-- dump date 20111121_011951 -- class Genbank::misc_feature -- table misc_feature_note -- id note 650150000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 650150000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150000003 Walker A motif; other site 650150000004 ATP binding site [chemical binding]; other site 650150000005 Walker B motif; other site 650150000006 arginine finger; other site 650150000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 650150000008 DnaA box-binding interface [nucleotide binding]; other site 650150000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 650150000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 650150000011 putative DNA binding surface [nucleotide binding]; other site 650150000012 dimer interface [polypeptide binding]; other site 650150000013 beta-clamp/clamp loader binding surface; other site 650150000014 beta-clamp/translesion DNA polymerase binding surface; other site 650150000015 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 650150000016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000017 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 650150000018 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 650150000019 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 650150000020 putative substrate binding site [chemical binding]; other site 650150000021 putative ATP binding site [chemical binding]; other site 650150000022 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 650150000023 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000024 active site 650150000025 phosphorylation site [posttranslational modification] 650150000026 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 650150000027 P-loop; other site 650150000028 active site 650150000029 phosphorylation site [posttranslational modification] 650150000030 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150000031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 650150000032 recombination protein F; Reviewed; Region: recF; PRK00064 650150000033 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000034 Walker A/P-loop; other site 650150000035 ATP binding site [chemical binding]; other site 650150000036 Q-loop/lid; other site 650150000037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000038 ABC transporter signature motif; other site 650150000039 Walker B; other site 650150000040 D-loop; other site 650150000041 H-loop/switch region; other site 650150000042 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 650150000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000044 ATP binding site [chemical binding]; other site 650150000045 Mg2+ binding site [ion binding]; other site 650150000046 G-X-G motif; other site 650150000047 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 650150000048 anchoring element; other site 650150000049 dimer interface [polypeptide binding]; other site 650150000050 ATP binding site [chemical binding]; other site 650150000051 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 650150000052 active site 650150000053 putative metal-binding site [ion binding]; other site 650150000054 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 650150000055 DNA gyrase subunit A; Validated; Region: PRK05560 650150000056 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 650150000057 CAP-like domain; other site 650150000058 Active site [active] 650150000059 primary dimer interface [polypeptide binding]; other site 650150000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 650150000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 650150000068 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150000069 motif 1; other site 650150000070 dimer interface [polypeptide binding]; other site 650150000071 active site 650150000072 motif 2; other site 650150000073 motif 3; other site 650150000074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150000075 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150000076 active site 650150000077 motif I; other site 650150000078 motif II; other site 650150000079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150000080 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 650150000081 nucleoside/Zn binding site; other site 650150000082 dimer interface [polypeptide binding]; other site 650150000083 catalytic motif [active] 650150000084 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 650150000085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000086 Coenzyme A binding pocket [chemical binding]; other site 650150000087 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 650150000088 active site 650150000089 catalytic site [active] 650150000090 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 650150000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150000092 Walker A motif; other site 650150000093 ATP binding site [chemical binding]; other site 650150000094 Walker B motif; other site 650150000095 arginine finger; other site 650150000096 recombination protein RecR; Reviewed; Region: recR; PRK00076 650150000097 RecR protein; Region: RecR; pfam02132 650150000098 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 650150000099 putative active site [active] 650150000100 putative metal-binding site [ion binding]; other site 650150000101 tetramer interface [polypeptide binding]; other site 650150000102 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 650150000103 putative active site [active] 650150000104 putative metal binding residues [ion binding]; other site 650150000105 signature motif; other site 650150000106 putative triphosphate binding site [ion binding]; other site 650150000107 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 650150000108 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 650150000109 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150000110 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000111 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 650150000112 MutS domain I; Region: MutS_I; pfam01624 650150000113 MutS family domain IV; Region: MutS_IV; pfam05190 650150000114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000115 Walker A/P-loop; other site 650150000116 ATP binding site [chemical binding]; other site 650150000117 Q-loop/lid; other site 650150000118 ABC transporter signature motif; other site 650150000119 Walker B; other site 650150000120 D-loop; other site 650150000121 H-loop/switch region; other site 650150000122 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 650150000123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000124 ATP binding site [chemical binding]; other site 650150000125 Mg2+ binding site [ion binding]; other site 650150000126 G-X-G motif; other site 650150000127 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 650150000128 ATP binding site [chemical binding]; other site 650150000129 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 650150000130 IPP transferase; Region: IPPT; cl00403 650150000131 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150000132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000133 Walker A/P-loop; other site 650150000134 ATP binding site [chemical binding]; other site 650150000135 Q-loop/lid; other site 650150000136 ABC transporter signature motif; other site 650150000137 Walker B; other site 650150000138 D-loop; other site 650150000139 H-loop/switch region; other site 650150000140 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 650150000141 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150000142 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150000143 Walker A/P-loop; other site 650150000144 ATP binding site [chemical binding]; other site 650150000145 Q-loop/lid; other site 650150000146 ABC transporter signature motif; other site 650150000147 Walker B; other site 650150000148 D-loop; other site 650150000149 H-loop/switch region; other site 650150000150 FtsX-like permease family; Region: FtsX; pfam02687 650150000151 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 650150000152 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 650150000153 hypothetical protein; Provisional; Region: PRK11568 650150000154 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 650150000155 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 650150000156 metal binding site 2 [ion binding]; metal-binding site 650150000157 putative DNA binding helix; other site 650150000158 metal binding site 1 [ion binding]; metal-binding site 650150000159 dimer interface [polypeptide binding]; other site 650150000160 structural Zn2+ binding site [ion binding]; other site 650150000161 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 650150000162 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 650150000163 putative metal binding site [ion binding]; other site 650150000164 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 650150000165 active site 650150000166 metal binding site [ion binding]; metal-binding site 650150000167 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 650150000168 Cation efflux family; Region: Cation_efflux; cl00316 650150000169 H+ Antiporter protein; Region: 2A0121; TIGR00900 650150000170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000171 putative substrate translocation pore; other site 650150000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000173 non-specific DNA binding site [nucleotide binding]; other site 650150000174 salt bridge; other site 650150000175 sequence-specific DNA binding site [nucleotide binding]; other site 650150000176 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150000177 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 650150000178 active site 650150000179 dimer interface [polypeptide binding]; other site 650150000180 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150000181 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150000182 putative transposase OrfB; Reviewed; Region: PHA02517 650150000183 Integrase core domain; Region: rve; cl01316 650150000184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150000185 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 650150000186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000187 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 650150000188 FeoA domain; Region: FeoA; cl00838 650150000189 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 650150000190 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 650150000191 metal binding site [ion binding]; metal-binding site 650150000192 intersubunit interface [polypeptide binding]; other site 650150000193 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 650150000194 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 650150000195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 650150000196 ABC-ATPase subunit interface; other site 650150000197 dimer interface [polypeptide binding]; other site 650150000198 putative PBP binding regions; other site 650150000199 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 650150000200 ABC-ATPase subunit interface; other site 650150000201 dimer interface [polypeptide binding]; other site 650150000202 putative PBP binding regions; other site 650150000203 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 650150000204 active site 650150000205 Beta-lactamase; Region: Beta-lactamase; cl01009 650150000206 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 650150000207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150000208 G5 domain; Region: G5; pfam07501 650150000209 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 650150000210 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 650150000211 nucleotide binding site [chemical binding]; other site 650150000212 homotetrameric interface [polypeptide binding]; other site 650150000213 putative phosphate binding site [ion binding]; other site 650150000214 putative allosteric binding site; other site 650150000215 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 650150000216 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 650150000217 putative catalytic cysteine [active] 650150000218 Sulfatase; Region: Sulfatase; cl10460 650150000219 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 650150000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150000221 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 650150000222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150000223 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 650150000224 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 650150000225 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 650150000226 synthetase active site [active] 650150000227 NTP binding site [chemical binding]; other site 650150000228 metal binding site [ion binding]; metal-binding site 650150000229 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 650150000230 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 650150000231 Uncharacterized conserved protein [Function unknown]; Region: COG1284 650150000232 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150000233 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150000234 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 650150000235 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 650150000236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150000237 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 650150000238 active site 650150000239 dimer interface [polypeptide binding]; other site 650150000240 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 650150000241 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 650150000242 active site 650150000243 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150000244 dimer interface [polypeptide binding]; other site 650150000245 substrate binding site [chemical binding]; other site 650150000246 catalytic residues [active] 650150000247 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 650150000248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150000249 motif II; other site 650150000250 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 650150000251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150000252 RmuC family; Region: RmuC; pfam02646 650150000253 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 650150000254 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 650150000255 active site 650150000256 nucleophile elbow; other site 650150000257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 650150000258 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 650150000259 active site 650150000260 catalytic tetrad [active] 650150000261 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 650150000262 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150000263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150000264 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150000265 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150000266 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000267 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000268 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000269 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150000270 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000271 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000272 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000273 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000274 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000275 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150000276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000277 Coenzyme A binding pocket [chemical binding]; other site 650150000278 Sulfate transporter family; Region: Sulfate_transp; cl00967 650150000279 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 650150000280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 650150000281 minor groove reading motif; other site 650150000282 helix-hairpin-helix signature motif; other site 650150000283 substrate binding pocket [chemical binding]; other site 650150000284 active site 650150000285 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 650150000286 DNA binding and oxoG recognition site [nucleotide binding] 650150000287 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 650150000288 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 650150000289 Zn binding site [ion binding]; other site 650150000290 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 650150000291 Zn binding site [ion binding]; other site 650150000292 Transcriptional regulators [Transcription]; Region: MarR; COG1846 650150000293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000294 Predicted esterase [General function prediction only]; Region: COG0400 650150000295 Flavin Reductases; Region: FlaRed; cl00801 650150000296 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 650150000297 homodimer interface [polypeptide binding]; other site 650150000298 NAD binding site [chemical binding]; other site 650150000299 catalytic residues [active] 650150000300 substrate binding pocket [chemical binding]; other site 650150000301 flexible flap; other site 650150000302 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 650150000303 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 650150000304 NAD binding site [chemical binding]; other site 650150000305 dimer interface [polypeptide binding]; other site 650150000306 substrate binding site [chemical binding]; other site 650150000307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150000308 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 650150000309 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 650150000310 G1 box; other site 650150000311 putative GEF interaction site [polypeptide binding]; other site 650150000312 GTP/Mg2+ binding site [chemical binding]; other site 650150000313 Switch I region; other site 650150000314 G2 box; other site 650150000315 G3 box; other site 650150000316 Switch II region; other site 650150000317 G4 box; other site 650150000318 G5 box; other site 650150000319 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 650150000320 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to...; Region: Elongation_Factor_C; cl02785 650150000321 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 650150000322 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 650150000323 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 650150000324 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 650150000325 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 650150000326 NAD synthetase; Provisional; Region: PRK13981 650150000327 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 650150000328 multimer interface [polypeptide binding]; other site 650150000329 active site 650150000330 catalytic triad [active] 650150000331 protein interface 1 [polypeptide binding]; other site 650150000332 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 650150000333 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150000334 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000335 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000336 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150000337 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150000338 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150000339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000340 Walker A/P-loop; other site 650150000341 ATP binding site [chemical binding]; other site 650150000342 Q-loop/lid; other site 650150000343 ABC transporter signature motif; other site 650150000344 Walker B; other site 650150000345 D-loop; other site 650150000346 H-loop/switch region; other site 650150000347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000348 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150000349 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 650150000350 Walker A/P-loop; other site 650150000351 ATP binding site [chemical binding]; other site 650150000352 Q-loop/lid; other site 650150000353 ABC transporter signature motif; other site 650150000354 Walker B; other site 650150000355 D-loop; other site 650150000356 H-loop/switch region; other site 650150000357 NifU-like domain; Region: NifU; cl00484 650150000358 Divergent PAP2 family; Region: DUF212; cl00855 650150000359 general stress protein 13; Validated; Region: PRK08059 650150000360 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 650150000361 RNA binding site [nucleotide binding]; other site 650150000362 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 650150000363 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 650150000364 active site 650150000365 dimer interface [polypeptide binding]; other site 650150000366 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 650150000367 dimer interface [polypeptide binding]; other site 650150000368 active site 650150000369 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 650150000370 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 650150000371 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150000372 putative transposase OrfB; Reviewed; Region: PHA02517 650150000373 Integrase core domain; Region: rve; cl01316 650150000374 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 650150000375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 650150000376 FeS/SAM binding site; other site 650150000377 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 650150000378 ATP cone domain; Region: ATP-cone; pfam03477 650150000379 Class III ribonucleotide reductase; Region: RNR_III; cd01675 650150000380 effector binding site; other site 650150000381 active site 650150000382 Zn binding site [ion binding]; other site 650150000383 glycine loop; other site 650150000384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 650150000385 ribonuclease R; Region: RNase_R; TIGR02063 650150000386 RNB domain; Region: RNB; pfam00773 650150000387 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 650150000388 RNA binding site [nucleotide binding]; other site 650150000389 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 650150000390 SmpB-tmRNA interface; other site 650150000391 LemA family; Region: LemA; cl00742 650150000392 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 650150000393 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 650150000394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000395 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150000396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000397 Walker A/P-loop; other site 650150000398 ATP binding site [chemical binding]; other site 650150000399 Q-loop/lid; other site 650150000400 ABC transporter signature motif; other site 650150000401 Walker B; other site 650150000402 D-loop; other site 650150000403 H-loop/switch region; other site 650150000404 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150000405 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150000406 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 650150000407 Walker A/P-loop; other site 650150000408 ATP binding site [chemical binding]; other site 650150000409 Q-loop/lid; other site 650150000410 ABC transporter signature motif; other site 650150000411 Walker B; other site 650150000412 D-loop; other site 650150000413 H-loop/switch region; other site 650150000414 Uncharacterized conserved protein [Function unknown]; Region: COG1624 650150000415 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 650150000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 650150000417 YbbR-like protein; Region: YbbR; pfam07949 650150000418 YbbR-like protein; Region: YbbR; pfam07949 650150000419 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 650150000420 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 650150000421 active site 650150000422 substrate binding site [chemical binding]; other site 650150000423 metal binding site [ion binding]; metal-binding site 650150000424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000426 active site 650150000427 phosphorylation site [posttranslational modification] 650150000428 intermolecular recognition site; other site 650150000429 dimerization interface [polypeptide binding]; other site 650150000430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150000431 DNA binding site [nucleotide binding] 650150000432 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 650150000433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150000434 dimer interface [polypeptide binding]; other site 650150000435 phosphorylation site [posttranslational modification] 650150000436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000437 ATP binding site [chemical binding]; other site 650150000438 Mg2+ binding site [ion binding]; other site 650150000439 G-X-G motif; other site 650150000440 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 650150000441 putative metal binding site [ion binding]; other site 650150000442 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 650150000443 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 650150000444 active site 650150000445 dimer interface [polypeptide binding]; other site 650150000446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150000447 Coenzyme A binding pocket [chemical binding]; other site 650150000448 Predicted membrane protein [Function unknown]; Region: COG4684 650150000449 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 650150000450 Flavoprotein; Region: Flavoprotein; cl08021 650150000451 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 650150000452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000454 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150000455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150000456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 650150000457 active site 650150000458 Family of unknown function (DUF695); Region: DUF695; pfam05117 650150000459 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 650150000460 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 650150000461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000462 active site 650150000463 phosphorylation site [posttranslational modification] 650150000464 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 650150000465 P-loop; other site 650150000466 active site 650150000467 phosphorylation site [posttranslational modification] 650150000468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000470 PRD domain; Region: PRD; pfam00874 650150000471 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 650150000472 P-loop; other site 650150000473 active site 650150000474 phosphorylation site [posttranslational modification] 650150000475 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150000476 active site 650150000477 phosphorylation site [posttranslational modification] 650150000478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000479 putative substrate translocation pore; other site 650150000480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 650150000481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150000482 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 650150000483 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 650150000484 TraB family; Region: TraB; cl12050 650150000485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 650150000486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000487 non-specific DNA binding site [nucleotide binding]; other site 650150000488 salt bridge; other site 650150000489 sequence-specific DNA binding site [nucleotide binding]; other site 650150000490 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 650150000491 23S rRNA interface [nucleotide binding]; other site 650150000492 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 650150000493 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 650150000494 core dimer interface [polypeptide binding]; other site 650150000495 peripheral dimer interface [polypeptide binding]; other site 650150000496 L10 interface [polypeptide binding]; other site 650150000497 L11 interface [polypeptide binding]; other site 650150000498 putative EF-Tu interaction site [polypeptide binding]; other site 650150000499 putative EF-G interaction site [polypeptide binding]; other site 650150000500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150000501 S-adenosylmethionine binding site [chemical binding]; other site 650150000502 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 650150000503 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 650150000504 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 650150000505 RPB1 interaction site [polypeptide binding]; other site 650150000506 RPB10 interaction site [polypeptide binding]; other site 650150000507 RPB11 interaction site [polypeptide binding]; other site 650150000508 RPB3 interaction site [polypeptide binding]; other site 650150000509 RPB12 interaction site [polypeptide binding]; other site 650150000510 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 650150000511 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 650150000512 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 650150000513 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 650150000514 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 650150000515 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 650150000516 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 650150000517 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 650150000518 DNA binding site [nucleotide binding] 650150000519 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 650150000520 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 650150000521 active site 650150000522 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 650150000523 active site 650150000524 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150000525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150000526 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 650150000527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000528 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 650150000529 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 650150000530 substrate binding site [chemical binding]; other site 650150000531 catalytic residues [active] 650150000532 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 650150000533 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 650150000534 dimer interface [polypeptide binding]; other site 650150000535 FMN binding site [chemical binding]; other site 650150000536 NADPH bind site [chemical binding]; other site 650150000537 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 650150000538 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 650150000539 catalytic residues [active] 650150000540 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 650150000541 MatE; Region: MatE; pfam01554 650150000542 MatE; Region: MatE; pfam01554 650150000543 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 650150000544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150000545 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 650150000546 putative ADP-binding pocket [chemical binding]; other site 650150000547 Chromate transporter; Region: Chromate_transp; pfam02417 650150000548 Chromate transporter; Region: Chromate_transp; pfam02417 650150000549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150000550 non-specific DNA binding site [nucleotide binding]; other site 650150000551 salt bridge; other site 650150000552 sequence-specific DNA binding site [nucleotide binding]; other site 650150000553 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 650150000554 active site 650150000555 Zn-binding site [ion binding]; other site 650150000556 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 650150000557 dimer interface [polypeptide binding]; other site 650150000558 catalytic triad [active] 650150000559 peroxidatic and resolving cysteines [active] 650150000560 TRAM domain; Region: TRAM; cl01282 650150000561 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 650150000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150000563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150000564 S-adenosylmethionine binding site [chemical binding]; other site 650150000565 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 650150000566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150000567 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150000568 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 650150000569 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 650150000570 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 650150000571 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 650150000572 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 650150000573 putative active site [active] 650150000574 catalytic site [active] 650150000575 putative metal binding site [ion binding]; other site 650150000576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000577 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150000578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150000579 Integrase core domain; Region: rve; cl01316 650150000580 LytTr DNA-binding domain; Region: LytTR; cl04498 650150000581 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 650150000582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000584 peroxiredoxin; Provisional; Region: PRK13189 650150000585 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 650150000586 dimer interface [polypeptide binding]; other site 650150000587 decamer (pentamer of dimers) interface [polypeptide binding]; other site 650150000588 catalytic triad [active] 650150000589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150000590 S-adenosylmethionine binding site [chemical binding]; other site 650150000591 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 650150000592 Restriction endonuclease; Region: Mrr_cat; cl00747 650150000593 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 650150000594 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 650150000595 HIGH motif; other site 650150000596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150000597 active site 650150000598 KMSKS motif; other site 650150000599 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 650150000600 tRNA binding surface [nucleotide binding]; other site 650150000601 SAF domain; Region: SAF; cl00555 650150000602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000603 Walker A motif; other site 650150000604 ATP binding site [chemical binding]; other site 650150000605 Walker B motif; other site 650150000606 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 650150000607 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 650150000608 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 650150000609 putative active site [active] 650150000610 putative metal binding site [ion binding]; other site 650150000611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000612 Low molecular weight phosphatase family; Region: LMWPc; cd00115 650150000613 Active site [active] 650150000614 LrgB-like family; Region: LrgB; cl00596 650150000615 LrgA family; Region: LrgA; cl00608 650150000616 glycerol kinase; Provisional; Region: glpK; PRK00047 650150000617 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150000618 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 650150000619 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 650150000620 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 650150000621 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 650150000622 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 650150000623 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 650150000624 Walker A/P-loop; other site 650150000625 ATP binding site [chemical binding]; other site 650150000626 Q-loop/lid; other site 650150000627 ABC transporter signature motif; other site 650150000628 Walker B; other site 650150000629 D-loop; other site 650150000630 H-loop/switch region; other site 650150000631 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150000632 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150000633 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150000634 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 650150000635 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 650150000636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000637 Walker A/P-loop; other site 650150000638 ATP binding site [chemical binding]; other site 650150000639 Q-loop/lid; other site 650150000640 ABC transporter signature