-- dump date 20140619_075729 -- class Genbank::CDS -- table cds_note -- id note YP_456890.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_456891.1 COG2831 Hemolysin activation/secretion protein YP_456892.1 COG2771 DNA-binding HTH domain-containing proteins YP_456893.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_456894.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_456895.1 COG0477 Permeases of the major facilitator superfamily YP_456896.1 COG1960 Acyl-CoA dehydrogenases YP_456898.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_456899.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_456900.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_456901.1 COG1960 Acyl-CoA dehydrogenases YP_456902.1 binds directly to 23S ribosomal RNA YP_456903.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_456905.1 COG0726 Predicted xylanase/chitin deacetylase YP_456906.1 COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA YP_456907.1 COG2072 Predicted flavoprotein involved in K+ transport YP_456908.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_456909.1 COG2124 Cytochrome P450 YP_456910.1 COG0582 Integrase YP_456912.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_456914.1 COG0001 Glutamate-1-semialdehyde aminotransferase YP_456915.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_456916.1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_456918.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_456919.1 COG0117 Pyrimidine deaminase YP_456921.1 COG1451 Predicted metal-dependent hydrolase YP_456922.1 COG2983 Uncharacterized conserved protein YP_456923.1 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems YP_456924.1 COG0666 FOG: Ankyrin repeat YP_456925.1 COG5590 Uncharacterized conserved protein YP_456926.1 COG1918 Fe2+ transport system protein A YP_456927.1 COG0370 Fe2+ transport system protein B YP_456928.1 COG0629 Single-stranded DNA-binding protein YP_456931.1 COG2913 Small protein A (tmRNA-binding) YP_456932.1 heat shock protein involved in degradation of misfolded proteins YP_456933.1 heat shock protein involved in degradation of misfolded proteins YP_456934.1 COG3602 Uncharacterized protein conserved in bacteria YP_456935.1 COG0659 Sulfate permease and related transporters (MFS superfamily) YP_456936.1 COG0612 Predicted Zn-dependent peptidases YP_456937.1 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase component YP_456939.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_456940.1 COG0136 Aspartate-semialdehyde dehydrogenase YP_456941.1 COG0076 Glutamate decarboxylase and related PLP-dependent proteins YP_456943.1 COG0457 FOG: TPR repeat YP_456944.1 COG3872 Predicted metal-dependent enzyme YP_456945.1 COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_456946.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_456947.1 COG2211 Na+/melibiose symporter and related transporters YP_456948.1 COG1960 Acyl-CoA dehydrogenases YP_456949.1 COG1960 Acyl-CoA dehydrogenases YP_456950.1 COG0477 Permeases of the major facilitator superfamily YP_456951.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_456952.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_456953.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_456954.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_456955.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_456956.1 COG0477 Permeases of the major facilitator superfamily YP_456957.1 COG0625 Glutathione S-transferase YP_456958.1 COG0535 Predicted Fe-S oxidoreductases YP_456959.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_456960.1 COG0500 SAM-dependent methyltransferases YP_456961.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_456962.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_456963.1 COG3222 Uncharacterized protein conserved in bacteria YP_456964.1 COG0534 Na+-driven multidrug efflux pump YP_456965.1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs YP_456966.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_456967.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_456968.1 COG0477 Permeases of the major facilitator superfamily YP_456969.1 COG3963 Phospholipid N-methyltransferase YP_456971.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_456973.1 COG2301 Citrate lyase beta subunit YP_456974.1 COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_456975.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_456976.1 COG4325 Predicted membrane protein YP_456977.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_456978.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_456980.1 COG0457 FOG: TPR repeat YP_456981.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_456982.1 COG1292 Choline-glycine betaine transporter YP_456983.1 COG4258 Predicted exporter YP_456984.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_456985.1 COG0554 Glycerol kinase YP_456988.1 COG2841 Uncharacterized protein conserved in bacteria YP_456989.1 COG3605 Signal transduction protein containing GAF and PtsI domains YP_456990.1 COG1426 Uncharacterized protein conserved in bacteria YP_456991.1 COG1729 Uncharacterized protein conserved in bacteria YP_456992.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_456993.1 COG1881 Phospholipid-binding protein YP_456994.1 COG2352 Phosphoenolpyruvate carboxylase YP_456995.1 COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase YP_456996.1 COG0837 Glucokinase YP_456997.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_456998.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_456999.1 COG1305 Transglutaminase-like enzymes, cysteine proteases YP_457000.1 COG5295 Autotransporter adhesin YP_457001.1 COG5343 Uncharacterized protein conserved in bacteria YP_457002.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_457003.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_457004.1 COG0531 Amino acid transporters YP_457008.1 COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_457009.1 COG0739 Membrane proteins related to metalloendopeptidases YP_457010.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_457011.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_457012.1 COG0457 FOG: TPR repeat YP_457013.1 COG0582 Integrase YP_457015.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_457017.1 COG0286 Type I restriction-modification system methyltransferase subunit YP_457018.1 COG1475 Predicted transcriptional regulators YP_457019.1 COG4227 Antirestriction protein YP_457024.1 COG3311 Predicted transcriptional regulator YP_457025.1 COG0775 Nucleoside phosphorylase YP_457026.1 COG0438 Glycosyltransferase YP_457028.1 COG0629 Single-stranded DNA-binding protein YP_457032.1 COG0582 Integrase YP_457033.1 COG0582 Integrase YP_457034.1 COG0456 acetyltransferases YP_457035.1 COG1002 Type II restriction enzyme, methylase subunits YP_457037.1 COG2801 Transposase and inactivated derivatives YP_457038.1 COG2801 Transposase and inactivated derivatives YP_457039.1 COG0587 DNA polymerase III, alpha subunit YP_457040.1 COG3593 Predicted ATP-dependent endonuclease of the OLD family YP_457041.1 COG2801 Transposase and inactivated derivatives YP_457042.1 COG2801 Transposase and inactivated derivatives YP_457044.1 COG3505 Type IV secretory pathway, VirD4 components YP_457045.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_457046.1 COG3236 Uncharacterized protein conserved in bacteria YP_457047.1 COG0524 Sugar kinases, ribokinase family YP_457048.1 COG0561 Predicted hydrolases of the HAD superfamily YP_457050.1 COG1219 ATP-dependent protease Clp, ATPase subunit YP_457052.1 COG2932 Predicted transcriptional regulator YP_457055.1 COG1525 Micrococcal nuclease (thermonuclease) homologs YP_457059.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_457060.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell YP_457064.1 COG0681 Signal peptidase I YP_457067.1 COG3451 Type IV secretory pathway, VirB4 components YP_457069.1 COG1651 Protein-disulfide isomerase YP_457076.1 COG3311 Predicted transcriptional regulator YP_457077.1 COG0583 Transcriptional regulator YP_457078.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457080.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457081.1 COG3540 Phosphodiesterase/alkaline phosphatase D YP_457082.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_457084.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_457085.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_457086.1 COG0183 Acetyl-CoA acetyltransferase YP_457087.1 COG1960 Acyl-CoA dehydrogenases YP_457088.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457089.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457090.1 COG0583 Transcriptional regulator YP_457091.1 COG2801 Transposase and inactivated derivatives YP_457092.2 COG2963 Transposase and inactivated derivatives YP_457093.1 COG3311 Predicted transcriptional regulator YP_457094.1 COG0616 Periplasmic serine proteases (ClpP class) YP_457095.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_457096.1 COG0044 Dihydroorotase and related cyclic amidohydrolases YP_457098.1 COG0457 FOG: TPR repeat YP_457100.1 COG1192 ATPases involved in chromosome partitioning YP_457101.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_457102.1 COG2311 Predicted membrane protein YP_457103.1 COG2906 Bacterioferritin-associated ferredoxin YP_457104.1 COG2193 Bacterioferritin (cytochrome b1) YP_457105.1 COG0477 Permeases of the major facilitator superfamily YP_457106.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_457107.1 COG3942 Surface antigen YP_457109.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_457111.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_457112.1 COG0025 NhaP-type Na+/H+ and K+/H+ antiporters YP_457113.1 COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_457114.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457116.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_457117.1 binds and unfolds substrates as part of the ClpXP protease YP_457119.1 COG2335 Secreted and surface protein containing fasciclin-like repeats YP_457120.1 COG5343 Uncharacterized protein conserved in bacteria YP_457121.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_457122.1 COG1230 Co/Zn/Cd efflux system component YP_457123.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein) YP_457124.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_457125.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_457126.1 COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily YP_457127.1 COG0642 Signal transduction histidine kinase YP_457128.1 COG3023 Negative regulator of beta-lactamase expression YP_457129.1 COG1357 Uncharacterized low-complexity proteins YP_457130.1 COG3591 V8-like Glu-specific endopeptidase YP_457132.1 COG1004 Predicted UDP-glucose 6-dehydrogenase YP_457133.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases YP_457135.1 COG2859 Uncharacterized protein conserved in bacteria YP_457136.1 COG0346 Lactoylglutathione lyase and related lyases YP_457137.1 COG3004 Na+/H+ antiporter YP_457138.1 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis YP_457141.1 COG2987 Urocanate hydratase YP_457142.1 COG0730 Predicted permeases YP_457144.1 COG0433 Predicted ATPase YP_457145.1 COG0602 Organic radical activating enzymes YP_457146.1 COG3228 Uncharacterized protein conserved in bacteria YP_457147.1 COG0525 Valyl-tRNA synthetase YP_457148.1 COG0525 Valyl-tRNA synthetase YP_457149.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component YP_457150.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component YP_457151.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_457152.1 COG3218 ABC-type uncharacterized transport system, auxiliary component YP_457153.1 COG1278 Cold shock proteins YP_457155.1 COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase YP_457157.1 COG0546 Predicted phosphatases YP_457158.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_457159.1 COG0239 Integral membrane protein possibly involved in chromosome condensation YP_457160.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_457161.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_457162.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_457164.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_457165.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_457166.1 COG0500 SAM-dependent methyltransferases YP_457167.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_457168.1 COG0219 Predicted rRNA methylase (SpoU class) YP_457173.1 COG0612 Predicted Zn-dependent peptidases YP_457174.1 COG2366 Protein related to penicillin acylase YP_457175.1 COG0433 Predicted ATPase YP_457176.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_457177.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457178.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_457180.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457181.1 COG0500 SAM-dependent methyltransferases YP_457182.1 COG0457 FOG: TPR repeat YP_457183.1 COG5040 14-3-3 family protein YP_457184.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_457185.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457186.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_457187.1 COG0005 Purine nucleoside phosphorylase YP_457188.1 COG1846 Transcriptional regulators YP_457189.1 COG2064 Flp pilus assembly protein TadC YP_457190.1 COG4965 Flp pilus assembly protein TadB YP_457191.1 COG0784 FOG: CheY-like receiver YP_457193.1 COG4964 Flp pilus assembly protein, secretin CpaC YP_457194.1 COG3745 Flp pilus assembly protein CpaB YP_457195.1 COG4960 Flp pilus assembly protein, protease CpaA YP_457196.1 COG2267 Lysophospholipase YP_457197.1 COG0665 Glycine/D-amino acid oxidases (deaminating) YP_457198.1 COG3422 Uncharacterized conserved protein YP_457199.1 COG0328 Ribonuclease HI YP_457200.1 COG2334 homoserine kinase type II (protein kinase fold) YP_457201.1 COG0761 Penicillin tolerance protein YP_457203.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_457205.1 COG1472 Beta-glucosidase-related glycosidases YP_457206.1 COG1354 Uncharacterized conserved protein YP_457207.1 COG1386 Predicted transcriptional regulator containing the HTH domain YP_457208.1 COG1826 Sec-independent protein secretion pathway components YP_457209.1 COG1826 Sec-independent protein secretion pathway components YP_457210.1 COG0805 Sec-independent protein secretion pathway component TatC YP_457213.1 COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold YP_457214.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_457215.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_457216.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_457217.1 COG0729 Outer membrane protein YP_457218.1 COG2911 Uncharacterized protein conserved in bacteria YP_457219.1 COG2335 Secreted and surface protein containing fasciclin-like repeats YP_457221.1 COG0174 Glutamine synthetase YP_457222.1 COG0347 Nitrogen regulatory protein PII YP_457223.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis YP_457225.1 COG0260 Leucyl aminopeptidase YP_457226.1 COG1257 Hydroxymethylglutaryl-CoA reductase YP_457227.1 COG0024 Methionine aminopeptidase YP_457228.1 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_457229.1 COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component YP_457230.1 COG2154 Pterin-4a-carbinolamine dehydratase YP_457231.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457232.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_457233.1 COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase YP_457234.1 COG0633 Ferredoxin YP_457235.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_457237.1 COG3225 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component YP_457239.1 COG2001 Uncharacterized protein conserved in bacteria YP_457240.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_457242.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_457243.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_457244.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase YP_457245.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_457246.1 COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase YP_457247.1 COG0772 Bacterial cell division membrane protein YP_457248.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_457249.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_457250.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_457251.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_457252.1 COG1589 Cell division septal protein YP_457253.1 COG0849 Actin-like ATPase involved in cell division YP_457254.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_457255.1 COG0457 FOG: TPR repeat YP_457256.1 COG5465 Uncharacterized conserved protein YP_457257.1 COG0345 Pyrroline-5-carboxylate reductase YP_457258.1 COG0670 Integral membrane protein, interacts with FtsH YP_457260.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_457261.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_457262.