-- dump date 20140619_080531 -- class Genbank::misc_feature -- table misc_feature_note -- id note 630626000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 630626000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 630626000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626000004 Walker A motif; other site 630626000005 ATP binding site [chemical binding]; other site 630626000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 630626000007 Walker B motif; other site 630626000008 arginine finger; other site 630626000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 630626000010 DnaA box-binding interface [nucleotide binding]; other site 630626000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 630626000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 630626000013 putative DNA binding surface [nucleotide binding]; other site 630626000014 dimer interface [polypeptide binding]; other site 630626000015 beta-clamp/clamp loader binding surface; other site 630626000016 beta-clamp/translesion DNA polymerase binding surface; other site 630626000017 recF protein; Region: recf; TIGR00611 630626000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626000019 Walker A/P-loop; other site 630626000020 ATP binding site [chemical binding]; other site 630626000021 Q-loop/lid; other site 630626000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626000023 ABC transporter signature motif; other site 630626000024 Walker B; other site 630626000025 D-loop; other site 630626000026 H-loop/switch region; other site 630626000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 630626000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626000029 Mg2+ binding site [ion binding]; other site 630626000030 G-X-G motif; other site 630626000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 630626000032 anchoring element; other site 630626000033 dimer interface [polypeptide binding]; other site 630626000034 ATP binding site [chemical binding]; other site 630626000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 630626000036 active site 630626000037 putative metal-binding site [ion binding]; other site 630626000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 630626000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 630626000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626000041 active site 630626000042 motif I; other site 630626000043 motif II; other site 630626000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626000045 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 630626000046 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 630626000047 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 630626000048 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 630626000049 active site 630626000050 intersubunit interface [polypeptide binding]; other site 630626000051 catalytic residue [active] 630626000052 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 630626000053 hypothetical protein; Provisional; Region: PRK11616 630626000054 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 630626000055 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 630626000056 putative dimer interface [polypeptide binding]; other site 630626000057 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 630626000058 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 630626000059 putative dimer interface [polypeptide binding]; other site 630626000060 putative transporter; Validated; Region: PRK03818 630626000061 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 630626000062 TrkA-C domain; Region: TrkA_C; pfam02080 630626000063 TrkA-C domain; Region: TrkA_C; pfam02080 630626000064 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 630626000065 Predicted membrane protein [Function unknown]; Region: COG2149 630626000066 Domain of unknown function (DUF202); Region: DUF202; cl09954 630626000067 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 630626000068 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 630626000069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000070 putative substrate translocation pore; other site 630626000071 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 630626000072 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 630626000073 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 630626000074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626000075 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 630626000076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626000077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626000078 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 630626000079 putative effector binding pocket; other site 630626000080 putative dimerization interface [polypeptide binding]; other site 630626000081 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 630626000082 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626000083 N-terminal plug; other site 630626000084 ligand-binding site [chemical binding]; other site 630626000085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626000086 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 630626000087 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 630626000088 FMN binding site [chemical binding]; other site 630626000089 active site 630626000090 substrate binding site [chemical binding]; other site 630626000091 catalytic residue [active] 630626000092 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 630626000093 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626000094 N-terminal plug; other site 630626000095 ligand-binding site [chemical binding]; other site 630626000096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626000097 Helix-turn-helix domain; Region: HTH_28; pfam13518 630626000098 Helix-turn-helix domain; Region: HTH_28; pfam13518 630626000099 putative transposase OrfB; Reviewed; Region: PHA02517 630626000100 HTH-like domain; Region: HTH_21; pfam13276 630626000101 Integrase core domain; Region: rve; pfam00665 630626000102 Integrase core domain; Region: rve_2; pfam13333 630626000103 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 630626000104 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 630626000105 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626000106 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 630626000107 Outer membrane efflux protein; Region: OEP; pfam02321 630626000108 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 630626000109 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 630626000110 sensor kinase CusS; Provisional; Region: PRK09835 630626000111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626000112 dimerization interface [polypeptide binding]; other site 630626000113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626000114 dimer interface [polypeptide binding]; other site 630626000115 phosphorylation site [posttranslational modification] 630626000116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626000117 ATP binding site [chemical binding]; other site 630626000118 Mg2+ binding site [ion binding]; other site 630626000119 G-X-G motif; other site 630626000120 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 630626000121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626000122 active site 630626000123 phosphorylation site [posttranslational modification] 630626000124 intermolecular recognition site; other site 630626000125 dimerization interface [polypeptide binding]; other site 630626000126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626000127 DNA binding site [nucleotide binding] 630626000128 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 630626000129 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 630626000130 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 630626000131 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 630626000132 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 630626000133 PapC N-terminal domain; Region: PapC_N; pfam13954 630626000134 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 630626000135 PapC C-terminal domain; Region: PapC_C; pfam13953 630626000136 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 630626000137 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626000138 PilZ domain; Region: PilZ; pfam07238 630626000139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626000140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626000141 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 630626000142 active site residue [active] 630626000143 putrescine transporter; Provisional; Region: potE; PRK10655 630626000144 arginine decarboxylase; Provisional; Region: PRK15029 630626000145 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 630626000146 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 630626000147 homodimer interface [polypeptide binding]; other site 630626000148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626000149 catalytic residue [active] 630626000150 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 630626000151 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 630626000152 arginine repressor; Provisional; Region: PRK05066 630626000153 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 630626000154 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 630626000155 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 630626000156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626000157 non-specific DNA binding site [nucleotide binding]; other site 630626000158 salt bridge; other site 630626000159 sequence-specific DNA binding site [nucleotide binding]; other site 630626000160 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 630626000161 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626000162 putative effector binding pocket; other site 630626000163 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 630626000164 Sulfatase; Region: Sulfatase; pfam00884 630626000165 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 630626000166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626000167 FeS/SAM binding site; other site 630626000168 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 630626000169 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 630626000170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 630626000171 SCP-2 sterol transfer family; Region: SCP2; pfam02036 630626000172 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 630626000173 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 630626000174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626000175 catalytic residue [active] 630626000176 Virulence protein [General function prediction only]; Region: COG3943 630626000177 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 630626000178 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 630626000179 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 630626000180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626000181 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 630626000182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 630626000183 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 630626000184 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 630626000185 iron binding site [ion binding]; other site 630626000186 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 630626000187 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 630626000188 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 630626000189 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 630626000190 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 630626000191 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 630626000192 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626000193 molybdopterin cofactor binding site; other site 630626000194 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 630626000195 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 630626000196 molybdopterin cofactor binding site; other site 630626000197 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626000198 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 630626000199 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 630626000200 AzlC protein; Region: AzlC; cl00570 630626000201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 630626000202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626000203 non-specific DNA binding site [nucleotide binding]; other site 630626000204 salt bridge; other site 630626000205 sequence-specific DNA binding site [nucleotide binding]; other site 630626000206 Cupin domain; Region: Cupin_2; cl17218 630626000207 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 630626000208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626000209 non-specific DNA binding site [nucleotide binding]; other site 630626000210 salt bridge; other site 630626000211 sequence-specific DNA binding site [nucleotide binding]; other site 630626000212 Domain of unknown function (DUF718); Region: DUF718; cl01281 630626000213 lactaldehyde reductase; Region: lactal_redase; TIGR02638 630626000214 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 630626000215 dimer interface [polypeptide binding]; other site 630626000216 active site 630626000217 metal binding site [ion binding]; metal-binding site 630626000218 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 630626000219 intersubunit interface [polypeptide binding]; other site 630626000220 active site 630626000221 Zn2+ binding site [ion binding]; other site 630626000222 L-rhamnose isomerase; Provisional; Region: PRK01076 630626000223 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 630626000224 N- and C-terminal domain interface [polypeptide binding]; other site 630626000225 active site 630626000226 putative catalytic site [active] 630626000227 metal binding site [ion binding]; metal-binding site 630626000228 ATP binding site [chemical binding]; other site 630626000229 rhamnulokinase; Provisional; Region: rhaB; PRK10640 630626000230 carbohydrate binding site [chemical binding]; other site 630626000231 transcriptional activator RhaS; Provisional; Region: PRK13503 630626000232 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 630626000233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626000234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626000235 transcriptional activator RhaR; Provisional; Region: PRK13502 630626000236 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 630626000237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626000238 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 630626000239 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 630626000240 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 630626000241 superoxide dismutase; Provisional; Region: PRK10925 630626000242 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 630626000243 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 630626000244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 630626000245 DNA binding residues [nucleotide binding] 630626000246 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 630626000247 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 630626000248 Autotransporter beta-domain; Region: Autotransporter; pfam03797 630626000249 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 630626000250 MOSC domain; Region: MOSC; pfam03473 630626000251 3-alpha domain; Region: 3-alpha; pfam03475 630626000252 hypothetical protein; Provisional; Region: PRK11020 630626000253 putative glutathione S-transferase; Provisional; Region: PRK10357 630626000254 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 630626000255 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 630626000256 dimer interface [polypeptide binding]; other site 630626000257 N-terminal domain interface [polypeptide binding]; other site 630626000258 putative substrate binding pocket (H-site) [chemical binding]; other site 630626000259 selenocysteine synthase; Provisional; Region: PRK04311 630626000260 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 630626000261 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 630626000262 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 630626000263 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 630626000264 G1 box; other site 630626000265 putative GEF interaction site [polypeptide binding]; other site 630626000266 GTP/Mg2+ binding site [chemical binding]; other site 630626000267 Switch I region; other site 630626000268 G2 box; other site 630626000269 G3 box; other site 630626000270 Switch II region; other site 630626000271 G4 box; other site 630626000272 G5 box; other site 630626000273 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 630626000274 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 630626000275 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 630626000276 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 630626000277 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 630626000278 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 630626000279 NAD(P) binding site [chemical binding]; other site 630626000280 catalytic residues [active] 630626000281 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 630626000282 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 630626000283 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 630626000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626000285 Walker A motif; other site 630626000286 ATP binding site [chemical binding]; other site 630626000287 Walker B motif; other site 630626000288 arginine finger; other site 630626000289 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 630626000290 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 630626000291 dimerization interface [polypeptide binding]; other site 630626000292 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 630626000293 ATP binding site [chemical binding]; other site 630626000294 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 630626000295 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 630626000296 hydrogenase assembly chaperone; Provisional; Region: PRK10409 630626000297 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 630626000298 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 630626000299 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 630626000300 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 630626000301 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 630626000302 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 630626000303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626000304 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 630626000305 NADH dehydrogenase; Region: NADHdh; cl00469 630626000306 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 630626000307 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 630626000308 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 630626000309 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 630626000310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626000311 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 630626000312 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 630626000313 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 630626000314 nickel binding site [ion binding]; other site 630626000315 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 630626000316 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 630626000317 Acylphosphatase; Region: Acylphosphatase; pfam00708 630626000318 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 630626000319 HypF finger; Region: zf-HYPF; pfam07503 630626000320 HypF finger; Region: zf-HYPF; pfam07503 630626000321 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 630626000322 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 630626000323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626000324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626000325 homodimer interface [polypeptide binding]; other site 630626000326 catalytic residue [active] 630626000327 hypothetical protein; Provisional; Region: PRK10356 630626000328 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 630626000329 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 630626000330 putative dimerization interface [polypeptide binding]; other site 630626000331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626000332 putative ligand binding site [chemical binding]; other site 630626000333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626000334 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 630626000335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626000336 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 630626000337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000338 xylose isomerase; Provisional; Region: PRK05474 630626000339 xylose isomerase; Region: xylose_isom_A; TIGR02630 630626000340 xylulokinase; Provisional; Region: PRK15027 630626000341 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 630626000342 N- and C-terminal domain interface [polypeptide binding]; other site 630626000343 active site 630626000344 MgATP binding site [chemical binding]; other site 630626000345 catalytic site [active] 630626000346 metal binding site [ion binding]; metal-binding site 630626000347 xylulose binding site [chemical binding]; other site 630626000348 homodimer interface [polypeptide binding]; other site 630626000349 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 630626000350 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 630626000351 Acyltransferase family; Region: Acyl_transf_3; pfam01757 630626000352 YsaB-like lipoprotein; Region: YsaB; pfam13983 630626000353 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 630626000354 dimer interface [polypeptide binding]; other site 630626000355 motif 1; other site 630626000356 active site 630626000357 motif 2; other site 630626000358 motif 3; other site 630626000359 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 630626000360 DALR anticodon binding domain; Region: DALR_1; pfam05746 630626000361 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 630626000362 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 630626000363 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 630626000364 dimerization interface [polypeptide binding]; other site 630626000365 ligand binding site [chemical binding]; other site 630626000366 NADP binding site [chemical binding]; other site 630626000367 catalytic site [active] 630626000368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000369 D-galactonate transporter; Region: 2A0114; TIGR00893 630626000370 putative substrate translocation pore; other site 630626000371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 630626000372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 630626000373 substrate binding site [chemical binding]; other site 630626000374 ATP binding site [chemical binding]; other site 630626000375 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 630626000376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626000377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626000378 DNA binding site [nucleotide binding] 630626000379 domain linker motif; other site 630626000380 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 630626000381 putative dimerization interface [polypeptide binding]; other site 630626000382 putative ligand binding site [chemical binding]; other site 630626000383 putative outer membrane lipoprotein; Provisional; Region: PRK10510 630626000384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 630626000385 ligand binding site [chemical binding]; other site 630626000386 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 630626000387 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 630626000388 molybdopterin cofactor binding site [chemical binding]; other site 630626000389 substrate binding site [chemical binding]; other site 630626000390 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 630626000391 molybdopterin cofactor binding site; other site 630626000392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 630626000393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626000394 Coenzyme A binding pocket [chemical binding]; other site 630626000395 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 630626000396 Autotransporter beta-domain; Region: Autotransporter; cl17461 630626000397 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 630626000398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000399 putative substrate translocation pore; other site 630626000400 phosphoethanolamine transferase; Provisional; Region: PRK11560 630626000401 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 630626000402 Sulfatase; Region: Sulfatase; pfam00884 630626000403 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 630626000404 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 630626000405 peptide binding site [polypeptide binding]; other site 630626000406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 630626000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626000408 dimer interface [polypeptide binding]; other site 630626000409 conserved gate region; other site 630626000410 putative PBP binding loops; other site 630626000411 ABC-ATPase subunit interface; other site 630626000412 dipeptide transporter; Provisional; Region: PRK10913 630626000413 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 630626000414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626000415 dimer interface [polypeptide binding]; other site 630626000416 conserved gate region; other site 630626000417 putative PBP binding loops; other site 630626000418 ABC-ATPase subunit interface; other site 630626000419 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 630626000420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626000421 Walker A/P-loop; other site 630626000422 ATP binding site [chemical binding]; other site 630626000423 Q-loop/lid; other site 630626000424 ABC transporter signature motif; other site 630626000425 Walker B; other site 630626000426 D-loop; other site 630626000427 H-loop/switch region; other site 630626000428 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 630626000429 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 630626000430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626000431 Walker A/P-loop; other site 630626000432 ATP binding site [chemical binding]; other site 630626000433 Q-loop/lid; other site 630626000434 ABC transporter signature motif; other site 630626000435 Walker B; other site 630626000436 D-loop; other site 630626000437 H-loop/switch region; other site 630626000438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 630626000439 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 630626000440 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 630626000441 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 630626000442 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 630626000443 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 630626000444 YhjQ protein; Region: YhjQ; pfam06564 630626000445 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 630626000446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626000447 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 630626000448 DXD motif; other site 630626000449 PilZ domain; Region: PilZ; pfam07238 630626000450 cellulose synthase regulator protein; Provisional; Region: PRK11114 630626000451 endo-1,4-D-glucanase; Provisional; Region: PRK11097 630626000452 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 630626000453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626000454 binding surface 630626000455 TPR motif; other site 630626000456 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 630626000457 putative diguanylate cyclase; Provisional; Region: PRK13561 630626000458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626000459 I-site; other site 630626000460 active site 630626000461 metal binding site [ion binding]; metal-binding site 630626000462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626000463 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 630626000464 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 630626000465 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 630626000466 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 630626000467 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 630626000468 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 630626000469 substrate binding site [chemical binding]; other site 630626000470 ATP binding site [chemical binding]; other site 630626000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000472 metabolite-proton symporter; Region: 2A0106; TIGR00883 630626000473 putative substrate translocation pore; other site 630626000474 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 630626000475 trehalase; Provisional; Region: treF; PRK13270 630626000476 Trehalase; Region: Trehalase; pfam01204 630626000477 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 630626000478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000479 putative substrate translocation pore; other site 630626000480 TetR family transcriptional regulator; Provisional; Region: PRK14996 630626000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626000482 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 630626000483 penicillin-binding protein 2; Provisional; Region: PRK10795 630626000484 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 630626000485 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 630626000486 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 630626000487 inner membrane protein; Provisional; Region: PRK10995 630626000488 glutathione reductase; Validated; Region: PRK06116 630626000489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 630626000490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626000491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 630626000492 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 630626000493 oligopeptidase A; Provisional; Region: PRK10911 630626000494 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 630626000495 active site 630626000496 Zn binding site [ion binding]; other site 630626000497 putative methyltransferase; Provisional; Region: PRK10742 630626000498 Predicted transcriptional regulator [Transcription]; Region: COG1959 630626000499 Transcriptional regulator; Region: Rrf2; pfam02082 630626000500 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 630626000501 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626000502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626000503 Ligand Binding Site [chemical binding]; other site 630626000504 universal stress protein UspB; Provisional; Region: PRK04960 630626000505 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 630626000506 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 630626000507 Predicted flavoproteins [General function prediction only]; Region: COG2081 630626000508 hypothetical protein; Provisional; Region: PRK11615 630626000509 hypothetical protein; Provisional; Region: PRK11212 630626000510 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 630626000511 CPxP motif; other site 630626000512 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 630626000513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 630626000514 metal-binding site [ion binding] 630626000515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 630626000516 Soluble P-type ATPase [General function prediction only]; Region: COG4087 630626000517 Predicted membrane protein [Function unknown]; Region: COG3714 630626000518 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 630626000519 hypothetical protein; Provisional; Region: PRK10910 630626000520 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 630626000521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626000522 S-adenosylmethionine binding site [chemical binding]; other site 630626000523 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 630626000524 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 630626000525 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 630626000526 P loop; other site 630626000527 GTP binding site [chemical binding]; other site 630626000528 cell division protein FtsE; Provisional; Region: PRK10908 630626000529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626000530 Walker A/P-loop; other site 630626000531 ATP binding site [chemical binding]; other site 630626000532 Q-loop/lid; other site 630626000533 ABC transporter signature motif; other site 630626000534 Walker B; other site 630626000535 D-loop; other site 630626000536 H-loop/switch region; other site 630626000537 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 630626000538 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 630626000539 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 630626000540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 630626000541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 630626000542 DNA binding residues [nucleotide binding] 630626000543 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 630626000544 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 630626000545 dimerization interface [polypeptide binding]; other site 630626000546 ligand binding site [chemical binding]; other site 630626000547 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 630626000548 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 630626000549 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 630626000550 dimerization interface [polypeptide binding]; other site 630626000551 ligand binding site [chemical binding]; other site 630626000552 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626000553 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 630626000554 TM-ABC transporter signature motif; other site 630626000555 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 630626000556 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 630626000557 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 630626000558 TM-ABC transporter signature motif; other site 630626000559 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 630626000560 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 630626000561 Walker A/P-loop; other site 630626000562 ATP binding site [chemical binding]; other site 630626000563 Q-loop/lid; other site 630626000564 ABC transporter signature motif; other site 630626000565 Walker B; other site 630626000566 D-loop; other site 630626000567 H-loop/switch region; other site 630626000568 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 630626000569 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 630626000570 Walker A/P-loop; other site 630626000571 ATP binding site [chemical binding]; other site 630626000572 Q-loop/lid; other site 630626000573 ABC transporter signature motif; other site 630626000574 Walker B; other site 630626000575 D-loop; other site 630626000576 H-loop/switch region; other site 630626000577 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 630626000578 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 630626000579 putative active site [active] 630626000580 catalytic site [active] 630626000581 putative metal binding site [ion binding]; other site 630626000582 Pirin-related protein [General function prediction only]; Region: COG1741 630626000583 Pirin; Region: Pirin; pfam02678 630626000584 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 630626000585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626000586 DNA binding site [nucleotide binding] 630626000587 domain linker motif; other site 630626000588 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 630626000589 putative ligand binding site [chemical binding]; other site 630626000590 putative dimerization interface [polypeptide binding]; other site 630626000591 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 630626000592 ATP-binding site [chemical binding]; other site 630626000593 Gluconate-6-phosphate binding site [chemical binding]; other site 630626000594 low affinity gluconate transporter; Provisional; Region: PRK10472 630626000595 gluconate transporter; Region: gntP; TIGR00791 630626000596 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 630626000597 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 630626000598 glycogen branching enzyme; Provisional; Region: PRK05402 630626000599 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 630626000600 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 630626000601 active site 630626000602 catalytic site [active] 630626000603 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 630626000604 glycogen debranching enzyme; Provisional; Region: PRK03705 630626000605 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 630626000606 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 630626000607 active site 630626000608 catalytic site [active] 630626000609 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 630626000610 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 630626000611 ligand binding site; other site 630626000612 oligomer interface; other site 630626000613 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 630626000614 dimer interface [polypeptide binding]; other site 630626000615 N-terminal domain interface [polypeptide binding]; other site 630626000616 sulfate 1 binding site; other site 630626000617 glycogen synthase; Provisional; Region: glgA; PRK00654 630626000618 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 630626000619 ADP-binding pocket [chemical binding]; other site 630626000620 homodimer interface [polypeptide binding]; other site 630626000621 glycogen phosphorylase; Provisional; Region: PRK14986 630626000622 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 630626000623 homodimer interface [polypeptide binding]; other site 630626000624 active site pocket [active] 630626000625 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 630626000626 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 630626000627 active site residue [active] 630626000628 intramembrane serine protease GlpG; Provisional; Region: PRK10907 630626000629 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 630626000630 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 630626000631 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 630626000632 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 630626000633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 630626000634 transcriptional regulator MalT; Provisional; Region: PRK04841 630626000635 AAA ATPase domain; Region: AAA_16; pfam13191 630626000636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626000637 DNA binding residues [nucleotide binding] 630626000638 dimerization interface [polypeptide binding]; other site 630626000639 maltodextrin phosphorylase; Provisional; Region: PRK14985 630626000640 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 630626000641 active site pocket [active] 630626000642 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 630626000643 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 630626000644 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 630626000645 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 630626000646 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 630626000647 DNA utilization protein GntX; Provisional; Region: PRK11595 630626000648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626000649 active site 630626000650 carboxylesterase BioH; Provisional; Region: PRK10349 630626000651 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 630626000652 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 630626000653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626000654 putative Zn2+ binding site [ion binding]; other site 630626000655 putative DNA binding site [nucleotide binding]; other site 630626000656 HipA-like N-terminal domain; Region: HipA_N; pfam07805 630626000657 HipA-like C-terminal domain; Region: HipA_C; pfam07804 630626000658 FeoC like transcriptional regulator; Region: FeoC; cl17677 630626000659 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 630626000660 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 630626000661 G1 box; other site 630626000662 GTP/Mg2+ binding site [chemical binding]; other site 630626000663 Switch I region; other site 630626000664 G2 box; other site 630626000665 G3 box; other site 630626000666 Switch II region; other site 630626000667 G4 box; other site 630626000668 G5 box; other site 630626000669 Nucleoside recognition; Region: Gate; pfam07670 630626000670 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 630626000671 Nucleoside recognition; Region: Gate; pfam07670 630626000672 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 630626000673 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 630626000674 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 630626000675 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 630626000676 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 630626000677 RNA binding site [nucleotide binding]; other site 630626000678 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 630626000679 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 630626000680 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 630626000681 osmolarity response regulator; Provisional; Region: ompR; PRK09468 630626000682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626000683 active site 630626000684 phosphorylation site [posttranslational modification] 630626000685 intermolecular recognition site; other site 630626000686 dimerization interface [polypeptide binding]; other site 630626000687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626000688 DNA binding site [nucleotide binding] 630626000689 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 630626000690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626000691 dimerization interface [polypeptide binding]; other site 630626000692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626000693 dimer interface [polypeptide binding]; other site 630626000694 phosphorylation site [posttranslational modification] 630626000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626000696 ATP binding site [chemical binding]; other site 630626000697 G-X-G motif; other site 630626000698 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 630626000699 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 630626000700 active site 630626000701 substrate-binding site [chemical binding]; other site 630626000702 metal-binding site [ion binding] 630626000703 ATP binding site [chemical binding]; other site 630626000704 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 630626000705 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 630626000706 dimerization interface [polypeptide binding]; other site 630626000707 domain crossover interface; other site 630626000708 redox-dependent activation switch; other site 630626000709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626000710 RNA binding surface [nucleotide binding]; other site 630626000711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 630626000712 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 630626000713 motif II; other site 630626000714 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 630626000715 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 630626000716 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 630626000717 ADP-ribose binding site [chemical binding]; other site 630626000718 dimer interface [polypeptide binding]; other site 630626000719 active site 630626000720 nudix motif; other site 630626000721 metal binding site [ion binding]; metal-binding site 630626000722 CblD like pilus biogenesis initiator; Region: CblD; cl06460 630626000723 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 630626000724 Transglycosylase; Region: Transgly; pfam00912 630626000725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 630626000726 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 630626000727 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 630626000728 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 630626000729 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 630626000730 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 630626000731 shikimate kinase; Reviewed; Region: aroK; PRK00131 630626000732 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 630626000733 ADP binding site [chemical binding]; other site 630626000734 magnesium binding site [ion binding]; other site 630626000735 putative shikimate binding site; other site 630626000736 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 630626000737 active site 630626000738 dimer interface [polypeptide binding]; other site 630626000739 metal binding site [ion binding]; metal-binding site 630626000740 cell division protein DamX; Validated; Region: PRK10905 630626000741 cell division protein DamX; Validated; Region: PRK10905 630626000742 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 630626000743 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 630626000744 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 630626000745 substrate binding site [chemical binding]; other site 630626000746 hexamer interface [polypeptide binding]; other site 630626000747 metal binding site [ion binding]; metal-binding site 630626000748 phosphoglycolate phosphatase; Provisional; Region: PRK13222 630626000749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626000750 motif II; other site 630626000751 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 630626000752 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 630626000753 active site 630626000754 HIGH motif; other site 630626000755 dimer interface [polypeptide binding]; other site 630626000756 KMSKS motif; other site 630626000757 siroheme synthase; Provisional; Region: cysG; PRK10637 630626000758 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 630626000759 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 630626000760 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 630626000761 active site 630626000762 SAM binding site [chemical binding]; other site 630626000763 homodimer interface [polypeptide binding]; other site 630626000764 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 630626000765 nitrite reductase subunit NirD; Provisional; Region: PRK14989 630626000766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626000767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 630626000768 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 630626000769 cytosine deaminase; Provisional; Region: PRK09230 630626000770 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 630626000771 active site 630626000772 putative transporter; Provisional; Region: PRK03699 630626000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626000774 putative substrate translocation pore; other site 630626000775 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 630626000776 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 630626000777 substrate binding site [chemical binding]; other site 630626000778 Protein of unknown function (DUF2559); Region: DUF2559; cl08097 630626000779 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 630626000780 cell filamentation protein Fic; Provisional; Region: PRK10347 630626000781 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 630626000782 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 630626000783 glutamine binding [chemical binding]; other site 630626000784 catalytic triad [active] 630626000785 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 630626000786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626000787 inhibitor-cofactor binding pocket; inhibition site 630626000788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626000789 catalytic residue [active] 630626000790 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 630626000791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 630626000792 ligand binding site [chemical binding]; other site 630626000793 flexible hinge region; other site 630626000794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 630626000795 putative switch regulator; other site 630626000796 non-specific DNA interactions [nucleotide binding]; other site 630626000797 DNA binding site [nucleotide binding] 630626000798 sequence specific DNA binding site [nucleotide binding]; other site 630626000799 putative cAMP binding site [chemical binding]; other site 630626000800 hypothetical protein; Provisional; Region: PRK10738 630626000801 phosphoribulokinase; Provisional; Region: PRK15453 630626000802 active site 630626000803 hypothetical protein; Provisional; Region: PRK04966 630626000804 putative hydrolase; Provisional; Region: PRK10985 630626000805 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 630626000806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626000807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626000808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626000809 ABC transporter signature motif; other site 630626000810 Walker B; other site 630626000811 D-loop; other site 630626000812 ABC transporter; Region: ABC_tran_2; pfam12848 630626000813 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626000814 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 630626000815 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 630626000816 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 630626000817 TrkA-N domain; Region: TrkA_N; pfam02254 630626000818 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 630626000819 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 630626000820 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 630626000821 phi X174 lysis protein; Provisional; Region: PRK02793 630626000822 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 630626000823 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 630626000824 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 630626000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 630626000826 YheO-like PAS domain; Region: PAS_6; pfam08348 630626000827 HTH domain; Region: HTH_22; pfam13309 630626000828 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 630626000829 sulfur relay protein TusC; Validated; Region: PRK00211 630626000830 DsrH like protein; Region: DsrH; cl17347 630626000831 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 630626000832 S17 interaction site [polypeptide binding]; other site 630626000833 S8 interaction site; other site 630626000834 16S rRNA interaction site [nucleotide binding]; other site 630626000835 streptomycin interaction site [chemical binding]; other site 630626000836 23S rRNA interaction site [nucleotide binding]; other site 630626000837 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 630626000838 30S ribosomal protein S7; Validated; Region: PRK05302 630626000839 elongation factor G; Reviewed; Region: PRK00007 630626000840 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 630626000841 G1 box; other site 630626000842 putative GEF interaction site [polypeptide binding]; other site 630626000843 GTP/Mg2+ binding site [chemical binding]; other site 630626000844 Switch I region; other site 630626000845 G2 box; other site 630626000846 G3 box; other site 630626000847 Switch II region; other site 630626000848 G4 box; other site 630626000849 G5 box; other site 630626000850 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 630626000851 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 630626000852 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 630626000853 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 630626000854 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 630626000855 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 630626000856 heme binding site [chemical binding]; other site 630626000857 ferroxidase pore; other site 630626000858 ferroxidase diiron center [ion binding]; other site 630626000859 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 630626000860 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 630626000861 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 630626000862 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 630626000863 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 630626000864 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 630626000865 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 630626000866 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 630626000867 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 630626000868 protein-rRNA interface [nucleotide binding]; other site 630626000869 putative translocon binding site; other site 630626000870 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 630626000871 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 630626000872 G-X-X-G motif; other site 630626000873 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 630626000874 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 630626000875 23S rRNA interface [nucleotide binding]; other site 630626000876 5S rRNA interface [nucleotide binding]; other site 630626000877 putative antibiotic binding site [chemical binding]; other site 630626000878 L25 interface [polypeptide binding]; other site 630626000879 L27 interface [polypeptide binding]; other site 630626000880 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 630626000881 23S rRNA interface [nucleotide binding]; other site 630626000882 putative translocon interaction site; other site 630626000883 signal recognition particle (SRP54) interaction site; other site 630626000884 L23 interface [polypeptide binding]; other site 630626000885 trigger factor interaction site; other site 630626000886 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 630626000887 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 630626000888 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 630626000889 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 630626000890 RNA binding site [nucleotide binding]; other site 630626000891 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 630626000892 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 630626000893 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 630626000894 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 630626000895 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 630626000896 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 630626000897 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 630626000898 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 630626000899 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 630626000900 23S rRNA interface [nucleotide binding]; other site 630626000901 5S rRNA interface [nucleotide binding]; other site 630626000902 L27 interface [polypeptide binding]; other site 630626000903 L5 interface [polypeptide binding]; other site 630626000904 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 630626000905 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 630626000906 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 630626000907 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 630626000908 23S rRNA binding site [nucleotide binding]; other site 630626000909 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 630626000910 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 630626000911 SecY translocase; Region: SecY; pfam00344 630626000912 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 630626000913 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 630626000914 30S ribosomal protein S13; Region: bact_S13; TIGR03631 630626000915 30S ribosomal protein S11; Validated; Region: PRK05309 630626000916 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 630626000917 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 630626000918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626000919 RNA binding surface [nucleotide binding]; other site 630626000920 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 630626000921 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 630626000922 alphaNTD homodimer interface [polypeptide binding]; other site 630626000923 alphaNTD - beta interaction site [polypeptide binding]; other site 630626000924 alphaNTD - beta' interaction site [polypeptide binding]; other site 630626000925 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 630626000926 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 630626000927 hypothetical protein; Provisional; Region: PRK10203 630626000928 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 630626000929 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 630626000930 DNA binding residues [nucleotide binding] 630626000931 dimer interface [polypeptide binding]; other site 630626000932 metal binding site [ion binding]; metal-binding site 630626000933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 630626000934 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 630626000935 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 630626000936 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 630626000937 TrkA-N domain; Region: TrkA_N; pfam02254 630626000938 TrkA-C domain; Region: TrkA_C; pfam02080 630626000939 TrkA-N domain; Region: TrkA_N; pfam02254 630626000940 TrkA-C domain; Region: TrkA_C; pfam02080 630626000941 16S rRNA methyltransferase B; Provisional; Region: PRK10901 630626000942 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 630626000943 putative RNA binding site [nucleotide binding]; other site 630626000944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626000945 S-adenosylmethionine binding site [chemical binding]; other site 630626000946 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 630626000947 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 630626000948 putative active site [active] 630626000949 substrate binding site [chemical binding]; other site 630626000950 putative cosubstrate binding site; other site 630626000951 catalytic site [active] 630626000952 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 630626000953 substrate binding site [chemical binding]; other site 630626000954 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 630626000955 active site 630626000956 catalytic residues [active] 630626000957 metal binding site [ion binding]; metal-binding site 630626000958 hypothetical protein; Provisional; Region: PRK10736 630626000959 DNA protecting protein DprA; Region: dprA; TIGR00732 630626000960 hypothetical protein; Validated; Region: PRK03430 630626000961 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 630626000962 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 630626000963 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 630626000964 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 630626000965 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 630626000966 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 630626000967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 630626000968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 630626000969 shikimate binding site; other site 630626000970 NAD(P) binding site [chemical binding]; other site 630626000971 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 630626000972 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 630626000973 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 630626000974 trimer interface [polypeptide binding]; other site 630626000975 putative metal binding site [ion binding]; other site 630626000976 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 630626000977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626000978 inhibitor-cofactor binding pocket; inhibition site 630626000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626000980 catalytic residue [active] 630626000981 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 630626000982 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 630626000983 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 630626000984 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 630626000985 FMN binding site [chemical binding]; other site 630626000986 active site 630626000987 catalytic residues [active] 630626000988 substrate binding site [chemical binding]; other site 630626000989 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 630626000990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 630626000991 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 630626000992 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 630626000993 Na binding site [ion binding]; other site 630626000994 Protein of unknown function (DUF997); Region: DUF997; cl01614 630626000995 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 630626000996 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 630626000997 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 630626000998 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 630626000999 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 630626001000 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 630626001001 carboxyltransferase (CT) interaction site; other site 630626001002 biotinylation site [posttranslational modification]; other site 630626001003 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 630626001004 Dehydroquinase class II; Region: DHquinase_II; pfam01220 630626001005 active site 630626001006 trimer interface [polypeptide binding]; other site 630626001007 dimer interface [polypeptide binding]; other site 630626001008 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 630626001009 TMAO/DMSO reductase; Reviewed; Region: PRK05363 630626001010 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 630626001011 Moco binding site; other site 630626001012 metal coordination site [ion binding]; other site 630626001013 regulatory protein CsrD; Provisional; Region: PRK11059 630626001014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626001015 metal binding site [ion binding]; metal-binding site 630626001016 active site 630626001017 I-site; other site 630626001018 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626001019 rod shape-determining protein MreB; Provisional; Region: PRK13927 630626001020 MreB and similar proteins; Region: MreB_like; cd10225 630626001021 nucleotide binding site [chemical binding]; other site 630626001022 Mg binding site [ion binding]; other site 630626001023 putative protofilament interaction site [polypeptide binding]; other site 630626001024 RodZ interaction site [polypeptide binding]; other site 630626001025 rod shape-determining protein MreC; Region: mreC; TIGR00219 630626001026 rod shape-determining protein MreC; Region: MreC; pfam04085 630626001027 rod shape-determining protein MreD; Provisional; Region: PRK11060 630626001028 Maf-like protein; Region: Maf; pfam02545 630626001029 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 630626001030 active site 630626001031 dimer interface [polypeptide binding]; other site 630626001032 ribonuclease G; Provisional; Region: PRK11712 630626001033 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 630626001034 homodimer interface [polypeptide binding]; other site 630626001035 oligonucleotide binding site [chemical binding]; other site 630626001036 hypothetical protein; Provisional; Region: PRK10899 630626001037 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 630626001038 protease TldD; Provisional; Region: tldD; PRK10735 630626001039 transcriptional regulator; Provisional; Region: PRK10632 630626001040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626001041 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626001042 putative effector binding pocket; other site 630626001043 dimerization interface [polypeptide binding]; other site 630626001044 efflux system membrane protein; Provisional; Region: PRK11594 630626001045 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 630626001046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626001047 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626001048 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 630626001049 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 630626001050 arginine repressor; Provisional; Region: PRK05066 630626001051 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 630626001052 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 630626001053 malate dehydrogenase; Provisional; Region: PRK05086 630626001054 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 630626001055 NAD binding site [chemical binding]; other site 630626001056 dimerization interface [polypeptide binding]; other site 630626001057 Substrate binding site [chemical binding]; other site 630626001058 serine endoprotease; Provisional; Region: PRK10898 630626001059 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 630626001060 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 630626001061 protein binding site [polypeptide binding]; other site 630626001062 serine endoprotease; Provisional; Region: PRK10139 630626001063 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 630626001064 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 630626001065 protein binding site [polypeptide binding]; other site 630626001066 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 630626001067 hypothetical protein; Provisional; Region: PRK11677 630626001068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 630626001069 Predicted ATPase [General function prediction only]; Region: COG1485 630626001070 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 630626001071 23S rRNA interface [nucleotide binding]; other site 630626001072 L3 interface [polypeptide binding]; other site 630626001073 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 630626001074 stringent starvation protein A; Provisional; Region: sspA; PRK09481 630626001075 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 630626001076 C-terminal domain interface [polypeptide binding]; other site 630626001077 putative GSH binding site (G-site) [chemical binding]; other site 630626001078 dimer interface [polypeptide binding]; other site 630626001079 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 630626001080 dimer interface [polypeptide binding]; other site 630626001081 N-terminal domain interface [polypeptide binding]; other site 630626001082 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 630626001083 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 630626001084 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626001085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 630626001086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626001087 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 630626001088 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 630626001089 active site 630626001090 dimer interface [polypeptide binding]; other site 630626001091 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 630626001092 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 630626001093 active site 630626001094 FMN binding site [chemical binding]; other site 630626001095 substrate binding site [chemical binding]; other site 630626001096 3Fe-4S cluster binding site [ion binding]; other site 630626001097 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 630626001098 domain interface; other site 630626001099 radical SAM protein, TIGR01212 family; Region: TIGR01212 630626001100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626001101 FeS/SAM binding site; other site 630626001102 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 630626001103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626001104 putative active site [active] 630626001105 heme pocket [chemical binding]; other site 630626001106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626001107 dimer interface [polypeptide binding]; other site 630626001108 phosphorylation site [posttranslational modification] 630626001109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626001110 ATP binding site [chemical binding]; other site 630626001111 Mg2+ binding site [ion binding]; other site 630626001112 G-X-G motif; other site 630626001113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626001114 active site 630626001115 phosphorylation site [posttranslational modification] 630626001116 intermolecular recognition site; other site 630626001117 dimerization interface [polypeptide binding]; other site 630626001118 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 630626001119 putative binding surface; other site 630626001120 active site 630626001121 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 630626001122 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 630626001123 conserved cys residue [active] 630626001124 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 630626001125 Transglycosylase; Region: Transgly; cl17702 630626001126 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 630626001127 dimerization domain swap beta strand [polypeptide binding]; other site 630626001128 regulatory protein interface [polypeptide binding]; other site 630626001129 active site 630626001130 regulatory phosphorylation site [posttranslational modification]; other site 630626001131 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 630626001132 AAA domain; Region: AAA_18; pfam13238 630626001133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 630626001134 active site 630626001135 phosphorylation site [posttranslational modification] 630626001136 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 630626001137 30S subunit binding site; other site 630626001138 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 630626001139 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 630626001140 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 630626001141 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 630626001142 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 630626001143 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 630626001144 Walker A/P-loop; other site 630626001145 ATP binding site [chemical binding]; other site 630626001146 Q-loop/lid; other site 630626001147 ABC transporter signature motif; other site 630626001148 Walker B; other site 630626001149 D-loop; other site 630626001150 H-loop/switch region; other site 630626001151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 630626001152 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 630626001153 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 630626001154 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 630626001155 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 630626001156 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 630626001157 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 630626001158 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 630626001159 putative active site [active] 630626001160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 630626001161 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 630626001162 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 630626001163 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 630626001164 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 630626001165 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 630626001166 Walker A/P-loop; other site 630626001167 ATP binding site [chemical binding]; other site 630626001168 Q-loop/lid; other site 630626001169 ABC transporter signature motif; other site 630626001170 Walker B; other site 630626001171 D-loop; other site 630626001172 H-loop/switch region; other site 630626001173 conserved hypothetical integral membrane protein; Region: TIGR00056 630626001174 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 630626001175 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 630626001176 mce related protein; Region: MCE; pfam02470 630626001177 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 630626001178 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 630626001179 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 630626001180 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 630626001181 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 630626001182 hinge; other site 630626001183 active site 630626001184 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 630626001185 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 630626001186 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 630626001187 substrate binding pocket [chemical binding]; other site 630626001188 chain length determination region; other site 630626001189 substrate-Mg2+ binding site; other site 630626001190 catalytic residues [active] 630626001191 aspartate-rich region 1; other site 630626001192 active site lid residues [active] 630626001193 aspartate-rich region 2; other site 630626001194 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 630626001195 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 630626001196 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 630626001197 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 630626001198 EamA-like transporter family; Region: EamA; pfam00892 630626001199 GTPase CgtA; Reviewed; Region: obgE; PRK12298 630626001200 GTP1/OBG; Region: GTP1_OBG; pfam01018 630626001201 Obg GTPase; Region: Obg; cd01898 630626001202 G1 box; other site 630626001203 GTP/Mg2+ binding site [chemical binding]; other site 630626001204 Switch I region; other site 630626001205 G2 box; other site 630626001206 G3 box; other site 630626001207 Switch II region; other site 630626001208 G4 box; other site 630626001209 G5 box; other site 630626001210 sensor protein BasS/PmrB; Provisional; Region: PRK10755 630626001211 HAMP domain; Region: HAMP; pfam00672 630626001212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626001213 dimer interface [polypeptide binding]; other site 630626001214 phosphorylation site [posttranslational modification] 630626001215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626001216 ATP binding site [chemical binding]; other site 630626001217 Mg2+ binding site [ion binding]; other site 630626001218 G-X-G motif; other site 630626001219 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 630626001220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626001221 active site 630626001222 phosphorylation site [posttranslational modification] 630626001223 intermolecular recognition site; other site 630626001224 dimerization interface [polypeptide binding]; other site 630626001225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626001226 DNA binding site [nucleotide binding] 630626001227 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 630626001228 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 630626001229 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 630626001230 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 630626001231 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 630626001232 RNA-binding protein YhbY; Provisional; Region: PRK10343 630626001233 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 630626001234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626001235 S-adenosylmethionine binding site [chemical binding]; other site 630626001236 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 630626001237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626001238 Walker A motif; other site 630626001239 ATP binding site [chemical binding]; other site 630626001240 Walker B motif; other site 630626001241 arginine finger; other site 630626001242 Peptidase family M41; Region: Peptidase_M41; pfam01434 630626001243 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 630626001244 dihydropteroate synthase; Region: DHPS; TIGR01496 630626001245 substrate binding pocket [chemical binding]; other site 630626001246 dimer interface [polypeptide binding]; other site 630626001247 inhibitor binding site; inhibition site 630626001248 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 630626001249 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 630626001250 active site 630626001251 substrate binding site [chemical binding]; other site 630626001252 metal binding site [ion binding]; metal-binding site 630626001253 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 630626001254 isoaspartyl dipeptidase; Provisional; Region: PRK10657 630626001255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 630626001256 active site 630626001257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626001258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626001259 LysR substrate binding domain; Region: LysR_substrate; pfam03466 630626001260 dimerization interface [polypeptide binding]; other site 630626001261 Preprotein translocase SecG subunit; Region: SecG; pfam03840 630626001262 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 630626001263 Helix-turn-helix domain; Region: HTH_18; pfam12833 630626001264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626001265 argininosuccinate synthase; Validated; Region: PRK05370 630626001266 argininosuccinate synthase; Provisional; Region: PRK13820 630626001267 ribosome maturation protein RimP; Reviewed; Region: PRK00092 630626001268 hypothetical protein; Provisional; Region: PRK14641 630626001269 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 630626001270 putative oligomer interface [polypeptide binding]; other site 630626001271 putative RNA binding site [nucleotide binding]; other site 630626001272 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 630626001273 NusA N-terminal domain; Region: NusA_N; pfam08529 630626001274 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 630626001275 RNA binding site [nucleotide binding]; other site 630626001276 homodimer interface [polypeptide binding]; other site 630626001277 NusA-like KH domain; Region: KH_5; pfam13184 630626001278 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 630626001279 G-X-X-G motif; other site 630626001280 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 630626001281 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 630626001282 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 630626001283 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 630626001284 translation initiation factor IF-2; Region: IF-2; TIGR00487 630626001285 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 630626001286 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 630626001287 G1 box; other site 630626001288 putative GEF interaction site [polypeptide binding]; other site 630626001289 GTP/Mg2+ binding site [chemical binding]; other site 630626001290 Switch I region; other site 630626001291 G2 box; other site 630626001292 G3 box; other site 630626001293 Switch II region; other site 630626001294 G4 box; other site 630626001295 G5 box; other site 630626001296 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 630626001297 Translation-initiation factor 2; Region: IF-2; pfam11987 630626001298 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 630626001299 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 630626001300 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 630626001301 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 630626001302 RNA binding site [nucleotide binding]; other site 630626001303 active site 630626001304 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 630626001305 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 630626001306 16S/18S rRNA binding site [nucleotide binding]; other site 630626001307 S13e-L30e interaction site [polypeptide binding]; other site 630626001308 25S rRNA binding site [nucleotide binding]; other site 630626001309 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 630626001310 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 630626001311 RNase E interface [polypeptide binding]; other site 630626001312 trimer interface [polypeptide binding]; other site 630626001313 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 630626001314 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 630626001315 RNase E interface [polypeptide binding]; other site 630626001316 trimer interface [polypeptide binding]; other site 630626001317 active site 630626001318 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 630626001319 putative nucleic acid binding region [nucleotide binding]; other site 630626001320 G-X-X-G motif; other site 630626001321 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 630626001322 RNA binding site [nucleotide binding]; other site 630626001323 domain interface; other site 630626001324 lipoprotein NlpI; Provisional; Region: PRK11189 630626001325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626001326 binding surface 630626001327 TPR motif; other site 630626001328 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 630626001329 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 630626001330 ATP binding site [chemical binding]; other site 630626001331 Mg++ binding site [ion binding]; other site 630626001332 motif III; other site 630626001333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626001334 nucleotide binding region [chemical binding]; other site 630626001335 ATP-binding site [chemical binding]; other site 630626001336 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 630626001337 putative RNA binding site [nucleotide binding]; other site 630626001338 tryptophan permease; Provisional; Region: PRK10483 630626001339 aromatic amino acid transport protein; Region: araaP; TIGR00837 630626001340 putative transposase; Provisional; Region: PRK09857 630626001341 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 630626001342 CblD like pilus biogenesis initiator; Region: CblD; cl06460 630626001343 CblD like pilus biogenesis initiator; Region: CblD; cl06460 630626001344 CblD like pilus biogenesis initiator; Region: CblD; cl06460 630626001345 hypothetical protein; Provisional; Region: PRK10508 630626001346 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 630626001347 putative protease; Provisional; Region: PRK15447 630626001348 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 630626001349 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 630626001350 Peptidase family U32; Region: Peptidase_U32; pfam01136 630626001351 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 630626001352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626001353 Coenzyme A binding pocket [chemical binding]; other site 630626001354 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 630626001355 GIY-YIG motif/motif A; other site 630626001356 putative active site [active] 630626001357 putative metal binding site [ion binding]; other site 630626001358 hypothetical protein; Provisional; Region: PRK03467 630626001359 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 630626001360 NADH(P)-binding; Region: NAD_binding_10; pfam13460 630626001361 NAD binding site [chemical binding]; other site 630626001362 active site 630626001363 outer membrane lipoprotein; Provisional; Region: PRK11023 630626001364 BON domain; Region: BON; pfam04972 630626001365 BON domain; Region: BON; pfam04972 630626001366 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 630626001367 dimer interface [polypeptide binding]; other site 630626001368 active site 630626001369 hypothetical protein; Reviewed; Region: PRK12497 630626001370 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 630626001371 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 630626001372 putative ligand binding site [chemical binding]; other site 630626001373 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 630626001374 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 630626001375 putative SAM binding site [chemical binding]; other site 630626001376 putative homodimer interface [polypeptide binding]; other site 630626001377 Fic family protein [Function unknown]; Region: COG3177 630626001378 Fic/DOC family; Region: Fic; pfam02661 630626001379 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 630626001380 galactarate dehydratase; Region: galactar-dH20; TIGR03248 630626001381 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 630626001382 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 630626001383 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 630626001384 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 630626001385 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 630626001386 Pirin-related protein [General function prediction only]; Region: COG1741 630626001387 Pirin; Region: Pirin; pfam02678 630626001388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626001389 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 630626001390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626001391 dimerization interface [polypeptide binding]; other site 630626001392 Predicted membrane protein [Function unknown]; Region: COG3152 630626001393 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 630626001394 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 630626001395 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 630626001396 putative dimer interface [polypeptide binding]; other site 630626001397 N-terminal domain interface [polypeptide binding]; other site 630626001398 putative substrate binding pocket (H-site) [chemical binding]; other site 630626001399 Predicted membrane protein [Function unknown]; Region: COG2259 630626001400 YqjK-like protein; Region: YqjK; pfam13997 630626001401 Predicted membrane protein [Function unknown]; Region: COG5393 630626001402 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 630626001403 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 630626001404 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 630626001405 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 630626001406 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 630626001407 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 630626001408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626001409 DNA-binding site [nucleotide binding]; DNA binding site 630626001410 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626001411 D-galactonate transporter; Region: 2A0114; TIGR00893 630626001412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626001413 putative substrate translocation pore; other site 630626001414 Glucuronate isomerase; Region: UxaC; pfam02614 630626001415 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 630626001416 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 630626001417 galactarate dehydratase; Region: galactar-dH20; TIGR03248 630626001418 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 630626001419 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 630626001420 serine/threonine transporter SstT; Provisional; Region: PRK13628 630626001421 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 630626001422 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 630626001423 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 630626001424 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 630626001425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626001426 S-adenosylmethionine binding site [chemical binding]; other site 630626001427 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 630626001428 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 630626001429 active site 630626001430 FMN binding site [chemical binding]; other site 630626001431 2,4-decadienoyl-CoA binding site; other site 630626001432 catalytic residue [active] 630626001433 4Fe-4S cluster binding site [ion binding]; other site 630626001434 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 630626001435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 630626001436 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 630626001437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626001438 inhibitor-cofactor binding pocket; inhibition site 630626001439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626001440 catalytic residue [active] 630626001441 diguanylate cyclase; Provisional; Region: PRK09894 630626001442 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 630626001443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626001444 metal binding site [ion binding]; metal-binding site 630626001445 active site 630626001446 I-site; other site 630626001447 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 630626001448 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 630626001449 FAD binding pocket [chemical binding]; other site 630626001450 FAD binding motif [chemical binding]; other site 630626001451 phosphate binding motif [ion binding]; other site 630626001452 NAD binding pocket [chemical binding]; other site 630626001453 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 630626001454 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 630626001455 active site 630626001456 metal binding site [ion binding]; metal-binding site 630626001457 nudix motif; other site 630626001458 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 630626001459 Flavoprotein; Region: Flavoprotein; pfam02441 630626001460 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 630626001461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626001462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626001463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 630626001464 dimerization interface [polypeptide binding]; other site 630626001465 high-affinity gluconate transporter; Provisional; Region: PRK14984 630626001466 gluconate transporter; Region: gntP; TIGR00791 630626001467 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 630626001468 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 630626001469 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 630626001470 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 630626001471 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 630626001472 active site 630626001473 polysaccharide export protein Wza; Provisional; Region: PRK15078 630626001474 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 630626001475 SLBB domain; Region: SLBB; pfam10531 630626001476 Low molecular weight phosphatase family; Region: LMWPc; cd00115 630626001477 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 630626001478 active site 630626001479 tyrosine kinase; Provisional; Region: PRK11519 630626001480 Chain length determinant protein; Region: Wzz; pfam02706 630626001481 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 630626001482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 630626001483 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 630626001484 Bacterial sugar transferase; Region: Bac_transf; pfam02397 630626001485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626001486 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 630626001487 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 630626001488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626001489 O-Antigen ligase; Region: Wzy_C; pfam04932 630626001490 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 630626001491 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 630626001492 Substrate binding site; other site 630626001493 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 630626001494 phosphomannomutase CpsG; Provisional; Region: PRK15414 630626001495 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 630626001496 active site 630626001497 substrate binding site [chemical binding]; other site 630626001498 metal binding site [ion binding]; metal-binding site 630626001499 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 630626001500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626001501 putative ADP-binding pocket [chemical binding]; other site 630626001502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626001503 active site 630626001504 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 630626001505 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 630626001506 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 630626001507 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 630626001508 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 630626001509 