motif; other site 650150000641 Walker B; other site 650150000642 D-loop; other site 650150000643 H-loop/switch region; other site 650150000644 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 650150000645 ABC-2 type transporter; Region: ABC2_membrane; cl11417 650150000646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150000647 aspartate dehydrogenase; Region: NAD_NadX; TIGR03855 650150000648 Domain of unknown function DUF108; Region: DUF108; pfam01958 650150000649 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 650150000650 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 650150000651 AMP-binding enzyme; Region: AMP-binding; pfam00501 650150000652 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 650150000653 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 650150000654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 650150000655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150000656 catalytic residue [active] 650150000657 MBOAT family; Region: MBOAT; cl00738 650150000658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000660 active site 650150000661 phosphorylation site [posttranslational modification] 650150000662 intermolecular recognition site; other site 650150000663 dimerization interface [polypeptide binding]; other site 650150000664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150000665 DNA binding site [nucleotide binding] 650150000666 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 650150000667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150000668 dimer interface [polypeptide binding]; other site 650150000669 phosphorylation site [posttranslational modification] 650150000670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 650150000671 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 650150000672 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 650150000673 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 650150000674 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 650150000675 active site 650150000676 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150000677 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150000678 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150000679 PhoU domain; Region: PhoU; pfam01895 650150000680 PhoU domain; Region: PhoU; pfam01895 650150000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150000682 S-adenosylmethionine binding site [chemical binding]; other site 650150000683 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 650150000684 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000685 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150000686 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150000687 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 650150000688 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 650150000689 active site 650150000690 catalytic residues [active] 650150000691 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000692 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150000693 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 650150000694 active site turn [active] 650150000695 phosphorylation site [posttranslational modification] 650150000696 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 650150000697 active site 650150000698 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948 650150000699 active site 650150000700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150000701 dimer interface [polypeptide binding]; other site 650150000702 conserved gate region; other site 650150000703 ABC-ATPase subunit interface; other site 650150000704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 650150000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150000706 dimer interface [polypeptide binding]; other site 650150000707 conserved gate region; other site 650150000708 putative PBP binding loops; other site 650150000709 ABC-ATPase subunit interface; other site 650150000710 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150000711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150000712 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 650150000713 Protein of unknown function, DUF624; Region: DUF624; cl02369 650150000714 Histidine kinase; Region: His_kinase; pfam06580 650150000715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 650150000716 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 650150000717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000718 active site 650150000719 phosphorylation site [posttranslational modification] 650150000720 intermolecular recognition site; other site 650150000721 dimerization interface [polypeptide binding]; other site 650150000722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000724 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 650150000725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150000726 putative substrate translocation pore; other site 650150000727 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 650150000728 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 650150000729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150000730 DNA-binding site [nucleotide binding]; DNA binding site 650150000731 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150000732 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 650150000733 ligand binding site [chemical binding]; other site 650150000734 dimerization interface [polypeptide binding]; other site 650150000735 Uncharacterized conserved protein [Function unknown]; Region: COG3538 650150000736 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 650150000737 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 650150000738 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 650150000739 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 650150000740 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 650150000741 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 650150000742 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000743 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150000744 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150000745 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150000746 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150000747 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 650150000748 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 650150000749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150000750 catalytic core [active] 650150000751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150000752 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 650150000753 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150000754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150000755 putative transposase OrfB; Reviewed; Region: PHA02517 650150000756 Integrase core domain; Region: rve; cl01316 650150000757 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 650150000758 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 650150000759 Double zinc ribbon; Region: DZR; pfam12773 650150000760 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 650150000761 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150000762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150000763 Integrase core domain; Region: rve; cl01316 650150000764 methionine aminopeptidase; Reviewed; Region: PRK07281 650150000765 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 650150000766 active site 650150000767 transcriptional antiterminator BglG; Provisional; Region: PRK09772 650150000768 PRD domain; Region: PRD; pfam00874 650150000769 PRD domain; Region: PRD; pfam00874 650150000770 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 650150000771 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 650150000772 putative active site cavity [active] 650150000773 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 650150000774 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150000775 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 650150000776 active site turn [active] 650150000777 phosphorylation site [posttranslational modification] 650150000778 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 650150000779 HPr interaction site; other site 650150000780 glycerol kinase (GK) interaction site [polypeptide binding]; other site 650150000781 active site 650150000782 phosphorylation site [posttranslational modification] 650150000783 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 650150000784 putative catalytic site [active] 650150000785 putative metal binding site [ion binding]; other site 650150000786 putative phosphate binding site [ion binding]; other site 650150000787 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 650150000788 DNA-binding site [nucleotide binding]; DNA binding site 650150000789 RNA-binding motif; other site 650150000790 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 650150000791 putative active site [active] 650150000792 catalytic triad [active] 650150000793 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 650150000794 Bacitracin resistance protein BacA; Region: BacA; cl00858 650150000795 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 650150000796 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 650150000797 folate binding site [chemical binding]; other site 650150000798 NADP+ binding site [chemical binding]; other site 650150000799 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 650150000800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150000801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150000802 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 650150000803 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150000804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000805 active site 650150000806 phosphorylation site [posttranslational modification] 650150000807 intermolecular recognition site; other site 650150000808 dimerization interface [polypeptide binding]; other site 650150000809 LytTr DNA-binding domain; Region: LytTR; cl04498 650150000810 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 650150000811 Accessory gene regulator B; Region: AgrB; cl01873 650150000812 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150000813 putative transposase OrfB; Reviewed; Region: PHA02517 650150000814 Integrase core domain; Region: rve; cl01316 650150000815 Sulfate transporter family; Region: Sulfate_transp; cl00967 650150000816 Permease family; Region: Xan_ur_permease; pfam00860 650150000817 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 650150000818 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 650150000819 Integrase core domain; Region: rve; cl01316 650150000820 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 650150000821 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 650150000822 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 650150000823 active site 650150000824 phosphorylation site [posttranslational modification] 650150000825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150000827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150000828 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 650150000829 active pocket/dimerization site; other site 650150000830 active site 650150000831 phosphorylation site [posttranslational modification] 650150000832 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 650150000833 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150000834 dimer interface [polypeptide binding]; other site 650150000835 active site 650150000836 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 650150000837 Domain of unknown function DUF77; Region: DUF77; cl00307 650150000838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150000839 dimer interface [polypeptide binding]; other site 650150000840 conserved gate region; other site 650150000841 putative PBP binding loops; other site 650150000842 ABC-ATPase subunit interface; other site 650150000843 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150000844 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 650150000845 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 650150000846 Walker A/P-loop; other site 650150000847 ATP binding site [chemical binding]; other site 650150000848 Q-loop/lid; other site 650150000849 ABC transporter signature motif; other site 650150000850 Walker B; other site 650150000851 D-loop; other site 650150000852 H-loop/switch region; other site 650150000853 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 650150000854 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 650150000855 G1 box; other site 650150000856 GTP/Mg2+ binding site [chemical binding]; other site 650150000857 Switch I region; other site 650150000858 G2 box; other site 650150000859 G3 box; other site 650150000860 Switch II region; other site 650150000861 G4 box; other site 650150000862 G5 box; other site 650150000863 ATP-dependent RNA helicase, pseudogene, truncated by frameshift mutation 650150000864 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 650150000865 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 650150000866 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 650150000867 catalytic site [active] 650150000868 Asp-box motif; other site 650150000869 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 650150000870 Asp-box motif; other site 650150000871 catalytic site [active] 650150000872 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 650150000873 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 650150000874 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 650150000875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 650150000876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150000877 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150000878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 650150000879 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 650150000880 probable active site [active] 650150000881 putative inner membrane protein; Provisional; Region: PRK11099 650150000882 YeeE/YedE family (DUF395); Region: DUF395; cl01018 650150000883 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 650150000884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150000885 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 650150000887 active site residue [active] 650150000888 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 650150000889 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 650150000890 integral membrane protein MviN; Region: mviN; TIGR01695 650150000891 MatE; Region: MatE; pfam01554 650150000892 SelR domain; Region: SelR; cl00369 650150000893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000895 active site 650150000896 phosphorylation site [posttranslational modification] 650150000897 intermolecular recognition site; other site 650150000898 dimerization interface [polypeptide binding]; other site 650150000899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150000900 DNA binding site [nucleotide binding] 650150000901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150000902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150000903 dimer interface [polypeptide binding]; other site 650150000904 phosphorylation site [posttranslational modification] 650150000905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150000906 ATP binding site [chemical binding]; other site 650150000907 Mg2+ binding site [ion binding]; other site 650150000908 G-X-G motif; other site 650150000909 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150000910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150000911 active site 650150000912 phosphorylation site [posttranslational modification] 650150000913 intermolecular recognition site; other site 650150000914 dimerization interface [polypeptide binding]; other site 650150000915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150000916 DNA binding site [nucleotide binding] 650150000917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150000918 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 650150000919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150000920 dimer interface [polypeptide binding]; other site 650150000921 phosphorylation site [posttranslational modification] 650150000922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 650150000923 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 650150000924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150000925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150000926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150000927 dimerization interface [polypeptide binding]; other site 650150000928 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150000929 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 650150000930 putative active site [active] 650150000931 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150000932 Domain of unknown function (DU1801); Region: DUF1801; cl01838 650150000933 Predicted transcriptional regulators [Transcription]; Region: COG1725 650150000934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150000935 DNA-binding site [nucleotide binding]; DNA binding site 650150000936 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150000937 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 650150000938 Walker A/P-loop; other site 650150000939 ATP binding site [chemical binding]; other site 650150000940 Q-loop/lid; other site 650150000941 ABC transporter signature motif; other site 650150000942 Walker B; other site 650150000943 D-loop; other site 650150000944 H-loop/switch region; other site 650150000945 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 650150000946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150000947 Walker A/P-loop; other site 650150000948 ATP binding site [chemical binding]; other site 650150000949 Q-loop/lid; other site 650150000950 ABC transporter signature motif; other site 650150000951 Walker B; other site 650150000952 D-loop; other site 650150000953 H-loop/switch region; other site 650150000954 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150000955 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 650150000956 active site 650150000957 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 650150000958 DNA-binding site [nucleotide binding]; DNA binding site 650150000959 RNA-binding motif; other site 650150000960 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 650150000961 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150000962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150000963 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 650150000964 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 650150000965 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 650150000966 putative active site [active] 650150000967 catalytic site [active] 650150000968 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 650150000969 putative active site [active] 650150000970 catalytic site [active] 650150000971 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 650150000972 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 650150000973 active site 650150000974 nucleophile elbow; other site 650150000975 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 650150000976 active site 650150000977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150000978 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 650150000979 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150000980 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150000981 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 650150000982 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 650150000983 nucleotide binding pocket [chemical binding]; other site 650150000984 K-X-D-G motif; other site 650150000985 catalytic site [active] 650150000986 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 650150000987 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 650150000988 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 650150000989 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 650150000990 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 650150000991 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 650150000992 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 650150000993 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 650150000994 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 650150000995 GatB domain; Region: GatB_Yqey; cl11497 650150000996 O-Antigen ligase; Region: Wzy_C; cl04850 650150000997 oligoendopeptidase F; Region: pepF; TIGR00181 650150000998 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 650150000999 active site 650150001000 Zn binding site [ion binding]; other site 650150001001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001002 Predicted esterase [General function prediction only]; Region: COG0400 650150001003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150001004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001006 PRD domain; Region: PRD; pfam00874 650150001007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 650150001008 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 650150001009 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 650150001010 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 650150001011 active site 650150001012 phosphorylation site [posttranslational modification] 650150001013 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150001014 dimer interface [polypeptide binding]; other site 650150001015 active site 650150001016 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 650150001017 dimer interface [polypeptide binding]; other site 650150001018 active site 650150001019 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 650150001020 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 650150001021 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 650150001022 Class I ribonucleotide reductase; Region: RNR_I; cd01679 650150001023 active site 650150001024 dimer interface [polypeptide binding]; other site 650150001025 catalytic residues [active] 650150001026 effector binding site; other site 650150001027 R2 peptide binding site; other site 650150001028 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 650150001029 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 650150001030 dimer interface [polypeptide binding]; other site 650150001031 putative radical transfer pathway; other site 650150001032 diiron center [ion binding]; other site 650150001033 tyrosyl radical; other site 650150001034 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 650150001035 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 650150001036 Mechanosensitive ion channel; Region: MS_channel; pfam00924 650150001037 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 650150001038 putative deacylase active site [active] 650150001039 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 650150001040 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 650150001041 Potassium binding sites [ion binding]; other site 650150001042 Cesium cation binding sites [ion binding]; other site 650150001043 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 650150001044 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 650150001045 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 650150001046 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 650150001047 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 650150001048 RNA binding site [nucleotide binding]; other site 650150001049 ATP synthase A chain; Region: ATP-synt_A; cl00413 650150001050 ATP synthase subunit C; Region: ATP-synt_C; cl00466 650150001051 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 650150001052 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 650150001053 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 650150001054 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150001055 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 650150001056 beta subunit interaction interface [polypeptide binding]; other site 650150001057 Walker A motif; other site 650150001058 ATP binding site [chemical binding]; other site 650150001059 Walker B motif; other site 650150001060 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150001061 ATP synthase; Region: ATP-synt; cl00365 650150001062 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 650150001063 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150001064 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 650150001065 alpha subunit interaction interface [polypeptide binding]; other site 650150001066 Walker A motif; other site 650150001067 ATP binding site [chemical binding]; other site 650150001068 Walker B motif; other site 650150001069 inhibitor binding site; inhibition site 650150001070 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150001071 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 650150001072 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 650150001073 Cation transport protein; Region: TrkH; cl10514 650150001074 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 650150001075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001076 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150001077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 650150001078 catalytic residues [active] 650150001079 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 650150001080 active site residue [active] 650150001081 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 650150001082 putative homotetramer interface [polypeptide binding]; other site 650150001083 putative homodimer interface [polypeptide binding]; other site 650150001084 putative metal binding site [ion binding]; other site 650150001085 putative homodimer-homodimer interface [polypeptide binding]; other site 650150001086 putative allosteric switch controlling residues; other site 650150001087 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150001089 Integrase core domain; Region: rve; cl01316 650150001090 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 650150001091 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 650150001092 putative active site pocket [active] 650150001093 dimerization interface [polypeptide binding]; other site 650150001094 putative catalytic residue [active] 650150001095 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 650150001096 putative substrate binding pocket [chemical binding]; other site 650150001097 AC domain interface; other site 650150001098 catalytic triad [active] 650150001099 AB domain interface; other site 650150001100 interchain disulfide; other site 650150001101 Protein of unknown function (DUF979); Region: DUF979; cl01572 650150001102 Protein of unknown function (DUF969); Region: DUF969; cl01573 650150001103 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 650150001104 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 650150001105 maltose O-acetyltransferase; Provisional; Region: PRK10092 650150001106 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 650150001107 active site 650150001108 substrate binding site [chemical binding]; other site 650150001109 trimer interface [polypeptide binding]; other site 650150001110 CoA binding site [chemical binding]; other site 650150001111 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 650150001112 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 650150001113 putative active site [active] 650150001114 catalytic site [active] 650150001115 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 650150001116 B3/4 domain; Region: B3_4; cl11458 650150001117 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 650150001118 LytTr DNA-binding domain; Region: LytTR; cl04498 650150001119 endonuclease IV; Provisional; Region: PRK01060 650150001120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 650150001121 AP (apurinic/apyrimidinic) site pocket; other site 650150001122 DNA interaction; other site 650150001123 Metal-binding active site; metal-binding site 650150001124 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 650150001125 proposed catalytic triad [active] 650150001126 conserved cys residue [active] 650150001127 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 650150001128 Pyruvate formate lyase 1; Region: PFL1; cd01678 650150001129 coenzyme A binding site [chemical binding]; other site 650150001130 active site 650150001131 catalytic residues [active] 650150001132 glycine loop; other site 650150001133 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 650150001134 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 650150001135 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 650150001136 NAD binding site [chemical binding]; other site 650150001137 sugar binding site [chemical binding]; other site 650150001138 divalent metal binding site [ion binding]; other site 650150001139 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150001140 dimer interface [polypeptide binding]; other site 650150001141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150001142 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150001143 active site 650150001144 motif I; other site 650150001145 motif II; other site 650150001146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150001147 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150001148 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 650150001149 putative active site [active] 650150001150 MBOAT family; Region: MBOAT; cl00738 650150001151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 650150001152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001153 catalytic residue [active] 650150001154 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150001155 active site 650150001156 metal binding site [ion binding]; metal-binding site 650150001157 Bacterial sugar transferase; Region: Bac_transf; cl00939 650150001158 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150001159 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 650150001160 Bacterial SH3 domain; Region: SH3_3; cl02551 650150001161 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150001162 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 650150001163 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 650150001164 active site 650150001165 Zn binding site [ion binding]; other site 650150001166 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 650150001167 zinc binding site [ion binding]; other site 650150001168 putative ligand binding site [chemical binding]; other site 650150001169 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 650150001170 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 650150001171 zinc binding site [ion binding]; other site 650150001172 putative ligand binding site [chemical binding]; other site 650150001173 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 650150001174 TM-ABC transporter signature motif; other site 650150001175 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 650150001176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001177 Walker A/P-loop; other site 650150001178 ATP binding site [chemical binding]; other site 650150001179 Q-loop/lid; other site 650150001180 ABC transporter signature motif; other site 650150001181 Walker B; other site 650150001182 D-loop; other site 650150001183 H-loop/switch region; other site 650150001184 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 650150001185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001186 Walker A/P-loop; other site 650150001187 ATP binding site [chemical binding]; other site 650150001188 Q-loop/lid; other site 650150001189 ABC transporter signature motif; other site 650150001190 Walker B; other site 650150001191 D-loop; other site 650150001192 H-loop/switch region; other site 650150001193 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 650150001194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150001195 dimer interface [polypeptide binding]; other site 650150001196 conserved gate region; other site 650150001197 putative PBP binding loops; other site 650150001198 ABC-ATPase subunit interface; other site 650150001199 ABC transporter, permease protein, pseudogene, truncated by premature stop codon 650150001200 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150001201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150001202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150001203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150001204 Predicted transcriptional regulator [Transcription]; Region: COG2378 650150001205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001206 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 650150001207 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 650150001208 Substrate-binding site [chemical binding]; other site 650150001209 Substrate specificity [chemical binding]; other site 650150001210 serine O-acetyltransferase; Region: cysE; TIGR01172 650150001211 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 650150001212 trimer interface [polypeptide binding]; other site 650150001213 active site 650150001214 substrate binding site [chemical binding]; other site 650150001215 CoA binding site [chemical binding]; other site 650150001216 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150001218 Integrase core domain; Region: rve; cl01316 650150001219 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 650150001220 adenylosuccinate synthetase; Provisional; Region: PRK01117 650150001221 GDP-binding site [chemical binding]; other site 650150001222 ACT binding site; other site 650150001223 IMP binding site; other site 650150001224 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 650150001225 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 650150001226 active site 650150001227 metal binding site [ion binding]; metal-binding site 650150001228 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 650150001229 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001230 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150001231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001232 Walker A/P-loop; other site 650150001233 ATP binding site [chemical binding]; other site 650150001234 Q-loop/lid; other site 650150001235 ABC transporter signature motif; other site 650150001236 Walker B; other site 650150001237 D-loop; other site 650150001238 H-loop/switch region; other site 650150001239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001240 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150001241 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 650150001242 Walker A/P-loop; other site 650150001243 ATP binding site [chemical binding]; other site 650150001244 Q-loop/lid; other site 650150001245 ABC transporter signature motif; other site 650150001246 Walker B; other site 650150001247 D-loop; other site 650150001248 H-loop/switch region; other site 650150001249 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150001250 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 650150001251 oligomer interface [polypeptide binding]; other site 650150001252 active site 650150001253 metal binding site [ion binding]; metal-binding site 650150001254 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 650150001255 hydrophobic ligand binding site; other site 650150001256 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 650150001257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150001258 DNA-binding site [nucleotide binding]; DNA binding site 650150001259 UTRA domain; Region: UTRA; cl06649 650150001260 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 650150001261 active site 650150001262 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 650150001263 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 650150001264 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 650150001265 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 650150001266 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 650150001267 active site 650150001268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001269 catalytic core [active] 650150001270 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 650150001271 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 650150001272 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 650150001273 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 650150001274 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 650150001275 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 650150001276 