 ATP binding site [chemical binding]; other site 650150003185 Mg++ binding site [ion binding]; other site 650150003186 motif III; other site 650150003187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003188 nucleotide binding region [chemical binding]; other site 650150003189 ATP-binding site [chemical binding]; other site 650150003190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003191 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 650150003192 Walker A/P-loop; other site 650150003193 ATP binding site [chemical binding]; other site 650150003194 Q-loop/lid; other site 650150003195 ABC transporter signature motif; other site 650150003196 Walker B; other site 650150003197 D-loop; other site 650150003198 H-loop/switch region; other site 650150003199 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 650150003200 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 650150003201 intersubunit interface [polypeptide binding]; other site 650150003202 active site 650150003203 catalytic residue [active] 650150003204 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 650150003205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150003206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150003207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150003208 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 650150003209 RNA methyltransferase, RsmE family; Region: TIGR00046 650150003210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150003211 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150003212 RNA binding surface [nucleotide binding]; other site 650150003213 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 650150003214 active site 650150003215 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 650150003216 ScpA/B protein; Region: ScpA_ScpB; cl00598 650150003217 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 650150003218 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 650150003219 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 650150003220 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 650150003221 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 650150003222 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 650150003223 folate binding site [chemical binding]; other site 650150003224 NADP+ binding site [chemical binding]; other site 650150003225 thymidylate synthase; Region: thym_sym; TIGR03284 650150003226 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 650150003227 dimerization interface [polypeptide binding]; other site 650150003228 active site 650150003229 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 650150003230 generic binding surface II; other site 650150003231 generic binding surface I; other site 650150003232 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 650150003233 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 650150003234 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 650150003235 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 650150003236 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 650150003237 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 650150003238 active site 650150003239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150003240 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150003241 TM-ABC transporter signature motif; other site 650150003242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150003243 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150003244 TM-ABC transporter signature motif; other site 650150003245 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 650150003246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 650150003247 Walker A/P-loop; other site 650150003248 ATP binding site [chemical binding]; other site 650150003249 Q-loop/lid; other site 650150003250 ABC transporter signature motif; other site 650150003251 Walker B; other site 650150003252 D-loop; other site 650150003253 H-loop/switch region; other site 650150003254 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 650150003255 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150003256 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150003257 ligand binding site [chemical binding]; other site 650150003258 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150003259 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150003260 ligand binding site [chemical binding]; other site 650150003261 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 650150003262 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 650150003263 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 650150003264 active site 650150003265 dimer interface [polypeptide binding]; other site 650150003266 motif 1; other site 650150003267 motif 2; other site 650150003268 motif 3; other site 650150003269 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 650150003270 anticodon binding site; other site 650150003271 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 650150003272 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 650150003273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150003274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150003275 nucleotide binding site [chemical binding]; other site 650150003276 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 650150003277 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 650150003278 domain interfaces; other site 650150003279 active site 650150003280 6-phosphofructokinase; Provisional; Region: PRK03202 650150003281 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 650150003282 active site 650150003283 ADP/pyrophosphate binding site [chemical binding]; other site 650150003284 dimerization interface [polypeptide binding]; other site 650150003285 allosteric effector site; other site 650150003286 fructose-1,6-bisphosphate binding site; other site 650150003287 primosomal protein DnaI; Reviewed; Region: PRK08939 650150003288 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 650150003289 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 650150003290 dephospho-CoA kinase; Region: TIGR00152 650150003291 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 650150003292 CoA-binding site [chemical binding]; other site 650150003293 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 650150003294 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 650150003295 DNA binding site [nucleotide binding] 650150003296 catalytic residue [active] 650150003297 H2TH interface [polypeptide binding]; other site 650150003298 putative catalytic residues [active] 650150003299 turnover-facilitating residue; other site 650150003300 intercalation triad [nucleotide binding]; other site 650150003301 8OG recognition residue [nucleotide binding]; other site 650150003302 putative reading head residues; other site 650150003303 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 650150003304 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 650150003305 DNA polymerase I; Provisional; Region: PRK05755 650150003306 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 650150003307 active site 650150003308 metal binding site 1 [ion binding]; metal-binding site 650150003309 putative 5' ssDNA interaction site; other site 650150003310 metal binding site 3; metal-binding site 650150003311 metal binding site 2 [ion binding]; metal-binding site 650150003312 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 650150003313 putative DNA binding site [nucleotide binding]; other site 650150003314 putative metal binding site [ion binding]; other site 650150003315 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 650150003316 active site 650150003317 substrate binding site [chemical binding]; other site 650150003318 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 650150003319 active site 650150003320 DNA binding site [nucleotide binding] 650150003321 catalytic site [active] 650150003322 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 650150003323 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 650150003324 intersubunit interface [polypeptide binding]; other site 650150003325 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 650150003326 Domain of unknown function DUF20; Region: UPF0118; pfam01594 650150003327 rod shape-determining protein MreC; Provisional; Region: PRK13922 650150003328 rod shape-determining protein MreC; Region: MreC; pfam04085 650150003329 hypothetical protein; Reviewed; Region: PRK00024 650150003330 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 650150003331 MPN+ (JAMM) motif; other site 650150003332 Zinc-binding site [ion binding]; other site 650150003333 cell division protein FtsZ; Validated; Region: PRK09330 650150003334 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 650150003335 nucleotide binding site [chemical binding]; other site 650150003336 SulA interaction site; other site 650150003337 cell division protein FtsA; Region: ftsA; TIGR01174 650150003338 Cell division protein FtsA; Region: FtsA; smart00842 650150003339 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 650150003340 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 650150003341 Thiamine pyrophosphokinase; Region: TPK; cd07995 650150003342 active site 650150003343 dimerization interface [polypeptide binding]; other site 650150003344 thiamine binding site [chemical binding]; other site 650150003345 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 650150003346 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 650150003347 substrate binding site [chemical binding]; other site 650150003348 hexamer interface [polypeptide binding]; other site 650150003349 metal binding site [ion binding]; metal-binding site 650150003350 GTPase RsgA; Reviewed; Region: PRK00098 650150003351 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 650150003352 RNA binding site [nucleotide binding]; other site 650150003353 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 650150003354 GTPase/Zn-binding domain interface [polypeptide binding]; other site 650150003355 GTP/Mg2+ binding site [chemical binding]; other site 650150003356 G4 box; other site 650150003357 G5 box; other site 650150003358 G1 box; other site 650150003359 Switch I region; other site 650150003360 G2 box; other site 650150003361 G3 box; other site 650150003362 Switch II region; other site 650150003363 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 650150003364 Catalytic domain of Protein Kinases; Region: PKc; cd00180 650150003365 active site 650150003366 ATP binding site [chemical binding]; other site 650150003367 substrate binding site [chemical binding]; other site 650150003368 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 650150003369 substrate binding site [chemical binding]; other site 650150003370 activation loop (A-loop); other site 650150003371 activation loop (A-loop); other site 650150003372 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150003373 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150003374 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150003375 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 650150003376 active site 650150003377 NusB family; Region: NusB; pfam01029 650150003378 16S rRNA methyltransferase B; Provisional; Region: PRK14902 650150003379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150003380 S-adenosylmethionine binding site [chemical binding]; other site 650150003381 primosome assembly protein PriA; Validated; Region: PRK05580 650150003382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150003383 ATP binding site [chemical binding]; other site 650150003384 putative Mg++ binding site [ion binding]; other site 650150003385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003386 nucleotide binding region [chemical binding]; other site 650150003387 ATP-binding site [chemical binding]; other site 650150003388 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 650150003389 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 650150003390 catalytic site [active] 650150003391 G-X2-G-X-G-K; other site 650150003392 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 650150003393 Domain of unknown function (DUF814); Region: DUF814; pfam05670 650150003394 Protein of unknown function DUF45; Region: DUF45; pfam01863 650150003395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150003396 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150003397 active site 650150003398 motif I; other site 650150003399 motif II; other site 650150003400 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 650150003401 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150003402 Zn2+ binding site [ion binding]; other site 650150003403 Mg2+ binding site [ion binding]; other site 650150003404 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 650150003405 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 650150003406 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 650150003407 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 650150003408 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 650150003409 V-type ATP synthase subunit B; Provisional; Region: PRK04196 650150003410 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150003411 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 650150003412 Walker A motif homologous position; other site 650150003413 Walker B motif; other site 650150003414 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150003415 V-type ATP synthase subunit A; Provisional; Region: PRK04192 650150003416 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150003417 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 650150003418 Walker A motif/ATP binding site; other site 650150003419 Walker B motif; other site 650150003420 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150003421 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 650150003422 ATP synthase subunit C; Region: ATP-synt_C; cl00466 650150003423 V-type ATP synthase subunit I; Validated; Region: PRK05771 650150003424 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 650150003425 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 650150003426 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 650150003427 active site 650150003428 ADP/pyrophosphate binding site [chemical binding]; other site 650150003429 allosteric effector site; other site 650150003430 dimerization interface [polypeptide binding]; other site 650150003431 fructose-1,6-bisphosphate binding site; other site 650150003432 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003435 ABC transporter; Region: ABC_tran_2; pfam12848 650150003436 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003437 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 650150003438 active site 650150003439 metal binding site [ion binding]; metal-binding site 650150003440 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 650150003441 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 650150003442 putative dimer interface [polypeptide binding]; other site 650150003443 putative anticodon binding site; other site 650150003444 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 650150003445 homodimer interface [polypeptide binding]; other site 650150003446 motif 1; other site 650150003447 motif 2; other site 650150003448 active site 650150003449 motif 3; other site 650150003450 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 650150003451 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 650150003452 CoA binding domain; Region: CoA_binding; pfam02629 650150003453 UGMP family protein; Validated; Region: PRK09604 650150003454 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 650150003455 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 650150003456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150003457 Coenzyme A binding pocket [chemical binding]; other site 650150003458 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 650150003459 Glycoprotease family; Region: Peptidase_M22; pfam00814 650150003460 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 650150003461 Protein of unknown function (DUF402); Region: DUF402; cl00979 650150003462 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 650150003463 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 650150003464 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 650150003465 tetramer interfaces [polypeptide binding]; other site 650150003466 binuclear metal-binding site [ion binding]; other site 650150003467 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 650150003468 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 