-- dump date 20140619_080624 -- class Genbank::misc_feature -- table misc_feature_note -- id note 216592000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 216592000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 216592000003 putative catalytic residues [active] 216592000004 putative nucleotide binding site [chemical binding]; other site 216592000005 putative aspartate binding site [chemical binding]; other site 216592000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 216592000007 dimer interface [polypeptide binding]; other site 216592000008 putative threonine allosteric regulatory site; other site 216592000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 216592000010 putative threonine allosteric regulatory site; other site 216592000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216592000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216592000013 HMMPfam hit to PF00696, Amino acid kinase family, score 7.4e-67 216592000014 PS00324 Aspartokinase signature. 216592000015 HMMPfam hit to PF01842, ACT domain, score 8.3e-08 216592000016 HMMPfam hit to PF01842, ACT domain, score 1.1e-09 216592000017 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 3.2e-63 216592000018 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 5.9e-107 216592000019 PS01042 Homoserine dehydrogenase signature. 216592000020 homoserine kinase; Region: thrB; TIGR00191 216592000021 Protein of unknown function; Region: YhfT; pfam10797 216592000022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216592000023 HMMPfam hit to PF00288, GHMP kinases putative ATP-binding protei, score 2.7e-40 216592000024 PS00627 GHMP kinases putative ATP-binding domain. 216592000025 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 216592000026 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 216592000027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592000028 catalytic residue [active] 216592000029 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 4.5e-31 216592000030 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216592000031 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 216592000032 Signal peptide predicted for EC042_0004 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 216592000033 1 probable transmembrane helix predicted for EC042_0004 by TMHMM2.0 at aa 7-29 216592000034 HTH-like domain; Region: HTH_21; pfam13276 216592000035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592000036 Integrase core domain; Region: rve; pfam00665 216592000037 Integrase core domain; Region: rve_2; pfam13333 216592000038 HMMPfam hit to PF00665, Integrase core domain, score 7.6e-45 216592000039 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592000041 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592000042 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592000043 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 20-41, sequence AGIISTAKLFQLSHTSLSHWIN 216592000044 hypothetical protein; Validated; Region: PRK02101 216592000045 HMMPfam hit to PF03883, Protein of unknown function (DUF328), score 1.5e-187 216592000046 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592000047 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 216592000048 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 216592000049 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.6e-290 216592000050 9 probable transmembrane helices predicted for EC042_0008 by TMHMM2.0 at aa 13-35, 76-98, 139-161, 174-196, 206-228, 301-323, 343-365, 386-408 and 412-434 216592000051 PS00873 Sodium:alanine symporter family signature. 216592000052 transaldolase-like protein; Provisional; Region: PTZ00411 216592000053 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 216592000054 active site 216592000055 dimer interface [polypeptide binding]; other site 216592000056 catalytic residue [active] 216592000057 HMMPfam hit to PF00923, Transaldolase, score 2.6e-183 216592000058 PS01054 Transaldolase signature 1. 216592000059 PS00958 Transaldolase active site. 216592000060 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 216592000061 MPT binding site; other site 216592000062 trimer interface [polypeptide binding]; other site 216592000063 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 2.9e-41 216592000064 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 216592000065 hypothetical protein; Provisional; Region: PRK10659 216592000066 HMMPfam hit to PF01184, GPR1/FUN34/yaaH family, score 8.8e-130 216592000067 6 probable transmembrane helices predicted for EC042_0011 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118, 125-144 and 148-170 216592000068 PS01114 GPR1/FUN34/yaaH family signature. 216592000069 hypothetical protein; Provisional; Region: PRK10236 216592000070 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 216592000071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 216592000072 HMMPfam hit to PF03667, Uncharacterised protein family (UPF0174), score 5.4e-147 216592000073 hypothetical protein; Provisional; Region: PRK10154 216592000074 Signal peptide predicted for EC042_0013 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.950 between residues 23 and 24 216592000075 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 216592000076 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 216592000077 nucleotide binding site [chemical binding]; other site 216592000078 NEF interaction site [polypeptide binding]; other site 216592000079 SBD interface [polypeptide binding]; other site 216592000080 HMMPfam hit to PF00012, Hsp70 protein, score 0 216592000081 PS00297 Heat shock hsp70 proteins family signature 1. 216592000082 PS00329 Heat shock hsp70 proteins family signature 2. 216592000083 PS01036 Heat shock hsp70 proteins family signature 3. 216592000084 chaperone protein DnaJ; Provisional; Region: PRK10767 216592000085 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216592000086 HSP70 interaction site [polypeptide binding]; other site 216592000087 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 216592000088 substrate binding site [polypeptide binding]; other site 216592000089 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216592000090 Zn binding sites [ion binding]; other site 216592000091 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216592000092 dimer interface [polypeptide binding]; other site 216592000093 HMMPfam hit to PF00226, DnaJ domain, score 5.8e-41 216592000094 PS00636 Nt-dnaJ domain signature. 216592000095 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.1e-49 216592000096 PS00637 CXXCXGXG dnaJ domain signature. 216592000097 PS00190 Cytochrome c family heme-binding site signature. 216592000098 PS00190 Cytochrome c family heme-binding site signature. 216592000099 HMMPfam hit to PF01556, DnaJ C terminal region, score 3.3e-76 216592000100 Hok/gef family; Region: HOK_GEF; pfam01848 216592000101 HMMPfam hit to PF01848, Hok/gef family, score 2.5e-26 216592000102 PS00556 Hok/gef family cell toxic proteins signature. 216592000103 1 probable transmembrane helix predicted for EC042_0016 by TMHMM2.0 at aa 36-55 216592000104 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 216592000105 Signal peptide predicted for EC042_0017 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.506 between residues 33 and 34 216592000106 HMMPfam hit to PF06965, Na+/H+ antiporter, score 3.8e-261 216592000107 11 probable transmembrane helices predicted for EC042_0017 by TMHMM2.0 at aa 7-29, 59-76, 96-115, 125-147, 154-176, 180-202, 215-237, 257-279, 291-313, 328-350 and 357-379 216592000108 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 216592000109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592000110 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 216592000111 putative dimerization interface [polypeptide binding]; other site 216592000112 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 1e-17 216592000113 PS00044 Bacterial regulatory proteins, lysR family signature. 216592000114 Fimbrial operon 1 and type III effector. Absent in UPEC, APEC, EPEC. Present in EHEC. 216592000115 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 216592000116 HMMPfam hit to PF03400, IS1 transposase, score 1e-103 216592000117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592000118 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592000119 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592000120 HMMPfam hit to PF03811, Insertion element protein, score 9.5e-70 216592000121 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592000122 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000123 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 216592000124 PapC N-terminal domain; Region: PapC_N; pfam13954 216592000125 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592000126 PapC C-terminal domain; Region: PapC_C; pfam13953 216592000127 HMMPfam hit to PF00577, Fimbrial Usher protein, score 1.4e-278 216592000128 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592000129 Signal peptide predicted for EC042_0022 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.996 between residues 21 and 22 216592000130 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592000131 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592000132 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 4.9e-09 216592000133 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 2.2e-36 216592000134 PS00635 Gram-negative pili assembly chaperone signature. 216592000135 Fimbrial protein; Region: Fimbrial; cl01416 216592000136 HMMPfam hit to PF00419, Fimbrial protein, score 0.00066 216592000137 Signal peptide predicted for EC042_0024 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592000138 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 216592000139 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 216592000140 HMMPfam hit to PF01649, Ribosomal protein S20, score 5.9e-46 216592000141 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 216592000142 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 216592000143 active site 216592000144 Riboflavin kinase; Region: Flavokinase; smart00904 216592000145 HMMPfam hit to PF06574, Riboflavin kinase (Flavokinase), score 5.4e-86 216592000146 HMMPfam hit to PF01687, Riboflavin kinase / FAD synthetase, score 4e-69 216592000147 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 216592000148 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216592000149 HIGH motif; other site 216592000150 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216592000151 active site 216592000152 KMSKS motif; other site 216592000153 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 216592000154 tRNA binding surface [nucleotide binding]; other site 216592000155 anticodon binding site; other site 216592000156 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216592000157 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 216592000158 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592000159 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 5.2e-14 216592000160 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 216592000161 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 9.1e-91 216592000162 4 probable transmembrane helices predicted for EC042_0029 by TMHMM2.0 at aa 13-35, 67-86, 99-121 and 136-158 216592000163 PS00855 Signal peptidases II signature. 