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_457263.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_457264.1 COG3749 Uncharacterized protein conserved in bacteria YP_457265.1 COG0155 Sulfite reductase, beta subunit (hemoprotein) YP_457267.1 COG0007 Uroporphyrinogen-III methylase YP_457268.1 COG3264 Small-conductance mechanosensitive channel YP_457269.1 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases YP_457270.1 COG2897 Rhodanese-related sulfurtransferase YP_457273.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_457274.1 COG0489 ATPases involved in chromosome partitioning YP_457275.1 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component YP_457276.1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase YP_457277.1 COG1695 Predicted transcriptional regulators YP_457278.1 COG0477 Permeases of the major facilitator superfamily YP_457279.1 COG0438 Glycosyltransferase YP_457280.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_457283.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_457284.1 COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis YP_457285.1 COG0656 Aldo/keto reductases, related to diketogulonate reductase YP_457286.1 COG4102 Uncharacterized protein conserved in bacteria YP_457287.1 COG5267 Uncharacterized protein conserved in bacteria YP_457288.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_457289.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_457290.1 COG3034 Uncharacterized protein conserved in bacteria YP_457292.1 COG1846 Transcriptional regulators YP_457293.1 COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) YP_457294.1 COG0019 Diaminopimelate decarboxylase YP_457296.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_457297.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_457298.1 COG0500 SAM-dependent methyltransferases YP_457299.1 COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D YP_457300.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_457301.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_457302.1 COG0223 Methionyl-tRNA formyltransferase YP_457304.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_457305.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_457306.1 COG1145 Ferredoxin YP_457307.1 COG1322 Uncharacterized protein conserved in bacteria YP_457309.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_457310.1 COG0566 rRNA methylases YP_457311.1 COG1925 Phosphotransferase system, HPr-related proteins YP_457312.1 COG2893 Phosphotransferase system, mannose/fructose-specific component IIA YP_457313.2 COG1660 Predicted P-loop-containing kinase YP_457314.1 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism YP_457315.1 COG0642 Signal transduction histidine kinase YP_457316.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_457317.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_457319.1 COG0642 Signal transduction histidine kinase YP_457320.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_457323.1 COG4805 Uncharacterized protein conserved in bacteria YP_457325.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_457326.1 COG2945 Predicted hydrolase of the alpha/beta superfamily YP_457327.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_457329.1 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_457330.1 COG0633 Ferredoxin YP_457331.1 COG2771 DNA-binding HTH domain-containing proteins YP_457332.1 COG1196 Chromosome segregation ATPases YP_457333.1 COG0693 intracellular protease/amidase YP_457336.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_457338.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase YP_457339.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_457340.1 COG3816 Uncharacterized protein conserved in bacteria YP_457341.1 COG3153 Predicted acetyltransferase YP_457342.1 COG2133 Glucose/sorbosone dehydrogenases YP_457343.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_457344.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457345.1 COG0583 Transcriptional regulator YP_457346.1 COG3004 Na+/H+ antiporter YP_457347.1 COG0530 Ca2+/Na+ antiporter YP_457348.1 COG0863 DNA modification methylase YP_457349.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_457350.1 COG0294 Dihydropteroate synthase and related enzymes YP_457351.1 COG3540 Phosphodiesterase/alkaline phosphatase D YP_457352.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457354.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_457356.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_457357.1 COG2335 Secreted and surface protein containing fasciclin-like repeats YP_457358.1 COG3288 NAD/NADP transhydrogenase alpha subunit YP_457359.1 COG1282 NAD/NADP transhydrogenase beta subunit YP_457363.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457364.1 COG1794 Aspartate racemase YP_457365.1 COG0232 dGTP triphosphohydrolase YP_457366.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_457367.1 COG0477 Permeases of the major facilitator superfamily YP_457368.1 COG5510 Predicted small secreted protein YP_457369.1 COG5510 Predicted small secreted protein YP_457370.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_457372.1 COG4962 Flp pilus assembly protein, ATPase CpaF YP_457374.1 COG1487 Predicted nucleic acid-binding protein, contains PIN domain YP_457375.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_457376.1 COG2199 FOG: GGDEF domain YP_457377.1 COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain YP_457378.1 COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component YP_457379.1 COG0612 Predicted Zn-dependent peptidases YP_457380.1 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_457381.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_457382.1 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism YP_457383.1 COG3024 Uncharacterized protein conserved in bacteria YP_457384.1 COG1530 Ribonucleases G and E YP_457385.1 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation YP_457386.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_457387.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457388.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457389.1 COG0244 Ribosomal protein L10 YP_457390.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_457391.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_457392.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_457393.1 COG2205 Osmosensitive K+ channel histidine kinase YP_457394.1 COG0534 Na+-driven multidrug efflux pump YP_457395.1 COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes YP_457396.1 COG3727 DNA G:T-mismatch repair endonuclease YP_457400.1 COG1946 Acyl-CoA thioesterase YP_457401.1 COG2850 Uncharacterized conserved protein YP_457403.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_457405.1 COG3239 Fatty acid desaturase YP_457406.1 COG0611 Thiamine monophosphate kinase YP_457407.1 COG0781 Transcription termination factor YP_457408.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_457409.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_457410.1 COG4427 Uncharacterized protein conserved in bacteria YP_457411.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457412.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_457413.1 COG1741 Pirin-related protein YP_457415.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_457416.1 COG0271 Stress-induced morphogen (activity unknown) YP_457417.1 COG2214 DnaJ-class molecular chaperone YP_457418.1 COG3865 Uncharacterized protein conserved in bacteria YP_457419.1 COG0625 Glutathione S-transferase YP_457420.1 COG3324 Predicted enzyme related to lactoylglutathione lyase YP_457421.1 COG5507 Uncharacterized conserved protein YP_457422.1 COG3662 Uncharacterized protein conserved in bacteria YP_457423.1 COG0714 MoxR-like ATPases YP_457424.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein) YP_457425.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457426.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457427.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_457429.1 COG0628 Predicted permease YP_457430.1 COG0681 Signal peptidase I YP_457431.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_457432.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_457433.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_457434.1 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 YP_457435.1 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 YP_457436.1 converts protoheme IX and farnesyl diphosphate to heme O YP_457438.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_457439.1 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 YP_457440.1 COG3346 Uncharacterized conserved protein YP_457441.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_457442.1 COG1092 Predicted SAM-dependent methyltransferases YP_457443.1 COG1539 Dihydroneopterin aldolase YP_457445.1 COG2896 Molybdenum cofactor biosynthesis enzyme YP_457446.1 COG1977 Molybdopterin converting factor, small subunit YP_457447.1 COG0314 Molybdopterin converting factor, large subunit YP_457449.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_457451.1 COG0261 Ribosomal protein L21 YP_457452.1 involved in the peptidyltransferase reaction during translation YP_457453.1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_457454.1 COG3687 Predicted metal-dependent hydrolase YP_457455.1 COG1309 Transcriptional regulator YP_457456.1 COG0354 Predicted aminomethyltransferase related to GcvT YP_457457.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_457458.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) YP_457459.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_457460.1 COG2962 Predicted permeases YP_457463.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_457464.1 COG0397 Uncharacterized conserved protein YP_457465.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457466.1 COG0438 Glycosyltransferase YP_457468.1 COG1520 FOG: WD40-like repeat YP_457469.1 COG2020 protein-S-isoprenylcysteine methyltransferase YP_457471.1 COG1359 Uncharacterized conserved protein YP_457472.1 COG3572 Gamma-glutamylcysteine synthetase YP_457473.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_457474.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_457475.1 COG1199 Rad3-related DNA helicases YP_457476.1 COG2062 Phosphohistidine phosphatase SixA YP_457479.1 COG0789 Predicted transcriptional regulators YP_457480.1 COG0346 Lactoylglutathione lyase and related lyases YP_457481.1 COG0477 Permeases of the major facilitator superfamily YP_457482.1 COG0730 Predicted permeases YP_457484.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_457485.1 COG2202 FOG: PAS/PAC domain YP_457490.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 YP_457492.1 COG0513 Superfamily II DNA and RNA helicases YP_457495.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_457496.1 COG2199 FOG: GGDEF domain YP_457498.1 COG2234 Predicted aminopeptidases YP_457500.1 COG5662 Predicted transmembrane transcriptional regulator (anti-sigma factor) YP_457501.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_457502.1 COG1404 Subtilisin-like serine proteases YP_457505.1 COG0642 Signal transduction histidine kinase YP_457506.1 COG1522 Transcriptional regulators YP_457507.1 COG1288 Predicted membrane protein YP_457509.1 COG0439 Biotin carboxylase YP_457510.1 COG0511 Biotin carboxyl carrier protein YP_457511.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_457513.1 COG2030 Acyl dehydratase YP_457516.1 COG2827 Predicted endonuclease containing a URI domain YP_457517.1 COG2301 Citrate lyase beta subunit YP_457518.1 COG0366 Glycosidases YP_457519.1 COG0477 Permeases of the major facilitator superfamily YP_457520.1 COG1609 Transcriptional regulators YP_457521.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457523.1 COG0366 Glycosidases YP_457524.1 COG0366 Glycosidases YP_457526.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_457527.1 COG1609 Transcriptional regulators YP_457528.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457531.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_457532.1 COG3838 Type IV secretory pathway, VirB2 components (pilins) YP_457533.1 COG3702 Type IV secretory pathway, VirB3 components YP_457534.1 COG3451 Type IV secretory pathway, VirB4 components YP_457535.1 COG3704 Type IV secretory pathway, VirB6 components YP_457536.1 COG3504 Type IV secretory pathway, VirB9 components YP_457537.1 COG2948 Type IV secretory pathway, VirB10 components YP_457538.1 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_457539.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_457540.1 COG0248 Exopolyphosphatase YP_457541.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457542.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457543.1 COG1738 Uncharacterized conserved protein YP_457544.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_457545.1 COG0278 glutaredoxin-related protein YP_457546.1 COG0271 Stress-induced morphogen (activity unknown) YP_457547.1 COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 YP_457548.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_457549.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_457551.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_457552.1 COG0824 Predicted thioesterase YP_457553.1 COG3239 Fatty acid desaturase YP_457554.1 COG1230 Co/Zn/Cd efflux system component YP_457555.1 COG0401 Uncharacterized homolog of Blt101 YP_457556.1 COG2832 Uncharacterized protein conserved in bacteria YP_457557.1 COG2166 SufE protein probably involved in Fe-S center assembly YP_457559.1 COG0212 5-formyltetrahydrofolate cyclo-ligase YP_457563.1 COG0576 Molecular chaperone GrpE (heat shock protein) YP_457564.1 COG1196 Chromosome segregation ATPases YP_457566.1 COG1983 stress-responsive transcriptional regulator YP_457568.1 COG1196 Chromosome segregation ATPases YP_457570.1 COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain YP_457571.1 COG2337 Growth inhibitor YP_457573.1 COG2135 Uncharacterized conserved protein YP_457574.1 COG0779 Uncharacterized protein conserved in bacteria YP_457575.1 COG2262 GTPases YP_457576.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_457577.1 COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination YP_457578.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_457580.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457581.1 COG3797 Uncharacterized protein conserved in bacteria YP_457582.1 COG0858 Ribosome-binding factor A YP_457583.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_457584.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457585.1 COG2353 Uncharacterized conserved protein YP_457586.1 COG2978 p-aminobenzoyl-glutamate transporter YP_457587.1 COG1435 Thymidine kinase YP_457588.1 COG1994 Zn-dependent proteases YP_457589.1 COG0153 Galactokinase YP_457590.1 COG1085 Galactose-1-phosphate uridylyltransferase YP_457591.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_457592.1 COG3345 Alpha-galactosidase YP_457593.1 COG4146 Predicted symporter YP_457594.1 COG0130 Pseudouridine synthase YP_457595.1 COG0184 Ribosomal protein S15P/S13E YP_457596.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_457597.1 COG0421 Spermidine synthase YP_457598.1 COG3137 salt-induced outer membrane protein YP_457599.1 COG3812 Uncharacterized protein conserved in bacteria YP_457601.1 COG0842 ABC-type multidrug transport system, permease component YP_457602.1 COG3785 Uncharacterized conserved protein YP_457603.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_457604.1 COG3011 Uncharacterized protein conserved in bacteria YP_457605.1 COG4146 Predicted symporter YP_457607.1 COG1862 Preprotein translocase subunit YajC YP_457608.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_457609.1 COG0341 Preprotein translocase subunit SecF YP_457610.1 COG0438 Glycosyltransferase YP_457611.1 COG1396 Predicted transcriptional regulators YP_457613.1 COG1573 Uracil-DNA glycosylase YP_457614.1 COG0488 ATPase component of ABC transporters with duplicated ATPase domains YP_457615.1 COG1228 Imidazolonepropionase and related amidohydrolases YP_457616.1 COG2968 Uncharacterized conserved protein YP_457617.1 COG3212 Predicted membrane protein YP_457618.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_457619.1 COG0642 Signal transduction histidine kinase YP_457621.1 catalyzes the interconversion of chorismate to prephenate YP_457622.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_457623.1 COG1643 HrpA-like helicases YP_457624.1 COG0151 Phosphoribosylamine-glycine ligase YP_457625.2 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_457626.1 COG0718 Uncharacterized protein conserved in bacteria YP_457627.1 COG0466 ATP-dependent Lon protease, bacterial type YP_457628.1 COG0776 Bacterial nucleoid DNA-binding protein YP_457630.1 COG0566 rRNA methylases YP_457631.1 COG1874 Beta-galactosidase YP_457632.1 COG0673 Predicted dehydrogenases and related proteins YP_457633.1 COG0656 Aldo/keto reductases, related to diketogulonate reductase YP_457635.