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 630626001510 Acyltransferase family; Region: Acyl_transf_3; pfam01757 630626001511 HTH-like domain; Region: HTH_21; pfam13276 630626001512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626001513 Integrase core domain; Region: rve; pfam00665 630626001514 Integrase core domain; Region: rve_3; pfam13683 630626001515 Transposase; Region: HTH_Tnp_1; pfam01527 630626001516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626001517 Integrase core domain; Region: rve; pfam00665 630626001518 Integrase core domain; Region: rve_3; pfam13683 630626001519 HTH-like domain; Region: HTH_21; pfam13276 630626001520 Transposase; Region: DEDD_Tnp_IS110; pfam01548 630626001521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 630626001522 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 630626001523 Transposase; Region: HTH_Tnp_1; cl17663 630626001524 Transposase; Region: HTH_Tnp_1; cl17663 630626001525 Homeodomain-like domain; Region: HTH_32; pfam13565 630626001526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626001527 Integrase core domain; Region: rve; pfam00665 630626001528 Integrase core domain; Region: rve_3; pfam13683 630626001529 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 630626001530 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 630626001531 P-loop; other site 630626001532 Magnesium ion binding site [ion binding]; other site 630626001533 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 630626001534 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 630626001535 DXD motif; other site 630626001536 PilZ domain; Region: PilZ; pfam07238 630626001537 cellulose synthase regulator protein; Provisional; Region: PRK11114 630626001538 Tetratricopeptide repeat; Region: TPR_16; pfam13432 630626001539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626001540 TPR motif; other site 630626001541 binding surface 630626001542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626001543 binding surface 630626001544 Tetratricopeptide repeat; Region: TPR_16; pfam13432 630626001545 TPR motif; other site 630626001546 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 630626001547 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 630626001548 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 630626001549 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 630626001550 putative transposase; Provisional; Region: PRK09857 630626001551 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 630626001552 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 630626001553 Bacterial sugar transferase; Region: Bac_transf; pfam02397 630626001554 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 630626001555 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 630626001556 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 630626001557 SLBB domain; Region: SLBB; pfam10531 630626001558 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 630626001559 Chain length determinant protein; Region: Wzz; pfam02706 630626001560 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 630626001561 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 630626001562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626001563 active site 630626001564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626001565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 630626001566 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 630626001567 UDP-glucose 4-epimerase; Region: PLN02240 630626001568 NAD binding site [chemical binding]; other site 630626001569 homodimer interface [polypeptide binding]; other site 630626001570 active site 630626001571 substrate binding site [chemical binding]; other site 630626001572 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 630626001573 active site 630626001574 SUMO-1 interface [polypeptide binding]; other site 630626001575 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 630626001576 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 630626001577 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 630626001578 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 630626001579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 630626001580 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 630626001581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 630626001582 DNA binding residues [nucleotide binding] 630626001583 DNA primase; Validated; Region: dnaG; PRK05667 630626001584 CHC2 zinc finger; Region: zf-CHC2; pfam01807 630626001585 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 630626001586 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 630626001587 active site 630626001588 metal binding site [ion binding]; metal-binding site 630626001589 interdomain interaction site; other site 630626001590 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 630626001591 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 630626001592 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 630626001593 UGMP family protein; Validated; Region: PRK09604 630626001594 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 630626001595 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 630626001596 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 630626001597 homooctamer interface [polypeptide binding]; other site 630626001598 active site 630626001599 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 630626001600 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 630626001601 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 630626001602 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 630626001603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626001604 Zn2+ binding site [ion binding]; other site 630626001605 Mg2+ binding site [ion binding]; other site 630626001606 SH3 domain-containing protein; Provisional; Region: PRK10884 630626001607 Bacterial SH3 domain homologues; Region: SH3b; smart00287 630626001608 Uncharacterized conserved protein [Function unknown]; Region: COG3025 630626001609 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 630626001610 putative active site [active] 630626001611 putative metal binding residues [ion binding]; other site 630626001612 signature motif; other site 630626001613 putative triphosphate binding site [ion binding]; other site 630626001614 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 630626001615 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 630626001616 metal binding triad; other site 630626001617 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 630626001618 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 630626001619 metal binding triad; other site 630626001620 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 630626001621 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 630626001622 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 630626001623 putative ribose interaction site [chemical binding]; other site 630626001624 putative ADP binding site [chemical binding]; other site 630626001625 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 630626001626 active site 630626001627 nucleotide binding site [chemical binding]; other site 630626001628 HIGH motif; other site 630626001629 KMSKS motif; other site 630626001630 Glycogen synthesis protein; Region: GlgS; cl11663 630626001631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 630626001632 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 630626001633 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 630626001634 zinc transporter ZupT; Provisional; Region: PRK04201 630626001635 ZIP Zinc transporter; Region: Zip; pfam02535 630626001636 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 630626001637 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 630626001638 putative active site [active] 630626001639 metal binding site [ion binding]; metal-binding site 630626001640 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 630626001641 hypothetical protein; Provisional; Region: PRK11653 630626001642 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 630626001643 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 630626001644 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 630626001645 dimer interface [polypeptide binding]; other site 630626001646 ADP-ribose binding site [chemical binding]; other site 630626001647 active site 630626001648 nudix motif; other site 630626001649 metal binding site [ion binding]; metal-binding site 630626001650 putative dehydrogenase; Provisional; Region: PRK11039 630626001651 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 630626001652 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 630626001653 active site 630626001654 metal binding site [ion binding]; metal-binding site 630626001655 hexamer interface [polypeptide binding]; other site 630626001656 esterase YqiA; Provisional; Region: PRK11071 630626001657 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 630626001658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626001659 ATP binding site [chemical binding]; other site 630626001660 Mg2+ binding site [ion binding]; other site 630626001661 G-X-G motif; other site 630626001662 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 630626001663 anchoring element; other site 630626001664 dimer interface [polypeptide binding]; other site 630626001665 ATP binding site [chemical binding]; other site 630626001666 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 630626001667 active site 630626001668 metal binding site [ion binding]; metal-binding site 630626001669 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 630626001670 Cation transport protein; Region: TrkH; cl17365 630626001671 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 630626001672 Uncharacterized conserved protein [Function unknown]; Region: COG1359 630626001673 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 630626001674 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 630626001675 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 630626001676 CAP-like domain; other site 630626001677 active site 630626001678 primary dimer interface [polypeptide binding]; other site 630626001679 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 630626001680 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 630626001681 putative acyl-acceptor binding pocket; other site 630626001682 FtsI repressor; Provisional; Region: PRK10883 630626001683 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 630626001684 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 630626001685 HemN family oxidoreductase; Provisional; Region: PRK05660 630626001686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626001687 FeS/SAM binding site; other site 630626001688 HemN C-terminal domain; Region: HemN_C; pfam06969 630626001689 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 630626001690 active site 630626001691 dimerization interface [polypeptide binding]; other site 630626001692 hypothetical protein; Validated; Region: PRK05090 630626001693 YGGT family; Region: YGGT; pfam02325 630626001694 YGGT family; Region: YGGT; pfam02325 630626001695 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 630626001696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626001697 catalytic residue [active] 630626001698 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 630626001699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 630626001700 Walker A motif; other site 630626001701 ATP binding site [chemical binding]; other site 630626001702 Walker B motif; other site 630626001703 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 630626001704 hypothetical protein; Validated; Region: PRK00228 630626001705 glutathione synthetase; Provisional; Region: PRK05246 630626001706 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 630626001707 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 630626001708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 630626001709 RNA methyltransferase, RsmE family; Region: TIGR00046 630626001710 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 630626001711 DNA-specific endonuclease I; Provisional; Region: PRK15137 630626001712 hypothetical protein; Provisional; Region: PRK04860 630626001713 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 630626001714 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 630626001715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626001716 putative substrate translocation pore; other site 630626001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626001718 S-adenosylmethionine synthetase; Validated; Region: PRK05250 630626001719 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 630626001720 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 630626001721 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 630626001722 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 630626001723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 630626001724 dimer interface [polypeptide binding]; other site 630626001725 active site 630626001726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626001727 catalytic residues [active] 630626001728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 630626001729 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 630626001730 agmatinase; Region: agmatinase; TIGR01230 630626001731 oligomer interface [polypeptide binding]; other site 630626001732 putative active site [active] 630626001733 Mn binding site [ion binding]; other site 630626001734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626001735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626001736 putative substrate translocation pore; other site 630626001737 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 630626001738 [2Fe-2S] cluster binding site [ion binding]; other site 630626001739 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 630626001740 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 630626001741 [2Fe-2S] cluster binding site [ion binding]; other site 630626001742 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 630626001743 hydrophobic ligand binding site; other site 630626001744 short chain dehydrogenase; Provisional; Region: PRK12939 630626001745 classical (c) SDRs; Region: SDR_c; cd05233 630626001746 NAD(P) binding site [chemical binding]; other site 630626001747 active site 630626001748 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 630626001749 Transcriptional regulator [Transcription]; Region: IclR; COG1414 630626001750 Bacterial transcriptional regulator; Region: IclR; pfam01614 630626001751 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 630626001752 active site 630626001753 metal binding site [ion binding]; metal-binding site 630626001754 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 630626001755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 630626001756 putative active site [active] 630626001757 putative metal binding site [ion binding]; other site 630626001758 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 630626001759 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626001760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626001761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626001762 D-galactonate transporter; Region: 2A0114; TIGR00893 630626001763 putative substrate translocation pore; other site 630626001764 Cupin domain; Region: Cupin_2; pfam07883 630626001765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 630626001766 short chain dehydrogenase; Provisional; Region: PRK07062 630626001767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626001768 NAD(P) binding site [chemical binding]; other site 630626001769 active site 630626001770 L-aspartate dehydrogenase; Provisional; Region: PRK13303 630626001771 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 630626001772 Domain of unknown function DUF108; Region: DUF108; pfam01958 630626001773 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 630626001774 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 630626001775 NAD(P) binding site [chemical binding]; other site 630626001776 catalytic residues [active] 630626001777 hypothetical protein; Provisional; Region: PRK07064 630626001778 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 630626001779 PYR/PP interface [polypeptide binding]; other site 630626001780 dimer interface [polypeptide binding]; other site 630626001781 TPP binding site [chemical binding]; other site 630626001782 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 630626001783 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 630626001784 TPP-binding site [chemical binding]; other site 630626001785 outer membrane porin, OprD family; Region: OprD; pfam03573 630626001786 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 630626001787 transketolase; Reviewed; Region: PRK12753 630626001788 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 630626001789 TPP-binding site [chemical binding]; other site 630626001790 dimer interface [polypeptide binding]; other site 630626001791 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 630626001792 PYR/PP interface [polypeptide binding]; other site 630626001793 dimer interface [polypeptide binding]; other site 630626001794 TPP binding site [chemical binding]; other site 630626001795 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 630626001796 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 630626001797 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 630626001798 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 630626001799 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 630626001800 Phosphoglycerate kinase; Region: PGK; pfam00162 630626001801 substrate binding site [chemical binding]; other site 630626001802 hinge regions; other site 630626001803 ADP binding site [chemical binding]; other site 630626001804 catalytic site [active] 630626001805 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 630626001806 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 630626001807 active site 630626001808 intersubunit interface [polypeptide binding]; other site 630626001809 zinc binding site [ion binding]; other site 630626001810 Na+ binding site [ion binding]; other site 630626001811 mechanosensitive channel MscS; Provisional; Region: PRK10334 630626001812 Conserved TM helix; Region: TM_helix; pfam05552 630626001813 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626001814 arginine exporter protein; Provisional; Region: PRK09304 630626001815 Uncharacterized conserved protein [Function unknown]; Region: COG2968 630626001816 oxidative stress defense protein; Provisional; Region: PRK11087 630626001817 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 630626001818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626001819 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 630626001820 putative dimerization interface [polypeptide binding]; other site 630626001821 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 630626001822 tetramer (dimer of dimers) interface [polypeptide binding]; other site 630626001823 active site 630626001824 dimer interface [polypeptide binding]; other site 630626001825 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 630626001826 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 630626001827 ligand binding site [chemical binding]; other site 630626001828 NAD binding site [chemical binding]; other site 630626001829 tetramer interface [polypeptide binding]; other site 630626001830 catalytic site [active] 630626001831 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 630626001832 L-serine binding site [chemical binding]; other site 630626001833 ACT domain interface; other site 630626001834 hypothetical protein; Provisional; Region: PRK01254 630626001835 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 630626001836 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 630626001837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 630626001838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 630626001839 active site 630626001840 catalytic tetrad [active] 630626001841 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 630626001842 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 630626001843 dimer interface [polypeptide binding]; other site 630626001844 active site 630626001845 metal binding site [ion binding]; metal-binding site 630626001846 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 630626001847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626001848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 630626001849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626001850 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 630626001851 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 630626001852 cystathionine beta-lyase; Provisional; Region: PRK08114 630626001853 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 630626001854 homodimer interface [polypeptide binding]; other site 630626001855 substrate-cofactor binding pocket; other site 630626001856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626001857 catalytic residue [active] 630626001858 biopolymer transport protein ExbB; Provisional; Region: PRK10414 630626001859 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 630626001860 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 630626001861 maltose O-acetyltransferase; Provisional; Region: PRK10092 630626001862 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 630626001863 active site 630626001864 substrate binding site [chemical binding]; other site 630626001865 trimer interface [polypeptide binding]; other site 630626001866 CoA binding site [chemical binding]; other site 630626001867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 630626001868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 630626001869 active site 630626001870 catalytic tetrad [active] 630626001871 malate:quinone oxidoreductase; Validated; Region: PRK05257 630626001872 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 630626001873 putative S-transferase; Provisional; Region: PRK11752 630626001874 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 630626001875 C-terminal domain interface [polypeptide binding]; other site 630626001876 GSH binding site (G-site) [chemical binding]; other site 630626001877 dimer interface [polypeptide binding]; other site 630626001878 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 630626001879 N-terminal domain interface [polypeptide binding]; other site 630626001880 dimer interface [polypeptide binding]; other site 630626001881 substrate binding pocket (H-site) [chemical binding]; other site 630626001882 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 630626001883 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 630626001884 P-loop, Walker A motif; other site 630626001885 Base recognition motif; other site 630626001886 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 630626001887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626001888 Zn2+ binding site [ion binding]; other site 630626001889 Mg2+ binding site [ion binding]; other site 630626001890 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626001891 Zn2+ binding site [ion binding]; other site 630626001892 Mg2+ binding site [ion binding]; other site 630626001893 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 630626001894 dimer interface [polypeptide binding]; other site 630626001895 catalytic triad [active] 630626001896 peroxidatic and resolving cysteines [active] 630626001897 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 630626001898 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 630626001899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 630626001900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626001901 DNA-binding site [nucleotide binding]; DNA binding site 630626001902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626001903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626001904 homodimer interface [polypeptide binding]; other site 630626001905 catalytic residue [active] 630626001906 Uncharacterized conserved protein [Function unknown]; Region: COG2128 630626001907 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 630626001908 Transposase; Region: HTH_Tnp_1; cl17663 630626001909 Homeodomain-like domain; Region: HTH_32; pfam13565 630626001910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626001911 Integrase core domain; Region: rve; pfam00665 630626001912 Integrase core domain; Region: rve_3; pfam13683 630626001913 Protein of unknown function (DUF523); Region: DUF523; cl00733 630626001914 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 630626001915 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 630626001916 HTH-like domain; Region: HTH_21; pfam13276 630626001917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626001918 Integrase core domain; Region: rve; pfam00665 630626001919 Integrase core domain; Region: rve_3; pfam13683 630626001920 Transposase; Region: HTH_Tnp_1; pfam01527 630626001921 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 630626001922 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 630626001923 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 630626001924 active site 630626001925 Integrase core domain; Region: rve_3; cl15866 630626001926 Transposase; Region: DEDD_Tnp_IS110; pfam01548 630626001927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 630626001928 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 630626001929 HTH-like domain; Region: HTH_21; pfam13276 630626001930 Integrase core domain; Region: rve; pfam00665 630626001931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626001932 Transposase; Region: HTH_Tnp_1; cl17663 630626001933 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 630626001934 ornithine decarboxylase; Provisional; Region: PRK13578 630626001935 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 630626001936 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 630626001937 homodimer interface [polypeptide binding]; other site 630626001938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626001939 catalytic residue [active] 630626001940 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 630626001941 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 630626001942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626001943 active site 630626001944 phosphorylation site [posttranslational modification] 630626001945 intermolecular recognition site; other site 630626001946 dimerization interface [polypeptide binding]; other site 630626001947 Transcriptional regulator; Region: CitT; pfam12431 630626001948 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 630626001949 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 630626001950 PAS domain; Region: PAS; smart00091 630626001951 putative active site [active] 630626001952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626001953 ATP binding site [chemical binding]; other site 630626001954 Mg2+ binding site [ion binding]; other site 630626001955 G-X-G motif; other site 630626001956 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 630626001957 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 630626001958 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 630626001959 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 630626001960 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 630626001961 active site 630626001962 nucleotide binding site [chemical binding]; other site 630626001963 HIGH motif; other site 630626001964 KMSKS motif; other site 630626001965 citrate lyase subunit gamma; Provisional; Region: PRK13253 630626001966 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 630626001967 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 630626001968 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 630626001969 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 630626001970 Hok/gef family; Region: HOK_GEF; cl11494 630626001971 Hok/gef family; Region: HOK_GEF; cl11494 630626001972 murein transglycosylase C; Provisional; Region: mltC; PRK11671 630626001973 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 630626001974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626001975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626001976 catalytic residue [active] 630626001977 oxidative damage protection protein; Provisional; Region: PRK05408 630626001978 adenine DNA glycosylase; Provisional; Region: PRK10880 630626001979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 630626001980 minor groove reading motif; other site 630626001981 helix-hairpin-helix signature motif; other site 630626001982 substrate binding pocket [chemical binding]; other site 630626001983 active site 630626001984 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 630626001985 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 630626001986 DNA binding and oxoG recognition site [nucleotide binding] 630626001987 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 630626001988 hypothetical protein; Provisional; Region: PRK11702 630626001989 hypothetical protein; Provisional; Region: PRK10626 630626001990 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 630626001991 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 630626001992 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 630626001993 Z-ring-associated protein; Provisional; Region: PRK10972 630626001994 hypothetical protein; Reviewed; Region: PRK01736 630626001995 proline aminopeptidase P II; Provisional; Region: PRK10879 630626001996 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 630626001997 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 630626001998 active site 630626001999 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 630626002000 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 630626002001 oxidoreductase; Provisional; Region: PRK08013 630626002002 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 630626002003 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 630626002004 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 630626002005 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 630626002006 lipoyl attachment site [posttranslational modification]; other site 630626002007 glycine dehydrogenase; Provisional; Region: PRK05367 630626002008 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 630626002009 tetramer interface [polypeptide binding]; other site 630626002010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626002011 catalytic residue [active] 630626002012 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 630626002013 tetramer interface [polypeptide binding]; other site 630626002014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626002015 catalytic residue [active] 630626002016 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 630626002017 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 630626002018 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 630626002019 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626002020 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626002021 putative active site [active] 630626002022 D-allose transporter subunit; Provisional; Region: PRK09701 630626002023 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 630626002024 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 630626002025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626002026 Walker A/P-loop; other site 630626002027 ATP binding site [chemical binding]; other site 630626002028 Q-loop/lid; other site 630626002029 ABC transporter signature motif; other site 630626002030 Walker B; other site 630626002031 D-loop; other site 630626002032 H-loop/switch region; other site 630626002033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 630626002034 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626002035 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626002036 TM-ABC transporter signature motif; other site 630626002037 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 630626002038 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 630626002039 substrate binding site [chemical binding]; other site 630626002040 hexamer interface [polypeptide binding]; other site 630626002041 metal binding site [ion binding]; metal-binding site 630626002042 D-allose kinase; Provisional; Region: PRK09698 630626002043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626002044 nucleotide binding site [chemical binding]; other site 630626002045 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 630626002046 classical (c) SDRs; Region: SDR_c; cd05233 630626002047 NAD(P) binding site [chemical binding]; other site 630626002048 active site 630626002049 hemolysin; Provisional; Region: PRK15087 630626002050 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 630626002051 HD domain; Region: HD_3; pfam13023 630626002052 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 630626002053 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626002054 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626002055 putative active site [active] 630626002056 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 630626002057 beta-galactosidase; Region: BGL; TIGR03356 630626002058 putative global regulator; Reviewed; Region: PRK09559 630626002059 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 630626002060 hypothetical protein; Provisional; Region: PRK10878 630626002061 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 630626002062 flavodoxin FldB; Provisional; Region: PRK12359 630626002063 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 630626002064 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 630626002065 active site 630626002066 Int/Topo IB signature motif; other site 630626002067 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 630626002068 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 630626002069 dimerization domain [polypeptide binding]; other site 630626002070 dimer interface [polypeptide binding]; other site 630626002071 catalytic residues [active] 630626002072 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 630626002073 DHH family; Region: DHH; pfam01368 630626002074 DHHA1 domain; Region: DHHA1; pfam02272 630626002075 peptide chain release factor 2; Provisional; Region: PRK08787 630626002076 This domain is found in peptide chain release factors; Region: PCRF; smart00937 630626002077 RF-1 domain; Region: RF-1; pfam00472 630626002078 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 630626002079 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 630626002080 dimer interface [polypeptide binding]; other site 630626002081 putative anticodon binding site; other site 630626002082 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 630626002083 motif 1; other site 630626002084 active site 630626002085 motif 2; other site 630626002086 motif 3; other site 630626002087 Transposase IS200 like; Region: Y1_Tnp; pfam01797 630626002088 Transcriptional regulators [Transcription]; Region: FadR; COG2186 630626002089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626002090 DNA-binding site [nucleotide binding]; DNA binding site 630626002091 FCD domain; Region: FCD; pfam07729 630626002092 Transposase; Region: HTH_Tnp_1; cl17663 630626002093 Homeodomain-like domain; Region: HTH_32; pfam13565 630626002094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626002095 Integrase core domain; Region: rve; pfam00665 630626002096 Integrase core domain; Region: rve_3; pfam13683 630626002097 Integrase core domain; Region: rve_3; cl15866 630626002098 Transposase; Region: DEDD_Tnp_IS110; pfam01548 630626002099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 630626002100 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 630626002101 HTH-like domain; Region: HTH_21; pfam13276 630626002102 Integrase core domain; Region: rve; pfam00665 630626002103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626002104 Transposase; Region: HTH_Tnp_1; pfam01527 630626002105 Predicted amidohydrolase [General function prediction only]; Region: COG0388 630626002106 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 630626002107 putative active site [active] 630626002108 catalytic triad [active] 630626002109 putative dimer interface [polypeptide binding]; other site 630626002110 hypothetical protein; Validated; Region: PRK06201 630626002111 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 630626002112 D-galactonate transporter; Region: 2A0114; TIGR00893 630626002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002114 putative substrate translocation pore; other site 630626002115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626002116 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 630626002117 Peptidase family M23; Region: Peptidase_M23; pfam01551 630626002118 HTH-like domain; Region: HTH_21; pfam13276 630626002119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626002120 Integrase core domain; Region: rve; pfam00665 630626002121 Transposase; Region: HTH_Tnp_1; pfam01527 630626002122 BCCT family transporter; Region: BCCT; cl00569 630626002123 Homeodomain-like domain; Region: HTH_32; pfam13565 630626002124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626002125 Integrase core domain; Region: rve; pfam00665 630626002126 Integrase core domain; Region: rve_3; pfam13683 630626002127 Transposase; Region: HTH_Tnp_1; cl17663 630626002128 alanine-tRNA ligase; Region: PLN02961 630626002129 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 630626002130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 630626002131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626002132 non-specific DNA binding site [nucleotide binding]; other site 630626002133 salt bridge; other site 630626002134 sequence-specific DNA binding site [nucleotide binding]; other site 630626002135 Cupin domain; Region: Cupin_2; pfam07883 630626002136 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 630626002137 L-lactate permease; Region: Lactate_perm; cl00701 630626002138 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 630626002139 Cysteine-rich domain; Region: CCG; pfam02754 630626002140 Cysteine-rich domain; Region: CCG; pfam02754 630626002141 iron-sulfur cluster-binding protein; Region: TIGR00273 630626002142 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 630626002143 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626002144 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 630626002145 Uncharacterized conserved protein [Function unknown]; Region: COG1556 630626002146 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 630626002147 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 630626002148 ATP-binding site [chemical binding]; other site 630626002149 Gluconate-6-phosphate binding site [chemical binding]; other site 630626002150 Shikimate kinase; Region: SKI; pfam01202 630626002151 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 630626002152 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 630626002153 NADP binding site [chemical binding]; other site 630626002154 homodimer interface [polypeptide binding]; other site 630626002155 active site 630626002156 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 630626002157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626002158 DNA binding site [nucleotide binding] 630626002159 domain linker motif; other site 630626002160 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 630626002161 putative ligand binding site [chemical binding]; other site 630626002162 putative dimerization interface [polypeptide binding]; other site 630626002163 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 630626002164 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 630626002165 putative ligand binding site [chemical binding]; other site 630626002166 NAD binding site [chemical binding]; other site 630626002167 catalytic site [active] 630626002168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002169 D-galactonate transporter; Region: 2A0114; TIGR00893 630626002170 putative substrate translocation pore; other site 630626002171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002172 hypothetical protein; Provisional; Region: PRK02487 630626002173 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 630626002174 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 630626002175 intersubunit interface [polypeptide binding]; other site 630626002176 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626002177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626002178 ABC-ATPase subunit interface; other site 630626002179 dimer interface [polypeptide binding]; other site 630626002180 putative PBP binding regions; other site 630626002181 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 630626002182 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626002183 Walker A/P-loop; other site 630626002184 ATP binding site [chemical binding]; other site 630626002185 Q-loop/lid; other site 630626002186 ABC transporter signature motif; other site 630626002187 Walker B; other site 630626002188 D-loop; other site 630626002189 H-loop/switch region; other site 630626002190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626002191 dimerization interface [polypeptide binding]; other site 630626002192 putative DNA binding site [nucleotide binding]; other site 630626002193 putative Zn2+ binding site [ion binding]; other site 630626002194 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 630626002195 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 630626002196 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 630626002197 P loop; other site 630626002198 Nucleotide binding site [chemical binding]; other site 630626002199 DTAP/Switch II; other site 630626002200 Switch I; other site 630626002201 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 630626002202 P loop; other site 630626002203 Nucleotide binding site [chemical binding]; other site 630626002204 DTAP/Switch II; other site 630626002205 Switch I; other site 630626002206 arsenical pump membrane protein; Provisional; Region: PRK15445 630626002207 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 630626002208 transmembrane helices; other site 630626002209 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 630626002210 ArsC family; Region: ArsC; pfam03960 630626002211 catalytic residues [active] 630626002212 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 630626002213 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 630626002214 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 630626002215 Propanediol utilisation protein PduL; Region: PduL; pfam06130 630626002216 Propanediol utilisation protein PduL; Region: PduL; pfam06130 630626002217 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 630626002218 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 630626002219 Hexamer interface [polypeptide binding]; other site 630626002220 Hexagonal pore residue; other site 630626002221 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 630626002222 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626002223 Pyruvate formate lyase; Region: PFL; pfam02901 630626002224 Pyruvate formate lyase; Region: PFL; pfam02901 630626002225 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 630626002226 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 630626002227 dimer interface [polypeptide binding]; other site 630626002228 active site 630626002229 glycine loop; other site 630626002230 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 630626002231 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 630626002232 putative active site [active] 630626002233 metal binding site [ion binding]; metal-binding site 630626002234 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 630626002235 Hexamer/Pentamer interface [polypeptide binding]; other site 630626002236 central pore; other site 630626002237 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 630626002238 putative catalytic cysteine [active] 630626002239 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 630626002240 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 630626002241 Hexamer interface [polypeptide binding]; other site 630626002242 Hexagonal pore residue; other site 630626002243 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 630626002244 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 630626002245 Hexamer interface [polypeptide binding]; other site 630626002246 Hexagonal pore residue; other site 630626002247 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 630626002248 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 630626002249 Hexamer interface [polypeptide binding]; other site 630626002250 Hexagonal pore residue; other site 630626002251 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 630626002252 DNA binding site [nucleotide binding] 630626002253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626002254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626002255 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 630626002256 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626002257 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 630626002258 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 630626002259 FAD binding pocket [chemical binding]; other site 630626002260 FAD binding motif [chemical binding]; other site 630626002261 phosphate binding motif [ion binding]; other site 630626002262 beta-alpha-beta structure motif; other site 630626002263 NAD binding pocket [chemical binding]; other site 630626002264 Iron coordination center [ion binding]; other site 630626002265 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 630626002266 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 630626002267 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626002268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 630626002269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 630626002270 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 630626002271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626002272 putative Zn2+ binding site [ion binding]; other site 630626002273 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 630626002274 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 630626002275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 630626002276 DHHA2 domain; Region: DHHA2; pfam02833 630626002277 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 630626002278 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 630626002279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626002280 active site 630626002281 phosphorylation site [posttranslational modification] 630626002282 intermolecular recognition site; other site 630626002283 dimerization interface [polypeptide binding]; other site 630626002284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626002285 DNA binding site [nucleotide binding] 630626002286 sensor protein QseC; Provisional; Region: PRK10337 630626002287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626002288 dimer interface [polypeptide binding]; other site 630626002289 phosphorylation site [posttranslational modification] 630626002290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626002291 ATP binding site [chemical binding]; other site 630626002292 Mg2+ binding site [ion binding]; other site 630626002293 G-X-G motif; other site 630626002294 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 630626002295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626002296 DNA-binding site [nucleotide binding]; DNA binding site 630626002297 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626002298 D-mannonate oxidoreductase; Provisional; Region: PRK15037 630626002299 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 630626002300 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 630626002301 mannonate dehydratase; Provisional; Region: PRK03906 630626002302 mannonate dehydratase; Region: uxuA; TIGR00695 630626002303 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626002304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626002305 DNA binding site [nucleotide binding] 630626002306 domain linker motif; other site 630626002307 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 630626002308 dimerization interface (closed form) [polypeptide binding]; other site 630626002309 ligand binding site [chemical binding]; other site 630626002310 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 630626002311 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 630626002312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626002313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626002314 homodimer interface [polypeptide binding]; other site 630626002315 catalytic residue [active] 630626002316 Creatinine amidohydrolase; Region: Creatininase; pfam02633 630626002317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626002318 DNA-binding site [nucleotide binding]; DNA binding site 630626002319 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 630626002320 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 630626002321 Na binding site [ion binding]; other site 630626002322 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 630626002323 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 630626002324 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626002325 N-terminal plug; other site 630626002326 ligand-binding site [chemical binding]; other site 630626002327 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 630626002328 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 630626002329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626002330 dimer interface [polypeptide binding]; other site 630626002331 conserved gate region; other site 630626002332 putative PBP binding loops; other site 630626002333 ABC-ATPase subunit interface; other site 630626002334 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 630626002335 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 630626002336 Walker A/P-loop; other site 630626002337 ATP binding site [chemical binding]; other site 630626002338 Q-loop/lid; other site 630626002339 ABC transporter signature motif; other site 630626002340 Walker B; other site 630626002341 D-loop; other site 630626002342 H-loop/switch region; other site 630626002343 NIL domain; Region: NIL; pfam09383 630626002344 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 630626002345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626002346 DNA binding residues [nucleotide binding] 630626002347 dimerization interface [polypeptide binding]; other site 630626002348 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 630626002349 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 630626002350 putative Cl- selectivity filter; other site 630626002351 putative pore gating glutamate residue; other site 630626002352 putative acyltransferase; Provisional; Region: PRK05790 630626002353 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626002354 dimer interface [polypeptide binding]; other site 630626002355 active site 630626002356 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 630626002357 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 630626002358 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 630626002359 NADP binding site [chemical binding]; other site 630626002360 homodimer interface [polypeptide binding]; other site 630626002361 active site 630626002362 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 630626002363 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 630626002364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626002365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626002366 dimerization interface [polypeptide binding]; other site 630626002367 diaminopimelate decarboxylase; Provisional; Region: PRK11165 630626002368 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 630626002369 active site 630626002370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626002371 substrate binding site [chemical binding]; other site 630626002372 catalytic residues [active] 630626002373 dimer interface [polypeptide binding]; other site 630626002374 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 630626002375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626002376 DNA binding site [nucleotide binding] 630626002377 domain linker motif; other site 630626002378 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 630626002379 dimerization interface (closed form) [polypeptide binding]; other site 630626002380 ligand binding site [chemical binding]; other site 630626002381 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 630626002382 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 630626002383 putative acyl-acceptor binding pocket; other site 630626002384 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 630626002385 acyl-activating enzyme (AAE) consensus motif; other site 630626002386 putative AMP binding site [chemical binding]; other site 630626002387 lysophospholipid transporter LplT; Provisional; Region: PRK11195 630626002388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002389 putative substrate translocation pore; other site 630626002390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 630626002391 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 630626002392 active site 630626002393 catalytic tetrad [active] 630626002394 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 630626002395 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 630626002396 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 630626002397 putative DNA-binding cleft [nucleotide binding]; other site 630626002398 putative DNA clevage site; other site 630626002399 molecular lever; other site 630626002400 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 630626002401 putative active site [active] 630626002402 Ap4A binding site [chemical binding]; other site 630626002403 nudix motif; other site 630626002404 putative metal binding site [ion binding]; other site 630626002405 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 630626002406 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 630626002407 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 630626002408 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 630626002409 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 630626002410 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 630626002411 thymidylate synthase; Reviewed; Region: thyA; PRK01827 630626002412 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 630626002413 dimerization interface [polypeptide binding]; other site 630626002414 active site 630626002415 hypothetical protein; Provisional; Region: PRK10506 630626002416 hypothetical protein; Provisional; Region: PRK10557 630626002417 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 630626002418 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 630626002419 hypothetical protein; Provisional; Region: PRK10332 630626002420 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 630626002421 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 630626002422 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 630626002423 protease3; Provisional; Region: PRK15101 630626002424 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 630626002425 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 630626002426 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 630626002427 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 630626002428 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 630626002429 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 630626002430 AAA domain; Region: AAA_30; pfam13604 630626002431 Family description; Region: UvrD_C_2; pfam13538 630626002432 N-acetylglutamate synthase; Validated; Region: PRK05279 630626002433 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 630626002434 putative feedback inhibition sensing region; other site 630626002435 putative nucleotide binding site [chemical binding]; other site 630626002436 putative substrate binding site [chemical binding]; other site 630626002437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626002438 Coenzyme A binding pocket [chemical binding]; other site 630626002439 AMIN domain; Region: AMIN; pfam11741 630626002440 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 630626002441 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 630626002442 active site 630626002443 metal binding site [ion binding]; metal-binding site 630626002444 murein transglycosylase A; Provisional; Region: mltA; PRK11162 630626002445 MltA specific insert domain; Region: MltA; pfam03562 630626002446 3D domain; Region: 3D; pfam06725 630626002447 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 630626002448 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 630626002449 putative ATP binding site [chemical binding]; other site 630626002450 putative substrate interface [chemical binding]; other site 630626002451 Fe-S metabolism associated domain; Region: SufE; cl00951 630626002452 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 630626002453 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 630626002454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626002455 catalytic residue [active] 630626002456 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 630626002457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626002458 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 630626002459 dimerization interface [polypeptide binding]; other site 630626002460 substrate binding pocket [chemical binding]; other site 630626002461 hypothetical protein; Provisional; Region: PRK10873 630626002462 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 630626002463 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 630626002464 flap endonuclease-like protein; Provisional; Region: PRK09482 630626002465 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 630626002466 active site 630626002467 metal binding site 1 [ion binding]; metal-binding site 630626002468 putative 5' ssDNA interaction site; other site 630626002469 metal binding site 3; metal-binding site 630626002470 metal binding site 2 [ion binding]; metal-binding site 630626002471 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 630626002472 putative DNA binding site [nucleotide binding]; other site 630626002473 putative metal binding site [ion binding]; other site 630626002474 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 630626002475 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 630626002476 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 630626002477 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626002478 serine transporter; Region: stp; TIGR00814 630626002479 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 630626002480 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 630626002481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 630626002482 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 630626002483 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 630626002484 SecY interacting protein Syd; Provisional; Region: PRK04968 630626002485 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 630626002486 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 630626002487 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 630626002488 probable active site [active] 630626002489 flavodoxin; Provisional; Region: PRK08105 630626002490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002491 D-galactonate transporter; Region: 2A0114; TIGR00893 630626002492 putative substrate translocation pore; other site 630626002493 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 630626002494 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 630626002495 active site 630626002496 tetramer interface [polypeptide binding]; other site 630626002497 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 630626002498 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 630626002499 active site 630626002500 tetramer interface [polypeptide binding]; other site 630626002501 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 630626002502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626002503 non-specific DNA binding site [nucleotide binding]; other site 630626002504 salt bridge; other site 630626002505 sequence-specific DNA binding site [nucleotide binding]; other site 630626002506 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 630626002507 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 630626002508 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 630626002509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626002510 dimerization interface [polypeptide binding]; other site 630626002511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626002512 dimer interface [polypeptide binding]; other site 630626002513 phosphorylation site [posttranslational modification] 630626002514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626002515 ATP binding site [chemical binding]; other site 630626002516 Mg2+ binding site [ion binding]; other site 630626002517 G-X-G motif; other site 630626002518 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 630626002519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626002520 active site 630626002521 phosphorylation site [posttranslational modification] 630626002522 intermolecular recognition site; other site 630626002523 dimerization interface [polypeptide binding]; other site 630626002524 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 630626002525 putative binding surface; other site 630626002526 active site 630626002527 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 630626002528 TRAM domain; Region: TRAM; pfam01938 630626002529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626002530 S-adenosylmethionine binding site [chemical binding]; other site 630626002531 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 630626002532 HD domain; Region: HD_4; pfam13328 630626002533 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 630626002534 synthetase active site [active] 630626002535 NTP binding site [chemical binding]; other site 630626002536 metal binding site [ion binding]; metal-binding site 630626002537 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 630626002538 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 630626002539 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 630626002540 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 630626002541 homodimer interface [polypeptide binding]; other site 630626002542 metal binding site [ion binding]; metal-binding site 630626002543 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 630626002544 homodimer interface [polypeptide binding]; other site 630626002545 active site 630626002546 putative chemical substrate binding site [chemical binding]; other site 630626002547 metal binding site [ion binding]; metal-binding site 630626002548 CTP synthetase; Validated; Region: pyrG; PRK05380 630626002549 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 630626002550 Catalytic site [active] 630626002551 active site 630626002552 UTP binding site [chemical binding]; other site 630626002553 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 630626002554 active site 630626002555 putative oxyanion hole; other site 630626002556 catalytic triad [active] 630626002557 enolase; Provisional; Region: eno; PRK00077 630626002558 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 630626002559 dimer interface [polypeptide binding]; other site 630626002560 metal binding site [ion binding]; metal-binding site 630626002561 substrate binding pocket [chemical binding]; other site 630626002562 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 630626002563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 630626002564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626002565 dimer interface [polypeptide binding]; other site 630626002566 phosphorylation site [posttranslational modification] 630626002567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626002568 ATP binding site [chemical binding]; other site 630626002569 Mg2+ binding site [ion binding]; other site 630626002570 G-X-G motif; other site 630626002571 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 630626002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626002573 active site 630626002574 phosphorylation site [posttranslational modification] 630626002575 intermolecular recognition site; other site 630626002576 dimerization interface [polypeptide binding]; other site 630626002577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626002578 DNA binding residues [nucleotide binding] 630626002579 dimerization interface [polypeptide binding]; other site 630626002580 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 630626002581 4Fe-4S binding domain; Region: Fer4; cl02805 630626002582 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 630626002583 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 630626002584 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626002585 molybdopterin cofactor binding site; other site 630626002586 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 630626002587 putative molybdopterin cofactor binding site; other site 630626002588 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 630626002589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 630626002590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626002591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626002592 putative active site [active] 630626002593 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 630626002594 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 630626002595 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 630626002596 active site turn [active] 630626002597 phosphorylation site [posttranslational modification] 630626002598 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 630626002599 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 630626002600 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 630626002601 active site 630626002602 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 630626002603 Flavodoxin; Region: Flavodoxin_1; pfam00258 630626002604 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 630626002605 FAD binding pocket [chemical binding]; other site 630626002606 FAD binding motif [chemical binding]; other site 630626002607 catalytic residues [active] 630626002608 NAD binding pocket [chemical binding]; other site 630626002609 phosphate binding motif [ion binding]; other site 630626002610 beta-alpha-beta structure motif; other site 630626002611 sulfite reductase subunit beta; Provisional; Region: PRK13504 630626002612 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 630626002613 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 630626002614 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 630626002615 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 630626002616 Active Sites [active] 630626002617 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 630626002618 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 630626002619 metal binding site [ion binding]; metal-binding site 630626002620 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 630626002621 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 630626002622 Active Sites [active] 630626002623 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 630626002624 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 630626002625 CysD dimerization site [polypeptide binding]; other site 630626002626 G1 box; other site 630626002627 putative GEF interaction site [polypeptide binding]; other site 630626002628 GTP/Mg2+ binding site [chemical binding]; other site 630626002629 Switch I region; other site 630626002630 G2 box; other site 630626002631 G3 box; other site 630626002632 Switch II region; other site 630626002633 G4 box; other site 630626002634 G5 box; other site 630626002635 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 630626002636 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 630626002637 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 630626002638 ligand-binding site [chemical binding]; other site 630626002639 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 630626002640 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 630626002641 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 630626002642 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 630626002643 substrate binding site; other site 630626002644 dimer interface; other site 630626002645 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 630626002646 homotrimer interaction site [polypeptide binding]; other site 630626002647 zinc binding site [ion binding]; other site 630626002648 CDP-binding sites; other site 630626002649 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 630626002650 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 630626002651 Permutation of conserved domain; other site 630626002652 active site 630626002653 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 630626002654 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 630626002655 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 630626002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626002657 S-adenosylmethionine binding site [chemical binding]; other site 630626002658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 630626002659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626002660 Peptidase family M23; Region: Peptidase_M23; pfam01551 630626002661 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 630626002662 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 630626002663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 630626002664 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 630626002665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 630626002666 DNA binding residues [nucleotide binding] 630626002667 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 630626002668 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 630626002669 MutS domain I; Region: MutS_I; pfam01624 630626002670 MutS domain II; Region: MutS_II; pfam05188 630626002671 MutS domain III; Region: MutS_III; pfam05192 630626002672 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 630626002673 Walker A/P-loop; other site 630626002674 ATP binding site [chemical binding]; other site 630626002675 Q-loop/lid; other site 630626002676 ABC transporter signature motif; other site 630626002677 Walker B; other site 630626002678 D-loop; other site 630626002679 H-loop/switch region; other site 630626002680 Transposase; Region: HTH_Tnp_1; cl17663 630626002681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626002682 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 630626002683 HTH-like domain; Region: HTH_21; pfam13276 630626002684 Integrase core domain; Region: rve; pfam00665 630626002685 Integrase core domain; Region: rve_3; pfam13683 630626002686 Fic/DOC family; Region: Fic; pfam02661 630626002687 putative transposase OrfB; Reviewed; Region: PHA02517 630626002688 HTH-like domain; Region: HTH_21; pfam13276 630626002689 Integrase core domain; Region: rve; pfam00665 630626002690 Integrase core domain; Region: rve_3; pfam13683 630626002691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626002692 Transposase; Region: HTH_Tnp_1; cl17663 630626002693 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 630626002694 catalytic core [active] 630626002695 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 630626002696 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 630626002697 Walker A/P-loop; other site 630626002698 ATP binding site [chemical binding]; other site 630626002699 Q-loop/lid; other site 630626002700 ABC transporter signature motif; other site 630626002701 Walker B; other site 630626002702 D-loop; other site 630626002703 H-loop/switch region; other site 630626002704 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 630626002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626002706 dimer interface [polypeptide binding]; other site 630626002707 conserved gate region; other site 630626002708 putative PBP binding loops; other site 630626002709 ABC-ATPase subunit interface; other site 630626002710 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 630626002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626002712 dimer interface [polypeptide binding]; other site 630626002713 conserved gate region; other site 630626002714 putative PBP binding loops; other site 630626002715 ABC-ATPase subunit interface; other site 630626002716 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 630626002717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626002718 membrane-bound complex binding site; other site 630626002719 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 630626002720 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 630626002721 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 630626002722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626002723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626002724 catalytic residue [active] 630626002725 hypothetical protein; Validated; Region: PRK03661 630626002726 recombinase A; Provisional; Region: recA; PRK09354 630626002727 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 630626002728 hexamer interface [polypeptide binding]; other site 630626002729 Walker A motif; other site 630626002730 ATP binding site [chemical binding]; other site 630626002731 Walker B motif; other site 630626002732 recombination regulator RecX; Reviewed; Region: recX; PRK00117 630626002733 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 630626002734 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 630626002735 motif 1; other site 630626002736 active site 630626002737 motif 2; other site 630626002738 motif 3; other site 630626002739 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 630626002740 DHHA1 domain; Region: DHHA1; pfam02272 630626002741 carbon storage regulator; Provisional; Region: PRK01712 630626002742 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 630626002743 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 630626002744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626002745 motif II; other site 630626002746 Predicted membrane protein [Function unknown]; Region: COG1238 630626002747 glutamate--cysteine ligase; Provisional; Region: PRK02107 630626002748 S-ribosylhomocysteinase; Provisional; Region: PRK02260 630626002749 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 630626002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002751 putative substrate translocation pore; other site 630626002752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002753 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 630626002754 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626002755 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626002756 transcriptional repressor MprA; Provisional; Region: PRK10870 630626002757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626002758 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 630626002759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002760 putative substrate translocation pore; other site 630626002761 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 630626002762 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 630626002763 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 630626002764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626002765 dimer interface [polypeptide binding]; other site 630626002766 conserved gate region; other site 630626002767 putative PBP binding loops; other site 630626002768 ABC-ATPase subunit interface; other site 630626002769 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 630626002770 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 630626002771 Walker A/P-loop; other site 630626002772 ATP binding site [chemical binding]; other site 630626002773 Q-loop/lid; other site 630626002774 ABC transporter signature motif; other site 630626002775 Walker B; other site 630626002776 D-loop; other site 630626002777 H-loop/switch region; other site 630626002778 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 630626002779 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 630626002780 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 630626002781 dimer interface [polypeptide binding]; other site 630626002782 putative radical transfer pathway; other site 630626002783 diiron center [ion binding]; other site 630626002784 tyrosyl radical; other site 630626002785 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 630626002786 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 630626002787 Class I ribonucleotide reductase; Region: RNR_I; cd01679 630626002788 active site 630626002789 dimer interface [polypeptide binding]; other site 630626002790 catalytic residues [active] 630626002791 effector binding site; other site 630626002792 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 630626002793 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 630626002794 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 630626002795 catalytic residues [active] 630626002796 hypothetical protein; Provisional; Region: PRK10556 630626002797 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 630626002798 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 630626002799 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 630626002800 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 630626002801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626002802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626002803 dimerization interface [polypeptide binding]; other site 630626002804 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 630626002805 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 630626002806 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 630626002807 CoA binding domain; Region: CoA_binding; cl17356 630626002808 CoA-ligase; Region: Ligase_CoA; pfam00549 630626002809 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 630626002810 carbamate kinase; Reviewed; Region: PRK12686 630626002811 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 630626002812 putative substrate binding site [chemical binding]; other site 630626002813 nucleotide binding site [chemical binding]; other site 630626002814 nucleotide binding site [chemical binding]; other site 630626002815 homodimer interface [polypeptide binding]; other site 630626002816 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 630626002817 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 630626002818 heme binding site [chemical binding]; other site 630626002819 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 630626002820 heme binding site [chemical binding]; other site 630626002821 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 630626002822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 630626002823 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 630626002824 active site residue [active] 630626002825 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 630626002826 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 630626002827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 630626002828 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 630626002829 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 630626002830 active site 630626002831 metal binding site [ion binding]; metal-binding site 630626002832 D5 N terminal like; Region: D5_N; smart00885 630626002833 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 630626002834 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 630626002835 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 630626002836 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 630626002837 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 630626002838 AAA domain; Region: AAA_21; pfam13304 630626002839 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 630626002840 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 630626002841 putative active site [active] 630626002842 putative metal-binding site [ion binding]; other site 630626002843 integrase; Provisional; Region: PRK09692 630626002844 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 630626002845 active site 630626002846 Int/Topo IB signature motif; other site 630626002847 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 630626002848 SmpB-tmRNA interface; other site 630626002849 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 630626002850 putative coenzyme Q binding site [chemical binding]; other site 630626002851 hypothetical protein; Validated; Region: PRK01777 630626002852 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 630626002853 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 630626002854 recombination and repair protein; Provisional; Region: PRK10869 630626002855 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 630626002856 Walker A/P-loop; other site 630626002857 ATP binding site [chemical binding]; other site 630626002858 Q-loop/lid; other site 630626002859 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 630626002860 ABC transporter signature motif; other site 630626002861 Walker B; other site 630626002862 D-loop; other site 630626002863 H-loop/switch region; other site 630626002864 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 630626002865 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 630626002866 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 630626002867 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 630626002868 dimer interface [polypeptide binding]; other site 630626002869 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 630626002870 hypothetical protein; Provisional; Region: PRK11573 630626002871 Domain of unknown function DUF21; Region: DUF21; pfam01595 630626002872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 630626002873 Transporter associated domain; Region: CorC_HlyC; smart01091 630626002874 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 630626002875 signal recognition particle protein; Provisional; Region: PRK10867 630626002876 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 630626002877 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 630626002878 P loop; other site 630626002879 GTP binding site [chemical binding]; other site 630626002880 Signal peptide binding domain; Region: SRP_SPB; pfam02978 630626002881 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 630626002882 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 630626002883 RimM N-terminal domain; Region: RimM; pfam01782 630626002884 PRC-barrel domain; Region: PRC; pfam05239 630626002885 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 630626002886 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 630626002887 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 630626002888 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 630626002889 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 630626002890 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 630626002891 haemagglutination activity domain; Region: Haemagg_act; pfam05860 630626002892 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 630626002893 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626002894 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626002895 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626002896 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 630626002897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 630626002898 ligand binding site [chemical binding]; other site 630626002899 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 630626002900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626002901 metal binding site [ion binding]; metal-binding site 630626002902 active site 630626002903 I-site; other site 630626002904 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 630626002905 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 630626002906 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 630626002907 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 630626002908 Chorismate mutase type II; Region: CM_2; cl00693 630626002909 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 630626002910 prephenate dehydrogenase; Validated; Region: PRK08507 630626002911 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 630626002912 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 630626002913 Prephenate dehydratase; Region: PDT; pfam00800 630626002914 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 630626002915 putative L-Phe binding site [chemical binding]; other site 630626002916 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 630626002917 30S subunit binding site; other site 630626002918 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 630626002919 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 630626002920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626002921 RNA binding surface [nucleotide binding]; other site 630626002922 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 630626002923 active site 630626002924 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 630626002925 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 630626002926 protein disaggregation chaperone; Provisional; Region: PRK10865 630626002927 Clp amino terminal domain; Region: Clp_N; pfam02861 630626002928 Clp amino terminal domain; Region: Clp_N; pfam02861 630626002929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626002930 Walker A motif; other site 630626002931 ATP binding site [chemical binding]; other site 630626002932 Walker B motif; other site 630626002933 arginine finger; other site 630626002934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626002935 Walker A motif; other site 630626002936 ATP binding site [chemical binding]; other site 630626002937 Walker B motif; other site 630626002938 arginine finger; other site 630626002939 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 630626002940 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 630626002941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626002942 putative substrate translocation pore; other site 630626002943 lipoprotein; Provisional; Region: PRK10759 630626002944 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 630626002945 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 630626002946 domain interface [polypeptide binding]; other site 630626002947 putative active site [active] 630626002948 catalytic site [active] 630626002949 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 630626002950 domain interface [polypeptide binding]; other site 630626002951 putative active site [active] 630626002952 catalytic site [active] 630626002953 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 630626002954 CoA binding domain; Region: CoA_binding_2; pfam13380 630626002955 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 630626002956 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 630626002957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 630626002958 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 630626002959 Uncharacterized conserved protein [Function unknown]; Region: COG3148 630626002960 thioredoxin 2; Provisional; Region: PRK10996 630626002961 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 630626002962 catalytic residues [active] 630626002963 putative methyltransferase; Provisional; Region: PRK10864 630626002964 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 630626002965 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 630626002966 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 630626002967 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 630626002968 acyl-activating enzyme (AAE) consensus motif; other site 630626002969 AMP binding site [chemical binding]; other site 630626002970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 630626002971 thioester reductase domain; Region: Thioester-redct; TIGR01746 630626002972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626002973 NAD(P) binding site [chemical binding]; other site 630626002974 active site 630626002975 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 630626002976 ligand binding site [chemical binding]; other site 630626002977 active site 630626002978 UGI interface [polypeptide binding]; other site 630626002979 catalytic site [active] 630626002980 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 630626002981 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 630626002982 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 630626002983 ATP binding site [chemical binding]; other site 630626002984 Mg++ binding site [ion binding]; other site 630626002985 motif III; other site 630626002986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626002987 nucleotide binding region [chemical binding]; other site 630626002988 ATP-binding site [chemical binding]; other site 630626002989 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 630626002990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626002991 S-adenosylmethionine binding site [chemical binding]; other site 630626002992 L-aspartate oxidase; Provisional; Region: PRK09077 630626002993 L-aspartate oxidase; Provisional; Region: PRK06175 630626002994 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 630626002995 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 630626002996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 630626002997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 630626002998 DNA binding residues [nucleotide binding] 630626002999 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 630626003000 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 630626003001 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 630626003002 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 630626003003 anti-sigma E factor; Provisional; Region: rseB; PRK09455 630626003004 SoxR reducing system protein RseC; Provisional; Region: PRK10862 630626003005 GTP-binding protein LepA; Provisional; Region: PRK05433 630626003006 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 630626003007 G1 box; other site 630626003008 putative GEF interaction site [polypeptide binding]; other site 630626003009 GTP/Mg2+ binding site [chemical binding]; other site 630626003010 Switch I region; other site 630626003011 G2 box; other site 630626003012 G3 box; other site 630626003013 Switch II region; other site 630626003014 G4 box; other site 630626003015 G5 box; other site 630626003016 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 630626003017 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 630626003018 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 630626003019 signal peptidase I; Provisional; Region: PRK10861 630626003020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 630626003021 Catalytic site [active] 630626003022 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 630626003023 ribonuclease III; Reviewed; Region: rnc; PRK00102 630626003024 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 630626003025 dimerization interface [polypeptide binding]; other site 630626003026 active site 630626003027 metal binding site [ion binding]; metal-binding site 630626003028 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 630626003029 dsRNA binding site [nucleotide binding]; other site 630626003030 GTPase Era; Reviewed; Region: era; PRK00089 630626003031 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 630626003032 G1 box; other site 630626003033 GTP/Mg2+ binding site [chemical binding]; other site 630626003034 Switch I region; other site 630626003035 G2 box; other site 630626003036 Switch II region; other site 630626003037 G3 box; other site 630626003038 G4 box; other site 630626003039 G5 box; other site 630626003040 KH domain; Region: KH_2; pfam07650 630626003041 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 630626003042 Recombination protein O N terminal; Region: RecO_N; pfam11967 630626003043 Recombination