216592000164 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 216592000165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216592000166 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 2.6e-10 216592000167 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216592000168 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216592000169 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 216592000170 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 216592000171 HMMPfam hit to PF02401, LytB protein, score 1e-192 216592000172 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216592000173 active site 216592000174 tetramer interface [polypeptide binding]; other site 216592000175 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 1.4e-177 216592000176 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 216592000177 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 216592000178 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216592000179 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216592000180 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 3.3e-60 216592000181 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 2.1e-82 216592000182 PS01298 Dihydrodipicolinate reductase signature. 216592000183 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 216592000184 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 216592000185 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 216592000186 catalytic site [active] 216592000187 subunit interface [polypeptide binding]; other site 216592000188 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 2.3e-93 216592000189 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 9.9e-76 216592000190 PS00442 Glutamine amidotransferases class-I active site. 216592000191 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 216592000192 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216592000193 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216592000194 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 216592000195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216592000196 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216592000197 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 216592000198 IMP binding site; other site 216592000199 dimer interface [polypeptide binding]; other site 216592000200 interdomain contacts; other site 216592000201 partial ornithine binding site; other site 216592000202 Signal peptide predicted for EC042_0035 by SignalP 2.0 HMM (Signal peptide probability 0.767) with cleavage site probability 0.700 between residues 23 and 24 216592000203 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 6.1e-64 216592000204 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592000205 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 3.2e-136 216592000206 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216592000207 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216592000208 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 3.4e-68 216592000209 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 2.9e-25 216592000210 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.5e-26 216592000211 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216592000212 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216592000213 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000214 HMMPfam hit to PF02142, MGS-like domain, score 6.2e-32 216592000215 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 216592000216 carnitine operon protein CaiE; Provisional; Region: PRK13627 216592000217 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 216592000218 putative trimer interface [polypeptide binding]; other site 216592000219 putative metal binding site [ion binding]; other site 216592000220 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.014 216592000221 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 12 216592000222 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1 216592000223 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 216592000224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216592000225 substrate binding site [chemical binding]; other site 216592000226 oxyanion hole (OAH) forming residues; other site 216592000227 trimer interface [polypeptide binding]; other site 216592000228 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.3e-87 216592000229 PS00166 Enoyl-CoA hydratase/isomerase signature. 216592000230 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592000231 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 216592000232 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 216592000233 acyl-activating enzyme (AAE) consensus motif; other site 216592000234 putative AMP binding site [chemical binding]; other site 216592000235 putative active site [active] 216592000236 putative CoA binding site [chemical binding]; other site 216592000237 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.4e-124 216592000238 PS00455 Putative AMP-binding domain signature. 216592000239 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 216592000240 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216592000241 HMMPfam hit to PF02515, CoA-transferase family III, score 1.1e-97 216592000242 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 216592000243 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216592000244 active site 216592000245 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 9.7e-60 216592000246 PS00073 Acyl-CoA dehydrogenases signature 2. 216592000247 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 3.8e-58 216592000248 PS00072 Acyl-CoA dehydrogenases signature 1. 216592000249 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 3.4e-53 216592000250 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 216592000251 HMMPfam hit to PF02028, BCCT family transporter, score 0 216592000252 12 probable transmembrane helices predicted for EC042_0042 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 141-163, 195-214, 229-251, 264-286, 312-334, 347-366, 410-432, 445-467 and 472-494 216592000253 PS01303 BCCT family of transporters signature. 216592000254 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216592000255 Ligand binding site [chemical binding]; other site 216592000256 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216592000257 HMMPfam hit to PF01012, Electron transfer flavoprotein beta subunit, score 3.4e-113 216592000258 PS01065 Electron transfer flavoprotein beta-subunit signature. 216592000259 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 216592000260 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 216592000261 Ligand binding site [chemical binding]; other site 216592000262 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216592000263 HMMPfam hit to PF00766, Electron transfer flavoprotein alpha subuni, score 1.6e-126 216592000264 PS00696 Electron transfer flavoprotein alpha-subunit signature. 216592000265 putative oxidoreductase FixC; Provisional; Region: PRK10157 216592000266 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.6e-14 216592000267 ferredoxin-like protein FixX; Provisional; Region: PRK15449 216592000268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592000269 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 216592000270 putative substrate translocation pore; other site 216592000271 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.8e-43 216592000272 12 probable transmembrane helices predicted for EC042_0047 by TMHMM2.0 at aa 19-41, 54-76, 85-104, 109-131, 144-166, 171-193, 244-266, 281-303, 310-329, 335-357, 370-392 and 402-421 216592000273 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.8e-32 216592000274 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 216592000275 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.1e-67 216592000276 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 216592000277 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 216592000278 TrkA-N domain; Region: TrkA_N; pfam02254 216592000279 13 probable transmembrane helices predicted for EC042_0049 by TMHMM2.0 at aa 37-56, 58-77, 87-104, 117-139, 144-166, 179-201, 211-233, 246-265, 269-286, 299-321, 325-347, 359-381 and 391-413 216592000280 HMMPfam hit to PF02254, TrkA-N domain, score 3e-20 216592000281 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216592000282 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 216592000283 folate binding site [chemical binding]; other site 216592000284 NADP+ binding site [chemical binding]; other site 216592000285 HMMPfam hit to PF00186, Dihydrofolate reductase, score 5e-57 216592000286 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592000287 PS00075 Dihydrofolate reductase signature. 216592000288 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 216592000289 HMMPfam hit to PF07362, Post-segregation antitoxin CcdA, score 1.1e-50 216592000290 CcdB protein; Region: CcdB; pfam01845 216592000291 HMMPfam hit to PF01845, CcdB protein, score 4.1e-10 216592000292 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 216592000293 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 216592000294 active site 216592000295 metal binding site [ion binding]; metal-binding site 216592000296 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.8e-18 216592000297 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 216592000298 HMMPfam hit to PF04379, Protein of unknown function (DUF525), score 2.6e-78 216592000299 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 216592000300 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 216592000301 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 1.4e-110 216592000302 PS01131 Ribosomal RNA adenine dimethylases signature. 