tetramer interface [polypeptide binding]; other site 650150001277 TPP-binding site [chemical binding]; other site 650150001278 heterodimer interface [polypeptide binding]; other site 650150001279 phosphorylation loop region [posttranslational modification] 650150001280 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 650150001281 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 650150001282 alpha subunit interface [polypeptide binding]; other site 650150001283 TPP binding site [chemical binding]; other site 650150001284 heterodimer interface [polypeptide binding]; other site 650150001285 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150001286 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 650150001287 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150001288 E3 interaction surface; other site 650150001289 lipoyl attachment site [posttranslational modification]; other site 650150001290 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150001291 E3 interaction surface; other site 650150001292 lipoyl attachment site [posttranslational modification]; other site 650150001293 e3 binding domain; Region: E3_binding; pfam02817 650150001294 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 650150001295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150001296 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 650150001297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150001298 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150001299 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 650150001300 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 650150001301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 650150001302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150001303 dimer interface [polypeptide binding]; other site 650150001304 conserved gate region; other site 650150001305 putative PBP binding loops; other site 650150001306 ABC-ATPase subunit interface; other site 650150001307 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 650150001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150001309 dimer interface [polypeptide binding]; other site 650150001310 conserved gate region; other site 650150001311 putative PBP binding loops; other site 650150001312 ABC-ATPase subunit interface; other site 650150001313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001314 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 650150001315 Walker A/P-loop; other site 650150001316 ATP binding site [chemical binding]; other site 650150001317 Q-loop/lid; other site 650150001318 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 650150001319 Q-loop/lid; other site 650150001320 ABC transporter signature motif; other site 650150001321 Walker B; other site 650150001322 D-loop; other site 650150001323 H-loop/switch region; other site 650150001324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 650150001325 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 650150001326 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 650150001327 Walker A/P-loop; other site 650150001328 ATP binding site [chemical binding]; other site 650150001329 Q-loop/lid; other site 650150001330 ABC transporter signature motif; other site 650150001331 Walker B; other site 650150001332 D-loop; other site 650150001333 H-loop/switch region; other site 650150001334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 650150001335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001337 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150001338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001339 Walker A/P-loop; other site 650150001340 ATP binding site [chemical binding]; other site 650150001341 Q-loop/lid; other site 650150001342 ABC transporter signature motif; other site 650150001343 Walker B; other site 650150001344 D-loop; other site 650150001345 H-loop/switch region; other site 650150001346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150001347 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150001348 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 650150001349 Walker A/P-loop; other site 650150001350 ATP binding site [chemical binding]; other site 650150001351 Q-loop/lid; other site 650150001352 ABC transporter signature motif; other site 650150001353 Walker B; other site 650150001354 D-loop; other site 650150001355 H-loop/switch region; other site 650150001356 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 650150001357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150001358 motif II; other site 650150001359 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 650150001360 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 650150001361 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 650150001362 DRTGG domain; Region: DRTGG; cl12147 650150001363 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 650150001364 DHH family; Region: DHH; pfam01368 650150001365 DHHA2 domain; Region: DHHA2; pfam02833 650150001366 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 650150001367 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 650150001368 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 650150001369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001370 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 650150001371 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 650150001372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001373 catalytic core [active] 650150001374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150001375 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 650150001376 dimer interface [polypeptide binding]; other site 650150001377 FMN binding site [chemical binding]; other site 650150001378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 650150001379 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 650150001380 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 650150001381 glutaminase active site [active] 650150001382 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 650150001383 dimer interface [polypeptide binding]; other site 650150001384 active site 650150001385 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 650150001386 dimer interface [polypeptide binding]; other site 650150001387 active site 650150001388 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001389 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150001390 Integrase core domain; Region: rve; cl01316 650150001391 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 650150001392 trimer interface [polypeptide binding]; other site 650150001393 active site 650150001394 G bulge; other site 650150001395 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 650150001396 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 650150001397 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 650150001398 active site 650150001399 NTP binding site [chemical binding]; other site 650150001400 metal binding triad [ion binding]; metal-binding site 650150001401 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 650150001402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150001403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150001404 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150001405 Walker A/P-loop; other site 650150001406 ATP binding site [chemical binding]; other site 650150001407 Q-loop/lid; other site 650150001408 ABC transporter signature motif; other site 650150001409 Walker B; other site 650150001410 D-loop; other site 650150001411 H-loop/switch region; other site 650150001412 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 650150001413 FtsX-like permease family; Region: FtsX; pfam02687 650150001414 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 650150001415 FtsX-like permease family; Region: FtsX; pfam02687 650150001416 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 650150001417 Domain of unknown function DUF21; Region: DUF21; pfam01595 650150001418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 650150001419 Transporter associated domain; Region: CorC_HlyC; pfam03471 650150001420 Rrf2 family protein; Region: rrf2_super; TIGR00738 650150001421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001422 cysteine synthases; Region: cysKM; TIGR01136 650150001423 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 650150001424 dimer interface [polypeptide binding]; other site 650150001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150001426 catalytic residue [active] 650150001427 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 650150001428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150001429 DNA-binding site [nucleotide binding]; DNA binding site 650150001430 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150001431 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 650150001432 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 650150001433 motif 1; other site 650150001434 active site 650150001435 motif 2; other site 650150001436 motif 3; other site 650150001437 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 650150001438 DHHA1 domain; Region: DHHA1; pfam02272 650150001439 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 650150001440 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 650150001441 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 650150001442 YceG-like family; Region: YceG; pfam02618 650150001443 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 650150001444 dimerization interface [polypeptide binding]; other site 650150001445 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 650150001446 Sugar specificity; other site 650150001447 Pyrimidine base specificity; other site 650150001448 ATP-binding site [chemical binding]; other site 650150001449 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 650150001450 domain; Region: GreA_GreB_N; pfam03449 650150001451 C-term; Region: GreA_GreB; pfam01272 650150001452 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 650150001453 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150001454 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 650150001455 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 650150001456 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 650150001457 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 650150001458 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 650150001459 putative active site [active] 650150001460 substrate binding site [chemical binding]; other site 650150001461 putative cosubstrate binding site; other site 650150001462 catalytic site [active] 650150001463 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 650150001464 substrate binding site [chemical binding]; other site 650150001465 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 650150001466 GTP-binding protein LepA; Provisional; Region: PRK05433 650150001467 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 650150001468 G1 box; other site 650150001469 putative GEF interaction site [polypeptide binding]; other site 650150001470 GTP/Mg2+ binding site [chemical binding]; other site 650150001471 Switch I region; other site 650150001472 G2 box; other site 650150001473 G3 box; other site 650150001474 Switch II region; other site 650150001475 G4 box; other site 650150001476 G5 box; other site 650150001477 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 650150001478 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 650150001479 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 650150001480 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 650150001481 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 650150001482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 650150001483 FeS/SAM binding site; other site 650150001484 HemN C-terminal region; Region: HemN_C; pfam06969 650150001485 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 650150001486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001487 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 650150001488 16S/18S rRNA binding site [nucleotide binding]; other site 650150001489 S13e-L30e interaction site [polypeptide binding]; other site 650150001490 25S rRNA binding site [nucleotide binding]; other site 650150001491 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 650150001492 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 650150001493 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 650150001494 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 650150001495 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 650150001496 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 650150001497 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 650150001498 putative nucleic acid binding region [nucleotide binding]; other site 650150001499 G-X-X-G motif; other site 650150001500 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 650150001501 RNA binding site [nucleotide binding]; other site 650150001502 domain interface; other site 650150001503 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 650150001504 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 650150001505 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 650150001506 HIT family signature motif; other site 650150001507 catalytic residue [active] 650150001508 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 650150001509 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 650150001510 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 650150001511 PPIC-type PPIASE domain; Region: Rotamase; cl08278 650150001512 FeS assembly ATPase SufC; Region: sufC; TIGR01978 650150001513 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 650150001514 Walker A/P-loop; other site 650150001515 ATP binding site [chemical binding]; other site 650150001516 Q-loop/lid; other site 650150001517 ABC transporter signature motif; other site 650150001518 Walker B; other site 650150001519 D-loop; other site 650150001520 H-loop/switch region; other site 650150001521 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 650150001522 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 650150001523 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 650150001524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001525 catalytic residue [active] 650150001526 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 650150001527 trimerization site [polypeptide binding]; other site 650150001528 active site 650150001529 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 650150001530 FeS assembly protein SufB; Region: sufB; TIGR01980 650150001531 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 650150001532 sugar efflux transporter; Region: 2A0120; TIGR00899 650150001533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150001534 putative substrate translocation pore; other site 650150001535 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 650150001536 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 650150001537 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 650150001538 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 650150001539 active site 650150001540 HIGH motif; other site 650150001541 dimer interface [polypeptide binding]; other site 650150001542 KMSKS motif; other site 650150001543 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150001544 RNA binding surface [nucleotide binding]; other site 650150001545 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 650150001546 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 650150001547 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150001548 RNA binding surface [nucleotide binding]; other site 650150001549 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 650150001550 Centromere/kinetochore Zw10; Region: Zw10; pfam06248 650150001551 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 650150001552 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 650150001553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150001554 catalytic residue [active] 650150001555 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 650150001556 THUMP domain; Region: THUMP; cl12076 650150001557 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 650150001558 Ligand Binding Site [chemical binding]; other site 650150001559 signal recognition particle protein; Provisional; Region: PRK10867 650150001560 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 650150001561 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 650150001562 P loop; other site 650150001563 GTP binding site [chemical binding]; other site 650150001564 Signal peptide binding domain; Region: SRP_SPB; pfam02978 650150001565 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 650150001566 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 650150001567 Catalytic site [active] 650150001568 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 650150001569 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 650150001570 GTP/Mg2+ binding site [chemical binding]; other site 650150001571 G4 box; other site 650150001572 G5 box; other site 650150001573 G1 box; other site 650150001574 Switch I region; other site 650150001575 G2 box; other site 650150001576 G3 box; other site 650150001577 Switch II region; other site 650150001578 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 650150001579 RNA/DNA hybrid binding site [nucleotide binding]; other site 650150001580 active site 650150001581 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 650150001582 DNA topoisomerase I; Validated; Region: PRK05582 650150001583 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 650150001584 active site 650150001585 interdomain interaction site; other site 650150001586 putative metal-binding site [ion binding]; other site 650150001587 nucleotide binding site [chemical binding]; other site 650150001588 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 650150001589 domain I; other site 650150001590 DNA binding groove [nucleotide binding] 650150001591 phosphate binding site [ion binding]; other site 650150001592 domain II; other site 650150001593 domain III; other site 650150001594 nucleotide binding site [chemical binding]; other site 650150001595 catalytic site [active] 650150001596 domain IV; other site 650150001597 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 650150001598 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 650150001599 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 650150001600 Glucose inhibited division protein A; Region: GIDA; pfam01134 650150001601 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 650150001602 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 650150001603 Int/Topo IB signature motif; other site 650150001604 active site 650150001605 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 650150001606 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 650150001607 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 650150001608 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 650150001609 FAD binding domain; Region: FAD_binding_4; pfam01565 650150001610 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 650150001611 integral membrane protein MviN; Region: mviN; TIGR01695 650150001612 cell division protein MraZ; Reviewed; Region: PRK00326 650150001613 MraZ protein; Region: MraZ; pfam02381 650150001614 MraZ protein; Region: MraZ; pfam02381 650150001615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150001616 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 650150001617 Septum formation initiator; Region: DivIC; cl11433 650150001618 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 650150001619 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150001620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 650150001621 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 650150001622 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 650150001623 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 650150001624 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 650150001625 Mg++ binding site [ion binding]; other site 650150001626 putative catalytic motif [active] 650150001627 putative substrate binding site [chemical binding]; other site 650150001628 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 650150001629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150001630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150001631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150001632 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 650150001633 DHH family; Region: DHH; pfam01368 650150001634 DHHA1 domain; Region: DHHA1; pfam02272 650150001635 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150001636 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 650150001637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150001638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 650150001639 synthetase active site [active] 650150001640 NTP binding site [chemical binding]; other site 650150001641 metal binding site [ion binding]; metal-binding site 650150001642 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 650150001643 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 650150001644 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 650150001645 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 650150001646 dimer interface [polypeptide binding]; other site 650150001647 motif 1; other site 650150001648 active site 650150001649 motif 2; other site 650150001650 motif 3; other site 650150001651 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 650150001652 anticodon binding site; other site 650150001653 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 650150001654 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 650150001655 dimer interface [polypeptide binding]; other site 650150001656 anticodon binding site; other site 650150001657 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150001658 motif 1; other site 650150001659 dimer interface [polypeptide binding]; other site 650150001660 active site 650150001661 motif 2; other site 650150001662 GAD domain; Region: GAD; pfam02938 650150001663 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150001664 active site 650150001665 motif 3; other site 650150001666 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 650150001667 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 650150001668 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 650150001669 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 650150001670 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 650150001671 23S rRNA binding site [nucleotide binding]; other site 650150001672 L21 binding site [polypeptide binding]; other site 650150001673 L13 binding site [polypeptide binding]; other site 650150001674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001675 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150001676 Phosphotransferase enzyme family; Region: APH; pfam01636 650150001677 active site 650150001678 ATP binding site [chemical binding]; other site 650150001679 substrate binding site [chemical binding]; other site 650150001680 dimer interface [polypeptide binding]; other site 650150001681 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 650150001682 active site 650150001683 dimerization interface [polypeptide binding]; other site 650150001684 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 650150001685 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 650150001686 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 650150001687 homotrimer interaction site [polypeptide binding]; other site 650150001688 putative active site [active] 650150001689 Uncharacterized conserved protein [Function unknown]; Region: COG1284 650150001690 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150001691 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150001692 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 650150001693 S-adenosylmethionine synthetase; Validated; Region: PRK05250 650150001694 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 650150001695 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 650150001696 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 650150001697 hypothetical protein; Provisional; Region: PRK13670 650150001698 hypothetical protein; Provisional; Region: PRK13671 650150001699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150001700 S-adenosylmethionine binding site [chemical binding]; other site 650150001701 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150001702 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 650150001703 oligomer interface [polypeptide binding]; other site 650150001704 active site 650150001705 metal binding site [ion binding]; metal-binding site 650150001706 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 650150001707 putative active site [active] 650150001708 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150001709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150001710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150001711 catabolite control protein A; Region: ccpA; TIGR01481 650150001712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150001713 DNA binding site [nucleotide binding] 650150001714 domain linker motif; other site 650150001715 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 650150001716 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...; Region: GH85_ENGase; cd06547 650150001717 putative active site [active] 650150001718 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 650150001719 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 650150001720 nudix motif; other site 650150001721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150001722 S-adenosylmethionine binding site [chemical binding]; other site 650150001723 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 650150001724 active site 650150001725 metal binding site [ion binding]; metal-binding site 650150001726 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150001727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150001728 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 650150001729 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 650150001730 active site 650150001731 catalytic residues [active] 650150001732 metal binding site [ion binding]; metal-binding site 650150001733 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 650150001734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150001735 S-adenosylmethionine binding site [chemical binding]; other site 650150001736 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 650150001737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150001738 HrcA protein C terminal domain; Region: HrcA; pfam01628 650150001739 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 650150001740 dimer interface [polypeptide binding]; other site 650150001741 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 650150001742 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 650150001743 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 650150001744 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 650150001745 HSP70 interaction site [polypeptide binding]; other site 650150001746 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 650150001747 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 650150001748 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 650150001749 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 650150001750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150001751 Walker A motif; other site 650150001752 ATP binding site [chemical binding]; other site 650150001753 Walker B motif; other site 650150001754 arginine finger; other site 650150001755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150001756 Walker A motif; other site 650150001757 ATP binding site [chemical binding]; other site 650150001758 Walker B motif; other site 650150001759 arginine finger; other site 650150001760 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 650150001761 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 650150001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150001763 Coenzyme A binding pocket [chemical binding]; other site 650150001764 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 650150001765 AMP deaminase; Provisional; Region: PTZ00310 650150001766 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 650150001767 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 650150001768 bacteriophage 650150001769 Phage integrase family; Region: Phage_integrase; pfam00589 650150001770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 650150001771 DNA binding site [nucleotide binding] 650150001772 Int/Topo IB signature motif; other site 650150001773 active site 650150001774 Abi-like protein; Region: Abi_2; cl01988 650150001775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150001776 non-specific DNA binding site [nucleotide binding]; other site 650150001777 salt bridge; other site 650150001778 sequence-specific DNA binding site [nucleotide binding]; other site 650150001779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150001780 non-specific DNA binding site [nucleotide binding]; other site 650150001781 salt bridge; other site 650150001782 sequence-specific DNA binding site [nucleotide binding]; other site 650150001783 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 650150001784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001785 Walker A/P-loop; other site 650150001786 ATP binding site [chemical binding]; other site 650150001787 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 650150001788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150001789 ATP binding site [chemical binding]; other site 650150001790 putative Mg++ binding site [ion binding]; other site 650150001791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150001792 nucleotide binding region [chemical binding]; other site 650150001793 ATP-binding site [chemical binding]; other site 650150001794 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 650150001795 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 650150001796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001797 Walker A motif; other site 650150001798 ATP binding site [chemical binding]; other site 650150001799 Walker B motif; other site 650150001800 Endodeoxyribonuclease RusA; Region: RusA; cl01885 650150001801 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 650150001802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 650150001803 Terminase-like family; Region: Terminase_6; pfam03237 650150001804 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 650150001805 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 650150001806 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 650150001807 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 650150001808 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators...; Region: VIP2; cl00173 650150001809 active site 650150001810 conformational flexibility of ligand binding pocket; other site 650150001811 ADP-ribosylating toxin turn-turn motif; other site 650150001812 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 650150001813 Phage major tail protein 2; Region: Phage_tail_2; cl11463 650150001814 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 650150001815 Phage-related protein [Function unknown]; Region: COG5412 650150001816 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 650150001817 V-type ATP synthase subunit I; Validated; Region: PRK05771 650150001818 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 650150001819 NlpC/P60 family; Region: NLPC_P60; cl11438 650150001820 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150001821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150001822 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 650150001823 putative ADP-binding pocket [chemical binding]; other site 650150001824 RecX family; Region: RecX; cl00936 650150001825 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 650150001826 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 650150001827 generic binding surface I; other site 650150001828 generic binding surface II; other site 650150001829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150001830 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 650150001831 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 650150001832 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 650150001833 RimM N-terminal domain; Region: RimM; pfam01782 650150001834 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 650150001835 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 650150001836 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150001837 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150001838 Integrase core domain; Region: rve; cl01316 650150001839 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 650150001840 aspartate aminotransferase; Provisional; Region: PRK08361 650150001841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150001842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150001843 homodimer interface [polypeptide binding]; other site 650150001844 catalytic residue [active] 650150001845 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 650150001846 rRNA interaction site [nucleotide binding]; other site 650150001847 S8 interaction site; other site 650150001848 putative laminin-1 binding site; other site 650150001849 elongation factor Ts; Provisional; Region: tsf; PRK09377 650150001850 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 650150001851 Elongation factor TS; Region: EF_TS; pfam00889 650150001852 Elongation factor TS; Region: EF_TS; pfam00889 650150001853 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 650150001854 putative nucleotide binding site [chemical binding]; other site 650150001855 uridine monophosphate binding site [chemical binding]; other site 650150001856 homohexameric interface [polypeptide binding]; other site 650150001857 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 650150001858 hinge region; other site 650150001859 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 650150001860 catalytic residue [active] 650150001861 putative FPP diphosphate binding site; other site 650150001862 putative FPP binding hydrophobic cleft; other site 650150001863 dimer interface [polypeptide binding]; other site 650150001864 putative IPP diphosphate binding site; other site 650150001865 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 650150001866 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 650150001867 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 650150001868 active site 650150001869 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 650150001870 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 650150001871 putative substrate binding region [chemical binding]; other site 650150001872 replicative DNA helicase; Provisional; Region: PRK09165 650150001873 Haemolysin-III related; Region: HlyIII; cl03831 650150001874 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 650150001875 Dockerin type I repeat; Region: Dockerin_1; pfam00404 650150001876 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 650150001877 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 650150001878 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 650150001879 endonuclease III; Region: ENDO3c; smart00478 650150001880 minor groove reading motif; other site 650150001881 helix-hairpin-helix signature motif; other site 650150001882 substrate binding pocket [chemical binding]; other site 650150001883 active site 650150001884 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150001885 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 650150001886 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150001887 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 650150001888 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 650150001889 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 650150001890 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 650150001891 alanine racemase; Reviewed; Region: alr; PRK00053 650150001892 active site 650150001893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 650150001894 dimer interface [polypeptide binding]; other site 650150001895 substrate binding site [chemical binding]; other site 650150001896 catalytic residues [active] 650150001897 Transglycosylase; Region: Transgly; cl07896 650150001898 