protein O C terminal; Region: RecO_C; pfam02565 630626003044 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 630626003045 active site 630626003046 hydrophilic channel; other site 630626003047 dimerization interface [polypeptide binding]; other site 630626003048 catalytic residues [active] 630626003049 active site lid [active] 630626003050 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 630626003051 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 630626003052 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626003053 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 630626003054 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626003055 putative active site [active] 630626003056 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 630626003057 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 630626003058 putative active site [active] 630626003059 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 630626003060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 630626003061 active site turn [active] 630626003062 phosphorylation site [posttranslational modification] 630626003063 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 630626003064 hypothetical protein; Provisional; Region: PRK11590 630626003065 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 630626003066 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 630626003067 nucleoside/Zn binding site; other site 630626003068 dimer interface [polypeptide binding]; other site 630626003069 catalytic motif [active] 630626003070 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 630626003071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626003072 substrate binding pocket [chemical binding]; other site 630626003073 membrane-bound complex binding site; other site 630626003074 hinge residues; other site 630626003075 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626003076 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626003077 catalytic residue [active] 630626003078 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 630626003079 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 630626003080 dimerization interface [polypeptide binding]; other site 630626003081 ATP binding site [chemical binding]; other site 630626003082 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 630626003083 dimerization interface [polypeptide binding]; other site 630626003084 ATP binding site [chemical binding]; other site 630626003085 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 630626003086 putative active site [active] 630626003087 catalytic triad [active] 630626003088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 630626003089 HAMP domain; Region: HAMP; pfam00672 630626003090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626003091 dimer interface [polypeptide binding]; other site 630626003092 phosphorylation site [posttranslational modification] 630626003093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626003094 ATP binding site [chemical binding]; other site 630626003095 Mg2+ binding site [ion binding]; other site 630626003096 G-X-G motif; other site 630626003097 hypothetical protein; Provisional; Region: PRK10722 630626003098 response regulator GlrR; Provisional; Region: PRK15115 630626003099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003100 active site 630626003101 phosphorylation site [posttranslational modification] 630626003102 intermolecular recognition site; other site 630626003103 dimerization interface [polypeptide binding]; other site 630626003104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626003105 Walker A motif; other site 630626003106 ATP binding site [chemical binding]; other site 630626003107 Walker B motif; other site 630626003108 arginine finger; other site 630626003109 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 630626003110 Nitrogen regulatory protein P-II; Region: P-II; smart00938 630626003111 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 630626003112 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 630626003113 heme-binding site [chemical binding]; other site 630626003114 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 630626003115 FAD binding pocket [chemical binding]; other site 630626003116 FAD binding motif [chemical binding]; other site 630626003117 phosphate binding motif [ion binding]; other site 630626003118 beta-alpha-beta structure motif; other site 630626003119 NAD binding pocket [chemical binding]; other site 630626003120 Heme binding pocket [chemical binding]; other site 630626003121 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 630626003122 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 630626003123 dimer interface [polypeptide binding]; other site 630626003124 active site 630626003125 glycine-pyridoxal phosphate binding site [chemical binding]; other site 630626003126 folate binding site [chemical binding]; other site 630626003127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 630626003128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003129 active site 630626003130 phosphorylation site [posttranslational modification] 630626003131 intermolecular recognition site; other site 630626003132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626003133 DNA binding residues [nucleotide binding] 630626003134 dimerization interface [polypeptide binding]; other site 630626003135 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 630626003136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003137 active site 630626003138 phosphorylation site [posttranslational modification] 630626003139 intermolecular recognition site; other site 630626003140 dimerization interface [polypeptide binding]; other site 630626003141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626003142 DNA binding residues [nucleotide binding] 630626003143 dimerization interface [polypeptide binding]; other site 630626003144 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 630626003145 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 630626003146 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 630626003147 PRD domain; Region: PRD; pfam00874 630626003148 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 630626003149 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 630626003150 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 630626003151 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 630626003152 active site 630626003153 dimerization interface [polypeptide binding]; other site 630626003154 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 630626003155 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 630626003156 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 630626003157 Rrf2 family protein; Region: rrf2_super; TIGR00738 630626003158 cysteine desulfurase; Provisional; Region: PRK14012 630626003159 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 630626003160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626003161 catalytic residue [active] 630626003162 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 630626003163 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 630626003164 trimerization site [polypeptide binding]; other site 630626003165 active site 630626003166 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 630626003167 co-chaperone HscB; Provisional; Region: hscB; PRK05014 630626003168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 630626003169 HSP70 interaction site [polypeptide binding]; other site 630626003170 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 630626003171 chaperone protein HscA; Provisional; Region: hscA; PRK05183 630626003172 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 630626003173 nucleotide binding site [chemical binding]; other site 630626003174 putative NEF/HSP70 interaction site [polypeptide binding]; other site 630626003175 SBD interface [polypeptide binding]; other site 630626003176 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 630626003177 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626003178 catalytic loop [active] 630626003179 iron binding site [ion binding]; other site 630626003180 hypothetical protein; Provisional; Region: PRK10721 630626003181 aminopeptidase B; Provisional; Region: PRK05015 630626003182 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 630626003183 interface (dimer of trimers) [polypeptide binding]; other site 630626003184 Substrate-binding/catalytic site; other site 630626003185 Zn-binding sites [ion binding]; other site 630626003186 SseB protein; Region: SseB; cl06279 630626003187 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 630626003188 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 630626003189 active site residue [active] 630626003190 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 630626003191 active site residue [active] 630626003192 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 630626003193 active site 630626003194 multimer interface [polypeptide binding]; other site 630626003195 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 630626003196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626003197 FeS/SAM binding site; other site 630626003198 cytoskeletal protein RodZ; Provisional; Region: PRK10856 630626003199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626003200 non-specific DNA binding site [nucleotide binding]; other site 630626003201 salt bridge; other site 630626003202 sequence-specific DNA binding site [nucleotide binding]; other site 630626003203 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 630626003204 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 630626003205 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 630626003206 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 630626003207 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 630626003208 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 630626003209 dimer interface [polypeptide binding]; other site 630626003210 motif 1; other site 630626003211 active site 630626003212 motif 2; other site 630626003213 motif 3; other site 630626003214 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 630626003215 anticodon binding site; other site 630626003216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 630626003217 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 630626003218 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 630626003219 Trp docking motif [polypeptide binding]; other site 630626003220 GTP-binding protein Der; Reviewed; Region: PRK00093 630626003221 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 630626003222 G1 box; other site 630626003223 GTP/Mg2+ binding site [chemical binding]; other site 630626003224 Switch I region; other site 630626003225 G2 box; other site 630626003226 Switch II region; other site 630626003227 G3 box; other site 630626003228 G4 box; other site 630626003229 G5 box; other site 630626003230 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 630626003231 G1 box; other site 630626003232 GTP/Mg2+ binding site [chemical binding]; other site 630626003233 Switch I region; other site 630626003234 G2 box; other site 630626003235 G3 box; other site 630626003236 Switch II region; other site 630626003237 G4 box; other site 630626003238 G5 box; other site 630626003239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626003240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626003241 metal binding site [ion binding]; metal-binding site 630626003242 active site 630626003243 I-site; other site 630626003244 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 630626003245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626003246 NAD(P) binding site [chemical binding]; other site 630626003247 active site 630626003248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626003249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626003250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 630626003251 dimerization interface [polypeptide binding]; other site 630626003252 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 630626003253 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 630626003254 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 630626003255 generic binding surface II; other site 630626003256 generic binding surface I; other site 630626003257 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 630626003258 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 630626003259 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 630626003260 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 630626003261 active site 630626003262 GMP synthase; Reviewed; Region: guaA; PRK00074 630626003263 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 630626003264 AMP/PPi binding site [chemical binding]; other site 630626003265 candidate oxyanion hole; other site 630626003266 catalytic triad [active] 630626003267 potential glutamine specificity residues [chemical binding]; other site 630626003268 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 630626003269 ATP Binding subdomain [chemical binding]; other site 630626003270 Ligand Binding sites [chemical binding]; other site 630626003271 Dimerization subdomain; other site 630626003272 Protein of unknown function DUF262; Region: DUF262; pfam03235 630626003273 Uncharacterized conserved protein [Function unknown]; Region: COG1479 630626003274 Uncharacterized conserved protein [Function unknown]; Region: COG1479 630626003275 Protein of unknown function DUF262; Region: DUF262; pfam03235 630626003276 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 630626003277 MASE1; Region: MASE1; pfam05231 630626003278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626003279 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 630626003280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626003281 exopolyphosphatase; Provisional; Region: PRK10854 630626003282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626003283 nucleotide binding site [chemical binding]; other site 630626003284 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 630626003285 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 630626003286 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 630626003287 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 630626003288 domain interface [polypeptide binding]; other site 630626003289 active site 630626003290 catalytic site [active] 630626003291 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 630626003292 domain interface [polypeptide binding]; other site 630626003293 active site 630626003294 catalytic site [active] 630626003295 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 630626003296 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 630626003297 active site 630626003298 substrate binding site [chemical binding]; other site 630626003299 cosubstrate binding site; other site 630626003300 catalytic site [active] 630626003301 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 630626003302 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 630626003303 dimerization interface [polypeptide binding]; other site 630626003304 putative ATP binding site [chemical binding]; other site 630626003305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626003306 active site 630626003307 uracil transporter; Provisional; Region: PRK10720 630626003308 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 630626003309 DNA replication initiation factor; Provisional; Region: PRK08084 630626003310 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 630626003311 ArsC family; Region: ArsC; pfam03960 630626003312 catalytic residues [active] 630626003313 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 630626003314 Peptidase family M48; Region: Peptidase_M48; cl12018 630626003315 Domain of unknown function DUF20; Region: UPF0118; pfam01594 630626003316 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 630626003317 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 630626003318 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 630626003319 catalytic triad [active] 630626003320 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 630626003321 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 630626003322 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 630626003323 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 630626003324 dihydrodipicolinate synthase; Region: dapA; TIGR00674 630626003325 dimer interface [polypeptide binding]; other site 630626003326 active site 630626003327 catalytic residue [active] 630626003328 lipoprotein; Provisional; Region: PRK11679 630626003329 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 630626003330 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 630626003331 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 630626003332 ATP binding site [chemical binding]; other site 630626003333 active site 630626003334 substrate binding site [chemical binding]; other site 630626003335 Predicted metalloprotease [General function prediction only]; Region: COG2321 630626003336 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 630626003337 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 630626003338 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 630626003339 Helicase; Region: Helicase_RecD; pfam05127 630626003340 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 630626003341 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 630626003342 putative hydrolase; Provisional; Region: PRK11460 630626003343 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 630626003344 hypothetical protein; Provisional; Region: PRK13664 630626003345 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 630626003346 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 630626003347 metal binding site [ion binding]; metal-binding site 630626003348 dimer interface [polypeptide binding]; other site 630626003349 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 630626003350 ArsC family; Region: ArsC; pfam03960 630626003351 putative catalytic residues [active] 630626003352 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 630626003353 Protein export membrane protein; Region: SecD_SecF; cl14618 630626003354 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 630626003355 4Fe-4S binding domain; Region: Fer4; pfam00037 630626003356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 630626003357 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 630626003358 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 630626003359 dimer interface [polypeptide binding]; other site 630626003360 ADP-ribose binding site [chemical binding]; other site 630626003361 active site 630626003362 nudix motif; other site 630626003363 metal binding site [ion binding]; metal-binding site 630626003364 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 630626003365 transketolase; Reviewed; Region: PRK12753 630626003366 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 630626003367 TPP-binding site [chemical binding]; other site 630626003368 dimer interface [polypeptide binding]; other site 630626003369 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 630626003370 PYR/PP interface [polypeptide binding]; other site 630626003371 dimer interface [polypeptide binding]; other site 630626003372 TPP binding site [chemical binding]; other site 630626003373 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 630626003374 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 630626003375 Malic enzyme, N-terminal domain; Region: malic; pfam00390 630626003376 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 630626003377 putative NAD(P) binding site [chemical binding]; other site 630626003378 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 630626003379 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 630626003380 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 630626003381 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 630626003382 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 630626003383 active site 630626003384 metal binding site [ion binding]; metal-binding site 630626003385 putative acetyltransferase; Provisional; Region: PRK03624 630626003386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626003387 Coenzyme A binding pocket [chemical binding]; other site 630626003388 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 630626003389 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 630626003390 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 630626003391 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 630626003392 thiosulfate transporter subunit; Provisional; Region: PRK10852 630626003393 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 630626003394 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 630626003395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626003396 dimer interface [polypeptide binding]; other site 630626003397 conserved gate region; other site 630626003398 putative PBP binding loops; other site 630626003399 ABC-ATPase subunit interface; other site 630626003400 sulfate transport protein; Provisional; Region: cysT; CHL00187 630626003401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626003402 dimer interface [polypeptide binding]; other site 630626003403 conserved gate region; other site 630626003404 putative PBP binding loops; other site 630626003405 ABC-ATPase subunit interface; other site 630626003406 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 630626003407 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 630626003408 Walker A/P-loop; other site 630626003409 ATP binding site [chemical binding]; other site 630626003410 Q-loop/lid; other site 630626003411 ABC transporter signature motif; other site 630626003412 Walker B; other site 630626003413 D-loop; other site 630626003414 H-loop/switch region; other site 630626003415 TOBE-like domain; Region: TOBE_3; pfam12857 630626003416 cysteine synthase B; Region: cysM; TIGR01138 630626003417 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 630626003418 dimer interface [polypeptide binding]; other site 630626003419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626003420 catalytic residue [active] 630626003421 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 630626003422 HPr interaction site; other site 630626003423 glycerol kinase (GK) interaction site [polypeptide binding]; other site 630626003424 active site 630626003425 phosphorylation site [posttranslational modification] 630626003426 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 630626003427 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 630626003428 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 630626003429 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 630626003430 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 630626003431 dimerization domain swap beta strand [polypeptide binding]; other site 630626003432 regulatory protein interface [polypeptide binding]; other site 630626003433 active site 630626003434 regulatory phosphorylation site [posttranslational modification]; other site 630626003435 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 630626003436 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 630626003437 dimer interface [polypeptide binding]; other site 630626003438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626003439 catalytic residue [active] 630626003440 putative sulfate transport protein CysZ; Validated; Region: PRK04949 630626003441 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 630626003442 FtsZ protein binding site [polypeptide binding]; other site 630626003443 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 630626003444 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 630626003445 nucleotide binding pocket [chemical binding]; other site 630626003446 K-X-D-G motif; other site 630626003447 catalytic site [active] 630626003448 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 630626003449 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 630626003450 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 630626003451 Dimer interface [polypeptide binding]; other site 630626003452 BRCT sequence motif; other site 630626003453 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 630626003454 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 630626003455 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 630626003456 purine nucleoside phosphorylase; Provisional; Region: PRK08202 630626003457 nucleoside transporter; Region: 2A0110; TIGR00889 630626003458 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 630626003459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626003460 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 630626003461 putative dimerization interface [polypeptide binding]; other site 630626003462 putative substrate binding pocket [chemical binding]; other site 630626003463 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 630626003464 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 630626003465 active site 630626003466 HIGH motif; other site 630626003467 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 630626003468 active site 630626003469 KMSKS motif; other site 630626003470 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 630626003471 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 630626003472 MASE1; Region: MASE1; pfam05231 630626003473 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626003474 diguanylate cyclase; Region: GGDEF; smart00267 630626003475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626003476 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 630626003477 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 630626003478 Nucleoside recognition; Region: Gate; pfam07670 630626003479 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 630626003480 manganese transport protein MntH; Reviewed; Region: PRK00701 630626003481 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 630626003482 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 630626003483 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 630626003484 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 630626003485 dimer interface [polypeptide binding]; other site 630626003486 PYR/PP interface [polypeptide binding]; other site 630626003487 TPP binding site [chemical binding]; other site 630626003488 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 630626003489 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 630626003490 TPP-binding site [chemical binding]; other site 630626003491 dimer interface [polypeptide binding]; other site 630626003492 glucokinase; Provisional; Region: glk; PRK00292 630626003493 glucokinase, proteobacterial type; Region: glk; TIGR00749 630626003494 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 630626003495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003496 active site 630626003497 phosphorylation site [posttranslational modification] 630626003498 intermolecular recognition site; other site 630626003499 dimerization interface [polypeptide binding]; other site 630626003500 LytTr DNA-binding domain; Region: LytTR; pfam04397 630626003501 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 630626003502 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 630626003503 GAF domain; Region: GAF_3; pfam13492 630626003504 Histidine kinase; Region: His_kinase; pfam06580 630626003505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626003506 ATP binding site [chemical binding]; other site 630626003507 Mg2+ binding site [ion binding]; other site 630626003508 G-X-G motif; other site 630626003509 aminotransferase; Validated; Region: PRK08175 630626003510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626003511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626003512 homodimer interface [polypeptide binding]; other site 630626003513 catalytic residue [active] 630626003514 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 630626003515 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 630626003516 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 630626003517 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 630626003518 HSP70 interaction site [polypeptide binding]; other site 630626003519 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 630626003520 substrate binding site [polypeptide binding]; other site 630626003521 dimer interface [polypeptide binding]; other site 630626003522 aspartate racemase; Region: asp_race; TIGR00035 630626003523 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 630626003524 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 630626003525 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 630626003526 Sulfatase; Region: Sulfatase; cl17466 630626003527 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626003528 Ligand Binding Site [chemical binding]; other site 630626003529 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 630626003530 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 630626003531 dimer interface [polypeptide binding]; other site 630626003532 active site 630626003533 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 630626003534 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 630626003535 active site 630626003536 dimer interface [polypeptide binding]; other site 630626003537 metal binding site [ion binding]; metal-binding site 630626003538 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 630626003539 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626003540 Activator of aromatic catabolism; Region: XylR_N; pfam06505 630626003541 V4R domain; Region: V4R; pfam02830 630626003542 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 630626003543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626003544 Walker A motif; other site 630626003545 ATP binding site [chemical binding]; other site 630626003546 Walker B motif; other site 630626003547 arginine finger; other site 630626003548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 630626003549 putative metal dependent hydrolase; Provisional; Region: PRK11598 630626003550 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 630626003551 Sulfatase; Region: Sulfatase; pfam00884 630626003552 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 630626003553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003554 active site 630626003555 phosphorylation site [posttranslational modification] 630626003556 intermolecular recognition site; other site 630626003557 dimerization interface [polypeptide binding]; other site 630626003558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626003559 DNA binding residues [nucleotide binding] 630626003560 dimerization interface [polypeptide binding]; other site 630626003561 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 630626003562 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 630626003563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626003564 dimer interface [polypeptide binding]; other site 630626003565 phosphorylation site [posttranslational modification] 630626003566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626003567 ATP binding site [chemical binding]; other site 630626003568 Mg2+ binding site [ion binding]; other site 630626003569 G-X-G motif; other site 630626003570 tetrathionate reductase subunit B; Provisional; Region: PRK14993 630626003571 4Fe-4S binding domain; Region: Fer4; pfam00037 630626003572 tetrathionate reductase subunit C; Provisional; Region: PRK14992 630626003573 tetrathionate reductase subunit A; Provisional; Region: PRK14991 630626003574 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 630626003575 putative [Fe4-S4] binding site [ion binding]; other site 630626003576 putative molybdopterin cofactor binding site [chemical binding]; other site 630626003577 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 630626003578 putative molybdopterin cofactor binding site; other site 630626003579 Protein of unknown function (DUF770); Region: DUF770; pfam05591 630626003580 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 630626003581 Protein of unknown function (DUF877); Region: DUF877; pfam05943 630626003582 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 630626003583 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 630626003584 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 630626003585 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 630626003586 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 630626003587 ligand binding site [chemical binding]; other site 630626003588 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 630626003589 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 630626003590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626003591 Walker A motif; other site 630626003592 ATP binding site [chemical binding]; other site 630626003593 Walker B motif; other site 630626003594 arginine finger; other site 630626003595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626003596 Walker A motif; other site 630626003597 ATP binding site [chemical binding]; other site 630626003598 Walker B motif; other site 630626003599 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 630626003600 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 630626003601 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 630626003602 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 630626003603 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 630626003604 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 630626003605 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 630626003606 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 630626003607 Transposase; Region: HTH_Tnp_1; pfam01527 630626003608 HTH-like domain; Region: HTH_21; pfam13276 630626003609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626003610 Integrase core domain; Region: rve; pfam00665 630626003611 Integrase core domain; Region: rve_3; pfam13683 630626003612 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 630626003613 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 630626003614 Tetratricopeptide repeat; Region: TPR_12; pfam13424 630626003615 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 630626003616 catalytic residue [active] 630626003617 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 630626003618 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 630626003619 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 630626003620 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 630626003621 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 630626003622 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 630626003623 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 630626003624 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 630626003625 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 630626003626 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 630626003627 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 630626003628 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 630626003629 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 630626003630 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 630626003631 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 630626003632 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 630626003633 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 630626003634 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 630626003635 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 630626003636 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 630626003637 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 630626003638 ImpA domain protein; Region: DUF3702; pfam12486 630626003639 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 630626003640 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626003641 catalytic loop [active] 630626003642 iron binding site [ion binding]; other site 630626003643 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 630626003644 FAD binding pocket [chemical binding]; other site 630626003645 FAD binding motif [chemical binding]; other site 630626003646 phosphate binding motif [ion binding]; other site 630626003647 beta-alpha-beta structure motif; other site 630626003648 NAD binding pocket [chemical binding]; other site 630626003649 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 630626003650 inter-subunit interface; other site 630626003651 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 630626003652 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 630626003653 iron-sulfur cluster [ion binding]; other site 630626003654 [2Fe-2S] cluster binding site [ion binding]; other site 630626003655 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 630626003656 putative alpha subunit interface [polypeptide binding]; other site 630626003657 putative active site [active] 630626003658 putative substrate binding site [chemical binding]; other site 630626003659 Fe binding site [ion binding]; other site 630626003660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 630626003661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626003662 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 630626003663 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 630626003664 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 630626003665 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626003666 dimer interface [polypeptide binding]; other site 630626003667 active site 630626003668 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 630626003669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626003670 substrate binding site [chemical binding]; other site 630626003671 oxyanion hole (OAH) forming residues; other site 630626003672 trimer interface [polypeptide binding]; other site 630626003673 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 630626003674 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626003675 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626003676 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 630626003677 catalytic core [active] 630626003678 hypothetical protein; Provisional; Region: PRK04946 630626003679 Smr domain; Region: Smr; pfam01713 630626003680 HemK family putative methylases; Region: hemK_fam; TIGR00536 630626003681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626003682 S-adenosylmethionine binding site [chemical binding]; other site 630626003683 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 630626003684 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 630626003685 Tetramer interface [polypeptide binding]; other site 630626003686 active site 630626003687 FMN-binding site [chemical binding]; other site 630626003688 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 630626003689 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 630626003690 hypothetical protein; Provisional; Region: PRK10621 630626003691 Predicted permeases [General function prediction only]; Region: COG0730 630626003692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 630626003693 YfcL protein; Region: YfcL; pfam08891 630626003694 Uncharacterized conserved protein [Function unknown]; Region: COG4121 630626003695 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 630626003696 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 630626003697 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 630626003698 dimer interface [polypeptide binding]; other site 630626003699 active site 630626003700 putative transporter; Provisional; Region: PRK12382 630626003701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626003702 putative substrate translocation pore; other site 630626003703 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 630626003704 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 630626003705 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 630626003706 ligand binding site [chemical binding]; other site 630626003707 NAD binding site [chemical binding]; other site 630626003708 catalytic site [active] 630626003709 homodimer interface [polypeptide binding]; other site 630626003710 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 630626003711 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 630626003712 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 630626003713 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 630626003714 dimerization interface 3.5A [polypeptide binding]; other site 630626003715 active site 630626003716 hypothetical protein; Provisional; Region: PRK10847 630626003717 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 630626003718 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 630626003719 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 630626003720 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 630626003721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626003722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626003723 cell division protein DedD; Provisional; Region: PRK11633 630626003724 Sporulation related domain; Region: SPOR; pfam05036 630626003725 colicin V production protein; Provisional; Region: PRK10845 630626003726 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 630626003727 amidophosphoribosyltransferase; Provisional; Region: PRK09246 630626003728 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 630626003729 active site 630626003730 tetramer interface [polypeptide binding]; other site 630626003731 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626003732 active site 630626003733 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 630626003734 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626003735 substrate binding pocket [chemical binding]; other site 630626003736 membrane-bound complex binding site; other site 630626003737 hinge residues; other site 630626003738 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 630626003739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626003740 substrate binding pocket [chemical binding]; other site 630626003741 membrane-bound complex binding site; other site 630626003742 hinge residues; other site 630626003743 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626003744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626003745 dimer interface [polypeptide binding]; other site 630626003746 conserved gate region; other site 630626003747 putative PBP binding loops; other site 630626003748 ABC-ATPase subunit interface; other site 630626003749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626003750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626003751 dimer interface [polypeptide binding]; other site 630626003752 conserved gate region; other site 630626003753 putative PBP binding loops; other site 630626003754 ABC-ATPase subunit interface; other site 630626003755 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 630626003756 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 630626003757 Walker A/P-loop; other site 630626003758 ATP binding site [chemical binding]; other site 630626003759 Q-loop/lid; other site 630626003760 ABC transporter signature motif; other site 630626003761 Walker B; other site 630626003762 D-loop; other site 630626003763 H-loop/switch region; other site 630626003764 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 630626003765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626003766 NAD(P) binding site [chemical binding]; other site 630626003767 active site 630626003768 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 630626003769 homooctamer interface [polypeptide binding]; other site 630626003770 active site 630626003771 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 630626003772 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 630626003773 active site 630626003774 metal binding site [ion binding]; metal-binding site 630626003775 homotetramer interface [polypeptide binding]; other site 630626003776 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 630626003777 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 630626003778 nudix motif; other site 630626003779 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626003780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626003781 DNA binding site [nucleotide binding] 630626003782 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 630626003783 putative dimerization interface [polypeptide binding]; other site 630626003784 putative ligand binding site [chemical binding]; other site 630626003785 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 630626003786 active site 630626003787 phosphorylation site [posttranslational modification] 630626003788 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 630626003789 active site 630626003790 P-loop; other site 630626003791 phosphorylation site [posttranslational modification] 630626003792 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 630626003793 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 630626003794 TPP-binding site [chemical binding]; other site 630626003795 dimer interface [polypeptide binding]; other site 630626003796 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 630626003797 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 630626003798 PYR/PP interface [polypeptide binding]; other site 630626003799 dimer interface [polypeptide binding]; other site 630626003800 TPP binding site [chemical binding]; other site 630626003801 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 630626003802 Transcriptional regulators [Transcription]; Region: MarR; COG1846 630626003803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626003804 dimerization interface [polypeptide binding]; other site 630626003805 putative DNA binding site [nucleotide binding]; other site 630626003806 putative Zn2+ binding site [ion binding]; other site 630626003807 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 630626003808 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 630626003809 hypothetical protein; Provisional; Region: PRK07338 630626003810 metal binding site [ion binding]; metal-binding site 630626003811 dimer interface [polypeptide binding]; other site 630626003812 hypothetical protein; Provisional; Region: PRK10519 630626003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 630626003814 Nucleoside recognition; Region: Gate; pfam07670 630626003815 phosphate acetyltransferase; Reviewed; Region: PRK05632 630626003816 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 630626003817 DRTGG domain; Region: DRTGG; pfam07085 630626003818 phosphate acetyltransferase; Region: pta; TIGR00651 630626003819 propionate/acetate kinase; Provisional; Region: PRK12379 630626003820 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 630626003821 hypothetical protein; Provisional; Region: PRK01816 630626003822 hypothetical protein; Validated; Region: PRK05445 630626003823 putative phosphatase; Provisional; Region: PRK11587 630626003824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626003825 motif II; other site 630626003826 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 630626003827 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 630626003828 TrkA-C domain; Region: TrkA_C; pfam02080 630626003829 TrkA-C domain; Region: TrkA_C; pfam02080 630626003830 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 630626003831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626003832 Zn2+ binding site [ion binding]; other site 630626003833 Mg2+ binding site [ion binding]; other site 630626003834 aminotransferase AlaT; Validated; Region: PRK09265 630626003835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626003836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626003837 homodimer interface [polypeptide binding]; other site 630626003838 catalytic residue [active] 630626003839 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 630626003840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626003841 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 630626003842 putative dimerization interface [polypeptide binding]; other site 630626003843 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 630626003844 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 630626003845 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 630626003846 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 630626003847 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 630626003848 NADH dehydrogenase subunit E; Validated; Region: PRK07539 630626003849 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 630626003850 putative dimer interface [polypeptide binding]; other site 630626003851 [2Fe-2S] cluster binding site [ion binding]; other site 630626003852 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 630626003853 SLBB domain; Region: SLBB; pfam10531 630626003854 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 630626003855 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 630626003856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626003857 catalytic loop [active] 630626003858 iron binding site [ion binding]; other site 630626003859 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 630626003860 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 630626003861 [4Fe-4S] binding site [ion binding]; other site 630626003862 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 630626003863 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 630626003864 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 630626003865 4Fe-4S binding domain; Region: Fer4; pfam00037 630626003866 4Fe-4S binding domain; Region: Fer4; pfam00037 630626003867 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 630626003868 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 630626003869 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 630626003870 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 630626003871 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 630626003872 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626003873 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 630626003874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626003875 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 630626003876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626003877 Predicted ATPase [General function prediction only]; Region: COG3911 630626003878 AAA domain; Region: AAA_28; pfam13521 630626003879 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 630626003880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626003881 Coenzyme A binding pocket [chemical binding]; other site 630626003882 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 630626003883 chorismate binding enzyme; Region: Chorismate_bind; cl10555 630626003884 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 630626003885 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 630626003886 dimer interface [polypeptide binding]; other site 630626003887 tetramer interface [polypeptide binding]; other site 630626003888 PYR/PP interface [polypeptide binding]; other site 630626003889 TPP binding site [chemical binding]; other site 630626003890 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 630626003891 TPP-binding site; other site 630626003892 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 630626003893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626003894 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 630626003895 substrate binding site [chemical binding]; other site 630626003896 oxyanion hole (OAH) forming residues; other site 630626003897 trimer interface [polypeptide binding]; other site 630626003898 O-succinylbenzoate synthase; Provisional; Region: PRK05105 630626003899 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 630626003900 active site 630626003901 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 630626003902 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 630626003903 acyl-activating enzyme (AAE) consensus motif; other site 630626003904 putative AMP binding site [chemical binding]; other site 630626003905 putative active site [active] 630626003906 putative CoA binding site [chemical binding]; other site 630626003907 elongation factor G; Reviewed; Region: PRK00007 630626003908 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 630626003909 G1 box; other site 630626003910 putative GEF interaction site [polypeptide binding]; other site 630626003911 GTP/Mg2+ binding site [chemical binding]; other site 630626003912 Switch I region; other site 630626003913 G2 box; other site 630626003914 G3 box; other site 630626003915 Switch II region; other site 630626003916 G4 box; other site 630626003917 G5 box; other site 630626003918 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 630626003919 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 630626003920 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 630626003921 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 630626003922 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 630626003923 tetramer interface [polypeptide binding]; other site 630626003924 heme binding pocket [chemical binding]; other site 630626003925 NADPH binding site [chemical binding]; other site 630626003926 hypothetical protein; Provisional; Region: PRK03673 630626003927 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 630626003928 putative MPT binding site; other site 630626003929 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 630626003930 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626003931 Cysteine-rich domain; Region: CCG; pfam02754 630626003932 Cysteine-rich domain; Region: CCG; pfam02754 630626003933 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 630626003934 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 630626003935 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 630626003936 hydroxyglutarate oxidase; Provisional; Region: PRK11728 630626003937 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 630626003938 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 630626003939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626003940 putative substrate translocation pore; other site 630626003941 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 630626003942 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 630626003943 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 630626003944 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 630626003945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626003946 DNA-binding site [nucleotide binding]; DNA binding site 630626003947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626003948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626003949 homodimer interface [polypeptide binding]; other site 630626003950 catalytic residue [active] 630626003951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626003952 catalytic loop [active] 630626003953 iron binding site [ion binding]; other site 630626003954 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 630626003955 dimer interface [polypeptide binding]; other site 630626003956 putative radical transfer pathway; other site 630626003957 diiron center [ion binding]; other site 630626003958 tyrosyl radical; other site 630626003959 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 630626003960 ATP cone domain; Region: ATP-cone; pfam03477 630626003961 Class I ribonucleotide reductase; Region: RNR_I; cd01679 630626003962 active site 630626003963 dimer interface [polypeptide binding]; other site 630626003964 catalytic residues [active] 630626003965 effector binding site; other site 630626003966 R2 peptide binding site; other site 630626003967 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 630626003968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626003969 S-adenosylmethionine binding site [chemical binding]; other site 630626003970 DNA gyrase subunit A; Validated; Region: PRK05560 630626003971 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 630626003972 CAP-like domain; other site 630626003973 active site 630626003974 primary dimer interface [polypeptide binding]; other site 630626003975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003976 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003978 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003979 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003980 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 630626003981 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 630626003982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626003983 dimer interface [polypeptide binding]; other site 630626003984 phosphorylation site [posttranslational modification] 630626003985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626003986 ATP binding site [chemical binding]; other site 630626003987 Mg2+ binding site [ion binding]; other site 630626003988 G-X-G motif; other site 630626003989 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 630626003990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003991 active site 630626003992 phosphorylation site [posttranslational modification] 630626003993 intermolecular recognition site; other site 630626003994 dimerization interface [polypeptide binding]; other site 630626003995 transcriptional regulator RcsB; Provisional; Region: PRK10840 630626003996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626003997 active site 630626003998 phosphorylation site [posttranslational modification] 630626003999 intermolecular recognition site; other site 630626004000 dimerization interface [polypeptide binding]; other site 630626004001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626004002 DNA binding residues [nucleotide binding] 630626004003 dimerization interface [polypeptide binding]; other site 630626004004 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 630626004005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626004006 ATP binding site [chemical binding]; other site 630626004007 Mg2+ binding site [ion binding]; other site 630626004008 G-X-G motif; other site 630626004009 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 630626004010 putative binding surface; other site 630626004011 active site 630626004012 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 630626004013 outer membrane porin protein C; Provisional; Region: PRK10554 630626004014 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 630626004015 ApbE family; Region: ApbE; pfam02424 630626004016 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 630626004017 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 630626004018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626004019 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 630626004020 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 630626004021 DNA binding site [nucleotide binding] 630626004022 active site 630626004023 Domain of unknown function (DUF336); Region: DUF336; pfam03928 630626004024 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 630626004025 active site 630626004026 homotetramer interface [polypeptide binding]; other site 630626004027 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 630626004028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626004029 active site 630626004030 phosphorylation site [posttranslational modification] 630626004031 intermolecular recognition site; other site 630626004032 dimerization interface [polypeptide binding]; other site 630626004033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626004034 DNA binding site [nucleotide binding] 630626004035 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 630626004036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626004037 dimer interface [polypeptide binding]; other site 630626004038 phosphorylation site [posttranslational modification] 630626004039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626004040 ATP binding site [chemical binding]; other site 630626004041 Mg2+ binding site [ion binding]; other site 630626004042 G-X-G motif; other site 630626004043 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 630626004044 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 630626004045 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 630626004046 Walker A/P-loop; other site 630626004047 ATP binding site [chemical binding]; other site 630626004048 Q-loop/lid; other site 630626004049 ABC transporter signature motif; other site 630626004050 Walker B; other site 630626004051 D-loop; other site 630626004052 H-loop/switch region; other site 630626004053 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 630626004054 MgtE intracellular N domain; Region: MgtE_N; smart00924 630626004055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 630626004056 Divalent cation transporter; Region: MgtE; cl00786 630626004057 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 630626004058 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 630626004059 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 630626004060 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 630626004061 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 630626004062 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 630626004063 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 630626004064 Sulfatase; Region: Sulfatase; cl17466 630626004065 hypothetical protein; Provisional; Region: PRK13689 630626004066 Nucleoid-associated protein [General function prediction only]; Region: COG3081 630626004067 nucleoid-associated protein NdpA; Validated; Region: PRK00378 630626004068 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 630626004069 5S rRNA interface [nucleotide binding]; other site 630626004070 CTC domain interface [polypeptide binding]; other site 630626004071 L16 interface [polypeptide binding]; other site 630626004072 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 630626004073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626004074 ATP binding site [chemical binding]; other site 630626004075 putative Mg++ binding site [ion binding]; other site 630626004076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626004077 nucleotide binding region [chemical binding]; other site 630626004078 ATP-binding site [chemical binding]; other site 630626004079 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 630626004080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626004081 RNA binding surface [nucleotide binding]; other site 630626004082 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 630626004083 active site 630626004084 uracil binding [chemical binding]; other site 630626004085 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 630626004086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004087 putative substrate translocation pore; other site 630626004088 hypothetical protein; Provisional; Region: PRK11835 630626004089 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 630626004090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626004091 Walker A/P-loop; other site 630626004092 ATP binding site [chemical binding]; other site 630626004093 Q-loop/lid; other site 630626004094 ABC transporter signature motif; other site 630626004095 Walker B; other site 630626004096 D-loop; other site 630626004097 H-loop/switch region; other site 630626004098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 630626004099 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626004100 Walker A/P-loop; other site 630626004101 ATP binding site [chemical binding]; other site 630626004102 Q-loop/lid; other site 630626004103 ABC transporter signature motif; other site 630626004104 Walker B; other site 630626004105 D-loop; other site 630626004106 H-loop/switch region; other site 630626004107 microcin C ABC transporter permease; Provisional; Region: PRK15021 630626004108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626004109 dimer interface [polypeptide binding]; other site 630626004110 conserved gate region; other site 630626004111 putative PBP binding loops; other site 630626004112 ABC-ATPase subunit interface; other site 630626004113 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 630626004114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626004115 dimer interface [polypeptide binding]; other site 630626004116 conserved gate region; other site 630626004117 putative PBP binding loops; other site 630626004118 ABC-ATPase subunit interface; other site 630626004119 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 630626004120 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 630626004121 phage resistance protein; Provisional; Region: PRK10551 630626004122 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 630626004123 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626004124 NlpC/P60 family; Region: NLPC_P60; pfam00877 630626004125 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 630626004126 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 630626004127 active site 630626004128 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 630626004129 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 630626004130 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 630626004131 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 630626004132 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 630626004133 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 630626004134 elongation factor P; Provisional; Region: PRK04542 630626004135 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 630626004136 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 630626004137 RNA binding site [nucleotide binding]; other site 630626004138 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 630626004139 RNA binding site [nucleotide binding]; other site 630626004140 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 630626004141 Sulfatase; Region: Sulfatase; cl17466 630626004142 Flagellin N-methylase; Region: FliB; cl00497 630626004143 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 630626004144 catalytic triad [active] 630626004145 putative active site [active] 630626004146 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 630626004147 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 630626004148 Autotransporter beta-domain; Region: Autotransporter; pfam03797 630626004149 sugar efflux transporter B; Provisional; Region: PRK15011 630626004150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004151 putative substrate translocation pore; other site 630626004152 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 630626004153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 630626004154 active site 630626004155 phosphorylation site [posttranslational modification] 630626004156 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 630626004157 dimerization domain swap beta strand [polypeptide binding]; other site 630626004158 regulatory protein interface [polypeptide binding]; other site 630626004159 active site 630626004160 regulatory phosphorylation site [posttranslational modification]; other site 630626004161 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 630626004162 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 630626004163 putative substrate binding site [chemical binding]; other site 630626004164 putative ATP binding site [chemical binding]; other site 630626004165 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 630626004166 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 630626004167 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 630626004168 active site 630626004169 P-loop; other site 630626004170 phosphorylation site [posttranslational modification] 630626004171 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 630626004172 endonuclease IV; Provisional; Region: PRK01060 630626004173 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 630626004174 AP (apurinic/apyrimidinic) site pocket; other site 630626004175 DNA interaction; other site 630626004176 Metal-binding active site; metal-binding site 630626004177 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 630626004178 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 630626004179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626004180 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 630626004181 putative dimerization interface [polypeptide binding]; other site 630626004182 lysine transporter; Provisional; Region: PRK10836 630626004183 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 630626004184 S-formylglutathione hydrolase; Region: PLN02442 630626004185 GTP cyclohydrolase I; Provisional; Region: PLN03044 630626004186 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 630626004187 active site 630626004188 Predicted membrane protein [Function unknown]; Region: COG2311 630626004189 hypothetical protein; Provisional; Region: PRK10835 630626004190 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 630626004191 putative active site [active] 630626004192 cytidine deaminase; Provisional; Region: PRK09027 630626004193 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 630626004194 active site 630626004195 catalytic motif [active] 630626004196 Zn binding site [ion binding]; other site 630626004197 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 630626004198 active site 630626004199 catalytic motif [active] 630626004200 Zn binding site [ion binding]; other site 630626004201 hypothetical protein; Provisional; Region: PRK10711 630626004202 hypothetical protein; Provisional; Region: PRK01821 630626004203 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 630626004204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626004205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626004206 dimerization interface [polypeptide binding]; other site 630626004207 benzoate transport; Region: 2A0115; TIGR00895 630626004208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004209 putative substrate translocation pore; other site 630626004210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004211 putative substrate translocation pore; other site 630626004212 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 630626004213 Cupin domain; Region: Cupin_2; pfam07883 630626004214 Cupin domain; Region: Cupin_2; pfam07883 630626004215 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 630626004216 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 630626004217 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 630626004218 maleylacetoacetate isomerase; Region: maiA; TIGR01262 630626004219 C-terminal domain interface [polypeptide binding]; other site 630626004220 GSH binding site (G-site) [chemical binding]; other site 630626004221 putative dimer interface [polypeptide binding]; other site 630626004222 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 630626004223 dimer interface [polypeptide binding]; other site 630626004224 N-terminal domain interface [polypeptide binding]; other site 630626004225 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 630626004226 salicylate hydroxylase; Provisional; Region: PRK08163 630626004227 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626004228 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 630626004229 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 630626004230 FMN binding site [chemical binding]; other site 630626004231 active site 630626004232 catalytic residues [active] 630626004233 substrate binding site [chemical binding]; other site 630626004234 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 630626004235 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 630626004236 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 630626004237 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 630626004238 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 630626004239 D-lactate dehydrogenase; Provisional; Region: PRK11183 630626004240 FAD binding domain; Region: FAD_binding_4; pfam01565 630626004241 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 630626004242 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 630626004243 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 630626004244 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 630626004245 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 630626004246 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 630626004247 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 630626004248 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 630626004249 Walker A/P-loop; other site 630626004250 ATP binding site [chemical binding]; other site 630626004251 Q-loop/lid; other site 630626004252 ABC transporter signature motif; other site 630626004253 Walker B; other site 630626004254 D-loop; other site 630626004255 H-loop/switch region; other site 630626004256 CBS domain; Region: CBS; pfam00571 630626004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626004258 putative PBP binding loops; other site 630626004259 ABC-ATPase subunit interface; other site 630626004260 outer membrane receptor FepA; Provisional; Region: PRK13524 630626004261 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626004262 N-terminal plug; other site 630626004263 ligand-binding site [chemical binding]; other site 630626004264 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 630626004265 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 630626004266 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 630626004267 MbtH-like protein; Region: MbtH; cl01279 630626004268 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 630626004269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 630626004270 acyl-activating enzyme (AAE) consensus motif; other site 630626004271 AMP binding site [chemical binding]; other site 630626004272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 630626004273 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 630626004274 active site 630626004275 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 630626004276 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626004277 Walker A/P-loop; other site 630626004278 ATP binding site [chemical binding]; other site 630626004279 Q-loop/lid; other site 630626004280 ABC transporter signature motif; other site 630626004281 Walker B; other site 630626004282 D-loop; other site 630626004283 H-loop/switch region; other site 630626004284 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 630626004285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626004286 ABC-ATPase subunit interface; other site 630626004287 dimer interface [polypeptide binding]; other site 630626004288 putative PBP binding regions; other site 630626004289 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626004290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626004291 ABC-ATPase subunit interface; other site 630626004292 dimer interface [polypeptide binding]; other site 630626004293 putative PBP binding regions; other site 630626004294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004295 H+ Antiporter protein; Region: 2A0121; TIGR00900 630626004296 putative substrate translocation pore; other site 630626004297 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 630626004298 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 630626004299 siderophore binding site; other site 630626004300 isochorismate synthase EntC; Provisional; Region: PRK15016 630626004301 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 630626004302 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 630626004303 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 630626004304 acyl-activating enzyme (AAE) consensus motif; other site 630626004305 active site 630626004306 AMP binding site [chemical binding]; other site 630626004307 substrate binding site [chemical binding]; other site 630626004308 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 630626004309 hydrophobic substrate binding pocket; other site 630626004310 Isochorismatase family; Region: Isochorismatase; pfam00857 630626004311 active site 630626004312 conserved cis-peptide bond; other site 630626004313 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 630626004314 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 630626004315 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 630626004316 putative NAD(P) binding site [chemical binding]; other site 630626004317 active site 630626004318 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 630626004319 CoenzymeA binding site [chemical binding]; other site 630626004320 subunit interaction site [polypeptide binding]; other site 630626004321 PHB binding site; other site 630626004322 carbon starvation protein A; Provisional; Region: PRK15015 630626004323 Carbon starvation protein CstA; Region: CstA; pfam02554 630626004324 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 630626004325 Uncharacterized small protein [Function unknown]; Region: COG2879 630626004326 methionine aminotransferase; Validated; Region: PRK09082 630626004327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626004328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626004329 homodimer interface [polypeptide binding]; other site 630626004330 catalytic residue [active] 630626004331 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 630626004332 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 630626004333 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 630626004334 dimerization domain [polypeptide binding]; other site 630626004335 dimer interface [polypeptide binding]; other site 630626004336 catalytic residues [active] 630626004337 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 630626004338 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 630626004339 dimer interface [polypeptide binding]; other site 630626004340 decamer (pentamer of dimers) interface [polypeptide binding]; other site 630626004341 catalytic triad [active] 630626004342 peroxidatic and resolving cysteines [active] 630626004343 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 630626004344 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 630626004345 catalytic residue [active] 630626004346 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 630626004347 catalytic residues [active] 630626004348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 630626004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626004350 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626004351 Ligand Binding Site [chemical binding]; other site 630626004352 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 630626004353 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 630626004354 active site 630626004355 HIGH motif; other site 630626004356 KMSKS motif; other site 630626004357 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 630626004358 tRNA binding surface [nucleotide binding]; other site 630626004359 anticodon binding site; other site 630626004360 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 630626004361 dimer interface [polypeptide binding]; other site 630626004362 putative tRNA-binding site [nucleotide binding]; other site 630626004363 antiporter inner membrane protein; Provisional; Region: PRK11670 630626004364 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 630626004365 Walker A motif; other site 630626004366 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 630626004367 transcriptional activator TtdR; Provisional; Region: PRK09801 630626004368 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 630626004369 putative effector binding pocket; other site 630626004370 putative dimerization interface [polypeptide binding]; other site 630626004371 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 630626004372 tartrate dehydrogenase; Region: TTC; TIGR02089 630626004373 putative transporter; Provisional; Region: PRK09950 630626004374 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 630626004375 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 630626004376 [2Fe-2S] cluster binding site [ion binding]; other site 630626004377 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 630626004378 putative alpha subunit interface [polypeptide binding]; other site 630626004379 putative active site [active] 630626004380 putative substrate binding site [chemical binding]; other site 630626004381 Fe binding site [ion binding]; other site 630626004382 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 630626004383 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 630626004384 FMN-binding pocket [chemical binding]; other site 630626004385 flavin binding motif; other site 630626004386 phosphate binding motif [ion binding]; other site 630626004387 beta-alpha-beta structure motif; other site 630626004388 NAD binding pocket [chemical binding]; other site 630626004389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626004390 catalytic loop [active] 630626004391 iron binding site [ion binding]; other site 630626004392 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 630626004393 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 630626004394 inhibitor-cofactor binding pocket; inhibition site 630626004395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626004396 catalytic residue [active] 630626004397 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 630626004398 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 630626004399 Ligand binding site; other site 630626004400 Putative Catalytic site; other site 630626004401 DXD motif; other site 630626004402 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 630626004403 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 630626004404 active site 630626004405 substrate binding site [chemical binding]; other site 630626004406 cosubstrate binding site; other site 630626004407 catalytic site [active] 630626004408 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 630626004409 active site 630626004410 hexamer interface [polypeptide binding]; other site 630626004411 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 630626004412 NAD binding site [chemical binding]; other site 630626004413 substrate binding site [chemical binding]; other site 630626004414 active site 630626004415 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 630626004416 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 630626004417 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 630626004418 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 630626004419 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 630626004420 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 630626004421 Protein of unknown function (DUF796); Region: DUF796; cl01226 630626004422 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 630626004423 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 630626004424 substrate binding site [chemical binding]; other site 630626004425 multimerization interface [polypeptide binding]; other site 630626004426 ATP binding site [chemical binding]; other site 630626004427 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 630626004428 dimer interface [polypeptide binding]; other site 630626004429 substrate binding site [chemical binding]; other site 630626004430 ATP binding site [chemical binding]; other site 630626004431 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 630626004432 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 630626004433 putative active site; other site 630626004434 catalytic residue [active] 630626004435 putative protease; Provisional; Region: PRK15452 630626004436 Peptidase family U32; Region: Peptidase_U32; pfam01136 630626004437 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 630626004438 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 630626004439 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 630626004440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626004441 active site 630626004442 phosphorylation site [posttranslational modification] 630626004443 intermolecular recognition site; other site 630626004444 dimerization interface [polypeptide binding]; other site 630626004445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626004446 DNA binding site [nucleotide binding] 630626004447 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 630626004448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626004449 dimerization interface [polypeptide binding]; other site 630626004450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626004451 dimer interface [polypeptide binding]; other site 630626004452 phosphorylation site [posttranslational modification] 630626004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626004454 ATP binding site [chemical binding]; other site 630626004455 Mg2+ binding site [ion binding]; other site 630626004456 G-X-G motif; other site 630626004457 putative transporter; Provisional; Region: PRK10504 630626004458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004459 putative substrate translocation pore; other site 630626004460 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 630626004461 Protein export membrane protein; Region: SecD_SecF; cl14618 630626004462 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 630626004463 Protein export membrane protein; Region: SecD_SecF; cl14618 630626004464 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 630626004465 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626004466 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626004467 putative chaperone; Provisional; Region: PRK11678 630626004468 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 630626004469 nucleotide binding site [chemical binding]; other site 630626004470 putative NEF/HSP70 interaction site [polypeptide binding]; other site 630626004471 SBD interface [polypeptide binding]; other site 630626004472 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 630626004473 AlkA N-terminal domain; Region: AlkA_N; pfam06029 630626004474 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 630626004475 minor groove reading motif; other site 630626004476 helix-hairpin-helix signature motif; other site 630626004477 substrate binding pocket [chemical binding]; other site 630626004478 active site 630626004479 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 630626004480 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 630626004481 ATP-binding site [chemical binding]; other site 630626004482 Sugar specificity; other site 630626004483 Pyrimidine base specificity; other site 630626004484 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 630626004485 trimer interface [polypeptide binding]; other site 630626004486 active site 630626004487 putative assembly protein; Provisional; Region: PRK10833 630626004488 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 630626004489 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 630626004490 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 630626004491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 630626004492 Transporter associated domain; Region: CorC_HlyC; smart01091 630626004493 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 630626004494 active site 630626004495 tetramer interface; other site 630626004496 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 630626004497 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 630626004498 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 630626004499 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 630626004500 Walker A/P-loop; other site 630626004501 ATP binding site [chemical binding]; other site 630626004502 Q-loop/lid; other site 630626004503 ABC transporter signature motif; other site 630626004504 Walker B; other site 630626004505 D-loop; other site 630626004506 H-loop/switch region; other site 630626004507 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 630626004508 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 630626004509 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 630626004510 Ligand binding site; other site 630626004511 metal-binding site 630626004512 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 630626004513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 630626004514 UDP-galactopyranose mutase; Region: GLF; pfam03275 630626004515 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 630626004516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626004517 active site 630626004518 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 630626004519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626004520 putative ADP-binding pocket [chemical binding]; other site 630626004521 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 630626004522 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 630626004523 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 630626004524 Acyltransferase family; Region: Acyl_transf_3; pfam01757 630626004525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 630626004526 active site 630626004527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 630626004528 active site 630626004529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 630626004530 active site 630626004531 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 630626004532 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 630626004533 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 630626004534 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 630626004535 metal binding site [ion binding]; metal-binding site 630626004536 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 630626004537 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 630626004538 substrate binding site [chemical binding]; other site 630626004539 glutamase interaction surface [polypeptide binding]; other site 630626004540 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 630626004541 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 630626004542 catalytic residues [active] 630626004543 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 630626004544 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 630626004545 putative active site [active] 630626004546 oxyanion strand; other site 630626004547 catalytic triad [active] 630626004548 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 630626004549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626004550 active site 630626004551 motif I; other site 630626004552 motif II; other site 630626004553 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 630626004554 putative active site pocket [active] 630626004555 4-fold oligomerization interface [polypeptide binding]; other site 630626004556 metal binding residues [ion binding]; metal-binding site 630626004557 3-fold/trimer interface [polypeptide binding]; other site 630626004558 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 630626004559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626004560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626004561 homodimer interface [polypeptide binding]; other site 630626004562 catalytic residue [active] 630626004563 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 630626004564 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 630626004565 NAD binding site [chemical binding]; other site 630626004566 dimerization interface [polypeptide binding]; other site 630626004567 product binding site; other site 630626004568 substrate binding site [chemical binding]; other site 630626004569 zinc binding site [ion binding]; other site 630626004570 catalytic residues [active] 630626004571 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 630626004572 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 630626004573 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 630626004574 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 630626004575 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 630626004576 putative NAD(P) binding site [chemical binding]; other site 630626004577 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 630626004578 exonuclease I; Provisional; Region: sbcB; PRK11779 630626004579 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 630626004580 active site 630626004581 catalytic site [active] 630626004582 substrate binding site [chemical binding]; other site 