216592000303 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 216592000304 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 216592000305 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 1.3e-187 216592000306 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 216592000307 SurA N-terminal domain; Region: SurA_N; pfam09312 216592000308 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216592000309 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216592000310 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 3.4e-51 216592000311 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216592000312 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000313 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 2.6e-45 216592000314 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216592000315 Signal peptide predicted for EC042_0057 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 216592000316 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 216592000317 OstA-like protein; Region: OstA; pfam03968 216592000318 Organic solvent tolerance protein; Region: OstA_C; pfam04453 216592000319 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 2e-178 216592000320 Signal peptide predicted for EC042_0058 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 24 and 25 216592000321 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 216592000322 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 216592000323 putative metal binding site [ion binding]; other site 216592000324 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216592000325 HSP70 interaction site [polypeptide binding]; other site 216592000326 1 probable transmembrane helix predicted for EC042_0059 by TMHMM2.0 at aa 22-44 216592000327 HMMPfam hit to PF00226, DnaJ domain, score 1.9e-14 216592000328 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216592000329 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216592000330 active site 216592000331 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.6e-62 216592000332 PS01129 Rlu family of pseudouridine synthase signature. 216592000333 ATP-dependent helicase HepA; Validated; Region: PRK04914 216592000334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592000335 ATP binding site [chemical binding]; other site 216592000336 putative Mg++ binding site [ion binding]; other site 216592000337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592000338 nucleotide binding region [chemical binding]; other site 216592000339 ATP-binding site [chemical binding]; other site 216592000340 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.4e-20 216592000341 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 2e-91 216592000342 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 5.6e-06 216592000343 DNA polymerase II; Reviewed; Region: PRK05762 216592000344 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 216592000345 active site 216592000346 catalytic site [active] 216592000347 substrate binding site [chemical binding]; other site 216592000348 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 216592000349 active site 216592000350 metal-binding site 216592000351 HMMPfam hit to PF00136, DNA polymerase family B, score 3.1e-95 216592000352 PS00116 DNA polymerase family B signature. 216592000353 HMMPfam hit to PF03104, DNA polymerase family B, exonuclease do, score 3e-59 216592000354 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 216592000355 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 216592000356 intersubunit interface [polypeptide binding]; other site 216592000357 active site 216592000358 Zn2+ binding site [ion binding]; other site 216592000359 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 3.1e-105 216592000360 L-arabinose isomerase; Provisional; Region: PRK02929 216592000361 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 216592000362 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 216592000363 trimer interface [polypeptide binding]; other site 216592000364 putative substrate binding site [chemical binding]; other site 216592000365 putative metal binding site [ion binding]; other site 216592000366 HMMPfam hit to PF02610, L-arabinose isomerase, score 0 216592000367 ribulokinase; Provisional; Region: PRK04123 216592000368 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 216592000369 N- and C-terminal domain interface [polypeptide binding]; other site 216592000370 active site 216592000371 MgATP binding site [chemical binding]; other site 216592000372 catalytic site [active] 216592000373 metal binding site [ion binding]; metal-binding site 216592000374 carbohydrate binding site [chemical binding]; other site 216592000375 homodimer interface [polypeptide binding]; other site 216592000376 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.7e-06 216592000377 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 216592000378 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216592000379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592000380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592000381 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 1.4e-29 216592000382 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 1.1e-11 216592000383 Predicted helix-turn-helix motif with score 1779.000, SD 5.25 at aa 207-228, sequence FDIASVAQHVCLSPSRLSHLFR 216592000384 PS00041 Bacterial regulatory proteins, araC family signature. 216592000385 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.1e-13 216592000386 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216592000387 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216592000388 HMMPfam hit to PF00597, DedA family, score 5.5e-64 216592000389 5 probable transmembrane helices predicted for EC042_0068 by TMHMM2.0 at aa 20-42, 57-79, 147-169, 179-196 and 217-236 216592000390 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 216592000391 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 216592000392 Walker A/P-loop; other site 216592000393 ATP binding site [chemical binding]; other site 216592000394 Q-loop/lid; other site 216592000395 ABC transporter signature motif; other site 216592000396 Walker B; other site 216592000397 D-loop; other site 216592000398 H-loop/switch region; other site 216592000399 HMMPfam hit to PF00005, ABC transporter, score 2e-72 216592000400 PS00211 ABC transporters family signature. 216592000401 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000402 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 216592000403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592000404 dimer interface [polypeptide binding]; other site 216592000405 conserved gate region; other site 216592000406 putative PBP binding loops; other site 216592000407 ABC-ATPase subunit interface; other site 216592000408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592000409 dimer interface [polypeptide binding]; other site 216592000410 conserved gate region; other site 216592000411 putative PBP binding loops; other site 216592000412 ABC-ATPase subunit interface; other site 216592000413 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.00051 216592000414 12 probable transmembrane helices predicted for EC042_0070 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 132-151, 199-221, 241-260, 293-315, 335-357, 370-392, 407-424, 462-484 and 508-525 216592000415 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.7e-07 216592000416 Signal peptide predicted for EC042_0070 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.425 between residues 29 and 30 216592000417 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 216592000418 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 216592000419 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 216592000420 Signal peptide predicted for EC042_0071 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 216592000421 transcriptional regulator SgrR; Provisional; Region: PRK13626 216592000422 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 216592000423 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 216592000424 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.2e-57 216592000425 Predicted helix-turn-helix motif with score 1207.000, SD 3.30 at aa 31-52, sequence TTLNELAALLSCSRRHMRTLLN 216592000426 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 216592000427 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 216592000428 substrate binding site [chemical binding]; other site 216592000429 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 1.4e-67 216592000430 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 216592000431 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 216592000432 substrate binding site [chemical binding]; other site 216592000433 ligand binding site [chemical binding]; other site 216592000434 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 9.5e-292 216592000435 PS01244 Aconitase family signature 2. 216592000436 PS00450 Aconitase family signature 1. 216592000437 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 216592000438 tartrate dehydrogenase; Region: TTC; TIGR02089 216592000439 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 8.5e-224 216592000440 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216592000441 2-isopropylmalate synthase; Validated; Region: PRK00915 216592000442 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 216592000443 active site 216592000444 catalytic residues [active] 216592000445 metal binding site [ion binding]; metal-binding site 216592000446 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 216592000447 HMMPfam hit to PF00682, HMGL-like, score 3.2e-153 216592000448 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 216592000449 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 216592000450 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 216592000451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592000452 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 216592000453 putative substrate binding pocket [chemical binding]; other site 216592000454 putative dimerization interface [polypeptide binding]; other site 216592000455 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.3e-18 216592000456 Predicted helix-turn-helix motif with score 1727.000, SD 5.07 at aa 65-86, sequence QNITRAAHVLGMSQPAVSNAVA 216592000457 PS00044 Bacterial regulatory proteins, lysR family signature. 