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 650150001899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 650150001900 Recombination protein U; Region: RecU; cl01314 650150001901 cell division protein GpsB; Provisional; Region: PRK14127 650150001902 DivIVA domain; Region: DivI1A_domain; TIGR03544 650150001903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 650150001904 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 650150001905 recombinase A; Provisional; Region: recA; PRK09354 650150001906 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 650150001907 hexamer interface [polypeptide binding]; other site 650150001908 Walker A motif; other site 650150001909 ATP binding site [chemical binding]; other site 650150001910 Walker B motif; other site 650150001911 phosphodiesterase; Provisional; Region: PRK12704 650150001912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150001913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 650150001914 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 650150001915 putative active site [active] 650150001916 metal binding site [ion binding]; metal-binding site 650150001917 homodimer binding site [polypeptide binding]; other site 650150001918 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 650150001919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150001920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150001921 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 650150001922 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150001923 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001924 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001925 domain interaction interfaces; other site 650150001926 putative Ca2+ binding sites [ion binding]; other site 650150001927 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001928 domain interaction interfaces; other site 650150001929 putative Ca2+ binding sites [ion binding]; other site 650150001930 putative ligand binding motif; other site 650150001931 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001932 putative Ca2+ binding sites [ion binding]; other site 650150001933 domain interaction interfaces; other site 650150001934 putative ligand binding motif; other site 650150001935 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001936 putative Ca2+ binding sites [ion binding]; other site 650150001937 domain interaction interfaces; other site 650150001938 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001939 putative Ca2+ binding sites [ion binding]; other site 650150001940 domain interaction interfaces; other site 650150001941 putative ligand binding motif; other site 650150001942 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001943 domain interaction interfaces; other site 650150001944 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001945 putative Ca2+ binding sites [ion binding]; other site 650150001946 domain interaction interfaces; other site 650150001947 putative ligand binding motif; other site 650150001948 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001949 putative Ca2+ binding sites [ion binding]; other site 650150001950 domain interaction interfaces; other site 650150001951 putative ligand binding motif; other site 650150001952 Collagen binding domain; Region: Collagen_bind; pfam05737 650150001953 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150001954 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001955 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150001956 domain interaction interfaces; other site 650150001957 putative ligand binding motif; other site 650150001958 putative Ca2+ binding sites [ion binding]; other site 650150001959 prolyl-tRNA synthetase; Provisional; Region: PRK09194 650150001960 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 650150001961 dimer interface [polypeptide binding]; other site 650150001962 motif 1; other site 650150001963 active site 650150001964 motif 2; other site 650150001965 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 650150001966 putative deacylase active site [active] 650150001967 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150001968 active site 650150001969 motif 3; other site 650150001970 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 650150001971 anticodon binding site; other site 650150001972 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 650150001973 glycosyl transferase, family 51, pseudogene, truncated by frameshift mutation 650150001974 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 650150001975 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 650150001976 active site 650150001977 HIGH motif; other site 650150001978 dimer interface [polypeptide binding]; other site 650150001979 KMSKS motif; other site 650150001980 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 650150001981 putative catalytic residues [active] 650150001982 thiol/disulfide switch; other site 650150001983 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 650150001984 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 650150001985 Ligand Binding Site [chemical binding]; other site 650150001986 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 650150001987 RecD/TraA family; Region: recD_rel; TIGR01448 650150001988 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150001989 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150001990 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 650150001991 aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893 650150001992 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 650150001993 metal binding site [ion binding]; metal-binding site 650150001994 dimer interface [polypeptide binding]; other site 650150001995 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 650150001996 HPr interaction site; other site 650150001997 glycerol kinase (GK) interaction site [polypeptide binding]; other site 650150001998 active site 650150001999 phosphorylation site [posttranslational modification] 650150002000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 650150002001 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 650150002002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150002003 putative transposase OrfB; Reviewed; Region: PHA02517 650150002004 Integrase core domain; Region: rve; cl01316 650150002005 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150002006 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150002007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002008 Walker A/P-loop; other site 650150002009 ATP binding site [chemical binding]; other site 650150002010 Q-loop/lid; other site 650150002011 ABC transporter signature motif; other site 650150002012 Walker B; other site 650150002013 D-loop; other site 650150002014 H-loop/switch region; other site 650150002015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150002016 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150002017 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 650150002018 CLI_3235-class bacteriocin maturation radical SAM enzyme; Region: rSAM_ocin_clost; TIGR04068 650150002019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 650150002020 FeS/SAM binding site; other site 650150002021 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150002022 putative transposase OrfB; Reviewed; Region: PHA02517 650150002023 Integrase core domain; Region: rve; cl01316 650150002024 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 650150002025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002026 ABC transporter signature motif; other site 650150002027 Walker B; other site 650150002028 D-loop; other site 650150002029 H-loop/switch region; other site 650150002030 Integrase core domain; Region: rve; cl01316 650150002031 putative transposase OrfB; Reviewed; Region: PHA02517 650150002032 FtsX-like permease family; Region: FtsX; pfam02687 650150002033 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 650150002034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002035 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150002036 Walker A/P-loop; other site 650150002037 ATP binding site [chemical binding]; other site 650150002038 Q-loop/lid; other site 650150002039 ABC transporter signature motif; other site 650150002040 Walker B; other site 650150002041 D-loop; other site 650150002042 H-loop/switch region; other site 650150002043 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002044 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150002045 Walker A/P-loop; other site 650150002046 ATP binding site [chemical binding]; other site 650150002047 Q-loop/lid; other site 650150002048 ABC transporter signature motif; other site 650150002049 Walker B; other site 650150002050 D-loop; other site 650150002051 H-loop/switch region; other site 650150002052 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 650150002053 putative active site [active] 650150002054 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002055 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150002056 Walker A/P-loop; other site 650150002057 ATP binding site [chemical binding]; other site 650150002058 Q-loop/lid; other site 650150002059 ABC transporter signature motif; other site 650150002060 Walker B; other site 650150002061 D-loop; other site 650150002062 H-loop/switch region; other site 650150002063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 650150002064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 650150002065 active site 650150002066 catalytic tetrad [active] 650150002067 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 650150002068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150002069 Coenzyme A binding pocket [chemical binding]; other site 650150002070 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 650150002071 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 650150002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150002073 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 650150002074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150002075 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 650150002076 active site 650150002077 phosphorylation site [posttranslational modification] 650150002078 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 650150002079 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 650150002080 P-loop; other site 650150002081 active site 650150002082 phosphorylation site [posttranslational modification] 650150002083 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 650150002084 active site 650150002085 dimer interface [polypeptide binding]; other site 650150002086 magnesium binding site [ion binding]; other site 650150002087 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 650150002088 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 650150002089 AP (apurinic/apyrimidinic) site pocket; other site 650150002090 DNA interaction; other site 650150002091 Metal-binding active site; metal-binding site 650150002092 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 650150002093 intersubunit interface [polypeptide binding]; other site 650150002094 active site 650150002095 Zn2+ binding site [ion binding]; other site 650150002096 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 650150002097 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 650150002098 Malic enzyme, N-terminal domain; Region: malic; pfam00390 650150002099 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 650150002100 putative NAD(P) binding site [chemical binding]; other site 650150002101 fumarate hydratase; Reviewed; Region: fumC; PRK00485 650150002102 Class II fumarases; Region: Fumarase_classII; cd01362 650150002103 active site 650150002104 tetramer interface [polypeptide binding]; other site 650150002105 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 650150002106 Aspartase; Region: Aspartase; cd01357 650150002107 active sites [active] 650150002108 tetramer interface [polypeptide binding]; other site 650150002109 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150002110 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150002111 Walker A/P-loop; other site 650150002112 ATP binding site [chemical binding]; other site 650150002113 Q-loop/lid; other site 650150002114 ABC transporter signature motif; other site 650150002115 Walker B; other site 650150002116 D-loop; other site 650150002117 H-loop/switch region; other site 650150002118 DNA polymerase IV; Reviewed; Region: PRK03103 650150002119 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 650150002120 active site 650150002121 DNA binding site [nucleotide binding] 650150002122 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1...; Region: GH20_DspB_LnbB-like; cd06564 650150002123 active site 650150002124 choline-binding protein, pseudogene, truncated by frameshift mutation 650150002125 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 650150002126 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 650150002127 FMN binding site [chemical binding]; other site 650150002128 active site 650150002129 catalytic residues [active] 650150002130 substrate binding site [chemical binding]; other site 650150002131 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 650150002132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150002133 ATP binding site [chemical binding]; other site 650150002134 putative Mg++ binding site [ion binding]; other site 650150002135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002136 nucleotide binding region [chemical binding]; other site 650150002137 ATP-binding site [chemical binding]; other site 650150002138 RQC domain; Region: RQC; pfam09382 650150002139 HRDC domain; Region: HRDC; cl02578 650150002140 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150002141 D-lactate dehydrogenase; Validated; Region: PRK08605 650150002142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150002143 Transcriptional regulators [Transcription]; Region: GntR; COG1802 650150002144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150002145 DNA-binding site [nucleotide binding]; DNA binding site 650150002146 FCD domain; Region: FCD; cl11656 650150002147 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 650150002148 BioY family; Region: BioY; cl00560 650150002149 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 650150002150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150002151 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 650150002152 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 650150002153 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 650150002154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150002155 active site 650150002156 nucleotide binding site [chemical binding]; other site 650150002157 HIGH motif; other site 650150002158 KMSKS motif; other site 650150002159 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 650150002160 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 650150002161 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 650150002162 Coenzyme A transferase; Region: CoA_trans; cl00773 650150002163 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 650150002164 oxaloacetate decarboxylase; Provisional; Region: PRK12331 650150002165 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 650150002166 active site 650150002167 catalytic residues [active] 650150002168 metal binding site [ion binding]; metal-binding site 650150002169 homodimer binding site [polypeptide binding]; other site 650150002170 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 650150002171 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 650150002172 carboxyltransferase (CT) interaction site; other site 650150002173 biotinylation site [posttranslational modification]; other site 650150002174 subunit; Region: OAD_beta; cl00816 650150002175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150002176 putative transposase OrfB; Reviewed; Region: PHA02517 650150002177 Integrase core domain; Region: rve; cl01316 650150002178 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 650150002179 Asp-box motif; other site 650150002180 A new structural DNA glycosylase; Region: AlkD_like; cl11434 650150002181 Active site [active] 650150002182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643 650150002183 FOG: CBS domain [General function prediction only]; Region: COG0517 650150002184 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 650150002185 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 650150002186 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 650150002187 substrate binding site [chemical binding]; other site 650150002188 catalytic residues [active] 650150002189 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150002190 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 650150002191 Uncharacterized conserved protein [Function unknown]; Region: COG2433 650150002192 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 650150002193 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150002194 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 650150002195 Nuclease-related domain; Region: NERD; pfam08378 650150002196 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 650150002197 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 650150002198 LicD family; Region: LicD; cl01378 650150002199 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 650150002200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150002201 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150002202 active site 650150002203 motif I; other site 650150002204 motif II; other site 650150002205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150002206 MepB protein; Region: MepB; cl01985 650150002207 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 650150002208 Peptidase family C69; Region: Peptidase_C69; cl01920 650150002209 Protein of unknown function DUF124; Region: DUF124; cl00884 650150002210 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 650150002211 active site 650150002212 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 650150002213 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 650150002214 domain; Region: Glyco_hydro_2; pfam00703 650150002215 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 650150002216 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002217 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002218 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 650150002219 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002220 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 650150002221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150002222 Coenzyme A binding pocket [chemical binding]; other site 650150002223 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 650150002224 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 650150002225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 650150002226 putative substrate translocation pore; other site 650150002227 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 650150002228 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 650150002229 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 650150002230 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 650150002231 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150002233 Integrase core domain; Region: rve; cl01316 650150002234 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 650150002235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150002236 RNA binding surface [nucleotide binding]; other site 650150002237 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 650150002238 active site 650150002239 Protein of unknown function (DUF454); Region: DUF454; cl01063 650150002240 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 650150002241 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150002242 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 650150002243 Walker A/P-loop; other site 650150002244 ATP binding site [chemical binding]; other site 650150002245 Q-loop/lid; other site 650150002246 ABC transporter signature motif; other site 650150002247 Walker B; other site 650150002248 D-loop; other site 650150002249 H-loop/switch region; other site 650150002250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150002251 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150002252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002253 Walker A/P-loop; other site 650150002254 ATP binding site [chemical binding]; other site 650150002255 Q-loop/lid; other site 650150002256 ABC transporter signature motif; other site 650150002257 Walker B; other site 650150002258 D-loop; other site 650150002259 H-loop/switch region; other site 650150002260 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 650150002261 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 650150002262 DNA binding site [nucleotide binding] 650150002263 active site 650150002264 Amidinotransferase; Region: Amidinotransf; cl12043 650150002265 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 650150002266 ornithine carbamoyltransferase; Validated; Region: PRK02102 650150002267 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 650150002268 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 650150002269 carbamate kinase; Reviewed; Region: PRK12686 650150002270 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 650150002271 putative substrate binding site [chemical binding]; other site 650150002272 nucleotide binding site [chemical binding]; other site 650150002273 nucleotide binding site [chemical binding]; other site 650150002274 homodimer interface [polypeptide binding]; other site 650150002275 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150002276 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 650150002277 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 650150002278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150002279 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 650150002280 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 650150002281 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 650150002282 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 650150002283 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 650150002284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 650150002285 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150002286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150002287 active site 650150002288 phosphorylation site [posttranslational modification] 650150002289 intermolecular recognition site; other site 650150002290 dimerization interface [polypeptide binding]; other site 650150002291 LytTr DNA-binding domain; Region: LytTR; cl04498 650150002292 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 650150002293 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150002294 Walker A/P-loop; other site 650150002295 ATP binding site [chemical binding]; other site 650150002296 Q-loop/lid; other site 650150002297 ABC transporter signature motif; other site 650150002298 Walker B; other site 650150002299 D-loop; other site 650150002300 H-loop/switch region; other site 650150002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150002302 non-specific DNA binding site [nucleotide binding]; other site 650150002303 salt bridge; other site 650150002304 sequence-specific DNA binding site [nucleotide binding]; other site 650150002305 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 650150002306 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 650150002307 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150002308 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 650150002309 hydrophobic ligand binding site; other site 650150002310 Uncharacterized conserved protein [Function unknown]; Region: COG3589 650150002311 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150002312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150002313 DNA-binding site [nucleotide binding]; DNA binding site 650150002314 UTRA domain; Region: UTRA; cl06649 650150002315 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150002316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002317 Walker A/P-loop; other site 650150002318 ATP binding site [chemical binding]; other site 650150002319 ABC transporter signature motif; other site 650150002320 Walker B; other site 650150002321 D-loop; other site 650150002322 H-loop/switch region; other site 650150002323 ABC transporter; Region: ABC_tran_2; pfam12848 650150002324 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150002325 G5 domain; Region: G5; pfam07501 650150002326 VanZ like family; Region: VanZ; cl01971 650150002327 Cupin domain; Region: Cupin_2; cl09118 650150002328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150002329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150002330 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 650150002331 TadE-like protein; Region: TadE; pfam07811 650150002332 SAF domain; Region: SAF; cl00555 650150002333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 650150002334 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 650150002335 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 650150002336 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 650150002337 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 650150002338 ATP binding site [chemical binding]; other site 650150002339 Walker A motif; other site 650150002340 hexamer interface [polypeptide binding]; other site 650150002341 Walker B motif; other site 650150002342 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 650150002343 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 650150002344 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 650150002345 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 650150002346 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 650150002347 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 650150002348 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 650150002349 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 650150002350 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 650150002351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150002352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150002353 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 650150002354 Predicted membrane protein [Function unknown]; Region: COG1511 650150002355 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 650150002356 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150002358 Integrase core domain; Region: rve; cl01316 650150002359 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 650150002360 competence damage-inducible protein A; Provisional; Region: PRK00549 650150002361 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 650150002362 putative MPT binding site; other site 650150002363 Competence-damaged protein; Region: CinA; cl00666 650150002364 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 650150002365 active site clefts [active] 650150002366 zinc binding site [ion binding]; other site 650150002367 dimer interface [polypeptide binding]; other site 650150002368 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 650150002369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150002370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002371 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150002372 ABC transporter; Region: ABC_tran_2; pfam12848 650150002373 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150002374 VanZ like family; Region: VanZ; cl01971 650150002375 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150002376 Uncharacterized conserved protein [Function unknown]; Region: COG3589 650150002377 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150002378 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150002379 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150002380 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 650150002381 putative active site [active] 650150002382 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 650150002383 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 650150002384 putative active site [active] 650150002385 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 650150002386 Bacterial sugar transferase; Region: Bac_transf; cl00939 650150002387 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 650150002388 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 650150002389 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 650150002390 NAD(P) binding site [chemical binding]; other site 650150002391 homodimer interface [polypeptide binding]; other site 650150002392 substrate binding site [chemical binding]; other site 650150002393 active site 650150002394 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 650150002395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150002396 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 650150002397 NAD(P) binding site [chemical binding]; other site 650150002398 active site 650150002399 Cupin domain; Region: Cupin_2; cl09118 650150002400 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 650150002401 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 650150002402 active site 650150002403 homodimer interface [polypeptide binding]; other site 650150002404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 650150002405 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150002406 active site 650150002407 Phosphotransferase enzyme family; Region: APH; pfam01636 650150002408 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150002409 active site 650150002410 ATP binding site [chemical binding]; other site 650150002411 substrate binding site [chemical binding]; other site 650150002412 dimer interface [polypeptide binding]; other site 650150002413 LicD family; Region: LicD; cl01378 650150002414 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 650150002415 active site 650150002416 metal binding site [ion binding]; metal-binding site 650150002417 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150002418 Phosphotransferase enzyme family; Region: APH; pfam01636 650150002419 active site 650150002420 ATP binding site [chemical binding]; other site 650150002421 substrate binding site [chemical binding]; other site 650150002422 dimer interface [polypeptide binding]; other site 650150002423 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 650150002424 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 650150002425 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 650150002426 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 650150002427 CoenzymeA binding site [chemical binding]; other site 650150002428 subunit interaction site [polypeptide binding]; other site 650150002429 PHB binding site; other site 650150002430 DsrE/DsrF-like family; Region: DrsE; cl00672 650150002431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150002432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150002433 active site 650150002434 phosphorylation site [posttranslational modification] 650150002435 intermolecular recognition site; other site 650150002436 dimerization interface [polypeptide binding]; other site 650150002437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150002438 DNA binding site [nucleotide binding] 650150002439 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 650150002440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150002441 dimer interface [polypeptide binding]; other site 650150002442 phosphorylation site [posttranslational modification] 650150002443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002444 ATP binding site [chemical binding]; other site 650150002445 Mg2+ binding site [ion binding]; other site 650150002446 G-X-G motif; other site 650150002447 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 650150002448 FtsX-like permease family; Region: FtsX; pfam02687 650150002449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002450 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150002451 Walker A/P-loop; other site 650150002452 ATP binding site [chemical binding]; other site 650150002453 Q-loop/lid; other site 650150002454 ABC transporter signature motif; other site 650150002455 Walker B; other site 650150002456 D-loop; other site 650150002457 H-loop/switch region; other site 650150002458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 650150002459 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 650150002460 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 650150002461 active site 650150002462 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 650150002463 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 650150002464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150002465 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 650150002466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002467 Walker A/P-loop; other site 650150002468 ATP binding site [chemical binding]; other site 650150002469 Q-loop/lid; other site 650150002470 ABC transporter signature motif; other site 650150002471 Walker B; other site 650150002472 D-loop; other site 650150002473 H-loop/switch region; other site 650150002474 TOBE domain; Region: TOBE_2; cl01440 650150002475 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150002476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150002477 dimer interface [polypeptide binding]; other site 650150002478 conserved gate region; other site 650150002479 putative PBP binding loops; other site 650150002480 ABC-ATPase subunit interface; other site 650150002481 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150002482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150002483 dimer interface [polypeptide binding]; other site 650150002484 conserved gate region; other site 650150002485 putative PBP binding loops; other site 650150002486 ABC-ATPase subunit interface; other site 650150002487 Sulfatase; Region: Sulfatase; cl10460 650150002488 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 650150002489 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 650150002490 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 650150002491 DNA binding site [nucleotide binding] 650150002492 Int/Topo IB signature motif; other site 650150002493 active site 650150002494 DNA polymerase IV; Validated; Region: PRK01810 650150002495 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 650150002496 active site 650150002497 DNA binding site [nucleotide binding] 650150002498 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 650150002499 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 650150002500 Walker A/P-loop; other site 650150002501 ATP binding site [chemical binding]; other site 650150002502 Q-loop/lid; other site 650150002503 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 650150002504 ABC transporter signature motif; other site 650150002505 Walker B; other site 650150002506 D-loop; other site 650150002507 H-loop/switch region; other site 650150002508 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 650150002509 TPP-binding site [chemical binding]; other site 650150002510 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 650150002511 PYR/PP interface [polypeptide binding]; other site 650150002512 dimer interface [polypeptide binding]; other site 650150002513 TPP binding site [chemical binding]; other site 650150002514 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 650150002515 substrate binding pocket [chemical binding]; other site 650150002516 chain length determination region; other site 650150002517 substrate-Mg2+ binding site; other site 650150002518 catalytic residues [active] 650150002519 aspartate-rich region 1; other site 650150002520 active site lid residues [active] 650150002521 aspartate-rich region 2; other site 650150002522 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 650150002523 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 650150002524 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 650150002525 generic binding surface II; other site 650150002526 generic binding surface I; other site 650150002527 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 650150002528 Protein of unknown function (DUF322); Region: DUF322; cl00574 650150002529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150002530 Uncharacterized conserved protein [Function unknown]; Region: COG3270 650150002531 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 650150002532 