630626004583 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 630626004584 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 630626004585 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 630626004586 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 630626004587 DNA gyrase inhibitor; Provisional; Region: PRK10016 630626004588 Predicted membrane protein [Function unknown]; Region: COG1289 630626004589 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 630626004590 hypothetical protein; Provisional; Region: PRK05423 630626004591 DNA binding domain, excisionase family; Region: excise; TIGR01764 630626004592 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 630626004593 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 630626004594 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 630626004595 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 630626004596 catalytic triad [active] 630626004597 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 630626004598 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 630626004599 Precorrin-8X methylmutase; Region: CbiC; pfam02570 630626004600 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 630626004601 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 630626004602 active site 630626004603 putative homodimer interface [polypeptide binding]; other site 630626004604 SAM binding site [chemical binding]; other site 630626004605 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 630626004606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626004607 S-adenosylmethionine binding site [chemical binding]; other site 630626004608 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 630626004609 active site 630626004610 SAM binding site [chemical binding]; other site 630626004611 homodimer interface [polypeptide binding]; other site 630626004612 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 630626004613 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 630626004614 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 630626004615 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 630626004616 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 630626004617 active site 630626004618 SAM binding site [chemical binding]; other site 630626004619 homodimer interface [polypeptide binding]; other site 630626004620 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 630626004621 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 630626004622 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 630626004623 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 630626004624 active site 630626004625 C-terminal domain interface [polypeptide binding]; other site 630626004626 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 630626004627 active site 630626004628 N-terminal domain interface [polypeptide binding]; other site 630626004629 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 630626004630 active site 630626004631 SAM binding site [chemical binding]; other site 630626004632 homodimer interface [polypeptide binding]; other site 630626004633 cobalt transport protein CbiM; Validated; Region: PRK08319 630626004634 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 630626004635 cobalt transport protein CbiN; Provisional; Region: PRK02898 630626004636 cobalt transport protein CbiQ; Provisional; Region: PRK15485 630626004637 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 630626004638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 630626004639 Walker A/P-loop; other site 630626004640 ATP binding site [chemical binding]; other site 630626004641 Q-loop/lid; other site 630626004642 ABC transporter signature motif; other site 630626004643 Walker B; other site 630626004644 D-loop; other site 630626004645 H-loop/switch region; other site 630626004646 cobyric acid synthase; Provisional; Region: PRK00784 630626004647 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 630626004648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 630626004649 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 630626004650 catalytic triad [active] 630626004651 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 630626004652 homotrimer interface [polypeptide binding]; other site 630626004653 Walker A motif; other site 630626004654 GTP binding site [chemical binding]; other site 630626004655 Walker B motif; other site 630626004656 cobalamin synthase; Reviewed; Region: cobS; PRK00235 630626004657 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 630626004658 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 630626004659 putative dimer interface [polypeptide binding]; other site 630626004660 active site pocket [active] 630626004661 putative cataytic base [active] 630626004662 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 630626004663 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 630626004664 proline/glycine betaine transporter; Provisional; Region: PRK10642 630626004665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004666 putative substrate translocation pore; other site 630626004667 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 630626004668 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 630626004669 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 630626004670 XdhC Rossmann domain; Region: XdhC_C; pfam13478 630626004671 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 630626004672 Ligand binding site; other site 630626004673 metal-binding site 630626004674 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 630626004675 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 630626004676 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 630626004677 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 630626004678 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 630626004679 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 630626004680 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 630626004681 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 630626004682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626004683 MarR family; Region: MarR; pfam01047 630626004684 MATE family multidrug exporter; Provisional; Region: PRK10189 630626004685 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 630626004686 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 630626004687 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 630626004688 mannonate dehydratase; Provisional; Region: PRK03906 630626004689 mannonate dehydratase; Region: uxuA; TIGR00695 630626004690 L,D-transpeptidase; Provisional; Region: PRK10190 630626004691 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626004692 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 630626004693 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 630626004694 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 630626004695 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 630626004696 FMN-binding pocket [chemical binding]; other site 630626004697 flavin binding motif; other site 630626004698 phosphate binding motif [ion binding]; other site 630626004699 beta-alpha-beta structure motif; other site 630626004700 NAD binding pocket [chemical binding]; other site 630626004701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626004702 catalytic loop [active] 630626004703 iron binding site [ion binding]; other site 630626004704 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 630626004705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 630626004706 PAS fold; Region: PAS_4; pfam08448 630626004707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626004708 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 630626004709 Walker A motif; other site 630626004710 ATP binding site [chemical binding]; other site 630626004711 Walker B motif; other site 630626004712 arginine finger; other site 630626004713 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 630626004714 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 630626004715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 630626004716 shikimate transporter; Provisional; Region: PRK09952 630626004717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004718 putative substrate translocation pore; other site 630626004719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626004721 putative substrate translocation pore; other site 630626004722 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 630626004723 PAAR motif; Region: PAAR_motif; pfam05488 630626004724 AMP nucleosidase; Provisional; Region: PRK08292 630626004725 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 630626004726 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 630626004727 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 630626004728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626004729 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 630626004730 putative dimerization interface [polypeptide binding]; other site 630626004731 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 630626004732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626004733 dimerization interface [polypeptide binding]; other site 630626004734 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 630626004735 PemK-like protein; Region: PemK; cl00995 630626004736 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 630626004737 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 630626004738 DNA cytosine methylase; Provisional; Region: PRK10458 630626004739 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 630626004740 cofactor binding site; other site 630626004741 DNA binding site [nucleotide binding] 630626004742 substrate interaction site [chemical binding]; other site 630626004743 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 630626004744 additional DNA contacts [nucleotide binding]; other site 630626004745 mismatch recognition site; other site 630626004746 active site 630626004747 zinc binding site [ion binding]; other site 630626004748 DNA intercalation site [nucleotide binding]; other site 630626004749 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 630626004750 EamA-like transporter family; Region: EamA; pfam00892 630626004751 EamA-like transporter family; Region: EamA; pfam00892 630626004752 Protein of unknown function (DUF808); Region: DUF808; cl01002 630626004753 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 630626004754 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 630626004755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626004756 metal binding site [ion binding]; metal-binding site 630626004757 active site 630626004758 I-site; other site 630626004759 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 630626004760 hypothetical protein; Provisional; Region: PRK10708 630626004761 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 630626004762 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626004763 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626004764 putative active site [active] 630626004765 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 630626004766 CPxP motif; other site 630626004767 putative inner membrane protein; Provisional; Region: PRK11099 630626004768 lipoprotein; Provisional; Region: PRK10397 630626004769 cystine transporter subunit; Provisional; Region: PRK11260 630626004770 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626004771 substrate binding pocket [chemical binding]; other site 630626004772 membrane-bound complex binding site; other site 630626004773 hinge residues; other site 630626004774 D-cysteine desulfhydrase; Validated; Region: PRK03910 630626004775 pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family; Region: ACC_deam_rel; TIGR01275 630626004776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626004777 catalytic residue [active] 630626004778 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626004779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626004780 dimer interface [polypeptide binding]; other site 630626004781 conserved gate region; other site 630626004782 putative PBP binding loops; other site 630626004783 ABC-ATPase subunit interface; other site 630626004784 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 630626004785 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 630626004786 Walker A/P-loop; other site 630626004787 ATP binding site [chemical binding]; other site 630626004788 Q-loop/lid; other site 630626004789 ABC transporter signature motif; other site 630626004790 Walker B; other site 630626004791 D-loop; other site 630626004792 H-loop/switch region; other site 630626004793 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 630626004794 Autoinducer binding domain; Region: Autoind_bind; pfam03472 630626004795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626004796 DNA binding residues [nucleotide binding] 630626004797 dimerization interface [polypeptide binding]; other site 630626004798 hypothetical protein; Provisional; Region: PRK10613 630626004799 response regulator; Provisional; Region: PRK09483 630626004800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626004801 active site 630626004802 phosphorylation site [posttranslational modification] 630626004803 intermolecular recognition site; other site 630626004804 dimerization interface [polypeptide binding]; other site 630626004805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626004806 DNA binding residues [nucleotide binding] 630626004807 dimerization interface [polypeptide binding]; other site 630626004808 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 630626004809 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 630626004810 GIY-YIG motif/motif A; other site 630626004811 active site 630626004812 catalytic site [active] 630626004813 putative DNA binding site [nucleotide binding]; other site 630626004814 metal binding site [ion binding]; metal-binding site 630626004815 UvrB/uvrC motif; Region: UVR; pfam02151 630626004816 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 630626004817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 630626004818 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 630626004819 yecA family protein; Region: ygfB_yecA; TIGR02292 630626004820 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626004821 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 630626004822 tyrosine transporter TyrP; Provisional; Region: PRK15132 630626004823 aromatic amino acid transport protein; Region: araaP; TIGR00837 630626004824 hypothetical protein; Provisional; Region: PRK09273 630626004825 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 630626004826 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 630626004827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 630626004828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626004829 Coenzyme A binding pocket [chemical binding]; other site 630626004830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626004832 putative substrate translocation pore; other site 630626004833 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 630626004834 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 630626004835 homodimer interface [polypeptide binding]; other site 630626004836 substrate-cofactor binding pocket; other site 630626004837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626004838 catalytic residue [active] 630626004839 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 630626004840 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 630626004841 Ferritin-like domain; Region: Ferritin; pfam00210 630626004842 ferroxidase diiron center [ion binding]; other site 630626004843 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 630626004844 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 630626004845 ligand binding site [chemical binding]; other site 630626004846 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 630626004847 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 630626004848 Walker A/P-loop; other site 630626004849 ATP binding site [chemical binding]; other site 630626004850 Q-loop/lid; other site 630626004851 ABC transporter signature motif; other site 630626004852 Walker B; other site 630626004853 D-loop; other site 630626004854 H-loop/switch region; other site 630626004855 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 630626004856 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626004857 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626004858 TM-ABC transporter signature motif; other site 630626004859 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 630626004860 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 630626004861 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 630626004862 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 630626004863 active site 630626004864 homotetramer interface [polypeptide binding]; other site 630626004865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626004866 Ligand Binding Site [chemical binding]; other site 630626004867 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 630626004868 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 630626004869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626004870 Walker A motif; other site 630626004871 ATP binding site [chemical binding]; other site 630626004872 Walker B motif; other site 630626004873 arginine finger; other site 630626004874 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 630626004875 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 630626004876 homodimer interface [polypeptide binding]; other site 630626004877 NAD binding pocket [chemical binding]; other site 630626004878 ATP binding pocket [chemical binding]; other site 630626004879 Mg binding site [ion binding]; other site 630626004880 active-site loop [active] 630626004881 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 630626004882 cell division modulator; Provisional; Region: PRK10113 630626004883 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 630626004884 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 630626004885 inner membrane protein; Provisional; Region: PRK11648 630626004886 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 630626004887 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 630626004888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626004889 motif II; other site 630626004890 YniB-like protein; Region: YniB; pfam14002 630626004891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 630626004892 Phosphotransferase enzyme family; Region: APH; pfam01636 630626004893 Protein of unknown function, DUF481; Region: DUF481; cl01213 630626004894 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 630626004895 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 630626004896 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 630626004897 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 630626004898 active site 630626004899 dimer interface [polypeptide binding]; other site 630626004900 motif 1; other site 630626004901 motif 2; other site 630626004902 motif 3; other site 630626004903 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 630626004904 anticodon binding site; other site 630626004905 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 630626004906 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 630626004907 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 630626004908 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 630626004909 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 630626004910 23S rRNA binding site [nucleotide binding]; other site 630626004911 L21 binding site [polypeptide binding]; other site 630626004912 L13 binding site [polypeptide binding]; other site 630626004913 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 630626004914 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 630626004915 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 630626004916 dimer interface [polypeptide binding]; other site 630626004917 motif 1; other site 630626004918 active site 630626004919 motif 2; other site 630626004920 motif 3; other site 630626004921 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 630626004922 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 630626004923 putative tRNA-binding site [nucleotide binding]; other site 630626004924 B3/4 domain; Region: B3_4; pfam03483 630626004925 tRNA synthetase B5 domain; Region: B5; smart00874 630626004926 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 630626004927 dimer interface [polypeptide binding]; other site 630626004928 motif 1; other site 630626004929 motif 3; other site 630626004930 motif 2; other site 630626004931 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 630626004932 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 630626004933 IHF dimer interface [polypeptide binding]; other site 630626004934 IHF - DNA interface [nucleotide binding]; other site 630626004935 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 630626004936 homotrimer interaction site [polypeptide binding]; other site 630626004937 putative active site [active] 630626004938 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626004939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626004940 ABC-ATPase subunit interface; other site 630626004941 dimer interface [polypeptide binding]; other site 630626004942 putative PBP binding regions; other site 630626004943 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 630626004944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626004945 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 630626004946 dimerization interface [polypeptide binding]; other site 630626004947 substrate binding pocket [chemical binding]; other site 630626004948 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 630626004949 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 630626004950 putative ligand binding site [chemical binding]; other site 630626004951 NAD binding site [chemical binding]; other site 630626004952 catalytic site [active] 630626004953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626004954 D-galactonate transporter; Region: 2A0114; TIGR00893 630626004955 putative substrate translocation pore; other site 630626004956 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 630626004957 catalytic residues [active] 630626004958 dimer interface [polypeptide binding]; other site 630626004959 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 630626004960 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626004961 Walker A/P-loop; other site 630626004962 ATP binding site [chemical binding]; other site 630626004963 Q-loop/lid; other site 630626004964 ABC transporter signature motif; other site 630626004965 Walker B; other site 630626004966 D-loop; other site 630626004967 H-loop/switch region; other site 630626004968 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 630626004969 NlpC/P60 family; Region: NLPC_P60; pfam00877 630626004970 hypothetical protein; Validated; Region: PRK00029 630626004971 Uncharacterized conserved protein [Function unknown]; Region: COG0397 630626004972 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 630626004973 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 630626004974 PEP synthetase regulatory protein; Provisional; Region: PRK05339 630626004975 phosphoenolpyruvate synthase; Validated; Region: PRK06464 630626004976 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 630626004977 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 630626004978 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 630626004979 putative inner membrane protein; Provisional; Region: PRK10983 630626004980 Domain of unknown function DUF20; Region: UPF0118; pfam01594 630626004981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626004982 DNA-binding site [nucleotide binding]; DNA binding site 630626004983 RNA-binding motif; other site 630626004984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 630626004985 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 630626004986 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 630626004987 substrate binding site [chemical binding]; other site 630626004988 active site 630626004989 catalytic residues [active] 630626004990 heterodimer interface [polypeptide binding]; other site 630626004991 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 630626004992 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 630626004993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626004994 catalytic residue [active] 630626004995 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 630626004996 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 630626004997 active site 630626004998 ribulose/triose binding site [chemical binding]; other site 630626004999 phosphate binding site [ion binding]; other site 630626005000 substrate (anthranilate) binding pocket [chemical binding]; other site 630626005001 product (indole) binding pocket [chemical binding]; other site 630626005002 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 630626005003 active site 630626005004 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 630626005005 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 630626005006 glutamine binding [chemical binding]; other site 630626005007 catalytic triad [active] 630626005008 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 630626005009 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 630626005010 anthranilate synthase component I; Provisional; Region: PRK13564 630626005011 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 630626005012 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 630626005013 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 630626005014 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 630626005015 active site 630626005016 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 630626005017 hypothetical protein; Provisional; Region: PRK11630 630626005018 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 630626005019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626005020 RNA binding surface [nucleotide binding]; other site 630626005021 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 630626005022 probable active site [active] 630626005023 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 630626005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005025 putative substrate translocation pore; other site 630626005026 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 630626005027 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 630626005028 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 630626005029 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 630626005030 Cupin domain; Region: Cupin_2; pfam07883 630626005031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 630626005032 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 630626005033 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 630626005034 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 630626005035 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 630626005036 NADP binding site [chemical binding]; other site 630626005037 homodimer interface [polypeptide binding]; other site 630626005038 active site 630626005039 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 630626005040 putative inner membrane peptidase; Provisional; Region: PRK11778 630626005041 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 630626005042 tandem repeat interface [polypeptide binding]; other site 630626005043 oligomer interface [polypeptide binding]; other site 630626005044 active site residues [active] 630626005045 hypothetical protein; Provisional; Region: PRK11037 630626005046 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 630626005047 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 630626005048 active site 630626005049 interdomain interaction site; other site 630626005050 putative metal-binding site [ion binding]; other site 630626005051 nucleotide binding site [chemical binding]; other site 630626005052 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 630626005053 domain I; other site 630626005054 DNA binding groove [nucleotide binding] 630626005055 phosphate binding site [ion binding]; other site 630626005056 domain II; other site 630626005057 domain III; other site 630626005058 nucleotide binding site [chemical binding]; other site 630626005059 catalytic site [active] 630626005060 domain IV; other site 630626005061 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 630626005062 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 630626005063 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 630626005064 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 630626005065 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 630626005066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626005067 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 630626005068 substrate binding site [chemical binding]; other site 630626005069 putative dimerization interface [polypeptide binding]; other site 630626005070 aconitate hydratase; Validated; Region: PRK09277 630626005071 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 630626005072 substrate binding site [chemical binding]; other site 630626005073 ligand binding site [chemical binding]; other site 630626005074 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 630626005075 substrate binding site [chemical binding]; other site 630626005076 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 630626005077 dimerization interface [polypeptide binding]; other site 630626005078 active site 630626005079 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 630626005080 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 630626005081 active site 630626005082 Predicted membrane protein [Function unknown]; Region: COG3771 630626005083 tetratricopeptide repeat protein; Provisional; Region: PRK11788 630626005084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626005085 binding surface 630626005086 TPR motif; other site 630626005087 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 630626005088 active site 630626005089 dimer interface [polypeptide binding]; other site 630626005090 translation initiation factor Sui1; Validated; Region: PRK06824 630626005091 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 630626005092 putative rRNA binding site [nucleotide binding]; other site 630626005093 lipoprotein; Provisional; Region: PRK10540 630626005094 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 630626005095 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 630626005096 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 630626005097 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 630626005098 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 630626005099 dimer interface [polypeptide binding]; other site 630626005100 active site 630626005101 glycine loop; other site 630626005102 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 630626005103 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 630626005104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626005105 FeS/SAM binding site; other site 630626005106 Class I aldolases; Region: Aldolase_Class_I; cl17187 630626005107 catalytic residue [active] 630626005108 hypothetical protein; Provisional; Region: PRK13658 630626005109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626005110 PAS domain; Region: PAS_9; pfam13426 630626005111 putative active site [active] 630626005112 heme pocket [chemical binding]; other site 630626005113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626005114 exoribonuclease II; Provisional; Region: PRK05054 630626005115 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 630626005116 RNB domain; Region: RNB; pfam00773 630626005117 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 630626005118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 630626005119 Uncharacterized conserved protein [Function unknown]; Region: COG2128 630626005120 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 630626005121 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 630626005122 NAD binding site [chemical binding]; other site 630626005123 homotetramer interface [polypeptide binding]; other site 630626005124 homodimer interface [polypeptide binding]; other site 630626005125 substrate binding site [chemical binding]; other site 630626005126 active site 630626005127 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 630626005128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005129 Walker A/P-loop; other site 630626005130 ATP binding site [chemical binding]; other site 630626005131 Q-loop/lid; other site 630626005132 ABC transporter signature motif; other site 630626005133 Walker B; other site 630626005134 D-loop; other site 630626005135 H-loop/switch region; other site 630626005136 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 630626005137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005138 Walker A/P-loop; other site 630626005139 ATP binding site [chemical binding]; other site 630626005140 Q-loop/lid; other site 630626005141 ABC transporter signature motif; other site 630626005142 Walker B; other site 630626005143 D-loop; other site 630626005144 H-loop/switch region; other site 630626005145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 630626005146 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 630626005147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005148 dimer interface [polypeptide binding]; other site 630626005149 conserved gate region; other site 630626005150 putative PBP binding loops; other site 630626005151 ABC-ATPase subunit interface; other site 630626005152 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 630626005153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005154 dimer interface [polypeptide binding]; other site 630626005155 conserved gate region; other site 630626005156 putative PBP binding loops; other site 630626005157 ABC-ATPase subunit interface; other site 630626005158 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 630626005159 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 630626005160 peptide binding site [polypeptide binding]; other site 630626005161 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 630626005162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626005163 Walker A motif; other site 630626005164 ATP binding site [chemical binding]; other site 630626005165 Walker B motif; other site 630626005166 arginine finger; other site 630626005167 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 630626005168 phage shock protein PspA; Provisional; Region: PRK10698 630626005169 phage shock protein B; Provisional; Region: pspB; PRK09458 630626005170 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 630626005171 phage shock protein C; Region: phageshock_pspC; TIGR02978 630626005172 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 630626005173 Predicted ATPase [General function prediction only]; Region: COG3106 630626005174 hypothetical protein; Provisional; Region: PRK05415 630626005175 Domain of unknown function (DUF697); Region: DUF697; cl12064 630626005176 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 630626005177 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 630626005178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626005179 putative active site [active] 630626005180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626005181 Walker A motif; other site 630626005182 ATP binding site [chemical binding]; other site 630626005183 Walker B motif; other site 630626005184 arginine finger; other site 630626005185 tyramine oxidase; Provisional; Region: tynA; PRK14696 630626005186 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 630626005187 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 630626005188 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 630626005189 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 630626005190 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 630626005191 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 630626005192 substrate binding site [chemical binding]; other site 630626005193 dimer interface [polypeptide binding]; other site 630626005194 NADP binding site [chemical binding]; other site 630626005195 catalytic residues [active] 630626005196 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 630626005197 substrate binding site [chemical binding]; other site 630626005198 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 630626005199 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 630626005200 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 630626005201 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 630626005202 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 630626005203 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 630626005204 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 630626005205 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 630626005206 FAD binding pocket [chemical binding]; other site 630626005207 FAD binding motif [chemical binding]; other site 630626005208 phosphate binding motif [ion binding]; other site 630626005209 beta-alpha-beta structure motif; other site 630626005210 NAD(p) ribose binding residues [chemical binding]; other site 630626005211 NAD binding pocket [chemical binding]; other site 630626005212 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 630626005213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626005214 catalytic loop [active] 630626005215 iron binding site [ion binding]; other site 630626005216 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 630626005217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626005218 substrate binding site [chemical binding]; other site 630626005219 oxyanion hole (OAH) forming residues; other site 630626005220 trimer interface [polypeptide binding]; other site 630626005221 enoyl-CoA hydratase; Provisional; Region: PRK08140 630626005222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626005223 substrate binding site [chemical binding]; other site 630626005224 oxyanion hole (OAH) forming residues; other site 630626005225 trimer interface [polypeptide binding]; other site 630626005226 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 630626005227 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 630626005228 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626005229 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626005230 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 630626005231 CoenzymeA binding site [chemical binding]; other site 630626005232 subunit interaction site [polypeptide binding]; other site 630626005233 PHB binding site; other site 630626005234 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 630626005235 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626005236 dimer interface [polypeptide binding]; other site 630626005237 active site 630626005238 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 630626005239 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 630626005240 active site 630626005241 AMP binding site [chemical binding]; other site 630626005242 homodimer interface [polypeptide binding]; other site 630626005243 acyl-activating enzyme (AAE) consensus motif; other site 630626005244 CoA binding site [chemical binding]; other site 630626005245 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 630626005246 FAD binding domain; Region: FAD_binding_4; pfam01565 630626005247 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 630626005248 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 630626005249 CoenzymeA binding site [chemical binding]; other site 630626005250 subunit interaction site [polypeptide binding]; other site 630626005251 PHB binding site; other site 630626005252 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 630626005253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626005254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626005255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626005256 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 630626005257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626005258 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 630626005259 putative ADP-binding pocket [chemical binding]; other site 630626005260 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 630626005261 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 630626005262 putative ABC transporter; Region: ycf24; CHL00085 630626005263 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 630626005264 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 630626005265 Walker A/P-loop; other site 630626005266 ATP binding site [chemical binding]; other site 630626005267 Q-loop/lid; other site 630626005268 ABC transporter signature motif; other site 630626005269 Walker B; other site 630626005270 D-loop; other site 630626005271 H-loop/switch region; other site 630626005272 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 630626005273 FeS assembly protein SufD; Region: sufD; TIGR01981 630626005274 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 630626005275 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 630626005276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626005277 catalytic residue [active] 630626005278 cysteine desufuration protein SufE; Provisional; Region: PRK09296 630626005279 L,D-transpeptidase; Provisional; Region: PRK10190 630626005280 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 630626005281 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626005282 murein lipoprotein; Provisional; Region: PRK15396 630626005283 pyruvate kinase; Provisional; Region: PRK09206 630626005284 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 630626005285 domain interfaces; other site 630626005286 active site 630626005287 GlpM protein; Region: GlpM; pfam06942 630626005288 YdfZ protein; Region: YdfZ; cl11878 630626005289 hypothetical protein; Provisional; Region: PRK11019 630626005290 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626005291 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626005292 metal binding site [ion binding]; metal-binding site 630626005293 active site 630626005294 I-site; other site 630626005295 glycogen debranching enzyme; Provisional; Region: PRK03705 630626005296 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 630626005297 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 630626005298 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 630626005299 MarB protein; Region: MarB; cl08087 630626005300 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 630626005301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626005302 MarR family; Region: MarR_2; cl17246 630626005303 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626005304 putative arabinose transporter; Provisional; Region: PRK03545 630626005305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005306 putative substrate translocation pore; other site 630626005307 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 630626005308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626005309 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 630626005310 putative dimerization interface [polypeptide binding]; other site 630626005311 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 630626005312 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 630626005313 NAD(P) binding site [chemical binding]; other site 630626005314 catalytic residues [active] 630626005315 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 630626005316 glutaminase; Provisional; Region: PRK00971 630626005317 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 630626005318 Protein of unknown function (DUF535); Region: DUF535; pfam04393 630626005319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626005320 DNA-binding site [nucleotide binding]; DNA binding site 630626005321 Transcriptional regulators [Transcription]; Region: GntR; COG1802 630626005322 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626005323 altronate oxidoreductase; Provisional; Region: PRK03643 630626005324 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 630626005325 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 630626005326 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 630626005327 haemagglutination activity domain; Region: Haemagg_act; pfam05860 630626005328 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 630626005329 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626005330 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626005331 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 630626005332 HTH-like domain; Region: HTH_21; pfam13276 630626005333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626005334 Integrase core domain; Region: rve; pfam00665 630626005335 Integrase core domain; Region: rve_3; pfam13683 630626005336 Transposase; Region: HTH_Tnp_1; pfam01527 630626005337 HTH-like domain; Region: HTH_21; pfam13276 630626005338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626005339 Integrase core domain; Region: rve; pfam00665 630626005340 Integrase core domain; Region: rve_3; pfam13683 630626005341 Transposase; Region: HTH_Tnp_1; pfam01527 630626005342 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 630626005343 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 630626005344 CopC domain; Region: CopC; pfam04234 630626005345 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 630626005346 ecotin; Provisional; Region: PRK03719 630626005347 secondary substrate binding site; other site 630626005348 primary substrate binding site; other site 630626005349 inhibition loop; other site 630626005350 dimerization interface [polypeptide binding]; other site 630626005351 NMT1/THI5 like; Region: NMT1; pfam09084 630626005352 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 630626005353 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 630626005354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005355 dimer interface [polypeptide binding]; other site 630626005356 conserved gate region; other site 630626005357 putative PBP binding loops; other site 630626005358 ABC-ATPase subunit interface; other site 630626005359 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 630626005360 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 630626005361 Walker A/P-loop; other site 630626005362 ATP binding site [chemical binding]; other site 630626005363 Q-loop/lid; other site 630626005364 ABC transporter signature motif; other site 630626005365 Walker B; other site 630626005366 D-loop; other site 630626005367 H-loop/switch region; other site 630626005368 Putative transcription activator [Transcription]; Region: TenA; COG0819 630626005369 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626005370 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626005371 dimer interface [polypeptide binding]; other site 630626005372 putative PBP binding regions; other site 630626005373 ABC-ATPase subunit interface; other site 630626005374 Methyltransferase domain; Region: Methyltransf_31; pfam13847 630626005375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626005376 S-adenosylmethionine binding site [chemical binding]; other site 630626005377 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 630626005378 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 630626005379 intersubunit interface [polypeptide binding]; other site 630626005380 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 630626005381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626005382 N-terminal plug; other site 630626005383 ligand-binding site [chemical binding]; other site 630626005384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 630626005385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 630626005386 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 630626005387 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 630626005388 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 630626005389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626005390 S-adenosylmethionine binding site [chemical binding]; other site 630626005391 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 630626005392 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 630626005393 mce related protein; Region: MCE; pfam02470 630626005394 mce related protein; Region: MCE; pfam02470 630626005395 mce related protein; Region: MCE; pfam02470 630626005396 mce related protein; Region: MCE; pfam02470 630626005397 mce related protein; Region: MCE; pfam02470 630626005398 mce related protein; Region: MCE; pfam02470 630626005399 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 630626005400 Paraquat-inducible protein A; Region: PqiA; pfam04403 630626005401 Paraquat-inducible protein A; Region: PqiA; pfam04403 630626005402 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 630626005403 GAF domain; Region: GAF_2; pfam13185 630626005404 ProP expression regulator; Provisional; Region: PRK04950 630626005405 ProQ/FINO family; Region: ProQ; pfam04352 630626005406 carboxy-terminal protease; Provisional; Region: PRK11186 630626005407 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 630626005408 protein binding site [polypeptide binding]; other site 630626005409 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 630626005410 Catalytic dyad [active] 630626005411 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 630626005412 heat shock protein HtpX; Provisional; Region: PRK05457 630626005413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626005415 putative substrate translocation pore; other site 630626005416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005417 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 630626005418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626005419 dimerization interface [polypeptide binding]; other site 630626005420 putative Zn2+ binding site [ion binding]; other site 630626005421 putative DNA binding site [nucleotide binding]; other site 630626005422 Bacterial transcriptional regulator; Region: IclR; pfam01614 630626005423 YobH-like protein; Region: YobH; pfam13996 630626005424 YebO-like protein; Region: YebO; pfam13974 630626005425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626005426 DNA-binding site [nucleotide binding]; DNA binding site 630626005427 RNA-binding motif; other site 630626005428 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 630626005429 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 630626005430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 630626005431 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 630626005432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626005433 S-adenosylmethionine binding site [chemical binding]; other site 630626005434 hypothetical protein; Provisional; Region: PRK11469 630626005435 Domain of unknown function DUF; Region: DUF204; pfam02659 630626005436 Domain of unknown function DUF; Region: DUF204; pfam02659 630626005437 hypothetical protein; Provisional; Region: PRK02913 630626005438 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 630626005439 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 630626005440 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 630626005441 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 630626005442 active pocket/dimerization site; other site 630626005443 active site 630626005444 phosphorylation site [posttranslational modification] 630626005445 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 630626005446 active site 630626005447 phosphorylation site [posttranslational modification] 630626005448 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 630626005449 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 630626005450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 630626005451 Transporter associated domain; Region: CorC_HlyC; smart01091 630626005452 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 630626005453 CPxP motif; other site 630626005454 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 630626005455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 630626005456 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 630626005457 putative dimer interface [polypeptide binding]; other site 630626005458 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 630626005459 NAD binding site [chemical binding]; other site 630626005460 nucleoside transporter; Region: 2A0110; TIGR00889 630626005461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626005462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626005463 DNA binding site [nucleotide binding] 630626005464 domain linker motif; other site 630626005465 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 630626005466 dimerization interface [polypeptide binding]; other site 630626005467 ligand binding site [chemical binding]; other site 630626005468 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 630626005469 active site 630626005470 tetramer interface [polypeptide binding]; other site 630626005471 L-serine deaminase; Provisional; Region: PRK15023 630626005472 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 630626005473 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 630626005474 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 630626005475 putative active site [active] 630626005476 putative CoA binding site [chemical binding]; other site 630626005477 nudix motif; other site 630626005478 metal binding site [ion binding]; metal-binding site 630626005479 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 630626005480 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 630626005481 chorismate binding enzyme; Region: Chorismate_bind; cl10555 630626005482 hypothetical protein; Provisional; Region: PRK05114 630626005483 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 630626005484 homotrimer interaction site [polypeptide binding]; other site 630626005485 putative active site [active] 630626005486 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 630626005487 DEAD/DEAH box helicase; Region: DEAD; pfam00270 630626005488 DEAD_2; Region: DEAD_2; pfam06733 630626005489 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 630626005490 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 630626005491 Glycoprotease family; Region: Peptidase_M22; pfam00814 630626005492 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 630626005493 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 630626005494 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 630626005495 acyl-activating enzyme (AAE) consensus motif; other site 630626005496 putative AMP binding site [chemical binding]; other site 630626005497 putative active site [active] 630626005498 putative CoA binding site [chemical binding]; other site 630626005499 ribonuclease D; Provisional; Region: PRK10829 630626005500 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 630626005501 catalytic site [active] 630626005502 putative active site [active] 630626005503 putative substrate binding site [chemical binding]; other site 630626005504 Helicase and RNase D C-terminal; Region: HRDC; smart00341 630626005505 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 630626005506 cell division inhibitor MinD; Provisional; Region: PRK10818 630626005507 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 630626005508 Switch I; other site 630626005509 Switch II; other site 630626005510 septum formation inhibitor; Reviewed; Region: minC; PRK03511 630626005511 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 630626005512 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 630626005513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 630626005514 hypothetical protein; Provisional; Region: PRK10691 630626005515 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 630626005516 hypothetical protein; Provisional; Region: PRK05170 630626005517 disulfide bond formation protein B; Provisional; Region: PRK01749 630626005518 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 630626005519 transmembrane helices; other site 630626005520 fatty acid metabolism regulator; Provisional; Region: PRK04984 630626005521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626005522 DNA-binding site [nucleotide binding]; DNA binding site 630626005523 FadR C-terminal domain; Region: FadR_C; pfam07840 630626005524 SpoVR family protein; Provisional; Region: PRK11767 630626005525 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 630626005526 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 630626005527 hydroxyglutarate oxidase; Provisional; Region: PRK11728 630626005528 alanine racemase; Reviewed; Region: dadX; PRK03646 630626005529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 630626005530 active site 630626005531 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626005532 substrate binding site [chemical binding]; other site 630626005533 catalytic residues [active] 630626005534 dimer interface [polypeptide binding]; other site 630626005535 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 630626005536 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 630626005537 TrkA-C domain; Region: TrkA_C; pfam02080 630626005538 Transporter associated domain; Region: CorC_HlyC; smart01091 630626005539 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 630626005540 dimer interface [polypeptide binding]; other site 630626005541 catalytic triad [active] 630626005542 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 630626005543 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626005544 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626005545 catalytic residue [active] 630626005546 hypothetical protein; Provisional; Region: PRK10457 630626005547 hypothetical protein; Provisional; Region: PRK12378 630626005548 Protein of unknown function, DUF606; Region: DUF606; pfam04657 630626005549 Protein of unknown function, DUF606; Region: DUF606; pfam04657 630626005550 Protein of unknown function, DUF606; Region: DUF606; pfam04657 630626005551 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 630626005552 HTH-like domain; Region: HTH_21; pfam13276 630626005553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626005554 Integrase core domain; Region: rve; pfam00665 630626005555 Integrase core domain; Region: rve_3; pfam13683 630626005556 Trehalase; Region: Trehalase; cl17346 630626005557 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 630626005558 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 630626005559 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 630626005560 PapC C-terminal domain; Region: PapC_C; pfam13953 630626005561 Fimbrial protein; Region: Fimbrial; cl01416 630626005562 Fimbrial protein; Region: Fimbrial; cl01416 630626005563 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 630626005564 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 630626005565 Bacterial transcriptional regulator; Region: IclR; pfam01614 630626005566 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 630626005567 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 630626005568 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 630626005569 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626005570 dimer interface [polypeptide binding]; other site 630626005571 active site 630626005572 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 630626005573 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 630626005574 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 630626005575 octamer interface [polypeptide binding]; other site 630626005576 active site 630626005577 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 630626005578 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 630626005579 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 630626005580 dimer interface [polypeptide binding]; other site 630626005581 active site 630626005582 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 630626005583 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 630626005584 iron-sulfur cluster [ion binding]; other site 630626005585 [2Fe-2S] cluster binding site [ion binding]; other site 630626005586 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 630626005587 putative alpha subunit interface [polypeptide binding]; other site 630626005588 putative active site [active] 630626005589 putative substrate binding site [chemical binding]; other site 630626005590 Fe binding site [ion binding]; other site 630626005591 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 630626005592 inter-subunit interface; other site 630626005593 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 630626005594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626005595 catalytic loop [active] 630626005596 iron binding site [ion binding]; other site 630626005597 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 630626005598 FAD binding pocket [chemical binding]; other site 630626005599 FAD binding motif [chemical binding]; other site 630626005600 phosphate binding motif [ion binding]; other site 630626005601 beta-alpha-beta structure motif; other site 630626005602 NAD binding pocket [chemical binding]; other site 630626005603 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 630626005604 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 630626005605 putative NAD(P) binding site [chemical binding]; other site 630626005606 active site 630626005607 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 630626005608 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 630626005609 CHAP domain; Region: CHAP; pfam05257 630626005610 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 630626005611 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 630626005612 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 630626005613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 630626005614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626005615 DNA-binding site [nucleotide binding]; DNA binding site 630626005616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626005617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626005618 homodimer interface [polypeptide binding]; other site 630626005619 catalytic residue [active] 630626005620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 630626005621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 630626005622 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 630626005623 Predicted membrane protein [Function unknown]; Region: COG4125 630626005624 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 630626005625 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 630626005626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626005627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626005628 LysR substrate binding domain; Region: LysR_substrate; pfam03466 630626005629 dimerization interface [polypeptide binding]; other site 630626005630 outer membrane protease; Reviewed; Region: PRK10993 630626005631 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 630626005632 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 630626005633 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 630626005634 putative substrate-binding site; other site 630626005635 nickel binding site [ion binding]; other site 630626005636 hydrogenase 2 large subunit; Provisional; Region: PRK10467 630626005637 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 630626005638 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 630626005639 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 630626005640 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 630626005641 4Fe-4S binding domain; Region: Fer4; cl02805 630626005642 hydrogenase 2 small subunit; Provisional; Region: PRK10468 630626005643 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 630626005644 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 630626005645 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 630626005646 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 630626005647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 630626005648 metal-binding site [ion binding] 630626005649 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 630626005650 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 630626005651 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 630626005652 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 630626005653 substrate binding site [chemical binding]; other site 630626005654 nickel transporter permease NikB; Provisional; Region: PRK10352 630626005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005656 dimer interface [polypeptide binding]; other site 630626005657 conserved gate region; other site 630626005658 putative PBP binding loops; other site 630626005659 ABC-ATPase subunit interface; other site 630626005660 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 630626005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005662 dimer interface [polypeptide binding]; other site 630626005663 conserved gate region; other site 630626005664 putative PBP binding loops; other site 630626005665 ABC-ATPase subunit interface; other site 630626005666 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 630626005667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005668 Walker A/P-loop; other site 630626005669 ATP binding site [chemical binding]; other site 630626005670 Q-loop/lid; other site 630626005671 ABC transporter signature motif; other site 630626005672 Walker B; other site 630626005673 D-loop; other site 630626005674 H-loop/switch region; other site 630626005675 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 630626005676 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 630626005677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005678 Walker A/P-loop; other site 630626005679 ATP binding site [chemical binding]; other site 630626005680 Q-loop/lid; other site 630626005681 ABC transporter signature motif; other site 630626005682 Walker B; other site 630626005683 D-loop; other site 630626005684 H-loop/switch region; other site 630626005685 nickel responsive regulator; Provisional; Region: PRK02967 630626005686 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 630626005687 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 630626005688 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 630626005689 putative ligand binding site [chemical binding]; other site 630626005690 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626005691 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 630626005692 TM-ABC transporter signature motif; other site 630626005693 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 630626005694 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 630626005695 TM-ABC transporter signature motif; other site 630626005696 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 630626005697 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 630626005698 Walker A/P-loop; other site 630626005699 ATP binding site [chemical binding]; other site 630626005700 Q-loop/lid; other site 630626005701 ABC transporter signature motif; other site 630626005702 Walker B; other site 630626005703 D-loop; other site 630626005704 H-loop/switch region; other site 630626005705 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 630626005706 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 630626005707 Walker A/P-loop; other site 630626005708 ATP binding site [chemical binding]; other site 630626005709 Q-loop/lid; other site 630626005710 ABC transporter signature motif; other site 630626005711 Walker B; other site 630626005712 D-loop; other site 630626005713 H-loop/switch region; other site 630626005714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005715 D-galactonate transporter; Region: 2A0114; TIGR00893 630626005716 putative substrate translocation pore; other site 630626005717 Haem-binding domain; Region: Haem_bd; pfam14376 630626005718 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 630626005719 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 630626005720 trimer interface [polypeptide binding]; other site 630626005721 active site 630626005722 substrate binding site [chemical binding]; other site 630626005723 CoA binding site [chemical binding]; other site 630626005724 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 630626005725 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626005726 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 630626005727 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 630626005728 NADP binding site [chemical binding]; other site 630626005729 dimer interface [polypeptide binding]; other site 630626005730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626005731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626005732 HTH-like domain; Region: HTH_21; pfam13276 630626005733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626005734 Integrase core domain; Region: rve; pfam00665 630626005735 Integrase core domain; Region: rve_3; pfam13683 630626005736 Transposase; Region: HTH_Tnp_1; pfam01527 630626005737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626005738 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 630626005739 Walker A motif; other site 630626005740 ATP binding site [chemical binding]; other site 630626005741 Walker B motif; other site 630626005742 arginine finger; other site 630626005743 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 630626005744 HTH-like domain; Region: HTH_21; pfam13276 630626005745 Integrase core domain; Region: rve; pfam00665 630626005746 Integrase core domain; Region: rve_3; pfam13683 630626005747 Transposase; Region: HTH_Tnp_1; cl17663 630626005748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626005749 Predicted transcriptional regulator [Transcription]; Region: COG2378 630626005750 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 630626005751 WYL domain; Region: WYL; pfam13280 630626005752 Integrase core domain; Region: rve; pfam00665 630626005753 Integrase core domain; Region: rve_2; pfam13333 630626005754 GTP-binding protein YchF; Reviewed; Region: PRK09601 630626005755 YchF GTPase; Region: YchF; cd01900 630626005756 G1 box; other site 630626005757 GTP/Mg2+ binding site [chemical binding]; other site 630626005758 Switch I region; other site 630626005759 G2 box; other site 630626005760 Switch II region; other site 630626005761 G3 box; other site 630626005762 G4 box; other site 630626005763 G5 box; other site 630626005764 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 630626005765 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 630626005766 putative active site [active] 630626005767 catalytic residue [active] 630626005768 hypothetical protein; Provisional; Region: PRK10692 630626005769 putative transporter; Provisional; Region: PRK11660 630626005770 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 630626005771 Sulfate transporter family; Region: Sulfate_transp; pfam00916 630626005772 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 630626005773 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 630626005774 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 630626005775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626005776 active site 630626005777 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 630626005778 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 630626005779 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 630626005780 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 630626005781 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 630626005782 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 630626005783 tRNA; other site 630626005784 putative tRNA binding site [nucleotide binding]; other site 630626005785 putative NADP binding site [chemical binding]; other site 630626005786 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 630626005787 peptide chain release factor 1; Validated; Region: prfA; PRK00591 630626005788 This domain is found in peptide chain release factors; Region: PCRF; smart00937 630626005789 RF-1 domain; Region: RF-1; pfam00472 630626005790 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 630626005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626005792 hypothetical protein; Provisional; Region: PRK10941 630626005793 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 630626005794 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 630626005795 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 630626005796 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 630626005797 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 630626005798 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 630626005799 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 630626005800 putative active site pocket [active] 630626005801 dimerization interface [polypeptide binding]; other site 630626005802 putative catalytic residue [active] 630626005803 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 630626005804 putative invasin; Provisional; Region: PRK10177 630626005805 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 630626005806 transcriptional regulator NarL; Provisional; Region: PRK10651 630626005807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626005808 active site 630626005809 phosphorylation site [posttranslational modification] 630626005810 intermolecular recognition site; other site 630626005811 dimerization interface [polypeptide binding]; other site 630626005812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626005813 DNA binding residues [nucleotide binding] 630626005814 dimerization interface [polypeptide binding]; other site 630626005815 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 630626005816 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 630626005817 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 630626005818 dimerization interface [polypeptide binding]; other site 630626005819 Histidine kinase; Region: HisKA_3; pfam07730 630626005820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626005821 ATP binding site [chemical binding]; other site 630626005822 Mg2+ binding site [ion binding]; other site 630626005823 G-X-G motif; other site 630626005824 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 630626005825 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 630626005826 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 630626005827 [4Fe-4S] binding site [ion binding]; other site 630626005828 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626005829 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626005830 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626005831 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 630626005832 molybdopterin cofactor binding site; other site 630626005833 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 630626005834 4Fe-4S binding domain; Region: Fer4; cl02805 630626005835 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 630626005836 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 630626005837 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 630626005838 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 630626005839 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 630626005840 putative active site [active] 630626005841 putative substrate binding site [chemical binding]; other site 630626005842 putative cosubstrate binding site; other site 630626005843 catalytic site [active] 630626005844 SEC-C motif; Region: SEC-C; pfam02810 630626005845 hypothetical protein; Provisional; Region: PRK04233 630626005846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626005847 active site 630626005848 response regulator of RpoS; Provisional; Region: PRK10693 630626005849 phosphorylation site [posttranslational modification] 630626005850 intermolecular recognition site; other site 630626005851 dimerization interface [polypeptide binding]; other site 630626005852 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 630626005853 active site 630626005854 tetramer interface; other site 630626005855 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 630626005856 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 630626005857 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 630626005858 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 630626005859 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 630626005860 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 630626005861 thymidine kinase; Provisional; Region: PRK04296 630626005862 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 630626005863 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 630626005864 putative catalytic cysteine [active] 630626005865 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 630626005866 putative active site [active] 630626005867 metal binding site [ion binding]; metal-binding site 630626005868 hypothetical protein; Provisional; Region: PRK11111 630626005869 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 630626005870 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 630626005871 peptide binding site [polypeptide binding]; other site 630626005872 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 630626005873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005874 dimer interface [polypeptide binding]; other site 630626005875 conserved gate region; other site 630626005876 putative PBP binding loops; other site 630626005877 ABC-ATPase subunit interface; other site 630626005878 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 630626005879 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 630626005880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005881 dimer interface [polypeptide binding]; other site 630626005882 conserved gate region; other site 630626005883 ABC-ATPase subunit interface; other site 630626005884 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 630626005885 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005886 Walker A/P-loop; other site 630626005887 ATP binding site [chemical binding]; other site 630626005888 Q-loop/lid; other site 630626005889 ABC transporter signature motif; other site 630626005890 Walker B; other site 630626005891 D-loop; other site 630626005892 H-loop/switch region; other site 630626005893 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 630626005894 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 630626005895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626005896 Walker A/P-loop; other site 630626005897 ATP binding site [chemical binding]; other site 630626005898 Q-loop/lid; other site 630626005899 ABC transporter signature motif; other site 630626005900 Walker B; other site 630626005901 D-loop; other site 630626005902 H-loop/switch region; other site 630626005903 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 630626005904 Ion transport protein; Region: Ion_trans; pfam00520 630626005905 Ion channel; Region: Ion_trans_2; pfam07885 630626005906 dsDNA-mimic protein; Reviewed; Region: PRK05094 630626005907 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 630626005908 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 630626005909 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 630626005910 putative active site [active] 630626005911 catalytic site [active] 630626005912 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 630626005913 putative active site [active] 630626005914 catalytic site [active] 630626005915 YciI-like protein; Reviewed; Region: PRK11370 630626005916 transport protein TonB; Provisional; Region: PRK10819 630626005917 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 630626005918 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 630626005919 intracellular septation protein A; Reviewed; Region: PRK00259 630626005920 hypothetical protein; Provisional; Region: PRK02868 630626005921 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 630626005922 outer membrane protein W; Provisional; Region: PRK10959 630626005923 DinI-like family; Region: DinI; pfam06183 630626005924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626005925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626005926 metal binding site [ion binding]; metal-binding site 630626005927 active site 630626005928 I-site; other site 630626005929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626005930 dimer interface [polypeptide binding]; other site 630626005931 conserved gate region; other site 630626005932 ABC-ATPase subunit interface; other site 630626005933 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 630626005934 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 630626005935 Walker A/P-loop; other site 630626005936 ATP binding site [chemical binding]; other site 630626005937 Q-loop/lid; other site 630626005938 ABC transporter signature motif; other site 630626005939 Walker B; other site 630626005940 D-loop; other site 630626005941 H-loop/switch region; other site 630626005942 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 630626005943 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 630626005944 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 630626005945 active site 630626005946 non-prolyl cis peptide bond; other site 630626005947 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 630626005948 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 630626005949 active site 630626005950 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 630626005951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 630626005952 active site 630626005953 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 630626005954 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 630626005955 putative NAD(P) binding site [chemical binding]; other site 630626005956 putative substrate binding site [chemical binding]; other site 630626005957 catalytic Zn binding site [ion binding]; other site 630626005958 structural Zn binding site [ion binding]; other site 630626005959 dimer interface [polypeptide binding]; other site 630626005960 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 630626005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626005962 active site 630626005963 phosphorylation site [posttranslational modification] 630626005964 intermolecular recognition site; other site 630626005965 dimerization interface [polypeptide binding]; other site 630626005966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626005967 DNA binding residues [nucleotide binding] 630626005968 dimerization interface [polypeptide binding]; other site 630626005969 Domain of unknown function (DUF336); Region: DUF336; pfam03928 630626005970 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 630626005971 Protein of unknown function (DUF419); Region: DUF419; cl15265 630626005972 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 630626005973 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 630626005974 NAD(P) binding site [chemical binding]; other site 630626005975 catalytic residues [active] 630626005976 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 630626005977 DctM-like transporters; Region: DctM; pfam06808 630626005978 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 630626005979 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 630626005980 putative monooxygenase; Provisional; Region: PRK11118 630626005981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626005982 transcriptional regulator protein; Region: phnR; TIGR03337 630626005983 DNA-binding site [nucleotide binding]; DNA binding site 630626005984 UTRA domain; Region: UTRA; pfam07702 630626005985 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 630626005986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626005987 putative substrate translocation pore; other site 630626005988 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 630626005989 malate dehydrogenase; Provisional; Region: PRK13529 630626005990 Malic enzyme, N-terminal domain; Region: malic; pfam00390 630626005991 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 630626005992 NAD(P) binding site [chemical binding]; other site 630626005993 aspartate kinase III; Validated; Region: PRK09084 630626005994 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 630626005995 nucleotide binding site [chemical binding]; other site 630626005996 substrate binding site [chemical binding]; other site 630626005997 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 630626005998 lysine allosteric regulatory site; other site 630626005999 dimer interface [polypeptide binding]; other site 630626006000 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 630626006001 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 630626006002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626006003 inhibitor-cofactor binding pocket; inhibition site 630626006004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626006005 catalytic residue [active] 630626006006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 630626006007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626006008 catalytic residue [active] 630626006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 630626006010 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 630626006011 SdiA-regulated; Region: SdiA-regulated; cd09971 630626006012 SdiA-regulated; Region: SdiA-regulated; pfam06977 630626006013 putative active site [active] 630626006014 Predicted membrane protein [Function unknown]; Region: COG3326 630626006015 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 630626006016 putative catalytic site [active] 630626006017 putative metal binding site [ion binding]; other site 630626006018 putative phosphate binding site [ion binding]; other site 630626006019 HipA N-terminal domain; Region: Couple_hipA; cl11853 630626006020 HipA-like N-terminal domain; Region: HipA_N; pfam07805 630626006021 HipA-like C-terminal domain; Region: HipA_C; pfam07804 630626006022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626006023 non-specific DNA binding site [nucleotide binding]; other site 630626006024 salt bridge; other site 630626006025 sequence-specific DNA binding site [nucleotide binding]; other site 630626006026 Domain of unknown function (DUF386); Region: DUF386; cl01047 630626006027 N-acetylmannosamine kinase; Provisional; Region: PRK05082 630626006028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626006029 nucleotide binding site [chemical binding]; other site 630626006030 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 630626006031 active site 630626006032 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 630626006033 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 630626006034 putative active site cavity [active] 630626006035 putative sialic acid transporter; Provisional; Region: PRK03893 630626006036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006037 putative substrate translocation pore; other site 630626006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006039 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 630626006040 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626006041 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626006042 putative active site [active] 630626006043 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 630626006044 Class I aldolases; Region: Aldolase_Class_I; cl17187 630626006045 catalytic residue [active] 630626006046 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 630626006047 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626006048 LysR family transcriptional regulator; Provisional; Region: PRK14997 630626006049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006050 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 630626006051 putative effector binding pocket; other site 630626006052 putative dimerization interface [polypeptide binding]; other site 630626006053 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 630626006054 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626006055 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 630626006056 Predicted membrane protein [Function unknown]; Region: COG2259 630626006057 Protein of unknown function (DUF465); Region: DUF465; cl01070 630626006058 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 630626006059 nudix motif; other site 630626006060 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 630626006061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 630626006062 NAD(P) binding site [chemical binding]; other site 630626006063 catalytic residues [active] 630626006064 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 630626006065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626006066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 630626006067 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 630626006068 hypothetical protein; Provisional; Region: PRK10695 630626006069 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 630626006070 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 630626006071 putative ligand binding site [chemical binding]; other site 630626006072 putative NAD binding site [chemical binding]; other site 630626006073 catalytic site [active] 630626006074 META domain; Region: META; cl01245 630626006075 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 630626006076 Domain of unknown function (DUF333); Region: DUF333; pfam03891 630626006077 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 630626006078 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 630626006079 dimer interface [polypeptide binding]; other site 630626006080 PYR/PP interface [polypeptide binding]; other site 630626006081 TPP binding site [chemical binding]; other site 630626006082 substrate binding site [chemical binding]; other site 630626006083 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 630626006084 Domain of unknown function; Region: EKR; smart00890 630626006085 4Fe-4S binding domain; Region: Fer4_6; pfam12837 630626006086 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626006087 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 630626006088 TPP-binding site [chemical binding]; other site 630626006089 dimer interface [polypeptide binding]; other site 630626006090 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 630626006091 active site 630626006092 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 630626006093 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 630626006094 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 630626006095 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 630626006096 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 630626006097 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 630626006098 Cytochrome c; Region: Cytochrom_C; pfam00034 630626006099 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 630626006100 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 630626006101 Ligand Binding Site [chemical binding]; other site 630626006102 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 630626006103 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 630626006104 ATP binding site [chemical binding]; other site 630626006105 Mg++ binding site [ion binding]; other site 630626006106 motif III; other site 630626006107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626006108 nucleotide binding region [chemical binding]; other site 630626006109 ATP-binding site [chemical binding]; other site 630626006110 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 630626006111 putative RNA binding site [nucleotide binding]; other site 630626006112 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 630626006113 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 630626006114 Cl binding site [ion binding]; other site 630626006115 oligomer interface [polypeptide binding]; other site 630626006116 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 630626006117 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 630626006118 peptide binding site [polypeptide binding]; other site 630626006119 