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_457636.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457637.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457638.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_457639.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_457640.1 COG1183 Phosphatidylserine synthase YP_457641.1 COG0477 Permeases of the major facilitator superfamily YP_457642.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_457643.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_457645.1 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III YP_457646.1 Catalyzes the phosphorylation of UMP to UDP YP_457647.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_457648.1 COG0020 Undecaprenyl pyrophosphate synthase YP_457649.1 COG0575 CDP-diglyceride synthetase YP_457650.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_457651.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1 YP_457652.1 COG4775 Outer membrane protein/protective antigen OMA87 YP_457653.1 COG0845 Membrane-fusion protein YP_457654.1 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-ACP dehydratases YP_457655.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_457657.1 COG1734 DnaK suppressor protein YP_457659.1 COG0334 Glutamate dehydrogenase/leucine dehydrogenase YP_457660.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_457662.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_457663.1 COG1138 Cytochrome c biogenesis factor YP_457664.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_457665.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes YP_457666.1 COG0457 FOG: TPR repeat YP_457667.1 COG3158 K+ transporter YP_457668.1 COG2827 Predicted endonuclease containing a URI domain YP_457669.1 COG2917 Intracellular septation protein A YP_457670.1 COG0552 Signal recognition particle GTPase YP_457671.1 COG0621 2-methylthioadenine synthetase YP_457672.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_457673.1 COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain YP_457674.1 COG2947 Uncharacterized conserved protein YP_457675.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_457677.1 COG0477 Permeases of the major facilitator superfamily YP_457678.1 COG0558 Phosphatidylglycerophosphate synthase YP_457680.1 COG0583 Transcriptional regulator YP_457681.1 COG0349 Ribonuclease D YP_457682.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_457686.1 carries the fatty acid chain in fatty acid biosynthesis YP_457687.1 COG0304 3-oxoacyl-ACP synthase YP_457688.1 COG1559 Predicted periplasmic solute-binding protein YP_457690.1 COG0582 Integrase YP_457691.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_457692.1 COG0358 DNA primase (bacterial type) YP_457695.1 COG1475 Predicted transcriptional regulators YP_457697.1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 YP_457700.1 COG4227 Antirestriction protein YP_457704.1 COG0629 Single-stranded DNA-binding protein YP_457707.1 COG0582 Integrase YP_457708.1 COG0582 Integrase YP_457709.1 COG2801 Transposase and inactivated derivatives YP_457710.1 COG2801 Transposase and inactivated derivatives YP_457712.1 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_457713.1 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_457714.1 COG1793 ATP-dependent DNA ligase YP_457715.1 COG1273 Uncharacterized conserved protein YP_457716.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_457717.1 COG0071 Molecular chaperone (small heat shock protein) YP_457718.1 COG0071 Molecular chaperone (small heat shock protein) YP_457720.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_457721.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_457724.1 COG2202 FOG: PAS/PAC domain YP_457725.1 COG2203 FOG: GAF domain YP_457726.1 COG0582 Integrase YP_457728.1 COG0629 Single-stranded DNA-binding protein YP_457731.1 COG3505 Type IV secretory pathway, VirD4 components YP_457732.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_457733.1 COG3550 Uncharacterized protein related to capsule biosynthesis enzymes YP_457734.1 COG3620 Predicted transcriptional regulator with C-terminal CBS domains YP_457735.1 COG1940 Transcriptional regulator/sugar kinase YP_457737.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457738.1 COG0477 Permeases of the major facilitator superfamily YP_457739.1 COG1609 Transcriptional regulators YP_457740.1 COG1715 Restriction endonuclease YP_457741.1 COG2932 Predicted transcriptional regulator YP_457744.1 COG1525 Micrococcal nuclease (thermonuclease) homologs YP_457746.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_457748.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_457749.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell YP_457753.1 COG0681 Signal peptidase I YP_457756.1 COG3451 Type IV secretory pathway, VirB4 components YP_457758.1 COG1651 Protein-disulfide isomerase YP_457765.1 COG3311 Predicted transcriptional regulator YP_457766.1 COG0789 Predicted transcriptional regulators YP_457768.1 COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis YP_457769.1 COG0450 Peroxiredoxin YP_457770.1 COG4772 Outer membrane receptor for Fe3+-dicitrate YP_457771.1 COG1230 Co/Zn/Cd efflux system component YP_457773.1 COG1230 Co/Zn/Cd efflux system component YP_457774.1 COG2217 Cation transport ATPase YP_457776.1 COG3696 silver efflux pump YP_457777.1 COG0845 Membrane-fusion protein YP_457778.1 COG1538 Outer membrane protein YP_457780.1 COG2010 Cytochrome c, mono- and diheme variants YP_457781.1 COG1230 Co/Zn/Cd efflux system component YP_457782.1 COG0789 Predicted transcriptional regulators YP_457783.1 COG0597 Lipoprotein signal peptidase YP_457784.1 catalyzes the condensation of two pyruvates to form acetolactate, implicated in pH homeostasis via the acetoin-2,3-butanediol pathway or in valine biosynthesis YP_457785.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_457786.1 COG0517 FOG: CBS domain YP_457789.1 COG0845 Membrane-fusion protein YP_457790.1 COG3696 silver efflux pump YP_457791.1 COG5569 Uncharacterized conserved protein YP_457792.1 COG2132 multicopper oxidases YP_457793.1 COG2217 Cation transport ATPase YP_457794.1 COG0730 Predicted permeases YP_457795.1 COG0640 Predicted transcriptional regulators YP_457796.1 COG3453 Uncharacterized protein conserved in bacteria YP_457797.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_457798.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_457799.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_457801.1 COG3544 Uncharacterized protein conserved in bacteria YP_457802.1 COG1226 Kef-type K+ transport systems, predicted NAD-binding component YP_457803.1 COG0695 glutaredoxin and related proteins YP_457804.1 COG0531 Amino acid transporters YP_457805.1 COG0477 Permeases of the major facilitator superfamily YP_457806.1 COG3019 Predicted metal-binding protein YP_457807.1 COG0500 SAM-dependent methyltransferases YP_457810.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_457811.1 COG2132 multicopper oxidases YP_457812.1 COG3667 Uncharacterized protein involved in copper resistance YP_457815.1 COG1285 Uncharacterized membrane protein YP_457819.1 COG4327 Predicted membrane protein YP_457820.1 COG4147 Predicted symporter YP_457821.1 COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases YP_457822.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_457823.1 COG1960 Acyl-CoA dehydrogenases YP_457824.1 COG1960 Acyl-CoA dehydrogenases YP_457825.1 COG1877 Trehalose-6-phosphatase YP_457826.1 COG3387 Glucoamylase and related glycosyl hydrolases YP_457827.1 COG0380 Trehalose-6-phosphate synthase YP_457828.1 COG2365 Protein tyrosine/serine phosphatase YP_457829.1 COG0492 Thioredoxin reductase YP_457830.1 COG5331 Uncharacterized protein conserved in bacteria YP_457832.1 COG1171 Threonine dehydratase YP_457833.1 COG1748 Saccharopine dehydrogenase and related proteins YP_457835.1 COG0019 Diaminopimelate decarboxylase YP_457836.1 COG0086 DNA-directed RNA polymerase, beta' subunit/160 kDa subunit YP_457837.1 COG1704 Uncharacterized conserved protein YP_457838.1 COG0019 Diaminopimelate decarboxylase YP_457839.1 COG1073 Hydrolases of the alpha/beta superfamily YP_457840.1 COG2202 FOG: PAS/PAC domain YP_457841.1 COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain YP_457842.1 COG2175 Probable taurine catabolism dioxygenase YP_457844.1 COG0778 Nitroreductase YP_457845.1 COG4430 Uncharacterized protein conserved in bacteria YP_457846.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_457847.1 COG0796 Glutamate racemase YP_457848.1 COG0344 Predicted membrane protein YP_457849.1 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_457851.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_457854.1 COG0784 FOG: CheY-like receiver YP_457856.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_457857.1 COG0571 dsRNA-specific ribonuclease YP_457858.1 COG0681 Signal peptidase I YP_457859.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_457861.1 COG2202 FOG: PAS/PAC domain YP_457864.1 COG0513 Superfamily II DNA and RNA helicases YP_457865.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_457866.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_457867.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_457868.1 COG0346 Lactoylglutathione lyase and related lyases YP_457869.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_457870.1 COG0625 Glutathione S-transferase YP_457871.1 MDM; functions in conversion of succinate to propionate YP_457873.1 COG0502 Biotin synthase and related enzymes YP_457876.1 COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit YP_457877.1 COG4122 Predicted O-methyltransferase YP_457878.1 COG0073 EMAP domain YP_457880.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_457881.1 COG1878 Predicted metal-dependent hydrolase YP_457882.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_457883.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_457886.1 COG4974 Site-specific recombinase XerD YP_457887.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_457888.1 COG4784 Zn-dependent protease YP_457889.1 COG3847 Flp pilus assembly protein, pilin Flp YP_457891.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_457893.1 COG0302 GTP cyclohydrolase I YP_457894.1 COG1309 Transcriptional regulator YP_457895.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_457896.1 COG0678 Peroxiredoxin YP_457897.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_457898.1 COG0642 Signal transduction histidine kinase YP_457899.1 COG0802 Predicted ATPase or kinase YP_457900.1 COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases YP_457901.1 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) YP_457902.1 COG3893 Inactivated superfamily I helicase YP_457903.1 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_457904.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_457905.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_457906.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_457908.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_457909.1 COG1280 threonine efflux protein YP_457910.1 catalyzes the phosphorylation of NAD to NADP YP_457911.1 COG2200 FOG: EAL domain YP_457912.1 COG1197 Transcription-repair coupling factor (superfamily II helicase) YP_457913.1 COG2938 Uncharacterized conserved protein YP_457914.1 COG1200 RecG-like helicase YP_457915.1 COG0394 Protein-tyrosine-phosphatase YP_457916.1 COG4805 Uncharacterized protein conserved in bacteria YP_457917.1 COG0661 Predicted unusual protein kinase YP_457918.1 COG0477 Permeases of the major facilitator superfamily YP_457919.1 COG0207 Thymidylate synthase YP_457920.1 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_457921.1 COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit YP_457922.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_457924.1 COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_457925.1 COG2211 Na+/melibiose symporter and related transporters YP_457927.1 COG0212 5-formyltetrahydrofolate cyclo-ligase YP_457928.1 COG3027 Uncharacterized protein conserved in bacteria YP_457929.1 COG0419 ATPase involved in DNA repair YP_457930.1 COG0021 Transketolase YP_457931.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_457932.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_457933.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457935.1 COG0655 Multimeric flavodoxin WrbA YP_457936.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis YP_457938.1 COG0352 Thiamine monophosphate synthase YP_457939.1 COG3409 peptidoglycan-binding domain-containing protein YP_457940.1 COG0739 Membrane proteins related to metalloendopeptidases YP_457942.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_457943.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_457944.1 COG0477 Permeases of the major facilitator superfamily YP_457945.1 COG0471 Di- and tricarboxylate transporters YP_457946.1 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_457949.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_457950.1 COG1396 Predicted transcriptional regulators YP_457952.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis YP_457953.1 COG2205 Osmosensitive K+ channel histidine kinase YP_457954.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_457955.1 COG0457 FOG: TPR repeat YP_457956.1 COG0385 Predicted Na+-dependent transporter YP_457957.1 COG2899 Uncharacterized protein conserved in bacteria YP_457958.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_457959.1 COG0733 Na+-dependent transporters of the SNF family YP_457960.1 COG0531 Amino acid transporters YP_457961.1 COG3871 Uncharacterized stress protein (general stress protein 26) YP_457963.1 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair YP_457964.1 COG4337 Uncharacterized protein conserved in bacteria YP_457965.1 COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif YP_457966.1 COG1573 Uracil-DNA glycosylase YP_457967.1 COG0587 DNA polymerase III, alpha subunit YP_457968.1 COG3921 Uncharacterized protein conserved in bacteria YP_457969.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_457970.1 COG0704 Phosphate uptake regulator YP_457971.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_457972.1 COG0581 ABC-type phosphate transport system, permease component YP_457973.1 COG0573 ABC-type phosphate transport system, permease component YP_457974.1 COG0642 Signal transduction histidine kinase YP_457975.1 COG0608 Single-stranded DNA-specific exonuclease YP_457976.1 COG0655 Multimeric flavodoxin WrbA YP_457978.1 COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_457979.1 COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold YP_457980.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_457981.1 COG0006 Xaa-Pro aminopeptidase YP_457982.1 COG0119 Isopropylmalate/homocitrate/citramalate synthases YP_457984.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_457985.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_457987.1 COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases YP_457989.1 COG2353 Uncharacterized conserved protein YP_457990.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_457991.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_457992.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_457993.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_457994.1 COG0560 Phosphoserine phosphatase YP_457996.1 COG0778 Nitroreductase YP_457997.1 COG4804 Uncharacterized conserved protein YP_458000.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_458002.1 COG4852 Predicted membrane protein YP_458003.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_458004.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_458005.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_458006.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_458007.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_458008.1 COG1131 ABC-type multidrug transport system, ATPase component YP_458009.1 COG0842 ABC-type multidrug transport system, permease component YP_458010.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_458011.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_458012.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_458014.1 COG1605 Chorismate mutase YP_458016.1 COG2827 Predicted endonuclease containing a URI domain YP_458017.1 COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_458019.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_458020.1 COG0698 Ribose 5-phosphate isomerase RpiB YP_458021.1 COG3000 Sterol desaturase YP_458022.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_458023.1 COG0358 DNA primase (bacterial type) YP_458025.1 COG1610 Uncharacterized conserved protein YP_458026.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_458028.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_458029.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_458030.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458037.