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 650150002533 active site 650150002534 Riboflavin kinase; Region: Flavokinase; pfam01687 650150002535 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 650150002536 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 650150002537 RNA binding site [nucleotide binding]; other site 650150002538 active site 650150002539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 650150002540 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 650150002541 substrate binding pocket [chemical binding]; other site 650150002542 membrane-bound complex binding site; other site 650150002543 hinge residues; other site 650150002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150002545 dimer interface [polypeptide binding]; other site 650150002546 conserved gate region; other site 650150002547 putative PBP binding loops; other site 650150002548 ABC-ATPase subunit interface; other site 650150002549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 650150002550 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 650150002551 Walker A/P-loop; other site 650150002552 ATP binding site [chemical binding]; other site 650150002553 Q-loop/lid; other site 650150002554 ABC transporter signature motif; other site 650150002555 Walker B; other site 650150002556 D-loop; other site 650150002557 H-loop/switch region; other site 650150002558 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150002560 Integrase core domain; Region: rve; cl01316 650150002561 Ribosome-binding factor A; Region: RBFA; cl00542 650150002562 translation initiation factor IF-2; Region: IF-2; TIGR00487 650150002563 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 650150002564 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 650150002565 G1 box; other site 650150002566 putative GEF interaction site [polypeptide binding]; other site 650150002567 GTP/Mg2+ binding site [chemical binding]; other site 650150002568 Switch I region; other site 650150002569 G2 box; other site 650150002570 G3 box; other site 650150002571 Switch II region; other site 650150002572 G4 box; other site 650150002573 G5 box; other site 650150002574 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 650150002575 Translation-initiation factor 2; Region: IF-2; pfam11987 650150002576 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 650150002577 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 650150002578 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 650150002579 putative RNA binding cleft [nucleotide binding]; other site 650150002580 NusA N-terminal domain; Region: NusA_N; pfam08529 650150002581 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 650150002582 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 650150002583 RNA binding site [nucleotide binding]; other site 650150002584 homodimer interface [polypeptide binding]; other site 650150002585 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 650150002586 G-X-X-G motif; other site 650150002587 ribosome maturation protein RimP; Reviewed; Region: PRK00092 650150002588 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 650150002589 Sm1 motif; other site 650150002590 D3 - B interaction site; other site 650150002591 D1 - D2 interaction site; other site 650150002592 Hfq - Hfq interaction site; other site 650150002593 RNA binding pocket [nucleotide binding]; other site 650150002594 Sm2 motif; other site 650150002595 DNA polymerase III PolC; Validated; Region: polC; PRK00448 650150002596 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 650150002597 generic binding surface II; other site 650150002598 generic binding surface I; other site 650150002599 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 650150002600 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 650150002601 active site 650150002602 substrate binding site [chemical binding]; other site 650150002603 catalytic site [active] 650150002604 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 650150002605 ribonuclease III; Reviewed; Region: rnc; PRK00102 650150002606 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 650150002607 dimerization interface [polypeptide binding]; other site 650150002608 active site 650150002609 metal binding site [ion binding]; metal-binding site 650150002610 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 650150002611 dsRNA binding site [nucleotide binding]; other site 650150002612 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 650150002613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150002614 ATP binding site [chemical binding]; other site 650150002615 putative Mg++ binding site [ion binding]; other site 650150002616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002617 nucleotide binding region [chemical binding]; other site 650150002618 ATP-binding site [chemical binding]; other site 650150002619 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 650150002620 DAK2 domain; Region: Dak2; cl03685 650150002621 Protein of unknown function (DUF322); Region: DUF322; cl00574 650150002622 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 650150002623 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 650150002624 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 650150002625 active site 650150002626 homodimer interface [polypeptide binding]; other site 650150002627 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 650150002628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150002629 Walker A motif; other site 650150002630 ATP binding site [chemical binding]; other site 650150002631 Walker B motif; other site 650150002632 arginine finger; other site 650150002633 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 650150002634 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 650150002635 RuvA N terminal domain; Region: RuvA_N; pfam01330 650150002636 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 650150002637 GTPase CgtA; Reviewed; Region: obgE; PRK12297 650150002638 GTP1/OBG; Region: GTP1_OBG; pfam01018 650150002639 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 650150002640 G1 box; other site 650150002641 GTP/Mg2+ binding site [chemical binding]; other site 650150002642 Switch I region; other site 650150002643 G2 box; other site 650150002644 G3 box; other site 650150002645 Switch II region; other site 650150002646 G4 box; other site 650150002647 G5 box; other site 650150002648 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 650150002649 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 650150002650 Protein of unknown function (DUF464); Region: DUF464; cl01080 650150002651 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 650150002652 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 650150002653 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 650150002654 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150002655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150002656 Integrase core domain; Region: rve; cl01316 650150002657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150002658 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 650150002659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150002660 dimer interface [polypeptide binding]; other site 650150002661 phosphorylation site [posttranslational modification] 650150002662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002663 ATP binding site [chemical binding]; other site 650150002664 Mg2+ binding site [ion binding]; other site 650150002665 G-X-G motif; other site 650150002666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150002667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150002668 active site 650150002669 phosphorylation site [posttranslational modification] 650150002670 intermolecular recognition site; other site 650150002671 dimerization interface [polypeptide binding]; other site 650150002672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150002673 DNA binding site [nucleotide binding] 650150002674 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 650150002675 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 650150002676 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 650150002677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 650150002678 generic binding surface II; other site 650150002679 generic binding surface I; other site 650150002680 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 650150002681 DHH family; Region: DHH; pfam01368 650150002682 Acetokinase family; Region: Acetate_kinase; cl01029 650150002683 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 650150002684 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 650150002685 DNA binding residues [nucleotide binding] 650150002686 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 650150002687 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 650150002688 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 650150002689 P loop; other site 650150002690 GTP binding site [chemical binding]; other site 650150002691 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 650150002692 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 650150002693 Walker A/P-loop; other site 650150002694 ATP binding site [chemical binding]; other site 650150002695 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 650150002696 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 650150002697 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 650150002698 ABC transporter signature motif; other site 650150002699 Walker B; other site 650150002700 D-loop; other site 650150002701 H-loop/switch region; other site 650150002702 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 650150002703 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 650150002704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150002705 Domain of unknown function DUF143; Region: DUF143; cl00519 650150002706 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 650150002707 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 650150002708 active site 650150002709 (T/H)XGH motif; other site 650150002710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150002711 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 650150002712 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 650150002713 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 650150002714 GTP/Mg2+ binding site [chemical binding]; other site 650150002715 G4 box; other site 650150002716 G5 box; other site 650150002717 G1 box; other site 650150002718 Switch I region; other site 650150002719 G2 box; other site 650150002720 G3 box; other site 650150002721 Switch II region; other site 650150002722 adenylosuccinate lyase; Provisional; Region: PRK07492 650150002723 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 650150002724 tetramer interface [polypeptide binding]; other site 650150002725 active site 650150002726 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 650150002727 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 650150002728 CAP-like domain; other site 650150002729 Active site [active] 650150002730 primary dimer interface [polypeptide binding]; other site 650150002731 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 650150002732 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 650150002733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002734 ATP binding site [chemical binding]; other site 650150002735 Mg2+ binding site [ion binding]; other site 650150002736 G-X-G motif; other site 650150002737 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 650150002738 anchoring element; other site 650150002739 dimer interface [polypeptide binding]; other site 650150002740 ATP binding site [chemical binding]; other site 650150002741 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 650150002742 active site 650150002743 putative metal-binding site [ion binding]; other site 650150002744 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 650150002745 Domain of unknown function (DUF205); Region: DUF205; cl00410 650150002746 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 650150002747 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150002748 Walker A/P-loop; other site 650150002749 ATP binding site [chemical binding]; other site 650150002750 Q-loop/lid; other site 650150002751 ABC transporter signature motif; other site 650150002752 Walker B; other site 650150002753 D-loop; other site 650150002754 H-loop/switch region; other site 650150002755 Domain of unknown function DUF28; Region: DUF28; cl00361 650150002756 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 650150002757 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 650150002758 putative tRNA-binding site [nucleotide binding]; other site 650150002759 B3/4 domain; Region: B3_4; cl11458 650150002760 tRNA synthetase B5 domain; Region: B5; cl08394 650150002761 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 650150002762 dimer interface [polypeptide binding]; other site 650150002763 motif 1; other site 650150002764 motif 3; other site 650150002765 motif 2; other site 650150002766 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 650150002767 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 650150002768 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 650150002769 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 650150002770 dimer interface [polypeptide binding]; other site 650150002771 motif 1; other site 650150002772 active site 650150002773 motif 2; other site 650150002774 motif 3; other site 650150002775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 650150002776 ABC-ATPase subunit interface; other site 650150002777 dimer interface [polypeptide binding]; other site 650150002778 putative PBP binding regions; other site 650150002779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002780 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 650150002781 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 650150002782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150002783 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150002784 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 650150002785 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 650150002786 IHF dimer interface [polypeptide binding]; other site 650150002787 IHF - DNA interface [nucleotide binding]; other site 650150002788 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 650150002789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150002790 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 650150002791 GTP-binding protein Der; Reviewed; Region: PRK00093 650150002792 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 650150002793 G1 box; other site 650150002794 GTP/Mg2+ binding site [chemical binding]; other site 650150002795 Switch I region; other site 650150002796 G2 box; other site 650150002797 Switch II region; other site 650150002798 G3 box; other site 650150002799 G4 box; other site 650150002800 G5 box; other site 650150002801 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 650150002802 G1 box; other site 650150002803 GTP/Mg2+ binding site [chemical binding]; other site 650150002804 Switch I region; other site 650150002805 G2 box; other site 650150002806 G3 box; other site 650150002807 Switch II region; other site 650150002808 G4 box; other site 650150002809 G5 box; other site 650150002810 cytidylate kinase; Provisional; Region: cmk; PRK00023 650150002811 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 650150002812 CMP-binding site; other site 650150002813 The sites determining sugar specificity; other site 650150002814 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 650150002815 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 650150002816 elongation factor P; Validated; Region: PRK00529 650150002817 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 650150002818 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 650150002819 RNA binding site [nucleotide binding]; other site 650150002820 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 650150002821 RNA binding site [nucleotide binding]; other site 650150002822 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 650150002823 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 650150002824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150002825 Walker A motif; other site 650150002826 ATP binding site [chemical binding]; other site 650150002827 Walker B motif; other site 650150002828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150002829 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 650150002830 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 650150002831 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150002832 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 650150002833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 650150002834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 650150002835 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 650150002836 ATP binding site [chemical binding]; other site 650150002837 putative Mg++ binding site [ion binding]; other site 650150002838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002839 nucleotide binding region [chemical binding]; other site 650150002840 ATP-binding site [chemical binding]; other site 650150002841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150002842 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 650150002843 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 650150002844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 650150002845 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 650150002846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 650150002847 DNA binding residues [nucleotide binding] 650150002848 DNA primase; Validated; Region: dnaG; PRK05667 650150002849 CHC2 zinc finger; Region: zf-CHC2; cl02597 650150002850 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 650150002851 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 650150002852 active site 650150002853 metal binding site [ion binding]; metal-binding site 650150002854 interdomain interaction site; other site 650150002855 glycyl-tRNA synthetase; Provisional; Region: PRK04173 650150002856 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150002857 motif 1; other site 650150002858 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 650150002859 active site 650150002860 motif 2; other site 650150002861 motif 3; other site 650150002862 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 650150002863 anticodon binding site; other site 650150002864 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 650150002865 Recombination protein O N terminal; Region: RecO_N; pfam11967 650150002866 Recombination protein O C terminal; Region: RecO_C; pfam02565 650150002867 GTPase Era; Reviewed; Region: era; PRK00089 650150002868 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 650150002869 G1 box; other site 650150002870 GTP/Mg2+ binding site [chemical binding]; other site 650150002871 Switch I region; other site 650150002872 G2 box; other site 650150002873 Switch II region; other site 650150002874 G3 box; other site 650150002875 G4 box; other site 650150002876 G5 box; other site 650150002877 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 650150002878 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 650150002879 active site 650150002880 catalytic motif [active] 650150002881 Zn binding site [ion binding]; other site 650150002882 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 650150002883 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 650150002884 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 650150002885 PhoU domain; Region: PhoU; pfam01895 650150002886 PhoU domain; Region: PhoU; pfam01895 650150002887 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 650150002888 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 650150002889 Walker A/P-loop; other site 650150002890 ATP binding site [chemical binding]; other site 650150002891 Q-loop/lid; other site 650150002892 ABC transporter signature motif; other site 650150002893 Walker B; other site 650150002894 D-loop; other site 650150002895 H-loop/switch region; other site 650150002896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150002897 dimer interface [polypeptide binding]; other site 650150002898 conserved gate region; other site 650150002899 putative PBP binding loops; other site 650150002900 ABC-ATPase subunit interface; other site 650150002901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150002902 dimer interface [polypeptide binding]; other site 650150002903 conserved gate region; other site 650150002904 putative PBP binding loops; other site 650150002905 ABC-ATPase subunit interface; other site 650150002906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150002907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150002908 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 650150002909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 650150002910 dimer interface [polypeptide binding]; other site 650150002911 phosphorylation site [posttranslational modification] 650150002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150002913 ATP binding site [chemical binding]; other site 650150002914 Mg2+ binding site [ion binding]; other site 650150002915 G-X-G motif; other site 650150002916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150002917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150002918 active site 650150002919 phosphorylation site [posttranslational modification] 650150002920 intermolecular recognition site; other site 650150002921 dimerization interface [polypeptide binding]; other site 650150002922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150002923 DNA binding site [nucleotide binding] 650150002924 PhoH-like protein; Region: PhoH; cl12134 650150002925 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 650150002926 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 650150002927 DEAD-like helicases superfamily; Region: DEXDc; smart00487 650150002928 ATP binding site [chemical binding]; other site 650150002929 Mg++ binding site [ion binding]; other site 650150002930 motif III; other site 650150002931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150002932 nucleotide binding region [chemical binding]; other site 650150002933 ATP-binding site [chemical binding]; other site 650150002934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150002935 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 650150002936 Walker A/P-loop; other site 650150002937 ATP binding site [chemical binding]; other site 650150002938 Q-loop/lid; other site 650150002939 ABC transporter signature motif; other site 650150002940 Walker B; other site 650150002941 D-loop; other site 650150002942 H-loop/switch region; other site 650150002943 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 650150002944 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 650150002945 intersubunit interface [polypeptide binding]; other site 650150002946 active site 650150002947 catalytic residue [active] 650150002948 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 650150002949 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 650150002950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150002951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150002952 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 650150002953 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150002954 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150002955 RNA binding surface [nucleotide binding]; other site 650150002956 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 650150002957 active site 650150002958 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 650150002959 ScpA/B protein; Region: ScpA_ScpB; cl00598 650150002960 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 650150002961 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 650150002962 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 650150002963 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 650150002964 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 650150002965 folate binding site [chemical binding]; other site 650150002966 NADP+ binding site [chemical binding]; other site 650150002967 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 650150002968 dimerization interface [polypeptide binding]; other site 650150002969 active site 650150002970 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 650150002971 generic binding surface II; other site 650150002972 generic binding surface I; other site 650150002973 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 650150002974 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 650150002975 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 650150002976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 650150002977 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 650150002978 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 650150002979 active site 650150002980 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150002981 TM-ABC transporter signature motif; other site 650150002982 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150002983 TM-ABC transporter signature motif; other site 650150002984 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 650150002985 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 650150002986 Walker A/P-loop; other site 650150002987 ATP binding site [chemical binding]; other site 650150002988 Q-loop/lid; other site 650150002989 ABC transporter signature motif; other site 650150002990 Walker B; other site 650150002991 D-loop; other site 650150002992 H-loop/switch region; other site 650150002993 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 650150002994 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150002995 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150002996 ligand binding site [chemical binding]; other site 650150002997 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150002998 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150002999 ligand binding site [chemical binding]; other site 650150003000 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 650150003001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 650150003002 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 650150003003 active site 650150003004 dimer interface [polypeptide binding]; other site 650150003005 motif 1; other site 650150003006 motif 2; other site 650150003007 motif 3; other site 650150003008 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 650150003009 anticodon binding site; other site 650150003010 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 650150003011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150003012 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150003013 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 650150003014 pyruvate kinase; Provisional; Region: PRK05826 650150003015 domain interfaces; other site 650150003016 active site 650150003017 6-phosphofructokinase; Provisional; Region: PRK03202 650150003018 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 650150003019 active site 650150003020 ADP/pyrophosphate binding site [chemical binding]; other site 650150003021 dimerization interface [polypeptide binding]; other site 650150003022 allosteric effector site; other site 650150003023 fructose-1,6-bisphosphate binding site; other site 650150003024 primosomal protein DnaI; Reviewed; Region: PRK08939 650150003025 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 650150003026 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 650150003027 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 650150003028 CoA-binding site [chemical binding]; other site 650150003029 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 650150003030 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 650150003031 DNA binding site [nucleotide binding] 650150003032 catalytic residue [active] 650150003033 H2TH interface [polypeptide binding]; other site 650150003034 putative catalytic residues [active] 650150003035 turnover-facilitating residue; other site 650150003036 intercalation triad [nucleotide binding]; other site 650150003037 8OG recognition residue [nucleotide binding]; other site 650150003038 putative reading head residues; other site 650150003039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 650150003040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 650150003041 DNA polymerase I; Provisional; Region: PRK05755 650150003042 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 650150003043 active site 650150003044 metal binding site 1 [ion binding]; metal-binding site 650150003045 putative 5' ssDNA interaction site; other site 650150003046 metal binding site 3; metal-binding site 650150003047 metal binding site 2 [ion binding]; metal-binding site 650150003048 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 650150003049 putative DNA binding site [nucleotide binding]; other site 650150003050 putative metal binding site [ion binding]; other site 650150003051 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 650150003052 active site 650150003053 substrate binding site [chemical binding]; other site 650150003054 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 650150003055 active site 650150003056 DNA binding site [nucleotide binding] 650150003057 catalytic site [active] 650150003058 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 650150003059 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 650150003060 intersubunit interface [polypeptide binding]; other site 650150003061 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 650150003062 Domain of unknown function DUF20; Region: UPF0118; cl00465 650150003063 rod shape-determining protein MreC; Provisional; Region: PRK13922 650150003064 rod shape-determining protein MreC; Region: MreC; pfam04085 650150003065 hypothetical protein; Reviewed; Region: PRK00024 650150003066 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 650150003067 MPN+ (JAMM) motif; other site 650150003068 Zinc-binding site [ion binding]; other site 650150003069 cell division protein FtsZ; Validated; Region: PRK09330 650150003070 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 650150003071 nucleotide binding site [chemical binding]; other site 650150003072 SulA interaction site; other site 650150003073 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 650150003074 Cell division protein FtsA; Region: FtsA; cl11496 650150003075 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 650150003076 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 650150003077 Thiamine pyrophosphokinase; Region: TPK; cd07995 650150003078 active site 650150003079 dimerization interface [polypeptide binding]; other site 650150003080 thiamine binding site [chemical binding]; other site 650150003081 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 650150003082 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 650150003083 substrate binding site [chemical binding]; other site 650150003084 hexamer interface [polypeptide binding]; other site 650150003085 metal binding site [ion binding]; metal-binding site 650150003086 GTPase RsgA; Reviewed; Region: PRK00098 650150003087 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 650150003088 GTPase/OB domain interface [polypeptide binding]; other site 650150003089 GTPase/Zn-binding domain interface [polypeptide binding]; other site 650150003090 GTP/Mg2+ binding site [chemical binding]; other site 650150003091 G4 box; other site 650150003092 G5 box; other site 650150003093 G1 box; other site 650150003094 Switch I region; other site 650150003095 G2 box; other site 650150003096 G3 box; other site 650150003097 Switch II region; other site 650150003098 Catalytic domain of Protein Kinases; Region: PKc; cd00180 650150003099 active site 650150003100 ATP binding site [chemical binding]; other site 650150003101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 650150003102 substrate binding site [chemical binding]; other site 650150003103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 650150003104 substrate binding site [chemical binding]; other site 650150003105 activation loop (A-loop); other site 650150003106 activation loop (A-loop); other site 650150003107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 650150003108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 650150003109 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 650150003110 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 650150003111 Active site [active] 650150003112 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 650150003113 16S rRNA methyltransferase B; Provisional; Region: PRK14902 650150003114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150003115 S-adenosylmethionine binding site [chemical binding]; other site 650150003116 primosome assembly protein PriA; Validated; Region: PRK05580 650150003117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150003118 ATP binding site [chemical binding]; other site 650150003119 putative Mg++ binding site [ion binding]; other site 650150003120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003121 nucleotide binding region [chemical binding]; other site 650150003122 ATP-binding site [chemical binding]; other site 650150003123 cytidylate kinase; Region: cmk; TIGR00017 650150003124 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 650150003125 catalytic site [active] 650150003126 G-X2-G-X-G-K; other site 650150003127 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 650150003128 Domain of unknown function (DUF814); Region: DUF814; pfam05670 650150003129 Protein of unknown function DUF45; Region: DUF45; cl00636 650150003130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150003131 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150003132 active site 650150003133 motif I; other site 650150003134 motif II; other site 650150003135 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 650150003136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 650150003137 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 650150003138 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 650150003139 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 650150003140 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 650150003141 ATP synthase subunit D; Region: ATP-synt_D; cl00613 650150003142 V-type ATP synthase subunit B; Provisional; Region: PRK04196 650150003143 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150003144 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135 650150003145 Walker A motif homologous position; other site 650150003146 Walker B motif; other site 650150003147 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150003148 V-type ATP synthase subunit A; Provisional; Region: PRK04192 650150003149 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 650150003150 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 650150003151 Walker A motif/ATP binding site; other site 650150003152 Walker B motif; other site 650150003153 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 650150003154 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 650150003155 V-type ATP synthase subunit I; Validated; Region: PRK05771 650150003156 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 650150003157 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660 650150003158 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 650150003159 active site 650150003160 ADP/pyrophosphate binding site [chemical binding]; other site 650150003161 allosteric effector site; other site 650150003162 dimerization interface [polypeptide binding]; other site 650150003163 fructose-1,6-bisphosphate binding site; other site 650150003164 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003165 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150003167 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003168 ABC transporter; Region: ABC_tran_2; pfam12848 650150003169 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003170 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 650150003171 active site 650150003172 metal binding site [ion binding]; metal-binding site 650150003173 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 650150003174 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 650150003175 putative dimer interface [polypeptide binding]; other site 650150003176 putative