650150003469 active site 650150003470 Zn binding site [ion binding]; other site 650150003471 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 650150003472 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 650150003473 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 650150003474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150003475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150003476 Coenzyme A binding pocket [chemical binding]; other site 650150003477 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 650150003478 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 650150003479 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 650150003480 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 650150003481 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150003482 active site 650150003483 HIGH motif; other site 650150003484 nucleotide binding site [chemical binding]; other site 650150003485 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 650150003486 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 650150003487 active site 650150003488 KMSKS motif; other site 650150003489 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 650150003490 tRNA binding surface [nucleotide binding]; other site 650150003491 anticodon binding site; other site 650150003492 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 650150003493 DivIVA protein; Region: DivIVA; pfam05103 650150003494 Protein of unknown function (DUF552); Region: DUF552; pfam04472 650150003495 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 650150003496 30S subunit binding site; other site 650150003497 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 650150003498 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 650150003499 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 650150003500 hexamer interface [polypeptide binding]; other site 650150003501 ligand binding site [chemical binding]; other site 650150003502 putative active site [active] 650150003503 NAD(P) binding site [chemical binding]; other site 650150003504 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 650150003505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150003506 motif II; other site 650150003507 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 650150003508 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 650150003509 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003510 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 650150003511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150003512 motif II; other site 650150003513 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150003514 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150003515 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150003516 DNA binding residues [nucleotide binding] 650150003517 Integrase core domain; Region: rve; pfam00665 650150003518 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 650150003519 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 650150003520 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 650150003521 Walker A/P-loop; other site 650150003522 ATP binding site [chemical binding]; other site 650150003523 Q-loop/lid; other site 650150003524 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 650150003525 Q-loop/lid; other site 650150003526 ABC transporter signature motif; other site 650150003527 Walker B; other site 650150003528 D-loop; other site 650150003529 H-loop/switch region; other site 650150003530 exonuclease subunit SbcD; Provisional; Region: PRK10966 650150003531 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 650150003532 active site 650150003533 metal binding site [ion binding]; metal-binding site 650150003534 DNA binding site [nucleotide binding] 650150003535 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 650150003536 Excalibur calcium-binding domain; Region: Excalibur; smart00894 650150003537 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 650150003538 active site 650150003539 catalytic residues [active] 650150003540 galactokinase; Provisional; Region: PRK05322 650150003541 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 650150003542 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 650150003543 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150003544 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150003545 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 650150003546 TM-ABC transporter signature motif; other site 650150003547 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 650150003548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 650150003549 Walker A/P-loop; other site 650150003550 ATP binding site [chemical binding]; other site 650150003551 Q-loop/lid; other site 650150003552 ABC transporter signature motif; other site 650150003553 Walker B; other site 650150003554 D-loop; other site 650150003555 H-loop/switch region; other site 650150003556 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 650150003557 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 650150003558 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 650150003559 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150003560 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150003561 DNA binding site [nucleotide binding] 650150003562 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 650150003563 putative ligand binding site [chemical binding]; other site 650150003564 putative dimerization interface [polypeptide binding]; other site 650150003565 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 650150003566 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 650150003567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150003568 active site 650150003569 HIGH motif; other site 650150003570 nucleotide binding site [chemical binding]; other site 650150003571 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 650150003572 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 650150003573 active site 650150003574 KMSKS motif; other site 650150003575 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 650150003576 tRNA binding surface [nucleotide binding]; other site 650150003577 anticodon binding site; other site 650150003578 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 650150003579 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150003580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150003581 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 650150003582 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 650150003583 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 650150003584 G1 box; other site 650150003585 GTP/Mg2+ binding site [chemical binding]; other site 650150003586 Switch I region; other site 650150003587 G2 box; other site 650150003588 G3 box; other site 650150003589 Switch II region; other site 650150003590 G4 box; other site 650150003591 G5 box; other site 650150003592 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 650150003593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150003594 Walker A motif; other site 650150003595 ATP binding site [chemical binding]; other site 650150003596 Walker B motif; other site 650150003597 arginine finger; other site 650150003598 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 650150003599 trigger factor; Provisional; Region: tig; PRK01490 650150003600 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 650150003601 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 650150003602 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 650150003603 G5 domain; Region: G5; pfam07501 650150003604 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 650150003605 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 650150003606 active site 650150003607 metal binding site [ion binding]; metal-binding site 650150003608 homotetramer interface [polypeptide binding]; other site 650150003609 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 650150003610 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 650150003611 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 650150003612 GIY-YIG motif/motif A; other site 650150003613 active site 650150003614 catalytic site [active] 650150003615 putative DNA binding site [nucleotide binding]; other site 650150003616 metal binding site [ion binding]; metal-binding site 650150003617 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 650150003618 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 650150003619 MutS domain III; Region: MutS_III; pfam05192 650150003620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150003621 Walker A/P-loop; other site 650150003622 ATP binding site [chemical binding]; other site 650150003623 Q-loop/lid; other site 650150003624 ABC transporter signature motif; other site 650150003625 Walker B; other site 650150003626 D-loop; other site 650150003627 H-loop/switch region; other site 650150003628 Smr domain; Region: Smr; pfam01713 650150003629 Colicin V production protein; Region: Colicin_V; pfam02674 650150003630 ribonuclease HIII; Provisional; Region: PRK00996 650150003631 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 650150003632 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 650150003633 RNA/DNA hybrid binding site [nucleotide binding]; other site 650150003634 active site 650150003635 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 650150003636 catalytic motif [active] 650150003637 Zn binding site [ion binding]; other site 650150003638 Rhomboid family; Region: Rhomboid; pfam01694 650150003639 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150003640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150003641 RNA binding surface [nucleotide binding]; other site 650150003642 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 650150003643 active site 650150003644 lipoprotein signal peptidase; Provisional; Region: PRK14787 650150003645 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 650150003646 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 650150003647 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 650150003648 Isochorismatase family; Region: Isochorismatase; pfam00857 650150003649 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 650150003650 catalytic triad [active] 650150003651 conserved cis-peptide bond; other site 650150003652 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 650150003653 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 650150003654 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150003655 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150003656 Walker A/P-loop; other site 650150003657 ATP binding site [chemical binding]; other site 650150003658 Q-loop/lid; other site 650150003659 ABC transporter signature motif; other site 650150003660 Walker B; other site 650150003661 D-loop; other site 650150003662 H-loop/switch region; other site 650150003663 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 650150003664 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003667 integral membrane protein MviN; Region: mviN; TIGR01695 650150003668 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 650150003669 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 650150003670 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 650150003671 active site 650150003672 (T/H)XGH motif; other site 650150003673 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 650150003674 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 650150003675 active site 650150003676 P-loop; other site 650150003677 phosphorylation site [posttranslational modification] 650150003678 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 650150003679 Domain of unknown function DUF87; Region: DUF87; pfam01935 650150003680 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 650150003681 methionine cluster; other site 650150003682 active site 650150003683 phosphorylation site [posttranslational modification] 650150003684 metal binding site [ion binding]; metal-binding site 650150003685 Tubby C 2; Region: Tub_2; cl02043 650150003686 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 650150003687 trimer interface [polypeptide binding]; other site 650150003688 putative Zn binding site [ion binding]; other site 650150003689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003690 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 650150003692 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 650150003693 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150003694 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003695 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003696 PhoU domain; Region: PhoU; pfam01895 650150003697 PhoU domain; Region: PhoU; pfam01895 650150003698 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150003699 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003700 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003701 PhoU domain; Region: PhoU; pfam01895 650150003702 PhoU domain; Region: PhoU; pfam01895 650150003703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 650150003704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150003705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150003706 Coenzyme A binding pocket [chemical binding]; other site 650150003707 Ferritin-like domain; Region: Ferritin; pfam00210 650150003708 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 650150003709 dimerization interface [polypeptide binding]; other site 650150003710 DPS ferroxidase diiron center [ion binding]; other site 650150003711 ion pore; other site 650150003712 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 650150003713 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 650150003714 23S rRNA interface [nucleotide binding]; other site 650150003715 L3 interface [polypeptide binding]; other site 650150003716 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 650150003717 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 650150003718 dimerization interface 3.5A [polypeptide binding]; other site 650150003719 active site 650150003720 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 650150003721 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 650150003722 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 650150003723 Walker A/P-loop; other site 650150003724 ATP binding site [chemical binding]; other site 650150003725 Q-loop/lid; other site 650150003726 ABC transporter signature motif; other site 650150003727 Walker B; other site 650150003728 D-loop; other site 650150003729 H-loop/switch region; other site 650150003730 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 650150003731 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 650150003732 Walker A/P-loop; other site 650150003733 ATP binding site [chemical binding]; other site 650150003734 Q-loop/lid; other site 650150003735 ABC transporter signature motif; other site 650150003736 Walker B; other site 650150003737 D-loop; other site 650150003738 H-loop/switch region; other site 650150003739 peptidase T; Region: peptidase-T; TIGR01882 650150003740 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 650150003741 metal binding site [ion binding]; metal-binding site 650150003742 dimer interface [polypeptide binding]; other site 650150003743 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 650150003744 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 650150003745 active site 650150003746 metal binding site [ion binding]; metal-binding site 650150003747 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 650150003748 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150003749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150003750 non-specific DNA binding site [nucleotide binding]; other site 650150003751 salt bridge; other site 650150003752 sequence-specific DNA binding site [nucleotide binding]; other site 650150003753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150003754 nucleotide binding site [chemical binding]; other site 650150003755 Uncharacterized conserved protein [Function unknown]; Region: COG3589 650150003756 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150003757 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150003758 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 650150003759 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 650150003760 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 650150003761 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 650150003762 alphaNTD homodimer interface [polypeptide binding]; other site 650150003763 alphaNTD - beta interaction site [polypeptide