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_458038.1 COG1846 Transcriptional regulators YP_458039.1 COG3173 Predicted aminoglycoside phosphotransferase YP_458041.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_458042.1 COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_458043.1 COG0772 Bacterial cell division membrane protein YP_458044.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_458046.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_458047.1 functions in MreBCD complex in some organisms YP_458048.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_458050.1 COG0695 glutaredoxin and related proteins YP_458052.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_458053.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458054.1 COG0563 Adenylate kinase and related kinases YP_458056.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_458057.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_458058.1 COG3735 Uncharacterized protein conserved in bacteria YP_458059.1 COG3735 Uncharacterized protein conserved in bacteria YP_458060.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_458061.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_458062.1 COG0751 Glycyl-tRNA synthetase, beta subunit YP_458063.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_458064.1 COG0500 SAM-dependent methyltransferases YP_458065.1 COG1040 Predicted amidophosphoribosyltransferases YP_458066.1 COG0139 Phosphoribosyl-AMP cyclohydrolase YP_458067.1 COG0789 Predicted transcriptional regulators YP_458068.1 COG1960 Acyl-CoA dehydrogenases YP_458069.1 COG0031 Cysteine synthase YP_458070.1 COG0477 Permeases of the major facilitator superfamily YP_458072.1 COG0162 Tyrosyl-tRNA synthetase YP_458074.1 COG3876 Uncharacterized protein conserved in bacteria YP_458075.1 COG3739 Uncharacterized integral membrane protein YP_458076.1 COG3825 Uncharacterized protein conserved in bacteria YP_458077.1 COG0840 Methyl-accepting chemotaxis protein YP_458078.1 COG1376 Uncharacterized protein conserved in bacteria YP_458079.1 COG0714 MoxR-like ATPases YP_458080.1 COG2367 Beta-lactamase class A YP_458081.1 COG1073 Hydrolases of the alpha/beta superfamily YP_458082.1 COG1359 Uncharacterized conserved protein YP_458083.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_458084.1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component YP_458085.1 COG0313 Predicted methyltransferases YP_458086.1 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_458087.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_458088.1 COG0582 Integrase YP_458089.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_458090.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_458091.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_458092.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_458093.1 COG0576 Molecular chaperone GrpE (heat shock protein) YP_458094.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_458095.1 COG4805 Uncharacterized protein conserved in bacteria YP_458099.1 COG2847 Uncharacterized protein conserved in bacteria YP_458100.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_458101.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_458102.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_458104.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_458105.1 COG1286 Uncharacterized membrane protein, required for colicin V production YP_458106.1 COG0822 NifU homolog involved in Fe-S cluster formation YP_458107.1 COG0477 Permeases of the major facilitator superfamily YP_458108.1 COG0787 Alanine racemase YP_458109.1 COG5394 Uncharacterized protein conserved in bacteria YP_458110.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_458111.1 COG2234 Predicted aminopeptidases YP_458112.1 COG0557 Exoribonuclease R YP_458113.1 COG0450 Peroxiredoxin YP_458114.1 COG0468 RecA/RadA recombinase YP_458115.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_458116.1 COG1607 Acyl-CoA hydrolase YP_458118.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_458119.1 COG1228 Imidazolonepropionase and related amidohydrolases YP_458121.1 COG0475 Kef-type K+ transport systems, membrane components YP_458125.1 COG4719 Uncharacterized protein conserved in bacteria YP_458127.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_458129.1 COG2951 Membrane-bound lytic murein transglycosylase B YP_458130.1 COG0797 Lipoproteins YP_458131.1 COG1686 D-alanyl-D-alanine carboxypeptidase YP_458132.1 COG0125 Thymidylate kinase YP_458133.1 COG0470 ATPase involved in DNA replication YP_458134.1 COG0143 Methionyl-tRNA synthetase YP_458135.1 COG0084 Mg-dependent DNase YP_458136.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I YP_458138.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_458139.1 COG1694 Predicted pyrophosphatase YP_458140.1 COG2262 GTPases YP_458141.1 stimulates the elongation of poly(A) tails YP_458142.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_458143.1 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation YP_458144.1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains YP_458145.1 COG3852 Signal transduction histidine kinase, nitrogen specific YP_458146.1 COG0042 tRNA-dihydrouridine synthase YP_458147.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations YP_458148.1 COG0470 ATPase involved in DNA replication YP_458149.1 COG1546 Uncharacterized protein (competence- and mitomycin-induced) YP_458150.1 COG2867 Oligoketide cyclase/lipid transport protein YP_458151.1 catalyzes the radical-mediated insertion of two sulfur atoms into an ACP (ACP) bound to an octanoyl group to produce a lipoyl group YP_458152.1 COG3329 Predicted permease YP_458153.1 COG0347 Nitrogen regulatory protein PII YP_458154.1 COG0288 Carbonic anhydrase YP_458155.1 COG1432 Uncharacterized conserved protein YP_458156.1 COG0457 FOG: TPR repeat YP_458157.1 negatively supercoils closed circular double-stranded DNA YP_458158.1 COG2175 Probable taurine catabolism dioxygenase YP_458159.1 COG3714 Predicted membrane protein YP_458160.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_458162.1 COG1562 Phytoene/squalene synthetase YP_458164.1 COG4961 Flp pilus assembly protein TadG YP_458165.1 COG4961 Flp pilus assembly protein TadG YP_458167.1 COG4961 Flp pilus assembly protein TadG YP_458169.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase YP_458170.1 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_458171.1 COG2919 Septum formation initiator YP_458172.1 COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins YP_458173.1 COG0346 Lactoylglutathione lyase and related lyases YP_458174.1 COG0668 Small-conductance mechanosensitive channel YP_458175.1 COG0477 Permeases of the major facilitator superfamily YP_458177.1 COG5319 Uncharacterized protein conserved in bacteria YP_458178.1 COG0388 Predicted amidohydrolase YP_458179.1 COG0695 glutaredoxin and related proteins YP_458180.1 COG0071 Molecular chaperone (small heat shock protein) YP_458181.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_458182.1 COG1314 Preprotein translocase subunit SecG YP_458183.1 COG0149 Triosephosphate isomerase YP_458185.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_458186.1 COG0147 Anthranilate/para-aminobenzoate synthases component I YP_458187.1 COG3698 Predicted periplasmic protein YP_458188.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458190.1 COG0512 Anthranilate/para-aminobenzoate synthases component II YP_458191.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_458192.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_458193.1 COG0315 Molybdenum cofactor biosynthesis enzyme YP_458194.1 COG0303 Molybdopterin biosynthesis enzyme YP_458195.1 Represses a number of genes involved in the response to DNA damage YP_458196.1 COG0658 Predicted membrane metal-binding protein YP_458197.1 COG0008 Glutamyl- and glutaminyl-tRNA synthetases YP_458198.1 COG0372 Citrate synthase YP_458200.1 COG0642 Signal transduction histidine kinase YP_458204.1 COG1196 Chromosome segregation ATPases YP_458206.1 COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily YP_458207.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_458208.1 COG0340 Biotin-(acetyl-CoA carboxylase) ligase YP_458209.1 Catalyzes the transfer of electrons from NADH to quinone YP_458210.1 COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) YP_458211.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_458212.1 COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) YP_458213.1 COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) YP_458214.1 Catalyzes the transfer of electrons from NADH to quinone YP_458215.1 COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) YP_458217.1 Catalyzes the transfer of electrons from NADH to quinone YP_458219.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_458222.1 COG1905 NADH:ubiquinone oxidoreductase 24 kDa subunit YP_458224.1 Catalyzes the transfer of electrons from NADH to quinone YP_458225.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_458226.1 COG0852 NADH:ubiquinone oxidoreductase 27 kDa subunit YP_458227.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_458228.1 COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) YP_458229.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_458230.1 COG0183 Acetyl-CoA acetyltransferase YP_458232.1 COG3807 Uncharacterized protein conserved in bacteria YP_458233.1 COG1052 Lactate dehydrogenase and related dehydrogenases YP_458234.1 COG0004 Ammonia permease YP_458235.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458236.1 COG0623 Enoyl-ACP reductase (NADH) YP_458237.1 COG0304 3-oxoacyl-ACP synthase YP_458238.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_458239.1 COG0500 SAM-dependent methyltransferases YP_458240.1 COG1186 Protein chain release factor B YP_458241.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein YP_458242.1 COG0860 N-acetylmuramoyl-L-alanine amidase YP_458244.1 COG1530 Ribonucleases G and E YP_458245.1 COG0500 SAM-dependent methyltransferases YP_458246.1 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes YP_458247.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458248.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_458249.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_458250.1 COG1485 Predicted ATPase YP_458251.1 regulator of pathogenicity factor RpfF; involved in synthesis of a diffusible signal factor involved in the regulation of extracellular enzymes YP_458252.1 COG0367 Asparagine synthase (glutamine-hydrolyzing) YP_458254.1 COG0438 Glycosyltransferase YP_458255.1 COG2348 Uncharacterized protein involved in methicillin resistance YP_458256.1 COG0726 Predicted xylanase/chitin deacetylase YP_458257.1 COG3267 Type II secretory pathway, component ExeA (predicted ATPase) YP_458258.1 COG0547 Anthranilate phosphoribosyltransferase YP_458259.1 COG0489 ATPases involved in chromosome partitioning YP_458261.1 COG1596 Periplasmic protein involved in polysaccharide export YP_458262.1 COG0019 Diaminopimelate decarboxylase YP_458263.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_458267.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458268.1 COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_458269.1 COG0062 Uncharacterized conserved protein YP_458271.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_458272.1 COG3931 Predicted N-formylglutamate amidohydrolase YP_458273.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_458274.1 COG2852 Uncharacterized protein conserved in bacteria YP_458275.1 COG0644 Dehydrogenases (flavoproteins) YP_458276.1 COG1573 Uracil-DNA glycosylase YP_458277.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_458278.1 COG0521 Molybdopterin biosynthesis enzymes YP_458279.1 COG0530 Ca2+/Na+ antiporter YP_458280.1 COG1533 DNA repair photolyase YP_458284.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_458285.1 COG0587 DNA polymerase III, alpha subunit YP_458287.1 COG0386 Glutathione peroxidase YP_458290.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_458291.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_458292.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_458293.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458295.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_458296.1 COG2230 Cyclopropane fatty acid synthase and related methyltransferases YP_458297.1 COG1757 Na+/H+ antiporter YP_458298.1 COG0415 Deoxyribodipyrimidine photolyase YP_458299.1 COG1988 Predicted membrane-bound metal-dependent hydrolases YP_458302.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_458303.1 COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit YP_458304.1 COG0657 Esterase/lipase YP_458305.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_458306.1 COG0457 FOG: TPR repeat YP_458307.1 COG0144 tRNA and rRNA cytosine-C5-methylases YP_458308.1 COG0516 IMP dehydrogenase/GMP reductase YP_458309.1 COG2234 Predicted aminopeptidases YP_458310.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458311.1 COG2321 Predicted metalloprotease YP_458313.1 COG4219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component YP_458314.1 COG3682 Predicted transcriptional regulator YP_458316.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_458317.1 COG0740 Protease subunit of ATP-dependent Clp proteases YP_458320.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_458321.1 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit YP_458322.1 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit YP_458323.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458324.1 COG2827 Predicted endonuclease containing a URI domain YP_458325.1 COG2264 Ribosomal protein L11 methylase YP_458327.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_458328.1 COG4221 Short-chain alcohol dehydrogenase of unknown specificity YP_458330.1 COG1546 Uncharacterized protein (competence- and mitomycin-induced) YP_458331.1 COG2367 Beta-lactamase class A YP_458332.1 COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) YP_458333.1 COG2378 Predicted transcriptional regulator YP_458334.1 COG0497 ATPase involved in DNA repair YP_458335.1 COG4105 DNA uptake lipoprotein YP_458336.1 COG0263 Glutamate 5-kinase YP_458337.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_458338.1 COG1196 Chromosome segregation ATPases YP_458340.1 COG2801 Transposase and inactivated derivatives YP_458341.1 COG2801 Transposase and inactivated derivatives YP_458342.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_458344.1 COG2199 FOG: GGDEF domain YP_458345.1 COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain YP_458346.1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_458347.1 COG3243 Poly(3-hydroxyalkanoate) synthetase YP_458348.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458349.1 COG2270 Permeases of the major facilitator superfamily YP_458350.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458351.1 COG3653 N-acyl-D-aspartate/D-glutamate deacylase YP_458352.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458353.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_458355.1 binds the polymerase to DNA and acts as a sliding clamp YP_458356.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458357.1 COG0331 ACP S-malonyltransferase YP_458358.1 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_458359.1 COG0773 UDP-N-acetylmuramate-alanine ligase YP_458360.1 COG0625 Glutathione S-transferase YP_458361.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_458362.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_458363.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_458364.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_458365.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458367.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) YP_458368.1 COG4067 Uncharacterized protein conserved in archaea YP_458369.1 COG3391 Uncharacterized conserved protein YP_458371.1 COG1823 Predicted Na+/dicarboxylate symporter YP_458372.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458373.1 COG3917 2-hydroxychromene-2-carboxylate isomerase YP_458375.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_458376.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458377.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_458378.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_458379.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_458380.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_458381.1 COG0388 Predicted amidohydrolase YP_458383.1 COG0806 RimM protein, required for 16S rRNA processing YP_458384.1 COG0228 Ribosomal protein S16 YP_458385.1 COG0541 Signal recognition particle GTPase YP_458387.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_458388.1 COG0477 Permeases of the major facilitator superfamily YP_458389.1 COG0283 Cytidylate kinase YP_458390.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_458391.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_458392.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_458393.1 COG0711 F0F1-type ATP synthase, subunit b YP_458396.