216592000458 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.1e-09 216592000459 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592000460 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 216592000461 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216592000462 PYR/PP interface [polypeptide binding]; other site 216592000463 dimer interface [polypeptide binding]; other site 216592000464 TPP binding site [chemical binding]; other site 216592000465 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216592000466 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216592000467 TPP-binding site [chemical binding]; other site 216592000468 dimer interface [polypeptide binding]; other site 216592000469 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 3e-104 216592000470 PS00044 Bacterial regulatory proteins, lysR family signature. 216592000471 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 2.5e-82 216592000472 PS00187 Thiamine pyrophosphate enzymes signature. 216592000473 PS00430 TonB-dependent receptor proteins signature 1. 216592000474 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 216592000475 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 216592000476 putative valine binding site [chemical binding]; other site 216592000477 dimer interface [polypeptide binding]; other site 216592000478 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 216592000479 HMMPfam hit to PF01842, ACT domain, score 1.5e-16 216592000480 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 216592000481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592000482 DNA binding site [nucleotide binding] 216592000483 domain linker motif; other site 216592000484 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 216592000485 dimerization interface [polypeptide binding]; other site 216592000486 ligand binding site [chemical binding]; other site 216592000487 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.6e-09 216592000488 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 1-22, sequence MKLDEIARLAGVSRTTASYVIN 216592000489 PS00356 Bacterial regulatory proteins, lacI family signature. 216592000490 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3.2e-05 216592000491 mraZ protein; Region: TIGR00242 216592000492 MraZ protein; Region: MraZ; pfam02381 216592000493 MraZ protein; Region: MraZ; pfam02381 216592000494 HMMPfam hit to PF02381, Domain of unknown function UPF0040 family, score 4.1e-30 216592000495 HMMPfam hit to PF02381, Domain of unknown function UPF0040 family, score 2.7e-24 216592000496 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 216592000497 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 216592000498 HMMPfam hit to PF01795, MraW methylase family, score 1.5e-196 216592000499 cell division protein FtsL; Provisional; Region: PRK10772 216592000500 HMMPfam hit to PF04999, Cell division protein FtsL, score 1.1e-65 216592000501 1 probable transmembrane helix predicted for EC042_0084 by TMHMM2.0 at aa 35-57 216592000502 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 216592000503 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216592000504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216592000505 Signal peptide predicted for EC042_0085 by SignalP 2.0 HMM (Signal peptide probability 0.957) with cleavage site probability 0.576 between residues 45 and 46 216592000506 1 probable transmembrane helix predicted for EC042_0085 by TMHMM2.0 at aa 21-43 216592000507 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 7.7e-69 216592000508 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.7e-120 216592000509 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 216592000510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216592000511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592000512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592000513 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.2e-87 216592000514 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.5e-39 216592000515 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 216592000516 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216592000517 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592000518 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592000519 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 7e-84 216592000520 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.3e-20 216592000521 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592000522 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 216592000523 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 216592000524 Mg++ binding site [ion binding]; other site 216592000525 putative catalytic motif [active] 216592000526 putative substrate binding site [chemical binding]; other site 216592000527 10 probable transmembrane helices predicted for EC042_0088 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 216592000528 HMMPfam hit to PF00953, Glycosyl transferase, score 8.1e-88 216592000529 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 216592000530 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592000531 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592000532 1 probable transmembrane helix predicted for EC042_0089 by TMHMM2.0 at aa 9-31 216592000533 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592000534 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.9e-66 216592000535 PS00012 Phosphopantetheine attachment site. 216592000536 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1e-17 216592000537 cell division protein FtsW; Provisional; Region: PRK10774 216592000538 HMMPfam hit to PF01098, Cell cycle protein, score 4.2e-194 216592000539 8 probable transmembrane helices predicted for EC042_0090 by TMHMM2.0 at aa 50-72, 87-104, 111-133, 185-207, 220-242, 308-330, 342-364 and 374-396 216592000540 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 216592000541 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 216592000542 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 216592000543 active site 216592000544 homodimer interface [polypeptide binding]; other site 216592000545 HMMPfam hit to PF03033, Glycosyltransferase family, score 9.2e-54 216592000546 HMMPfam hit to PF04101, Glycosyltransferase family, score 2.7e-59 216592000547 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 216592000548 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216592000549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592000550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592000551 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.6e-68 216592000552 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 1.3e-22 216592000553 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 216592000554 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216592000555 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 216592000556 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 1.3e-47 216592000557 PS00843 D-alanine--D-alanine ligase signature 1. 216592000558 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592000559 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 2.7e-119 216592000560 PS00844 D-alanine--D-alanine ligase signature 2. 216592000561 cell division protein FtsQ; Provisional; Region: PRK10775 216592000562 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 216592000563 Cell division protein FtsQ; Region: FtsQ; pfam03799 216592000564 1 probable transmembrane helix predicted for EC042_0094 by TMHMM2.0 at aa 25-47 216592000565 HMMPfam hit to PF03799, Cell division protein FtsQ, score 6.9e-79 216592000566 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 216592000567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592000568 Cell division protein FtsA; Region: FtsA; pfam14450 216592000569 HMMPfam hit to PF02491, Cell division protein FtsA, score 1.8e-74 216592000570 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.9e-70 216592000571 cell division protein FtsZ; Validated; Region: PRK09330 216592000572 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 216592000573 nucleotide binding site [chemical binding]; other site 216592000574 SulA interaction site; other site 216592000575 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 1.1e-89 216592000576 PS01134 FtsZ protein signature 1. 216592000577 PS01135 FtsZ protein signature 2. 216592000578 HMMPfam hit to PF03953, Tubulin/FtsZ family, C-terminal domain, score 1.3e-45 216592000579 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 216592000580 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 216592000581 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 2.4e-194 216592000582 SecA regulator SecM; Provisional; Region: PRK02943 216592000583 HMMPfam hit to PF06558, Secretion monitor precursor protein (SecM), score 5.4e-114 216592000584 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 216592000585 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 216592000586 SEC-C motif; Region: SEC-C; pfam02810 216592000587 HMMPfam hit to PF07517, SecA DEAD-like domain, score 7.2e-160 216592000588 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 1.1e-85 216592000589 PS01312 Protein secA signatures. 216592000590 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 3e-125 216592000591 HMMPfam hit to PF02810, SEC-C motif, score 6e-11 216592000592 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216592000593 active site 216592000594 8-oxo-dGMP binding site [chemical binding]; other site 216592000595 nudix motif; other site 216592000596 metal binding site [ion binding]; metal-binding site 216592000597 HMMPfam hit to PF00293, NUDIX domain, score 1.9e-27 216592000598 PS00893 mutT domain signature. 216592000599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 216592000600 HMMPfam hit to PF07072, Protein of unknown function (DUF1342), score 1.1e-171 216592000601 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 216592000602 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 216592000603 CoA-binding site [chemical binding]; other site 216592000604 ATP-binding [chemical binding]; other site 216592000605 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 3e-119 216592000606 PS01294 Uncharacterized protein family UPF0038 signature. 