binding]; other site 650150003764 alphaNTD - beta' interaction site [polypeptide binding]; other site 650150003765 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 650150003766 30S ribosomal protein S11; Validated; Region: PRK05309 650150003767 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 650150003768 30S ribosomal protein S13; Region: bact_S13; TIGR03631 650150003769 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 650150003770 rRNA binding site [nucleotide binding]; other site 650150003771 predicted 30S ribosome binding site; other site 650150003772 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 650150003773 active site 650150003774 adenylate kinase; Reviewed; Region: adk; PRK00279 650150003775 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 650150003776 AMP-binding site [chemical binding]; other site 650150003777 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 650150003778 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 650150003779 SecY translocase; Region: SecY; pfam00344 650150003780 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 650150003781 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 650150003782 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 650150003783 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 650150003784 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 650150003785 5S rRNA interface [nucleotide binding]; other site 650150003786 L27 interface [polypeptide binding]; other site 650150003787 L5 interface [polypeptide binding]; other site 650150003788 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 650150003789 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 650150003790 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 650150003791 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 650150003792 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 650150003793 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 650150003794 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 650150003795 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 650150003796 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 650150003797 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 650150003798 RNA binding site [nucleotide binding]; other site 650150003799 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 650150003800 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 650150003801 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 650150003802 23S rRNA interface [nucleotide binding]; other site 650150003803 putative translocon interaction site; other site 650150003804 signal recognition particle (SRP54) interaction site; other site 650150003805 L23 interface [polypeptide binding]; other site 650150003806 trigger factor interaction site; other site 650150003807 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 650150003808 23S rRNA interface [nucleotide binding]; other site 650150003809 5S rRNA interface [nucleotide binding]; other site 650150003810 putative antibiotic binding site [chemical binding]; other site 650150003811 L25 interface [polypeptide binding]; other site 650150003812 L27 interface [polypeptide binding]; other site 650150003813 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 650150003814 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 650150003815 G-X-X-G motif; other site 650150003816 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 650150003817 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 650150003818 putative translocon binding site; other site 650150003819 protein-rRNA interface [nucleotide binding]; other site 650150003820 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 650150003821 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 650150003822 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 650150003823 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 650150003824 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 650150003825 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 650150003826 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 650150003827 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 650150003828 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 650150003829 elongation factor Tu; Reviewed; Region: PRK00049 650150003830 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 650150003831 G1 box; other site 650150003832 GEF interaction site [polypeptide binding]; other site 650150003833 GTP/Mg2+ binding site [chemical binding]; other site 650150003834 Switch I region; other site 650150003835 G2 box; other site 650150003836 G3 box; other site 650150003837 Switch II region; other site 650150003838 G4 box; other site 650150003839 G5 box; other site 650150003840 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 650150003841 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 650150003842 Antibiotic Binding Site [chemical binding]; other site 650150003843 elongation factor G; Reviewed; Region: PRK00007 650150003844 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 650150003845 G1 box; other site 650150003846 putative GEF interaction site [polypeptide binding]; other site 650150003847 GTP/Mg2+ binding site [chemical binding]; other site 650150003848 Switch I region; other site 650150003849 G2 box; other site 650150003850 G3 box; other site 650150003851 Switch II region; other site 650150003852 G4 box; other site 650150003853 G5 box; other site 650150003854 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 650150003855 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 650150003856 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 650150003857 30S ribosomal protein S7; Validated; Region: PRK05302 650150003858 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 650150003859 S17 interaction site [polypeptide binding]; other site 650150003860 S8 interaction site; other site 650150003861 16S rRNA interaction site [nucleotide binding]; other site 650150003862 streptomycin interaction site [chemical binding]; other site 650150003863 23S rRNA interaction site [nucleotide binding]; other site 650150003864 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 650150003865 Domain of unknown function DUF20; Region: UPF0118; pfam01594 650150003866 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 650150003867 Staphylococcal nuclease homologues; Region: SNc; smart00318 650150003868 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 650150003869 Catalytic site; other site 650150003870 FtsX-like permease family; Region: FtsX; pfam02687 650150003871 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150003872 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 650150003873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150003874 FtsX-like permease family; Region: FtsX; pfam02687 650150003875 FtsX-like permease family; Region: FtsX; pfam02687 650150003876 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003877 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150003878 Walker A/P-loop; other site 650150003879 ATP binding site [chemical binding]; other site 650150003880 Q-loop/lid; other site 650150003881 ABC transporter signature motif; other site 650150003882 Walker B; other site 650150003883 D-loop; other site 650150003884 H-loop/switch region; other site 650150003885 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 650150003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150003887 ATP binding site [chemical binding]; other site 650150003888 Mg2+ binding site [ion binding]; other site 650150003889 G-X-G motif; other site 650150003890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150003891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150003892 active site 650150003893 phosphorylation site [posttranslational modification] 650150003894 intermolecular recognition site; other site 650150003895 dimerization interface [polypeptide binding]; other site 650150003896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150003897 DNA binding site [nucleotide binding] 650150003898 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 650150003899 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 650150003900 oligomer interface [polypeptide binding]; other site 650150003901 Cl binding site [ion binding]; other site 650150003902 LexA repressor, pseudogene, truncated by frameshift mutation 650150003903 DNA polymerase IV; Reviewed; Region: PRK03103 650150003904 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 650150003905 active site 650150003906 DNA binding site [nucleotide binding] 650150003907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150003908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150003909 ATP binding site [chemical binding]; other site 650150003910 Mg2+ binding site [ion binding]; other site 650150003911 G-X-G motif; other site 650150003912 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150003913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150003914 active site 650150003915 phosphorylation site [posttranslational modification] 650150003916 intermolecular recognition site; other site 650150003917 LytTr DNA-binding domain; Region: LytTR; smart00850 650150003918 Protein of unknown function DUF262; Region: DUF262; pfam03235 650150003919 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 650150003920 PLD-like domain; Region: PLDc_2; pfam13091 650150003921 putative homodimer interface [polypeptide binding]; other site 650150003922 putative active site [active] 650150003923 catalytic site [active] 650150003924 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 650150003925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150003926 ATP binding site [chemical binding]; other site 650150003927 putative Mg++ binding site [ion binding]; other site 650150003928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003929 nucleotide binding region [chemical binding]; other site 650150003930 ATP-binding site [chemical binding]; other site 650150003931 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 650150003932 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 650150003933 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 650150003934 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 650150003935 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150003937 motif II; other site 650150003938 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150003939 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 650150003940 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 650150003941 oligoendopeptidase F; Region: pepF; TIGR00181 650150003942 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 650150003943 active site 650150003944 Zn binding site [ion binding]; other site 650150003945 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 650150003946 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 650150003947 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 650150003948 active site 650150003949 dimer interface [polypeptide binding]; other site 650150003950 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 650150003951 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 650150003952 active site 650150003953 trimer interface [polypeptide binding]; other site 650150003954 allosteric site; other site 650150003955 active site lid [active] 650150003956 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 650150003957 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 650150003958 PhnA protein; Region: PhnA; pfam03831 650150003959 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 650150003960 active pocket/dimerization site; other site 650150003961 active site 650150003962 phosphorylation site [posttranslational modification] 650150003963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150003965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003966 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 650150003967 substrate binding site [chemical binding]; other site 650150003968 catalytic residues [active] 650150003969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150003970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150003971 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 650150003972 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 650150003973 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150003974 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 650150003975 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 650150003976 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 650150003977 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150003978 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150003979 DNA binding site [nucleotide binding] 650150003980 domain linker motif; other site 650150003981 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 650150003982 putative dimerization interface [polypeptide binding]; other site 650150003983 putative ligand binding site [chemical binding]; other site 650150003984 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 650150003985 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 650150003986 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 650150003987 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 650150003988 active site 650150003989 phosphorylation site [posttranslational modification] 650150003990 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 650150003991 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 650150003992 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 650150003993 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 650150003994 active site 650150003995 intersubunit interface [polypeptide binding]; other site 650150003996 catalytic residue [active] 650150003997 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 650150003998 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 650150003999 substrate binding site [chemical binding]; other site 650150004000 ATP binding site [chemical binding]; other site 650150004001 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 650150004002 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 650150004003 NADP binding site [chemical binding]; other site 650150004004 homodimer interface [polypeptide binding]; other site 650150004005 active site 650150004006 hypothetical protein; Provisional; Region: PRK09273 650150004007 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 650150004008 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 650150004009 HI0933-like protein; Region: HI0933_like; pfam03486 650150004010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 650150004011 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 650150004012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150004013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150004014 homodimer interface [polypeptide binding]; other site 650150004015 catalytic residue [active] 650150004016 VanZ like family; Region: VanZ; cl01971 650150004017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 650150004018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150004019 Coenzyme A binding pocket [chemical binding]; other site 650150004020 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 650150004021 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 650150004022 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 650150004023 putative active site cavity [active] 650150004024 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 650150004025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004026 dimer interface [polypeptide binding]; other site 650150004027 conserved gate region; other site 650150004028 putative PBP binding loops; other site 650150004029 ABC-ATPase subunit interface; other site 650150004030 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150004031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004032 dimer interface [polypeptide binding]; other site 650150004033 conserved gate region; other site 650150004034 putative PBP binding loops; other site 650150004035 ABC-ATPase subunit interface; other site 650150004036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150004037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 650150004038 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150004039 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 650150004040 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 650150004041 putative active site [active] 650150004042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150004043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 