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_458398.1 COG3784 Uncharacterized protein conserved in bacteria YP_458400.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_458401.1 COG2003 DNA repair proteins YP_458402.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_458404.1 COG0284 Orotidine-5'-phosphate decarboxylase YP_458405.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_458406.1 COG0135 Phosphoribosylanthranilate isomerase YP_458407.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_458408.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_458409.1 COG0777 Acetyl-CoA carboxylase beta subunit YP_458410.1 COG0285 Folylpolyglutamate synthase YP_458411.1 COG0477 Permeases of the major facilitator superfamily YP_458412.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_458413.1 COG0742 N6-adenine-specific methylase YP_458416.1 COG3791 Uncharacterized conserved protein YP_458418.1 COG0210 Superfamily I DNA and RNA helicases YP_458419.1 COG2202 FOG: PAS/PAC domain YP_458420.1 COG0784 FOG: CheY-like receiver YP_458421.1 COG3000 Sterol desaturase YP_458422.1 COG0513 Superfamily II DNA and RNA helicases YP_458424.1 COG0277 FAD/FMN-containing dehydrogenases YP_458425.1 COG0180 Tryptophanyl-tRNA synthetase YP_458426.1 COG3741 N-formylglutamate amidohydrolase YP_458427.1 COG0784 FOG: CheY-like receiver YP_458428.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_458429.1 Converts isocitrate to alpha ketoglutarate YP_458430.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458431.1 COG0475 Kef-type K+ transport systems, membrane components YP_458433.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_458434.1 COG0500 SAM-dependent methyltransferases YP_458435.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_458436.1 COG0642 Signal transduction histidine kinase YP_458437.1 COG3216 Uncharacterized protein conserved in bacteria YP_458438.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_458439.1 COG3608 Predicted deacylase YP_458441.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_458442.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_458443.1 COG0782 Transcription elongation factor YP_458446.1 COG0820 Predicted Fe-S-cluster redox enzyme YP_458447.1 COG1073 Hydrolases of the alpha/beta superfamily YP_458448.1 COG0500 SAM-dependent methyltransferases YP_458449.1 COG0457 FOG: TPR repeat YP_458450.1 COG2258 Uncharacterized protein conserved in bacteria YP_458451.1 COG0531 Amino acid transporters YP_458453.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458454.1 COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) YP_458455.1 COG2041 Sulfite oxidase and related enzymes YP_458457.1 COG0776 Bacterial nucleoid DNA-binding protein YP_458458.1 COG2230 Cyclopropane fatty acid synthase and related methyltransferases YP_458459.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_458460.1 COG0797 Lipoproteins YP_458461.1 COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) YP_458464.1 COG2378 Predicted transcriptional regulator YP_458465.1 COG2801 Transposase and inactivated derivatives YP_458466.1 COG2801 Transposase and inactivated derivatives YP_458467.1 COG3593 Predicted ATP-dependent endonuclease of the OLD family YP_458468.1 COG0178 Excinuclease ATPase subunit YP_458469.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_458471.1 COG2199 FOG: GGDEF domain YP_458473.1 COG1846 Transcriptional regulators YP_458474.1 COG3772 Phage-related lysozyme (muraminidase) YP_458475.1 COG0339 Zn-dependent oligopeptidases YP_458477.1 COG3409 peptidoglycan-binding domain-containing protein YP_458478.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase component YP_458479.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component YP_458480.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_458481.1 COG4206 Outer membrane cobalamin receptor protein YP_458482.1 COG3773 Cell wall hydrolyses involved in spore germination YP_458484.1 COG2199 FOG: GGDEF domain YP_458485.1 COG0039 Malate/lactate dehydrogenases YP_458487.1 COG0074 Succinyl-CoA synthetase, alpha subunit YP_458488.1 COG2827 Predicted endonuclease containing a URI domain YP_458489.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_458490.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_458491.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_458492.1 COG3565 Predicted dioxygenase of extradiol dioxygenase family YP_458493.1 COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases YP_458495.1 COG0772 Bacterial cell division membrane protein YP_458496.1 COG2860 Predicted membrane protein YP_458497.1 COG2182 Maltose-binding periplasmic proteins/domains YP_458499.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_458500.1 is a component of the macrolide binding site in the peptidyl transferase center YP_458501.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_458502.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_458503.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_458505.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_458506.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_458507.1 late assembly protein YP_458508.1 COG4663 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component YP_458509.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_458510.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_458511.1 binds 5S rRNA along with protein L5 and L25 YP_458512.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_458513.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_458514.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_458515.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_458516.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_458517.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_458518.1 COG0186 Ribosomal protein S17 YP_458519.1 one of the stabilizing components for the large ribosomal subunit YP_458520.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_458521.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_458522.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_458523.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_458524.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_458525.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_458526.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_458527.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_458528.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_458529.1 COG0500 SAM-dependent methyltransferases YP_458530.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_458531.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_458532.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_458533.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_458534.1 COG1475 Predicted transcriptional regulators YP_458535.1 COG0338 Site-specific DNA methylase YP_458537.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458538.1 COG0583 Transcriptional regulator YP_458539.1 protein associated with Co2+ and Mg2+ efflux YP_458541.1 COG4961 Flp pilus assembly protein TadG YP_458542.1 COG4961 Flp pilus assembly protein TadG YP_458543.1 COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase YP_458544.1 COG3917 2-hydroxychromene-2-carboxylate isomerase YP_458545.1 COG1285 Uncharacterized membrane protein YP_458547.1 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases YP_458549.1 COG1309 Transcriptional regulator YP_458550.1 COG0477 Permeases of the major facilitator superfamily YP_458554.1 COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase YP_458555.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_458556.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_458559.1 COG2960 Uncharacterized protein conserved in bacteria YP_458560.1 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) YP_458561.1 COG1189 Predicted rRNA methylase YP_458563.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_458564.1 COG1054 Predicted sulfurtransferase YP_458565.1 COG0625 Glutathione S-transferase YP_458566.1 COG0583 Transcriptional regulator YP_458567.1 COG1741 Pirin-related protein YP_458568.1 COG1182 ACP phosphodiesterase YP_458569.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_458570.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_458571.1 COG3569 topoisomeraseIB YP_458572.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli YP_458573.1 COG2211 Na+/melibiose symporter and related transporters YP_458574.1 COG3577 Predicted aspartyl protease YP_458575.1 COG3380 Predicted NAD/FAD-dependent oxidoreductase YP_458577.1 COG4301 Uncharacterized conserved protein YP_458578.1 COG1262 Uncharacterized conserved protein YP_458579.1 COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase YP_458580.1 COG0612 Predicted Zn-dependent peptidases YP_458581.1 COG0694 Thioredoxin-like proteins and domains YP_458582.1 COG0778 Nitroreductase YP_458583.1 COG1214 Inactive homolog of metal-dependent proteases, molecular chaperone YP_458584.1 COG0456 acetyltransferases YP_458585.1 COG0735 Fe2+/Zn2+ uptake regulation proteins YP_458586.1 COG0735 Fe2+/Zn2+ uptake regulation proteins YP_458587.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_458588.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_458589.1 COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase YP_458590.1 COG0319 Predicted metal-dependent hydrolase YP_458591.1 COG1253 Hemolysins and related proteins containing CBS domains YP_458592.1 COG0583 Transcriptional regulator YP_458594.1 COG2267 Lysophospholipase YP_458595.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_458596.1 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) YP_458597.1 COG1878 Predicted metal-dependent hydrolase YP_458600.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458601.1 COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis YP_458602.1 COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding YP_458603.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_458604.1 COG0730 Predicted permeases YP_458605.1 COG1194 A/G-specific DNA glycosylase YP_458607.1 COG1651 Protein-disulfide isomerase YP_458608.1 COG1651 Protein-disulfide isomerase YP_458609.1 COG1196 Chromosome segregation ATPases YP_458610.1 COG0789 Predicted transcriptional regulators YP_458611.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_458613.1 COG0332 3-oxoacyl-ACP synthase III YP_458614.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_458615.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_458616.1 COG3788 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily YP_458617.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_458619.1 COG2932 Predicted transcriptional regulator YP_458622.1 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_458623.1 COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases YP_458624.1 COG3751 Predicted proline hydroxylase YP_458625.1 COG5654 Uncharacterized conserved protein YP_458626.1 COG0215 Cysteinyl-tRNA synthetase YP_458627.1 COG0778 Nitroreductase YP_458629.1 COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) YP_458630.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_458632.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_458633.1 COG0625 Glutathione S-transferase YP_458634.1 COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase YP_458635.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_458637.1 COG0251 translation initiation inhibitor, yjgF family YP_458638.1 contains: methylated-dna--protein-cysteine methyltransferase; COG2169 Adenosine deaminase YP_458639.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_458641.1 COG2175 Probable taurine catabolism dioxygenase YP_458642.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_458643.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_458644.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_458646.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_458647.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_458648.1 COG1505 Serine proteases of the peptidase family S9A YP_458650.1 COG1403 Restriction endonuclease YP_458652.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_458653.1 COG0546 Predicted phosphatases YP_458654.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458656.1 COG1045 Serine acetyltransferase YP_458657.1 COG0593 ATPase involved in DNA replication initiation YP_458659.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_458660.1 COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN YP_458661.1 COG0105 Nucleoside diphosphate kinase YP_458663.1 COG2927 DNA polymerase III, chi subunit YP_458664.1 COG4338 Uncharacterized protein conserved in bacteria YP_458665.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_458666.1 COG1452 Organic solvent tolerance protein OstA YP_458667.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_458668.1 COG1995 Pyridoxal phosphate biosynthesis protein YP_458669.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_458670.1 COG3108 Uncharacterized protein conserved in bacteria YP_458671.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_458672.1 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases YP_458673.1 COG3138 Arginine/ornithine N-succinyltransferase beta subunit YP_458674.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_458676.1 COG1970 Large-conductance mechanosensitive channel YP_458677.1 COG1704 Uncharacterized conserved protein YP_458678.1 COG1512 Beta-propeller domains of methanol dehydrogenase type YP_458679.1 COG1512 Beta-propeller domains of methanol dehydrogenase type YP_458680.1 COG3762 Predicted membrane protein YP_458681.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_458682.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458683.1 COG1983 stress-responsive transcriptional regulator YP_458687.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_458688.1 COG2755 Lysophospholipase L1 and related esterases YP_458689.1 COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component YP_458690.1 COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component YP_458691.1 COG3152 Predicted membrane protein YP_458692.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_458693.1 COG1217 Predicted membrane GTPase involved in stress response YP_458694.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_458695.1 COG3919 Predicted ATP-grasp enzyme YP_458696.1 COG0591 Na+/proline symporter YP_458697.1 COG0346 Lactoylglutathione lyase and related lyases YP_458698.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458699.1 COG3921 Uncharacterized protein conserved in bacteria YP_458700.1 COG4566 Response regulator YP_458701.1 COG3484 Predicted proteasome-type protease YP_458702.1 COG1305 Transglutaminase-like enzymes, cysteine proteases YP_458703.1 COG2307 Uncharacterized protein conserved in bacteria YP_458704.1 COG2308 Uncharacterized conserved protein YP_458705.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_458709.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_458710.1 COG2801 Transposase and inactivated derivatives YP_458711.1 COG2801 Transposase and inactivated derivatives YP_458712.1 COG1724 Predicted periplasmic or secreted lipoprotein YP_458713.1 COG1598 Uncharacterized conserved protein YP_458714.1 COG0056 F0F1-type ATP synthase, alpha subunit YP_458716.1 COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis YP_458717.1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases YP_458719.1 COG1587 Uroporphyrinogen-III synthase YP_458720.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_458721.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_458722.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_458723.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_458724.1 COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain YP_458725.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_458728.1 COG0784 FOG: CheY-like receiver YP_458729.1 COG1960 Acyl-CoA dehydrogenases YP_458730.1 COG0625 Glutathione S-transferase YP_458731.1 COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) YP_458732.1 COG2323 Predicted membrane protein YP_458733.1 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_458734.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_458735.1 COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A YP_458736.1 COG1960 Acyl-CoA dehydrogenases YP_458737.1 COG1960 Acyl-CoA dehydrogenases YP_458739.1 COG3817 Predicted membrane protein YP_458740.1 COG3819 Predicted membrane protein YP_458741.1 COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit YP_458742.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_458746.1 COG3497 Phage tail sheath protein FI YP_458748.1 COG3497 Phage tail sheath protein FI YP_458749.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_458750.1 COG1652 Uncharacterized protein containing LysM domain YP_458752.1 COG3500 Phage protein D YP_458753.1 COG3501 Uncharacterized protein conserved in bacteria YP_458755.1 COG3628 Phage baseplate assembly protein W YP_458757.1 COG1874 Beta-galactosidase YP_458759.1 COG2987 Urocanate hydratase YP_458763.1 COG0464 ATPases of the AAA+ class YP_458766.1 COG0495 Leucyl-tRNA synthetase YP_458767.1 COG3824 Uncharacterized protein conserved in bacteria YP_458768.