anticodon binding site; other site 650150003177 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 650150003178 homodimer interface [polypeptide binding]; other site 650150003179 motif 1; other site 650150003180 motif 2; other site 650150003181 active site 650150003182 motif 3; other site 650150003183 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 650150003184 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 650150003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150003186 UGMP family protein; Validated; Region: PRK09604 650150003187 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 650150003188 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 650150003189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150003190 Coenzyme A binding pocket [chemical binding]; other site 650150003191 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 650150003192 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 650150003193 Protein of unknown function (DUF402); Region: DUF402; cl00979 650150003194 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl01588 650150003195 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 650150003196 tetramer interfaces [polypeptide binding]; other site 650150003197 binuclear metal-binding site [ion binding]; other site 650150003198 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 650150003199 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 650150003200 active site 650150003201 Zn binding site [ion binding]; other site 650150003202 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 650150003203 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 650150003204 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 650150003205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003206 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 650150003207 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 650150003208 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 650150003209 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150003210 active site 650150003211 HIGH motif; other site 650150003212 nucleotide binding site [chemical binding]; other site 650150003213 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 650150003214 active site 650150003215 KMSKS motif; other site 650150003216 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 650150003217 tRNA binding surface [nucleotide binding]; other site 650150003218 anticodon binding site; other site 650150003219 DivIVA protein; Region: DivIVA; pfam05103 650150003220 Protein of unknown function (DUF552); Region: DUF552; cl00775 650150003221 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 650150003222 30S subunit binding site; other site 650150003223 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 650150003224 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 650150003225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150003226 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 650150003227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150003228 motif II; other site 650150003229 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 650150003230 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 650150003231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003233 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150003234 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150003235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150003236 Integrase core domain; Region: rve; cl01316 650150003237 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 650150003238 exonuclease SbcC; Region: sbcc; TIGR00618 650150003239 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 650150003240 Walker A/P-loop; other site 650150003241 ATP binding site [chemical binding]; other site 650150003242 Q-loop/lid; other site 650150003243 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 650150003244 Q-loop/lid; other site 650150003245 ABC transporter signature motif; other site 650150003246 Walker B; other site 650150003247 D-loop; other site 650150003248 H-loop/switch region; other site 650150003249 exonuclease subunit SbcD; Provisional; Region: PRK10966 650150003250 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 650150003251 active site 650150003252 metal binding site [ion binding]; metal-binding site 650150003253 DNA binding site [nucleotide binding] 650150003254 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 650150003255 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 650150003256 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 650150003257 active site 650150003258 catalytic residues [active] 650150003259 galactokinase; Provisional; Region: PRK05322 650150003260 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 650150003261 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 650150003262 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150003263 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 650150003264 TM-ABC transporter signature motif; other site 650150003265 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 650150003266 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 650150003267 Walker A/P-loop; other site 650150003268 ATP binding site [chemical binding]; other site 650150003269 Q-loop/lid; other site 650150003270 ABC transporter signature motif; other site 650150003271 Walker B; other site 650150003272 D-loop; other site 650150003273 H-loop/switch region; other site 650150003274 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 650150003275 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 650150003276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150003277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150003278 DNA binding site [nucleotide binding] 650150003279 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 650150003280 putative ligand binding site [chemical binding]; other site 650150003281 putative dimerization interface [polypeptide binding]; other site 650150003282 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 650150003283 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 650150003284 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150003285 active site 650150003286 HIGH motif; other site 650150003287 nucleotide binding site [chemical binding]; other site 650150003288 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 650150003289 active site 650150003290 KMSKS motif; other site 650150003291 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 650150003292 tRNA binding surface [nucleotide binding]; other site 650150003293 anticodon binding site; other site 650150003294 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 650150003295 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150003296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003297 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 650150003298 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 650150003299 G1 box; other site 650150003300 GTP/Mg2+ binding site [chemical binding]; other site 650150003301 Switch I region; other site 650150003302 G2 box; other site 650150003303 G3 box; other site 650150003304 Switch II region; other site 650150003305 G4 box; other site 650150003306 G5 box; other site 650150003307 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 650150003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150003309 Walker A motif; other site 650150003310 ATP binding site [chemical binding]; other site 650150003311 Walker B motif; other site 650150003312 arginine finger; other site 650150003313 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 650150003314 trigger factor; Provisional; Region: tig; PRK01490 650150003315 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 650150003316 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 650150003317 G5 domain; Region: G5; pfam07501 650150003318 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 650150003319 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 650150003320 active site 650150003321 metal binding site [ion binding]; metal-binding site 650150003322 homotetramer interface [polypeptide binding]; other site 650150003323 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 650150003324 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 650150003325 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 650150003326 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 650150003327 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 650150003328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150003329 Walker A/P-loop; other site 650150003330 ATP binding site [chemical binding]; other site 650150003331 Q-loop/lid; other site 650150003332 ABC transporter signature motif; other site 650150003333 Walker B; other site 650150003334 D-loop; other site 650150003335 H-loop/switch region; other site 650150003336 Smr domain; Region: Smr; cl02619 650150003337 Colicin V production protein; Region: Colicin_V; cl00567 650150003338 ribonuclease HIII; Provisional; Region: PRK00996 650150003339 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 650150003340 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 650150003341 RNA/DNA hybrid binding site [nucleotide binding]; other site 650150003342 active site 650150003343 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 650150003344 catalytic motif [active] 650150003345 Zn binding site [ion binding]; other site 650150003346 Rhomboid family; Region: Rhomboid; cl11446 650150003347 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 650150003348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150003349 RNA binding surface [nucleotide binding]; other site 650150003350 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 650150003351 active site 650150003352 lipoprotein signal peptidase; Provisional; Region: PRK14787 650150003353 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 650150003354 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 650150003355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150003356 substrate binding pocket [chemical binding]; other site 650150003357 Isochorismatase family; Region: Isochorismatase; pfam00857 650150003358 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 650150003359 catalytic triad [active] 650150003360 conserved cis-peptide bond; other site 650150003361 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 650150003362 MatE; Region: MatE; pfam01554 650150003363 MatE; Region: MatE; pfam01554 650150003364 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 650150003365 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150003366 Walker A/P-loop; other site 650150003367 ATP binding site [chemical binding]; other site 650150003368 Q-loop/lid; other site 650150003369 ABC transporter signature motif; other site 650150003370 Walker B; other site 650150003371 D-loop; other site 650150003372 H-loop/switch region; other site 650150003373 Putative cyclase; Region: Cyclase; cl00814 650150003374 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003375 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003376 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003377 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 650150003378 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 650150003379 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 650150003380 active site 650150003381 (T/H)XGH motif; other site 650150003382 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 650150003383 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 650150003384 active site 650150003385 P-loop; other site 650150003386 phosphorylation site [posttranslational modification] 650150003387 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 650150003388 Domain of unknown function DUF87; Region: DUF87; pfam01935 650150003389 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 650150003390 methionine cluster; other site 650150003391 active site 650150003392 phosphorylation site [posttranslational modification] 650150003393 metal binding site [ion binding]; metal-binding site 650150003394 Scramblase; Region: Scramblase; cl02043 650150003395 Domain of unknown function (DUF296); Region: DUF296; cl00720 650150003396 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 650150003397 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003398 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 650150003399 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 650150003400 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150003401 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003402 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003403 PhoU domain; Region: PhoU; pfam01895 650150003404 PhoU domain; Region: PhoU; pfam01895 650150003405 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 650150003406 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003407 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 650150003408 PhoU domain; Region: PhoU; pfam01895 650150003409 PhoU domain; Region: PhoU; pfam01895 650150003410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003411 Ferritin-like domain; Region: Ferritin; pfam00210 650150003412 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 650150003413 dimerization interface [polypeptide binding]; other site 650150003414 DPS ferroxidase diiron center [ion binding]; other site 650150003415 ion pore; other site 650150003416 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 650150003417 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 650150003418 23S rRNA interface [nucleotide binding]; other site 650150003419 L3 interface [polypeptide binding]; other site 650150003420 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 650150003421 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 650150003422 dimerization interface 3.5A [polypeptide binding]; other site 650150003423 active site 650150003424 Cobalt transport protein; Region: CbiQ; cl00463 650150003425 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 650150003426 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 650150003427 Walker A/P-loop; other site 650150003428 ATP binding site [chemical binding]; other site 650150003429 Q-loop/lid; other site 650150003430 ABC transporter signature motif; other site 650150003431 Walker B; other site 650150003432 D-loop; other site 650150003433 H-loop/switch region; other site 650150003434 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 650150003435 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 650150003436 Walker A/P-loop; other site 650150003437 ATP binding site [chemical binding]; other site 650150003438 Q-loop/lid; other site 650150003439 ABC transporter signature motif; other site 650150003440 Walker B; other site 650150003441 D-loop; other site 650150003442 H-loop/switch region; other site 650150003443 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 650150003444 peptidase T; Region: peptidase-T; TIGR01882 650150003445 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 650150003446 metal binding site [ion binding]; metal-binding site 650150003447 dimer interface [polypeptide binding]; other site 650150003448 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 650150003449 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 650150003450 active site 650150003451 metal binding site [ion binding]; metal-binding site 650150003452 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 650150003453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150003454 non-specific DNA binding site [nucleotide binding]; other site 650150003455 salt bridge; other site 650150003456 sequence-specific DNA binding site [nucleotide binding]; other site 650150003457 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 650150003458 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150003459 Uncharacterized conserved protein [Function unknown]; Region: COG3589 650150003460 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 650150003461 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150003462 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 650150003463 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 650150003464 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 650150003465 alphaNTD homodimer interface [polypeptide binding]; other site 650150003466 alphaNTD - beta interaction site [polypeptide binding]; other site 650150003467 alphaNTD - beta' interaction site [polypeptide binding]; other site 650150003468 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 650150003469 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 650150003470 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 650150003471 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 650150003472 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 650150003473 rRNA binding site [nucleotide binding]; other site 650150003474 predicted 30S ribosome binding site; other site 650150003475 methionine aminopeptidase; Reviewed; Region: PRK07281 650150003476 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 650150003477 active site 650150003478 adenylate kinase; Reviewed; Region: adk; PRK00279 650150003479 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 650150003480 AMP-binding site [chemical binding]; other site 650150003481 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 650150003482 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 650150003483 SecY translocase; Region: SecY; pfam00344 650150003484 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 650150003485 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 650150003486 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 650150003487 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 650150003488 5S rRNA interface [nucleotide binding]; other site 650150003489 L27 interface [polypeptide binding]; other site 650150003490 L5 interface [polypeptide binding]; other site 650150003491 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 650150003492 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 650150003493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 650150003494 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 650150003495 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 650150003496 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 650150003497 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 650150003498 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 650150003499 KOW motif; Region: KOW; cl00354 650150003500 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 650150003501 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 650150003502 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 650150003503 23S rRNA interface [nucleotide binding]; other site 650150003504 putative translocon interaction site; other site 650150003505 signal recognition particle (SRP54) interaction site; other site 650150003506 L23 interface [polypeptide binding]; other site 650150003507 trigger factor interaction site; other site 650150003508 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 650150003509 23S rRNA interface [nucleotide binding]; other site 650150003510 5S rRNA interface [nucleotide binding]; other site 650150003511 putative antibiotic binding site [chemical binding]; other site 650150003512 L25 interface [polypeptide binding]; other site 650150003513 L27 interface [polypeptide binding]; other site 650150003514 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 650150003515 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 650150003516 G-X-X-G motif; other site 650150003517 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 650150003518 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 650150003519 putative translocon binding site; other site 650150003520 protein-rRNA interface [nucleotide binding]; other site 650150003521 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 650150003522 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 650150003523 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 650150003524 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 650150003525 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 650150003526 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 650150003527 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 650150003528 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 650150003529 elongation factor Tu; Reviewed; Region: PRK00049 650150003530 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 650150003531 G1 box; other site 650150003532 GEF interaction site [polypeptide binding]; other site 650150003533 GTP/Mg2+ binding site [chemical binding]; other site 650150003534 Switch I region; other site 650150003535 G2 box; other site 650150003536 G3 box; other site 650150003537 Switch II region; other site 650150003538 G4 box; other site 650150003539 G5 box; other site 650150003540 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 650150003541 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 650150003542 Antibiotic Binding Site [chemical binding]; other site 650150003543 elongation factor G; Reviewed; Region: PRK00007 650150003544 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 650150003545 G1 box; other site 650150003546 putative GEF interaction site [polypeptide binding]; other site 650150003547 GTP/Mg2+ binding site [chemical binding]; other site 650150003548 Switch I region; other site 650150003549 G2 box; other site 650150003550 G3 box; other site 650150003551 Switch II region; other site 650150003552 G4 box; other site 650150003553 G5 box; other site 650150003554 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 650150003555 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 650150003556 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 650150003557 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 650150003558 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 650150003559 S17 interaction site [polypeptide binding]; other site 650150003560 S8 interaction site; other site 650150003561 16S rRNA interaction site [nucleotide binding]; other site 650150003562 streptomycin interaction site [chemical binding]; other site 650150003563 23S rRNA interaction site [nucleotide binding]; other site 650150003564 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 650150003565 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 650150003566 Domain of unknown function DUF20; Region: UPF0118; cl00465 650150003567 Staphylococcal nuclease homologues; Region: SNc; smart00318 650150003568 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 650150003569 Catalytic site; other site 650150003570 FtsX-like permease family; Region: FtsX; pfam02687 650150003571 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 650150003572 FtsX-like permease family; Region: FtsX; pfam02687 650150003573 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003574 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150003575 Walker A/P-loop; other site 650150003576 ATP binding site [chemical binding]; other site 650150003577 Q-loop/lid; other site 650150003578 ABC transporter signature motif; other site 650150003579 Walker B; other site 650150003580 D-loop; other site 650150003581 H-loop/switch region; other site 650150003582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150003583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150003584 ATP binding site [chemical binding]; other site 650150003585 Mg2+ binding site [ion binding]; other site 650150003586 G-X-G motif; other site 650150003587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150003588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150003589 active site 650150003590 phosphorylation site [posttranslational modification] 650150003591 intermolecular recognition site; other site 650150003592 dimerization interface [polypeptide binding]; other site 650150003593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150003594 DNA binding site [nucleotide binding] 650150003595 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 650150003596 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 650150003597 LexA repressor, pseudogene, truncated by frameshift mutation 650150003598 DNA polymerase IV; Reviewed; Region: PRK03103 650150003599 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 650150003600 active site 650150003601 DNA binding site [nucleotide binding] 650150003602 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 650150003603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150003604 ATP binding site [chemical binding]; other site 650150003605 Mg2+ binding site [ion binding]; other site 650150003606 G-X-G motif; other site 650150003607 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150003609 active site 650150003610 phosphorylation site [posttranslational modification] 650150003611 intermolecular recognition site; other site 650150003612 LytTr DNA-binding domain; Region: LytTR; cl04498 650150003613 Protein of unknown function DUF262; Region: DUF262; cl14890 650150003614 Predicted HKD family nuclease [DNA replication, recombination, and repair]; Region: COG3886 650150003615 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 650150003616 putative homodimer interface [polypeptide binding]; other site 650150003617 putative active site [active] 650150003618 catalytic site [active] 650150003619 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 650150003620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150003621 ATP binding site [chemical binding]; other site 650150003622 putative Mg++ binding site [ion binding]; other site 650150003623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150003624 nucleotide binding region [chemical binding]; other site 650150003625 ATP-binding site [chemical binding]; other site 650150003626 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 650150003627 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 650150003628 HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 650150003629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003631 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150003632 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 650150003633 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 650150003634 oligoendopeptidase F; Region: pepF; TIGR00181 650150003635 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 650150003636 active site 650150003637 Zn binding site [ion binding]; other site 650150003638 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 650150003639 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 650150003640 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 650150003641 active site 650150003642 dimer interface [polypeptide binding]; other site 650150003643 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 650150003644 active site 650150003645 trimer interface [polypeptide binding]; other site 650150003646 allosteric site; other site 650150003647 active site lid [active] 650150003648 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 650150003649 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 650150003650 PhnA protein; Region: PhnA; pfam03831 650150003651 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 650150003652 active pocket/dimerization site; other site 650150003653 active site 650150003654 phosphorylation site [posttranslational modification] 650150003655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003656 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150003657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003658 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 650150003659 substrate binding site [chemical binding]; other site 650150003660 catalytic residues [active] 650150003661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150003662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150003663 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 650150003664 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 650150003665 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150003666 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150003667 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 650150003668 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 650150003669 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150003670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150003671 DNA binding site [nucleotide binding] 650150003672 domain linker motif; other site 650150003673 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 650150003674 putative dimerization interface [polypeptide binding]; other site 650150003675 putative ligand binding site [chemical binding]; other site 650150003676 Heparinase II/III-like protein; Region: Hepar_II_III; cl02215 650150003677 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 650150003678 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 650150003679 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 650150003680 active site 650150003681 phosphorylation site [posttranslational modification] 650150003682 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 650150003683 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 650150003684 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 650150003685 active site 650150003686 intersubunit interface [polypeptide binding]; other site 650150003687 catalytic residue [active] 650150003688 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 650150003689 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 650150003690 substrate binding site [chemical binding]; other site 650150003691 ATP binding site [chemical binding]; other site 650150003692 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 650150003693 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 650150003694 NADP binding site [chemical binding]; other site 650150003695 homodimer interface [polypeptide binding]; other site 650150003696 active site 650150003697 hypothetical protein; Provisional; Region: PRK09273 650150003698 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 650150003699 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 650150003700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150003701 flavoprotein, HI0933 family; Region: TIGR00275 650150003702 aspartate aminotransferase; Provisional; Region: PRK08361 650150003703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150003704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150003705 homodimer interface [polypeptide binding]; other site 650150003706 catalytic residue [active] 650150003707 VanZ like family; Region: VanZ; cl01971 650150003708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150003709 Coenzyme A binding pocket [chemical binding]; other site 650150003710 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 650150003711 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 650150003712 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 650150003713 putative active site cavity [active] 650150003714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 650150003715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150003716 dimer interface [polypeptide binding]; other site 650150003717 conserved gate region; other site 650150003718 putative PBP binding loops; other site 650150003719 ABC-ATPase subunit interface; other site 650150003720 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150003722 dimer interface [polypeptide binding]; other site 650150003723 conserved gate region; other site 650150003724 putative PBP binding loops; other site 650150003725 ABC-ATPase subunit interface; other site 650150003726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150003727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150003728 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150003729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 650150003730 putative active site [active] 650150003731 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 650150003732 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 650150003733 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 650150003734 N-acetylneuraminate lyase; Region: nanA; TIGR00683 650150003735 inhibitor site; inhibition site 650150003736 active site 650150003737 dimer interface [polypeptide binding]; other site 650150003738 catalytic residue [active] 650150003739 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 650150003740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150003741 motif II; other site 650150003742 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 650150003743 MatE; Region: MatE; pfam01554 650150003744 MatE; Region: MatE; pfam01554 650150003745 Putative esterase; Region: Esterase; pfam00756 650150003746 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150003747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150003748 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 650150003749 putative deacylase active site [active] 650150003750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003751 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 650150003752 MatE; Region: MatE; pfam01554 650150003753 MatE; Region: MatE; pfam01554 650150003754 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 650150003755 putative deacylase active site [active] 650150003756 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 650150003757 LytTr DNA-binding domain; Region: LytTR; cl04498 650150003758 Alkylmercury lyase; Region: MerB; pfam03243 650150003759 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 650150003760 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150003761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003762 Walker A/P-loop; other site 650150003763 ATP binding site [chemical binding]; other site 650150003764 Q-loop/lid; other site 650150003765 ABC transporter signature motif; other site 650150003766 Walker B; other site 650150003767 D-loop; other site 650150003768 H-loop/switch region; other site 650150003769 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 650150003770 oligomerisation interface [polypeptide binding]; other site 650150003771 mobile loop; other site 650150003772 roof hairpin; other site 650150003773 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 650150003774 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 650150003775 ring oligomerisation interface [polypeptide binding]; other site 650150003776 ATP/Mg binding site [chemical binding]; other site 650150003777 stacking interactions; other site 650150003778 hinge regions; other site 650150003779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150003780 non-specific DNA binding site [nucleotide binding]; other site 650150003781 salt bridge; other site 650150003782 sequence-specific DNA binding site [nucleotide binding]; other site 650150003783 transposase, pseudogene, truncated by premature stop codon 650150003784 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150003785 proteasome-activating nucleotidase; Provisional; Region: PRK03992 650150003786 putative transposase OrfB; Reviewed; Region: PHA02517 650150003787 Integrase core domain; Region: rve; cl01316 650150003788 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150003789 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 650150003790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 650150003791 ligand binding site [chemical binding]; other site 650150003792 flexible hinge region; other site 650150003793 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 650150003794 putative switch regulator; other site 650150003795 non-specific DNA interactions [nucleotide binding]; other site 650150003796 DNA binding site [nucleotide binding] 650150003797 sequence specific DNA binding site [nucleotide binding]; other site 650150003798 putative cAMP binding site [chemical binding]; other site 650150003799 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150003800 metal-binding site [ion binding] 650150003801 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 650150003802 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 650150003803 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003805 Integrase core domain; Region: rve; cl01316 650150003806 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 650150003807 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 650150003808 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 650150003809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 