216592000607 Signal peptide predicted for EC042_0102 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.491 between residues 23 and 24 216592000608 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000609 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 216592000610 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216592000611 active site 216592000612 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 4.5e-158 216592000613 PS00487 IMP dehydrogenase / GMP reductase signature. 216592000614 type IV pilin biogenesis protein; Provisional; Region: PRK10573 216592000615 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216592000616 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216592000617 3 probable transmembrane helices predicted for EC042_0104 by TMHMM2.0 at aa 163-185, 216-235 and 368-390 216592000618 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.9e-16 216592000619 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.1e-21 216592000620 PS00874 Bacterial type II secretion system protein F signature. 216592000621 hypothetical protein; Provisional; Region: PRK10436 216592000622 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216592000623 Walker A motif; other site 216592000624 ATP binding site [chemical binding]; other site 216592000625 Walker B motif; other site 216592000626 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 5.3e-143 216592000627 PS00662 Bacterial type II secretion system protein E signature. 216592000628 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000629 putative major pilin subunit; Provisional; Region: PRK10574 216592000630 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 216592000631 Pilin (bacterial filament); Region: Pilin; pfam00114 216592000632 HMMPfam hit to PF00114, Pilin (bacterial filament), score 5.7e-08 216592000633 1 probable transmembrane helix predicted for EC042_0106 by TMHMM2.0 at aa 7-29 216592000634 PS00409 Prokaryotic N-terminal methylation site. 216592000635 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 216592000636 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 216592000637 dimerization interface [polypeptide binding]; other site 216592000638 active site 216592000639 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, C-t, score 1.3e-102 216592000640 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, N-t, score 6.6e-44 216592000641 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 216592000642 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216592000643 amidase catalytic site [active] 216592000644 Zn binding residues [ion binding]; other site 216592000645 substrate binding site [chemical binding]; other site 216592000646 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 8.9e-66 216592000647 regulatory protein AmpE; Provisional; Region: PRK10987 216592000648 4 probable transmembrane helices predicted for EC042_0110 by TMHMM2.0 at aa 39-58, 63-85, 146-168 and 266-283 216592000649 aromatic amino acid transporter; Provisional; Region: PRK10238 216592000650 HMMPfam hit to PF00324, Amino acid permease, score 4.1e-184 216592000651 12 probable transmembrane helices predicted for EC042_0111 by TMHMM2.0 at aa 20-42, 47-66, 87-109, 119-141, 154-176, 199-221, 241-263, 283-305, 332-354, 358-380, 400-422 and 427-446 216592000652 PS00218 Amino acid permeases signature. 216592000653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216592000654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592000655 DNA-binding site [nucleotide binding]; DNA binding site 216592000656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592000657 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.1e-32 216592000658 PS00043 Bacterial regulatory proteins, gntR family signature. 216592000659 Predicted helix-turn-helix motif with score 1327.000, SD 3.71 at aa 35-56, sequence PPERELAKQFDVSRPSLREAIQ 216592000660 HMMPfam hit to PF07729, FCD domain, score 5.8e-31 216592000661 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 216592000662 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 216592000663 dimer interface [polypeptide binding]; other site 216592000664 TPP-binding site [chemical binding]; other site 216592000665 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 216592000666 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216592000667 E3 interaction surface; other site 216592000668 lipoyl attachment site [posttranslational modification]; other site 216592000669 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216592000670 E3 interaction surface; other site 216592000671 lipoyl attachment site [posttranslational modification]; other site 216592000672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216592000673 E3 interaction surface; other site 216592000674 lipoyl attachment site [posttranslational modification]; other site 216592000675 e3 binding domain; Region: E3_binding; pfam02817 216592000676 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216592000677 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1e-27 216592000678 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592000679 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 1.4e-30 216592000680 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592000681 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 4.5e-29 216592000682 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592000683 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000684 HMMPfam hit to PF02817, e3 binding domain, score 1.6e-18 216592000685 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 1.2e-110 216592000686 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 216592000687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216592000688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592000689 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216592000690 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 4.7e-98 216592000691 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216592000692 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 3.1e-52 216592000693 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 216592000694 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 216592000695 Signal peptide predicted for EC042_0116 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.690 between residues 25 and 26 216592000696 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 216592000697 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 216592000698 substrate binding site [chemical binding]; other site 216592000699 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 216592000700 substrate binding site [chemical binding]; other site 216592000701 ligand binding site [chemical binding]; other site 216592000702 HMMPfam hit to PF06434, Aconitate hydratase, score 1.2e-294 216592000703 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 8.5e-09 216592000704 PS00450 Aconitase family signature 1. 216592000705 PS01244 Aconitase family signature 2. 216592000706 hypothetical protein; Provisional; Region: PRK05248 216592000707 HMMPfam hit to PF06062, Uncharacterised protein family (UPF0231), score 2e-77 216592000708 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 216592000709 HMMPfam hit to PF02675, S-adenosylmethionine decarboxylase, score 6.6e-77 216592000710 spermidine synthase; Provisional; Region: PRK00811 216592000711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592000712 S-adenosylmethionine binding site [chemical binding]; other site 216592000713 HMMPfam hit to PF01564, Spermine/spermidine synthase, score 9.3e-135 216592000714 PS01330 Spermidine/spermine synthases family signature. 216592000715 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 216592000716 multicopper oxidase; Provisional; Region: PRK10965 216592000717 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216592000718 Multicopper oxidase; Region: Cu-oxidase; pfam00394 216592000719 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216592000720 Signal peptide predicted for EC042_0122 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 216592000721 HMMPfam hit to PF07732, Multicopper oxidase, score 2.8e-46 216592000722 HMMPfam hit to PF07731, Multicopper oxidase, score 1.2e-18 216592000723 PS00080 Multicopper oxidases signature 2. 216592000724 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 216592000725 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 216592000726 Trp docking motif [polypeptide binding]; other site 216592000727 putative active site [active] 216592000728 HMMPfam hit to PF01011, PQQ enzyme repeat, score 9.8e-08 216592000729 HMMPfam hit to PF01011, PQQ enzyme repeat, score 4.1e-06 216592000730 PS00364 Bacterial quinoprotein dehydrogenases signature 2. 216592000731 HMMPfam hit to PF01011, PQQ enzyme repeat, score 3.2e-09 216592000732 PS00363 Bacterial quinoprotein dehydrogenases signature 1. 216592000733 5 probable transmembrane helices predicted for EC042_0123 by TMHMM2.0 at aa 21-43, 47-64, 69-87, 102-120 and 127-146 216592000734 Signal peptide predicted for EC042_0123 by SignalP 2.0 HMM (Signal peptide probability 0.705) with cleavage site probability 0.309 between residues 44 and 45 216592000735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592000736 active site 216592000737 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3.6e-38 216592000738 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592000739 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 216592000740 active site clefts [active] 216592000741 zinc binding site [ion binding]; other site 216592000742 dimer interface [polypeptide binding]; other site 216592000743 HMMPfam hit to PF00484, Carbonic anhydrase, score 7.6e-59 216592000744 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 216592000745 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 216592000746 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216592000747 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216592000748 Walker A/P-loop; other site 216592000749 ATP binding site [chemical binding]; other site 216592000750 Q-loop/lid; other site 216592000751 ABC transporter signature motif; other site 216592000752 Walker B; other site 216592000753 D-loop; other site 216592000754 H-loop/switch region; other site 216592000755 HMMPfam hit to PF00005, ABC transporter, score 1.5e-53 216592000756 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000757 PS00211 ABC transporters family signature. 216592000758 inner membrane transport permease; Provisional; Region: PRK15066 216592000759 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216592000760 6 probable transmembrane helices predicted for EC042_0127 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 170-192 and 226-248 216592000761 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.2e-47 216592000762 PS00890 ABC-2 type transport system integral membrane proteins signature. 