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_458770.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_458771.1 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily YP_458772.1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases YP_458773.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_458774.1 COG1407 Predicted ICC-like phosphoesterases YP_458775.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_458776.1 COG1171 Threonine dehydratase YP_458778.1 COG0465 ATP-dependent Zn proteases YP_458779.1 COG3039 Transposase and inactivated derivatives, IS5 family YP_458780.1 COG0471 Di- and tricarboxylate transporters YP_458783.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_458784.1 catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine YP_458785.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_458786.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458787.1 COG2303 Choline dehydrogenase and related flavoproteins YP_458789.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_458790.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_458793.1 COG0848 Biopolymer transport protein YP_458795.1 COG0811 Biopolymer transport proteins YP_458796.1 COG0824 Predicted thioesterase YP_458797.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_458798.1 COG2314 Predicted membrane protein YP_458799.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_458800.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_458801.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_458802.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_458803.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_458804.1 COG3814 Uncharacterized protein conserved in bacteria YP_458806.1 Essential for recycling GMP and indirectly, cGMP YP_458807.1 COG3239 Fatty acid desaturase YP_458808.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458809.1 COG1960 Acyl-CoA dehydrogenases YP_458810.1 COG1960 Acyl-CoA dehydrogenases YP_458811.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458812.1 COG2211 Na+/melibiose symporter and related transporters YP_458813.1 COG1960 Acyl-CoA dehydrogenases YP_458814.1 COG1062 Zn-dependent alcohol dehydrogenases, class III YP_458815.1 COG3173 Predicted aminoglycoside phosphotransferase YP_458816.1 COG1404 Subtilisin-like serine proteases YP_458817.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_458822.1 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog YP_458823.1 COG4270 Predicted membrane protein YP_458824.1 COG5531 SWIB-domain-containing proteins implicated in chromatin remodeling YP_458825.1 COG1881 Phospholipid-binding protein YP_458826.1 COG0793 Periplasmic protease YP_458827.1 COG4323 Predicted membrane protein YP_458828.1 COG2335 Secreted and surface protein containing fasciclin-like repeats YP_458829.1 COG2343 Uncharacterized protein conserved in bacteria YP_458830.1 COG3650 Predicted membrane protein YP_458831.1 COG3791 Uncharacterized conserved protein YP_458833.1 COG0657 Esterase/lipase YP_458834.1 COG0415 Deoxyribodipyrimidine photolyase YP_458836.1 COG0051 Ribosomal protein S10 YP_458841.1 COG3871 Uncharacterized stress protein (general stress protein 26) YP_458843.1 COG1278 Cold shock proteins YP_458844.1 COG1671 Uncharacterized protein conserved in bacteria YP_458849.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_458850.1 COG0477 Permeases of the major facilitator superfamily YP_458851.1 COG5126 Ca2+-binding protein (EF-Hand superfamily) YP_458852.1 COG2124 Cytochrome P450 YP_458853.1 COG0625 Glutathione S-transferase YP_458854.1 COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_458855.1 COG2072 Predicted flavoprotein involved in K+ transport YP_458856.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_458857.1 COG5295 Autotransporter adhesin YP_458858.1 COG2217 Cation transport ATPase YP_458859.1 COG4805 Uncharacterized protein conserved in bacteria YP_458860.1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I YP_458861.1 COG1228 Imidazolonepropionase and related amidohydrolases YP_458862.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_458864.1 COG3713 Outer membrane protein V YP_458866.1 COG1233 Phytoene dehydrogenase and related proteins YP_458867.1 COG1611 Predicted Rossmann fold nucleotide-binding protein YP_458868.1 COG1562 Phytoene/squalene synthetase YP_458869.1 COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit YP_458870.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_458871.1 COG0477 Permeases of the major facilitator superfamily YP_458872.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_458873.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_458874.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase YP_458875.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) YP_458877.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458879.1 COG2855 Predicted membrane protein YP_458880.1 COG0500 SAM-dependent methyltransferases YP_458881.1 COG2303 Choline dehydrogenase and related flavoproteins YP_458882.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_458883.1 COG0789 Predicted transcriptional regulators YP_458885.1 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_458887.1 COG0582 Integrase YP_458888.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_458893.1 COG0251 translation initiation inhibitor, yjgF family YP_458894.1 COG1960 Acyl-CoA dehydrogenases YP_458895.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_458896.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_458898.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_458899.1 COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase YP_458900.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_458901.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_458902.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_458903.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_458904.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_458905.1 COG1410 Methionine synthase I, cobalamin-binding domain YP_458906.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458907.1 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain YP_458908.1 COG0685 5,10-methylenetetrahydrofolate reductase YP_458909.1 COG0640 Predicted transcriptional regulators YP_458910.1 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) YP_458918.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_458919.1 COG2003 DNA repair proteins YP_458921.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_458922.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_458923.1 COG0436 Aspartate/tyrosine/aromatic aminotransferase YP_458924.1 COG3243 Poly(3-hydroxyalkanoate) synthetase YP_458925.1 COG0216 Protein chain release factor A YP_458926.1 COG2127 Uncharacterized conserved protein YP_458927.1 COG0795 Predicted permeases YP_458928.1 COG0795 Predicted permeases YP_458929.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458932.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_458933.1 contains transmitterdomain, similar to ExsG protein; COG3614 Predicted periplasmic ligand-binding sensor domain YP_458935.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_458936.1 COG0605 Superoxide dismutase YP_458937.1 COG1301 Na+/H+-dicarboxylate symporters YP_458938.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_458939.1 COG3813 Uncharacterized protein conserved in bacteria YP_458940.1 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase YP_458941.1 COG1611 Predicted Rossmann fold nucleotide-binding protein YP_458942.1 COG3182 Uncharacterized iron-regulated membrane protein YP_458944.1 COG0248 Exopolyphosphatase YP_458945.1 COG0293 23S rRNA methylase YP_458946.1 COG3474 Cytochrome c2 YP_458947.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_458949.1 COG0488 ATPase component of ABC transporters with duplicated ATPase domains YP_458950.1 COG0714 MoxR-like ATPases YP_458951.1 COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) YP_458952.1 COG1300 Uncharacterized membrane protein YP_458953.1 COG1714 Predicted membrane protein/domain YP_458954.1 COG3239 Fatty acid desaturase YP_458955.1 COG1446 Asparaginase YP_458956.1 COG0668 Small-conductance mechanosensitive channel YP_458957.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_458958.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_458959.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_458961.1 COG0598 Mg2+ and Co2+ transporters YP_458962.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_458964.1 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein YP_458965.1 COG0644 Dehydrogenases (flavoproteins) YP_458967.1 COG2989 Uncharacterized protein conserved in bacteria YP_458968.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_458969.1 COG1048 Aconitase A YP_458970.1 COG0607 Rhodanese-related sulfurtransferase YP_458974.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_458975.1 COG2827 Predicted endonuclease containing a URI domain YP_458977.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_458978.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_458979.1 COG0450 Peroxiredoxin YP_458980.1 COG3634 Alkyl hydroperoxide reductase, large subunit YP_458982.1 COG0376 Catalase (peroxidase I) YP_458984.1 COG3279 Response regulator of the LytR/AlgR family YP_458986.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_458987.1 COG2821 Membrane-bound lytic murein transglycosylase YP_458988.1 COG4395 Uncharacterized protein conserved in bacteria YP_458989.1 COG1952 Preprotein translocase subunit SecB YP_458990.1 COG0728 Uncharacterized membrane protein, virulence factor YP_458991.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_458992.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_458994.1 COG0756 dUTPase YP_458995.1 COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase YP_458998.1 COG0661 Predicted unusual protein kinase YP_458999.1 COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis YP_459000.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_459001.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_459002.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_459003.1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 YP_459004.1 COG0554 Glycerol kinase YP_459005.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_459006.2 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_459007.1 COG0177 Predicted EndoIII-related endonuclease YP_459009.1 COG1301 Na+/H+-dicarboxylate symporters YP_459010.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_459011.1 COG3837 Uncharacterized conserved protein, contains double-stranded beta-helix domain YP_459013.1 COG0625 Glutathione S-transferase YP_459014.1 COG0657 Esterase/lipase YP_459015.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_459016.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_459017.1 COG0759 Uncharacterized conserved protein YP_459018.1 COG0594 RNase P protein component YP_459020.1 COG0606 Predicted ATPase with chaperone activity YP_459021.1 COG2801 Transposase and inactivated derivatives YP_459022.1 COG2963 Transposase and inactivated derivatives YP_459024.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459025.1 COG1878 Predicted metal-dependent hydrolase YP_459026.1 COG3246 Uncharacterized conserved protein YP_459027.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459029.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_459030.1 COG2303 Choline dehydrogenase and related flavoproteins YP_459031.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_459032.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_459033.1 COG0183 Acetyl-CoA acetyltransferase YP_459034.1 COG1960 Acyl-CoA dehydrogenases YP_459035.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459036.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459037.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459039.1 COG0583 Transcriptional regulator YP_459041.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_459042.1 COG0640 Predicted transcriptional regulators YP_459043.1 COG2801 Transposase and inactivated derivatives YP_459044.1 COG2801 Transposase and inactivated derivatives YP_459045.1 COG0701 Predicted permeases YP_459047.1 COG3464 Transposase and inactivated derivatives YP_459048.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_459049.1 COG0477 Permeases of the major facilitator superfamily YP_459050.1 COG4206 Outer membrane cobalamin receptor protein YP_459054.1 COG0582 Integrase YP_459055.1 COG2059 Chromate transport protein ChrA YP_459056.1 COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit YP_459057.1 COG0661 Predicted unusual protein kinase YP_459060.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_459061.1 COG2801 Transposase and inactivated derivatives YP_459064.1 COG0171 NAD synthase YP_459066.1 COG0606 Predicted ATPase with chaperone activity YP_459069.1 COG3861 Uncharacterized protein conserved in bacteria YP_459071.1 COG1733 Predicted transcriptional regulators YP_459073.1 COG1011 Predicted hydrolase (HAD superfamily) YP_459074.1 COG0257 Ribosomal protein L36 YP_459075.1 COG1087 UDP-glucose 4-epimerase YP_459077.1 COG2866 Predicted carboxypeptidase YP_459078.1 COG3021 Uncharacterized protein conserved in bacteria YP_459079.1 COG0295 Cytidine deaminase YP_459080.1 COG2827 Predicted endonuclease containing a URI domain YP_459081.1 COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_459083.1 unwinds double stranded DNA YP_459084.1 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_459085.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_459086.1 COG1192 ATPases involved in chromosome partitioning YP_459087.1 COG3000 Sterol desaturase YP_459091.1 COG0465 ATP-dependent Zn proteases YP_459092.1 COG1309 Transcriptional regulator YP_459094.1 COG0591 Na+/proline symporter YP_459095.1 COG1309 Transcriptional regulator YP_459096.1 COG0577 ABC-type antimicrobial peptide transport system, permease component YP_459097.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_459098.1 COG0845 Membrane-fusion protein YP_459099.1 COG1538 Outer membrane protein YP_459101.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_459104.1 COG1960 Acyl-CoA dehydrogenases YP_459105.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_459106.1 COG0457 FOG: TPR repeat YP_459107.1 COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin YP_459108.1 COG0250 Transcription antiterminator YP_459109.1 COG0690 Preprotein translocase subunit SecE YP_459110.1 COG1115 Na+/alanine symporter YP_459111.1 COG0739 Membrane proteins related to metalloendopeptidases YP_459113.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_459114.1 COG4765 Uncharacterized protein conserved in bacteria YP_459115.1 Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone, to the generation of a proton gradient which is then used for ATP synthesis YP_459116.1 COG1430 Uncharacterized conserved protein YP_459117.1 COG2137 Uncharacterized protein conserved in bacteria YP_459118.1 activates fatty acids by binding to coenzyme A YP_459120.1 COG3853 Uncharacterized protein involved in tellurite resistance YP_459121.1 COG1196 Chromosome segregation ATPases YP_459122.1 COG0425 Predicted redox protein, regulator of disulfide bond formation YP_459124.1 COG4771 Outer membrane receptor for ferrienterochelin and colicins YP_459125.1 COG3491 Isopenicillin N synthase and related dioxygenases YP_459126.1 COG1972 Nucleoside permease YP_459127.1 COG1738 Uncharacterized conserved protein YP_459128.1 COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain YP_459129.1 COG2199 FOG: GGDEF domain YP_459130.1 COG0823 Periplasmic component of the Tol biopolymer transport system YP_459131.1 COG2068 Uncharacterized MobA-related protein YP_459132.1 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family YP_459133.1 COG3474 Cytochrome c2 YP_459134.1 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs YP_459135.1 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs YP_459136.1 COG0840 Methyl-accepting chemotaxis protein YP_459137.1 COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain YP_459138.1 COG1352 Methylase of chemotaxis methyl-accepting proteins YP_459139.1 COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain YP_459140.1 COG0784 FOG: CheY-like receiver YP_459141.1 COG0835 Chemotaxis signal transduction protein YP_459142.1 COG0643 Chemotaxis protein histidine kinase and related kinases YP_459143.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_459144.1 COG0388 Predicted amidohydrolase YP_459145.1 COG2968 Uncharacterized conserved protein YP_459146.1 COG4798 Predicted methyltransferase YP_459147.1 COG0225 Peptide methionine sulfoxide reductase YP_459148.1 COG0144 tRNA and rRNA cytosine-C5-methylases YP_459149.1 COG5508 Uncharacterized conserved small protein YP_459151.1 COG2124 Cytochrome P450 YP_459152.1 COG0276 Protoheme ferro-lyase (ferrochelatase) YP_459153.1 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs YP_459154.1 COG0489 ATPases involved in chromosome partitioning YP_459155.