650150004044 nucleotide binding site [chemical binding]; other site 650150004045 N-acetylneuraminate lyase; Provisional; Region: PRK04147 650150004046 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 650150004047 inhibitor site; inhibition site 650150004048 active site 650150004049 dimer interface [polypeptide binding]; other site 650150004050 catalytic residue [active] 650150004051 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 650150004052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150004053 motif II; other site 650150004054 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 650150004055 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 650150004056 Putative esterase; Region: Esterase; pfam00756 650150004057 S-formylglutathione hydrolase; Region: PLN02442 650150004058 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 650150004059 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 650150004060 putative deacylase active site [active] 650150004061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150004062 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 650150004063 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 650150004064 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 650150004065 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 650150004066 putative deacylase active site [active] 650150004067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 650150004068 phosphorylation site [posttranslational modification] 650150004069 intermolecular recognition site; other site 650150004070 LytTr DNA-binding domain; Region: LytTR; smart00850 650150004071 Alkylmercury lyase; Region: MerB; pfam03243 650150004072 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 650150004073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150004075 Walker A/P-loop; other site 650150004076 ATP binding site [chemical binding]; other site 650150004077 Q-loop/lid; other site 650150004078 ABC transporter signature motif; other site 650150004079 Walker B; other site 650150004080 D-loop; other site 650150004081 H-loop/switch region; other site 650150004082 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 650150004083 oligomerisation interface [polypeptide binding]; other site 650150004084 mobile loop; other site 650150004085 roof hairpin; other site 650150004086 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 650150004087 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 650150004088 ring oligomerisation interface [polypeptide binding]; other site 650150004089 ATP/Mg binding site [chemical binding]; other site 650150004090 stacking interactions; other site 650150004091 hinge regions; other site 650150004092 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150004093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004094 non-specific DNA binding site [nucleotide binding]; other site 650150004095 salt bridge; other site 650150004096 sequence-specific DNA binding site [nucleotide binding]; other site 650150004097 transposase, pseudogene, truncated by premature stop codon 650150004098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 650150004099 Transposase; Region: HTH_Tnp_1; pfam01527 650150004100 putative transposase OrfB; Reviewed; Region: PHA02517 650150004101 HTH-like domain; Region: HTH_21; pfam13276 650150004102 Integrase core domain; Region: rve; pfam00665 650150004103 Integrase core domain; Region: rve_3; pfam13683 650150004104 Transposase; Region: HTH_Tnp_1; pfam01527 650150004105 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 650150004106 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 650150004107 ligand binding site [chemical binding]; other site 650150004108 flexible hinge region; other site 650150004109 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 650150004110 putative switch regulator; other site 650150004111 non-specific DNA interactions [nucleotide binding]; other site 650150004112 DNA binding site [nucleotide binding] 650150004113 sequence specific DNA binding site [nucleotide binding]; other site 650150004114 putative cAMP binding site [chemical binding]; other site 650150004115 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150004116 metal-binding site [ion binding] 650150004117 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 650150004118 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 650150004119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150004120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 650150004121 Integrase core domain; Region: rve; pfam00665 650150004122 Integrase core domain; Region: rve_3; pfam13683 650150004123 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 650150004124 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 650150004125 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 650150004126 Methyltransferase domain; Region: Methyltransf_26; pfam13659 650150004127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150004128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004129 non-specific DNA binding site [nucleotide binding]; other site 650150004130 salt bridge; other site 650150004131 sequence-specific DNA binding site [nucleotide binding]; other site 650150004132 Putative viral replication protein; Region: Viral_Rep; pfam02407 650150004133 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 650150004134 RNA helicase; Region: RNA_helicase; pfam00910 650150004135 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 650150004136 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 650150004137 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 650150004138 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 650150004139 Int/Topo IB signature motif; other site 650150004140 GMP synthase; Reviewed; Region: guaA; PRK00074 650150004141 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 650150004142 AMP/PPi binding site [chemical binding]; other site 650150004143 candidate oxyanion hole; other site 650150004144 catalytic triad [active] 650150004145 potential glutamine specificity residues [chemical binding]; other site 650150004146 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 650150004147 ATP Binding subdomain [chemical binding]; other site 650150004148 Ligand Binding sites [chemical binding]; other site 650150004149 Dimerization subdomain; other site 650150004150 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 650150004151 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 650150004152 active site 650150004153 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 650150004154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150004155 active site 650150004156 motif I; other site 650150004157 motif II; other site 650150004158 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 650150004159 ornithine cyclodeaminase; Validated; Region: PRK08618 650150004160 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 650150004161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 650150004162 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 650150004163 Predicted transcriptional regulators [Transcription]; Region: COG1378 650150004164 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 650150004165 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 650150004166 C-terminal domain interface [polypeptide binding]; other site 650150004167 sugar binding site [chemical binding]; other site 650150004168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 650150004169 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150004170 metal-binding site [ion binding] 650150004171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150004172 Soluble P-type ATPase [General function prediction only]; Region: COG4087 650150004173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 650150004174 dimerization interface [polypeptide binding]; other site 650150004175 putative DNA binding site [nucleotide binding]; other site 650150004176 putative Zn2+ binding site [ion binding]; other site 650150004177 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 650150004178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150004179 active site 650150004180 motif I; other site 650150004181 motif II; other site 650150004182 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 650150004183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 650150004184 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 650150004185 catalytic triad [active] 650150004186 active site nucleophile [active] 650150004187 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150004188 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 650150004189 putative oligomer interface [polypeptide binding]; other site 650150004190 putative active site [active] 650150004191 metal binding site [ion binding]; metal-binding site 650150004192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150004193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150004194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150004195 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 650150004196 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 650150004197 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 650150004198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150004199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 650150004200 active site 650150004201 phosphorylation site [posttranslational modification] 650150004202 intermolecular recognition site; other site 650150004203 dimerization interface [polypeptide binding]; other site 650150004204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150004205 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 650150004206 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150004207 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 650150004208 Uncharacterized conserved protein [Function unknown]; Region: COG2013 650150004209 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 650150004210 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 650150004211 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 650150004212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 650150004213 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 650150004214 putative L-serine binding site [chemical binding]; other site 650150004215 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 650150004216 homotrimer interaction site [polypeptide binding]; other site 650150004217 putative active site [active] 650150004218 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 650150004219 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150004220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150004221 homodimer interface [polypeptide binding]; other site 650150004222 catalytic residue [active] 650150004223 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150004224 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 650150004225 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 650150004226 putative active site [active] 650150004227 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 650150004228 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 650150004229 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 650150004230 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 650150004231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 650150004232 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 650150004233 DNA binding residues [nucleotide binding] 650150004234 drug binding residues [chemical binding]; other site 650150004235 dimer interface [polypeptide binding]; other site 650150004236 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 650150004237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150004238 active site 650150004239 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 650150004240 enolase; Provisional; Region: eno; PRK00077 650150004241 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 650150004242 dimer interface [polypeptide binding]; other site 650150004243 metal binding site [ion binding]; metal-binding site 650150004244 substrate binding pocket [chemical binding]; other site 650150004245 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 650150004246 triosephosphate isomerase; Provisional; Region: PRK14565 650150004247 substrate binding site [chemical binding]; other site 650150004248 dimer interface [polypeptide binding]; other site 650150004249 catalytic triad [active] 650150004250 Phosphoglycerate kinase; Region: PGK; pfam00162 650150004251 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 650150004252 substrate binding site [chemical binding]; other site 650150004253 hinge regions; other site 650150004254 ADP binding site [chemical binding]; other site 650150004255 catalytic site [active] 650150004256 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 650150004257 metal-binding site [ion binding] 650150004258 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150004259 metal-binding site [ion binding] 650150004260 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 650150004261 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150004262 metal-binding site [ion binding] 650150004263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150004264 Soluble P-type ATPase [General function prediction only]; Region: COG4087 650150004265 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 650150004266 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 650150004267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150004268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150004269 Transposase; Region: HTH_Tnp_1; cl17663 650150004270 putative transposase OrfB; Reviewed; Region: PHA02517 650150004271 HTH-like domain; Region: HTH_21; pfam13276 650150004272 Integrase core domain; Region: rve; pfam00665 650150004273 Integrase core domain; Region: rve_3; pfam13683 650150004274 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 650150004275 active site 650150004276 tetramer interface [polypeptide binding]; other site 650150004277 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 650150004278 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 650150004279 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 650150004280 putative catalytic cysteine [active] 650150004281 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 650150004282 putative active site [active] 650150004283 metal binding site [ion binding]; metal-binding site 650150004284 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 650150004285 active site 650150004286 catalytic residues [active] 650150004287 OsmC-like protein; Region: OsmC; cl00767 650150004288 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004289 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 650150004290 Walker A/P-loop; other site 650150004291 ATP binding site [chemical binding]; other site 650150004292 Q-loop/lid; other site 650150004293 ABC transporter signature motif; other site 650150004294 Walker B; other site 650150004295 D-loop; other site 650150004296 H-loop/switch region; other site 650150004297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004298 dimer interface [polypeptide binding]; other site 650150004299 conserved gate region; other site 650150004300 ABC-ATPase subunit interface; other site 650150004301 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 650150004302 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 650150004303 asparagine synthetase AsnA; Provisional; Region: PRK05425 650150004304 motif 1; other site 650150004305 dimer interface [polypeptide binding]; other site 650150004306 active site 650150004307 motif 2; other site 650150004308 motif 3; other site 650150004309 YibE/F-like protein; Region: YibE_F; cl02259 650150004310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150004311 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150004312 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004313 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 650150004314 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 650150004315 metal binding site [ion binding]; metal-binding site 650150004316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150004317 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004318 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 650150004319 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 650150004320 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 650150004321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 650150004322 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150004323 FtsX-like permease