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 630626006120 putative active site [active] 630626006121 Zn binding site [ion binding]; other site 630626006122 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 630626006123 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 630626006124 active site 630626006125 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 630626006126 dimer interface [polypeptide binding]; other site 630626006127 catalytic triad [active] 630626006128 peroxidatic and resolving cysteines [active] 630626006129 PQQ-like domain; Region: PQQ_2; pfam13360 630626006130 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 630626006131 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 630626006132 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 630626006133 [4Fe-4S] binding site [ion binding]; other site 630626006134 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626006135 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626006136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626006137 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 630626006138 molybdopterin cofactor binding site; other site 630626006139 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 630626006140 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 630626006141 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 630626006142 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 630626006143 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 630626006144 active site 630626006145 catalytic residues [active] 630626006146 metal binding site [ion binding]; metal-binding site 630626006147 DmpG-like communication domain; Region: DmpG_comm; pfam07836 630626006148 acetaldehyde dehydrogenase; Validated; Region: PRK08300 630626006149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 630626006150 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 630626006151 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 630626006152 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 630626006153 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 630626006154 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 630626006155 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 630626006156 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 630626006157 putative active site [active] 630626006158 Fe(II) binding site [ion binding]; other site 630626006159 putative dimer interface [polypeptide binding]; other site 630626006160 putative tetramer interface [polypeptide binding]; other site 630626006161 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 630626006162 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626006163 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 630626006164 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 630626006165 Bacterial transcriptional regulator; Region: IclR; pfam01614 630626006166 N-acetyltransferase; Region: Acetyltransf_2; cl00949 630626006167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 630626006168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626006169 non-specific DNA binding site [nucleotide binding]; other site 630626006170 salt bridge; other site 630626006171 sequence-specific DNA binding site [nucleotide binding]; other site 630626006172 Cupin domain; Region: Cupin_2; pfam07883 630626006173 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 630626006174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626006175 Coenzyme A binding pocket [chemical binding]; other site 630626006176 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 630626006177 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 630626006178 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626006179 Protein of unknown function (DUF2767); Region: DUF2767; cl08104 630626006180 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 630626006181 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 630626006182 tetrameric interface [polypeptide binding]; other site 630626006183 NAD binding site [chemical binding]; other site 630626006184 catalytic residues [active] 630626006185 substrate binding site [chemical binding]; other site 630626006186 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 630626006187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626006188 putative PBP binding loops; other site 630626006189 dimer interface [polypeptide binding]; other site 630626006190 ABC-ATPase subunit interface; other site 630626006191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626006192 dimer interface [polypeptide binding]; other site 630626006193 conserved gate region; other site 630626006194 putative PBP binding loops; other site 630626006195 ABC-ATPase subunit interface; other site 630626006196 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 630626006197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626006198 Walker A/P-loop; other site 630626006199 ATP binding site [chemical binding]; other site 630626006200 Q-loop/lid; other site 630626006201 ABC transporter signature motif; other site 630626006202 Walker B; other site 630626006203 D-loop; other site 630626006204 H-loop/switch region; other site 630626006205 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 630626006206 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 630626006207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 630626006208 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 630626006209 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 630626006210 Tetratricopeptide repeat; Region: TPR_16; pfam13432 630626006211 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 630626006212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626006213 active site 630626006214 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 630626006215 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 630626006216 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 630626006217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 630626006218 Peptidase family U32; Region: Peptidase_U32; pfam01136 630626006219 Collagenase; Region: DUF3656; pfam12392 630626006220 tellurite resistance protein TehB; Provisional; Region: PRK11207 630626006221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626006222 S-adenosylmethionine binding site [chemical binding]; other site 630626006223 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 630626006224 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 630626006225 gating phenylalanine in ion channel; other site 630626006226 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 630626006227 putative trimer interface [polypeptide binding]; other site 630626006228 putative CoA binding site [chemical binding]; other site 630626006229 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 630626006230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626006231 Coenzyme A binding pocket [chemical binding]; other site 630626006232 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 630626006233 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 630626006234 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 630626006235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 630626006236 substrate binding pocket [chemical binding]; other site 630626006237 catalytic triad [active] 630626006238 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 630626006239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 630626006240 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 630626006241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006242 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 630626006243 putative dimerization interface [polypeptide binding]; other site 630626006244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626006245 PAS domain; Region: PAS_9; pfam13426 630626006246 putative active site [active] 630626006247 heme pocket [chemical binding]; other site 630626006248 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626006249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626006250 metal binding site [ion binding]; metal-binding site 630626006251 active site 630626006252 I-site; other site 630626006253 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626006254 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 630626006255 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 630626006256 substrate binding site [chemical binding]; other site 630626006257 catalytic Zn binding site [ion binding]; other site 630626006258 NAD binding site [chemical binding]; other site 630626006259 structural Zn binding site [ion binding]; other site 630626006260 dimer interface [polypeptide binding]; other site 630626006261 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 630626006262 putative metal binding site [ion binding]; other site 630626006263 putative homodimer interface [polypeptide binding]; other site 630626006264 putative homotetramer interface [polypeptide binding]; other site 630626006265 putative homodimer-homodimer interface [polypeptide binding]; other site 630626006266 putative allosteric switch controlling residues; other site 630626006267 Phage-related protein, tail component [Function unknown]; Region: COG4733 630626006268 Putative phage tail protein; Region: Phage-tail_3; pfam13550 630626006269 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 630626006270 Interdomain contacts; other site 630626006271 Cytokine receptor motif; other site 630626006272 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 630626006273 Phage-related protein, tail component [Function unknown]; Region: COG4723 630626006274 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 630626006275 Phage-related protein, tail component [Function unknown]; Region: COG4723 630626006276 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 630626006277 GIY-YIG motif/motif A; other site 630626006278 putative active site [active] 630626006279 putative metal binding site [ion binding]; other site 630626006280 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 630626006281 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 630626006282 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 630626006283 MPN+ (JAMM) motif; other site 630626006284 Zinc-binding site [ion binding]; other site 630626006285 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 630626006286 NlpC/P60 family; Region: NLPC_P60; pfam00877 630626006287 Phage minor tail protein L; Region: Phage_tail_L; cl01908 630626006288 Phage minor tail protein; Region: Phage_min_tail; pfam05939 630626006289 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 630626006290 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 630626006291 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 630626006292 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 630626006293 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 630626006294 oligomerization interface [polypeptide binding]; other site 630626006295 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 630626006296 Phage capsid family; Region: Phage_capsid; pfam05065 630626006297 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 630626006298 Phage portal protein; Region: Phage_portal; pfam04860 630626006299 Phage-related protein [Function unknown]; Region: COG4695 630626006300 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 630626006301 Phage terminase, small subunit; Region: Terminase_4; pfam05119 630626006302 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 630626006303 Predicted chitinase [General function prediction only]; Region: COG3179 630626006304 catalytic residue [active] 630626006305 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 630626006306 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 630626006307 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 630626006308 DNA methylase; Region: N6_N4_Mtase; pfam01555 630626006309 Transposase; Region: HTH_Tnp_1; pfam01527 630626006310 HTH-like domain; Region: HTH_21; pfam13276 630626006311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626006312 Integrase core domain; Region: rve; pfam00665 630626006313 Integrase core domain; Region: rve_3; pfam13683 630626006314 DNA methylase; Region: N6_N4_Mtase; cl17433 630626006315 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 630626006316 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 630626006317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 630626006318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 630626006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626006320 ATP binding site [chemical binding]; other site 630626006321 Mg2+ binding site [ion binding]; other site 630626006322 G-X-G motif; other site 630626006323 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 630626006324 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 630626006325 cofactor binding site; other site 630626006326 DNA binding site [nucleotide binding] 630626006327 substrate interaction site [chemical binding]; other site 630626006328 putative replication protein; Provisional; Region: PRK12377 630626006329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626006330 Walker A motif; other site 630626006331 ATP binding site [chemical binding]; other site 630626006332 Walker B motif; other site 630626006333 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 630626006334 transcriptional repressor DicA; Reviewed; Region: PRK09706 630626006335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626006336 non-specific DNA binding site [nucleotide binding]; other site 630626006337 salt bridge; other site 630626006338 sequence-specific DNA binding site [nucleotide binding]; other site 630626006339 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 630626006340 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 630626006341 active site 630626006342 substrate binding site [chemical binding]; other site 630626006343 catalytic site [active] 630626006344 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 630626006345 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 630626006346 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 630626006347 Int/Topo IB signature motif; other site 630626006348 IS2 transposase TnpB; Reviewed; Region: PRK09409 630626006349 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 630626006350 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 630626006351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626006352 Coenzyme A binding pocket [chemical binding]; other site 630626006353 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 630626006354 DJ-1 family protein; Region: not_thiJ; TIGR01383 630626006355 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 630626006356 conserved cys residue [active] 630626006357 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 630626006358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006359 galactoside permease; Reviewed; Region: lacY; PRK09528 630626006360 putative substrate translocation pore; other site 630626006361 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 630626006362 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 630626006363 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 630626006364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626006365 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 630626006366 Protein of unknown function (DUF330); Region: DUF330; cl01135 630626006367 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 630626006368 mce related protein; Region: MCE; pfam02470 630626006369 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 630626006370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626006371 Walker A/P-loop; other site 630626006372 ATP binding site [chemical binding]; other site 630626006373 Q-loop/lid; other site 630626006374 ABC transporter signature motif; other site 630626006375 Walker B; other site 630626006376 D-loop; other site 630626006377 H-loop/switch region; other site 630626006378 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 630626006379 Permease; Region: Permease; pfam02405 630626006380 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 630626006381 CcdB protein; Region: CcdB; pfam01845 630626006382 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 630626006383 leucine export protein LeuE; Provisional; Region: PRK10958 630626006384 cytochrome b561; Provisional; Region: PRK11513 630626006385 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 630626006386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626006387 ATP binding site [chemical binding]; other site 630626006388 putative Mg++ binding site [ion binding]; other site 630626006389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626006390 nucleotide binding region [chemical binding]; other site 630626006391 ATP-binding site [chemical binding]; other site 630626006392 Helicase associated domain (HA2); Region: HA2; pfam04408 630626006393 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 630626006394 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 630626006395 azoreductase; Reviewed; Region: PRK00170 630626006396 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626006397 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 630626006398 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 630626006399 putative trimer interface [polypeptide binding]; other site 630626006400 putative metal binding site [ion binding]; other site 630626006401 PaaX-like protein; Region: PaaX; pfam07848 630626006402 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 630626006403 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 630626006404 YfaZ precursor; Region: YfaZ; pfam07437 630626006405 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 630626006406 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 630626006407 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 630626006408 acyl-activating enzyme (AAE) consensus motif; other site 630626006409 AMP binding site [chemical binding]; other site 630626006410 active site 630626006411 CoA binding site [chemical binding]; other site 630626006412 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 630626006413 2-methylcitrate dehydratase; Region: prpD; TIGR02330 630626006414 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 630626006415 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 630626006416 dimer interface [polypeptide binding]; other site 630626006417 active site 630626006418 citrylCoA binding site [chemical binding]; other site 630626006419 oxalacetate/citrate binding site [chemical binding]; other site 630626006420 coenzyme A binding site [chemical binding]; other site 630626006421 catalytic triad [active] 630626006422 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 630626006423 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 630626006424 tetramer interface [polypeptide binding]; other site 630626006425 active site 630626006426 Mg2+/Mn2+ binding site [ion binding]; other site 630626006427 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 630626006428 Propionate catabolism activator; Region: PrpR_N; pfam06506 630626006429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626006430 Walker A motif; other site 630626006431 ATP binding site [chemical binding]; other site 630626006432 Walker B motif; other site 630626006433 arginine finger; other site 630626006434 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 630626006435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626006436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626006437 metal binding site [ion binding]; metal-binding site 630626006438 active site 630626006439 I-site; other site 630626006440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626006441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626006442 metal binding site [ion binding]; metal-binding site 630626006443 active site 630626006444 I-site; other site 630626006445 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 630626006446 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626006447 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 630626006448 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626006449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626006450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006451 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 630626006452 putative effector binding pocket; other site 630626006453 putative dimerization interface [polypeptide binding]; other site 630626006454 transcriptional regulator NarP; Provisional; Region: PRK10403 630626006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626006456 active site 630626006457 phosphorylation site [posttranslational modification] 630626006458 intermolecular recognition site; other site 630626006459 dimerization interface [polypeptide binding]; other site 630626006460 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626006461 DNA binding residues [nucleotide binding] 630626006462 dimerization interface [polypeptide binding]; other site 630626006463 Cytochrome C biogenesis protein; Region: CcmH; cl01179 630626006464 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 630626006465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 630626006466 binding surface 630626006467 TPR motif; other site 630626006468 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 630626006469 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 630626006470 catalytic residues [active] 630626006471 central insert; other site 630626006472 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 630626006473 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 630626006474 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 630626006475 heme exporter protein CcmC; Region: ccmC; TIGR01191 630626006476 heme exporter protein CcmB; Region: ccmB; TIGR01190 630626006477 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 630626006478 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 630626006479 Walker A/P-loop; other site 630626006480 ATP binding site [chemical binding]; other site 630626006481 Q-loop/lid; other site 630626006482 ABC transporter signature motif; other site 630626006483 Walker B; other site 630626006484 D-loop; other site 630626006485 H-loop/switch region; other site 630626006486 cytochrome c-type protein NapC; Provisional; Region: PRK10617 630626006487 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 630626006488 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 630626006489 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 630626006490 4Fe-4S binding domain; Region: Fer4_5; pfam12801 630626006491 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 630626006492 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 630626006493 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 630626006494 [4Fe-4S] binding site [ion binding]; other site 630626006495 molybdopterin cofactor binding site; other site 630626006496 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 630626006497 molybdopterin cofactor binding site; other site 630626006498 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 630626006499 ferredoxin-type protein; Provisional; Region: PRK10194 630626006500 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 630626006501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 630626006502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626006503 DNA-binding site [nucleotide binding]; DNA binding site 630626006504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626006505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626006506 homodimer interface [polypeptide binding]; other site 630626006507 catalytic residue [active] 630626006508 Secretory lipase; Region: LIP; pfam03583 630626006509 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 630626006510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626006511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006512 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626006513 putative effector binding pocket; other site 630626006514 dimerization interface [polypeptide binding]; other site 630626006515 Pirin-related protein [General function prediction only]; Region: COG1741 630626006516 Pirin; Region: Pirin; pfam02678 630626006517 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 630626006518 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 630626006519 Isochorismatase family; Region: Isochorismatase; pfam00857 630626006520 catalytic triad [active] 630626006521 dimer interface [polypeptide binding]; other site 630626006522 conserved cis-peptide bond; other site 630626006523 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 630626006524 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 630626006525 active site 630626006526 Zn binding site [ion binding]; other site 630626006527 malonic semialdehyde reductase; Provisional; Region: PRK10538 630626006528 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 630626006529 putative NAD(P) binding site [chemical binding]; other site 630626006530 homodimer interface [polypeptide binding]; other site 630626006531 homotetramer interface [polypeptide binding]; other site 630626006532 active site 630626006533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 630626006534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626006535 DNA-binding site [nucleotide binding]; DNA binding site 630626006536 FCD domain; Region: FCD; pfam07729 630626006537 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 630626006538 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 630626006539 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 630626006540 metabolite-proton symporter; Region: 2A0106; TIGR00883 630626006541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006542 putative substrate translocation pore; other site 630626006543 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 630626006544 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 630626006545 DNA-binding interface [nucleotide binding]; DNA binding site 630626006546 Y-family of DNA polymerases; Region: PolY; cl12025 630626006547 Y-family of DNA polymerases; Region: PolY; cl12025 630626006548 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 630626006549 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 630626006550 Acyltransferase family; Region: Acyl_transf_3; pfam01757 630626006551 Head binding; Region: Head_binding; pfam09008 630626006552 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 630626006553 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626006554 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626006555 catalytic residue [active] 630626006556 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 630626006557 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 630626006558 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 630626006559 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 630626006560 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 630626006561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626006562 Transposase; Region: HTH_Tnp_1; cl17663 630626006563 HTH-like domain; Region: HTH_21; pfam13276 630626006564 Integrase core domain; Region: rve; pfam00665 630626006565 Transposase; Region: DEDD_Tnp_IS110; pfam01548 630626006566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 630626006567 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 630626006568 putative transposase OrfB; Reviewed; Region: PHA02517 630626006569 Terminase-like family; Region: Terminase_6; pfam03237 630626006570 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 630626006571 hypothetical protein; Region: PHA00527 630626006572 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 630626006573 KilA-N domain; Region: KilA-N; pfam04383 630626006574 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 630626006575 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 630626006576 catalytic residues [active] 630626006577 Lysis protein S; Region: Lysis_S; pfam04971 630626006578 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 630626006579 NinB protein; Region: NinB; pfam05772 630626006580 AAA domain; Region: AAA_27; pfam13514 630626006581 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 630626006582 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 630626006583 cofactor binding site; other site 630626006584 DNA binding site [nucleotide binding] 630626006585 substrate interaction site [chemical binding]; other site 630626006586 replicative DNA helicase; Region: DnaB; TIGR00665 630626006587 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 630626006588 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 630626006589 Walker A motif; other site 630626006590 ATP binding site [chemical binding]; other site 630626006591 Walker B motif; other site 630626006592 DNA binding loops [nucleotide binding] 630626006593 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 630626006594 Bacteriophage CII protein; Region: Phage_CII; pfam05269 630626006595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626006596 non-specific DNA binding site [nucleotide binding]; other site 630626006597 salt bridge; other site 630626006598 sequence-specific DNA binding site [nucleotide binding]; other site 630626006599 Predicted transcriptional regulator [Transcription]; Region: COG2932 630626006600 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 630626006601 Catalytic site [active] 630626006602 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 630626006603 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 630626006604 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 630626006605 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 630626006606 dimer interface [polypeptide binding]; other site 630626006607 ssDNA binding site [nucleotide binding]; other site 630626006608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 630626006609 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 630626006610 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 630626006611 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 630626006612 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 630626006613 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 630626006614 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 630626006615 Int/Topo IB signature motif; other site 630626006616 putative oxidoreductase; Provisional; Region: PRK10083 630626006617 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 630626006618 putative NAD(P) binding site [chemical binding]; other site 630626006619 catalytic Zn binding site [ion binding]; other site 630626006620 structural Zn binding site [ion binding]; other site 630626006621 hypothetical protein; Provisional; Region: PRK13659 630626006622 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 630626006623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626006624 Coenzyme A binding pocket [chemical binding]; other site 630626006625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 630626006626 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 630626006627 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 630626006628 putative dithiobiotin synthetase; Provisional; Region: PRK12374 630626006629 AAA domain; Region: AAA_26; pfam13500 630626006630 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 630626006631 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 630626006632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626006633 nucleotide binding site [chemical binding]; other site 630626006634 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 630626006635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006636 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 630626006637 dimerization interface [polypeptide binding]; other site 630626006638 substrate binding pocket [chemical binding]; other site 630626006639 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 630626006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006641 putative substrate translocation pore; other site 630626006642 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 630626006643 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 630626006644 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 630626006645 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 630626006646 Domain of unknown function DUF20; Region: UPF0118; pfam01594 630626006647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 630626006648 Smr domain; Region: Smr; pfam01713 630626006649 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 630626006650 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 630626006651 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 630626006652 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 630626006653 DNA binding site [nucleotide binding] 630626006654 active site 630626006655 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 630626006656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 630626006657 ligand binding site [chemical binding]; other site 630626006658 flexible hinge region; other site 630626006659 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 630626006660 putative switch regulator; other site 630626006661 non-specific DNA interactions [nucleotide binding]; other site 630626006662 DNA binding site [nucleotide binding] 630626006663 sequence specific DNA binding site [nucleotide binding]; other site 630626006664 putative cAMP binding site [chemical binding]; other site 630626006665 universal stress protein UspE; Provisional; Region: PRK11175 630626006666 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626006667 Ligand Binding Site [chemical binding]; other site 630626006668 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 630626006669 Ligand Binding Site [chemical binding]; other site 630626006670 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 630626006671 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 630626006672 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 630626006673 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 630626006674 ligand binding site [chemical binding]; other site 630626006675 homodimer interface [polypeptide binding]; other site 630626006676 NAD(P) binding site [chemical binding]; other site 630626006677 trimer interface B [polypeptide binding]; other site 630626006678 trimer interface A [polypeptide binding]; other site 630626006679 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 630626006680 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626006681 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626006682 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626006683 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 630626006684 dihydromonapterin reductase; Provisional; Region: PRK06483 630626006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626006686 NAD(P) binding site [chemical binding]; other site 630626006687 active site 630626006688 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 630626006689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626006690 active site 630626006691 phosphorylation site [posttranslational modification] 630626006692 intermolecular recognition site; other site 630626006693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626006694 DNA binding site [nucleotide binding] 630626006695 sensor protein RstB; Provisional; Region: PRK10604 630626006696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626006697 dimerization interface [polypeptide binding]; other site 630626006698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626006699 dimer interface [polypeptide binding]; other site 630626006700 phosphorylation site [posttranslational modification] 630626006701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626006702 ATP binding site [chemical binding]; other site 630626006703 Mg2+ binding site [ion binding]; other site 630626006704 G-X-G motif; other site 630626006705 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 630626006706 fumarate hydratase; Reviewed; Region: fumC; PRK00485 630626006707 Class II fumarases; Region: Fumarase_classII; cd01362 630626006708 active site 630626006709 tetramer interface [polypeptide binding]; other site 630626006710 Protein of unknown function (DUF796); Region: DUF796; cl01226 630626006711 fumarate hydratase; Provisional; Region: PRK15389 630626006712 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 630626006713 Fumarase C-terminus; Region: Fumerase_C; pfam05683 630626006714 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 630626006715 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 630626006716 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 630626006717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 630626006718 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 630626006719 Protein of unknown function; Region: YhfT; pfam10797 630626006720 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 630626006721 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 630626006722 active site 630626006723 substrate binding pocket [chemical binding]; other site 630626006724 homodimer interaction site [polypeptide binding]; other site 630626006725 putative mutase; Provisional; Region: PRK12383 630626006726 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 630626006727 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 630626006728 dimer interface [polypeptide binding]; other site 630626006729 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 630626006730 active site 630626006731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626006732 substrate binding site [chemical binding]; other site 630626006733 catalytic residue [active] 630626006734 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 630626006735 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626006736 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 630626006737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626006738 DNA binding site [nucleotide binding] 630626006739 domain linker motif; other site 630626006740 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 630626006741 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 630626006742 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 630626006743 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 630626006744 active site turn [active] 630626006745 phosphorylation site [posttranslational modification] 630626006746 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 630626006747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626006748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626006749 homodimer interface [polypeptide binding]; other site 630626006750 catalytic residue [active] 630626006751 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 630626006752 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 630626006753 active site 630626006754 purine riboside binding site [chemical binding]; other site 630626006755 putative oxidoreductase; Provisional; Region: PRK11579 630626006756 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 630626006757 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 630626006758 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 630626006759 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 630626006760 electron transport complex protein RsxA; Provisional; Region: PRK05151 630626006761 electron transport complex protein RnfB; Provisional; Region: PRK05113 630626006762 Putative Fe-S cluster; Region: FeS; pfam04060 630626006763 4Fe-4S binding domain; Region: Fer4; pfam00037 630626006764 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 630626006765 SLBB domain; Region: SLBB; pfam10531 630626006766 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626006767 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 630626006768 electron transport complex protein RnfG; Validated; Region: PRK01908 630626006769 electron transport complex RsxE subunit; Provisional; Region: PRK12405 630626006770 endonuclease III; Provisional; Region: PRK10702 630626006771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 630626006772 minor groove reading motif; other site 630626006773 helix-hairpin-helix signature motif; other site 630626006774 substrate binding pocket [chemical binding]; other site 630626006775 active site 630626006776 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 630626006777 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 630626006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006779 putative substrate translocation pore; other site 630626006780 POT family; Region: PTR2; pfam00854 630626006781 glutathionine S-transferase; Provisional; Region: PRK10542 630626006782 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 630626006783 C-terminal domain interface [polypeptide binding]; other site 630626006784 GSH binding site (G-site) [chemical binding]; other site 630626006785 dimer interface [polypeptide binding]; other site 630626006786 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 630626006787 dimer interface [polypeptide binding]; other site 630626006788 N-terminal domain interface [polypeptide binding]; other site 630626006789 substrate binding pocket (H-site) [chemical binding]; other site 630626006790 pyridoxamine kinase; Validated; Region: PRK05756 630626006791 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 630626006792 dimer interface [polypeptide binding]; other site 630626006793 pyridoxal binding site [chemical binding]; other site 630626006794 ATP binding site [chemical binding]; other site 630626006795 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 630626006796 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 630626006797 active site 630626006798 HIGH motif; other site 630626006799 dimer interface [polypeptide binding]; other site 630626006800 KMSKS motif; other site 630626006801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626006802 RNA binding surface [nucleotide binding]; other site 630626006803 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 630626006804 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 630626006805 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 630626006806 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 630626006807 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 630626006808 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 630626006809 transcriptional regulator SlyA; Provisional; Region: PRK03573 630626006810 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 630626006811 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 630626006812 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 630626006813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626006814 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626006815 Fusaric acid resistance protein family; Region: FUSC; pfam04632 630626006816 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 630626006817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 630626006818 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 630626006819 active site 630626006820 catalytic tetrad [active] 630626006821 Predicted Fe-S protein [General function prediction only]; Region: COG3313 630626006822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626006823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626006824 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 630626006825 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 630626006826 FMN binding site [chemical binding]; other site 630626006827 active site 630626006828 substrate binding site [chemical binding]; other site 630626006829 catalytic residue [active] 630626006830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 630626006831 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 630626006832 dimer interface [polypeptide binding]; other site 630626006833 active site 630626006834 metal binding site [ion binding]; metal-binding site 630626006835 glutathione binding site [chemical binding]; other site 630626006836 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 630626006837 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 630626006838 dimer interface [polypeptide binding]; other site 630626006839 catalytic site [active] 630626006840 putative active site [active] 630626006841 putative substrate binding site [chemical binding]; other site 630626006842 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 630626006843 putative GSH binding site [chemical binding]; other site 630626006844 catalytic residues [active] 630626006845 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 630626006846 NlpC/P60 family; Region: NLPC_P60; pfam00877 630626006847 superoxide dismutase; Provisional; Region: PRK10543 630626006848 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 630626006849 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 630626006850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626006852 putative substrate translocation pore; other site 630626006853 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 630626006854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626006855 DNA binding site [nucleotide binding] 630626006856 domain linker motif; other site 630626006857 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 630626006858 dimerization interface [polypeptide binding]; other site 630626006859 ligand binding site [chemical binding]; other site 630626006860 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 630626006861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626006862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626006863 dimerization interface [polypeptide binding]; other site 630626006864 putative transporter; Provisional; Region: PRK11043 630626006865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626006866 putative substrate translocation pore; other site 630626006867 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 630626006868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 630626006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626006870 S-adenosylmethionine binding site [chemical binding]; other site 630626006871 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 630626006872 Lumazine binding domain; Region: Lum_binding; pfam00677 630626006873 Lumazine binding domain; Region: Lum_binding; pfam00677 630626006874 multidrug efflux protein; Reviewed; Region: PRK01766 630626006875 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 630626006876 cation binding site [ion binding]; other site 630626006877 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 630626006878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626006879 active site 630626006880 motif I; other site 630626006881 motif II; other site 630626006882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626006883 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 630626006884 Predicted amidohydrolase [General function prediction only]; Region: COG0388 630626006885 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 630626006886 active site 630626006887 catalytic triad [active] 630626006888 dimer interface [polypeptide binding]; other site 630626006889 exodeoxyribonuclease X; Provisional; Region: PRK07983 630626006890 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 630626006891 active site 630626006892 catalytic site [active] 630626006893 substrate binding site [chemical binding]; other site 630626006894 protease 2; Provisional; Region: PRK10115 630626006895 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 630626006896 YebG protein; Region: YebG; cl01217 630626006897 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 630626006898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626006899 ATP-grasp domain; Region: ATP-grasp; pfam02222 630626006900 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 630626006901 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 630626006902 active site 630626006903 intersubunit interface [polypeptide binding]; other site 630626006904 catalytic residue [active] 630626006905 phosphogluconate dehydratase; Validated; Region: PRK09054 630626006906 6-phosphogluconate dehydratase; Region: edd; TIGR01196 630626006907 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 630626006908 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 630626006909 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 630626006910 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 630626006911 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 630626006912 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 630626006913 putative active site [active] 630626006914 pyruvate kinase; Provisional; Region: PRK05826 630626006915 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 630626006916 domain interfaces; other site 630626006917 active site 630626006918 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 630626006919 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 630626006920 putative acyl-acceptor binding pocket; other site 630626006921 putative peptidase; Provisional; Region: PRK11649 630626006922 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 630626006923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626006924 Peptidase family M23; Region: Peptidase_M23; pfam01551 630626006925 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 630626006926 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 630626006927 metal binding site [ion binding]; metal-binding site 630626006928 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 630626006929 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 630626006930 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 630626006931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626006932 ABC-ATPase subunit interface; other site 630626006933 dimer interface [polypeptide binding]; other site 630626006934 putative PBP binding regions; other site 630626006935 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 630626006936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626006937 Walker A motif; other site 630626006938 ATP binding site [chemical binding]; other site 630626006939 Walker B motif; other site 630626006940 arginine finger; other site 630626006941 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 630626006942 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 630626006943 RuvA N terminal domain; Region: RuvA_N; pfam01330 630626006944 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 630626006945 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 630626006946 active site 630626006947 putative DNA-binding cleft [nucleotide binding]; other site 630626006948 dimer interface [polypeptide binding]; other site 630626006949 hypothetical protein; Validated; Region: PRK00110 630626006950 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 630626006951 nudix motif; other site 630626006952 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 630626006953 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 630626006954 dimer interface [polypeptide binding]; other site 630626006955 anticodon binding site; other site 630626006956 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 630626006957 homodimer interface [polypeptide binding]; other site 630626006958 motif 1; other site 630626006959 active site 630626006960 motif 2; other site 630626006961 GAD domain; Region: GAD; pfam02938 630626006962 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 630626006963 active site 630626006964 motif 3; other site 630626006965 Protein of unknown function DUF72; Region: DUF72; cl00777 630626006966 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 630626006967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626006968 S-adenosylmethionine binding site [chemical binding]; other site 630626006969 Methyltransferase domain; Region: Methyltransf_23; pfam13489 630626006970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626006971 S-adenosylmethionine binding site [chemical binding]; other site 630626006972 copper homeostasis protein CutC; Provisional; Region: PRK11572 630626006973 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 630626006974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626006975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626006976 homodimer interface [polypeptide binding]; other site 630626006977 catalytic residue [active] 630626006978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 630626006979 putative metal binding site [ion binding]; other site 630626006980 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 630626006981 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 630626006982 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 630626006983 active site 630626006984 HIGH motif; other site 630626006985 KMSK motif region; other site 630626006986 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 630626006987 tRNA binding surface [nucleotide binding]; other site 630626006988 anticodon binding site; other site 630626006989 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 630626006990 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 630626006991 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 630626006992 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 630626006993 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 630626006994 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 630626006995 aromatic amino acid exporter; Provisional; Region: PRK11689 630626006996 EamA-like transporter family; Region: EamA; cl17759 630626006997 N-formylglutamate amidohydrolase; Region: FGase; cl01522 630626006998 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 630626006999 dimer interface [polypeptide binding]; other site 630626007000 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 630626007001 putative catalytic site [active] 630626007002 putative phosphate binding site [ion binding]; other site 630626007003 active site 630626007004 metal binding site A [ion binding]; metal-binding site 630626007005 DNA binding site [nucleotide binding] 630626007006 putative AP binding site [nucleotide binding]; other site 630626007007 putative metal binding site B [ion binding]; other site 630626007008 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 630626007009 active site 630626007010 8-oxo-dGMP binding site [chemical binding]; other site 630626007011 nudix motif; other site 630626007012 metal binding site [ion binding]; metal-binding site 630626007013 glutamate dehydrogenase; Provisional; Region: PRK09414 630626007014 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 630626007015 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 630626007016 NAD(P) binding site [chemical binding]; other site 630626007017 DNA topoisomerase III; Provisional; Region: PRK07726 630626007018 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 630626007019 active site 630626007020 putative interdomain interaction site [polypeptide binding]; other site 630626007021 putative metal-binding site [ion binding]; other site 630626007022 putative nucleotide binding site [chemical binding]; other site 630626007023 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 630626007024 domain I; other site 630626007025 DNA binding groove [nucleotide binding] 630626007026 phosphate binding site [ion binding]; other site 630626007027 domain II; other site 630626007028 domain III; other site 630626007029 nucleotide binding site [chemical binding]; other site 630626007030 catalytic site [active] 630626007031 domain IV; other site 630626007032 selenophosphate synthetase; Provisional; Region: PRK00943 630626007033 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 630626007034 dimerization interface [polypeptide binding]; other site 630626007035 putative ATP binding site [chemical binding]; other site 630626007036 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 630626007037 putative FMN binding site [chemical binding]; other site 630626007038 protease 4; Provisional; Region: PRK10949 630626007039 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 630626007040 tandem repeat interface [polypeptide binding]; other site 630626007041 oligomer interface [polypeptide binding]; other site 630626007042 active site residues [active] 630626007043 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 630626007044 tandem repeat interface [polypeptide binding]; other site 630626007045 oligomer interface [polypeptide binding]; other site 630626007046 active site residues [active] 630626007047 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 630626007048 active site 630626007049 homodimer interface [polypeptide binding]; other site 630626007050 Isochorismatase family; Region: Isochorismatase; pfam00857 630626007051 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 630626007052 catalytic triad [active] 630626007053 metal binding site [ion binding]; metal-binding site 630626007054 conserved cis-peptide bond; other site 630626007055 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 630626007056 methionine sulfoxide reductase B; Provisional; Region: PRK00222 630626007057 SelR domain; Region: SelR; pfam01641 630626007058 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 630626007059 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 630626007060 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 630626007061 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 630626007062 active site 630626007063 phosphate binding residues; other site 630626007064 catalytic residues [active] 630626007065 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 630626007066 PrkA family serine protein kinase; Provisional; Region: PRK15455 630626007067 AAA ATPase domain; Region: AAA_16; pfam13191 630626007068 Walker A motif; other site 630626007069 ATP binding site [chemical binding]; other site 630626007070 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 630626007071 hypothetical protein; Provisional; Region: PRK05325 630626007072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 630626007073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626007074 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 630626007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007076 putative substrate translocation pore; other site 630626007077 Protein of unknown function, DUF488; Region: DUF488; cl01246 630626007078 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 630626007079 Domain of unknown function (DUF333); Region: DUF333; pfam03891 630626007080 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 630626007081 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 630626007082 putative acyl-acceptor binding pocket; other site 630626007083 acetoin reductase; Validated; Region: PRK08643 630626007084 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 630626007085 NAD binding site [chemical binding]; other site 630626007086 homotetramer interface [polypeptide binding]; other site 630626007087 homodimer interface [polypeptide binding]; other site 630626007088 active site 630626007089 substrate binding site [chemical binding]; other site 630626007090 isocitrate dehydrogenase; Validated; Region: PRK07362 630626007091 isocitrate dehydrogenase; Reviewed; Region: PRK07006 630626007092 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 630626007093 pseudouridine synthase; Region: TIGR00093 630626007094 probable active site [active] 630626007095 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 630626007096 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 630626007097 nudix motif; other site 630626007098 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 630626007099 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 630626007100 putative lysogenization regulator; Reviewed; Region: PRK00218 630626007101 adenylosuccinate lyase; Provisional; Region: PRK09285 630626007102 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 630626007103 tetramer interface [polypeptide binding]; other site 630626007104 active site 630626007105 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 630626007106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626007107 active site 630626007108 phosphorylation site [posttranslational modification] 630626007109 intermolecular recognition site; other site 630626007110 dimerization interface [polypeptide binding]; other site 630626007111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626007112 DNA binding site [nucleotide binding] 630626007113 sensor protein PhoQ; Provisional; Region: PRK10815 630626007114 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 630626007115 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 630626007116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626007117 ATP binding site [chemical binding]; other site 630626007118 Mg2+ binding site [ion binding]; other site 630626007119 G-X-G motif; other site 630626007120 Uncharacterized conserved protein [Function unknown]; Region: COG2850 630626007121 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 630626007122 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 630626007123 metal binding site [ion binding]; metal-binding site 630626007124 dimer interface [polypeptide binding]; other site 630626007125 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 630626007126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007127 Walker A/P-loop; other site 630626007128 ATP binding site [chemical binding]; other site 630626007129 Q-loop/lid; other site 630626007130 ABC transporter signature motif; other site 630626007131 Walker B; other site 630626007132 D-loop; other site 630626007133 H-loop/switch region; other site 630626007134 TOBE domain; Region: TOBE_2; pfam08402 630626007135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007136 dimer interface [polypeptide binding]; other site 630626007137 conserved gate region; other site 630626007138 putative PBP binding loops; other site 630626007139 ABC-ATPase subunit interface; other site 630626007140 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 630626007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007142 dimer interface [polypeptide binding]; other site 630626007143 conserved gate region; other site 630626007144 putative PBP binding loops; other site 630626007145 ABC-ATPase subunit interface; other site 630626007146 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 630626007147 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 630626007148 NAD-dependent deacetylase; Provisional; Region: PRK00481 630626007149 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 630626007150 NAD+ binding site [chemical binding]; other site 630626007151 substrate binding site [chemical binding]; other site 630626007152 Zn binding site [ion binding]; other site 630626007153 fructokinase; Reviewed; Region: PRK09557 630626007154 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626007155 nucleotide binding site [chemical binding]; other site 630626007156 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 630626007157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 630626007158 FtsX-like permease family; Region: FtsX; pfam02687 630626007159 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 630626007160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 630626007161 Walker A/P-loop; other site 630626007162 ATP binding site [chemical binding]; other site 630626007163 Q-loop/lid; other site 630626007164 ABC transporter signature motif; other site 630626007165 Walker B; other site 630626007166 D-loop; other site 630626007167 H-loop/switch region; other site 630626007168 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 630626007169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 630626007170 FtsX-like permease family; Region: FtsX; pfam02687 630626007171 transcription-repair coupling factor; Provisional; Region: PRK10689 630626007172 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 630626007173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626007174 ATP binding site [chemical binding]; other site 630626007175 putative Mg++ binding site [ion binding]; other site 630626007176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626007177 nucleotide binding region [chemical binding]; other site 630626007178 ATP-binding site [chemical binding]; other site 630626007179 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 630626007180 L,D-transpeptidase; Provisional; Region: PRK10260 630626007181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626007182 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626007183 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626007184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626007185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626007186 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 630626007187 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 630626007188 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 630626007189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626007190 hypothetical protein; Provisional; Region: PRK04940 630626007191 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 630626007192 beta-hexosaminidase; Provisional; Region: PRK05337 630626007193 thiamine kinase; Region: ycfN_thiK; TIGR02721 630626007194 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 630626007195 active site 630626007196 ATP binding site [chemical binding]; other site 630626007197 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 630626007198 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 630626007199 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 630626007200 putative dimer interface [polypeptide binding]; other site 630626007201 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 630626007202 nucleotide binding site/active site [active] 630626007203 HIT family signature motif; other site 630626007204 catalytic residue [active] 630626007205 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 630626007206 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 630626007207 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 630626007208 active site turn [active] 630626007209 phosphorylation site [posttranslational modification] 630626007210 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 630626007211 active site 630626007212 DNA polymerase III subunit delta'; Validated; Region: PRK07993 630626007213 DNA polymerase III subunit delta'; Validated; Region: PRK08485 630626007214 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 630626007215 thymidylate kinase; Validated; Region: tmk; PRK00698 630626007216 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 630626007217 TMP-binding site; other site 630626007218 ATP-binding site [chemical binding]; other site 630626007219 conserved hypothetical protein, YceG family; Region: TIGR00247 630626007220 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 630626007221 dimerization interface [polypeptide binding]; other site 630626007222 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 630626007223 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 630626007224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626007225 catalytic residue [active] 630626007226 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 630626007227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 630626007228 dimer interface [polypeptide binding]; other site 630626007229 active site 630626007230 acyl carrier protein; Provisional; Region: acpP; PRK00982 630626007231 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 630626007232 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 630626007233 NAD(P) binding site [chemical binding]; other site 630626007234 homotetramer interface [polypeptide binding]; other site 630626007235 homodimer interface [polypeptide binding]; other site 630626007236 active site 630626007237 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 630626007238 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 630626007239 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 630626007240 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 630626007241 dimer interface [polypeptide binding]; other site 630626007242 active site 630626007243 CoA binding pocket [chemical binding]; other site 630626007244 putative phosphate acyltransferase; Provisional; Region: PRK05331 630626007245 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 630626007246 hypothetical protein; Provisional; Region: PRK11193 630626007247 Maf-like protein; Region: Maf; pfam02545 630626007248 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 630626007249 active site 630626007250 dimer interface [polypeptide binding]; other site 630626007251 Methyltransferase domain; Region: Methyltransf_31; pfam13847 630626007252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007253 S-adenosylmethionine binding site [chemical binding]; other site 630626007254 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 630626007255 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 630626007256 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 630626007257 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626007258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626007259 ABC-ATPase subunit interface; other site 630626007260 dimer interface [polypeptide binding]; other site 630626007261 putative PBP binding regions; other site 630626007262 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 630626007263 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 630626007264 intersubunit interface [polypeptide binding]; other site 630626007265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 630626007266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 630626007267 ligand binding site [chemical binding]; other site 630626007268 flexible hinge region; other site 630626007269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 630626007270 putative switch regulator; other site 630626007271 non-specific DNA interactions [nucleotide binding]; other site 630626007272 DNA binding site [nucleotide binding] 630626007273 sequence specific DNA binding site [nucleotide binding]; other site 630626007274 putative cAMP binding site [chemical binding]; other site 630626007275 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 630626007276 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626007277 N-terminal plug; other site 630626007278 ligand-binding site [chemical binding]; other site 630626007279 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 630626007280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626007281 RNA binding surface [nucleotide binding]; other site 630626007282 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 630626007283 active site 630626007284 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 630626007285 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 630626007286 homodimer interface [polypeptide binding]; other site 630626007287 oligonucleotide binding site [chemical binding]; other site 630626007288 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 630626007289 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 630626007290 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 630626007291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 630626007292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 630626007293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 630626007294 hypothetical protein; Provisional; Region: PRK11239 630626007295 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 630626007296 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 630626007297 multidrug resistance protein MdtH; Provisional; Region: PRK11646 630626007298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007299 putative substrate translocation pore; other site 630626007300 lipoprotein; Provisional; Region: PRK10598 630626007301 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 630626007302 active site 630626007303 substrate binding pocket [chemical binding]; other site 630626007304 dimer interface [polypeptide binding]; other site 630626007305 DNA damage-inducible protein I; Provisional; Region: PRK10597 630626007306 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 630626007307 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 630626007308 hydroxyglutarate oxidase; Provisional; Region: PRK11728 630626007309 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 630626007310 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 630626007311 active site residue [active] 630626007312 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 630626007313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 630626007314 putative acyl-acceptor binding pocket; other site 630626007315 drug efflux system protein MdtG; Provisional; Region: PRK09874 630626007316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007317 putative substrate translocation pore; other site 630626007318 MsyB protein; Region: MsyB; cl08181 630626007319 lipoprotein; Provisional; Region: PRK10175 630626007320 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 630626007321 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 630626007322 Ligand binding site; other site 630626007323 DXD motif; other site 630626007324 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 630626007325 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 630626007326 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 630626007327 Acyltransferase family; Region: Acyl_transf_3; pfam01757 630626007328 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 630626007329 putative ADP-ribose binding site [chemical binding]; other site 630626007330 putative active site [active] 630626007331 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 630626007332 putative hydrolase; Validated; Region: PRK09248 630626007333 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 630626007334 active site 630626007335 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 630626007336 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 630626007337 putative ligand binding site [chemical binding]; other site 630626007338 NAD binding site [chemical binding]; other site 630626007339 dimerization interface [polypeptide binding]; other site 630626007340 catalytic site [active] 630626007341 hypothetical protein; Provisional; Region: PRK10536 630626007342 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 630626007343 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 630626007344 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 630626007345 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 630626007346 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 630626007347 Imelysin; Region: Peptidase_M75; pfam09375 630626007348 Iron permease FTR1 family; Region: FTR1; cl00475 630626007349 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 630626007350 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 630626007351 Na binding site [ion binding]; other site 630626007352 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 630626007353 Predicted transcriptional regulator [Transcription]; Region: COG3905 630626007354 Proline dehydrogenase; Region: Pro_dh; pfam01619 630626007355 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 630626007356 Glutamate binding site [chemical binding]; other site 630626007357 NAD binding site [chemical binding]; other site 630626007358 catalytic residues [active] 630626007359 EamA-like transporter family; Region: EamA; pfam00892 630626007360 General stress protein [General function prediction only]; Region: GsiB; COG3729 630626007361 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 630626007362 hypothetical protein; Provisional; Region: PRK10174 630626007363 hypothetical protein; Provisional; Region: PRK10649 630626007364 Sulfatase; Region: Sulfatase; pfam00884 630626007365 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 630626007366 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 630626007367 catalytic residues [active] 630626007368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626007369 Integrase core domain; Region: rve; pfam00665 630626007370 YccA-like proteins; Region: YccA_like; cd10433 630626007371 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 630626007372 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 630626007373 sulfur transfer protein TusE; Provisional; Region: PRK11508 630626007374 acylphosphatase; Provisional; Region: PRK14426 630626007375 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 630626007376 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 630626007377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626007378 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 630626007379 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 630626007380 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 630626007381 putative RNA binding site [nucleotide binding]; other site 630626007382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007383 S-adenosylmethionine binding site [chemical binding]; other site 630626007384 heat shock protein HspQ; Provisional; Region: PRK14129 630626007385 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 630626007386 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 630626007387 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 630626007388 active site 630626007389 dimer interfaces [polypeptide binding]; other site 630626007390 catalytic residues [active] 630626007391 DNA helicase IV; Provisional; Region: helD; PRK11054 630626007392 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 630626007393 Part of AAA domain; Region: AAA_19; pfam13245 630626007394 Family description; Region: UvrD_C_2; pfam13538 630626007395 Predicted membrane protein [Function unknown]; Region: COG3304 630626007396 Domain of unknown function (DUF307); Region: DUF307; pfam03733 630626007397 Domain of unknown function (DUF307); Region: DUF307; pfam03733 630626007398 TIGR01666 family membrane protein; Region: YCCS 630626007399 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 630626007400 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 630626007401 TfoX N-terminal domain; Region: TfoX_N; pfam04993 630626007402 TfoX C-terminal domain; Region: TfoX_C; pfam04994 630626007403 SOS cell division inhibitor; Provisional; Region: PRK10595 630626007404 outer membrane protein A; Reviewed; Region: PRK10808 630626007405 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 630626007406 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 630626007407 ligand binding site [chemical binding]; other site 630626007408 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 630626007409 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 630626007410 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 630626007411 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 630626007412 active site 1 [active] 630626007413 dimer interface [polypeptide binding]; other site 630626007414 active site 2 [active] 630626007415 Ribosome modulation factor; Region: RMF; pfam04957 630626007416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 630626007417 Protein of unknown function (DUF330); Region: DUF330; pfam03886 630626007418 paraquat-inducible protein B; Provisional; Region: PRK10807 630626007419 mce related protein; Region: MCE; pfam02470 630626007420 mce related protein; Region: MCE; pfam02470 630626007421 mce related protein; Region: MCE; pfam02470 630626007422 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 630626007423 Paraquat-inducible protein A; Region: PqiA; pfam04403 630626007424 Paraquat-inducible protein A; Region: PqiA; pfam04403 630626007425 ABC transporter ATPase component; Reviewed; Region: PRK11147 630626007426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007428 Walker A/P-loop; other site 630626007429 Walker A/P-loop; other site 630626007430 ATP binding site [chemical binding]; other site 630626007431 ATP binding site [chemical binding]; other site 630626007432 Q-loop/lid; other site 630626007433 Q-loop/lid; other site 630626007434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626007435 ABC transporter signature motif; other site 630626007436 Walker B; other site 630626007437 D-loop; other site 630626007438 ABC transporter; Region: ABC_tran_2; pfam12848 630626007439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626007440 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 630626007441 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 630626007442 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 630626007443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007444 S-adenosylmethionine binding site [chemical binding]; other site 630626007445 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 630626007446 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 630626007447 MOSC domain; Region: MOSC; pfam03473 630626007448 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 630626007449 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626007450 catalytic loop [active] 630626007451 iron binding site [ion binding]; other site 630626007452 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 630626007453 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 630626007454 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 630626007455 quinone interaction residues [chemical binding]; other site 630626007456 active site 630626007457 catalytic residues [active] 630626007458 FMN binding site [chemical binding]; other site 630626007459 substrate binding site [chemical binding]; other site 630626007460 aminopeptidase N; Provisional; Region: pepN; PRK14015 630626007461 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 630626007462 active site 630626007463 Zn binding site [ion binding]; other site 630626007464 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 630626007465 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 630626007466 active site 630626007467 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 630626007468 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 630626007469 putative dimer interface [polypeptide binding]; other site 630626007470 putative anticodon binding site; other site 630626007471 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 630626007472 homodimer interface [polypeptide binding]; other site 630626007473 motif 1; other site 630626007474 motif 2; other site 630626007475 active site 630626007476 motif 3; other site 630626007477 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 630626007478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626007479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626007480 homodimer interface [polypeptide binding]; other site 630626007481 catalytic residue [active] 630626007482 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 630626007483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 630626007484 Peptidase M15; Region: Peptidase_M15_3; cl01194 630626007485 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626007486 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626007487 cell division protein MukB; Provisional; Region: mukB; PRK04863 630626007488 P-loop containing region of AAA domain; Region: AAA_29; cl17516 630626007489 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 630626007490 condesin subunit E; Provisional; Region: PRK05256 630626007491 condesin subunit F; Provisional; Region: PRK05260 630626007492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 630626007493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007494 S-adenosylmethionine binding site [chemical binding]; other site 630626007495 Uncharacterized conserved protein [Function unknown]; Region: COG1434 630626007496 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 630626007497 putative active site [active] 630626007498 hypothetical protein; Provisional; Region: PRK10593 630626007499 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 630626007500 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 630626007501 Ligand binding site; other site 630626007502 oligomer interface; other site 630626007503 Trm112p-like protein; Region: Trm112p; cl01066 630626007504 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 630626007505 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 630626007506 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 630626007507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626007508 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 630626007509 Walker A/P-loop; other site 630626007510 ATP binding site [chemical binding]; other site 630626007511 Q-loop/lid; other site 630626007512 ABC transporter signature motif; other site 630626007513 Walker B; other site 630626007514 D-loop; other site 630626007515 H-loop/switch region; other site 630626007516 ComEC family competence protein; Provisional; Region: PRK11539 630626007517 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 630626007518 Competence protein; Region: Competence; pfam03772 630626007519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 630626007520 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 630626007521 IHF dimer interface [polypeptide binding]; other site 630626007522 IHF - DNA interface [nucleotide binding]; other site 630626007523 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 630626007524 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 630626007525 RNA binding site [nucleotide binding]; other site 630626007526 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 630626007527 RNA binding site [nucleotide binding]; other site 630626007528 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 630626007529 RNA binding site [nucleotide binding]; other site 630626007530 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 630626007531 RNA binding site [nucleotide binding]; other site 630626007532 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 630626007533 RNA binding site [nucleotide binding]; other site 630626007534 cytidylate kinase; Provisional; Region: cmk; PRK00023 630626007535 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 630626007536 CMP-binding site; other site 630626007537 The sites determining sugar specificity; other site 630626007538 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 630626007539 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 630626007540 hinge; other site 630626007541 active site 630626007542 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 630626007543 homodimer interface [polypeptide binding]; other site 630626007544 substrate-cofactor binding pocket; other site 630626007545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626007546 catalytic residue [active] 630626007547 uncharacterized domain; Region: TIGR00702 630626007548 YcaO-like family; Region: YcaO; pfam02624 630626007549 formate transporter; Provisional; Region: PRK10805 630626007550 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 630626007551 Pyruvate formate lyase 1; Region: PFL1; cd01678 630626007552 coenzyme A binding site [chemical binding]; other site 630626007553 active site 630626007554 catalytic residues [active] 630626007555 glycine loop; other site 630626007556 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 630626007557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626007558 FeS/SAM binding site; other site 630626007559 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 630626007560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626007561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626007562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626007563 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 630626007564 putative effector binding pocket; other site 630626007565 putative dimerization interface [polypeptide binding]; other site 630626007566 putative MFS family transporter protein; Provisional; Region: PRK03633 630626007567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007568 putative substrate translocation pore; other site 630626007569 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 630626007570 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 630626007571 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 630626007572 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 630626007573 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 630626007574 putative [Fe4-S4] binding site [ion binding]; other site 630626007575 putative molybdopterin cofactor binding site [chemical binding]; other site 630626007576 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 630626007577 putative molybdopterin cofactor binding site; other site 630626007578 seryl-tRNA synthetase; Provisional; Region: PRK05431 630626007579 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 630626007580 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 630626007581 dimer interface [polypeptide binding]; other site 630626007582 active site 630626007583 motif 1; other site 630626007584 motif 2; other site 630626007585 motif 3; other site 630626007586 recombination factor protein RarA; Reviewed; Region: PRK13342 630626007587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626007588 Walker A motif; other site 630626007589 ATP binding site [chemical binding]; other site 630626007590 Walker B motif; other site 630626007591 arginine finger; other site 630626007592 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 630626007593 periplasmic chaperone LolA; Region: lolA; TIGR00547 630626007594 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 630626007595 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 630626007596 DNA translocase FtsK; Provisional; Region: PRK10263 630626007597 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 630626007598 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 630626007599 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 630626007600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626007601 putative DNA binding site [nucleotide binding]; other site 630626007602 putative Zn2+ binding site [ion binding]; other site 630626007603 AsnC family; Region: AsnC_trans_reg; pfam01037 630626007604 thioredoxin reductase; Provisional; Region: PRK10262 630626007605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 630626007606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626007607 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 630626007608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626007609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007610 Walker A/P-loop; other site 630626007611 ATP binding site [chemical binding]; other site 630626007612 Q-loop/lid; other site 630626007613 ABC transporter signature motif; other site 630626007614 Walker B; other site 630626007615 D-loop; other site 630626007616 H-loop/switch region; other site 630626007617 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 630626007618 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 630626007619 Walker A/P-loop; other site 630626007620 ATP binding site [chemical binding]; other site 630626007621 Q-loop/lid; other site 630626007622 ABC transporter signature motif; other site 630626007623 Walker B; other site 630626007624 D-loop; other site 630626007625 H-loop/switch region; other site 630626007626 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 630626007627 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 630626007628 rRNA binding site [nucleotide binding]; other site 630626007629 predicted 30S ribosome binding site; other site 630626007630 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 630626007631 Clp amino terminal domain; Region: Clp_N; pfam02861 630626007632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626007633 Walker A motif; other site 630626007634 ATP binding site [chemical binding]; other site 630626007635 Walker B motif; other site 630626007636 arginine finger; other site 630626007637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626007638 Walker A motif; other site 630626007639 ATP binding site [chemical binding]; other site 630626007640 Walker B motif; other site 630626007641 