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_459156.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_459157.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_459158.1 COG0744 Membrane carboxypeptidase (penicillin-binding protein) YP_459159.1 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase YP_459160.1 COG0625 Glutathione S-transferase YP_459163.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_459164.1 COG1062 Zn-dependent alcohol dehydrogenases, class III YP_459165.1 COG0662 Mannose-6-phosphate isomerase YP_459166.1 COG0346 Lactoylglutathione lyase and related lyases YP_459167.1 COG0346 Lactoylglutathione lyase and related lyases YP_459168.1 COG3760 Uncharacterized conserved protein YP_459169.1 COG0627 Predicted esterase YP_459170.1 COG0500 SAM-dependent methyltransferases YP_459171.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_459172.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_459173.1 dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate YP_459174.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_459175.1 COG1434 Uncharacterized conserved protein YP_459177.1 COG2884 Predicted ATPase involved in cell division YP_459179.1 COG3752 Predicted membrane protein YP_459181.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459182.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_459183.1 COG0104 Adenylosuccinate synthase YP_459184.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_459185.1 COG1946 Acyl-CoA thioesterase YP_459186.1 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_459187.1 COG1960 Acyl-CoA dehydrogenases YP_459188.1 COG3268 Uncharacterized conserved protein YP_459189.1 COG2259 Predicted membrane protein YP_459190.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459191.1 COG3118 Thioredoxin domain-containing protein YP_459192.1 COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease YP_459193.1 COG2095 Multiple antibiotic transporter YP_459195.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_459196.1 COG0762 Predicted integral membrane protein YP_459197.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_459201.1 COG1525 Micrococcal nuclease (thermonuclease) homologs YP_459205.1 COG2852 Uncharacterized protein conserved in bacteria YP_459206.1 COG3326 Predicted membrane protein YP_459209.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_459211.1 COG3798 Uncharacterized protein conserved in bacteria YP_459212.1 COG2610 H+/gluconate symporter and related permeases YP_459215.1 COG2852 Uncharacterized protein conserved in bacteria YP_459216.1 Catalyzes the rate-limiting step in dNTP synthesis YP_459218.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_459219.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_459221.1 COG0029 Aspartate oxidase YP_459223.1 COG0500 SAM-dependent methyltransferases YP_459224.1 COG1131 ABC-type multidrug transport system, ATPase component YP_459225.1 COG4391 Uncharacterized protein conserved in bacteria YP_459226.1 COG1219 ATP-dependent protease Clp, ATPase subunit YP_459227.1 COG3803 Uncharacterized protein conserved in bacteria YP_459228.1 COG0177 Predicted EndoIII-related endonuclease YP_459229.1 COG0177 Predicted EndoIII-related endonuclease YP_459230.1 COG0457 FOG: TPR repeat YP_459231.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_459233.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_459234.1 COG2120 Uncharacterized proteins, LmbE homologs YP_459235.1 COG0187 Type IIA topoisomerase(DNA gyrase/topo II, topoisomeraseIV), B subunit YP_459236.1 COG1994 Zn-dependent proteases YP_459237.1 COG0628 Predicted permease YP_459238.1 COG2081 Predicted flavoproteins YP_459239.1 COG1309 Transcriptional regulator YP_459240.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_459242.1 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) YP_459243.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_459244.1 COG0477 Permeases of the major facilitator superfamily YP_459245.1 COG3196 Uncharacterized protein conserved in bacteria YP_459246.1 COG1960 Acyl-CoA dehydrogenases YP_459247.1 COG2203 FOG: GAF domain YP_459248.1 COG1125 ABC-type proline/glycine betaine transport systems, ATPase component YP_459249.1 COG1174 ABC-type proline/glycine betaine transport systems, permease component YP_459250.1 COG4731 Uncharacterized protein conserved in bacteria YP_459251.1 COG1565 Uncharacterized conserved protein YP_459252.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_459253.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_459254.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_459255.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_459256.1 COG0325 Predicted enzyme with a TIM-barrel fold YP_459257.1 COG0352 Thiamine monophosphate synthase YP_459258.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_459259.1 COG4929 Uncharacterized membrane-anchored protein YP_459261.1 COG1808 Predicted membrane protein YP_459262.1 COG0226 ABC-type phosphate transport system, periplasmic component YP_459263.1 COG3746 Phosphate-selective porin YP_459264.1 COG0686 Alanine dehydrogenase YP_459265.1 COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_459266.1 COG0824 Predicted thioesterase YP_459267.1 COG1011 Predicted hydrolase (HAD superfamily) YP_459268.1 COG1770 Protease II YP_459269.1 COG0006 Xaa-Pro aminopeptidase YP_459270.1 COG0346 Lactoylglutathione lyase and related lyases YP_459273.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_459274.1 COG0642 Signal transduction histidine kinase YP_459275.1 COG0625 Glutathione S-transferase YP_459276.1 COG0433 Predicted ATPase YP_459277.1 COG0147 Anthranilate/para-aminobenzoate synthases component I YP_459278.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_459279.1 COG1186 Protein chain release factor B YP_459280.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_459281.1 COG2834 Outer membrane lipoprotein-sorting protein YP_459282.1 COG1785 Alkaline phosphatase YP_459283.1 COG0708 Exonuclease III YP_459284.1 COG0807 GTP cyclohydrolase II YP_459285.1 COG3153 Predicted acetyltransferase YP_459286.1 COG0688 Phosphatidylserine decarboxylase YP_459290.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_459291.1 COG0514 Superfamily II DNA helicase YP_459294.1 COG1960 Acyl-CoA dehydrogenases YP_459295.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_459296.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_459297.1 COG3777 Uncharacterized conserved protein YP_459298.1 COG2326 Uncharacterized conserved protein YP_459299.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_459301.1 COG2261 Predicted membrane protein YP_459302.1 COG1968 Uncharacterized bacitracin resistance protein YP_459303.1 COG3590 Predicted metalloendopeptidase YP_459304.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_459305.1 COG4553 Poly-beta-hydroxyalkanoate depolymerase YP_459307.1 COG0183 Acetyl-CoA acetyltransferase YP_459308.1 COG2030 Acyl dehydratase YP_459309.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_459310.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_459312.1 COG0438 Glycosyltransferase YP_459313.1 COG1530 Ribonucleases G and E YP_459314.1 COG0067 Glutamate synthase domain 1 YP_459315.1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_459317.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_459318.1 COG1024 Enoyl-CoA hydratase/carnithine racemase YP_459319.1 COG1734 DnaK suppressor protein YP_459320.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_459321.1 COG0349 Ribonuclease D YP_459323.1 COG1934 Uncharacterized protein conserved in bacteria YP_459325.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_459327.1 COG1596 Periplasmic protein involved in polysaccharide export YP_459328.1 COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis YP_459330.1 COG0110 acetyltransferase (isoleucine patch superfamily) YP_459332.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_459333.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_459336.1 COG0438 Glycosyltransferase YP_459337.1 COG0477 Permeases of the major facilitator superfamily YP_459338.1 COG0438 Glycosyltransferase YP_459340.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis YP_459341.1 COG1466 DNA polymerase III, delta subunit YP_459344.1 COG2025 Electron transfer flavoprotein, alpha subunit YP_459345.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459346.1 COG2771 DNA-binding HTH domain-containing proteins YP_459348.1 COG4321 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis YP_459349.1 COG0456 acetyltransferases YP_459350.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_459351.1 COG1210 UDP-glucose pyrophosphorylase YP_459352.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459353.1 COG2124 Cytochrome P450 YP_459354.1 activates fatty acids by binding to coenzyme A YP_459355.1 COG0739 Membrane proteins related to metalloendopeptidases YP_459356.1 COG1225 Peroxiredoxin YP_459357.1 COG1391 Glutamine synthetase adenylyltransferase YP_459358.1 COG2234 Predicted aminopeptidases YP_459359.1 COG2957 Peptidylarginine deiminase and related enzymes YP_459361.1 COG5429 Uncharacterized secreted protein YP_459363.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_459364.1 COG2213 Phosphotransferase system, mannitol-specific IIBC component YP_459365.1 COG3540 Phosphodiesterase/alkaline phosphatase D YP_459367.1 COG0477 Permeases of the major facilitator superfamily YP_459368.1 COG1476 Predicted transcriptional regulators YP_459369.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_459370.1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_459371.1 COG2902 NAD-specific glutamate dehydrogenase YP_459372.1 COG2902 NAD-specific glutamate dehydrogenase YP_459373.1 COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases YP_459374.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_459375.1 COG1600 Uncharacterized Fe-S protein YP_459376.1 COG4152 ABC-type uncharacterized transport system, ATPase component YP_459377.1 COG1668 ABC-type Na+ efflux pump, permease component YP_459378.1 COG2124 Cytochrome P450 YP_459379.1 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase YP_459380.1 COG0477 Permeases of the major facilitator superfamily YP_459381.1 COG2246 Predicted membrane protein YP_459382.1 COG1232 Protoporphyrinogen oxidase YP_459384.1 COG0776 Bacterial nucleoid DNA-binding protein YP_459385.1 COG1725 Predicted transcriptional regulators YP_459386.1 COG3104 Dipeptide/tripeptide permease YP_459387.1 COG1228 Imidazolonepropionase and related amidohydrolases YP_459388.1 COG1228 Imidazolonepropionase and related amidohydrolases YP_459389.1 COG0531 Amino acid transporters YP_459390.1 COG1733 Predicted transcriptional regulators YP_459391.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_459392.1 COG1073 Hydrolases of the alpha/beta superfamily YP_459393.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_459394.1 COG0735 Fe2+/Zn2+ uptake regulation proteins YP_459395.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_459397.1 involved in de novo purine biosynthesis YP_459399.1 COG0036 Pentose-5-phosphate-3-epimerase YP_459402.1 COG0367 Asparagine synthase (glutamine-hydrolyzing) YP_459403.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_459404.1 COG4704 Uncharacterized protein conserved in bacteria YP_459406.1 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_459407.1 activates fatty acids by binding to coenzyme A YP_459411.1 COG3000 Sterol desaturase YP_459412.1 COG4704 Uncharacterized protein conserved in bacteria YP_459414.1 COG4850 Uncharacterized conserved protein YP_459415.1 COG0657 Esterase/lipase YP_459416.1 COG4783 Zn-dependent protease, contains TPR repeats YP_459417.1 COG1651 Protein-disulfide isomerase YP_459418.1 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_459419.1 COG4341 Predicted HD phosphohydrolase YP_459420.1 COG2972 Predicted signal transduction protein with a C-terminal ATPase domain YP_459421.1 COG3279 Response regulator of the LytR/AlgR family YP_459422.1 COG1012 NAD-dependent aldehyde dehydrogenases YP_459423.1 COG0157 Nicotinate-nucleotide pyrophosphorylase YP_459424.1 COG3719 Ribonuclease I YP_459426.1 COG0590 Cytosine/adenosine deaminases YP_459427.1 required for 70S ribosome assembly YP_459429.1 COG0739 Membrane proteins related to metalloendopeptidases YP_459431.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_459432.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_459433.1 COG0524 Sugar kinases, ribokinase family YP_459437.1 COG0316 Uncharacterized conserved protein YP_459438.1 COG2151 Predicted metal-sulfur cluster biosynthetic enzyme YP_459439.1 COG0520 Selenocysteine lyase YP_459440.1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component YP_459441.1 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component YP_459444.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) YP_459445.1 COG0441 Threonyl-tRNA synthetase YP_459446.1 with SufCD activates cysteine desulfurase SufS YP_459447.1 COG1959 Predicted transcriptional regulator YP_459448.1 COG0180 Tryptophanyl-tRNA synthetase YP_459449.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_459450.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_459451.1 COG4805 Uncharacterized protein conserved in bacteria YP_459452.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_459453.1 COG0405 Gamma-glutamyltransferase YP_459454.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) YP_459457.1 fusion of thiS and thiG; functions in thiamine (vitamin B1) biosynthesis YP_459459.1 COG1612 Uncharacterized protein required for cytochrome oxidase assembly YP_459460.1 COG1324 Uncharacterized protein involved in tolerance to divalent cations YP_459461.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_459462.1 forms a direct contact with the tRNA during translation YP_459463.1 COG1409 Predicted phosphohydrolases YP_459464.1 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_459468.1 COG3279 Response regulator of the LytR/AlgR family YP_459469.1 COG2972 Predicted signal transduction protein with a C-terminal ATPase domain YP_459470.1 COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain YP_459471.1 COG2518 Protein-L-isoaspartate carboxylmethyltransferase YP_459472.1 COG1538 Outer membrane protein YP_459473.1 COG3827 Uncharacterized protein conserved in bacteria YP_459474.1 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases YP_459475.1 COG3411 Ferredoxin YP_459476.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component YP_459477.1 COG0517 FOG: CBS domain YP_459478.1 COG0316 Uncharacterized conserved protein YP_459479.1 COG0708 Exonuclease III YP_459480.1 COG3773 Cell wall hydrolyses involved in spore germination YP_459482.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_459483.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_459484.1 COG1544 Ribosome-associated protein Y (PSrp-1) YP_459485.1 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases YP_459486.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_459487.1 COG0169 Shikimate 5-dehydrogenase YP_459488.1 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation YP_459489.1 COG1806 Uncharacterized protein conserved in bacteria YP_459490.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_459491.1 COG1981 Predicted membrane protein YP_459492.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_459493.1 COG3911 Predicted ATPase YP_459494.1 COG2202 FOG: PAS/PAC domain YP_459496.1 COG0069 Glutamate synthase domain 2 YP_459497.1 COG0412 Dienelactone hydrolase and related enzymes YP_459499.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_459500.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_459501.1 COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division YP_459502.1 COG1192 ATPases involved in chromosome partitioning YP_459503.1 COG1475 Predicted transcriptional regulators YP_459505.1 COG1956 GAF domain-containing protein YP_459506.1 COG2133 Glucose/sorbosone dehydrogenases YP_459507.1 COG2607 Predicted ATPase (AAA+ superfamily) YP_459508.1 COG1960 Acyl-CoA dehydrogenases YP_459509.1 COG0009 translation factor (SUA5) YP_459511.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_459512.1 COG1329 Transcriptional regulators, similar to M. xanthus CarD YP_459513.1 COG1295 Predicted membrane protein YP_459514.1 COG1146 Ferredoxin YP_459515.1 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_459516.1 COG0513 Superfamily II DNA and RNA helicases YP_459517.1 COG0739 Membrane proteins related to metalloendopeptidases YP_459518.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_459519.1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_459520.1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins YP_459521.1 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_459522.