216592000763 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 216592000764 active pocket/dimerization site; other site 216592000765 active site 216592000766 phosphorylation site [posttranslational modification] 216592000767 HMMPfam hit to PF03610, PTS system fructose IIA component, score 5.2e-35 216592000768 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 216592000769 putative active site [active] 216592000770 putative metal binding site [ion binding]; other site 216592000771 Signal peptide predicted for EC042_0129 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.897 between residues 19 and 20 216592000772 1 probable transmembrane helix predicted for EC042_0129 by TMHMM2.0 at aa 5-23 216592000773 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 9e-28 216592000774 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 216592000775 tetramerization interface [polypeptide binding]; other site 216592000776 active site 216592000777 HMMPfam hit to PF02261, Aspartate decarboxylase, score 8.8e-86 216592000778 PS00678 Trp-Asp (WD) repeats signature. 216592000779 Uncharacterized conserved protein [Function unknown]; Region: COG5464 216592000780 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 216592000781 HMMPfam hit to PF04754, Putative transposase, YhgA-like, score 2.4e-196 216592000782 Predicted helix-turn-helix motif with score 1133.000, SD 3.05 at aa 293-314, sequence MSREDVAEMANLPLAEIDKLIN 216592000783 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 216592000784 Predicted helix-turn-helix motif with score 1009.000, SD 2.62 at aa 48-69, sequence MSREDVAEMATLSLTEVDKLIN 216592000785 pantoate--beta-alanine ligase; Region: panC; TIGR00018 216592000786 Pantoate-beta-alanine ligase; Region: PanC; cd00560 216592000787 active site 216592000788 ATP-binding site [chemical binding]; other site 216592000789 pantoate-binding site; other site 216592000790 HXXH motif; other site 216592000791 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 1.6e-197 216592000792 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 216592000793 oligomerization interface [polypeptide binding]; other site 216592000794 active site 216592000795 metal binding site [ion binding]; metal-binding site 216592000796 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 1.4e-180 216592000797 Fimbrial operon 2. Present in all analysed coli genomes but with sequence divergence. 216592000798 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 216592000799 HMMPfam hit to PF00419, Fimbrial protein, score 3.7e-06 216592000800 Signal peptide predicted for EC042_0136 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.994 between residues 23 and 24 216592000801 putative fimbrial protein StaF; Provisional; Region: PRK15262 216592000802 HMMPfam hit to PF00419, Fimbrial protein, score 0.0089 216592000803 PS00061 Short-chain dehydrogenases/reductases family signature. 216592000804 1 probable transmembrane helix predicted for EC042_0137 by TMHMM2.0 at aa 7-29 216592000805 Signal peptide predicted for EC042_0137 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.968 between residues 27 and 28 216592000806 Fimbrial protein; Region: Fimbrial; cl01416 216592000807 Signal peptide predicted for EC042_0138 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 23 and 24 216592000808 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 216592000809 PapC N-terminal domain; Region: PapC_N; pfam13954 216592000810 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592000811 PapC C-terminal domain; Region: PapC_C; pfam13953 216592000812 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592000813 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592000814 putative chaperone protein EcpD; Provisional; Region: PRK09926 216592000815 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592000816 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592000817 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 4.3e-21 216592000818 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 2e-71 216592000819 PS00635 Gram-negative pili assembly chaperone signature. 216592000820 Signal peptide predicted for EC042_0140 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.993 between residues 44 and 45 216592000821 Fimbrial protein; Region: Fimbrial; cl01416 216592000822 HMMPfam hit to PF00419, Fimbrial protein, score 1.1e-05 216592000823 Signal peptide predicted for EC042_0141 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 23 and 24 216592000824 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216592000825 catalytic center binding site [active] 216592000826 ATP binding site [chemical binding]; other site 216592000827 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 3.1e-77 216592000828 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 216592000829 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 216592000830 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216592000831 active site 216592000832 NTP binding site [chemical binding]; other site 216592000833 metal binding triad [ion binding]; metal-binding site 216592000834 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216592000835 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 216592000836 HMMPfam hit to PF01743, Poly A polymerase family, score 6.7e-85 216592000837 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 216592000838 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 216592000839 active site 216592000840 nucleotide binding site [chemical binding]; other site 216592000841 HIGH motif; other site 216592000842 KMSKS motif; other site 216592000843 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 7.8e-30 216592000844 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 216592000845 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 3.1e-36 216592000846 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 216592000847 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 216592000848 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 9.7e-109 216592000849 2'-5' RNA ligase; Provisional; Region: PRK15124 216592000850 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 216592000851 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 216592000852 HMMPfam hit to PF02834, 2',5' RNA ligase family, score 1.3e-15 216592000853 HMMPfam hit to PF02834, 2',5' RNA ligase family, score 7.1e-24 216592000854 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 216592000855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592000856 ATP binding site [chemical binding]; other site 216592000857 putative Mg++ binding site [ion binding]; other site 216592000858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592000859 nucleotide binding region [chemical binding]; other site 216592000860 ATP-binding site [chemical binding]; other site 216592000861 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 216592000862 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 216592000863 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 7.1e-11 216592000864 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000865 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.1e-09 216592000866 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 2.3e-06 216592000867 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216592000868 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 216592000869 Transglycosylase; Region: Transgly; pfam00912 216592000870 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216592000871 1 probable transmembrane helix predicted for EC042_0149 by TMHMM2.0 at aa 70-92 216592000872 HMMPfam hit to PF00912, Transglycosylase, score 1e-83 216592000873 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.8e-18 216592000874 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 216592000875 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592000876 N-terminal plug; other site 216592000877 ligand-binding site [chemical binding]; other site 216592000878 PS00430 TonB-dependent receptor proteins signature 1. 216592000879 Signal peptide predicted for EC042_0150 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 33 and 34 216592000880 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.2e-21 216592000881 HMMPfam hit to PF00593, TonB dependent receptor, score 4.9e-28 216592000882 PS01156 TonB-dependent receptor proteins signature 2. 216592000883 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 216592000884 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592000885 Walker A/P-loop; other site 216592000886 ATP binding site [chemical binding]; other site 216592000887 Q-loop/lid; other site 216592000888 ABC transporter signature motif; other site 216592000889 Walker B; other site 216592000890 D-loop; other site 216592000891 H-loop/switch region; other site 216592000892 HMMPfam hit to PF00005, ABC transporter, score 9.8e-62 216592000893 PS00017 ATP/GTP-binding site motif A (P-loop). 216592000894 PS00211 ABC transporters family signature. 