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 630626007642 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 630626007643 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626007644 DNA-binding site [nucleotide binding]; DNA binding site 630626007645 RNA-binding motif; other site 630626007646 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 630626007647 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 630626007648 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 630626007649 putative active site [active] 630626007650 putative metal-binding site [ion binding]; other site 630626007651 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 630626007652 amphipathic channel; other site 630626007653 Asn-Pro-Ala signature motifs; other site 630626007654 Predicted membrane protein [Function unknown]; Region: COG2431 630626007655 hybrid cluster protein; Provisional; Region: PRK05290 630626007656 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626007657 ACS interaction site; other site 630626007658 CODH interaction site; other site 630626007659 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 630626007660 hybrid metal cluster; other site 630626007661 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 630626007662 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 630626007663 FAD binding pocket [chemical binding]; other site 630626007664 FAD binding motif [chemical binding]; other site 630626007665 phosphate binding motif [ion binding]; other site 630626007666 beta-alpha-beta structure motif; other site 630626007667 NAD binding pocket [chemical binding]; other site 630626007668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626007669 catalytic loop [active] 630626007670 iron binding site [ion binding]; other site 630626007671 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 630626007672 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 630626007673 tetramer interface [polypeptide binding]; other site 630626007674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626007675 catalytic residue [active] 630626007676 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 630626007677 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 630626007678 putative NAD(P) binding site [chemical binding]; other site 630626007679 putative active site [active] 630626007680 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 630626007681 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 630626007682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626007683 NAD(P) binding site [chemical binding]; other site 630626007684 active site 630626007685 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 630626007686 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 630626007687 amidase catalytic site [active] 630626007688 Zn binding residues [ion binding]; other site 630626007689 substrate binding site [chemical binding]; other site 630626007690 hypothetical protein; Provisional; Region: PRK02877 630626007691 putative lipoprotein; Provisional; Region: PRK10533 630626007692 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 630626007693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007694 Walker A/P-loop; other site 630626007695 ATP binding site [chemical binding]; other site 630626007696 Q-loop/lid; other site 630626007697 ABC transporter signature motif; other site 630626007698 Walker B; other site 630626007699 D-loop; other site 630626007700 H-loop/switch region; other site 630626007701 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 630626007702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626007703 substrate binding pocket [chemical binding]; other site 630626007704 membrane-bound complex binding site; other site 630626007705 hinge residues; other site 630626007706 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626007707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007708 dimer interface [polypeptide binding]; other site 630626007709 conserved gate region; other site 630626007710 putative PBP binding loops; other site 630626007711 ABC-ATPase subunit interface; other site 630626007712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007713 dimer interface [polypeptide binding]; other site 630626007714 conserved gate region; other site 630626007715 putative PBP binding loops; other site 630626007716 ABC-ATPase subunit interface; other site 630626007717 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 630626007718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626007719 substrate binding pocket [chemical binding]; other site 630626007720 membrane-bound complex binding site; other site 630626007721 hinge residues; other site 630626007722 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 630626007723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007724 S-adenosylmethionine binding site [chemical binding]; other site 630626007725 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 630626007726 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 630626007727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007728 dimer interface [polypeptide binding]; other site 630626007729 conserved gate region; other site 630626007730 putative PBP binding loops; other site 630626007731 ABC-ATPase subunit interface; other site 630626007732 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 630626007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007734 dimer interface [polypeptide binding]; other site 630626007735 conserved gate region; other site 630626007736 putative PBP binding loops; other site 630626007737 ABC-ATPase subunit interface; other site 630626007738 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 630626007739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007740 Walker A/P-loop; other site 630626007741 ATP binding site [chemical binding]; other site 630626007742 Q-loop/lid; other site 630626007743 ABC transporter signature motif; other site 630626007744 Walker B; other site 630626007745 D-loop; other site 630626007746 H-loop/switch region; other site 630626007747 TOBE domain; Region: TOBE_2; pfam08402 630626007748 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 630626007749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 630626007750 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 630626007751 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 630626007752 RimK-like ATP-grasp domain; Region: RimK; pfam08443 630626007753 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 630626007754 dimer interface [polypeptide binding]; other site 630626007755 FMN binding site [chemical binding]; other site 630626007756 NADPH bind site [chemical binding]; other site 630626007757 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 630626007758 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 630626007759 putative transporter; Provisional; Region: PRK04972 630626007760 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 630626007761 TrkA-C domain; Region: TrkA_C; pfam02080 630626007762 TrkA-C domain; Region: TrkA_C; pfam02080 630626007763 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 630626007764 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 630626007765 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 630626007766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007769 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 630626007770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007771 putative substrate translocation pore; other site 630626007772 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 630626007773 active site 630626007774 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 630626007775 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 630626007776 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 630626007777 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 630626007778 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 630626007779 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 630626007780 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 630626007781 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 630626007782 putative C-terminal domain interface [polypeptide binding]; other site 630626007783 putative GSH binding site (G-site) [chemical binding]; other site 630626007784 putative dimer interface [polypeptide binding]; other site 630626007785 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 630626007786 putative N-terminal domain interface [polypeptide binding]; other site 630626007787 putative dimer interface [polypeptide binding]; other site 630626007788 putative substrate binding pocket (H-site) [chemical binding]; other site 630626007789 Biofilm formation protein (YliH/bssR); Region: YliH; cl08211 630626007790 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 630626007791 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 630626007792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626007793 FeS/SAM binding site; other site 630626007794 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 630626007795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007796 dimer interface [polypeptide binding]; other site 630626007797 conserved gate region; other site 630626007798 putative PBP binding loops; other site 630626007799 ABC-ATPase subunit interface; other site 630626007800 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 630626007801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007802 dimer interface [polypeptide binding]; other site 630626007803 conserved gate region; other site 630626007804 putative PBP binding loops; other site 630626007805 ABC-ATPase subunit interface; other site 630626007806 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 630626007807 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 630626007808 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 630626007809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626007810 Walker A/P-loop; other site 630626007811 ATP binding site [chemical binding]; other site 630626007812 Q-loop/lid; other site 630626007813 ABC transporter signature motif; other site 630626007814 Walker B; other site 630626007815 D-loop; other site 630626007816 H-loop/switch region; other site 630626007817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 630626007818 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 630626007819 Walker A/P-loop; other site 630626007820 ATP binding site [chemical binding]; other site 630626007821 Q-loop/lid; other site 630626007822 ABC transporter signature motif; other site 630626007823 Walker B; other site 630626007824 D-loop; other site 630626007825 H-loop/switch region; other site 630626007826 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 630626007827 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 630626007828 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 630626007829 dimer interface [polypeptide binding]; other site 630626007830 putative functional site; other site 630626007831 putative MPT binding site; other site 630626007832 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 630626007833 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 630626007834 ATP binding site [chemical binding]; other site 630626007835 substrate interface [chemical binding]; other site 630626007836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 630626007837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626007838 DNA binding site [nucleotide binding] 630626007839 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 630626007840 dimerization interface [polypeptide binding]; other site 630626007841 ligand binding site [chemical binding]; other site 630626007842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626007843 D-galactonate transporter; Region: 2A0114; TIGR00893 630626007844 putative substrate translocation pore; other site 630626007845 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 630626007846 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 630626007847 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 630626007848 putative active site [active] 630626007849 putative catalytic site [active] 630626007850 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 630626007851 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 630626007852 Nucleoside recognition; Region: Gate; pfam07670 630626007853 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 630626007854 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 630626007855 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 630626007856 active site 630626007857 metal binding site [ion binding]; metal-binding site 630626007858 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 630626007859 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 630626007860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626007861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626007862 Walker A/P-loop; other site 630626007863 ATP binding site [chemical binding]; other site 630626007864 ABC transporter signature motif; other site 630626007865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626007866 Walker B; other site 630626007867 ABC transporter; Region: ABC_tran_2; pfam12848 630626007868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626007869 L,D-transpeptidase; Provisional; Region: PRK10260 630626007870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 630626007871 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626007872 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 630626007873 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 630626007874 transmembrane helices; other site 630626007875 manganese transport regulator MntR; Provisional; Region: PRK11050 630626007876 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 630626007877 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 630626007878 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 630626007879 Sulfatase; Region: Sulfatase; pfam00884 630626007880 outer membrane protein X; Provisional; Region: ompX; PRK09408 630626007881 threonine and homoserine efflux system; Provisional; Region: PRK10532 630626007882 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 630626007883 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 630626007884 dimerization interface [polypeptide binding]; other site 630626007885 DPS ferroxidase diiron center [ion binding]; other site 630626007886 ion pore; other site 630626007887 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 630626007888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626007889 substrate binding pocket [chemical binding]; other site 630626007890 membrane-bound complex binding site; other site 630626007891 hinge residues; other site 630626007892 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626007893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626007894 dimer interface [polypeptide binding]; other site 630626007895 conserved gate region; other site 630626007896 putative PBP binding loops; other site 630626007897 ABC-ATPase subunit interface; other site 630626007898 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 630626007899 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 630626007900 Walker A/P-loop; other site 630626007901 ATP binding site [chemical binding]; other site 630626007902 Q-loop/lid; other site 630626007903 ABC transporter signature motif; other site 630626007904 Walker B; other site 630626007905 D-loop; other site 630626007906 H-loop/switch region; other site 630626007907 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 630626007908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007909 S-adenosylmethionine binding site [chemical binding]; other site 630626007910 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 630626007911 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 630626007912 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 630626007913 glycosyl transferase family protein; Provisional; Region: PRK08136 630626007914 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 630626007915 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 630626007916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 630626007917 DEAD_2; Region: DEAD_2; pfam06733 630626007918 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 630626007919 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 630626007920 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 630626007921 ATP binding site [chemical binding]; other site 630626007922 Mg++ binding site [ion binding]; other site 630626007923 motif III; other site 630626007924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626007925 nucleotide binding region [chemical binding]; other site 630626007926 ATP-binding site [chemical binding]; other site 630626007927 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 630626007928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626007929 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 630626007930 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 630626007931 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626007932 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626007933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 630626007934 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 630626007935 Walker A/P-loop; other site 630626007936 ATP binding site [chemical binding]; other site 630626007937 Q-loop/lid; other site 630626007938 ABC transporter signature motif; other site 630626007939 Walker B; other site 630626007940 D-loop; other site 630626007941 H-loop/switch region; other site 630626007942 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 630626007943 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 630626007944 Walker A/P-loop; other site 630626007945 ATP binding site [chemical binding]; other site 630626007946 Q-loop/lid; other site 630626007947 ABC transporter signature motif; other site 630626007948 Walker B; other site 630626007949 D-loop; other site 630626007950 H-loop/switch region; other site 630626007951 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626007952 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 630626007953 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626007954 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 630626007955 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 630626007956 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 630626007957 MoaE homodimer interface [polypeptide binding]; other site 630626007958 MoaD interaction [polypeptide binding]; other site 630626007959 active site residues [active] 630626007960 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 630626007961 MoaE interaction surface [polypeptide binding]; other site 630626007962 MoeB interaction surface [polypeptide binding]; other site 630626007963 thiocarboxylated glycine; other site 630626007964 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 630626007965 trimer interface [polypeptide binding]; other site 630626007966 dimer interface [polypeptide binding]; other site 630626007967 putative active site [active] 630626007968 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 630626007969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626007970 FeS/SAM binding site; other site 630626007971 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 630626007972 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 630626007973 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 630626007974 phosphate binding site [ion binding]; other site 630626007975 putative substrate binding pocket [chemical binding]; other site 630626007976 dimer interface [polypeptide binding]; other site 630626007977 excinuclease ABC subunit B; Provisional; Region: PRK05298 630626007978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626007979 ATP binding site [chemical binding]; other site 630626007980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626007981 nucleotide binding region [chemical binding]; other site 630626007982 ATP-binding site [chemical binding]; other site 630626007983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 630626007984 UvrB/uvrC motif; Region: UVR; pfam02151 630626007985 AAA domain; Region: AAA_26; pfam13500 630626007986 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 630626007987 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 630626007988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626007989 S-adenosylmethionine binding site [chemical binding]; other site 630626007990 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 630626007991 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 630626007992 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626007993 catalytic residue [active] 630626007994 biotin synthase; Provisional; Region: PRK15108 630626007995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626007996 FeS/SAM binding site; other site 630626007997 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 630626007998 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 630626007999 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626008000 inhibitor-cofactor binding pocket; inhibition site 630626008001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626008002 catalytic residue [active] 630626008003 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 630626008004 substrate binding site [chemical binding]; other site 630626008005 acyl-CoA thioesterase; Provisional; Region: PRK10531 630626008006 putative pectinesterase; Region: PLN02432; cl01911 630626008007 6-phosphogluconolactonase; Provisional; Region: PRK11028 630626008008 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 630626008009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626008010 active site 630626008011 motif I; other site 630626008012 motif II; other site 630626008013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626008014 Protein of unknown function (DUF796); Region: DUF796; cl01226 630626008015 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 630626008016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008017 Walker A/P-loop; other site 630626008018 ATP binding site [chemical binding]; other site 630626008019 Q-loop/lid; other site 630626008020 ABC transporter signature motif; other site 630626008021 Walker B; other site 630626008022 D-loop; other site 630626008023 H-loop/switch region; other site 630626008024 TOBE domain; Region: TOBE; cl01440 630626008025 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 630626008026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626008027 dimer interface [polypeptide binding]; other site 630626008028 conserved gate region; other site 630626008029 putative PBP binding loops; other site 630626008030 ABC-ATPase subunit interface; other site 630626008031 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 630626008032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626008033 substrate binding pocket [chemical binding]; other site 630626008034 membrane-bound complex binding site; other site 630626008035 hinge residues; other site 630626008036 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 630626008037 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 630626008038 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 630626008039 molybdenum-pterin binding domain; Region: Mop; TIGR00638 630626008040 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 630626008041 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 630626008042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008043 Walker A/P-loop; other site 630626008044 ATP binding site [chemical binding]; other site 630626008045 ABC transporter signature motif; other site 630626008046 Walker B; other site 630626008047 D-loop; other site 630626008048 H-loop/switch region; other site 630626008049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008050 Walker A/P-loop; other site 630626008051 ATP binding site [chemical binding]; other site 630626008052 Q-loop/lid; other site 630626008053 ABC transporter signature motif; other site 630626008054 Walker B; other site 630626008055 D-loop; other site 630626008056 H-loop/switch region; other site 630626008057 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 630626008058 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 630626008059 NAD binding site [chemical binding]; other site 630626008060 homodimer interface [polypeptide binding]; other site 630626008061 active site 630626008062 substrate binding site [chemical binding]; other site 630626008063 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 630626008064 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 630626008065 dimer interface [polypeptide binding]; other site 630626008066 active site 630626008067 galactokinase; Provisional; Region: PRK05101 630626008068 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 630626008069 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 630626008070 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 630626008071 active site 630626008072 catalytic residues [active] 630626008073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 630626008074 catalytic core [active] 630626008075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 630626008076 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 630626008077 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 630626008078 Cation efflux family; Region: Cation_efflux; cl00316 630626008079 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 630626008080 quinolinate synthetase; Provisional; Region: PRK09375 630626008081 tol-pal system protein YbgF; Provisional; Region: PRK10803 630626008082 Tetratricopeptide repeat; Region: TPR_6; pfam13174 630626008083 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 630626008084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 630626008085 ligand binding site [chemical binding]; other site 630626008086 translocation protein TolB; Provisional; Region: tolB; PRK03629 630626008087 TolB amino-terminal domain; Region: TolB_N; pfam04052 630626008088 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 630626008089 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 630626008090 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 630626008091 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 630626008092 TolA C-terminal; Region: TolA; pfam06519 630626008093 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 630626008094 colicin uptake protein TolR; Provisional; Region: PRK11024 630626008095 colicin uptake protein TolQ; Provisional; Region: PRK10801 630626008096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 630626008097 active site 630626008098 hypothetical protein; Provisional; Region: PRK10588 630626008099 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 630626008100 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 630626008101 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 630626008102 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 630626008103 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 630626008104 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 630626008105 CoA binding domain; Region: CoA_binding; smart00881 630626008106 CoA-ligase; Region: Ligase_CoA; pfam00549 630626008107 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 630626008108 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 630626008109 CoA-ligase; Region: Ligase_CoA; pfam00549 630626008110 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 630626008111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 630626008112 E3 interaction surface; other site 630626008113 lipoyl attachment site [posttranslational modification]; other site 630626008114 e3 binding domain; Region: E3_binding; pfam02817 630626008115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 630626008116 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 630626008117 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 630626008118 TPP-binding site [chemical binding]; other site 630626008119 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 630626008120 dimer interface [polypeptide binding]; other site 630626008121 PYR/PP interface [polypeptide binding]; other site 630626008122 TPP binding site [chemical binding]; other site 630626008123 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 630626008124 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 630626008125 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 630626008126 L-aspartate oxidase; Provisional; Region: PRK06175 630626008127 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 630626008128 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 630626008129 SdhC subunit interface [polypeptide binding]; other site 630626008130 proximal heme binding site [chemical binding]; other site 630626008131 cardiolipin binding site; other site 630626008132 Iron-sulfur protein interface; other site 630626008133 proximal quinone binding site [chemical binding]; other site 630626008134 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 630626008135 Iron-sulfur protein interface; other site 630626008136 proximal quinone binding site [chemical binding]; other site 630626008137 SdhD (CybS) interface [polypeptide binding]; other site 630626008138 proximal heme binding site [chemical binding]; other site 630626008139 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 630626008140 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 630626008141 dimer interface [polypeptide binding]; other site 630626008142 active site 630626008143 citrylCoA binding site [chemical binding]; other site 630626008144 NADH binding [chemical binding]; other site 630626008145 cationic pore residues; other site 630626008146 oxalacetate/citrate binding site [chemical binding]; other site 630626008147 coenzyme A binding site [chemical binding]; other site 630626008148 catalytic triad [active] 630626008149 endonuclease VIII; Provisional; Region: PRK10445 630626008150 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 630626008151 DNA binding site [nucleotide binding] 630626008152 catalytic residue [active] 630626008153 H2TH interface [polypeptide binding]; other site 630626008154 putative catalytic residues [active] 630626008155 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 630626008156 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 630626008157 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 630626008158 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 630626008159 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 630626008160 Uncharacterized conserved protein [Function unknown]; Region: COG0327 630626008161 metal-binding protein; Provisional; Region: PRK10799 630626008162 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 630626008163 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 630626008164 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 630626008165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 630626008166 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 630626008167 sensor protein KdpD; Provisional; Region: PRK10490 630626008168 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 630626008169 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 630626008170 Ligand Binding Site [chemical binding]; other site 630626008171 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 630626008172 GAF domain; Region: GAF_3; pfam13492 630626008173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626008174 dimer interface [polypeptide binding]; other site 630626008175 phosphorylation site [posttranslational modification] 630626008176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626008177 ATP binding site [chemical binding]; other site 630626008178 Mg2+ binding site [ion binding]; other site 630626008179 G-X-G motif; other site 630626008180 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 630626008181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626008182 active site 630626008183 phosphorylation site [posttranslational modification] 630626008184 intermolecular recognition site; other site 630626008185 dimerization interface [polypeptide binding]; other site 630626008186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626008187 DNA binding site [nucleotide binding] 630626008188 Predicted membrane protein [Function unknown]; Region: COG2510 630626008189 phosphoglucomutase; Validated; Region: PRK07564 630626008190 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 630626008191 active site 630626008192 substrate binding site [chemical binding]; other site 630626008193 metal binding site [ion binding]; metal-binding site 630626008194 replication initiation regulator SeqA; Provisional; Region: PRK11187 630626008195 acyl-CoA esterase; Provisional; Region: PRK10673 630626008196 PGAP1-like protein; Region: PGAP1; pfam07819 630626008197 LexA regulated protein; Provisional; Region: PRK11675 630626008198 flavodoxin FldA; Validated; Region: PRK09267 630626008199 ferric uptake regulator; Provisional; Region: fur; PRK09462 630626008200 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 630626008201 metal binding site 2 [ion binding]; metal-binding site 630626008202 putative DNA binding helix; other site 630626008203 metal binding site 1 [ion binding]; metal-binding site 630626008204 dimer interface [polypeptide binding]; other site 630626008205 structural Zn2+ binding site [ion binding]; other site 630626008206 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 630626008207 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 630626008208 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 630626008209 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 630626008210 active site 630626008211 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 630626008212 YbfN-like lipoprotein; Region: YbfN; pfam13982 630626008213 outer membrane porin, OprD family; Region: OprD; pfam03573 630626008214 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 630626008215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 630626008216 active site 630626008217 HIGH motif; other site 630626008218 nucleotide binding site [chemical binding]; other site 630626008219 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 630626008220 KMSKS motif; other site 630626008221 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 630626008222 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 630626008223 active site 630626008224 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 630626008225 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 630626008226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 630626008227 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 630626008228 active site turn [active] 630626008229 phosphorylation site [posttranslational modification] 630626008230 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 630626008231 HPr interaction site; other site 630626008232 glycerol kinase (GK) interaction site [polypeptide binding]; other site 630626008233 active site 630626008234 phosphorylation site [posttranslational modification] 630626008235 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 630626008236 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 630626008237 active site 630626008238 trimer interface [polypeptide binding]; other site 630626008239 allosteric site; other site 630626008240 active site lid [active] 630626008241 hexamer (dimer of trimers) interface [polypeptide binding]; other site 630626008242 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 630626008243 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 630626008244 active site 630626008245 dimer interface [polypeptide binding]; other site 630626008246 MarR family; Region: MarR; pfam01047 630626008247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 630626008248 ROK family; Region: ROK; pfam00480 630626008249 UMP phosphatase; Provisional; Region: PRK10444 630626008250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626008251 active site 630626008252 motif I; other site 630626008253 motif II; other site 630626008254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626008255 asparagine synthetase B; Provisional; Region: asnB; PRK09431 630626008256 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 630626008257 active site 630626008258 dimer interface [polypeptide binding]; other site 630626008259 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 630626008260 Ligand Binding Site [chemical binding]; other site 630626008261 Molecular Tunnel; other site 630626008262 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626008263 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 630626008264 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 630626008265 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 630626008266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626008267 FeS/SAM binding site; other site 630626008268 TRAM domain; Region: TRAM; pfam01938 630626008269 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 630626008270 PhoH-like protein; Region: PhoH; pfam02562 630626008271 metal-binding heat shock protein; Provisional; Region: PRK00016 630626008272 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 630626008273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 630626008274 Transporter associated domain; Region: CorC_HlyC; smart01091 630626008275 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 630626008276 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 630626008277 putative active site [active] 630626008278 catalytic triad [active] 630626008279 putative dimer interface [polypeptide binding]; other site 630626008280 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 630626008281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626008282 substrate binding pocket [chemical binding]; other site 630626008283 membrane-bound complex binding site; other site 630626008284 hinge residues; other site 630626008285 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626008286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626008287 dimer interface [polypeptide binding]; other site 630626008288 conserved gate region; other site 630626008289 putative PBP binding loops; other site 630626008290 ABC-ATPase subunit interface; other site 630626008291 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 630626008292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626008293 dimer interface [polypeptide binding]; other site 630626008294 conserved gate region; other site 630626008295 putative PBP binding loops; other site 630626008296 ABC-ATPase subunit interface; other site 630626008297 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 630626008298 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 630626008299 Walker A/P-loop; other site 630626008300 ATP binding site [chemical binding]; other site 630626008301 Q-loop/lid; other site 630626008302 ABC transporter signature motif; other site 630626008303 Walker B; other site 630626008304 D-loop; other site 630626008305 H-loop/switch region; other site 630626008306 hypothetical protein; Provisional; Region: PRK11032 630626008307 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 630626008308 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 630626008309 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 630626008310 HIGH motif; other site 630626008311 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 630626008312 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 630626008313 active site 630626008314 KMSKS motif; other site 630626008315 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 630626008316 tRNA binding surface [nucleotide binding]; other site 630626008317 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 630626008318 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 630626008319 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 630626008320 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 630626008321 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 630626008322 active site 630626008323 (T/H)XGH motif; other site 630626008324 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 630626008325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626008326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626008327 homodimer interface [polypeptide binding]; other site 630626008328 catalytic residue [active] 630626008329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 630626008330 catalytic core [active] 630626008331 ribosome-associated protein; Provisional; Region: PRK11538 630626008332 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 630626008333 penicillin-binding protein 2; Provisional; Region: PRK10795 630626008334 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 630626008335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 630626008336 cell wall shape-determining protein; Provisional; Region: PRK10794 630626008337 rare lipoprotein A; Provisional; Region: PRK10672 630626008338 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 630626008339 Sporulation related domain; Region: SPOR; pfam05036 630626008340 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 630626008341 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 630626008342 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 630626008343 hypothetical protein; Provisional; Region: PRK04998 630626008344 lipoate-protein ligase B; Provisional; Region: PRK14342 630626008345 lipoyl synthase; Provisional; Region: PRK05481 630626008346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626008347 FeS/SAM binding site; other site 630626008348 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 630626008349 Predicted amidohydrolase [General function prediction only]; Region: COG0388 630626008350 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 630626008351 putative active site [active] 630626008352 catalytic triad [active] 630626008353 putative dimer interface [polypeptide binding]; other site 630626008354 chromosome condensation membrane protein; Provisional; Region: PRK14196 630626008355 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626008356 DNA-binding site [nucleotide binding]; DNA binding site 630626008357 RNA-binding motif; other site 630626008358 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 630626008359 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 630626008360 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 630626008361 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 630626008362 B1 nucleotide binding pocket [chemical binding]; other site 630626008363 B2 nucleotide binding pocket [chemical binding]; other site 630626008364 CAS motifs; other site 630626008365 active site 630626008366 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 630626008367 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 630626008368 active site 630626008369 substrate binding site [chemical binding]; other site 630626008370 FMN binding site [chemical binding]; other site 630626008371 putative catalytic residues [active] 630626008372 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 630626008373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626008374 DNA-binding site [nucleotide binding]; DNA binding site 630626008375 FCD domain; Region: FCD; pfam07729 630626008376 L-lactate permease; Provisional; Region: PRK10420 630626008377 glycolate transporter; Provisional; Region: PRK09695 630626008378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626008379 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626008380 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626008381 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626008382 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 630626008383 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 630626008384 molybdopterin cofactor binding site; other site 630626008385 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 630626008386 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 630626008387 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 630626008388 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 630626008389 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 630626008390 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 630626008391 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 630626008392 trimer interface [polypeptide binding]; other site 630626008393 eyelet of channel; other site 630626008394 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 630626008395 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 630626008396 active site 630626008397 iron coordination sites [ion binding]; other site 630626008398 substrate binding pocket [chemical binding]; other site 630626008399 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 630626008400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626008401 dimer interface [polypeptide binding]; other site 630626008402 conserved gate region; other site 630626008403 putative PBP binding loops; other site 630626008404 ABC-ATPase subunit interface; other site 630626008405 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 630626008406 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 630626008407 Walker A/P-loop; other site 630626008408 ATP binding site [chemical binding]; other site 630626008409 Q-loop/lid; other site 630626008410 ABC transporter signature motif; other site 630626008411 Walker B; other site 630626008412 D-loop; other site 630626008413 H-loop/switch region; other site 630626008414 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 630626008415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626008416 substrate binding pocket [chemical binding]; other site 630626008417 membrane-bound complex binding site; other site 630626008418 hinge residues; other site 630626008419 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 630626008420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626008421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626008422 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 630626008423 putative substrate binding pocket [chemical binding]; other site 630626008424 putative dimerization interface [polypeptide binding]; other site 630626008425 Predicted permeases [General function prediction only]; Region: COG0679 630626008426 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 630626008427 EamA-like transporter family; Region: EamA; pfam00892 630626008428 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 630626008429 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 630626008430 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 630626008431 FMN binding site [chemical binding]; other site 630626008432 substrate binding site [chemical binding]; other site 630626008433 putative catalytic residue [active] 630626008434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 630626008435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 630626008436 DNA binding site [nucleotide binding] 630626008437 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 630626008438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008439 putative substrate translocation pore; other site 630626008440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008441 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 630626008442 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 630626008443 putative ligand binding site [chemical binding]; other site 630626008444 NAD binding site [chemical binding]; other site 630626008445 catalytic site [active] 630626008446 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 630626008447 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 630626008448 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 630626008449 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 630626008450 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 630626008451 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 630626008452 domain interface [polypeptide binding]; other site 630626008453 active site 630626008454 catalytic site [active] 630626008455 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 630626008456 domain interface [polypeptide binding]; other site 630626008457 active site 630626008458 catalytic site [active] 630626008459 exopolyphosphatase; Provisional; Region: PRK10854 630626008460 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626008461 nucleotide binding site [chemical binding]; other site 630626008462 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 630626008463 dimer interface [polypeptide binding]; other site 630626008464 FMN binding site [chemical binding]; other site 630626008465 NADPH bind site [chemical binding]; other site 630626008466 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 630626008467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626008468 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626008469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 630626008470 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 630626008471 Walker A/P-loop; other site 630626008472 ATP binding site [chemical binding]; other site 630626008473 Q-loop/lid; other site 630626008474 ABC transporter signature motif; other site 630626008475 Walker B; other site 630626008476 D-loop; other site 630626008477 H-loop/switch region; other site 630626008478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 630626008479 Walker A/P-loop; other site 630626008480 ATP binding site [chemical binding]; other site 630626008481 Q-loop/lid; other site 630626008482 ABC transporter signature motif; other site 630626008483 Walker B; other site 630626008484 D-loop; other site 630626008485 H-loop/switch region; other site 630626008486 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626008487 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 630626008488 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626008489 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 630626008490 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 630626008491 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 630626008492 putative active site [active] 630626008493 catalytic site [active] 630626008494 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 630626008495 Putative esterase; Region: Esterase; pfam00756 630626008496 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626008497 MarR family; Region: MarR_2; pfam12802 630626008498 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 630626008499 Predicted amidohydrolase [General function prediction only]; Region: COG0388 630626008500 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 630626008501 putative active site [active] 630626008502 catalytic triad [active] 630626008503 putative dimer interface [polypeptide binding]; other site 630626008504 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 630626008505 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 630626008506 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 630626008507 Cupin domain; Region: Cupin_2; pfam07883 630626008508 Cupin domain; Region: Cupin_2; pfam07883 630626008509 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 630626008510 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 630626008511 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 630626008512 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 630626008513 active site 630626008514 FMN binding site [chemical binding]; other site 630626008515 substrate binding site [chemical binding]; other site 630626008516 homotetramer interface [polypeptide binding]; other site 630626008517 catalytic residue [active] 630626008518 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 630626008519 active site 630626008520 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 630626008521 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 630626008522 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 630626008523 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 630626008524 dimer interface [polypeptide binding]; other site 630626008525 PYR/PP interface [polypeptide binding]; other site 630626008526 TPP binding site [chemical binding]; other site 630626008527 substrate binding site [chemical binding]; other site 630626008528 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 630626008529 TPP-binding site; other site 630626008530 benzoate transport; Region: 2A0115; TIGR00895 630626008531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008532 putative substrate translocation pore; other site 630626008533 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 630626008534 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 630626008535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626008536 MarR family; Region: MarR; pfam01047 630626008537 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 630626008538 active site 630626008539 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 630626008540 dimer interface [polypeptide binding]; other site 630626008541 non-prolyl cis peptide bond; other site 630626008542 insertion regions; other site 630626008543 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 630626008544 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 630626008545 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 630626008546 fructuronate transporter; Provisional; Region: PRK10034; cl15264 630626008547 gluconate transporter; Region: gntP; TIGR00791 630626008548 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 630626008549 lysine decarboxylase CadA; Provisional; Region: PRK15400 630626008550 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 630626008551 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 630626008552 homodimer interface [polypeptide binding]; other site 630626008553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626008554 catalytic residue [active] 630626008555 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 630626008556 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 630626008557 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 630626008558 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626008559 serine transporter; Region: stp; TIGR00814 630626008560 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 630626008561 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 630626008562 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 630626008563 Sulfatase; Region: Sulfatase; pfam00884 630626008564 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626008565 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 630626008566 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 630626008567 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 630626008568 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 630626008569 homodimer interface [polypeptide binding]; other site 630626008570 NADP binding site [chemical binding]; other site 630626008571 substrate binding site [chemical binding]; other site 630626008572 ribosome-associated protein; Provisional; Region: PRK11507 630626008573 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 630626008574 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 630626008575 active site 630626008576 HIGH motif; other site 630626008577 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 630626008578 KMSKS motif; other site 630626008579 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 630626008580 tRNA binding surface [nucleotide binding]; other site 630626008581 anticodon binding site; other site 630626008582 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 630626008583 substrate binding site [chemical binding]; other site 630626008584 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 630626008585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 630626008586 putative active site [active] 630626008587 putative metal binding site [ion binding]; other site 630626008588 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 630626008589 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 630626008590 ATP-grasp domain; Region: ATP-grasp; pfam02222 630626008591 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 630626008592 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 630626008593 active site residue [active] 630626008594 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 630626008595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 630626008596 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 630626008597 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 630626008598 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 630626008599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 630626008600 Walker A/P-loop; other site 630626008601 ATP binding site [chemical binding]; other site 630626008602 Q-loop/lid; other site 630626008603 ABC transporter signature motif; other site 630626008604 Walker B; other site 630626008605 D-loop; other site 630626008606 H-loop/switch region; other site 630626008607 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 630626008608 active site 630626008609 catalytic triad [active] 630626008610 oxyanion hole [active] 630626008611 switch loop; other site 630626008612 oxidoreductase; Provisional; Region: PRK08017 630626008613 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 630626008614 NADP binding site [chemical binding]; other site 630626008615 active site 630626008616 steroid binding site; other site 630626008617 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 630626008618 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 630626008619 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 630626008620 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 630626008621 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 630626008622 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 630626008623 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 630626008624 DNA binding residues [nucleotide binding] 630626008625 dimer interface [polypeptide binding]; other site 630626008626 copper binding site [ion binding]; other site 630626008627 YtxH-like protein; Region: YtxH; pfam12732 630626008628 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 630626008629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 630626008630 Soluble P-type ATPase [General function prediction only]; Region: COG4087 630626008631 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 630626008632 fructuronate transporter; Provisional; Region: PRK10034; cl15264 630626008633 Protein of unknown function (DUF406); Region: DUF406; pfam04175 630626008634 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 630626008635 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 630626008636 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 630626008637 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 630626008638 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 630626008639 carboxyltransferase (CT) interaction site; other site 630626008640 biotinylation site [posttranslational modification]; other site 630626008641 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 630626008642 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 630626008643 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 630626008644 hypothetical protein; Provisional; Region: PRK05463 630626008645 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 630626008646 putative active site [active] 630626008647 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 630626008648 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 630626008649 Transcriptional regulators [Transcription]; Region: GntR; COG1802 630626008650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626008651 DNA-binding site [nucleotide binding]; DNA binding site 630626008652 FCD domain; Region: FCD; pfam07729 630626008653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 630626008654 copper exporting ATPase; Provisional; Region: copA; PRK10671 630626008655 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 630626008656 metal-binding site [ion binding] 630626008657 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 630626008658 metal-binding site [ion binding] 630626008659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 630626008660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626008661 motif II; other site 630626008662 TraB family; Region: TraB; cl12050 630626008663 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 630626008664 putative deacylase active site [active] 630626008665 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 630626008666 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 630626008667 active site 630626008668 metal binding site [ion binding]; metal-binding site 630626008669 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 630626008670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626008672 putative substrate translocation pore; other site 630626008673 putative cation:proton antiport protein; Provisional; Region: PRK10669 630626008674 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 630626008675 TrkA-N domain; Region: TrkA_N; pfam02254 630626008676 inosine/guanosine kinase; Provisional; Region: PRK15074 630626008677 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 630626008678 acetyl esterase; Provisional; Region: PRK10162 630626008679 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 630626008680 ferrochelatase; Reviewed; Region: hemH; PRK00035 630626008681 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 630626008682 C-terminal domain interface [polypeptide binding]; other site 630626008683 active site 630626008684 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 630626008685 active site 630626008686 N-terminal domain interface [polypeptide binding]; other site 630626008687 adenylate kinase; Reviewed; Region: adk; PRK00279 630626008688 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 630626008689 AMP-binding site [chemical binding]; other site 630626008690 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 630626008691 heat shock protein 90; Provisional; Region: PRK05218 630626008692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626008693 ATP binding site [chemical binding]; other site 630626008694 Mg2+ binding site [ion binding]; other site 630626008695 G-X-G motif; other site 630626008696 recombination protein RecR; Reviewed; Region: recR; PRK00076 630626008697 RecR protein; Region: RecR; pfam02132 630626008698 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 630626008699 putative active site [active] 630626008700 putative metal-binding site [ion binding]; other site 630626008701 tetramer interface [polypeptide binding]; other site 630626008702 hypothetical protein; Validated; Region: PRK00153 630626008703 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 630626008704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626008705 Walker A motif; other site 630626008706 ATP binding site [chemical binding]; other site 630626008707 Walker B motif; other site 630626008708 arginine finger; other site 630626008709 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 630626008710 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 630626008711 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 630626008712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626008713 active site 630626008714 hypothetical protein; Provisional; Region: PRK10527 630626008715 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 630626008716 Protein of unknown function (DUF2496); Region: DUF2496; pfam10689 630626008717 hypothetical protein; Provisional; Region: PRK11281 630626008718 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 630626008719 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626008720 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 630626008721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626008722 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 630626008723 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 630626008724 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626008725 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626008726 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 630626008727 Hha toxicity attenuator; Provisional; Region: PRK10667 630626008728 gene expression modulator; Provisional; Region: PRK10945 630626008729 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 630626008730 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 630626008731 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 630626008732 DNA binding site [nucleotide binding] 630626008733 active site 630626008734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 630626008735 acyl-CoA thioesterase II; Provisional; Region: PRK10526 630626008736 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 630626008737 active site 630626008738 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 630626008739 catalytic triad [active] 630626008740 dimer interface [polypeptide binding]; other site 630626008741 ammonium transporter; Provisional; Region: PRK10666 630626008742 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 630626008743 Nitrogen regulatory protein P-II; Region: P-II; smart00938 630626008744 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 630626008745 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626008746 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 630626008747 Walker A/P-loop; other site 630626008748 ATP binding site [chemical binding]; other site 630626008749 Q-loop/lid; other site 630626008750 ABC transporter signature motif; other site 630626008751 Walker B; other site 630626008752 D-loop; other site 630626008753 H-loop/switch region; other site 630626008754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626008755 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 630626008756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008757 Walker A/P-loop; other site 630626008758 ATP binding site [chemical binding]; other site 630626008759 Q-loop/lid; other site 630626008760 ABC transporter signature motif; other site 630626008761 Walker B; other site 630626008762 D-loop; other site 630626008763 H-loop/switch region; other site 630626008764 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 630626008765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626008766 putative DNA binding site [nucleotide binding]; other site 630626008767 putative Zn2+ binding site [ion binding]; other site 630626008768 AsnC family; Region: AsnC_trans_reg; pfam01037 630626008769 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 630626008770 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 630626008771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626008772 catalytic residue [active] 630626008773 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 630626008774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 630626008775 active site 630626008776 motif I; other site 630626008777 motif II; other site 630626008778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 630626008779 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 630626008780 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 630626008781 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 630626008782 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 630626008783 Ligand Binding Site [chemical binding]; other site 630626008784 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 630626008785 active site 630626008786 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 630626008787 periplasmic folding chaperone; Provisional; Region: PRK10788 630626008788 SurA N-terminal domain; Region: SurA_N_3; cl07813 630626008789 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 630626008790 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 630626008791 IHF dimer interface [polypeptide binding]; other site 630626008792 IHF - DNA interface [nucleotide binding]; other site 630626008793 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 630626008794 Found in ATP-dependent protease La (LON); Region: LON; smart00464 630626008795 Found in ATP-dependent protease La (LON); Region: LON; smart00464 630626008796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626008797 Walker A motif; other site 630626008798 ATP binding site [chemical binding]; other site 630626008799 Walker B motif; other site 630626008800 arginine finger; other site 630626008801 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 630626008802 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 630626008803 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 630626008804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626008805 Walker A motif; other site 630626008806 ATP binding site [chemical binding]; other site 630626008807 Walker B motif; other site 630626008808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 630626008809 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 630626008810 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 630626008811 oligomer interface [polypeptide binding]; other site 630626008812 active site residues [active] 630626008813 trigger factor; Provisional; Region: tig; PRK01490 630626008814 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 630626008815 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 630626008816 transcriptional regulator BolA; Provisional; Region: PRK11628 630626008817 hypothetical protein; Provisional; Region: PRK11627 630626008818 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 630626008819 muropeptide transporter; Reviewed; Region: ampG; PRK11902 630626008820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008821 putative substrate translocation pore; other site 630626008822 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 630626008823 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 630626008824 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 630626008825 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 630626008826 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 630626008827 D-pathway; other site 630626008828 Putative ubiquinol binding site [chemical binding]; other site 630626008829 Low-spin heme (heme b) binding site [chemical binding]; other site 630626008830 Putative water exit pathway; other site 630626008831 Binuclear center (heme o3/CuB) [ion binding]; other site 630626008832 K-pathway; other site 630626008833 Putative proton exit pathway; other site 630626008834 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 630626008835 Subunit I/III interface [polypeptide binding]; other site 630626008836 Subunit III/IV interface [polypeptide binding]; other site 630626008837 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 630626008838 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 630626008839 UbiA prenyltransferase family; Region: UbiA; pfam01040 630626008840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626008841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 630626008842 putative substrate translocation pore; other site 630626008843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 630626008844 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 630626008845 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 630626008846 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 630626008847 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 630626008848 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 630626008849 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 630626008850 conserved cys residue [active] 630626008851 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 630626008852 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 630626008853 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 630626008854 Ligand Binding Site [chemical binding]; other site 630626008855 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 630626008856 active site residue [active] 630626008857 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 630626008858 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 630626008859 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 630626008860 substrate binding pocket [chemical binding]; other site 630626008861 chain length determination region; other site 630626008862 substrate-Mg2+ binding site; other site 630626008863 catalytic residues [active] 630626008864 aspartate-rich region 1; other site 630626008865 active site lid residues [active] 630626008866 aspartate-rich region 2; other site 630626008867 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 630626008868 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 630626008869 TPP-binding site; other site 630626008870 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 630626008871 PYR/PP interface [polypeptide binding]; other site 630626008872 dimer interface [polypeptide binding]; other site 630626008873 TPP binding site [chemical binding]; other site 630626008874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 630626008875 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 630626008876 tetramer interfaces [polypeptide binding]; other site 630626008877 binuclear metal-binding site [ion binding]; other site 630626008878 thiamine monophosphate kinase; Provisional; Region: PRK05731 630626008879 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 630626008880 ATP binding site [chemical binding]; other site 630626008881 dimerization interface [polypeptide binding]; other site 630626008882 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 630626008883 putative RNA binding site [nucleotide binding]; other site 630626008884 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 630626008885 homopentamer interface [polypeptide binding]; other site 630626008886 active site 630626008887 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 630626008888 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 630626008889 catalytic motif [active] 630626008890 Zn binding site [ion binding]; other site 630626008891 RibD C-terminal domain; Region: RibD_C; cl17279 630626008892 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 630626008893 ATP cone domain; Region: ATP-cone; pfam03477 630626008894 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 630626008895 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 630626008896 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 630626008897 trimer interface [polypeptide binding]; other site 630626008898 eyelet of channel; other site 630626008899 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 630626008900 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 630626008901 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 630626008902 Protein export membrane protein; Region: SecD_SecF; pfam02355 630626008903 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 630626008904 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 630626008905 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 630626008906 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 630626008907 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 630626008908 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 630626008909 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 630626008910 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 630626008911 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 630626008912 Protein of unknown function, DUF479; Region: DUF479; cl01203 630626008913 Uncharacterized conserved protein [Function unknown]; Region: COG1359 630626008914 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 630626008915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 630626008916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626008917 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 630626008918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626008919 dimerization interface [polypeptide binding]; other site 630626008920 putative proline-specific permease; Provisional; Region: proY; PRK10580 630626008921 Spore germination protein; Region: Spore_permease; cl17796 630626008922 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 630626008923 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 630626008924 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 630626008925 PAS domain; Region: PAS; smart00091 630626008926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626008927 dimer interface [polypeptide binding]; other site 630626008928 phosphorylation site [posttranslational modification] 630626008929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626008930 ATP binding site [chemical binding]; other site 630626008931 Mg2+ binding site [ion binding]; other site 630626008932 G-X-G motif; other site 630626008933 transcriptional regulator PhoB; Provisional; Region: PRK10161 630626008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626008935 active site 630626008936 phosphorylation site [posttranslational modification] 630626008937 intermolecular recognition site; other site 630626008938 dimerization interface [polypeptide binding]; other site 630626008939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626008940 DNA binding site [nucleotide binding] 630626008941 exonuclease subunit SbcD; Provisional; Region: PRK10966 630626008942 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 630626008943 active site 630626008944 metal binding site [ion binding]; metal-binding site 630626008945 DNA binding site [nucleotide binding] 630626008946 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 630626008947 exonuclease subunit SbcC; Provisional; Region: PRK10246 630626008948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008949 Walker A/P-loop; other site 630626008950 ATP binding site [chemical binding]; other site 630626008951 Q-loop/lid; other site 630626008952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626008953 ABC transporter signature motif; other site 630626008954 Walker B; other site 630626008955 D-loop; other site 630626008956 H-loop/switch region; other site 630626008957 fructokinase; Reviewed; Region: PRK09557 630626008958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626008959 nucleotide binding site [chemical binding]; other site 630626008960 recombination associated protein; Reviewed; Region: rdgC; PRK00321 630626008961 putative transposase OrfB; Reviewed; Region: PHA02517 630626008962 HTH-like domain; Region: HTH_21; pfam13276 630626008963 Integrase core domain; Region: rve; pfam00665 630626008964 Integrase core domain; Region: rve_2; pfam13333 630626008965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626008966 Helix-turn-helix domain; Region: HTH_28; pfam13518 630626008967 Helix-turn-helix domain; Region: HTH_28; pfam13518 630626008968 Pirin-related protein [General function prediction only]; Region: COG1741 630626008969 Pirin; Region: Pirin; pfam02678 630626008970 LysR family transcriptional regulator; Provisional; Region: PRK14997 630626008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626008972 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626008973 putative effector binding pocket; other site 630626008974 dimerization interface [polypeptide binding]; other site 630626008975 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 630626008976 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 630626008977 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 630626008978 ADP binding site [chemical binding]; other site 630626008979 magnesium binding site [ion binding]; other site 630626008980 putative shikimate binding site; other site 630626008981 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 630626008982 hypothetical protein; Validated; Region: PRK00124 630626008983 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 630626008984 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 630626008985 hypothetical protein; Provisional; Region: PRK11505 630626008986 psiF repeat; Region: PsiF_repeat; pfam07769 630626008987 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 630626008988 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 630626008989 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 630626008990 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 630626008991 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 630626008992 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 630626008993 microcin B17 transporter; Reviewed; Region: PRK11098 630626008994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 630626008995 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 630626008996 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 630626008997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626008998 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 630626008999 dimer interface [polypeptide binding]; other site 630626009000 active site 630626009001 Schiff base residues; other site 630626009002 phenylalanine transporter; Provisional; Region: PRK10249 630626009003 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626009004 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 630626009005 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 630626009006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626009007 dimer interface [polypeptide binding]; other site 630626009008 conserved gate region; other site 630626009009 putative PBP binding loops; other site 630626009010 ABC-ATPase subunit interface; other site 630626009011 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 630626009012 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 630626009013 Walker A/P-loop; other site 630626009014 ATP binding site [chemical binding]; other site 630626009015 Q-loop/lid; other site 630626009016 ABC transporter signature motif; other site 630626009017 Walker B; other site 630626009018 D-loop; other site 630626009019 H-loop/switch region; other site 630626009020 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 630626009021 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 630626009022 active site 630626009023 dimer interface [polypeptide binding]; other site 630626009024 non-prolyl cis peptide bond; other site 630626009025 insertion regions; other site 630626009026 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 630626009027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626009028 substrate binding pocket [chemical binding]; other site 630626009029 membrane-bound complex binding site; other site 630626009030 putative alcohol dehydrogenase; Provisional; Region: PRK09860 630626009031 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 630626009032 dimer interface [polypeptide binding]; other site 630626009033 active site 630626009034 metal binding site [ion binding]; metal-binding site 630626009035 hypothetical protein; Provisional; Region: PRK09956 630626009036 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 630626009037 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 630626009038 potential frameshift: common BLAST hit: gi|152971609|ref|YP_001336718.1| ferric enterobactin/colicins B/D outer membrane porin 630626009039 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 630626009040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 630626009041 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 630626009042 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 630626009043 metal binding site [ion binding]; metal-binding site 630626009044 putative dimer interface [polypeptide binding]; other site 630626009045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626009046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 630626009047 substrate binding pocket [chemical binding]; other site 630626009048 membrane-bound complex binding site; other site 630626009049 hinge residues; other site 630626009050 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626009051 molybdopterin cofactor binding site; other site 630626009052 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 630626009053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626009054 dimerization interface [polypeptide binding]; other site 630626009055 putative DNA binding site [nucleotide binding]; other site 630626009056 putative Zn2+ binding site [ion binding]; other site 630626009057 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 630626009058 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 630626009059 FMN binding site [chemical binding]; other site 630626009060 active site 630626009061 substrate binding site [chemical binding]; other site 630626009062 catalytic residue [active] 630626009063 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 630626009064 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 630626009065 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 630626009066 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 630626009067 Phage Tail Collar Domain; Region: Collar; pfam07484 630626009068 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 630626009069 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 630626009070 Phage protein GP46; Region: GP46; pfam07409 630626009071 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 630626009072 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 630626009073 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 630626009074 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 630626009075 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 630626009076 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 630626009077 Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518 630626009078 Phage tail tube protein; Region: Tail_tube; pfam10618 630626009079 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 630626009080 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 630626009081 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 630626009082 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 630626009083 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 630626009084 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124 630626009085 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 630626009086 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 630626009087 Protein of unknown function (DUF935); Region: DUF935; pfam06074 630626009088 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 630626009089 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 630626009090 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 630626009091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 630626009092 dimerization interface [polypeptide binding]; other site 630626009093 putative DNA binding site [nucleotide binding]; other site 630626009094 putative Zn2+ binding site [ion binding]; other site 630626009095 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 630626009096 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 630626009097 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 630626009098 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 630626009099 Mor transcription activator family; Region: Mor; pfam08765 630626009100 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 630626009101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 630626009102 metal binding site [ion binding]; metal-binding site 630626009103 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 630626009104 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 630626009105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 630626009106 Walker A motif; other site 630626009107 ATP binding site [chemical binding]; other site 630626009108 Walker B motif; other site 630626009109 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 630626009110 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 630626009111 Integrase core domain; Region: rve; pfam00665 630626009112 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 630626009113 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 630626009114 Predicted transcriptional regulator [Transcription]; Region: COG2932 630626009115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626009116 non-specific DNA binding site [nucleotide binding]; other site 630626009117 salt bridge; other site 630626009118 sequence-specific DNA binding site [nucleotide binding]; other site 630626009119 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 630626009120 Catalytic site [active] 630626009121 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 630626009122 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 630626009123 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 630626009124 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 630626009125 alpha-beta subunit interface [polypeptide binding]; other site 630626009126 alpha-gamma subunit interface [polypeptide binding]; other site 630626009127 active site 630626009128 substrate and K+ binding site; other site 630626009129 K+ binding site [ion binding]; other site 630626009130 cobalamin binding site [chemical binding]; other site 630626009131 Domain of unknown function (DUF336); Region: DUF336; pfam03928 630626009132 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 630626009133 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 630626009134 dimer interface [polypeptide binding]; other site 630626009135 active site 630626009136 metal binding site [ion binding]; metal-binding site 630626009137 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 630626009138 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 630626009139 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 630626009140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626009141 putative active site [active] 630626009142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626009143 Walker A motif; other site 630626009144 ATP binding site [chemical binding]; other site 630626009145 Walker B motif; other site 630626009146 arginine finger; other site 630626009147 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 630626009148 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 630626009149 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 630626009150 dimer interface [polypeptide binding]; other site 630626009151 active site 630626009152 metal binding site [ion binding]; metal-binding site 630626009153 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 630626009154 Dak1 domain; Region: Dak1; pfam02733 630626009155 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 630626009156 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 630626009157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 630626009158 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 630626009159 dimerization domain swap beta strand [polypeptide binding]; other site 630626009160 regulatory protein interface [polypeptide binding]; other site 630626009161 active site 630626009162 regulatory phosphorylation site [posttranslational modification]; other site 630626009163 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 630626009164 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 630626009165 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 630626009166 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 630626009167 DAK2 domain; Region: Dak2; pfam02734 630626009168 alkaline phosphatase; Provisional; Region: PRK10518 630626009169 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 630626009170 dimer interface [polypeptide binding]; other site 630626009171 active site 630626009172 Predicted transcriptional regulator [Transcription]; Region: COG4190 630626009173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626009174 putative DNA binding site [nucleotide binding]; other site 630626009175 putative Zn2+ binding site [ion binding]; other site 630626009176 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 630626009177 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 630626009178 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 630626009179 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 630626009180 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 630626009181 catalytic residues [active] 630626009182 central insert; other site 630626009183 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 