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA YP_459523.1 COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing YP_459524.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_459526.1 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_459527.1 COG0625 Glutathione S-transferase YP_459528.1 COG2908 Uncharacterized protein conserved in bacteria YP_459529.1 COG0438 Glycosyltransferase YP_459530.1 COG3820 Uncharacterized protein conserved in bacteria YP_459531.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_459532.1 COG1664 Integral membrane protein CcmA involved in cell shape determination YP_459533.1 COG0739 Membrane proteins related to metalloendopeptidases YP_459534.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_459535.1 COG0799 Uncharacterized homolog of plant Iojap protein YP_459536.1 COG1576 Uncharacterized conserved protein YP_459537.1 COG4942 Membrane-bound metallopeptidase YP_459538.1 COG0793 Periplasmic protease YP_459539.1 COG1495 Disulfide bond formation protein DsbB YP_459540.1 COG2941 Ubiquinone biosynthesis protein COQ7 YP_459542.1 COG0381 UDP-N-acetylglucosamine 2-epimerase YP_459543.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_459544.1 COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase YP_459545.1 COG0673 Predicted dehydrogenases and related proteins YP_459546.1 COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_459547.1 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_459548.1 COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase YP_459550.1 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_459551.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_459552.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_459553.1 COG0438 Glycosyltransferase YP_459554.1 COG0110 acetyltransferase (isoleucine patch superfamily) YP_459555.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_459556.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamide and glutamine to imidazole-glycerolphosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_459557.1 COG0118 Glutamine amidotransferase YP_459558.1 COG0673 Predicted dehydrogenases and related proteins YP_459559.1 COG0110 acetyltransferase (isoleucine patch superfamily) YP_459560.1 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_459561.1 COG0438 Glycosyltransferase YP_459562.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis YP_459563.1 COG1086 Predicted nucleoside-diphosphate sugar epimerases YP_459565.1 COG1062 Zn-dependent alcohol dehydrogenases, class III YP_459566.1 COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis YP_459567.1 COG1596 Periplasmic protein involved in polysaccharide export YP_459568.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_459570.1 COG0623 Enoyl-ACP reductase (NADH) YP_459571.1 COG1295 Predicted membrane protein YP_459572.1 COG2214 DnaJ-class molecular chaperone YP_459573.1 COG1089 GDP-D-mannose dehydratase YP_459574.1 COG1482 Phosphomannose isomerase YP_459575.1 COG0836 Mannose-1-phosphate guanylyltransferase YP_459576.1 COG0259 Pyridoxamine-phosphate oxidase YP_459577.1 COG0053 Predicted Co/Zn/Cd cation transporters YP_459578.1 COG0384 Predicted epimerase, PhzC/PhzF homolog YP_459579.1 COG1680 Beta-lactamase class C and other penicillin binding proteins YP_459581.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_459582.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_459585.1 COG2261 Predicted membrane protein YP_459586.1 COG0845 Membrane-fusion protein YP_459587.1 COG0841 Cation/multidrug efflux pump YP_459588.1 COG2733 Predicted membrane protein YP_459589.1 COG2025 Electron transfer flavoprotein, alpha subunit YP_459590.1 COG2086 Electron transfer flavoprotein, beta subunit YP_459593.1 catalyzes the interconversion of succinyl-CoA and succinate YP_459594.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_459595.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_459596.1 COG1253 Hemolysins and related proteins containing CBS domains YP_459598.1 COG0597 Lipoprotein signal peptidase YP_459599.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_459601.1 COG0196 FAD synthase YP_459602.1 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog YP_459603.1 COG0262 Dihydrofolate reductase YP_459604.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_459605.1 phosphoribosylaminoimidazole carboxylase, catalytic subunit; COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_459606.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_459607.1 COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) YP_459608.1 COG3402 Uncharacterized conserved protein YP_459609.1 COG3428 Predicted membrane protein YP_459610.1 COG2388 Predicted acetyltransferase YP_459611.1 COG2008 Threonine aldolase YP_459612.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_459613.1 COG0451 Nucleoside-diphosphate-sugar epimerases YP_459614.1 COG0308 Aminopeptidase N YP_459615.1 COG1496 Uncharacterized conserved protein YP_459616.1 COG0723 Rieske Fe-S protein YP_459617.1 ubiquinol-cytochrome c reductase, cytochrome b; COG1290 Cytochrome b subunit of the bc complex YP_459618.1 COG2857 Cytochrome c1 YP_459619.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_459620.1 COG0025 NhaP-type Na+/H+ and K+/H+ antiporters YP_459621.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_459622.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase YP_459623.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_459624.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_459626.1 COG0501 Zn-dependent protease with chaperone function YP_459629.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_459630.1 COG1192 ATPases involved in chromosome partitioning YP_459631.1 COG2214 DnaJ-class molecular chaperone YP_459632.1 COG1109 Phosphomannomutase YP_459634.1 COG1201 Lhr-like helicases YP_459635.1 COG0848 Biopolymer transport protein YP_459636.1 COG0848 Biopolymer transport protein YP_459637.1 COG0848 Biopolymer transport protein YP_459638.1 COG0848 Biopolymer transport protein YP_459639.1 COG0811 Biopolymer transport proteins YP_459640.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_459643.1 COG0824 Predicted thioesterase YP_459644.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_459646.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_459647.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_459648.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_459650.1 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_459651.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459652.2 COG0291 Ribosomal protein L35 YP_459653.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_459654.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_459656.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_459657.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_459658.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_459659.1 COG4108 Peptide chain release factor RF-3 YP_459661.1 COG3568 Metal-dependent hydrolase YP_459662.1 COG0347 Nitrogen regulatory protein PII YP_459663.1 COG0004 Ammonia permease YP_459664.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459665.1 COG2303 Choline dehydrogenase and related flavoproteins YP_459666.1 COG3000 Sterol desaturase YP_459667.1 COG0188 Type IIA topoisomerase(DNA gyrase/topo II, topoisomeraseIV), A subunit YP_459668.1 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase YP_459669.1 COG3453 Uncharacterized protein conserved in bacteria YP_459670.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_459671.1 COG1278 Cold shock proteins YP_459672.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_459673.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_459674.1 COG1281 Disulfide bond chaperones of the HSP33 family YP_459676.1 COG0603 Predicted PP-loop superfamily ATPase YP_459677.1 COG0477 Permeases of the major facilitator superfamily YP_459678.1 COG2032 Cu/Zn superoxide dismutase YP_459679.1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_459680.1 COG2046 ATP sulfurylase (sulfate adenylyltransferase) YP_459682.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) YP_459683.1 similar to Rhodobacter capsulatus gene transfer agent (GTA)orfg13 (37 121dentity); COG5449 Uncharacterized conserved protein YP_459684.1 COG5448 Uncharacterized conserved protein YP_459685.1 COG5281 Phage-related minor tail protein YP_459692.1 COG4653 Predicted phage phi-C31 gp36 major capsid-like protein YP_459693.1 similar to Rodabacter capsulatus GTA orfg4; COG3740 Phage head maturation protease YP_459695.1 COG4695 Phage-related protein YP_459696.1 COG2827 Predicted endonuclease containing a URI domain YP_459697.1 COG5323 Uncharacterized conserved protein YP_459699.1 COG1238 Predicted membrane protein YP_459700.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_459701.1 COG3000 Sterol desaturase YP_459702.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_459703.1 COG1764 Predicted redox protein, regulator of disulfide bond formation YP_459704.1 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes YP_459705.1 COG0236 ACP YP_459706.1 COG0784 FOG: CheY-like receiver YP_459709.1 COG0251 translation initiation inhibitor, yjgF family YP_459710.1 COG0584 Glycerophosphoryl diester phosphodiesterase YP_459711.1 COG3146 Uncharacterized protein conserved in bacteria YP_459712.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_459713.1 COG1734 DnaK suppressor protein YP_459715.1 COG4166 ABC-type oligopeptide transport system, periplasmic component YP_459717.1 COG3483 Tryptophan 2,3-dioxygenase (vermilion) YP_459718.1 COG1878 Predicted metal-dependent hydrolase YP_459719.1 COG3844 Kynureninase YP_459721.1 COG1403 Restriction endonuclease YP_459722.1 COG0008 Glutamyl- and glutaminyl-tRNA synthetases YP_459724.1 COG2096 Uncharacterized conserved protein YP_459725.1 COG1250 3-hydroxyacyl-CoA dehydrogenase YP_459727.1 COG2149 Predicted membrane protein YP_459729.1 This protein performs the mismatch recognition step during the DNA repair process YP_459730.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_459731.1 COG0520 Selenocysteine lyase YP_459732.1 COG3685 Uncharacterized protein conserved in bacteria YP_459733.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_459734.1 COG0793 Periplasmic protease YP_459735.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_459736.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_459737.1 COG1137 ABC-type (unclassified) transport system, ATPase component YP_459739.1 COG2823 Predicted periplasmic or secreted lipoprotein YP_459740.1 COG0221 Inorganic pyrophosphatase YP_459741.1 COG0124 Histidyl-tRNA synthetase YP_459742.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_459743.1 COG2890 Methylase of polypeptide chain release factors YP_459745.1 COG0815 Apolipoprotein N-acyltransferase YP_459746.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_459747.1 COG2311 Predicted membrane protein YP_459748.1 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase YP_459749.1 COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_459750.1 COG2503 Predicted secreted acid phosphatase YP_459751.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_459753.1 COG0464 ATPases of the AAA+ class YP_459754.1 COG0668 Small-conductance mechanosensitive channel YP_459755.1 COG0258 5'-3' exonuclease (including N-terminal domain of PolI) YP_459757.1 COG2367 Beta-lactamase class A YP_459758.1 COG5622 Protein required for attachment to host cells YP_459759.1 COG3173 Predicted aminoglycoside phosphotransferase YP_459760.1 COG1960 Acyl-CoA dehydrogenases YP_459761.1 COG3544 Uncharacterized protein conserved in bacteria YP_459762.1 COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases YP_459763.1 COG4805 Uncharacterized protein conserved in bacteria YP_459764.1 COG3667 Uncharacterized protein involved in copper resistance YP_459765.1 COG2132 multicopper oxidases YP_459766.1 COG1937 Uncharacterized protein conserved in bacteria YP_459767.1 COG3544 Uncharacterized protein conserved in bacteria YP_459769.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_459770.1 COG0234 Co-chaperonin GroES (HSP10) YP_459771.1 COG0668 Small-conductance mechanosensitive channel YP_459772.1 COG0534 Na+-driven multidrug efflux pump YP_459773.1 COG0222 Ribosomal protein L7/L12 YP_459774.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_459776.1 COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 YP_459777.1 COG3655 Predicted transcriptional regulator YP_459778.1 COG0477 Permeases of the major facilitator superfamily YP_459780.1 COG1835 Predicted acyltransferases YP_459781.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_459783.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_459785.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_459786.1 COG0469 Pyruvate kinase YP_459787.1 COG3492 Uncharacterized protein conserved in bacteria YP_459788.1 COG3750 Uncharacterized protein conserved in bacteria YP_459789.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459790.1 COG0393 Uncharacterized conserved protein YP_459792.1 COG0217 Uncharacterized conserved protein YP_459793.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_459794.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_459795.1 COG0584 Glycerophosphoryl diester phosphodiesterase YP_459796.1 Involved in ubiquinone biosynthesis YP_459797.1 COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin YP_459798.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_459799.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_459800.1 COG5266 ABC-type Co2+ transport system, periplasmic component YP_459801.1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_459802.1 COG0412 Dienelactone hydrolase and related enzymes YP_459803.1 COG4993 Glucose dehydrogenase YP_459804.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_459805.1 COG1585 Membrane protein implicated in regulation of membrane protease activity YP_459806.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_459807.1 COG0582 Integrase YP_459811.1 COG1525 Micrococcal nuclease (thermonuclease) homologs YP_459812.1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_459815.1 COG1475 Predicted transcriptional regulators YP_459818.1 COG4227 Antirestriction protein YP_459823.1 COG0629 Single-stranded DNA-binding protein YP_459826.1 COG2352 Phosphoenolpyruvate carboxylase YP_459827.1 COG3505 Type IV secretory pathway, VirD4 components YP_459829.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_459830.1 COG2932 Predicted transcriptional regulator YP_459835.1 COG1196 Chromosome segregation ATPases YP_459836.1 COG1195 Recombinational DNA repair ATPase (RecF pathway) YP_459838.1 COG1002 Type II restriction enzyme, methylase subunits YP_459840.1 COG4930 Predicted ATP-dependent Lon-type protease YP_459841.1 COG1637 Predicted nuclease of the RecB family YP_459842.1 COG3550 Uncharacterized protein related to capsule biosynthesis enzymes YP_459846.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_459847.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell YP_459851.1 COG0681 Signal peptidase I YP_459854.1 COG3451 Type IV secretory pathway, VirB4 components YP_459856.1 COG1651 Protein-disulfide isomerase YP_459863.1 COG3311 Predicted transcriptional regulator YP_459868.1 COG2801 Transposase and inactivated derivatives YP_459869.1 COG2801 Transposase and inactivated derivatives YP_459870.1 COG0661 Predicted unusual protein kinase YP_459871.1 COG1846 Transcriptional regulators YP_459872.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_459873.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_459874.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459875.1 COG1960 Acyl-CoA dehydrogenases YP_459876.1 COG1960 Acyl-CoA dehydrogenases YP_459877.1 COG0633 Ferredoxin YP_459878.1 COG2124 Cytochrome P450 YP_459879.1 COG2186 Transcriptional regulators YP_459880.1 COG2070 Dioxygenases related to 2-nitropropane dioxygenase YP_459881.1 COG5031 Uncharacterized protein involved in ubiquinone biosynthesis YP_459882.1 COG0183 Acetyl-CoA acetyltransferase YP_459883.1 COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon YP_459884.1 COG1960 Acyl-CoA dehydrogenases YP_459885.1 COG1960 Acyl-CoA dehydrogenases YP_459886.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_459887.1 COG2072 Predicted flavoprotein involved in K+ transport YP_459888.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_459889.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_459890.1 COG1538 Outer membrane protein YP_459891.1 COG0477 Permeases of the major facilitator superfamily YP_459892.1 COG1566 Multidrug resistance efflux pump YP_459894.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_459896.1 COG0515 Serine/threonine protein kinase YP_459897.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_459898.1 COG3210 Large exoprotein involved in heme utilization or adhesion YP_459899.1 COG2931 RTX toxins and related Ca2+-binding proteins