650150003810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150003811 non-specific DNA binding site [nucleotide binding]; other site 650150003812 salt bridge; other site 650150003813 sequence-specific DNA binding site [nucleotide binding]; other site 650150003814 Putative viral replication protein; Region: Viral_Rep; pfam02407 650150003815 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cl00322 650150003816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150003817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150003818 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 650150003819 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 650150003820 Int/Topo IB signature motif; other site 650150003821 GMP synthase; Reviewed; Region: guaA; PRK00074 650150003822 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 650150003823 AMP/PPi binding site [chemical binding]; other site 650150003824 candidate oxyanion hole; other site 650150003825 catalytic triad [active] 650150003826 potential glutamine specificity residues [chemical binding]; other site 650150003827 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 650150003828 ATP Binding subdomain [chemical binding]; other site 650150003829 Ligand Binding sites [chemical binding]; other site 650150003830 Dimerization subdomain; other site 650150003831 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 650150003832 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 650150003833 active site 650150003834 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 650150003835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150003836 active site 650150003837 motif I; other site 650150003838 motif II; other site 650150003839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003840 ornithine cyclodeaminase; Validated; Region: PRK08618 650150003841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150003842 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 650150003843 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 650150003844 Predicted transcriptional regulators [Transcription]; Region: COG1378 650150003845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150003846 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 650150003847 C-terminal domain interface [polypeptide binding]; other site 650150003848 sugar binding site [chemical binding]; other site 650150003849 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 650150003850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150003851 metal-binding site [ion binding] 650150003852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 650150003855 dimerization interface [polypeptide binding]; other site 650150003856 putative DNA binding site [nucleotide binding]; other site 650150003857 putative Zn2+ binding site [ion binding]; other site 650150003858 Restriction endonuclease; Region: Mrr_cat; cl00747 650150003859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150003860 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 650150003861 active site 650150003862 motif I; other site 650150003863 motif II; other site 650150003864 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 650150003865 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 650150003866 catalytic triad [active] 650150003867 active site nucleophile [active] 650150003868 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 650150003869 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 650150003870 putative oligomer interface [polypeptide binding]; other site 650150003871 putative active site [active] 650150003872 metal binding site [ion binding]; metal-binding site 650150003873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 650150003875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 650150003876 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 650150003877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150003878 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 650150003879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150003880 active site 650150003881 phosphorylation site [posttranslational modification] 650150003882 intermolecular recognition site; other site 650150003883 dimerization interface [polypeptide binding]; other site 650150003884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003885 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150003886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150003887 Protein of unknown function DUF124; Region: DUF124; cl00884 650150003888 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 650150003889 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 650150003890 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 650150003891 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 650150003892 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 650150003893 putative L-serine binding site [chemical binding]; other site 650150003894 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 650150003895 homotrimer interaction site [polypeptide binding]; other site 650150003896 putative active site [active] 650150003897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 650150003898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150003899 homodimer interface [polypeptide binding]; other site 650150003900 catalytic residue [active] 650150003901 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 650150003902 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 650150003903 putative active site [active] 650150003904 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150003905 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 650150003906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150003907 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 650150003908 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 650150003909 DNA binding residues [nucleotide binding] 650150003910 drug binding residues [chemical binding]; other site 650150003911 dimer interface [polypeptide binding]; other site 650150003912 Protein of unknown function (DUF541); Region: SIMPL; cl01077 650150003913 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 650150003914 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150003915 Sulfate transporter family; Region: Sulfate_transp; cl00967 650150003916 enolase; Provisional; Region: eno; PRK00077 650150003917 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 650150003918 dimer interface [polypeptide binding]; other site 650150003919 metal binding site [ion binding]; metal-binding site 650150003920 substrate binding pocket [chemical binding]; other site 650150003921 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 650150003922 substrate binding site [chemical binding]; other site 650150003923 dimer interface [polypeptide binding]; other site 650150003924 catalytic triad [active] 650150003925 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 650150003926 substrate binding site [chemical binding]; other site 650150003927 hinge regions; other site 650150003928 ADP binding site [chemical binding]; other site 650150003929 catalytic site [active] 650150003930 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 650150003931 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150003932 metal-binding site [ion binding] 650150003933 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 650150003934 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 650150003935 metal-binding site [ion binding] 650150003936 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150003937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150003938 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 650150003939 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 650150003940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150003941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150003942 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 650150003943 putative transposase OrfB; Reviewed; Region: PHA02517 650150003944 Integrase core domain; Region: rve; cl01316 650150003945 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 650150003946 active site 650150003947 tetramer interface [polypeptide binding]; other site 650150003948 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 650150003949 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 650150003950 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 650150003951 putative catalytic cysteine [active] 650150003952 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 650150003953 putative active site [active] 650150003954 metal binding site [ion binding]; metal-binding site 650150003955 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 650150003956 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 650150003957 active site 650150003958 catalytic residues [active] 650150003959 OsmC-like protein; Region: OsmC; cl00767 650150003960 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003961 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 650150003962 Walker A/P-loop; other site 650150003963 ATP binding site [chemical binding]; other site 650150003964 Q-loop/lid; other site 650150003965 ABC transporter signature motif; other site 650150003966 Walker B; other site 650150003967 D-loop; other site 650150003968 H-loop/switch region; other site 650150003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150003970 dimer interface [polypeptide binding]; other site 650150003971 conserved gate region; other site 650150003972 ABC-ATPase subunit interface; other site 650150003973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150003974 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 650150003975 motif 1; other site 650150003976 dimer interface [polypeptide binding]; other site 650150003977 active site 650150003978 motif 2; other site 650150003979 motif 3; other site 650150003980 YibE/F-like protein; Region: YibE_F; cl02259 650150003981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150003982 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150003983 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 650150003984 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 650150003985 metal binding site [ion binding]; metal-binding site 650150003986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150003987 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150003988 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 650150003989 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 650150003990 FtsX-like permease family; Region: FtsX; pfam02687 650150003991 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150003992 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150003993 Walker A/P-loop; other site 650150003994 ATP binding site [chemical binding]; other site 650150003995 Q-loop/lid; other site 650150003996 ABC transporter signature motif; other site 650150003997 Walker B; other site 650150003998 D-loop; other site 650150003999 H-loop/switch region; other site 650150004000 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 650150004001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 650150004002 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 650150004003 pyruvate phosphate dikinase; Provisional; Region: PRK09279 650150004004 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 650150004005 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 650150004006 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 650150004007 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 650150004008 UDP-glucose 4-epimerase; Region: PLN02240 650150004009 NAD binding site [chemical binding]; other site 650150004010 homodimer interface [polypeptide binding]; other site 650150004011 active site 650150004012 substrate binding site [chemical binding]; other site 650150004013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 650150004014 ABC-ATPase subunit interface; other site 650150004015 dimer interface [polypeptide binding]; other site 650150004016 putative PBP binding regions; other site 650150004017 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 650150004018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 650150004019 ABC-ATPase subunit interface; other site 650150004020 dimer interface [polypeptide binding]; other site 650150004021 putative PBP binding regions; other site 650150004022 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 650150004023 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 650150004024 Walker A/P-loop; other site 650150004025 ATP binding site [chemical binding]; other site 650150004026 Q-loop/lid; other site 650150004027 ABC transporter signature motif; other site 650150004028 Walker B; other site 650150004029 D-loop; other site 650150004030 H-loop/switch region; other site 650150004031 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 650150004032 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 650150004033 putative ligand binding residues [chemical binding]; other site 650150004034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004036 Walker A/P-loop; other site 650150004037 ATP binding site [chemical binding]; other site 650150004038 Q-loop/lid; other site 650150004039 ABC transporter signature motif; other site 650150004040 Walker B; other site 650150004041 D-loop; other site 650150004042 H-loop/switch region; other site 650150004043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 650150004044 dimerization interface [polypeptide binding]; other site 650150004045 putative DNA binding site [nucleotide binding]; other site 650150004046 putative Zn2+ binding site [ion binding]; other site 650150004047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004048 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150004049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004050 Walker A/P-loop; other site 650150004051 ATP binding site [chemical binding]; other site 650150004052 Q-loop/lid; other site 650150004053 ABC transporter signature motif; other site 650150004054 Walker B; other site 650150004055 D-loop; other site 650150004056 H-loop/switch region; other site 650150004057 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004058 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150004059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004060 Walker A/P-loop; other site 650150004061 ATP binding site [chemical binding]; other site 650150004062 Q-loop/lid; other site 650150004063 ABC transporter signature motif; other site 650150004064 Walker B; other site 650150004065 D-loop; other site 650150004066 H-loop/switch region; other site 650150004067 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 650150004068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 650150004069 RNA binding surface [nucleotide binding]; other site 650150004070 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 650150004071 active site 650150004072 uracil binding [chemical binding]; other site 650150004073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150004074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004075 Walker A/P-loop; other site 650150004076 ATP binding site [chemical binding]; other site 650150004077 Q-loop/lid; other site 650150004078 ABC transporter signature motif; other site 650150004079 Walker B; other site 650150004080 D-loop; other site 650150004081 H-loop/switch region; other site 650150004082 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150004083 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 650150004084 Walker A/P-loop; other site 650150004085 ATP binding site [chemical binding]; other site 650150004086 Q-loop/lid; other site 650150004087 ABC transporter signature motif; other site 650150004088 Walker B; other site 650150004089 D-loop; other site 650150004090 H-loop/switch region; other site 650150004091 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 650150004092 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 650150004093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150004094 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004096 Walker A/P-loop; other site 650150004097 ATP binding site [chemical binding]; other site 650150004098 Q-loop/lid; other site 650150004099 ABC transporter signature motif; other site 650150004100 Walker B; other site 650150004101 D-loop; other site 650150004102 H-loop/switch region; other site 650150004103 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 650150004104 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 650150004105 putative active site [active] 650150004106 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 650150004107 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 650150004108 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 650150004109 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 650150004110 active site 650150004111 phosphorylation site [posttranslational modification] 650150004112 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 650150004113 active pocket/dimerization site; other site 650150004114 active site 650150004115 phosphorylation site [posttranslational modification] 650150004116 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 650150004117 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 650150004118 DNA interaction; other site 650150004119 Metal-binding active site; metal-binding site 650150004120 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 650150004121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150004122 Walker A motif; other site 650150004123 ATP binding site [chemical binding]; other site 650150004124 Walker B motif; other site 650150004125 arginine finger; other site 650150004126 Transcriptional antiterminator [Transcription]; Region: COG3933 650150004127 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 650150004128 active pocket/dimerization site; other site 650150004129 active site 650150004130 phosphorylation site [posttranslational modification] 650150004131 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 650150004132 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150004133 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 650150004134 active site turn [active] 650150004135 phosphorylation site [posttranslational modification] 650150004136 transcriptional antiterminator BglG; Provisional; Region: PRK09772 650150004137 CAT RNA binding domain; Region: CAT_RBD; pfam03123 650150004138 PRD domain; Region: PRD; pfam00874 650150004139 PRD domain; Region: PRD; pfam00874 650150004140 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 650150004141 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 650150004142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 650150004143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150004144 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 650150004145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 650150004148 dimerization interface [polypeptide binding]; other site 650150004149 Acetokinase family; Region: Acetate_kinase; cl01029 650150004150 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 650150004151 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 650150004152 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 650150004153 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 650150004154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150004155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150004156 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 650150004157 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 650150004158 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 650150004159 E3 interaction surface; other site 650150004160 lipoyl attachment site [posttranslational modification]; other site 650150004161 e3 binding domain; Region: E3_binding; pfam02817 650150004162 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 650150004163 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 650150004164 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 650150004165 alpha subunit interface [polypeptide binding]; other site 650150004166 TPP binding site [chemical binding]; other site 650150004167 heterodimer interface [polypeptide binding]; other site 650150004168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150004169 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 650150004170 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 650150004171 TPP-binding site [chemical binding]; other site 650150004172 tetramer interface [polypeptide binding]; other site 650150004173 heterodimer interface [polypeptide binding]; other site 650150004174 phosphorylation loop region [posttranslational modification] 650150004175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004176 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150004177 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 650150004178 Walker A/P-loop; other site 650150004179 ATP binding site [chemical binding]; other site 650150004180 Q-loop/lid; other site 650150004181 ABC transporter signature motif; other site 650150004182 Walker B; other site 650150004183 D-loop; other site 650150004184 H-loop/switch region; other site 650150004185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 650150004186 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 650150004187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004188 Walker A/P-loop; other site 650150004189 ATP binding site [chemical binding]; other site 650150004190 Q-loop/lid; other site 650150004191 ABC transporter signature motif; other site 650150004192 Walker B; other site 650150004193 D-loop; other site 650150004194 H-loop/switch region; other site 650150004195 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 650150004196 DNA binding residues [nucleotide binding] 650150004197 dimer interface [polypeptide binding]; other site 650150004198 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 650150004199 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150004201 Integrase core domain; Region: rve; cl01316 650150004202 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150004203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150004204 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150004205 Predicted membrane protein [Function unknown]; Region: COG1288 650150004206 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150004207 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 650150004208 hypothetical protein; Provisional; Region: PRK07205 650150004209 active site 650150004210 metal binding site [ion binding]; metal-binding site 650150004211 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 650150004212 nudix motif; other site 650150004213 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 650150004214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004217 dimerization interface [polypeptide binding]; other site 650150004218 YceG-like family; Region: YceG; pfam02618 650150004219 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 650150004220 dimerization interface [polypeptide binding]; other site 650150004221 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 650150004222 CPxP motif; other site 650150004223 Domain of unknown function (DUF386); Region: DUF386; cl01047 650150004224 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 650150004225 Acyltransferase family; Region: Acyl_transf_3; pfam01757 650150004226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150004227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150004228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150004229 active site 650150004230 phosphorylation site [posttranslational modification] 650150004231 intermolecular recognition site; other site 650150004232 dimerization interface [polypeptide binding]; other site 650150004233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150004234 DNA binding site [nucleotide binding] 650150004235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150004236 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 650150004237 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 650150004238 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 650150004239 Ligand Binding Site [chemical binding]; other site 650150004240 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 650150004241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 650150004242 FeS/SAM binding site; other site 650150004243 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150004244 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 650150004245 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150004246 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150004247 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150004248 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150004249 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 650150004250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150004251 Membrane transport protein; Region: Mem_trans; cl09117 650150004252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 650150004253 active site 650150004254 nucleotide binding site [chemical binding]; other site 650150004255 HIGH motif; other site 650150004256 KMSKS motif; other site 650150004257 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 650150004258 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 650150004259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 650150004260 active site 650150004261 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 650150004262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 650150004263 putative ADP-binding pocket [chemical binding]; other site 650150004264 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 650150004265 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 650150004266 Bacterial sugar transferase; Region: Bac_transf; cl00939 650150004267 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 650150004268 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 650150004269 inhibitor-cofactor binding pocket; inhibition site 650150004270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 650150004271 catalytic residue [active] 650150004272 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 650150004273 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 650150004274 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 650150004275 NAD(P) binding site [chemical binding]; other site 650150004276 homodimer interface [polypeptide binding]; other site 650150004277 substrate binding site [chemical binding]; other site 650150004278 active site 650150004279 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 650150004280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004281 non-specific DNA binding site [nucleotide binding]; other site 650150004282 salt bridge; other site 650150004283 sequence-specific DNA binding site [nucleotide binding]; other site 650150004284 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 650150004285 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 650150004286 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004287 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150004288 Walker A/P-loop; other site 650150004289 ATP binding site [chemical binding]; other site 650150004290 Q-loop/lid; other site 650150004291 ABC transporter signature motif; other site 650150004292 Walker B; other site 650150004293 D-loop; other site 650150004294 H-loop/switch region; other site 650150004295 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 650150004296 FtsX-like permease family; Region: FtsX; pfam02687 650150004297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 650150004298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 650150004299 Integrase core domain; Region: rve; cl01316 650150004300 gamma-glutamyl kinase; Provisional; Region: PRK05429 650150004301 putative transposase OrfB; Reviewed; Region: PHA02517 650150004302 Protein of unknown function (DUF421); Region: DUF421; cl00990 650150004303 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 650150004304 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 650150004305 putative transposase OrfB; Reviewed; Region: PHA02517 650150004306 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 650150004307 active site 650150004308 Predicted membrane protein [Function unknown]; Region: COG2364 650150004309 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 650150004310 active site 650150004311 tetramer interface [polypeptide binding]; other site 650150004312 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150004313 TM-ABC transporter signature motif; other site 650150004314 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 650150004315 TM-ABC transporter signature motif; other site 650150004316 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 650150004317 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 650150004318 Walker A/P-loop; other site 650150004319 ATP binding site [chemical binding]; other site 650150004320 Q-loop/lid; other site 650150004321 ABC transporter signature motif; other site 650150004322 Walker B; other site 650150004323 D-loop; other site 650150004324 H-loop/switch region; other site 650150004325 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 650150004326 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 650150004327 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 650150004328 ligand binding site [chemical binding]; other site 650150004329 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 650150004330 substrate binding site [chemical binding]; other site 650150004331 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 650150004332 dimer interface [polypeptide binding]; other site 650150004333 ATP binding site [chemical binding]; other site 650150004334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 650150004335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 650150004336 DNA binding site [nucleotide binding] 650150004337 domain linker motif; other site 650150004338 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 650150004339 ligand binding site [chemical binding]; other site 650150004340 dimerization interface [polypeptide binding]; other site 650150004341 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004342 potential frameshift: common BLAST hit: gi|49484823|ref|YP_042047.1| transposase 650150004343 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004344 Integrase core domain; Region: rve; cl01316 650150004345 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 650150004346 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 650150004347 active site 650150004348 ATP binding site [chemical binding]; other site 650150004349 substrate binding site [chemical binding]; other site 650150004350 dimer interface [polypeptide binding]; other site 650150004351 FtsX-like permease family; Region: FtsX; pfam02687 650150004352 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 650150004353 FtsX-like permease family; Region: FtsX; pfam02687 650150004354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 650150004355 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 650150004356 Walker A/P-loop; other site 650150004357 ATP binding site [chemical binding]; other site 650150004358 Q-loop/lid; other site 650150004359 ABC transporter signature motif; other site 650150004360 Walker B; other site 650150004361 D-loop; other site 650150004362 H-loop/switch region; other site 650150004363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 650150004364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 650150004365 phosphorylation site [posttranslational modification] 650150004366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 650150004367 ATP binding site [chemical binding]; other site 650150004368 Mg2+ binding site [ion binding]; other site 650150004369 G-X-G motif; other site 650150004370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 650150004371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 650150004372 active site 650150004373 phosphorylation site [posttranslational modification] 650150004374 intermolecular recognition site; other site 650150004375 dimerization interface [polypeptide binding]; other site 650150004376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 650150004377 DNA binding site [nucleotide binding] 650150004378 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 650150004379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004381 dimer interface [polypeptide binding]; other site 650150004382 conserved gate region; other site 650150004383 putative PBP binding loops; other site 650150004384 ABC-ATPase subunit interface; other site 650150004385 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 650150004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004387 dimer interface [polypeptide binding]; other site 650150004388 conserved gate region; other site 650150004389 putative PBP binding loops; other site 650150004390 ABC-ATPase subunit interface; other site 650150004391 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 650150004392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004393 Walker A/P-loop; other site 650150004394 ATP binding site [chemical binding]; other site 650150004395 Q-loop/lid; other site 650150004396 ABC transporter signature motif; other site 650150004397 Walker B; other site 650150004398 D-loop; other site 650150004399 H-loop/switch region; other site 650150004400 TOBE domain; Region: TOBE_2; cl01440 650150004401 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 650150004402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150004403 non-specific DNA binding site [nucleotide binding]; other site 650150004404 salt bridge; other site 650150004405 sequence-specific DNA binding site [nucleotide binding]; other site 650150004406 Cupin domain; Region: Cupin_2; cl09118 650150004407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 650150004408 catalytic residues [active] 650150004409 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 650150004410 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 650150004411 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 650150004412 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 650150004413 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 650150004414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 650150004415 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 650150004416 active site 650150004417 metal binding site [ion binding]; metal-binding site 650150004418 homotetramer interface [polypeptide binding]; other site 650150004419 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 650150004420 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 650150004421 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150004422 Walker A/P-loop; other site 650150004423 ATP binding site [chemical binding]; other site 650150004424 Q-loop/lid; other site 650150004425 ABC transporter signature motif; other site 650150004426 Walker B; other site 650150004427 D-loop; other site 650150004428 H-loop/switch region; other site 650150004429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150004430 DNA-binding site [nucleotide binding]; DNA binding site 650150004431 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 650150004432 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 650150004433 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 650150004434 active site 650150004435 HIGH motif; other site 650150004436 KMSK motif region; other site 650150004437 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 650150004438 tRNA binding surface [nucleotide binding]; other site 650150004439 anticodon binding site; other site 650150004440 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 650150004441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 650150004444 dimerization interface [polypeptide binding]; other site 650150004445 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 650150004446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 650150004447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 650150004448 catalytic residue [active] 650150004449 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 650150004450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 650150004451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 650150004452 substrate binding pocket [chemical binding]; other site 650150004453 membrane-bound complex binding site; other site 650150004454 hinge residues; other site 