630626009184 CcmE; Region: CcmE; cl00994 630626009185 Heme exporter protein D (CcmD); Region: CcmD; cl11475 630626009186 heme exporter protein CcmC; Region: ccmC; TIGR01191 630626009187 heme exporter protein CcmB; Region: ccmB; TIGR01190 630626009188 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 630626009189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626009190 Walker A/P-loop; other site 630626009191 ATP binding site [chemical binding]; other site 630626009192 Q-loop/lid; other site 630626009193 ABC transporter signature motif; other site 630626009194 Walker B; other site 630626009195 D-loop; other site 630626009196 H-loop/switch region; other site 630626009197 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 630626009198 Cytochrome c; Region: Cytochrom_C; cl11414 630626009199 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 630626009200 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 630626009201 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 630626009202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 630626009203 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 630626009204 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 630626009205 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626009206 Walker A/P-loop; other site 630626009207 ATP binding site [chemical binding]; other site 630626009208 Q-loop/lid; other site 630626009209 ABC transporter signature motif; other site 630626009210 Walker B; other site 630626009211 D-loop; other site 630626009212 H-loop/switch region; other site 630626009213 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 630626009214 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 630626009215 putative ligand binding residues [chemical binding]; other site 630626009216 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626009217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626009218 ABC-ATPase subunit interface; other site 630626009219 dimer interface [polypeptide binding]; other site 630626009220 putative PBP binding regions; other site 630626009221 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626009222 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 630626009223 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 630626009224 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 630626009225 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 630626009226 multidrug resistance protein MdtN; Provisional; Region: PRK10476 630626009227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626009228 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626009229 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 630626009230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626009231 DNA-binding site [nucleotide binding]; DNA binding site 630626009232 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626009233 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 630626009234 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 630626009235 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626009236 inhibitor-cofactor binding pocket; inhibition site 630626009237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626009238 catalytic residue [active] 630626009239 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 630626009240 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 630626009241 tetramerization interface [polypeptide binding]; other site 630626009242 NAD(P) binding site [chemical binding]; other site 630626009243 catalytic residues [active] 630626009244 Predicted dehydrogenase [General function prediction only]; Region: COG0579 630626009245 hydroxyglutarate oxidase; Provisional; Region: PRK11728 630626009246 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 630626009247 substrate binding pocket [chemical binding]; other site 630626009248 active site 630626009249 iron coordination sites [ion binding]; other site 630626009250 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 630626009251 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 630626009252 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 630626009253 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 630626009254 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 630626009255 CT1975-like protein; Region: Cas_CT1975; pfam09344 630626009256 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 630626009257 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 630626009258 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 630626009259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626009260 non-specific DNA binding site [nucleotide binding]; other site 630626009261 salt bridge; other site 630626009262 sequence-specific DNA binding site [nucleotide binding]; other site 630626009263 helicase Cas3; Provisional; Region: PRK09694 630626009264 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 630626009265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 630626009266 cystathionine beta-lyase; Provisional; Region: PRK05967 630626009267 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 630626009268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626009269 catalytic residue [active] 630626009270 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 630626009271 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 630626009272 HTH-like domain; Region: HTH_21; pfam13276 630626009273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626009274 Integrase core domain; Region: rve; pfam00665 630626009275 Integrase core domain; Region: rve_3; pfam13683 630626009276 Transposase; Region: HTH_Tnp_1; pfam01527 630626009277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626009278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626009279 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626009280 putative effector binding pocket; other site 630626009281 dimerization interface [polypeptide binding]; other site 630626009282 TPR repeat; Region: TPR_11; pfam13414 630626009283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626009284 binding surface 630626009285 TPR motif; other site 630626009286 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 630626009287 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 630626009288 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 630626009289 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 630626009290 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 630626009291 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 630626009292 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 630626009293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 630626009294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626009295 non-specific DNA binding site [nucleotide binding]; other site 630626009296 salt bridge; other site 630626009297 sequence-specific DNA binding site [nucleotide binding]; other site 630626009298 Cupin domain; Region: Cupin_2; pfam07883 630626009299 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 630626009300 B3/4 domain; Region: B3_4; pfam03483 630626009301 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 630626009302 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 630626009303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626009304 DNA-binding site [nucleotide binding]; DNA binding site 630626009305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626009306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626009307 homodimer interface [polypeptide binding]; other site 630626009308 catalytic residue [active] 630626009309 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 630626009310 Predicted membrane protein [Function unknown]; Region: COG2364 630626009311 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 630626009312 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 630626009313 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 630626009314 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 630626009315 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 630626009316 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 630626009317 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 630626009318 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 630626009319 metal ion-dependent adhesion site (MIDAS); other site 630626009320 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 630626009321 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 630626009322 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 630626009323 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 630626009324 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626009325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 630626009326 Walker A/P-loop; other site 630626009327 ATP binding site [chemical binding]; other site 630626009328 Q-loop/lid; other site 630626009329 ABC transporter signature motif; other site 630626009330 Walker B; other site 630626009331 D-loop; other site 630626009332 H-loop/switch region; other site 630626009333 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 630626009334 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626009335 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626009336 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 630626009337 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 630626009338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 630626009339 metal binding site [ion binding]; metal-binding site 630626009340 active site 630626009341 I-site; other site 630626009342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 630626009343 Predicted membrane protein [Function unknown]; Region: COG2259 630626009344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 630626009345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 630626009346 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 630626009347 acyl-activating enzyme (AAE) consensus motif; other site 630626009348 acyl-activating enzyme (AAE) consensus motif; other site 630626009349 putative AMP binding site [chemical binding]; other site 630626009350 putative active site [active] 630626009351 putative CoA binding site [chemical binding]; other site 630626009352 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 630626009353 Coenzyme A transferase; Region: CoA_trans; smart00882 630626009354 Coenzyme A transferase; Region: CoA_trans; cl17247 630626009355 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 630626009356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626009357 NAD(P) binding site [chemical binding]; other site 630626009358 active site 630626009359 putative acyltransferase; Provisional; Region: PRK05790 630626009360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626009361 dimer interface [polypeptide binding]; other site 630626009362 active site 630626009363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626009364 putative substrate translocation pore; other site 630626009365 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 630626009366 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 630626009367 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 630626009368 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 630626009369 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 630626009370 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626009371 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 630626009372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 630626009373 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 630626009374 Walker A/P-loop; other site 630626009375 ATP binding site [chemical binding]; other site 630626009376 Q-loop/lid; other site 630626009377 ABC transporter signature motif; other site 630626009378 Walker B; other site 630626009379 D-loop; other site 630626009380 H-loop/switch region; other site 630626009381 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 630626009382 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 630626009383 putative heme binding site [chemical binding]; other site 630626009384 putative substrate binding site [chemical binding]; other site 630626009385 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 630626009386 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626009387 DNA-binding site [nucleotide binding]; DNA binding site 630626009388 RNA-binding motif; other site 630626009389 HPP family; Region: HPP; pfam04982 630626009390 Predicted permeases [General function prediction only]; Region: COG0679 630626009391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626009392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626009393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626009394 dimerization interface [polypeptide binding]; other site 630626009395 Predicted acetyltransferase [General function prediction only]; Region: COG2388 630626009396 Uncharacterized conserved protein [Function unknown]; Region: COG3592 630626009397 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 630626009398 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 630626009399 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 630626009400 putative catalytic cysteine [active] 630626009401 gamma-glutamyl kinase; Provisional; Region: PRK05429 630626009402 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 630626009403 nucleotide binding site [chemical binding]; other site 630626009404 homotetrameric interface [polypeptide binding]; other site 630626009405 putative phosphate binding site [ion binding]; other site 630626009406 putative allosteric binding site; other site 630626009407 PUA domain; Region: PUA; pfam01472 630626009408 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 630626009409 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 630626009410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626009411 active site 630626009412 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 630626009413 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 630626009414 metal binding site [ion binding]; metal-binding site 630626009415 dimer interface [polypeptide binding]; other site 630626009416 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 630626009417 active site 630626009418 DNA polymerase IV; Validated; Region: PRK02406 630626009419 DNA binding site [nucleotide binding] 630626009420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 630626009421 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 630626009422 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626009423 catalytic loop [active] 630626009424 iron binding site [ion binding]; other site 630626009425 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 630626009426 FAD binding pocket [chemical binding]; other site 630626009427 FAD binding motif [chemical binding]; other site 630626009428 phosphate binding motif [ion binding]; other site 630626009429 beta-alpha-beta structure motif; other site 630626009430 NAD binding pocket [chemical binding]; other site 630626009431 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 630626009432 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 630626009433 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 630626009434 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 630626009435 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 630626009436 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 630626009437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 630626009438 E3 interaction surface; other site 630626009439 lipoyl attachment site [posttranslational modification]; other site 630626009440 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 630626009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 630626009442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 630626009443 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 630626009444 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 630626009445 putative active site [active] 630626009446 putative dimer interface [polypeptide binding]; other site 630626009447 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 630626009448 dimer interface [polypeptide binding]; other site 630626009449 active site 630626009450 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 630626009451 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 630626009452 active site 630626009453 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 630626009454 C-lysozyme inhibitor; Provisional; Region: PRK09993 630626009455 C-N hydrolase family amidase; Provisional; Region: PRK10438 630626009456 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 630626009457 putative active site [active] 630626009458 catalytic triad [active] 630626009459 dimer interface [polypeptide binding]; other site 630626009460 multimer interface [polypeptide binding]; other site 630626009461 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 630626009462 Na binding site [ion binding]; other site 630626009463 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 630626009464 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 630626009465 major curlin subunit; Provisional; Region: csgA; PRK10051 630626009466 Curlin associated repeat; Region: Curlin_rpt; pfam07012 630626009467 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 630626009468 Curlin associated repeat; Region: Curlin_rpt; pfam07012 630626009469 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 630626009470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 630626009471 DNA binding residues [nucleotide binding] 630626009472 dimerization interface [polypeptide binding]; other site 630626009473 Curli assembly protein CsgE; Region: CsgE; cl08115 630626009474 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 630626009475 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 630626009476 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 630626009477 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 630626009478 active site 630626009479 catalytic site [active] 630626009480 substrate binding site [chemical binding]; other site 630626009481 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 630626009482 RNA/DNA hybrid binding site [nucleotide binding]; other site 630626009483 active site 630626009484 Methyltransferase domain; Region: Methyltransf_11; pfam08241 630626009485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 630626009486 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 630626009487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626009488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626009489 catalytic residue [active] 630626009490 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626009491 hypothetical protein; Provisional; Region: PRK05421 630626009492 putative catalytic site [active] 630626009493 putative metal binding site [ion binding]; other site 630626009494 putative phosphate binding site [ion binding]; other site 630626009495 putative catalytic site [active] 630626009496 putative phosphate binding site [ion binding]; other site 630626009497 putative metal binding site [ion binding]; other site 630626009498 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 630626009499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626009500 putative substrate translocation pore; other site 630626009501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626009502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626009503 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 630626009504 putative effector binding pocket; other site 630626009505 dimerization interface [polypeptide binding]; other site 630626009506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 630626009507 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 630626009508 active site 630626009509 catalytic tetrad [active] 630626009510 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 630626009511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626009512 active site 630626009513 motif I; other site 630626009514 motif II; other site 630626009515 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 630626009516 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 630626009517 Walker A/P-loop; other site 630626009518 ATP binding site [chemical binding]; other site 630626009519 Q-loop/lid; other site 630626009520 ABC transporter signature motif; other site 630626009521 Walker B; other site 630626009522 D-loop; other site 630626009523 H-loop/switch region; other site 630626009524 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 630626009525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626009526 dimer interface [polypeptide binding]; other site 630626009527 conserved gate region; other site 630626009528 ABC-ATPase subunit interface; other site 630626009529 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 630626009530 lipoprotein, YaeC family; Region: TIGR00363 630626009531 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 630626009532 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 630626009533 homodimer interaction site [polypeptide binding]; other site 630626009534 cofactor binding site; other site 630626009535 prolyl-tRNA synthetase; Provisional; Region: PRK09194 630626009536 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 630626009537 dimer interface [polypeptide binding]; other site 630626009538 motif 1; other site 630626009539 active site 630626009540 motif 2; other site 630626009541 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 630626009542 putative deacylase active site [active] 630626009543 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 630626009544 active site 630626009545 motif 3; other site 630626009546 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 630626009547 anticodon binding site; other site 630626009548 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 630626009549 NlpE N-terminal domain; Region: NlpE; pfam04170 630626009550 hypothetical protein; Provisional; Region: PRK09256 630626009551 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 630626009552 YaeQ protein; Region: YaeQ; cl01913 630626009553 hypothetical protein; Provisional; Region: PRK04964 630626009554 Rho-binding antiterminator; Provisional; Region: PRK11625 630626009555 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 630626009556 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 630626009557 Ligand Binding Site [chemical binding]; other site 630626009558 TilS substrate binding domain; Region: TilS; pfam09179 630626009559 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 630626009560 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 630626009561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626009562 putative substrate translocation pore; other site 630626009563 POT family; Region: PTR2; cl17359 630626009564 lysine decarboxylase CadA; Provisional; Region: PRK15400 630626009565 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 630626009566 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 630626009567 homodimer interface [polypeptide binding]; other site 630626009568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626009569 catalytic residue [active] 630626009570 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 630626009571 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 630626009572 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 630626009573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626009574 DNA binding site [nucleotide binding] 630626009575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 630626009576 binding surface 630626009577 TPR motif; other site 630626009578 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 630626009579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 630626009580 putative metal binding site [ion binding]; other site 630626009581 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 630626009582 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 630626009583 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 630626009584 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 630626009585 putative active site [active] 630626009586 putative PHP Thumb interface [polypeptide binding]; other site 630626009587 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 630626009588 generic binding surface II; other site 630626009589 generic binding surface I; other site 630626009590 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 630626009591 RNA/DNA hybrid binding site [nucleotide binding]; other site 630626009592 active site 630626009593 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 630626009594 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 630626009595 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 630626009596 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 630626009597 active site 630626009598 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 630626009599 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 630626009600 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 630626009601 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 630626009602 trimer interface [polypeptide binding]; other site 630626009603 active site 630626009604 UDP-GlcNAc binding site [chemical binding]; other site 630626009605 lipid binding site [chemical binding]; lipid-binding site 630626009606 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 630626009607 periplasmic chaperone; Provisional; Region: PRK10780 630626009608 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 630626009609 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 630626009610 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 630626009611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 630626009612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 630626009613 Surface antigen; Region: Bac_surface_Ag; pfam01103 630626009614 zinc metallopeptidase RseP; Provisional; Region: PRK10779 630626009615 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 630626009616 active site 630626009617 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 630626009618 protein binding site [polypeptide binding]; other site 630626009619 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 630626009620 protein binding site [polypeptide binding]; other site 630626009621 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 630626009622 putative substrate binding region [chemical binding]; other site 630626009623 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 630626009624 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 630626009625 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 630626009626 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 630626009627 catalytic residue [active] 630626009628 putative FPP diphosphate binding site; other site 630626009629 putative FPP binding hydrophobic cleft; other site 630626009630 dimer interface [polypeptide binding]; other site 630626009631 putative IPP diphosphate binding site; other site 630626009632 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 630626009633 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 630626009634 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 630626009635 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 630626009636 ribosome recycling factor; Reviewed; Region: frr; PRK00083 630626009637 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 630626009638 hinge region; other site 630626009639 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 630626009640 putative nucleotide binding site [chemical binding]; other site 630626009641 uridine monophosphate binding site [chemical binding]; other site 630626009642 homohexameric interface [polypeptide binding]; other site 630626009643 elongation factor Ts; Provisional; Region: tsf; PRK09377 630626009644 UBA/TS-N domain; Region: UBA; pfam00627 630626009645 Elongation factor TS; Region: EF_TS; pfam00889 630626009646 Elongation factor TS; Region: EF_TS; pfam00889 630626009647 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 630626009648 rRNA interaction site [nucleotide binding]; other site 630626009649 S8 interaction site; other site 630626009650 putative laminin-1 binding site; other site 630626009651 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 630626009652 active site 630626009653 PII uridylyl-transferase; Provisional; Region: PRK05007 630626009654 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 630626009655 metal binding triad; other site 630626009656 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 630626009657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626009658 Zn2+ binding site [ion binding]; other site 630626009659 Mg2+ binding site [ion binding]; other site 630626009660 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 630626009661 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 630626009662 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 630626009663 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 630626009664 trimer interface [polypeptide binding]; other site 630626009665 active site 630626009666 substrate binding site [chemical binding]; other site 630626009667 CoA binding site [chemical binding]; other site 630626009668 hypothetical protein; Provisional; Region: PRK13677 630626009669 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 630626009670 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 630626009671 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 630626009672 serine endoprotease; Provisional; Region: PRK10942 630626009673 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 630626009674 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 630626009675 protein binding site [polypeptide binding]; other site 630626009676 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 630626009677 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 630626009678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626009679 Zn2+ binding site [ion binding]; other site 630626009680 Mg2+ binding site [ion binding]; other site 630626009681 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 630626009682 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 630626009683 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 630626009684 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 630626009685 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 630626009686 cobalamin binding residues [chemical binding]; other site 630626009687 putative BtuC binding residues; other site 630626009688 dimer interface [polypeptide binding]; other site 630626009689 hypothetical protein; Provisional; Region: PRK10578 630626009690 UPF0126 domain; Region: UPF0126; pfam03458 630626009691 UPF0126 domain; Region: UPF0126; pfam03458 630626009692 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 630626009693 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 630626009694 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 630626009695 Cl- selectivity filter; other site 630626009696 Cl- binding residues [ion binding]; other site 630626009697 pore gating glutamate residue; other site 630626009698 dimer interface [polypeptide binding]; other site 630626009699 H+/Cl- coupling transport residue; other site 630626009700 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 630626009701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 630626009702 inhibitor-cofactor binding pocket; inhibition site 630626009703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626009704 catalytic residue [active] 630626009705 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626009706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626009707 ABC-ATPase subunit interface; other site 630626009708 dimer interface [polypeptide binding]; other site 630626009709 putative PBP binding regions; other site 630626009710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626009711 ABC-ATPase subunit interface; other site 630626009712 dimer interface [polypeptide binding]; other site 630626009713 putative PBP binding regions; other site 630626009714 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 630626009715 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 630626009716 siderophore binding site; other site 630626009717 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 630626009718 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626009719 Walker A/P-loop; other site 630626009720 ATP binding site [chemical binding]; other site 630626009721 Q-loop/lid; other site 630626009722 ABC transporter signature motif; other site 630626009723 Walker B; other site 630626009724 D-loop; other site 630626009725 H-loop/switch region; other site 630626009726 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 630626009727 Transglycosylase; Region: Transgly; pfam00912 630626009728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 630626009729 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 630626009730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626009731 ATP binding site [chemical binding]; other site 630626009732 putative Mg++ binding site [ion binding]; other site 630626009733 helicase superfamily c-terminal domain; Region: HELICc; smart00490 630626009734 nucleotide binding region [chemical binding]; other site 630626009735 ATP-binding site [chemical binding]; other site 630626009736 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 630626009737 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 630626009738 2'-5' RNA ligase; Provisional; Region: PRK15124 630626009739 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 630626009740 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 630626009741 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 630626009742 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 630626009743 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 630626009744 active site 630626009745 nucleotide binding site [chemical binding]; other site 630626009746 HIGH motif; other site 630626009747 KMSKS motif; other site 630626009748 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 630626009749 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 630626009750 active site 630626009751 NTP binding site [chemical binding]; other site 630626009752 metal binding triad [ion binding]; metal-binding site 630626009753 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 630626009754 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 630626009755 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 630626009756 catalytic center binding site [active] 630626009757 ATP binding site [chemical binding]; other site 630626009758 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 630626009759 oligomerization interface [polypeptide binding]; other site 630626009760 active site 630626009761 metal binding site [ion binding]; metal-binding site 630626009762 pantoate--beta-alanine ligase; Region: panC; TIGR00018 630626009763 Pantoate-beta-alanine ligase; Region: PanC; cd00560 630626009764 active site 630626009765 ATP-binding site [chemical binding]; other site 630626009766 pantoate-binding site; other site 630626009767 HXXH motif; other site 630626009768 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 630626009769 tetramerization interface [polypeptide binding]; other site 630626009770 active site 630626009771 Bacterial SH3 domain; Region: SH3_3; pfam08239 630626009772 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 630626009773 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 630626009774 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 630626009775 active pocket/dimerization site; other site 630626009776 active site 630626009777 phosphorylation site [posttranslational modification] 630626009778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626009779 active site 630626009780 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 630626009781 active site clefts [active] 630626009782 zinc binding site [ion binding]; other site 630626009783 dimer interface [polypeptide binding]; other site 630626009784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 630626009785 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 630626009786 Walker A/P-loop; other site 630626009787 ATP binding site [chemical binding]; other site 630626009788 Q-loop/lid; other site 630626009789 ABC transporter signature motif; other site 630626009790 Walker B; other site 630626009791 D-loop; other site 630626009792 H-loop/switch region; other site 630626009793 inner membrane transport permease; Provisional; Region: PRK15066 630626009794 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626009795 multicopper oxidase; Provisional; Region: PRK10965 630626009796 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 630626009797 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 630626009798 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 630626009799 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 630626009800 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 630626009801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 630626009802 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 630626009803 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 630626009804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 630626009805 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 630626009806 hypothetical protein; Provisional; Region: PRK05248 630626009807 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 630626009808 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 630626009809 substrate binding site [chemical binding]; other site 630626009810 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 630626009811 substrate binding site [chemical binding]; other site 630626009812 ligand binding site [chemical binding]; other site 630626009813 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 630626009814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 630626009815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626009816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 630626009817 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 630626009818 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 630626009819 E3 interaction surface; other site 630626009820 lipoyl attachment site [posttranslational modification]; other site 630626009821 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 630626009822 E3 interaction surface; other site 630626009823 lipoyl attachment site [posttranslational modification]; other site 630626009824 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 630626009825 E3 interaction surface; other site 630626009826 lipoyl attachment site [posttranslational modification]; other site 630626009827 e3 binding domain; Region: E3_binding; pfam02817 630626009828 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 630626009829 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 630626009830 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 630626009831 dimer interface [polypeptide binding]; other site 630626009832 TPP-binding site [chemical binding]; other site 630626009833 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 630626009834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626009835 DNA-binding site [nucleotide binding]; DNA binding site 630626009836 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626009837 aromatic amino acid transporter; Provisional; Region: PRK10238 630626009838 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 630626009839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626009840 putative substrate translocation pore; other site 630626009841 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 630626009842 active site 630626009843 regulatory protein AmpE; Provisional; Region: PRK10987 630626009844 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 630626009845 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 630626009846 amidase catalytic site [active] 630626009847 substrate binding site [chemical binding]; other site 630626009848 Zn binding residues [ion binding]; other site 630626009849 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 630626009850 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 630626009851 dimerization interface [polypeptide binding]; other site 630626009852 active site 630626009853 putative major pilin subunit; Provisional; Region: PRK10574 630626009854 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 630626009855 Pilin (bacterial filament); Region: Pilin; pfam00114 630626009856 hypothetical protein; Provisional; Region: PRK10436 630626009857 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 630626009858 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 630626009859 Walker A motif; other site 630626009860 ATP binding site [chemical binding]; other site 630626009861 Walker B motif; other site 630626009862 type IV pilin biogenesis protein; Provisional; Region: PRK10573 630626009863 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 630626009864 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 630626009865 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 630626009866 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 630626009867 active site 630626009868 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 630626009869 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 630626009870 CoA-binding site [chemical binding]; other site 630626009871 ATP-binding [chemical binding]; other site 630626009872 hypothetical protein; Provisional; Region: PRK05287 630626009873 DNA gyrase inhibitor; Reviewed; Region: PRK00418 630626009874 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 630626009875 active site 630626009876 8-oxo-dGMP binding site [chemical binding]; other site 630626009877 nudix motif; other site 630626009878 metal binding site [ion binding]; metal-binding site 630626009879 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 630626009880 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 630626009881 SEC-C motif; Region: SEC-C; pfam02810 630626009882 SecA regulator SecM; Provisional; Region: PRK02943 630626009883 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 630626009884 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 630626009885 cell division protein FtsZ; Validated; Region: PRK09330 630626009886 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 630626009887 nucleotide binding site [chemical binding]; other site 630626009888 SulA interaction site; other site 630626009889 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 630626009890 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 630626009891 Cell division protein FtsA; Region: FtsA; pfam14450 630626009892 cell division protein FtsQ; Provisional; Region: PRK10775 630626009893 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 630626009894 Cell division protein FtsQ; Region: FtsQ; pfam03799 630626009895 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 630626009896 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 630626009897 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 630626009898 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 630626009899 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 630626009900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626009901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626009902 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 630626009903 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 630626009904 active site 630626009905 homodimer interface [polypeptide binding]; other site 630626009906 cell division protein FtsW; Provisional; Region: PRK10774 630626009907 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 630626009908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626009909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626009910 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 630626009911 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 630626009912 Mg++ binding site [ion binding]; other site 630626009913 putative catalytic motif [active] 630626009914 putative substrate binding site [chemical binding]; other site 630626009915 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 630626009916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 630626009917 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626009918 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626009919 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 630626009920 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 630626009921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626009922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626009923 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 630626009924 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 630626009925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 630626009926 cell division protein FtsL; Provisional; Region: PRK10772 630626009927 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 630626009928 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 630626009929 cell division protein MraZ; Reviewed; Region: PRK00326 630626009930 MraZ protein; Region: MraZ; pfam02381 630626009931 MraZ protein; Region: MraZ; pfam02381 630626009932 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 630626009933 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626009934 DNA binding site [nucleotide binding] 630626009935 domain linker motif; other site 630626009936 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 630626009937 dimerization interface [polypeptide binding]; other site 630626009938 ligand binding site [chemical binding]; other site 630626009939 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 630626009940 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 630626009941 putative valine binding site [chemical binding]; other site 630626009942 dimer interface [polypeptide binding]; other site 630626009943 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 630626009944 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 630626009945 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 630626009946 PYR/PP interface [polypeptide binding]; other site 630626009947 dimer interface [polypeptide binding]; other site 630626009948 TPP binding site [chemical binding]; other site 630626009949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 630626009950 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 630626009951 TPP-binding site [chemical binding]; other site 630626009952 dimer interface [polypeptide binding]; other site 630626009953 2-isopropylmalate synthase; Validated; Region: PRK00915 630626009954 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 630626009955 active site 630626009956 catalytic residues [active] 630626009957 metal binding site [ion binding]; metal-binding site 630626009958 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 630626009959 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 630626009960 tartrate dehydrogenase; Region: TTC; TIGR02089 630626009961 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 630626009962 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 630626009963 substrate binding site [chemical binding]; other site 630626009964 ligand binding site [chemical binding]; other site 630626009965 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 630626009966 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 630626009967 substrate binding site [chemical binding]; other site 630626009968 transcriptional regulator SgrR; Provisional; Region: PRK13626 630626009969 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 630626009970 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 630626009971 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 630626009972 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 630626009973 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 630626009974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626009975 dimer interface [polypeptide binding]; other site 630626009976 conserved gate region; other site 630626009977 putative PBP binding loops; other site 630626009978 ABC-ATPase subunit interface; other site 630626009979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626009980 dimer interface [polypeptide binding]; other site 630626009981 conserved gate region; other site 630626009982 putative PBP binding loops; other site 630626009983 ABC-ATPase subunit interface; other site 630626009984 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 630626009985 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 630626009986 Walker A/P-loop; other site 630626009987 ATP binding site [chemical binding]; other site 630626009988 Q-loop/lid; other site 630626009989 ABC transporter signature motif; other site 630626009990 Walker B; other site 630626009991 D-loop; other site 630626009992 H-loop/switch region; other site 630626009993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 630626009994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 630626009995 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 630626009996 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 630626009997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626009998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626009999 ribulokinase; Provisional; Region: PRK04123 630626010000 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 630626010001 N- and C-terminal domain interface [polypeptide binding]; other site 630626010002 active site 630626010003 MgATP binding site [chemical binding]; other site 630626010004 catalytic site [active] 630626010005 metal binding site [ion binding]; metal-binding site 630626010006 carbohydrate binding site [chemical binding]; other site 630626010007 homodimer interface [polypeptide binding]; other site 630626010008 L-arabinose isomerase; Provisional; Region: PRK02929 630626010009 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 630626010010 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 630626010011 trimer interface [polypeptide binding]; other site 630626010012 putative substrate binding site [chemical binding]; other site 630626010013 putative metal binding site [ion binding]; other site 630626010014 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 630626010015 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 630626010016 intersubunit interface [polypeptide binding]; other site 630626010017 active site 630626010018 Zn2+ binding site [ion binding]; other site 630626010019 DNA polymerase II; Reviewed; Region: PRK05762 630626010020 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 630626010021 active site 630626010022 catalytic site [active] 630626010023 substrate binding site [chemical binding]; other site 630626010024 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 630626010025 active site 630626010026 metal-binding site 630626010027 ATP-dependent helicase HepA; Validated; Region: PRK04914 630626010028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626010029 ATP binding site [chemical binding]; other site 630626010030 putative Mg++ binding site [ion binding]; other site 630626010031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626010032 nucleotide binding region [chemical binding]; other site 630626010033 ATP-binding site [chemical binding]; other site 630626010034 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 630626010035 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 630626010036 active site 630626010037 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 630626010038 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 630626010039 putative metal binding site [ion binding]; other site 630626010040 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 630626010041 HSP70 interaction site [polypeptide binding]; other site 630626010042 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 630626010043 OstA-like protein; Region: OstA; pfam03968 630626010044 Organic solvent tolerance protein; Region: OstA_C; pfam04453 630626010045 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 630626010046 SurA N-terminal domain; Region: SurA_N; pfam09312 630626010047 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 630626010048 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 630626010049 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 630626010050 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 630626010051 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 630626010052 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 630626010053 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 630626010054 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 630626010055 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 630626010056 active site 630626010057 metal binding site [ion binding]; metal-binding site 630626010058 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 630626010059 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 630626010060 folate binding site [chemical binding]; other site 630626010061 NADP+ binding site [chemical binding]; other site 630626010062 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 630626010063 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 630626010064 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 630626010065 TrkA-N domain; Region: TrkA_N; pfam02254 630626010066 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 630626010067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626010068 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 630626010069 putative substrate translocation pore; other site 630626010070 ferredoxin-like protein FixX; Provisional; Region: PRK15449 630626010071 putative oxidoreductase FixC; Provisional; Region: PRK10157 630626010072 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 630626010073 Electron transfer flavoprotein domain; Region: ETF; smart00893 630626010074 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 630626010075 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 630626010076 Ligand binding site [chemical binding]; other site 630626010077 Electron transfer flavoprotein domain; Region: ETF; pfam01012 630626010078 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 630626010079 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 630626010080 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 630626010081 active site 630626010082 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 630626010083 CoA-transferase family III; Region: CoA_transf_3; pfam02515 630626010084 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 630626010085 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 630626010086 acyl-activating enzyme (AAE) consensus motif; other site 630626010087 putative AMP binding site [chemical binding]; other site 630626010088 putative active site [active] 630626010089 putative CoA binding site [chemical binding]; other site 630626010090 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 630626010091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626010092 substrate binding site [chemical binding]; other site 630626010093 oxyanion hole (OAH) forming residues; other site 630626010094 trimer interface [polypeptide binding]; other site 630626010095 carnitine operon protein CaiE; Provisional; Region: PRK13627 630626010096 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 630626010097 putative trimer interface [polypeptide binding]; other site 630626010098 putative metal binding site [ion binding]; other site 630626010099 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 630626010100 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 630626010101 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 630626010102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 630626010103 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 630626010104 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 630626010105 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 630626010106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 630626010107 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 630626010108 IMP binding site; other site 630626010109 dimer interface [polypeptide binding]; other site 630626010110 interdomain contacts; other site 630626010111 partial ornithine binding site; other site 630626010112 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 630626010113 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 630626010114 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 630626010115 catalytic site [active] 630626010116 subunit interface [polypeptide binding]; other site 630626010117 dihydrodipicolinate reductase; Provisional; Region: PRK00048 630626010118 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 630626010119 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 630626010120 Transcriptional regulators [Transcription]; Region: FadR; COG2186 630626010121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626010122 DNA-binding site [nucleotide binding]; DNA binding site 630626010123 FCD domain; Region: FCD; pfam07729 630626010124 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 630626010125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626010126 putative substrate translocation pore; other site 630626010127 Dehydratase family; Region: ILVD_EDD; pfam00920 630626010128 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 630626010129 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 630626010130 inhibitor site; inhibition site 630626010131 active site 630626010132 dimer interface [polypeptide binding]; other site 630626010133 catalytic residue [active] 630626010134 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 630626010135 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 630626010136 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 630626010137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 630626010138 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 630626010139 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 630626010140 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 630626010141 HIGH motif; other site 630626010142 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 630626010143 active site 630626010144 KMSKS motif; other site 630626010145 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 630626010146 tRNA binding surface [nucleotide binding]; other site 630626010147 anticodon binding site; other site 630626010148 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 630626010149 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 630626010150 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 630626010151 active site 630626010152 Riboflavin kinase; Region: Flavokinase; smart00904 630626010153 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 630626010154 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 630626010155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010156 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 630626010157 putative dimerization interface [polypeptide binding]; other site 630626010158 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 630626010159 chaperone protein DnaJ; Provisional; Region: PRK10767 630626010160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 630626010161 HSP70 interaction site [polypeptide binding]; other site 630626010162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 630626010163 substrate binding site [polypeptide binding]; other site 630626010164 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 630626010165 Zn binding sites [ion binding]; other site 630626010166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 630626010167 dimer interface [polypeptide binding]; other site 630626010168 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 630626010169 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 630626010170 nucleotide binding site [chemical binding]; other site 630626010171 NEF interaction site [polypeptide binding]; other site 630626010172 SBD interface [polypeptide binding]; other site 630626010173 hypothetical protein; Provisional; Region: PRK10659 630626010174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 630626010175 MPT binding site; other site 630626010176 trimer interface [polypeptide binding]; other site 630626010177 transaldolase-like protein; Provisional; Region: PTZ00411 630626010178 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 630626010179 active site 630626010180 dimer interface [polypeptide binding]; other site 630626010181 catalytic residue [active] 630626010182 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 630626010183 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 630626010184 hypothetical protein; Validated; Region: PRK02101 630626010185 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 630626010186 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 630626010187 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 630626010188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626010189 catalytic residue [active] 630626010190 homoserine kinase; Provisional; Region: PRK01212 630626010191 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 630626010192 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 630626010193 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 630626010194 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 630626010195 putative catalytic residues [active] 630626010196 putative nucleotide binding site [chemical binding]; other site 630626010197 putative aspartate binding site [chemical binding]; other site 630626010198 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 630626010199 dimer interface [polypeptide binding]; other site 630626010200 putative threonine allosteric regulatory site; other site 630626010201 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 630626010202 putative threonine allosteric regulatory site; other site 630626010203 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 630626010204 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 630626010205 putative RNA methyltransferase; Provisional; Region: PRK10433 630626010206 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 630626010207 two-component response regulator; Provisional; Region: PRK11173 630626010208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626010209 active site 630626010210 phosphorylation site [posttranslational modification] 630626010211 intermolecular recognition site; other site 630626010212 dimerization interface [polypeptide binding]; other site 630626010213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626010214 DNA binding site [nucleotide binding] 630626010215 hypothetical protein; Provisional; Region: PRK10756 630626010216 CreA protein; Region: CreA; pfam05981 630626010217 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 630626010218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626010219 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 630626010220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 630626010221 catalytic core [active] 630626010222 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 630626010223 Trp operon repressor; Provisional; Region: PRK01381 630626010224 lytic murein transglycosylase; Provisional; Region: PRK11619 630626010225 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 630626010226 N-acetyl-D-glucosamine binding site [chemical binding]; other site 630626010227 catalytic residue [active] 630626010228 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 630626010229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626010230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626010231 ABC transporter; Region: ABC_tran_2; pfam12848 630626010232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 630626010233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626010234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010235 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 630626010236 putative effector binding pocket; other site 630626010237 dimerization interface [polypeptide binding]; other site 630626010238 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 630626010239 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 630626010240 putative NAD(P) binding site [chemical binding]; other site 630626010241 dimer interface [polypeptide binding]; other site 630626010242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 630626010243 non-specific DNA binding site [nucleotide binding]; other site 630626010244 salt bridge; other site 630626010245 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 630626010246 sequence-specific DNA binding site [nucleotide binding]; other site 630626010247 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 630626010248 active site 630626010249 (T/H)XGH motif; other site 630626010250 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 630626010251 DNA repair protein RadA; Region: sms; TIGR00416 630626010252 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 630626010253 Walker A motif/ATP binding site; other site 630626010254 ATP binding site [chemical binding]; other site 630626010255 Walker B motif; other site 630626010256 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 630626010257 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 630626010258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626010259 motif I; other site 630626010260 motif II; other site 630626010261 hypothetical protein; Provisional; Region: PRK11246 630626010262 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 630626010263 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 630626010264 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 630626010265 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 630626010266 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 630626010267 phosphopentomutase; Provisional; Region: PRK05362 630626010268 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 630626010269 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 630626010270 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 630626010271 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 630626010272 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 630626010273 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 630626010274 intersubunit interface [polypeptide binding]; other site 630626010275 active site 630626010276 catalytic residue [active] 630626010277 TRL-like protein family; Region: TRL; pfam13146 630626010278 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 630626010279 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 630626010280 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 630626010281 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 630626010282 putative fimbrial protein TcfA; Provisional; Region: PRK15308 630626010283 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 630626010284 active site 630626010285 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 630626010286 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 630626010287 active site 630626010288 nucleophile elbow; other site 630626010289 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 630626010290 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 630626010291 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 630626010292 G1 box; other site 630626010293 putative GEF interaction site [polypeptide binding]; other site 630626010294 GTP/Mg2+ binding site [chemical binding]; other site 630626010295 Switch I region; other site 630626010296 G2 box; other site 630626010297 G3 box; other site 630626010298 Switch II region; other site 630626010299 G4 box; other site 630626010300 G5 box; other site 630626010301 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 630626010302 dUMP phosphatase; Provisional; Region: PRK09449 630626010303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626010304 motif II; other site 630626010305 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 630626010306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626010307 Coenzyme A binding pocket [chemical binding]; other site 630626010308 DNA polymerase III subunit psi; Validated; Region: PRK06856 630626010309 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 630626010310 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 630626010311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626010312 S-adenosylmethionine binding site [chemical binding]; other site 630626010313 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 630626010314 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 630626010315 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 630626010316 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 630626010317 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 630626010318 putative deacylase active site [active] 630626010319 putative sialic acid transporter; Region: 2A0112; TIGR00891 630626010320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626010321 putative substrate translocation pore; other site 630626010322 Uncharacterized conserved protein [Function unknown]; Region: COG2966 630626010323 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 630626010324 hypothetical protein; Provisional; Region: PRK09917 630626010325 primosomal protein DnaI; Provisional; Region: PRK02854 630626010326 DNA replication protein DnaC; Validated; Region: PRK07952 630626010327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626010328 Walker A motif; other site 630626010329 ATP binding site [chemical binding]; other site 630626010330 phosphoglycerol transferase I; Provisional; Region: PRK03776 630626010331 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 630626010332 hypothetical protein; Provisional; Region: PRK11667 630626010333 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 630626010334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 630626010335 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 630626010336 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 630626010337 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 630626010338 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 630626010339 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 630626010340 NAD binding site [chemical binding]; other site 630626010341 catalytic residues [active] 630626010342 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 630626010343 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 630626010344 putative active site [active] 630626010345 putative metal binding site [ion binding]; other site 630626010346 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 630626010347 putative substrate binding pocket [chemical binding]; other site 630626010348 trimer interface [polypeptide binding]; other site 630626010349 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 630626010350 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 630626010351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626010352 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 630626010353 putative substrate translocation pore; other site 630626010354 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 630626010355 Cupin domain; Region: Cupin_2; pfam07883 630626010356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626010357 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 630626010358 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 630626010359 Flavin Reductases; Region: FlaRed; cl00801 630626010360 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626010361 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626010362 TM-ABC transporter signature motif; other site 630626010363 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626010364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626010365 TM-ABC transporter signature motif; other site 630626010366 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 630626010367 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 630626010368 Walker A/P-loop; other site 630626010369 ATP binding site [chemical binding]; other site 630626010370 Q-loop/lid; other site 630626010371 ABC transporter signature motif; other site 630626010372 Walker B; other site 630626010373 D-loop; other site 630626010374 H-loop/switch region; other site 630626010375 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 630626010376 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 630626010377 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 630626010378 ligand binding site [chemical binding]; other site 630626010379 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 630626010380 azoreductase; Reviewed; Region: PRK00170 630626010381 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626010382 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 630626010383 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 630626010384 putative active site [active] 630626010385 sensory histidine kinase DcuS; Provisional; Region: PRK11086 630626010386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626010387 putative active site [active] 630626010388 heme pocket [chemical binding]; other site 630626010389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626010390 ATP binding site [chemical binding]; other site 630626010391 Mg2+ binding site [ion binding]; other site 630626010392 G-X-G motif; other site 630626010393 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 630626010394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626010395 active site 630626010396 phosphorylation site [posttranslational modification] 630626010397 intermolecular recognition site; other site 630626010398 dimerization interface [polypeptide binding]; other site 630626010399 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 630626010400 ApbE family; Region: ApbE; pfam02424 630626010401 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 630626010402 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 630626010403 putative active site [active] 630626010404 putative FMN binding site [chemical binding]; other site 630626010405 putative substrate binding site [chemical binding]; other site 630626010406 putative catalytic residue [active] 630626010407 FMN-binding domain; Region: FMN_bind; cl01081 630626010408 L-aspartate oxidase; Provisional; Region: PRK06175 630626010409 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 630626010410 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 630626010411 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 630626010412 transmembrane helices; other site 630626010413 fumarate hydratase; Provisional; Region: PRK15389 630626010414 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 630626010415 Fumarase C-terminus; Region: Fumerase_C; pfam05683 630626010416 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 630626010417 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 630626010418 E-class dimer interface [polypeptide binding]; other site 630626010419 P-class dimer interface [polypeptide binding]; other site 630626010420 active site 630626010421 Cu2+ binding site [ion binding]; other site 630626010422 Zn2+ binding site [ion binding]; other site 630626010423 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 630626010424 putative hydrophobic ligand binding site [chemical binding]; other site 630626010425 ACT domain-containing protein [General function prediction only]; Region: COG4747 630626010426 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 630626010427 PB1 interaction surface [polypeptide binding]; other site 630626010428 PB1 interaction site [polypeptide binding]; other site 630626010429 PB1 interaction site [polypeptide binding]; other site 630626010430 PB1 interaction surface [polypeptide binding]; other site 630626010431 PB1 interaction surface [polypeptide binding]; other site 630626010432 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 630626010433 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 630626010434 active site 630626010435 homodimer interface [polypeptide binding]; other site 630626010436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626010437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010438 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 630626010439 substrate binding pocket [chemical binding]; other site 630626010440 dimerization interface [polypeptide binding]; other site 630626010441 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 630626010442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 630626010443 catalytic loop [active] 630626010444 iron binding site [ion binding]; other site 630626010445 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 630626010446 FAD binding pocket [chemical binding]; other site 630626010447 FAD binding motif [chemical binding]; other site 630626010448 phosphate binding motif [ion binding]; other site 630626010449 beta-alpha-beta structure motif; other site 630626010450 NAD binding pocket [chemical binding]; other site 630626010451 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 630626010452 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 630626010453 iron-sulfur cluster [ion binding]; other site 630626010454 [2Fe-2S] cluster binding site [ion binding]; other site 630626010455 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 630626010456 putative alpha subunit interface [polypeptide binding]; other site 630626010457 putative active site [active] 630626010458 putative substrate binding site [chemical binding]; other site 630626010459 Fe binding site [ion binding]; other site 630626010460 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 630626010461 inter-subunit interface; other site 630626010462 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 630626010463 [2Fe-2S] cluster binding site [ion binding]; other site 630626010464 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 630626010465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 630626010466 DNA binding site [nucleotide binding] 630626010467 Helix-turn-helix domain; Region: HTH_17; pfam12728 630626010468 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 630626010469 Surface antigen; Region: Bac_surface_Ag; pfam01103 630626010470 Peptidase family C69; Region: Peptidase_C69; pfam03577 630626010471 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 630626010472 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 630626010473 BON domain; Region: BON; pfam04972 630626010474 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 630626010475 DctM-like transporters; Region: DctM; pfam06808 630626010476 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 630626010477 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 630626010478 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 630626010479 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 630626010480 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 630626010481 dimer interface [polypeptide binding]; other site 630626010482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 630626010483 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 630626010484 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 630626010485 4Fe-4S binding domain; Region: Fer4; pfam00037 630626010486 hydrogenase 4 subunit B; Validated; Region: PRK06521 630626010487 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626010488 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 630626010489 NADH dehydrogenase; Region: NADHdh; cl00469 630626010490 hydrogenase 4 subunit D; Validated; Region: PRK06525 630626010491 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626010492 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 630626010493 hydrogenase 4 subunit F; Validated; Region: PRK06458 630626010494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 630626010495 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 630626010496 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 630626010497 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 630626010498 hydrogenase 4 subunit H; Validated; Region: PRK08222 630626010499 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 630626010500 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 630626010501 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 630626010502 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 630626010503 GAF domain; Region: GAF; pfam01590 630626010504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626010505 Walker A motif; other site 630626010506 ATP binding site [chemical binding]; other site 630626010507 Walker B motif; other site 630626010508 arginine finger; other site 630626010509 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 630626010510 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 630626010511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626010512 Transposase; Region: HTH_Tnp_1; pfam01527 630626010513 HTH-like domain; Region: HTH_21; pfam13276 630626010514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626010515 Integrase core domain; Region: rve; pfam00665 630626010516 Integrase core domain; Region: rve_3; pfam13683 630626010517 Transposase; Region: DEDD_Tnp_IS110; pfam01548 630626010518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 630626010519 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 630626010520 Integrase core domain; Region: rve; pfam00665 630626010521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 630626010522 Transposase; Region: HTH_Tnp_1; pfam01527 630626010523 Transposase; Region: HTH_Tnp_1; pfam01527 630626010524 HTH-like domain; Region: HTH_21; pfam13276 630626010525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626010526 Integrase core domain; Region: rve; pfam00665 630626010527 Integrase core domain; Region: rve_3; pfam13683 630626010528 DEAD-like helicases superfamily; Region: DEXDc; smart00487 630626010529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626010530 ATP binding site [chemical binding]; other site 630626010531 putative Mg++ binding site [ion binding]; other site 630626010532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626010533 nucleotide binding region [chemical binding]; other site 630626010534 ATP-binding site [chemical binding]; other site 630626010535 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 630626010536 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 630626010537 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 630626010538 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 630626010539 HsdM N-terminal domain; Region: HsdM_N; pfam12161 630626010540 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 630626010541 Methyltransferase domain; Region: Methyltransf_26; pfam13659 630626010542 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 630626010543 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 630626010544 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 630626010545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626010546 ATP binding site [chemical binding]; other site 630626010547 putative Mg++ binding site [ion binding]; other site 630626010548 integrase; Provisional; Region: PRK09692 630626010549 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 630626010550 active site 630626010551 Int/Topo IB signature motif; other site 630626010552 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 630626010553 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 630626010554 putative NAD(P) binding site [chemical binding]; other site 630626010555 putative substrate binding site [chemical binding]; other site 630626010556 catalytic Zn binding site [ion binding]; other site 630626010557 structural Zn binding site [ion binding]; other site 630626010558 dimer interface [polypeptide binding]; other site 630626010559 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 630626010560 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 630626010561 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 630626010562 NADP binding site [chemical binding]; other site 630626010563 Predicted transcriptional regulators [Transcription]; Region: COG1733 630626010564 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 630626010565 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 630626010566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 630626010567 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 630626010568 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 630626010569 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 630626010570 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 630626010571 multifunctional aminopeptidase A; Provisional; Region: PRK00913 630626010572 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 630626010573 interface (dimer of trimers) [polypeptide binding]; other site 630626010574 Substrate-binding/catalytic site; other site 630626010575 Zn-binding sites [ion binding]; other site 630626010576 DNA polymerase III subunit chi; Validated; Region: PRK05728 630626010577 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 630626010578 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 630626010579 HIGH motif; other site 630626010580 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 630626010581 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 630626010582 active site 630626010583 KMSKS motif; other site 630626010584 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 630626010585 tRNA binding surface [nucleotide binding]; other site 630626010586 anticodon binding site; other site 630626010587 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 630626010588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 630626010589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626010590 Coenzyme A binding pocket [chemical binding]; other site 630626010591 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 630626010592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626010593 ABC-ATPase subunit interface; other site 630626010594 dimer interface [polypeptide binding]; other site 630626010595 putative PBP binding regions; other site 630626010596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 630626010597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626010598 ABC-ATPase subunit interface; other site 630626010599 dimer interface [polypeptide binding]; other site 630626010600 putative PBP binding regions; other site 630626010601 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 630626010602 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 630626010603 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 630626010604 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 630626010605 metal binding site [ion binding]; metal-binding site 630626010606 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 630626010607 active site 630626010608 dinuclear metal binding site [ion binding]; other site 630626010609 dimerization interface [polypeptide binding]; other site 630626010610 RNase E inhibitor protein; Provisional; Region: PRK11191 630626010611 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 630626010612 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 630626010613 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 630626010614 Domain of unknown function (DUF386); Region: DUF386; cl01047 630626010615 putrescine transporter; Provisional; Region: potE; PRK10655 630626010616 ornithine decarboxylase; Provisional; Region: PRK13578 630626010617 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 630626010618 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 630626010619 homodimer interface [polypeptide binding]; other site 630626010620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626010621 catalytic residue [active] 630626010622 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 630626010623 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 630626010624 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 630626010625 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 630626010626 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 630626010627 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 630626010628 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 630626010629 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 630626010630 homotrimer interaction site [polypeptide binding]; other site 630626010631 putative active site [active] 630626010632 DctM-like transporters; Region: DctM; pfam06808 630626010633 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 630626010634 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 630626010635 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 630626010636 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 630626010637 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 630626010638 ATP cone domain; Region: ATP-cone; pfam03477 630626010639 Class III ribonucleotide reductase; Region: RNR_III; cd01675 630626010640 effector binding site; other site 630626010641 active site 630626010642 Zn binding site [ion binding]; other site 630626010643 glycine loop; other site 630626010644 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 630626010645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626010646 FeS/SAM binding site; other site 630626010647 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 630626010648 HTH domain; Region: HTH_11; cl17392 630626010649 Mga helix-turn-helix domain; Region: Mga; pfam05043 630626010650 PRD domain; Region: PRD; pfam00874 630626010651 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 630626010652 active site 630626010653 P-loop; other site 630626010654 phosphorylation site [posttranslational modification] 630626010655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 630626010656 active site 630626010657 phosphorylation site [posttranslational modification] 630626010658 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 630626010659 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 630626010660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626010661 catalytic residue [active] 630626010662 dihydroorotase; Provisional; Region: PRK09237 630626010663 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 630626010664 active site 630626010665 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 630626010666 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 630626010667 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 630626010668 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 630626010669 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 630626010670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626010671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010672 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 630626010673 putative dimerization interface [polypeptide binding]; other site 630626010674 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 630626010675 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 630626010676 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 630626010677 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 630626010678 Membrane transport protein; Region: Mem_trans; cl09117 630626010679 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 630626010680 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 630626010681 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 630626010682 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 630626010683 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 630626010684 Coenzyme A transferase; Region: CoA_trans; cl17247 630626010685 Cytochrome b562; Region: Cytochrom_B562; cl01546 630626010686 peptidase PmbA; Provisional; Region: PRK11040 630626010687 hypothetical protein; Provisional; Region: PRK05255 630626010688 hypothetical protein; Provisional; Region: PRK09956 630626010689 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 630626010690 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 630626010691 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 630626010692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 630626010693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 630626010694 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 