216592000895 Signal peptide predicted for EC042_0152 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 31 and 32 216592000896 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216592000897 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216592000898 siderophore binding site; other site 216592000899 HMMPfam hit to PF01497, Periplasmic binding protein, score 1e-06 216592000900 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592000901 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592000902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592000903 ABC-ATPase subunit interface; other site 216592000904 dimer interface [polypeptide binding]; other site 216592000905 putative PBP binding regions; other site 216592000906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592000907 ABC-ATPase subunit interface; other site 216592000908 dimer interface [polypeptide binding]; other site 216592000909 putative PBP binding regions; other site 216592000910 Signal peptide predicted for EC042_0153 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.345 between residues 31 and 32 216592000911 17 probable transmembrane helices predicted for EC042_0153 by TMHMM2.0 at aa 7-29, 57-79, 92-111, 115-137, 144-166, 239-261, 273-291, 301-323, 347-369, 389-411, 424-442, 446-468, 480-499, 525-547, 568-590, 605-624 and 631-653 216592000912 HMMPfam hit to PF01032, FecCD transport family, score 1.2e-35 216592000913 HMMPfam hit to PF01032, FecCD transport family, score 1.2e-60 216592000914 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 216592000915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592000916 inhibitor-cofactor binding pocket; inhibition site 216592000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592000918 catalytic residue [active] 216592000919 HMMPfam hit to PF00202, Aminotransferase class-III, score 6e-120 216592000920 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592000921 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216592000922 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 216592000923 Cl- selectivity filter; other site 216592000924 Cl- binding residues [ion binding]; other site 216592000925 pore gating glutamate residue; other site 216592000926 dimer interface [polypeptide binding]; other site 216592000927 H+/Cl- coupling transport residue; other site 216592000928 11 probable transmembrane helices predicted for EC042_0155 by TMHMM2.0 at aa 31-53, 75-97, 124-146, 179-201, 210-232, 252-274, 287-309, 319-341, 354-376, 391-413 and 418-440 216592000929 HMMPfam hit to PF00654, Voltage gated chloride channel, score 5e-138 216592000930 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 216592000931 HMMPfam hit to PF01521, HesB-like domain, score 1.6e-58 216592000932 PS01152 Hypothetical hesB/yadR/yfhF family signature. 216592000933 hypothetical protein; Provisional; Region: PRK10578 216592000934 UPF0126 domain; Region: UPF0126; pfam03458 216592000935 UPF0126 domain; Region: UPF0126; pfam03458 216592000936 7 probable transmembrane helices predicted for EC042_0157 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-105, 115-137, 149-168 and 172-191 216592000937 HMMPfam hit to PF03458, UPF0126 domain, score 2e-35 216592000938 HMMPfam hit to PF03458, UPF0126 domain, score 3.4e-39 216592000939 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 216592000940 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 216592000941 cobalamin binding residues [chemical binding]; other site 216592000942 putative BtuC binding residues; other site 216592000943 dimer interface [polypeptide binding]; other site 216592000944 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.5e-59 216592000945 Signal peptide predicted for EC042_0158 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.901 between residues 22 and 23 216592000946 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 216592000947 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 216592000948 HMMPfam hit to PF01048, Phosphorylase family, score 4.5e-113 216592000949 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 216592000950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216592000951 Zn2+ binding site [ion binding]; other site 216592000952 Mg2+ binding site [ion binding]; other site 216592000953 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 216592000954 HMMPfam hit to PF01966, HD domain, score 1.4e-11 216592000955 serine endoprotease; Provisional; Region: PRK10942 216592000956 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216592000957 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592000958 protein binding site [polypeptide binding]; other site 216592000959 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592000960 Signal peptide predicted for EC042_0161 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 26 and 27 216592000961 HMMPfam hit to PF00089, Trypsin, score 4.6e-32 216592000962 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 6.2e-21 216592000963 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.3e-16 216592000964 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 216592000965 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 216592000966 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216592000967 HMMPfam hit to PF05651, Putative sugar diacid recognition, score 4.7e-175 216592000968 hypothetical protein; Provisional; Region: PRK13677 216592000969 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 216592000970 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 216592000971 trimer interface [polypeptide binding]; other site 216592000972 active site 216592000973 substrate binding site [chemical binding]; other site 216592000974 CoA binding site [chemical binding]; other site 216592000975 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.34 216592000976 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.9 216592000977 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.75 216592000978 PS00101 Hexapeptide-repeat containing-transferases signature. 216592000979 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 27 216592000980 PII uridylyl-transferase; Provisional; Region: PRK05007 216592000981 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216592000982 metal binding triad; other site 216592000983 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216592000984 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216592000985 Zn2+ binding site [ion binding]; other site 216592000986 Mg2+ binding site [ion binding]; other site 216592000987 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 216592000988 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 216592000989 HMMPfam hit to PF01842, ACT domain, score 1.3e-07 216592000990 HMMPfam hit to PF01842, ACT domain, score 2e-07 216592000991 HMMPfam hit to PF01966, HD domain, score 3.3e-19 216592000992 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 1.9e-13 216592000993 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216592000994 active site 216592000995 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.6e-113 216592000996 PS00680 Methionine aminopeptidase subfamily 1 signature. 216592000997 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 216592000998 rRNA interaction site [nucleotide binding]; other site 216592000999 S8 interaction site; other site 216592001000 putative laminin-1 binding site; other site 216592001001 PS00962 Ribosomal protein S2 signature 1. 216592001002 HMMPfam hit to PF00318, Ribosomal protein S2, score 4.3e-131 216592001003 PS00963 Ribosomal protein S2 signature 2. 216592001004 elongation factor Ts; Provisional; Region: tsf; PRK09377 216592001005 UBA/TS-N domain; Region: UBA; pfam00627 216592001006 Elongation factor TS; Region: EF_TS; pfam00889 216592001007 Elongation factor TS; Region: EF_TS; pfam00889 216592001008 HMMPfam hit to PF00627, UBA/TS-N domain, score 1.3e-11 216592001009 PS01126 Elongation factor Ts signature 1. 216592001010 HMMPfam hit to PF00889, Elongation factor TS, score 4.8e-112 216592001011 PS01127 Elongation factor Ts signature 2. 216592001012 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 216592001013 putative nucleotide binding site [chemical binding]; other site 216592001014 uridine monophosphate binding site [chemical binding]; other site 216592001015 homohexameric interface [polypeptide binding]; other site 216592001016 HMMPfam hit to PF00696, Amino acid kinase family, score 2.2e-63 216592001017 ribosome recycling factor; Reviewed; Region: frr; PRK00083 216592001018 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 216592001019 hinge region; other site 216592001020 HMMPfam hit to PF01765, Ribosome recycling factor, score 6.7e-101 216592001021 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 216592001022 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 216592001023 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 216592001024 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 216592001025 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 1e-270 216592001026 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001027 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 216592001028 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216592001029 catalytic residue [active] 216592001030 putative FPP diphosphate binding site; other site 216592001031 putative FPP binding hydrophobic cleft; other site 216592001032 dimer interface [polypeptide binding]; other site 216592001033 putative IPP diphosphate binding site; other site 216592001034 HMMPfam hit to PF01255, Putative undecaprenyl diphosphate syntha, score 2e-156 216592001035 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 216592001036 Signal peptide predicted for EC042_0173 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.939 between residues 29 and 30 216592001037 HMMPfam hit to PF01148, Cytidylyltransferase family, score 1.3e-84 216592001038 8 probable transmembrane helices predicted for EC042_0173 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-211, 218-240 and 260-282 216592001039 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 216592001040 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 216592001041 PS01315 Phosphatidate cytidylyltransferase signature. 216592001042 zinc metallopeptidase RseP; Provisional; Region: PRK10779 216592001043 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216592001044 active site 216592001045 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 216592001046 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 216592001047 protein binding site [polypeptide binding]; other site 216592001048 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216592001049 putative substrate binding region [chemical binding]; other site 216592001050 4 probable transmembrane helices predicted for EC042_0174 by TMHMM2.0 at aa 23-45, 113-135, 391-413 and 441-459 216592001051 HMMPfam hit to PF02163, Peptidase family M50, score 1.3e-76 216592001052 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592001053 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.9e-14 216592001054 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 216592001055 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592001056 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592001057 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592001058 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592001059 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592001060 Surface antigen; Region: Bac_surface_Ag; pfam01103 216592001061 Signal peptide predicted for EC042_0175 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 20 and 21 216592001062 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 9.9e-09 216592001063 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 4.5e-07 216592001064 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.7e-07 216592001065 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2.9e-08 216592001066 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2.8e-07 216592001067 HMMPfam hit to PF01103, Surface antigen, score 6e-83 216592001068 periplasmic chaperone; Provisional; Region: PRK10780 216592001069 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 216592001070 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 8.4e-60 216592001071 Signal peptide predicted for EC042_0176 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 216592001072 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 216592001073 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 216592001074 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 216592001075 trimer interface [polypeptide binding]; other site 216592001076 active site 216592001077 UDP-GlcNAc binding site [chemical binding]; other site 216592001078 lipid binding site [chemical binding]; lipid-binding site 216592001079 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 5.4e-52 216592001080 PS00101 Hexapeptide-repeat containing-transferases signature. 