family; Region: FtsX; pfam02687 650150004324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004325 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150004326 Walker A/P-loop; other site 650150004327 ATP binding site [chemical binding]; other site 650150004328 Q-loop/lid; other site 650150004329 ABC transporter signature motif; other site 650150004330 Walker B; other site 650150004331 D-loop; other site 650150004332 H-loop/switch region; other site 650150004333 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150004334 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150004335 pyruvate phosphate dikinase; Provisional; Region: PRK09279 650150004336 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 650150004337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 650150004338 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 650150004339 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 650150004340 UDP-glucose 4-epimerase; Region: PLN02240 650150004341 NAD binding site [chemical binding]; other site 650150004342 homodimer interface [polypeptide binding]; other site 650150004343 active site 650150004344 substrate binding site [chemical binding]; other site 650150004345 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 650150004346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 650150004347 ABC-ATPase subunit interface; other site 650150004348 dimer interface [polypeptide binding]; other site 650150004349 putative PBP binding regions; other site 650150004350 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 650150004351 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 650150004352 ABC-ATPase subunit interface; other site 650150004353 dimer interface [polypeptide binding]; other site 650150004354 putative PBP binding regions; other site 650150004355 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 650150004356 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 650150004357 Walker A/P-loop; other site 650150004358 ATP binding site [chemical binding]; other site 650150004359 Q-loop/lid; other site 650150004360 ABC transporter signature motif; other site 650150004361 Walker B; other site 650150004362 D-loop; other site 650150004363 H-loop/switch region; other site 650150004364 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 650150004365 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 650150004366 putative ligand binding residues [chemical binding]; other site 650150004367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004369 Walker A/P-loop; other site 650150004370 ATP binding site [chemical binding]; other site 650150004371 Q-loop/lid; other site 650150004372 ABC transporter signature motif; other site 650150004373 Walker B; other site 650150004374 D-loop; other site 650150004375 H-loop/switch region; other site 650150004376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 650150004377 putative DNA binding site [nucleotide binding]; other site 650150004378 dimerization interface [polypeptide binding]; other site 650150004379 putative Zn2+ binding site [ion binding]; other site 650150004380 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004381 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150004382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004383 Walker A/P-loop; other site 650150004384 ATP binding site [chemical binding]; other site 650150004385 Q-loop/lid; other site 650150004386 ABC transporter signature motif; other site 650150004387 Walker B; other site 650150004388 D-loop; other site 650150004389 H-loop/switch region; other site 650150004390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150004392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004393 Walker A/P-loop; other site 650150004394 ATP binding site [chemical binding]; other site 650150004395 Q-loop/lid; other site 650150004396 ABC transporter signature motif; other site 650150004397 Walker B; other site 650150004398 D-loop; other site 650150004399 H-loop/switch region; other site 650150004400 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150004401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150004402 RNA binding surface [nucleotide binding]; other site 650150004403 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 650150004404 active site 650150004405 uracil binding [chemical binding]; other site 650150004406 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150004407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004408 Walker A/P-loop; other site 650150004409 ATP binding site [chemical binding]; other site 650150004410 Q-loop/lid; other site 650150004411 ABC transporter signature motif; other site 650150004412 Walker B; other site 650150004413 D-loop; other site 650150004414 H-loop/switch region; other site 650150004415 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150004416 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150004417 Walker A/P-loop; other site 650150004418 ATP binding site [chemical binding]; other site 650150004419 Q-loop/lid; other site 650150004420 ABC transporter signature motif; other site 650150004421 Walker B; other site 650150004422 D-loop; other site 650150004423 H-loop/switch region; other site 650150004424 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 650150004425 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 650150004426 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 650150004427 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 650150004428 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004430 Walker A/P-loop; other site 650150004431 ATP binding site [chemical binding]; other site 650150004432 Q-loop/lid; other site 650150004433 ABC transporter signature motif; other site 650150004434 Walker B; other site 650150004435 D-loop; other site 650150004436 H-loop/switch region; other site 650150004437 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 650150004438 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 650150004439 putative active site [active] 650150004440 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 650150004441 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 650150004442 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 650150004443 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 650150004444 active site 650150004445 phosphorylation site [posttranslational modification] 650150004446 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 650150004447 active pocket/dimerization site; other site 650150004448 active site 650150004449 phosphorylation site [posttranslational modification] 650150004450 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 650150004451 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 650150004452 DNA interaction; other site 650150004453 Metal-binding active site; metal-binding site 650150004454 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 650150004455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150004456 Walker A motif; other site 650150004457 ATP binding site [chemical binding]; other site 650150004458 Walker B motif; other site 650150004459 arginine finger; other site 650150004460 Transcriptional antiterminator [Transcription]; Region: COG3933 650150004461 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 650150004462 active pocket/dimerization site; other site 650150004463 active site 650150004464 phosphorylation site [posttranslational modification] 650150004465 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 650150004466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 650150004467 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 650150004468 active site turn [active] 650150004469 phosphorylation site [posttranslational modification] 650150004470 transcriptional antiterminator BglG; Provisional; Region: PRK09772 650150004471 CAT RNA binding domain; Region: CAT_RBD; smart01061 650150004472 PRD domain; Region: PRD; pfam00874 650150004473 PRD domain; Region: PRD; pfam00874 650150004474 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 650150004475 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 650150004476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150004477 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 650150004478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150004479 motif II; other site 650150004480 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150004481 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 650150004482 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 650150004483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 650150004485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 650150004486 dimerization interface [polypeptide binding]; other site 650150004487 butyrate kinase; Provisional; Region: PRK03011 650150004488 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 650150004489 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 650150004490 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 650150004491 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 650150004492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 650150004493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 650150004494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150004495 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 650150004496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150004497 E3 interaction surface; other site 650150004498 lipoyl attachment site [posttranslational modification]; other site 650150004499 e3 binding domain; Region: E3_binding; pfam02817 650150004500 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 650150004501 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 650150004502 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 650150004503 alpha subunit interface [polypeptide binding]; other site 650150004504 TPP binding site [chemical binding]; other site 650150004505 heterodimer interface [polypeptide binding]; other site 650150004506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150004507 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 650150004508 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 650150004509 TPP-binding site [chemical binding]; other site 650150004510 tetramer interface [polypeptide binding]; other site 650150004511 heterodimer interface [polypeptide binding]; other site 650150004512 phosphorylation loop region [posttranslational modification] 650150004513 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004514 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150004515 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 650150004516 Walker A/P-loop; other site 650150004517 ATP binding site [chemical binding]; other site 650150004518 Q-loop/lid; other site 650150004519 ABC transporter signature motif; other site 650150004520 Walker B; other site 650150004521 D-loop; other site 650150004522 H-loop/switch region; other site 650150004523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 650150004525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004526 Walker A/P-loop; other site 650150004527 ATP binding site [chemical binding]; other site 650150004528 Q-loop/lid; other site 650150004529 ABC transporter signature motif; other site 650150004530 Walker B; other site 650150004531 D-loop; other site 650150004532 H-loop/switch region; other site 650150004533 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 650150004534 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 650150004535 DNA binding residues [nucleotide binding] 650150004536 dimer interface [polypeptide binding]; other site 650150004537 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 650150004538 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004539 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150004540 DNA binding residues [nucleotide binding] 650150004541 Integrase core domain; Region: rve; pfam00665 650150004542 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150004543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 650150004544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150004545 Predicted membrane protein [Function unknown]; Region: COG1288 650150004546 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 650150004547 hypothetical protein; Provisional; Region: PRK07205 650150004548 active site 650150004549 metal binding site [ion binding]; metal-binding site 650150004550 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 650150004551 nudix motif; other site 650150004552 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 650150004553 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 650150004555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004556 dimerization interface [polypeptide binding]; other site 650150004557 YceG-like family; Region: YceG; pfam02618 650150004558 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 650150004559 dimerization interface [polypeptide binding]; other site 650150004560 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 650150004561 CPxP motif; other site 650150004562 Domain of unknown function (DUF386); Region: DUF386; cl01047 650150004563 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 650150004564 Acyltransferase family; Region: Acyl_transf_3; pfam01757 650150004565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150004566 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150004567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150004568 active site 650150004569 phosphorylation site [posttranslational modification] 650150004570 intermolecular recognition site; other site 650150004571 dimerization interface [polypeptide binding]; other site 650150004572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150004573 DNA binding site [nucleotide binding] 650150004574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150004575 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 650150004576 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150004577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 650150004578 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 650150004579 Ligand Binding Site [chemical binding]; other site 650150004580 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 650150004581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 650150004582 FeS/SAM binding site; other site 650150004583 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004584 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004585 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004586 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004587 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004588 Cna protein B-type domain; Region: Cna_B; pfam05738 650150004589 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 650150004590 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 650150004591 putative homodimer interface [polypeptide binding]; other site 650150004592 putative ligand binding site [chemical binding]; other site 650150004593 putative NAD binding site [chemical binding]; other site 650150004594 catalytic site [active] 650150004595 Membrane transport protein; Region: Mem_trans; cl09117 650150004596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150004597 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 650150004598 active site 650150004599 nucleotide binding site [chemical binding]; other site 650150004600 HIGH motif; other site 650150004601 KMSKS motif; other site 650150004602 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 650150004603 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 650150004604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 650150004605 active site 650150004606 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 650150004607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150004608 putative ADP-binding pocket [chemical binding]; other site 650150004609 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 650150004610 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 650150004611 Bacterial sugar transferase; Region: Bac_transf; pfam02397 650150004612 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 650150004613 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 650150004614 inhibitor-cofactor binding pocket; inhibition site 650150004615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150004616 catalytic residue [active] 650150004617 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 650150004618 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 650150004619 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 650150004620 