630626010695 AMP binding site [chemical binding]; other site 630626010696 metal binding site [ion binding]; metal-binding site 630626010697 active site 630626010698 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626010699 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626010700 TM-ABC transporter signature motif; other site 630626010701 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626010702 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626010703 TM-ABC transporter signature motif; other site 630626010704 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 630626010705 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 630626010706 Walker A/P-loop; other site 630626010707 ATP binding site [chemical binding]; other site 630626010708 Q-loop/lid; other site 630626010709 ABC transporter signature motif; other site 630626010710 Walker B; other site 630626010711 D-loop; other site 630626010712 H-loop/switch region; other site 630626010713 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 630626010714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 630626010715 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 630626010716 putative ligand binding site [chemical binding]; other site 630626010717 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 630626010718 dimer interface [polypeptide binding]; other site 630626010719 substrate binding site [chemical binding]; other site 630626010720 metal binding sites [ion binding]; metal-binding site 630626010721 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 630626010722 putative active site pocket [active] 630626010723 dimerization interface [polypeptide binding]; other site 630626010724 putative catalytic residue [active] 630626010725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 630626010726 Family of unknown function (DUF490); Region: DUF490; pfam04357 630626010727 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 630626010728 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 630626010729 Surface antigen; Region: Bac_surface_Ag; pfam01103 630626010730 methionine sulfoxide reductase A; Provisional; Region: PRK00058 630626010731 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 630626010732 Domain of unknown function DUF21; Region: DUF21; pfam01595 630626010733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 630626010734 Transporter associated domain; Region: CorC_HlyC; smart01091 630626010735 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 630626010736 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 630626010737 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 630626010738 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 630626010739 active site 630626010740 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 630626010741 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 630626010742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626010743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626010744 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 630626010745 EamA-like transporter family; Region: EamA; pfam00892 630626010746 EamA-like transporter family; Region: EamA; pfam00892 630626010747 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 630626010748 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 630626010749 Hemerythrin-like domain; Region: Hr-like; cd12108 630626010750 Fe binding site [ion binding]; other site 630626010751 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 630626010752 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 630626010753 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 630626010754 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 630626010755 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 630626010756 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 630626010757 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 630626010758 EamA-like transporter family; Region: EamA; cl17759 630626010759 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 630626010760 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 630626010761 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 630626010762 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 630626010763 primosomal replication protein N; Provisional; Region: PRK02801 630626010764 generic binding surface I; other site 630626010765 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 630626010766 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626010767 esterase; Provisional; Region: PRK10566 630626010768 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 630626010769 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 630626010770 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 630626010771 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 630626010772 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 630626010773 FAD binding site [chemical binding]; other site 630626010774 substrate binding site [chemical binding]; other site 630626010775 catalytic residues [active] 630626010776 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 630626010777 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 630626010778 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 630626010779 exoribonuclease R; Provisional; Region: PRK11642 630626010780 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 630626010781 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 630626010782 RNB domain; Region: RNB; pfam00773 630626010783 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 630626010784 RNA binding site [nucleotide binding]; other site 630626010785 transcriptional repressor NsrR; Provisional; Region: PRK11014 630626010786 Rrf2 family protein; Region: rrf2_super; TIGR00738 630626010787 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 630626010788 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 630626010789 GDP-binding site [chemical binding]; other site 630626010790 ACT binding site; other site 630626010791 IMP binding site; other site 630626010792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 630626010793 FtsH protease regulator HflC; Provisional; Region: PRK11029 630626010794 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 630626010795 FtsH protease regulator HflK; Provisional; Region: PRK10930 630626010796 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 630626010797 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 630626010798 GTPase HflX; Provisional; Region: PRK11058 630626010799 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 630626010800 HflX GTPase family; Region: HflX; cd01878 630626010801 G1 box; other site 630626010802 GTP/Mg2+ binding site [chemical binding]; other site 630626010803 Switch I region; other site 630626010804 G2 box; other site 630626010805 G3 box; other site 630626010806 Switch II region; other site 630626010807 G4 box; other site 630626010808 G5 box; other site 630626010809 bacterial Hfq-like; Region: Hfq; cd01716 630626010810 hexamer interface [polypeptide binding]; other site 630626010811 Sm1 motif; other site 630626010812 RNA binding site [nucleotide binding]; other site 630626010813 Sm2 motif; other site 630626010814 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 630626010815 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 630626010816 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 630626010817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626010818 Mg2+ binding site [ion binding]; other site 630626010819 G-X-G motif; other site 630626010820 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 630626010821 ATP binding site [chemical binding]; other site 630626010822 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 630626010823 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 630626010824 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 630626010825 active site 630626010826 metal binding site [ion binding]; metal-binding site 630626010827 ADP-binding protein; Provisional; Region: PRK10646 630626010828 putative carbohydrate kinase; Provisional; Region: PRK10565 630626010829 Uncharacterized conserved protein [Function unknown]; Region: COG0062 630626010830 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 630626010831 putative substrate binding site [chemical binding]; other site 630626010832 putative ATP binding site [chemical binding]; other site 630626010833 epoxyqueuosine reductase; Region: TIGR00276 630626010834 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 630626010835 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 630626010836 catalytic site [active] 630626010837 putative active site [active] 630626010838 putative substrate binding site [chemical binding]; other site 630626010839 dimer interface [polypeptide binding]; other site 630626010840 GTPase RsgA; Reviewed; Region: PRK12288 630626010841 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 630626010842 RNA binding site [nucleotide binding]; other site 630626010843 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 630626010844 GTPase/Zn-binding domain interface [polypeptide binding]; other site 630626010845 GTP/Mg2+ binding site [chemical binding]; other site 630626010846 G4 box; other site 630626010847 G5 box; other site 630626010848 G1 box; other site 630626010849 Switch I region; other site 630626010850 G2 box; other site 630626010851 G3 box; other site 630626010852 Switch II region; other site 630626010853 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 630626010854 putative mechanosensitive channel protein; Provisional; Region: PRK10929 630626010855 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 630626010856 Mechanosensitive ion channel; Region: MS_channel; pfam00924 630626010857 poxB regulator PoxA; Provisional; Region: PRK09350 630626010858 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 630626010859 motif 1; other site 630626010860 dimer interface [polypeptide binding]; other site 630626010861 active site 630626010862 motif 2; other site 630626010863 motif 3; other site 630626010864 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 630626010865 L-aspartate oxidase; Provisional; Region: PRK06175 630626010866 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 630626010867 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 630626010868 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 630626010869 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 630626010870 D-subunit interface [polypeptide binding]; other site 630626010871 Iron-sulfur protein interface; other site 630626010872 proximal quinone binding site [chemical binding]; other site 630626010873 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 630626010874 Iron-sulfur protein interface; other site 630626010875 proximal quinone binding site [chemical binding]; other site 630626010876 C-subunit interface; other site 630626010877 distal quinone binding site; other site 630626010878 multidrug efflux system protein; Provisional; Region: PRK11431 630626010879 Entericidin EcnA/B family; Region: Entericidin; cl02322 630626010880 elongation factor P; Validated; Region: PRK00529 630626010881 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 630626010882 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 630626010883 RNA binding site [nucleotide binding]; other site 630626010884 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 630626010885 RNA binding site [nucleotide binding]; other site 630626010886 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 630626010887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626010888 FeS/SAM binding site; other site 630626010889 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 630626010890 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 630626010891 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 630626010892 ring oligomerisation interface [polypeptide binding]; other site 630626010893 ATP/Mg binding site [chemical binding]; other site 630626010894 stacking interactions; other site 630626010895 hinge regions; other site 630626010896 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 630626010897 oligomerisation interface [polypeptide binding]; other site 630626010898 mobile loop; other site 630626010899 roof hairpin; other site 630626010900 putative transporter; Provisional; Region: PRK11021 630626010901 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 630626010902 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 630626010903 Aspartase; Region: Aspartase; cd01357 630626010904 active sites [active] 630626010905 tetramer interface [polypeptide binding]; other site 630626010906 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 630626010907 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 630626010908 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 630626010909 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 630626010910 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 630626010911 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 630626010912 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 630626010913 DsbD alpha interface [polypeptide binding]; other site 630626010914 catalytic residues [active] 630626010915 putative transcriptional regulator; Provisional; Region: PRK11640 630626010916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626010917 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 630626010918 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 630626010919 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 630626010920 metal binding site [ion binding]; metal-binding site 630626010921 dimer interface [polypeptide binding]; other site 630626010922 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 630626010923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626010925 dimerization interface [polypeptide binding]; other site 630626010926 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 630626010927 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 630626010928 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 630626010929 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 630626010930 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 630626010931 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 630626010932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 630626010933 putative substrate translocation pore; other site 630626010934 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 630626010935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 630626010936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626010937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010938 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 630626010939 putative effector binding pocket; other site 630626010940 putative dimerization interface [polypeptide binding]; other site 630626010941 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 630626010942 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 630626010943 Walker A/P-loop; other site 630626010944 ATP binding site [chemical binding]; other site 630626010945 Q-loop/lid; other site 630626010946 ABC transporter signature motif; other site 630626010947 Walker B; other site 630626010948 D-loop; other site 630626010949 H-loop/switch region; other site 630626010950 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 630626010951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 630626010952 ABC-ATPase subunit interface; other site 630626010953 dimer interface [polypeptide binding]; other site 630626010954 putative PBP binding regions; other site 630626010955 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 630626010956 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 630626010957 putative ligand binding residues [chemical binding]; other site 630626010958 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 630626010959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626010960 N-terminal plug; other site 630626010961 ligand-binding site [chemical binding]; other site 630626010962 hypothetical protein; Provisional; Region: PRK10220 630626010963 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 630626010964 PhnA protein; Region: PhnA; pfam03831 630626010965 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626010966 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 630626010967 molybdopterin cofactor binding site; other site 630626010968 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 630626010969 molybdopterin cofactor binding site; other site 630626010970 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 630626010971 Sel1-like repeats; Region: SEL1; smart00671 630626010972 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 630626010973 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 630626010974 acetyl-CoA synthetase; Provisional; Region: PRK00174 630626010975 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 630626010976 active site 630626010977 CoA binding site [chemical binding]; other site 630626010978 acyl-activating enzyme (AAE) consensus motif; other site 630626010979 AMP binding site [chemical binding]; other site 630626010980 acetate binding site [chemical binding]; other site 630626010981 Predicted membrane protein [Function unknown]; Region: COG3162 630626010982 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 630626010983 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 630626010984 Na binding site [ion binding]; other site 630626010985 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 630626010986 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 630626010987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626010988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626010989 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 630626010990 putative dimerization interface [polypeptide binding]; other site 630626010991 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 630626010992 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 630626010993 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 630626010994 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 630626010995 putative C-terminal domain interface [polypeptide binding]; other site 630626010996 putative GSH binding site (G-site) [chemical binding]; other site 630626010997 putative dimer interface [polypeptide binding]; other site 630626010998 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 630626010999 N-terminal domain interface [polypeptide binding]; other site 630626011000 dimer interface [polypeptide binding]; other site 630626011001 substrate binding pocket (H-site) [chemical binding]; other site 630626011002 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 630626011003 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 630626011004 DNA binding residues [nucleotide binding] 630626011005 dimer interface [polypeptide binding]; other site 630626011006 [2Fe-2S] cluster binding site [ion binding]; other site 630626011007 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 630626011008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 630626011009 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 630626011010 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626011011 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 630626011012 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 630626011013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 630626011014 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 630626011015 HlyD family secretion protein; Region: HlyD_3; pfam13437 630626011016 Homeodomain-like domain; Region: HTH_32; pfam13565 630626011017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 630626011018 Integrase core domain; Region: rve; pfam00665 630626011019 Integrase core domain; Region: rve_3; pfam13683 630626011020 Transposase; Region: HTH_Tnp_1; cl17663 630626011021 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 630626011022 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 630626011023 putative active site [active] 630626011024 putative NTP binding site [chemical binding]; other site 630626011025 putative nucleic acid binding site [nucleotide binding]; other site 630626011026 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 630626011027 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 630626011028 Type II intron maturase; Region: Intron_maturas2; pfam01348 630626011029 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 630626011030 active site 630626011031 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 630626011032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 630626011033 dimer interface [polypeptide binding]; other site 630626011034 ssDNA binding site [nucleotide binding]; other site 630626011035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 630626011036 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 630626011037 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 630626011038 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 630626011039 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 630626011040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626011042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 630626011043 dimerization interface [polypeptide binding]; other site 630626011044 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 630626011045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 630626011046 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 630626011047 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 630626011048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 630626011049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626011050 homodimer interface [polypeptide binding]; other site 630626011051 catalytic residue [active] 630626011052 alanine racemase; Reviewed; Region: alr; PRK00053 630626011053 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 630626011054 active site 630626011055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 630626011056 substrate binding site [chemical binding]; other site 630626011057 catalytic residues [active] 630626011058 dimer interface [polypeptide binding]; other site 630626011059 replicative DNA helicase; Provisional; Region: PRK08006 630626011060 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 630626011061 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 630626011062 Walker A motif; other site 630626011063 ATP binding site [chemical binding]; other site 630626011064 Walker B motif; other site 630626011065 DNA binding loops [nucleotide binding] 630626011066 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 630626011067 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 630626011068 NADP binding site [chemical binding]; other site 630626011069 dimer interface [polypeptide binding]; other site 630626011070 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 630626011071 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 630626011072 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 630626011073 FMN binding site [chemical binding]; other site 630626011074 active site 630626011075 catalytic residues [active] 630626011076 substrate binding site [chemical binding]; other site 630626011077 Cupin domain; Region: Cupin_2; cl17218 630626011078 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 630626011079 metal binding site 2 [ion binding]; metal-binding site 630626011080 putative DNA binding helix; other site 630626011081 metal binding site 1 [ion binding]; metal-binding site 630626011082 dimer interface [polypeptide binding]; other site 630626011083 structural Zn2+ binding site [ion binding]; other site 630626011084 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 630626011085 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 630626011086 LexA repressor; Validated; Region: PRK00215 630626011087 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 630626011088 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 630626011089 Catalytic site [active] 630626011090 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 630626011091 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 630626011092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 630626011093 putative acyl-acceptor binding pocket; other site 630626011094 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 630626011095 UbiA prenyltransferase family; Region: UbiA; pfam01040 630626011096 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 630626011097 maltose regulon periplasmic protein; Provisional; Region: PRK10564 630626011098 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 630626011099 trimer interface; other site 630626011100 sugar binding site [chemical binding]; other site 630626011101 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 630626011102 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 630626011103 Walker A/P-loop; other site 630626011104 ATP binding site [chemical binding]; other site 630626011105 Q-loop/lid; other site 630626011106 ABC transporter signature motif; other site 630626011107 Walker B; other site 630626011108 D-loop; other site 630626011109 H-loop/switch region; other site 630626011110 TOBE domain; Region: TOBE_2; pfam08402 630626011111 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 630626011112 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 630626011113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626011114 dimer interface [polypeptide binding]; other site 630626011115 conserved gate region; other site 630626011116 putative PBP binding loops; other site 630626011117 ABC-ATPase subunit interface; other site 630626011118 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 630626011119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626011120 dimer interface [polypeptide binding]; other site 630626011121 conserved gate region; other site 630626011122 putative PBP binding loops; other site 630626011123 ABC-ATPase subunit interface; other site 630626011124 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 630626011125 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 630626011126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 630626011127 active site 630626011128 dimer interface [polypeptide binding]; other site 630626011129 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 630626011130 dimer interface [polypeptide binding]; other site 630626011131 active site 630626011132 aspartate kinase III; Validated; Region: PRK09084 630626011133 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 630626011134 nucleotide binding site [chemical binding]; other site 630626011135 substrate binding site [chemical binding]; other site 630626011136 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 630626011137 lysine allosteric regulatory site; other site 630626011138 dimer interface [polypeptide binding]; other site 630626011139 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 630626011140 dimer interface [polypeptide binding]; other site 630626011141 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 630626011142 Sodium Bile acid symporter family; Region: SBF; pfam01758 630626011143 YjbD family (DUF3811); Region: DUF3811; cl08125 630626011144 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 630626011145 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 630626011146 RNA binding surface [nucleotide binding]; other site 630626011147 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 630626011148 probable active site [active] 630626011149 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 630626011150 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 630626011151 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 630626011152 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 630626011153 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 630626011154 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 630626011155 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 630626011156 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 630626011157 substrate binding pocket [chemical binding]; other site 630626011158 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 630626011159 B12 binding site [chemical binding]; other site 630626011160 cobalt ligand [ion binding]; other site 630626011161 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 630626011162 transcriptional repressor IclR; Provisional; Region: PRK11569 630626011163 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 630626011164 Bacterial transcriptional regulator; Region: IclR; pfam01614 630626011165 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 630626011166 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 630626011167 isocitrate lyase; Provisional; Region: PRK15063 630626011168 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 630626011169 tetramer interface [polypeptide binding]; other site 630626011170 active site 630626011171 Mg2+/Mn2+ binding site [ion binding]; other site 630626011172 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 630626011173 malate synthase A; Region: malate_syn_A; TIGR01344 630626011174 active site 630626011175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626011176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011177 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 630626011178 substrate binding pocket [chemical binding]; other site 630626011179 dimerization interface [polypeptide binding]; other site 630626011180 Amidohydrolase; Region: Amidohydro_2; pfam04909 630626011181 homoserine O-succinyltransferase; Provisional; Region: PRK05368 630626011182 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 630626011183 proposed active site lysine [active] 630626011184 conserved cys residue [active] 630626011185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 630626011186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626011187 Coenzyme A binding pocket [chemical binding]; other site 630626011188 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 630626011189 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 630626011190 purine monophosphate binding site [chemical binding]; other site 630626011191 dimer interface [polypeptide binding]; other site 630626011192 putative catalytic residues [active] 630626011193 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 630626011194 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 630626011195 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 630626011196 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 630626011197 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 630626011198 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 630626011199 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 630626011200 IHF dimer interface [polypeptide binding]; other site 630626011201 IHF - DNA interface [nucleotide binding]; other site 630626011202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 630626011203 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 630626011204 Active_site [active] 630626011205 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 630626011206 substrate binding site [chemical binding]; other site 630626011207 active site 630626011208 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 630626011209 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 630626011210 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 630626011211 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 630626011212 putative NADH binding site [chemical binding]; other site 630626011213 putative active site [active] 630626011214 nudix motif; other site 630626011215 putative metal binding site [ion binding]; other site 630626011216 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 630626011217 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 630626011218 ThiC-associated domain; Region: ThiC-associated; pfam13667 630626011219 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 630626011220 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 630626011221 thiamine phosphate binding site [chemical binding]; other site 630626011222 active site 630626011223 pyrophosphate binding site [ion binding]; other site 630626011224 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 630626011225 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 630626011226 ATP binding site [chemical binding]; other site 630626011227 substrate interface [chemical binding]; other site 630626011228 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 630626011229 thiS-thiF/thiG interaction site; other site 630626011230 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 630626011231 ThiS interaction site; other site 630626011232 putative active site [active] 630626011233 tetramer interface [polypeptide binding]; other site 630626011234 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 630626011235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626011236 FeS/SAM binding site; other site 630626011237 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 630626011238 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 630626011239 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 630626011240 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 630626011241 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 630626011242 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 630626011243 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 630626011244 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 630626011245 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 630626011246 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 630626011247 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 630626011248 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 630626011249 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 630626011250 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 630626011251 DNA binding site [nucleotide binding] 630626011252 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 630626011253 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 630626011254 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 630626011255 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 630626011256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 630626011257 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 630626011258 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 630626011259 RPB3 interaction site [polypeptide binding]; other site 630626011260 RPB1 interaction site [polypeptide binding]; other site 630626011261 RPB11 interaction site [polypeptide binding]; other site 630626011262 RPB10 interaction site [polypeptide binding]; other site 630626011263 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 630626011264 core dimer interface [polypeptide binding]; other site 630626011265 peripheral dimer interface [polypeptide binding]; other site 630626011266 L10 interface [polypeptide binding]; other site 630626011267 L11 interface [polypeptide binding]; other site 630626011268 putative EF-Tu interaction site [polypeptide binding]; other site 630626011269 putative EF-G interaction site [polypeptide binding]; other site 630626011270 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 630626011271 23S rRNA interface [nucleotide binding]; other site 630626011272 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 630626011273 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 630626011274 mRNA/rRNA interface [nucleotide binding]; other site 630626011275 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 630626011276 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 630626011277 23S rRNA interface [nucleotide binding]; other site 630626011278 L7/L12 interface [polypeptide binding]; other site 630626011279 putative thiostrepton binding site; other site 630626011280 L25 interface [polypeptide binding]; other site 630626011281 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 630626011282 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 630626011283 putative homodimer interface [polypeptide binding]; other site 630626011284 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 630626011285 heterodimer interface [polypeptide binding]; other site 630626011286 homodimer interface [polypeptide binding]; other site 630626011287 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 630626011288 elongation factor Tu; Reviewed; Region: PRK00049 630626011289 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 630626011290 G1 box; other site 630626011291 GEF interaction site [polypeptide binding]; other site 630626011292 GTP/Mg2+ binding site [chemical binding]; other site 630626011293 Switch I region; other site 630626011294 G2 box; other site 630626011295 G3 box; other site 630626011296 Switch II region; other site 630626011297 G4 box; other site 630626011298 G5 box; other site 630626011299 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 630626011300 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 630626011301 Antibiotic Binding Site [chemical binding]; other site 630626011302 pantothenate kinase; Provisional; Region: PRK05439 630626011303 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 630626011304 ATP-binding site [chemical binding]; other site 630626011305 CoA-binding site [chemical binding]; other site 630626011306 Mg2+-binding site [ion binding]; other site 630626011307 Biotin operon repressor [Transcription]; Region: BirA; COG1654 630626011308 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 630626011309 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 630626011310 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 630626011311 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 630626011312 FAD binding domain; Region: FAD_binding_4; pfam01565 630626011313 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 630626011314 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 630626011315 potassium transporter; Provisional; Region: PRK10750 630626011316 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 630626011317 hypothetical protein; Provisional; Region: PRK11568 630626011318 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 630626011319 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 630626011320 proline dipeptidase; Provisional; Region: PRK13607 630626011321 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 630626011322 active site 630626011323 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 630626011324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 630626011325 substrate binding site [chemical binding]; other site 630626011326 oxyanion hole (OAH) forming residues; other site 630626011327 trimer interface [polypeptide binding]; other site 630626011328 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 630626011329 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626011330 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 630626011331 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 630626011332 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 630626011333 dimer interface [polypeptide binding]; other site 630626011334 active site 630626011335 FMN reductase; Validated; Region: fre; PRK08051 630626011336 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 630626011337 FAD binding pocket [chemical binding]; other site 630626011338 FAD binding motif [chemical binding]; other site 630626011339 phosphate binding motif [ion binding]; other site 630626011340 beta-alpha-beta structure motif; other site 630626011341 NAD binding pocket [chemical binding]; other site 630626011342 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 630626011343 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 630626011344 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 630626011345 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 630626011346 homodimer interface [polypeptide binding]; other site 630626011347 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 630626011348 active site 630626011349 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 630626011350 sec-independent translocase; Provisional; Region: PRK01770 630626011351 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 630626011352 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 630626011353 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 630626011354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 630626011355 SCP-2 sterol transfer family; Region: SCP2; pfam02036 630626011356 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 630626011357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626011358 S-adenosylmethionine binding site [chemical binding]; other site 630626011359 DNA recombination protein RmuC; Provisional; Region: PRK10361 630626011360 RmuC family; Region: RmuC; pfam02646 630626011361 uridine phosphorylase; Provisional; Region: PRK11178 630626011362 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 630626011363 Dienelactone hydrolase family; Region: DLH; pfam01738 630626011364 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 630626011365 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 630626011366 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 630626011367 THF binding site; other site 630626011368 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 630626011369 substrate binding site [chemical binding]; other site 630626011370 THF binding site; other site 630626011371 zinc-binding site [ion binding]; other site 630626011372 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 630626011373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011374 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 630626011375 putative dimerization interface [polypeptide binding]; other site 630626011376 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 630626011377 putative hydrolase; Provisional; Region: PRK10976 630626011378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626011379 active site 630626011380 motif I; other site 630626011381 motif II; other site 630626011382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 630626011383 lysophospholipase L2; Provisional; Region: PRK10749 630626011384 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 630626011385 threonine efflux system; Provisional; Region: PRK10229 630626011386 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 630626011387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626011388 ATP binding site [chemical binding]; other site 630626011389 putative Mg++ binding site [ion binding]; other site 630626011390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626011391 nucleotide binding region [chemical binding]; other site 630626011392 ATP-binding site [chemical binding]; other site 630626011393 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 630626011394 Helicase and RNase D C-terminal; Region: HRDC; smart00341 630626011395 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 630626011396 dimerization interface [polypeptide binding]; other site 630626011397 substrate binding site [chemical binding]; other site 630626011398 active site 630626011399 calcium binding site [ion binding]; other site 630626011400 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 630626011401 CoenzymeA binding site [chemical binding]; other site 630626011402 subunit interaction site [polypeptide binding]; other site 630626011403 PHB binding site; other site 630626011404 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 630626011405 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 630626011406 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 630626011407 Cl binding site [ion binding]; other site 630626011408 oligomer interface [polypeptide binding]; other site 630626011409 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 630626011410 Part of AAA domain; Region: AAA_19; pfam13245 630626011411 Family description; Region: UvrD_C_2; pfam13538 630626011412 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 630626011413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626011414 motif II; other site 630626011415 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 630626011416 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 630626011417 active site 630626011418 DNA binding site [nucleotide binding] 630626011419 Int/Topo IB signature motif; other site 630626011420 hypothetical protein; Provisional; Region: PRK10963 630626011421 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 630626011422 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 630626011423 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 630626011424 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 630626011425 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 630626011426 putative iron binding site [ion binding]; other site 630626011427 adenylate cyclase; Provisional; Region: cyaA; PRK09450 630626011428 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 630626011429 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 630626011430 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 630626011431 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 630626011432 domain interfaces; other site 630626011433 active site 630626011434 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 630626011435 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 630626011436 active site 630626011437 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 630626011438 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 630626011439 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 630626011440 HemY protein N-terminus; Region: HemY_N; pfam07219 630626011441 Tetratricopeptide repeat; Region: TPR_2; pfam07719 630626011442 putative transport protein YifK; Provisional; Region: PRK10746 630626011443 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 630626011444 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 630626011445 putative common antigen polymerase; Provisional; Region: PRK02975 630626011446 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 630626011447 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 630626011448 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 630626011449 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 630626011450 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 630626011451 inhibitor-cofactor binding pocket; inhibition site 630626011452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626011453 catalytic residue [active] 630626011454 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 630626011455 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 630626011456 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 630626011457 substrate binding site; other site 630626011458 tetramer interface; other site 630626011459 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 630626011460 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 630626011461 NAD binding site [chemical binding]; other site 630626011462 substrate binding site [chemical binding]; other site 630626011463 homodimer interface [polypeptide binding]; other site 630626011464 active site 630626011465 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 630626011466 TrkA-N domain; Region: TrkA_N; pfam02254 630626011467 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 630626011468 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 630626011469 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 630626011470 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 630626011471 active site 630626011472 homodimer interface [polypeptide binding]; other site 630626011473 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 630626011474 Chain length determinant protein; Region: Wzz; pfam02706 630626011475 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 630626011476 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 630626011477 Mg++ binding site [ion binding]; other site 630626011478 putative catalytic motif [active] 630626011479 substrate binding site [chemical binding]; other site 630626011480 transcription termination factor Rho; Provisional; Region: rho; PRK09376 630626011481 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 630626011482 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 630626011483 RNA binding site [nucleotide binding]; other site 630626011484 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 630626011485 multimer interface [polypeptide binding]; other site 630626011486 Walker A motif; other site 630626011487 ATP binding site [chemical binding]; other site 630626011488 Walker B motif; other site 630626011489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 630626011490 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 630626011491 catalytic residues [active] 630626011492 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 630626011493 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 630626011494 ATP binding site [chemical binding]; other site 630626011495 Mg++ binding site [ion binding]; other site 630626011496 motif III; other site 630626011497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626011498 nucleotide binding region [chemical binding]; other site 630626011499 ATP-binding site [chemical binding]; other site 630626011500 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 630626011501 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 630626011502 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 630626011503 Part of AAA domain; Region: AAA_19; pfam13245 630626011504 Family description; Region: UvrD_C_2; pfam13538 630626011505 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 630626011506 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 630626011507 ketol-acid reductoisomerase; Validated; Region: PRK05225 630626011508 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 630626011509 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 630626011510 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 630626011511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011512 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 630626011513 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 630626011514 putative dimerization interface [polypeptide binding]; other site 630626011515 threonine dehydratase; Reviewed; Region: PRK09224 630626011516 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 630626011517 tetramer interface [polypeptide binding]; other site 630626011518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626011519 catalytic residue [active] 630626011520 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 630626011521 putative Ile/Val binding site [chemical binding]; other site 630626011522 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 630626011523 putative Ile/Val binding site [chemical binding]; other site 630626011524 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 630626011525 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 630626011526 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 630626011527 homodimer interface [polypeptide binding]; other site 630626011528 substrate-cofactor binding pocket; other site 630626011529 catalytic residue [active] 630626011530 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 630626011531 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 630626011532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 630626011533 PYR/PP interface [polypeptide binding]; other site 630626011534 dimer interface [polypeptide binding]; other site 630626011535 TPP binding site [chemical binding]; other site 630626011536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 630626011537 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 630626011538 TPP-binding site [chemical binding]; other site 630626011539 dimer interface [polypeptide binding]; other site 630626011540 putative ATP-dependent protease; Provisional; Region: PRK09862 630626011541 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 630626011542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626011543 Walker A motif; other site 630626011544 ATP binding site [chemical binding]; other site 630626011545 Walker B motif; other site 630626011546 arginine finger; other site 630626011547 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 630626011548 hypothetical protein; Provisional; Region: PRK11027 630626011549 transcriptional regulator HdfR; Provisional; Region: PRK03601 630626011550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 630626011552 dimerization interface [polypeptide binding]; other site 630626011553 glutamate racemase; Provisional; Region: PRK00865 630626011554 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 630626011555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 630626011556 N-terminal plug; other site 630626011557 ligand-binding site [chemical binding]; other site 630626011558 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 630626011559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626011560 S-adenosylmethionine binding site [chemical binding]; other site 630626011561 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 630626011562 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 630626011563 Sulfatase; Region: Sulfatase; pfam00884 630626011564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 630626011565 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 630626011566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626011567 FeS/SAM binding site; other site 630626011568 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 630626011569 MoxR-like ATPases [General function prediction only]; Region: COG0714 630626011570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626011571 Walker A motif; other site 630626011572 ATP binding site [chemical binding]; other site 630626011573 Walker B motif; other site 630626011574 arginine finger; other site 630626011575 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 630626011576 Protein of unknown function DUF58; Region: DUF58; pfam01882 630626011577 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 630626011578 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 630626011579 metal ion-dependent adhesion site (MIDAS); other site 630626011580 von Willebrand factor type A domain; Region: VWA_2; pfam13519 630626011581 metal ion-dependent adhesion site (MIDAS); other site 630626011582 Tetratricopeptide repeat; Region: TPR_16; pfam13432 630626011583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 630626011584 TPR motif; other site 630626011585 binding surface 630626011586 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 630626011587 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 630626011588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 630626011589 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 630626011590 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 630626011591 hypothetical protein; Provisional; Region: PRK11056 630626011592 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 630626011593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626011594 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 630626011595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 630626011596 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 630626011597 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 630626011598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626011599 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 630626011600 dimerization interface [polypeptide binding]; other site 630626011601 argininosuccinate lyase; Provisional; Region: PRK04833 630626011602 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 630626011603 active sites [active] 630626011604 tetramer interface [polypeptide binding]; other site 630626011605 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 630626011606 nucleotide binding site [chemical binding]; other site 630626011607 N-acetyl-L-glutamate binding site [chemical binding]; other site 630626011608 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 630626011609 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 630626011610 acetylornithine deacetylase; Provisional; Region: PRK05111 630626011611 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 630626011612 metal binding site [ion binding]; metal-binding site 630626011613 putative dimer interface [polypeptide binding]; other site 630626011614 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 630626011615 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 630626011616 hypothetical protein; Provisional; Region: PRK10649 630626011617 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 630626011618 Sulfatase; Region: Sulfatase; pfam00884 630626011619 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 630626011620 FAD binding site [chemical binding]; other site 630626011621 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 630626011622 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 630626011623 putative catalytic residues [active] 630626011624 putative nucleotide binding site [chemical binding]; other site 630626011625 putative aspartate binding site [chemical binding]; other site 630626011626 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 630626011627 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 630626011628 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 630626011629 cystathionine gamma-synthase; Provisional; Region: PRK08045 630626011630 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 630626011631 homodimer interface [polypeptide binding]; other site 630626011632 substrate-cofactor binding pocket; other site 630626011633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626011634 catalytic residue [active] 630626011635 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 630626011636 dimerization interface [polypeptide binding]; other site 630626011637 DNA binding site [nucleotide binding] 630626011638 corepressor binding sites; other site 630626011639 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 630626011640 primosome assembly protein PriA; Validated; Region: PRK05580 630626011641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626011642 ATP binding site [chemical binding]; other site 630626011643 putative Mg++ binding site [ion binding]; other site 630626011644 helicase superfamily c-terminal domain; Region: HELICc; smart00490 630626011645 ATP-binding site [chemical binding]; other site 630626011646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626011647 DNA binding site [nucleotide binding] 630626011648 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 630626011649 domain linker motif; other site 630626011650 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 630626011651 dimerization interface [polypeptide binding]; other site 630626011652 ligand binding site [chemical binding]; other site 630626011653 essential cell division protein FtsN; Provisional; Region: PRK10927 630626011654 cell division protein FtsN; Provisional; Region: PRK12757 630626011655 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 630626011656 active site 630626011657 HslU subunit interaction site [polypeptide binding]; other site 630626011658 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 630626011659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626011660 Walker A motif; other site 630626011661 ATP binding site [chemical binding]; other site 630626011662 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 630626011663 Walker B motif; other site 630626011664 arginine finger; other site 630626011665 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 630626011666 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 630626011667 UbiA prenyltransferase family; Region: UbiA; pfam01040 630626011668 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 630626011669 septal ring assembly protein ZapB; Provisional; Region: PRK15422 630626011670 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 630626011671 amphipathic channel; other site 630626011672 Asn-Pro-Ala signature motifs; other site 630626011673 glycerol kinase; Provisional; Region: glpK; PRK00047 630626011674 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 630626011675 N- and C-terminal domain interface [polypeptide binding]; other site 630626011676 active site 630626011677 MgATP binding site [chemical binding]; other site 630626011678 catalytic site [active] 630626011679 metal binding site [ion binding]; metal-binding site 630626011680 glycerol binding site [chemical binding]; other site 630626011681 homotetramer interface [polypeptide binding]; other site 630626011682 homodimer interface [polypeptide binding]; other site 630626011683 FBP binding site [chemical binding]; other site 630626011684 protein IIAGlc interface [polypeptide binding]; other site 630626011685 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 630626011686 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 630626011687 putative active site [active] 630626011688 ferredoxin-NADP reductase; Provisional; Region: PRK10926 630626011689 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 630626011690 FAD binding pocket [chemical binding]; other site 630626011691 FAD binding motif [chemical binding]; other site 630626011692 phosphate binding motif [ion binding]; other site 630626011693 beta-alpha-beta structure motif; other site 630626011694 NAD binding pocket [chemical binding]; other site 630626011695 Predicted membrane protein [Function unknown]; Region: COG3152 630626011696 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 630626011697 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 630626011698 triosephosphate isomerase; Provisional; Region: PRK14567 630626011699 substrate binding site [chemical binding]; other site 630626011700 dimer interface [polypeptide binding]; other site 630626011701 catalytic triad [active] 630626011702 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 630626011703 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 630626011704 transmembrane helices; other site 630626011705 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 630626011706 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 630626011707 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626011708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 630626011709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626011710 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 630626011711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626011712 substrate binding pocket [chemical binding]; other site 630626011713 membrane-bound complex binding site; other site 630626011714 hinge residues; other site 630626011715 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 630626011716 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 630626011717 active site 630626011718 ADP/pyrophosphate binding site [chemical binding]; other site 630626011719 dimerization interface [polypeptide binding]; other site 630626011720 allosteric effector site; other site 630626011721 fructose-1,6-bisphosphate binding site; other site 630626011722 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 630626011723 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 630626011724 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 630626011725 dimer interface [polypeptide binding]; other site 630626011726 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 630626011727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626011728 active site 630626011729 intermolecular recognition site; other site 630626011730 dimerization interface [polypeptide binding]; other site 630626011731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 630626011732 DNA binding site [nucleotide binding] 630626011733 two-component sensor protein; Provisional; Region: cpxA; PRK09470 630626011734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 630626011735 dimerization interface [polypeptide binding]; other site 630626011736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626011737 dimer interface [polypeptide binding]; other site 630626011738 phosphorylation site [posttranslational modification] 630626011739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626011740 ATP binding site [chemical binding]; other site 630626011741 Mg2+ binding site [ion binding]; other site 630626011742 G-X-G motif; other site 630626011743 putative rRNA methylase; Provisional; Region: PRK10358 630626011744 serine acetyltransferase; Provisional; Region: cysE; PRK11132 630626011745 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 630626011746 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 630626011747 trimer interface [polypeptide binding]; other site 630626011748 active site 630626011749 substrate binding site [chemical binding]; other site 630626011750 CoA binding site [chemical binding]; other site 630626011751 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 630626011752 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 630626011753 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 630626011754 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 630626011755 SecA binding site; other site 630626011756 Preprotein binding site; other site 630626011757 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 630626011758 GSH binding site [chemical binding]; other site 630626011759 catalytic residues [active] 630626011760 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 630626011761 active site residue [active] 630626011762 phosphoglyceromutase; Provisional; Region: PRK05434 630626011763 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 630626011764 AmiB activator; Provisional; Region: PRK11637 630626011765 Peptidase family M23; Region: Peptidase_M23; pfam01551 630626011766 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 630626011767 NodB motif; other site 630626011768 putative active site [active] 630626011769 putative catalytic site [active] 630626011770 Zn binding site [ion binding]; other site 630626011771 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 630626011772 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 630626011773 NAD(P) binding site [chemical binding]; other site 630626011774 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 630626011775 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 630626011776 substrate-cofactor binding pocket; other site 630626011777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 630626011778 catalytic residue [active] 630626011779 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 630626011780 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 630626011781 NADP binding site [chemical binding]; other site 630626011782 homopentamer interface [polypeptide binding]; other site 630626011783 substrate binding site [chemical binding]; other site 630626011784 active site 630626011785 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 630626011786 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 630626011787 putative active site [active] 630626011788 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 630626011789 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 630626011790 putative active site [active] 630626011791 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 630626011792 O-Antigen ligase; Region: Wzy_C; pfam04932 630626011793 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 630626011794 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 630626011795 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 630626011796 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 630626011797 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 630626011798 Ligand binding site; other site 630626011799 metal-binding site 630626011800 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 630626011801 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 630626011802 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 630626011803 Ligand binding site; other site 630626011804 metal-binding site 630626011805 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 630626011806 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 630626011807 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 630626011808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 630626011809 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 630626011810 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 630626011811 putative active site [active] 630626011812 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 630626011813 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 630626011814 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 630626011815 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 630626011816 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 630626011817 active site 630626011818 (T/H)XGH motif; other site 630626011819 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 630626011820 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 630626011821 DNA binding site [nucleotide binding] 630626011822 catalytic residue [active] 630626011823 H2TH interface [polypeptide binding]; other site 630626011824 putative catalytic residues [active] 630626011825 turnover-facilitating residue; other site 630626011826 intercalation triad [nucleotide binding]; other site 630626011827 8OG recognition residue [nucleotide binding]; other site 630626011828 putative reading head residues; other site 630626011829 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 630626011830 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 630626011831 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 630626011832 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 630626011833 hypothetical protein; Reviewed; Region: PRK00024 630626011834 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 630626011835 MPN+ (JAMM) motif; other site 630626011836 Zinc-binding site [ion binding]; other site 630626011837 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 630626011838 Flavoprotein; Region: Flavoprotein; pfam02441 630626011839 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 630626011840 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 630626011841 trimer interface [polypeptide binding]; other site 630626011842 active site 630626011843 division inhibitor protein; Provisional; Region: slmA; PRK09480 630626011844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 630626011845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 630626011846 active site 630626011847 ribonuclease PH; Reviewed; Region: rph; PRK00173 630626011848 Ribonuclease PH; Region: RNase_PH_bact; cd11362 630626011849 hexamer interface [polypeptide binding]; other site 630626011850 active site 630626011851 hypothetical protein; Provisional; Region: PRK11820 630626011852 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 630626011853 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 630626011854 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 630626011855 autotransport protein MisL; Provisional; Region: PRK15313 630626011856 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 630626011857 Predicted membrane protein [Function unknown]; Region: COG2860 630626011858 UPF0126 domain; Region: UPF0126; pfam03458 630626011859 UPF0126 domain; Region: UPF0126; pfam03458 630626011860 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 630626011861 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 630626011862 nucleotide binding pocket [chemical binding]; other site 630626011863 K-X-D-G motif; other site 630626011864 catalytic site [active] 630626011865 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 630626011866 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 630626011867 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 630626011868 catalytic site [active] 630626011869 G-X2-G-X-G-K; other site 630626011870 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 630626011871 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 630626011872 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 630626011873 Zn2+ binding site [ion binding]; other site 630626011874 Mg2+ binding site [ion binding]; other site 630626011875 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 630626011876 synthetase active site [active] 630626011877 NTP binding site [chemical binding]; other site 630626011878 metal binding site [ion binding]; metal-binding site 630626011879 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 630626011880 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 630626011881 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 630626011882 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 630626011883 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 630626011884 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 630626011885 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 630626011886 ssDNA binding site; other site 630626011887 generic binding surface II; other site 630626011888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 630626011889 ATP binding site [chemical binding]; other site 630626011890 putative Mg++ binding site [ion binding]; other site 630626011891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 630626011892 nucleotide binding region [chemical binding]; other site 630626011893 ATP-binding site [chemical binding]; other site 630626011894 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 630626011895 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 630626011896 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 630626011897 AsmA family; Region: AsmA; pfam05170 630626011898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 630626011899 Coenzyme A binding pocket [chemical binding]; other site 630626011900 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 630626011901 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 630626011902 putative active site [active] 630626011903 dimerization interface [polypeptide binding]; other site 630626011904 putative tRNAtyr binding site [nucleotide binding]; other site 630626011905 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 630626011906 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 630626011907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626011908 motif II; other site 630626011909 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 630626011910 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 630626011911 G1 box; other site 630626011912 putative GEF interaction site [polypeptide binding]; other site 630626011913 GTP/Mg2+ binding site [chemical binding]; other site 630626011914 Switch I region; other site 630626011915 G2 box; other site 630626011916 G3 box; other site 630626011917 Switch II region; other site 630626011918 G4 box; other site 630626011919 G5 box; other site 630626011920 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 630626011921 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 630626011922 glutamine synthetase; Provisional; Region: glnA; PRK09469 630626011923 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 630626011924 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 630626011925 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 630626011926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 630626011927 putative active site [active] 630626011928 heme pocket [chemical binding]; other site 630626011929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 630626011930 dimer interface [polypeptide binding]; other site 630626011931 phosphorylation site [posttranslational modification] 630626011932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 630626011933 ATP binding site [chemical binding]; other site 630626011934 Mg2+ binding site [ion binding]; other site 630626011935 G-X-G motif; other site 630626011936 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 630626011937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 630626011938 active site 630626011939 phosphorylation site [posttranslational modification] 630626011940 intermolecular recognition site; other site 630626011941 dimerization interface [polypeptide binding]; other site 630626011942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626011943 Walker A motif; other site 630626011944 ATP binding site [chemical binding]; other site 630626011945 Walker B motif; other site 630626011946 arginine finger; other site 630626011947 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 630626011948 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 630626011949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 630626011950 FeS/SAM binding site; other site 630626011951 HemN C-terminal domain; Region: HemN_C; pfam06969 630626011952 Der GTPase activator; Provisional; Region: PRK05244 630626011953 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 630626011954 G1 box; other site 630626011955 GTP/Mg2+ binding site [chemical binding]; other site 630626011956 Switch I region; other site 630626011957 G2 box; other site 630626011958 G3 box; other site 630626011959 Switch II region; other site 630626011960 G4 box; other site 630626011961 G5 box; other site 630626011962 DNA polymerase I; Provisional; Region: PRK05755 630626011963 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 630626011964 active site 630626011965 metal binding site 1 [ion binding]; metal-binding site 630626011966 putative 5' ssDNA interaction site; other site 630626011967 metal binding site 3; metal-binding site 630626011968 metal binding site 2 [ion binding]; metal-binding site 630626011969 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 630626011970 putative DNA binding site [nucleotide binding]; other site 630626011971 putative metal binding site [ion binding]; other site 630626011972 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 630626011973 active site 630626011974 catalytic site [active] 630626011975 substrate binding site [chemical binding]; other site 630626011976 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 630626011977 active site 630626011978 DNA binding site [nucleotide binding] 630626011979 catalytic site [active] 630626011980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 630626011981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 630626011982 putative acyl-acceptor binding pocket; other site 630626011983 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 630626011984 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 630626011985 catalytic residues [active] 630626011986 hinge region; other site 630626011987 alpha helical domain; other site 630626011988 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 630626011989 serine/threonine protein kinase; Provisional; Region: PRK11768 630626011990 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 630626011991 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 630626011992 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 630626011993 GTP binding site; other site 630626011994 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 630626011995 Walker A motif; other site 630626011996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 630626011997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 630626011998 DNA-binding site [nucleotide binding]; DNA binding site 630626011999 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 630626012000 transcriptional repressor RbsR; Provisional; Region: PRK10423 630626012001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 630626012002 DNA binding site [nucleotide binding] 630626012003 domain linker motif; other site 630626012004 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 630626012005 dimerization interface [polypeptide binding]; other site 630626012006 ligand binding site [chemical binding]; other site 630626012007 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 630626012008 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 630626012009 substrate binding site [chemical binding]; other site 630626012010 dimer interface [polypeptide binding]; other site 630626012011 ATP binding site [chemical binding]; other site 630626012012 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 630626012013 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 630626012014 ligand binding site [chemical binding]; other site 630626012015 dimerization interface [polypeptide binding]; other site 630626012016 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 630626012017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 630626012018 TM-ABC transporter signature motif; other site 630626012019 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 630626012020 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 630626012021 Walker A/P-loop; other site 630626012022 ATP binding site [chemical binding]; other site 630626012023 Q-loop/lid; other site 630626012024 ABC transporter signature motif; other site 630626012025 Walker B; other site 630626012026 D-loop; other site 630626012027 H-loop/switch region; other site 630626012028 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 630626012029 D-ribose pyranase; Provisional; Region: PRK11797 630626012030 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 630626012031 potassium uptake protein; Region: kup; TIGR00794 630626012032 regulatory ATPase RavA; Provisional; Region: PRK13531 630626012033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 630626012034 Walker A motif; other site 630626012035 ATP binding site [chemical binding]; other site 630626012036 Walker B motif; other site 630626012037 arginine finger; other site 630626012038 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 630626012039 hypothetical protein; Provisional; Region: yieM; PRK10997 630626012040 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 630626012041 metal ion-dependent adhesion site (MIDAS); other site 630626012042 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 630626012043 Citrate transporter; Region: CitMHS; pfam03600 630626012044 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 630626012045 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 630626012046 catalytic site [active] 630626012047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 630626012048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 630626012049 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 630626012050 putative dimerization interface [polypeptide binding]; other site 630626012051 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 630626012052 motif 1; other site 630626012053 dimer interface [polypeptide binding]; other site 630626012054 active site 630626012055 motif 2; other site 630626012056 motif 3; other site 630626012057 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 630626012058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 630626012059 putative DNA binding site [nucleotide binding]; other site 630626012060 putative Zn2+ binding site [ion binding]; other site 630626012061 AsnC family; Region: AsnC_trans_reg; pfam01037 630626012062 FMN-binding protein MioC; Provisional; Region: PRK09004 630626012063 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 630626012064 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 630626012065 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 630626012066 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 630626012067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 630626012068 S-adenosylmethionine binding site [chemical binding]; other site 630626012069 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 630626012070 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 630626012071 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 630626012072 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 630626012073 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 630626012074 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 630626012075 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 630626012076 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 630626012077 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 630626012078 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 630626012079 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 630626012080 beta subunit interaction interface [polypeptide binding]; other site 630626012081 Walker A motif; other site 630626012082 ATP binding site [chemical binding]; other site 630626012083 Walker B motif; other site 630626012084 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 630626012085 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 630626012086 core domain interface [polypeptide binding]; other site 630626012087 delta subunit interface [polypeptide binding]; other site 630626012088 epsilon subunit interface [polypeptide binding]; other site 630626012089 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 630626012090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 630626012091 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 630626012092 alpha subunit interaction interface [polypeptide binding]; other site 630626012093 Walker A motif; other site 630626012094 ATP binding site [chemical binding]; other site 630626012095 Walker B motif; other site 630626012096 inhibitor binding site; inhibition site 630626012097 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 630626012098 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 630626012099 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 630626012100 gamma subunit interface [polypeptide binding]; other site 630626012101 epsilon subunit interface [polypeptide binding]; other site 630626012102 LBP interface [polypeptide binding]; other site 630626012103 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 630626012104 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 630626012105 Substrate binding site; other site 630626012106 Mg++ binding site; other site 630626012107 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 630626012108 active site 630626012109 substrate binding site [chemical binding]; other site 630626012110 CoA binding site [chemical binding]; other site 630626012111 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 630626012112 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 630626012113 glutaminase active site [active] 630626012114 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 630626012115 dimer interface [polypeptide binding]; other site 630626012116 active site 630626012117 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 630626012118 dimer interface [polypeptide binding]; other site 630626012119 active site 630626012120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 630626012121 Coenzyme A binding pocket [chemical binding]; other site 630626012122 acyl-CoA synthetase; Validated; Region: PRK09192 630626012123 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 630626012124 acyl-activating enzyme (AAE) consensus motif; other site 630626012125 active site 630626012126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 630626012127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 630626012128 NAD(P) binding site [chemical binding]; other site 630626012129 active site 630626012130 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 630626012131 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 630626012132 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 630626012133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 630626012134 catalytic residue [active] 630626012135 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 630626012136 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 630626012137 Predicted permeases [General function prediction only]; Region: COG0795 630626012138 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 630626012139 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 630626012140 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 630626012141 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 630626012142 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 630626012143 active site 630626012144 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 630626012145 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 630626012146 TMP-binding site; other site 630626012147 ATP-binding site [chemical binding]; other site 630626012148 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 630626012149 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 630626012150 TMP-binding site; other site 630626012151 ATP-binding site [chemical binding]; other site 630626012152 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 630626012153 DNA-binding site [nucleotide binding]; DNA binding site 630626012154 RNA-binding motif; other site 630626012155 outer membrane porin, OprD family; Region: OprD; pfam03573 630626012156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 630626012157 substrate binding pocket [chemical binding]; other site 630626012158 membrane-bound complex binding site; other site 630626012159 hinge residues; other site 630626012160 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 630626012161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626012162 dimer interface [polypeptide binding]; other site 630626012163 conserved gate region; other site 630626012164 putative PBP binding loops; other site 630626012165 ABC-ATPase subunit interface; other site 630626012166 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 630626012167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 630626012168 dimer interface [polypeptide binding]; other site 630626012169 conserved gate region; other site 630626012170 putative PBP binding loops; other site 630626012171 ABC-ATPase subunit interface; other site 630626012172 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 630626012173 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 630626012174 Walker A/P-loop; other site 630626012175 ATP binding site [chemical binding]; other site 630626012176 Q-loop/lid; other site 630626012177 ABC transporter signature motif; other site 630626012178 Walker B; other site 630626012179 D-loop; other site 630626012180 H-loop/switch region; other site 630626012181 transcriptional regulator PhoU; Provisional; Region: PRK11115 630626012182 PhoU domain; Region: PhoU; pfam01895 630626012183 PhoU domain; Region: PhoU; pfam01895 630626012184 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 630626012185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 630626012186 active site 630626012187 motif I; other site 630626012188 motif II; other site 630626012189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 630626012190 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 630626012191 Probable transposase; Region: OrfB_IS605; pfam01385 630626012192 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 630626012193 Transposase IS200 like; Region: Y1_Tnp; pfam01797 630626012194 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 630626012195 Predicted membrane protein [Function unknown]; Region: COG3503 630626012196 Predicted flavoprotein [General function prediction only]; Region: COG0431 630626012197 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 630626012198 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 630626012199 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 630626012200 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 630626012201 trmE is a tRNA modification GTPase; Region: trmE; cd04164 630626012202 G1 box; other site 630626012203 GTP/Mg2+ binding site [chemical binding]; other site 630626012204 Switch I region; other site 630626012205 G2 box; other site 630626012206 Switch II region; other site 630626012207 G3 box; other site 630626012208 G4 box; other site 630626012209 G5 box; other site 630626012210 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 630626012211 membrane protein insertase; Provisional; Region: PRK01318 630626012212 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 630626012213 Haemolytic domain; Region: Haemolytic; cl00506 630626012214 ribonuclease P; Reviewed; Region: rnpA; PRK01732 630626012215 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399