650150004455 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 650150004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004457 dimer interface [polypeptide binding]; other site 650150004458 conserved gate region; other site 650150004459 putative PBP binding loops; other site 650150004460 ABC-ATPase subunit interface; other site 650150004461 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 650150004462 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 650150004463 Walker A/P-loop; other site 650150004464 ATP binding site [chemical binding]; other site 650150004465 Q-loop/lid; other site 650150004466 ABC transporter signature motif; other site 650150004467 Walker B; other site 650150004468 D-loop; other site 650150004469 H-loop/switch region; other site 650150004470 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 650150004471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 650150004472 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 650150004473 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 650150004474 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 650150004475 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 650150004476 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 650150004477 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 650150004478 homotetramer interface [polypeptide binding]; other site 650150004479 FMN binding site [chemical binding]; other site 650150004480 homodimer contacts [polypeptide binding]; other site 650150004481 putative active site [active] 650150004482 putative substrate binding site [chemical binding]; other site 650150004483 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 650150004484 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 650150004485 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150004486 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 650150004487 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 650150004488 mevalonate kinase; Region: mevalon_kin; TIGR00549 650150004489 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 650150004490 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150004491 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 650150004492 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 650150004493 putative homodimer interface [polypeptide binding]; other site 650150004494 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 650150004495 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 650150004496 RNA polymerase factor sigma-70; Validated; Region: PRK08295 650150004497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 650150004498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 650150004499 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 650150004500 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 650150004501 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 650150004502 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258 650150004503 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 650150004504 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 650150004505 active site 650150004506 HIGH motif; other site 650150004507 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 650150004508 KMSKS motif; other site 650150004509 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 650150004510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150004511 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 650150004512 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 650150004513 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 650150004514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 650150004515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 650150004516 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 650150004517 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 650150004518 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 650150004519 phosphate binding site [ion binding]; other site 650150004520 putative substrate binding pocket [chemical binding]; other site 650150004521 dimer interface [polypeptide binding]; other site 650150004522 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 650150004523 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 650150004524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150004525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 650150004526 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 650150004527 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 650150004528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 650150004529 motif II; other site 650150004530 HPr kinase/phosphorylase; Provisional; Region: PRK05428 650150004531 DRTGG domain; Region: DRTGG; cl12147 650150004532 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 650150004533 Hpr binding site; other site 650150004534 active site 650150004535 homohexamer subunit interaction site [polypeptide binding]; other site 650150004536 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 650150004537 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 650150004538 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 650150004539 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 650150004540 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 650150004541 excinuclease ABC subunit B; Provisional; Region: PRK05298 650150004542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150004543 ATP binding site [chemical binding]; other site 650150004544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004545 nucleotide binding region [chemical binding]; other site 650150004546 ATP-binding site [chemical binding]; other site 650150004547 Ultra-violet resistance protein B; Region: UvrB; pfam12344 650150004548 UvrB/uvrC motif; Region: UVR; pfam02151 650150004549 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 650150004550 C-terminal peptidase (prc); Region: prc; TIGR00225 650150004551 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 650150004552 protein binding site [polypeptide binding]; other site 650150004553 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 650150004554 Catalytic dyad [active] 650150004555 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 650150004556 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 650150004557 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 650150004558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 650150004559 Integrase core domain; Region: rve; cl01316 650150004560 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 650150004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150004562 Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211 650150004563 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004564 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 650150004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 650150004566 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004567 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 650150004568 FtsX-like permease family; Region: FtsX; pfam02687 650150004569 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 650150004570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150004571 Walker A/P-loop; other site 650150004572 ATP binding site [chemical binding]; other site 650150004573 Q-loop/lid; other site 650150004574 ABC transporter signature motif; other site 650150004575 Walker B; other site 650150004576 D-loop; other site 650150004577 H-loop/switch region; other site 650150004578 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 650150004579 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 650150004580 peptide chain release factor 2; Validated; Region: prfB; PRK00578 650150004581 RF-1 domain; Region: RF-1; cl02875 650150004582 RF-1 domain; Region: RF-1; cl02875 650150004583 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 650150004584 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 650150004585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004586 nucleotide binding region [chemical binding]; other site 650150004587 ATP-binding site [chemical binding]; other site 650150004588 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 650150004589 DNA-binding site [nucleotide binding]; DNA binding site 650150004590 RNA-binding motif; other site 650150004591 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 650150004592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150004593 ATP binding site [chemical binding]; other site 650150004594 putative Mg++ binding site [ion binding]; other site 650150004595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004596 nucleotide binding region [chemical binding]; other site 650150004597 ATP-binding site [chemical binding]; other site 650150004598 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 650150004599 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 650150004600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 650150004601 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 650150004602 active site 650150004603 substrate binding site [chemical binding]; other site 650150004604 catalytic site [active] 650150004605 heat shock protein 90; Provisional; Region: PRK05218 650150004606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 650150004607 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 650150004608 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 650150004609 Cl- selectivity filter; other site 650150004610 Cl- binding residues [ion binding]; other site 650150004611 pore gating glutamate residue; other site 650150004612 dimer interface [polypeptide binding]; other site 650150004613 H+/Cl- coupling transport residue; other site 650150004614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 650150004615 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 650150004616 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 650150004617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004618 3H domain; Region: 3H; pfam02829 650150004619 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 650150004620 putative ArsC-like catalytic residues; other site 650150004621 putative TRX-like catalytic residues [active] 650150004622 Protein of unknown function (DUF328); Region: DUF328; cl01143 650150004623 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 650150004624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150004625 NAD(P) binding site [chemical binding]; other site 650150004626 active site 650150004627 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 650150004628 nudix motif; other site 650150004629 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 650150004630 mRNA/rRNA interface [nucleotide binding]; other site 650150004631 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 650150004632 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 650150004633 L7/L12 interface [polypeptide binding]; other site 650150004634 23S rRNA interface [nucleotide binding]; other site 650150004635 L25 interface [polypeptide binding]; other site 650150004636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150004637 Coenzyme A binding pocket [chemical binding]; other site 650150004638 transketolase; Reviewed; Region: PRK05899 650150004639 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 650150004640 TPP-binding site [chemical binding]; other site 650150004641 dimer interface [polypeptide binding]; other site 650150004642 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 650150004643 PYR/PP interface [polypeptide binding]; other site 650150004644 dimer interface [polypeptide binding]; other site 650150004645 TPP binding site [chemical binding]; other site 650150004646 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 650150004647 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 650150004648 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 650150004649 active site 650150004650 substrate binding site [chemical binding]; other site 650150004651 metal binding site [ion binding]; metal-binding site 650150004652 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 650150004653 dimerization domain swap beta strand [polypeptide binding]; other site 650150004654 regulatory protein interface [polypeptide binding]; other site 650150004655 active site 650150004656 regulatory phosphorylation site [posttranslational modification]; other site 650150004657 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 650150004658 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 650150004659 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 650150004660 protein binding site [polypeptide binding]; other site 650150004661 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: COG2248 650150004662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 650150004663 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150004664 G5 domain; Region: G5; pfam07501 650150004665 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004666 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 650150004667 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 650150004668 G5 domain; Region: G5; pfam07501 650150004669 Peptidase family M23; Region: Peptidase_M23; pfam01551 650150004670 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 650150004671 replicative DNA helicase; Region: DnaB; TIGR00665 650150004672 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 650150004673 Walker A motif; other site 650150004674 ATP binding site [chemical binding]; other site 650150004675 Walker B motif; other site 650150004676 DNA binding loops [nucleotide binding] 650150004677 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 650150004678 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 650150004679 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 650150004680 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 650150004681 DHH family; Region: DHH; pfam01368 650150004682 DHHA1 domain; Region: DHHA1; pfam02272 650150004683 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 650150004684 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 650150004685 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 650150004686 dimer interface [polypeptide binding]; other site 650150004687 ssDNA binding site [nucleotide binding]; other site 650150004688 tetramer (dimer of dimers) interface [polypeptide binding]; other site 650150004689 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 650150004690 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 650150004691 substrate binding site [chemical binding]; other site 650150004692 dimer interface [polypeptide binding]; other site 650150004693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 650150004694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004696 dimerization interface [polypeptide binding]; other site 650150004697 Chromate transporter; Region: Chromate_transp; pfam02417 650150004698 Chromate transporter; Region: Chromate_transp; pfam02417 650150004699 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 650150004700 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 650150004701 dimer interface [polypeptide binding]; other site 650150004702 putative anticodon binding site; other site 650150004703 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 650150004704 motif 1; other site 650150004705 active site 650150004706 motif 2; other site 650150004707 motif 3; other site 650150004708 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 650150004709 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 650150004710 dimerization interface [polypeptide binding]; other site 650150004711 domain crossover interface; other site 650150004712 redox-dependent activation switch; other site 650150004713 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 650150004714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150004715 Walker A motif; other site 650150004716 ATP binding site [chemical binding]; other site 650150004717 Walker B motif; other site 650150004718 arginine finger; other site 650150004719 Peptidase family M41; Region: Peptidase_M41; pfam01434 650150004720 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150004721 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 650150004722 Ligand Binding Site [chemical binding]; other site 650150004723 B3/4 domain; Region: B3_4; cl11458 650150004724 rod shape-determining protein Mbl; Provisional; Region: PRK13928 650150004725 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 650150004726 ATP binding site [chemical binding]; other site 650150004727 profilin binding site; other site 650150004728 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 650150004729 sodium/hydrogen exchanger, pseudogene, truncated by premature stop codon 650150004730 CutC family; Region: CutC; cl01218 650150004731 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150004732 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 650150004733 dimer interface [polypeptide binding]; other site 650150004734 glycine-pyridoxal phosphate binding site [chemical binding]; other site 650150004735 active site 650150004736 folate binding site [chemical binding]; other site 650150004737 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 650150004738 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 650150004739 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 650150004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150004741 S-adenosylmethionine binding site [chemical binding]; other site 650150004742 peptide chain release factor 1; Validated; Region: prfA; PRK00591 650150004743 RF-1 domain; Region: RF-1; cl02875 650150004744 RF-1 domain; Region: RF-1; cl02875 650150004745 Thymidine kinase; Region: TK; cl00631 650150004746 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 650150004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 650150004748 Coenzyme A binding pocket [chemical binding]; other site 650150004749 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 650150004750 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 650150004751 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 650150004752 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 650150004753 Uncharacterized conserved protein [Function unknown]; Region: COG2966 650150004754 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 650150004755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 650150004756 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 650150004757 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 650150004758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 650150004759 FeS/SAM binding site; other site 650150004760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 650150004761 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 650150004762 hinge; other site 650150004763 active site 650150004764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004765 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 650150004766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004767 dimer interface [polypeptide binding]; other site 650150004768 conserved gate region; other site 650150004769 ABC-ATPase subunit interface; other site 650150004770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004771 dimer interface [polypeptide binding]; other site 650150004772 conserved gate region; other site 650150004773 putative PBP binding loops; other site 650150004774 ABC-ATPase subunit interface; other site 650150004775 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 650150004776 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 650150004777 Walker A/P-loop; other site 650150004778 ATP binding site [chemical binding]; other site 650150004779 Q-loop/lid; other site 650150004780 ABC transporter signature motif; other site 650150004781 Walker B; other site 650150004782 D-loop; other site 650150004783 H-loop/switch region; other site 650150004784 FOG: CBS domain [General function prediction only]; Region: COG0517 650150004785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 650150004786 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 650150004787 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 650150004788 hypothetical protein; Provisional; Region: PRK08185 650150004789 intersubunit interface [polypeptide binding]; other site 650150004790 active site 650150004791 zinc binding site [ion binding]; other site 650150004792 Na+ binding site [ion binding]; other site 650150004793 CTP synthetase; Validated; Region: pyrG; PRK05380 650150004794 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 650150004795 Catalytic site [active] 650150004796 Active site [active] 650150004797 UTP binding site [chemical binding]; other site 650150004798 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 650150004799 active site 650150004800 putative oxyanion hole; other site 650150004801 catalytic triad [active] 650150004802 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 650150004803 proline aminopeptidase P II; Provisional; Region: PRK10879 650150004804 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 650150004805 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 650150004806 active site 650150004807 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 650150004808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 650150004809 Zn2+ binding site [ion binding]; other site 650150004810 Mg2+ binding site [ion binding]; other site 650150004811 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 650150004812 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 650150004813 active site 650150004814 HIGH motif; other site 650150004815 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 650150004816 active site 650150004817 KMSKS motif; other site 650150004818 putative acyltransferase; Provisional; Region: PRK05790 650150004819 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 650150004820 dimer interface [polypeptide binding]; other site 650150004821 active site 650150004822 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 650150004823 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 650150004824 dimer interface [polypeptide binding]; other site 650150004825 active site 650150004826 Protein of unknown function (DUF419); Region: DUF419; cl09948 650150004827 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 650150004828 active site 650150004829 metal binding site [ion binding]; metal-binding site 650150004830 Nitrogen regulatory protein P-II; Region: P-II; cl00412 650150004831 GTP-binding protein YchF; Reviewed; Region: PRK09601 650150004832 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 650150004833 G1 box; other site 650150004834 GTP/Mg2+ binding site [chemical binding]; other site 650150004835 Switch I region; other site 650150004836 G2 box; other site 650150004837 Switch II region; other site 650150004838 G3 box; other site 650150004839 G4 box; other site 650150004840 G5 box; other site 650150004841 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 650150004842 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 650150004843 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 650150004844 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 650150004845 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 650150004846 homodimer interface [polypeptide binding]; other site 650150004847 NADP binding site [chemical binding]; other site 650150004848 substrate binding site [chemical binding]; other site 650150004849 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 650150004850 putative active site [active] 650150004851 dimerization interface [polypeptide binding]; other site 650150004852 putative tRNAtyr binding site [nucleotide binding]; other site 650150004853 recombination factor protein RarA; Reviewed; Region: PRK13342 650150004854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 650150004855 Walker A motif; other site 650150004856 ATP binding site [chemical binding]; other site 650150004857 Walker B motif; other site 650150004858 arginine finger; other site 650150004859 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 650150004860 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 650150004861 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 650150004862 NADP binding site [chemical binding]; other site 650150004863 dimer interface [polypeptide binding]; other site 650150004864 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 650150004865 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 650150004866 ATP binding site [chemical binding]; other site 650150004867 Mg++ binding site [ion binding]; other site 650150004868 motif III; other site 650150004869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150004870 nucleotide binding region [chemical binding]; other site 650150004871 ATP-binding site [chemical binding]; other site 650150004872 DbpA RNA binding domain; Region: DbpA; pfam03880 650150004873 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 650150004874 active site 650150004875 DNA binding site [nucleotide binding] 650150004876 putative phosphate binding site [ion binding]; other site 650150004877 putative catalytic site [active] 650150004878 metal binding site A [ion binding]; metal-binding site 650150004879 AP binding site [nucleotide binding]; other site 650150004880 metal binding site B [ion binding]; metal-binding site 650150004881 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 650150004882 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 650150004883 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 650150004884 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150004885 UvrD/REP helicase; Region: UvrD-helicase; cl14126 650150004886 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 650150004887 nudix motif; other site 650150004888 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 650150004889 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 650150004890 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 650150004891 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 650150004892 Substrate binding site [chemical binding]; other site 650150004893 Mg++ binding site [ion binding]; other site 650150004894 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 650150004895 active site 650150004896 substrate binding site [chemical binding]; other site 650150004897 CoA binding site [chemical binding]; other site 650150004898 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 650150004899 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 650150004900 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 650150004901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150004902 S-adenosylmethionine binding site [chemical binding]; other site 650150004903 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 650150004904 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 650150004905 putative active site [active] 650150004906 putative metal binding site [ion binding]; other site 650150004907 3D domain; Region: 3D; cl01439 650150004908 QueT transporter; Region: QueT; cl01932 650150004909 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 650150004910 NAD(P) binding site [chemical binding]; other site 650150004911 catalytic residues [active] 650150004912 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 650150004913 amidohydrolase; Region: amidohydrolases; TIGR01891 650150004914 metal binding site [ion binding]; metal-binding site 650150004915 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 650150004916 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 650150004917 Walker A/P-loop; other site 650150004918 ATP binding site [chemical binding]; other site 650150004919 Q-loop/lid; other site 650150004920 ABC transporter signature motif; other site 650150004921 Walker B; other site 650150004922 D-loop; other site 650150004923 H-loop/switch region; other site 650150004924 NIL domain; Region: NIL; pfam09383 650150004925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 650150004926 dimer interface [polypeptide binding]; other site 650150004927 conserved gate region; other site 650150004928 ABC-ATPase subunit interface; other site 650150004929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 650150004930 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 650150004931 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 650150004932 active site 650150004933 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 650150004934 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 650150004935 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 650150004936 G1 box; other site 650150004937 GTP/Mg2+ binding site [chemical binding]; other site 650150004938 Switch I region; other site 650150004939 G2 box; other site 650150004940 Switch II region; other site 650150004941 G3 box; other site 650150004942 G4 box; other site 650150004943 G5 box; other site 650150004944 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 650150004945 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 650150004946 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650 650150004947 active site 650150004948 ParB-like nuclease domain; Region: ParBc; cl02129 650150004949 ParB-like partition proteins; Region: parB_part; TIGR00180 650150004950 KorB domain; Region: KorB; pfam08535 650150004951 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 650150004952 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 650150004953 P-loop; other site 650150004954 Magnesium ion binding site [ion binding]; other site 650150004955 ParB-like partition proteins; Region: parB_part; TIGR00180 650150004956 ParB-like nuclease domain; Region: ParBc; cl02129 650150004957 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 650150004958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 650150004959 S-adenosylmethionine binding site [chemical binding]; other site 650150004960 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 650150004961 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 650150004962 G1 box; other site 650150004963 putative GEF interaction site [polypeptide binding]; other site 650150004964 GTP/Mg2+ binding site [chemical binding]; other site 650150004965 Switch I region; other site 650150004966 G2 box; other site 650150004967 G3 box; other site 650150004968 Switch II region; other site 650150004969 G4 box; other site 650150004970 G5 box; other site 650150004971 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 650150004972 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to...; Region: Elongation_Factor_C; cl02785 650150004973 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 650150004974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 650150004975 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 650150004976 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 650150004977 Predicted transcriptional regulators [Transcription]; Region: COG1725 650150004978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 650150004979 DNA-binding site [nucleotide binding]; DNA binding site 650150004980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 650150004981 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 650150004982 Walker A/P-loop; other site 650150004983 ATP binding site [chemical binding]; other site 650150004984 Q-loop/lid; other site 650150004985 ABC transporter signature motif; other site 650150004986 Walker B; other site 650150004987 D-loop; other site 650150004988 H-loop/switch region; other site 650150004989 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 650150004990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 650150004991 catalytic core [active] 650150004992 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 650150004993 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 650150004994 active site 650150004995 HIGH motif; other site 650150004996 KMSKS motif; other site 650150004997 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 650150004998 tRNA binding surface [nucleotide binding]; other site 650150004999 anticodon binding site; other site 650150005000 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 650150005001 dimer interface [polypeptide binding]; other site 650150005002 putative tRNA-binding site [nucleotide binding]; other site 650150005003 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 650150005004 metal ion-dependent adhesion site (MIDAS); other site 650150005005 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150005006 domain interaction interfaces; other site 650150005007 putative ligand binding motif; other site 650150005008 putative Ca2+ binding sites [ion binding]; other site 650150005009 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150005010 putative Ca2+ binding sites [ion binding]; other site 650150005011 domain interaction interfaces; other site 650150005012 putative ligand binding motif; other site 650150005013 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150005014 putative Ca2+ binding sites [ion binding]; other site 650150005015 domain interaction interfaces; other site 650150005016 putative ligand binding motif; other site 650150005017 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 650150005018 putative Ca2+ binding sites [ion binding]; other site 650150005019 domain interaction interfaces; other site 650150005020 putative ligand binding motif; other site 650150005021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 650150005022 non-specific DNA binding site [nucleotide binding]; other site 650150005023 salt bridge; other site 650150005024 sequence-specific DNA binding site [nucleotide binding]; other site 650150005025 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 650150005026 metal binding site 2 [ion binding]; metal-binding site 650150005027 putative DNA binding helix; other site 650150005028 metal binding site 1 [ion binding]; metal-binding site 650150005029 dimer interface [polypeptide binding]; other site 650150005030 structural Zn2+ binding site [ion binding]; other site 650150005031 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 650150005032 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 650150005033 active site 650150005034 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 650150005035 Predicted methyltransferases [General function prediction only]; Region: COG0313 650150005036 DNA polymerase III subunit delta'; Validated; Region: PRK08058 650150005037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 650150005038 thymidylate kinase; Validated; Region: tmk; PRK00698 650150005039 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 650150005040 TMP-binding site; other site 650150005041 ATP-binding site [chemical binding]; other site 650150005042 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 650150005043 dimer interface [polypeptide binding]; other site 650150005044 ADP-ribose binding site [chemical binding]; other site 650150005045 active site 650150005046 nudix motif; other site 650150005047 metal binding site [ion binding]; metal-binding site 650150005048 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 650150005049 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 650150005050 active site 650150005051 Septum formation initiator; Region: DivIC; cl11433 650150005052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 650150005053 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 650150005054 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 650150005055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 650150005056 ATP binding site [chemical binding]; other site 650150005057 putative Mg++ binding site [ion binding]; other site 650150005058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 650150005059 nucleotide binding region [chemical binding]; other site 650150005060 ATP-binding site [chemical binding]; other site 650150005061 TRCF domain; Region: TRCF; pfam03461 650150005062 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 650150005063 putative active site [active] 650150005064 catalytic residue [active] 650150005065 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 650150005066 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 650150005067 G-X-X-G motif; other site 650150005068 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 650150005069 RxxxH motif; other site 650150005070 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 650150005071 Ribonuclease P; Region: Ribonuclease_P; cl00457 650150005072 Ribosomal protein L34; Region: Ribosomal_L34; cl00370