NAD(P) binding site [chemical binding]; other site 650150004621 homodimer interface [polypeptide binding]; other site 650150004622 substrate binding site [chemical binding]; other site 650150004623 active site 650150004624 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 650150004625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004626 non-specific DNA binding site [nucleotide binding]; other site 650150004627 salt bridge; other site 650150004628 sequence-specific DNA binding site [nucleotide binding]; other site 650150004629 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 650150004630 Acyltransferase family; Region: Acyl_transf_3; pfam01757 650150004631 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 650150004632 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 650150004633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150004635 Walker A/P-loop; other site 650150004636 ATP binding site [chemical binding]; other site 650150004637 Q-loop/lid; other site 650150004638 ABC transporter signature motif; other site 650150004639 Walker B; other site 650150004640 D-loop; other site 650150004641 H-loop/switch region; other site 650150004642 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 650150004643 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150004644 FtsX-like permease family; Region: FtsX; pfam02687 650150004645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150004646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150004647 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004648 Integrase core domain; Region: rve; pfam00665 650150004649 gamma-glutamyl kinase; Provisional; Region: PRK05429 650150004650 Integrase core domain; Region: rve_3; cl15866 650150004651 Predicted membrane protein [Function unknown]; Region: COG2323 650150004652 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 650150004653 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 650150004654 HTH-like domain; Region: HTH_21; pfam13276 650150004655 Integrase core domain; Region: rve; pfam00665 650150004656 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 650150004657 active site 650150004658 Predicted membrane protein [Function unknown]; Region: COG2364 650150004659 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 650150004660 active site 650150004661 tetramer interface [polypeptide binding]; other site 650150004662 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150004663 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150004664 TM-ABC transporter signature motif; other site 650150004665 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 650150004666 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150004667 TM-ABC transporter signature motif; other site 650150004668 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 650150004669 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 650150004670 Walker A/P-loop; other site 650150004671 ATP binding site [chemical binding]; other site 650150004672 Q-loop/lid; other site 650150004673 ABC transporter signature motif; other site 650150004674 Walker B; other site 650150004675 D-loop; other site 650150004676 H-loop/switch region; other site 650150004677 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 650150004678 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150004679 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150004680 ligand binding site [chemical binding]; other site 650150004681 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 650150004682 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 650150004683 substrate binding site [chemical binding]; other site 650150004684 dimer interface [polypeptide binding]; other site 650150004685 ATP binding site [chemical binding]; other site 650150004686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150004687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150004688 DNA binding site [nucleotide binding] 650150004689 domain linker motif; other site 650150004690 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 650150004691 ligand binding site [chemical binding]; other site 650150004692 dimerization interface [polypeptide binding]; other site 650150004693 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 650150004694 potential frameshift: common BLAST hit: gi|49484823|ref|YP_042047.1| transposase 650150004695 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004696 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004697 Integrase core domain; Region: rve; pfam00665 650150004698 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 650150004699 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150004700 active site 650150004701 ATP binding site [chemical binding]; other site 650150004702 substrate binding site [chemical binding]; other site 650150004703 dimer interface [polypeptide binding]; other site 650150004704 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150004705 FtsX-like permease family; Region: FtsX; pfam02687 650150004706 FtsX-like permease family; Region: FtsX; pfam02687 650150004707 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004708 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 650150004709 Walker A/P-loop; other site 650150004710 ATP binding site [chemical binding]; other site 650150004711 Q-loop/lid; other site 650150004712 ABC transporter signature motif; other site 650150004713 Walker B; other site 650150004714 D-loop; other site 650150004715 H-loop/switch region; other site 650150004716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150004717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 650150004718 phosphorylation site [posttranslational modification] 650150004719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150004720 ATP binding site [chemical binding]; other site 650150004721 Mg2+ binding site [ion binding]; other site 650150004722 G-X-G motif; other site 650150004723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150004724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 650150004725 active site 650150004726 phosphorylation site [posttranslational modification] 650150004727 intermolecular recognition site; other site 650150004728 dimerization interface [polypeptide binding]; other site 650150004729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 650150004730 DNA binding site [nucleotide binding] 650150004731 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 650150004732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 650150004733 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150004734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004735 dimer interface [polypeptide binding]; other site 650150004736 conserved gate region; other site 650150004737 putative PBP binding loops; other site 650150004738 ABC-ATPase subunit interface; other site 650150004739 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150004740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004741 dimer interface [polypeptide binding]; other site 650150004742 conserved gate region; other site 650150004743 putative PBP binding loops; other site 650150004744 ABC-ATPase subunit interface; other site 650150004745 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 650150004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004747 Walker A/P-loop; other site 650150004748 ATP binding site [chemical binding]; other site 650150004749 Q-loop/lid; other site 650150004750 ABC transporter signature motif; other site 650150004751 Walker B; other site 650150004752 D-loop; other site 650150004753 H-loop/switch region; other site 650150004754 TOBE domain; Region: TOBE_2; pfam08402 650150004755 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 650150004756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004757 non-specific DNA binding site [nucleotide binding]; other site 650150004758 salt bridge; other site 650150004759 sequence-specific DNA binding site [nucleotide binding]; other site 650150004760 Cupin domain; Region: Cupin_2; pfam07883 650150004761 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 650150004762 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 650150004763 catalytic residues [active] 650150004764 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 650150004765 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 650150004766 Transcriptional regulator [Transcription]; Region: LytR; COG1316 650150004767 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 650150004768 PASTA domain; Region: PASTA; smart00740 650150004769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 650150004770 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 650150004771 active site 650150004772 metal binding site [ion binding]; metal-binding site 650150004773 homotetramer interface [polypeptide binding]; other site 650150004774 Transcriptional regulator [Transcription]; Region: LytR; COG1316 650150004775 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 650150004776 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150004777 Walker A/P-loop; other site 650150004778 ATP binding site [chemical binding]; other site 650150004779 Q-loop/lid; other site 650150004780 ABC transporter signature motif; other site 650150004781 Walker B; other site 650150004782 D-loop; other site 650150004783 H-loop/switch region; other site 650150004784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150004785 DNA-binding site [nucleotide binding]; DNA binding site 650150004786 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 650150004787 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 650150004788 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 650150004789 active site 650150004790 HIGH motif; other site 650150004791 KMSK motif region; other site 650150004792 tRNA binding surface [nucleotide binding]; other site 650150004793 DALR anticodon binding domain; Region: DALR_1; smart00836 650150004794 anticodon binding site; other site 650150004795 EDD domain protein, DegV family; Region: DegV; TIGR00762 650150004796 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 650150004797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 650150004799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 650150004800 dimerization interface [polypeptide binding]; other site 650150004801 tyrosine decarboxylase; Region: PLN02880 650150004802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 650150004803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150004804 catalytic residue [active] 650150004805 Predicted flavoprotein [General function prediction only]; Region: COG0431 650150004806 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 650150004807 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 650150004808 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 650150004809 substrate binding pocket [chemical binding]; other site 650150004810 membrane-bound complex binding site; other site 650150004811 hinge residues; other site 650150004812 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 650150004813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150004814 dimer interface [polypeptide binding]; other site 650150004815 conserved gate region; other site 650150004816 putative PBP binding loops; other site 650150004817 ABC-ATPase subunit interface; other site 650150004818 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 650150004819 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 650150004820 Walker A/P-loop; other site 650150004821 ATP binding site [chemical binding]; other site 650150004822 Q-loop/lid; other site 650150004823 ABC transporter signature motif; other site 650150004824 Walker B; other site 650150004825 D-loop; other site 650150004826 H-loop/switch region; other site 650150004827 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 650150004828 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150004829 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150004830 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 650150004831 ligand binding site [chemical binding]; other site 650150004832 active site 650150004833 UGI interface [polypeptide binding]; other site 650150004834 catalytic site [active] 650150004835 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 650150004836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150004837 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 650150004838 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 650150004839 homotetramer interface [polypeptide binding]; other site 650150004840 FMN binding site [chemical binding]; other site 650150004841 homodimer contacts [polypeptide binding]; other site 650150004842 putative active site [active] 650150004843 putative substrate binding site [chemical binding]; other site 650150004844 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 650150004845 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 650150004846 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150004847 diphosphomevalonate decarboxylase; Region: PLN02407 650150004848 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 650150004849 mevalonate kinase; Region: mevalon_kin; TIGR00549 650150004850 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 650150004851 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150004852 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 650150004853 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 650150004854 putative homodimer interface [polypeptide binding]; other site 650150004855 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 650150004856 heterodimer interface [polypeptide binding]; other site 650150004857 homodimer interface [polypeptide binding]; other site 650150004858 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 650150004859 RNA polymerase factor sigma-70; Validated; Region: PRK08295 650150004860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 650150004861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 650150004862 DNA binding residues [nucleotide binding] 650150004863 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 650150004864 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 650150004865 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 650150004866 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 650150004867 active site 650150004868 metal binding site [ion binding]; metal-binding site 650150004869 dimerization interface [polypeptide binding]; other site 650150004870 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 650150004871 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 650150004872 active site 650150004873 HIGH motif; other site 650150004874 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 650150004875 KMSKS motif; other site 650150004876 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 650150004877 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 650150004878 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 650150004879 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 650150004880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 650150004881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 650150004882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 650150004883 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 650150004884 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 650150004885 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 650150004886 phosphate binding site [ion binding]; other site 650150004887 putative substrate binding pocket [chemical binding]; other site 650150004888 dimer interface [polypeptide binding]; other site 650150004889 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 650150004890 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 650150004891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 650150004892 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 650150004893 pyrophosphatase PpaX; Provisional; Region: PRK13288 650150004894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 650150004895 motif II; other site 650150004896 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 650150004897 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 650150004898 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 650150004899 Hpr binding site; other site 650150004900 active site 650150004901 homohexamer subunit interaction site [polypeptide binding]; other site 650150004902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 650150004903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 650150004904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 650150004905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 650150004906 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 650150004907 excinuclease ABC subunit B; Provisional; Region: PRK05298 650150004908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150004909 ATP binding site [chemical binding]; other site 650150004910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004911 nucleotide binding region [chemical binding]; other site 650150004912 ATP-binding site [chemical binding]; other site 650150004913 Ultra-violet resistance protein B; Region: UvrB; pfam12344 650150004914 UvrB/uvrC motif; Region: UVR; pfam02151 650150004915 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 650150004916 C-terminal peptidase (prc); Region: prc; TIGR00225 650150004917 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 650150004918 protein binding site [polypeptide binding]; other site 650150004919 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 650150004920 Catalytic dyad [active] 650150004921 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 650150004922 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 650150004923 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004924 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 650150004925 DNA binding residues [nucleotide binding] 650150004926 Integrase core domain; Region: rve; pfam00665 650150004927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150004928 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 650150004929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150004930 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004931 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 650150004932 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 650150004933 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004934 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 650150004935 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 650150004936 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 650150004937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 650150004938 Walker A/P-loop; other site 650150004939 ATP binding site [chemical binding]; other site 650150004940 Q-loop/lid; other site 650150004941 ABC transporter signature motif; other site 650150004942 Walker B; other site 650150004943 D-loop; other site 650150004944 H-loop/switch region; other site 650150004945 Uncharacterized conserved protein [Function unknown]; Region: COG1284 650150004946 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150004947 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 650150004948 peptide chain release factor 2; Validated; Region: prfB; PRK00578 650150004949 This domain is found in peptide chain release factors; Region: PCRF; smart00937 650150004950 RF-1 domain; Region: RF-1; pfam00472 650150004951 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 650150004952 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 650150004953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 650150004954 nucleotide binding region [chemical binding]; other site 650150004955 ATP-binding site [chemical binding]; other site 650150004956 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 650150004957 DNA-binding site [nucleotide binding]; DNA binding site 650150004958 RNA-binding motif; other site 650150004959 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 650150004960 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150004961 ATP binding site [chemical binding]; other site 650150004962 putative Mg++ binding site [ion binding]; other site 650150004963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004964 nucleotide binding region [chemical binding]; other site 650150004965 ATP-binding site [chemical binding]; other site 650150004966 HflC protein; Region: hflC; TIGR01932 650150004967 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 650150004968 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 650150004969 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 650150004970 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 650150004971 active site 650150004972 catalytic site [active] 650150004973 substrate binding site [chemical binding]; other site 650150004974 heat shock protein 90; Provisional; Region: PRK05218 650150004975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150004976 ATP binding site [chemical binding]; other site 650150004977 Mg2+ binding site [ion binding]; other site 650150004978 G-X-G motif; other site 650150004979 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 650150004980 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 650150004981 Cl- selectivity filter; other site 650150004982 Cl- binding residues [ion binding]; other site 650150004983 pore gating glutamate residue; other site 650150004984 dimer interface [polypeptide binding]; other site 650150004985 H+/Cl- coupling transport residue; other site 650150004986 TrkA-C domain; Region: TrkA_C; pfam02080 650150004987 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 650150004988 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150004989 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 650150004990 HTH domain; Region: HTH_11; pfam08279 650150004991 3H domain; Region: 3H; pfam02829 650150004992 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 650150004993 ArsC family; Region: ArsC; pfam03960 650150004994 putative ArsC-like catalytic residues; other site 650150004995 putative TRX-like catalytic residues [active] 650150004996 hypothetical protein; Validated; Region: PRK02101 650150004997 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 650150004998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150004999 NAD(P) binding site [chemical binding]; other site 650150005000 active site 650150005001 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 650150005002 nudix motif; other site 650150005003 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 650150005004 mRNA/rRNA interface [nucleotide binding]; other site 650150005005 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 650150005006 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 650150005007 L7/L12 interface [polypeptide binding]; other site 650150005008 23S rRNA interface [nucleotide binding]; other site 650150005009 L25 interface [polypeptide binding]; other site 650150005010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 650150005011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150005012 Coenzyme A binding pocket [chemical binding]; other site 650150005013 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 650150005014 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 650150005015 TPP-binding site [chemical binding]; other site 650150005016 dimer interface [polypeptide binding]; other site 650150005017 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 650150005018 PYR/PP interface [polypeptide binding]; other site 650150005019 dimer interface [polypeptide binding]; other site 650150005020 TPP binding site [chemical binding]; other site 650150005021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150005022 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 650150005023 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 650150005024 active site 650150005025 substrate binding site [chemical binding]; other site 650150005026 metal binding site [ion binding]; metal-binding site 650150005027 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 650150005028 dimerization domain swap beta strand [polypeptide binding]; other site 650150005029 regulatory protein interface [polypeptide binding]; other site 650150005030 active site 650150005031 regulatory phosphorylation site [posttranslational modification]; other site 650150005032 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 650150005033 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 650150005034 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 650150005035 protein binding site [polypeptide binding]; other site 650150005036 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: COG2248 650150005037 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 650150005038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150005039 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 650150005040 G5 domain; Region: G5; pfam07501 650150005041 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150005042 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150005043 Lysin motif; Region: LysM; smart00257 650150005044 G5 domain; Region: G5; pfam07501 650150005045 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150005046 replicative DNA helicase; Region: DnaB; TIGR00665 650150005047 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 650150005048 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 650150005049 Walker A motif; other site 650150005050 ATP binding site [chemical binding]; other site 650150005051 Walker B motif; other site 650150005052 DNA binding loops [nucleotide binding] 650150005053 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 650150005054 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 650150005055 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 650150005056 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 650150005057 DHH family; Region: DHH; pfam01368 650150005058 DHHA1 domain; Region: DHHA1; pfam02272 650150005059 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 650150005060 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 650150005061 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 650150005062 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 650150005063 dimer interface [polypeptide binding]; other site 650150005064 ssDNA binding site [nucleotide binding]; other site 650150005065 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150005066 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 650150005067 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 650150005068 substrate binding site; other site 650150005069 dimer interface; other site 650150005070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150005071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 650150005072 LysR substrate binding domain; Region: LysR_substrate; pfam03466 650150005073 dimerization interface [polypeptide binding]; other site 650150005074 Chromate transporter; Region: Chromate_transp; pfam02417 650150005075 Chromate transporter; Region: Chromate_transp; pfam02417 650150005076 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 650150005077 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 650150005078 dimer interface [polypeptide binding]; other site 650150005079 putative anticodon binding site; other site 650150005080 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 650150005081 motif 1; other site 650150005082 active site 650150005083 motif 2; other site 650150005084 motif 3; other site 650150005085 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 650150005086 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 650150005087 dimerization interface [polypeptide binding]; other site 650150005088 domain crossover interface; other site 650150005089 redox-dependent activation switch; other site 650150005090 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 650150005091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150005092 Walker A motif; other site 650150005093 ATP binding site [chemical binding]; other site 650150005094 Walker B motif; other site 650150005095 arginine finger; other site 650150005096 Peptidase family M41; Region: Peptidase_M41; pfam01434 650150005097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150005098 active site 650150005099 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 650150005100 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 650150005101 Ligand Binding Site [chemical binding]; other site 650150005102 TilS substrate C-terminal domain; Region: TilS_C; smart00977 650150005103 rod shape-determining protein Mbl; Provisional; Region: PRK13928 650150005104 MreB and similar proteins; Region: MreB_like; cd10225 650150005105 nucleotide binding site [chemical binding]; other site 650150005106 Mg binding site [ion binding]; other site 650150005107 putative protofilament interaction site [polypeptide binding]; other site 650150005108 RodZ interaction site [polypeptide binding]; other site 650150005109 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 650150005110 sodium/hydrogen exchanger, pseudogene, truncated by premature stop codon 650150005111 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 650150005112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150005113 active site 650150005114 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 650150005115 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 650150005116 dimer interface [polypeptide binding]; other site 650150005117 active site 650150005118 glycine-pyridoxal phosphate binding site [chemical binding]; other site 650150005119 folate binding site [chemical binding]; other site 650150005120 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 650150005121 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 650150005122 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 650150005123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150005124 S-adenosylmethionine binding site [chemical binding]; other site 650150005125 peptide chain release factor 1; Validated; Region: prfA; PRK00591 650150005126 PCRF domain; Region: PCRF; pfam03462 650150005127 RF-1 domain; Region: RF-1; pfam00472 650150005128 thymidine kinase; Provisional; Region: PRK04296 650150005129 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 650150005130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150005131 Coenzyme A binding pocket [chemical binding]; other site 650150005132 amino acid transporter; Region: 2A0306; TIGR00909 650150005133 Spore germination protein; Region: Spore_permease; cl17796 650150005134 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 650150005135 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 650150005136 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 650150005137 Uncharacterized conserved protein [Function unknown]; Region: COG2966 650150005138 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 650150005139 Predicted transcriptional regulators [Transcription]; Region: COG1695 650150005140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 650150005141 putative DNA binding site [nucleotide binding]; other site 650150005142 putative Zn2+ binding site [ion binding]; other site 650150005143 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 650150005144 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 650150005145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 650150005146 FeS/SAM binding site; other site 650150005147 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 650150005148 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 650150005149 hinge; other site 650150005150 active site 650150005151 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 650150005152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150005153 dimer interface [polypeptide binding]; other site 650150005154 conserved gate region; other site 650150005155 ABC-ATPase subunit interface; other site 650150005156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150005157 dimer interface [polypeptide binding]; other site 650150005158 conserved gate region; other site 650150005159 putative PBP binding loops; other site 650150005160 ABC-ATPase subunit interface; other site 650150005161 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 650150005162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 650150005163 Walker A/P-loop; other site 650150005164 ATP binding site [chemical binding]; other site 650150005165 Q-loop/lid; other site 650150005166 ABC transporter signature motif; other site 650150005167 Walker B; other site 650150005168 D-loop; other site 650150005169 H-loop/switch region; other site 650150005170 FOG: CBS domain [General function prediction only]; Region: COG0517 650150005171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 650150005172 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 650150005173 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 650150005174 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 650150005175 intersubunit interface [polypeptide binding]; other site 650150005176 active site 650150005177 zinc binding site [ion binding]; other site 650150005178 Na+ binding site [ion binding]; other site 650150005179 CTP synthetase; Validated; Region: pyrG; PRK05380 650150005180 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 650150005181 Catalytic site [active] 650150005182 active site 650150005183 UTP binding site [chemical binding]; other site 650150005184 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 650150005185 active site 650150005186 putative oxyanion hole; other site 650150005187 catalytic triad [active] 650150005188 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 650150005189 proline aminopeptidase P II; Provisional; Region: PRK10879 650150005190 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 650150005191 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 650150005192 active site 650150005193 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 650150005194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150005195 Zn2+ binding site [ion binding]; other site 650150005196 Mg2+ binding site [ion binding]; other site 650150005197 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 650150005198 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 650150005199 active site 650150005200 HIGH motif; other site 650150005201 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 650150005202 active site 650150005203 KMSKS motif; other site 650150005204 putative acyltransferase; Provisional; Region: PRK05790 650150005205 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 650150005206 dimer interface [polypeptide binding]; other site 650150005207 active site 650150005208 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 650150005209 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 650150005210 dimer interface [polypeptide binding]; other site 650150005211 active site 650150005212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 650150005213 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 650150005214 active site 650150005215 metal binding site [ion binding]; metal-binding site 650150005216 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 650150005217 Protein of unknown function (DUF970); Region: DUF970; pfam06153 650150005218 GTP-binding protein YchF; Reviewed; Region: PRK09601 650150005219 YchF GTPase; Region: YchF; cd01900 650150005220 G1 box; other site 650150005221 GTP/Mg2+ binding site [chemical binding]; other site 650150005222 Switch I region; other site 650150005223 G2 box; other site 650150005224 Switch II region; other site 650150005225 G3 box; other site 650150005226 G4 box; other site 650150005227 G5 box; other site 650150005228 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 650150005229 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 650150005230 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 650150005231 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 650150005232 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 650150005233 homodimer interface [polypeptide binding]; other site 650150005234 NADP binding site [chemical binding]; other site 650150005235 substrate binding site [chemical binding]; other site 650150005236 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 650150005237 putative active site [active] 650150005238 dimerization interface [polypeptide binding]; other site 650150005239 putative tRNAtyr binding site [nucleotide binding]; other site 650150005240 recombination factor protein RarA; Reviewed; Region: PRK13342 650150005241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 650150005242 Walker A motif; other site 650150005243 ATP binding site [chemical binding]; other site 650150005244 Walker B motif; other site 650150005245 arginine finger; other site 650150005246 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 650150005247 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 650150005248 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 650150005249 NADP binding site [chemical binding]; other site 650150005250 dimer interface [polypeptide binding]; other site 650150005251 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 650150005252 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 650150005253 ATP binding site [chemical binding]; other site 650150005254 Mg++ binding site [ion binding]; other site 650150005255 motif III; other site 650150005256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150005257 nucleotide binding region [chemical binding]; other site 650150005258 ATP-binding site [chemical binding]; other site 650150005259 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 650150005260 RNA binding site [nucleotide binding]; other site 650150005261 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 650150005262 active site 650150005263 putative catalytic site [active] 650150005264 DNA binding site [nucleotide binding] 650150005265 putative phosphate binding site [ion binding]; other site 650150005266 metal binding site A [ion binding]; metal-binding site 650150005267 AP binding site [nucleotide binding]; other site 650150005268 metal binding site B [ion binding]; metal-binding site 650150005269 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 650150005270 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 650150005271 Part of AAA domain; Region: AAA_19; pfam13245 650150005272 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 650150005273 Family description; Region: UvrD_C_2; pfam13538 650150005274 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 650150005275 nudix motif; other site 650150005276 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 650150005277 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 650150005278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 650150005279 active site 650150005280 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 650150005281 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 650150005282 Substrate binding site; other site 650150005283 Mg++ binding site; other site 650150005284 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 650150005285 active site 650150005286 substrate binding site [chemical binding]; other site 650150005287 CoA binding site [chemical binding]; other site 650150005288 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 650150005289 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 650150005290 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150005291 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 650150005292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150005293 S-adenosylmethionine binding site [chemical binding]; other site 650150005294 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 650150005295 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 650150005296 putative active site [active] 650150005297 putative metal binding site [ion binding]; other site 650150005298 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 650150005299 3D domain; Region: 3D; cl01439 650150005300 QueT transporter; Region: QueT; pfam06177 650150005301 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 650150005302 NAD(P) binding site [chemical binding]; other site 650150005303 catalytic residues [active] 650150005304 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 650150005305 amidohydrolase; Region: amidohydrolases; TIGR01891 650150005306 metal binding site [ion binding]; metal-binding site 650150005307 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 650150005308 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 650150005309 Walker A/P-loop; other site 650150005310 ATP binding site [chemical binding]; other site 650150005311 Q-loop/lid; other site 650150005312 ABC transporter signature motif; other site 650150005313 Walker B; other site 650150005314 D-loop; other site 650150005315 H-loop/switch region; other site 650150005316 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 650150005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 650150005318 dimer interface [polypeptide binding]; other site 650150005319 conserved gate region; other site 650150005320 ABC-ATPase subunit interface; other site 650150005321 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 650150005322 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 650150005323 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 650150005324 active site 650150005325 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 650150005326 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 650150005327 trmE is a tRNA modification GTPase; Region: trmE; cd04164 650150005328 G1 box; other site 650150005329 GTP/Mg2+ binding site [chemical binding]; other site 650150005330 Switch I region; other site 650150005331 G2 box; other site 650150005332 Switch II region; other site 650150005333 G3 box; other site 650150005334 G4 box; other site 650150005335 G5 box; other site 650150005336 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 650150005337 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 650150005338 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 650150005339 active site 650150005340 ParB-like nuclease domain; Region: ParB; smart00470 650150005341 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 650150005342 KorB domain; Region: KorB; pfam08535 650150005343 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 650150005344 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 650150005345 P-loop; other site 650150005346 Magnesium ion binding site [ion binding]; other site 650150005347 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 650150005348 ParB-like nuclease domain; Region: ParBc; pfam02195 650150005349 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 650150005350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 650150005351 S-adenosylmethionine binding site [chemical binding]; other site 650150005352 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 650150005353 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 650150005354 G1 box; other site 650150005355 putative GEF interaction site [polypeptide binding]; other site 650150005356 GTP/Mg2+ binding site [chemical binding]; other site 650150005357 Switch I region; other site 650150005358 G2 box; other site 650150005359 G3 box; other site 650150005360 Switch II region; other site 650150005361 G4 box; other site 650150005362 G5 box; other site 650150005363 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 650150005364 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 650150005365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 650150005366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 650150005367 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 650150005368 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 650150005369 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 650150005370 Predicted transcriptional regulators [Transcription]; Region: COG1725 650150005371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150005372 DNA-binding site [nucleotide binding]; DNA binding site 650150005373 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150005374 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 650150005375 Walker A/P-loop; other site 650150005376 ATP binding site [chemical binding]; other site 650150005377 Q-loop/lid; other site 650150005378 ABC transporter signature motif; other site 650150005379 Walker B; other site 650150005380 D-loop; other site 650150005381 H-loop/switch region; other site 650150005382 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 650150005383 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 650150005384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150005385 catalytic core [active] 650150005386 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 650150005387 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 650150005388 active site 650150005389 HIGH motif; other site 650150005390 KMSKS motif; other site 650150005391 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 650150005392 tRNA binding surface [nucleotide binding]; other site 650150005393 anticodon binding site; other site 650150005394 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 650150005395 dimer interface [polypeptide binding]; other site 650150005396 putative tRNA-binding site [nucleotide binding]; other site 650150005397 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 650150005398 metal ion-dependent adhesion site (MIDAS); other site 650150005399 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005400 domain interaction interfaces [polypeptide binding]; other site 650150005401 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005402 domain interaction interfaces [polypeptide binding]; other site 650150005403 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005404 domain interaction interfaces [polypeptide binding]; other site 650150005405 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005406 domain interaction interfaces [polypeptide binding]; other site 650150005407 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005408 domain interaction interfaces [polypeptide binding]; other site 650150005409 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 650150005410 domain interaction interfaces [polypeptide binding]; other site 650150005411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150005412 non-specific DNA binding site [nucleotide binding]; other site 650150005413 salt bridge; other site 650150005414 sequence-specific DNA binding site [nucleotide binding]; other site 650150005415 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 650150005416 metal binding site 2 [ion binding]; metal-binding site 650150005417 putative DNA binding helix; other site 650150005418 metal binding site 1 [ion binding]; metal-binding site 650150005419 dimer interface [polypeptide binding]; other site 650150005420 structural Zn2+ binding site [ion binding]; other site 650150005421 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 650150005422 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 650150005423 active site 650150005424 Predicted methyltransferases [General function prediction only]; Region: COG0313 650150005425 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 650150005426 putative SAM binding site [chemical binding]; other site 650150005427 putative homodimer interface [polypeptide binding]; other site 650150005428 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 650150005429 DNA polymerase III subunit delta'; Validated; Region: PRK08485 650150005430 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 650150005431 thymidylate kinase; Validated; Region: tmk; PRK00698 650150005432 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 650150005433 TMP-binding site; other site 650150005434 ATP-binding site [chemical binding]; other site 650150005435 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 650150005436 dimer interface [polypeptide binding]; other site 650150005437 ADP-ribose binding site [chemical binding]; other site 650150005438 active site 650150005439 nudix motif; other site 650150005440 metal binding site [ion binding]; metal-binding site 650150005441 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 650150005442 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 650150005443 active site 650150005444 Septum formation initiator; Region: DivIC; cl17659 650150005445 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150005446 RNA binding surface [nucleotide binding]; other site 650150005447 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 650150005448 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 650150005449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150005450 ATP binding site [chemical binding]; other site 650150005451 putative Mg++ binding site [ion binding]; other site 650150005452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150005453 nucleotide binding region [chemical binding]; other site 650150005454 ATP-binding site [chemical binding]; other site 650150005455 TRCF domain; Region: TRCF; pfam03461 650150005456 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 650150005457 putative active site [active] 650150005458 catalytic residue [active] 650150005459 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 650150005460 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 650150005461 G-X-X-G motif; other site 650150005462 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 650150005463 RxxxH motif; other site 650150005464 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 650150005465 Ribonuclease P; Region: Ribonuclease_P; pfam00825 650150005466 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399