216592001081 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.041 216592001082 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0069 216592001083 PS00101 Hexapeptide-repeat containing-transferases signature. 216592001084 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.031 216592001085 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 216592001086 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.27 216592001087 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.019 216592001088 PS00101 Hexapeptide-repeat containing-transferases signature. 216592001089 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.96 216592001090 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 14 216592001091 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 216592001092 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.3e-22 216592001093 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 216592001094 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 216592001095 active site 216592001096 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0035 216592001097 PS00101 Hexapeptide-repeat containing-transferases signature. 216592001098 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.42 216592001099 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.76 216592001100 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7 216592001101 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.3 216592001102 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.8 216592001103 PS00101 Hexapeptide-repeat containing-transferases signature. 216592001104 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9.5 216592001105 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 216592001106 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 216592001107 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 6.1e-221 216592001108 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216592001109 RNA/DNA hybrid binding site [nucleotide binding]; other site 216592001110 active site 216592001111 HMMPfam hit to PF01351, Ribonuclease HII, score 5e-97 216592001112 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 216592001113 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 216592001114 putative active site [active] 216592001115 putative PHP Thumb interface [polypeptide binding]; other site 216592001116 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216592001117 generic binding surface II; other site 216592001118 generic binding surface I; other site 216592001119 HMMPfam hit to PF02231, PHP domain N-terminal region, score 5.2e-29 216592001120 HMMPfam hit to PF02811, PHP domain C-terminal region, score 5e-36 216592001121 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 0 216592001122 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 8.5e-13 216592001123 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 216592001124 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 216592001125 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 2e-102 216592001126 lysine decarboxylase LdcC; Provisional; Region: PRK15399 216592001127 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 216592001128 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 216592001129 homodimer interface [polypeptide binding]; other site 216592001130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592001131 catalytic residue [active] 216592001132 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216592001133 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 3.7e-60 216592001134 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 8.5e-282 216592001135 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 216592001136 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 5e-89 216592001137 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 216592001138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216592001139 putative metal binding site [ion binding]; other site 216592001140 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.3e-33 216592001141 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 216592001142 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 216592001143 Ligand Binding Site [chemical binding]; other site 216592001144 TilS substrate binding domain; Region: TilS; pfam09179 216592001145 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 216592001146 HMMPfam hit to PF01171, PP-loop family, score 1.9e-105 216592001147 Rho-binding antiterminator; Provisional; Region: PRK11625 216592001148 HMMPfam hit to PF07073, Modulator of Rho-dependent transcription ter, score 6.4e-45 216592001149 hypothetical protein; Provisional; Region: PRK04964 216592001150 HMMPfam hit to PF06786, Uncharacterised protein family (UPF0253), score 1.1e-40 216592001151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 216592001152 HMMPfam hit to PF07152, YaeQ protein, score 2.8e-124 216592001153 hypothetical protein; Provisional; Region: PRK09256 216592001154 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 216592001155 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 2.1e-39 216592001156 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216592001157 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 216592001158 NlpE N-terminal domain; Region: NlpE; pfam04170 216592001159 Signal peptide predicted for EC042_0191 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.707 between residues 35 and 36 216592001160 HMMPfam hit to PF04170, Uncharacterized lipoprotein NlpE involved in, score 4.4e-160 216592001161 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001162 PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. 216592001163 hypothetical protein; Provisional; Region: PRK11479 216592001164 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 216592001165 Signal peptide predicted for EC042_0192 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.268 between residues 31 and 32 216592001166 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001167 prolyl-tRNA synthetase; Provisional; Region: PRK09194 216592001168 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 216592001169 dimer interface [polypeptide binding]; other site 216592001170 motif 1; other site 216592001171 active site 216592001172 motif 2; other site 216592001173 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 216592001174 putative deacylase active site [active] 216592001175 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216592001176 active site 216592001177 motif 3; other site 216592001178 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 216592001179 anticodon binding site; other site 216592001180 HMMPfam hit to PF03129, Anticodon binding domain, score 8.3e-28 216592001181 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 2e-08 216592001182 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1.2e-60 216592001183 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592001184 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 216592001185 homodimer interaction site [polypeptide binding]; other site 216592001186 cofactor binding site; other site 216592001187 HMMPfam hit to PF01980, Uncharacterised protein family UPF0066, score 1.8e-55 216592001188 PS01318 Uncharacterized protein family UPF0066 signature. 216592001189 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 216592001190 Signal peptide predicted for EC042_0195 by SignalP 2.0 HMM (Signal peptide probability 0.938) with cleavage site probability 0.465 between residues 21 and 22 216592001191 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001192 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 216592001193 lipoprotein, YaeC family; Region: TIGR00363 216592001194 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.5e-149 216592001195 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001196 Signal peptide predicted for EC042_0196 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.735 between residues 22 and 23 216592001197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592001198 dimer interface [polypeptide binding]; other site 216592001199 conserved gate region; other site 216592001200 ABC-ATPase subunit interface; other site 216592001201 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-21 216592001202 5 probable transmembrane helices predicted for EC042_0197 by TMHMM2.0 at aa 18-40, 60-78, 82-104, 144-166 and 181-203 216592001203 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592001204 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 216592001205 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 216592001206 Walker A/P-loop; other site 216592001207 ATP binding site [chemical binding]; other site 216592001208 Q-loop/lid; other site 216592001209 ABC transporter signature motif; other site 216592001210 Walker B; other site 216592001211 D-loop; other site 216592001212 H-loop/switch region; other site 216592001213 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 216592001214 HMMPfam hit to PF00005, ABC transporter, score 3.8e-76 216592001215 PS00211 ABC transporters family signature. 216592001216 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001217 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 216592001218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592001219 active site 216592001220 motif I; other site 216592001221 motif II; other site 216592001222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592001223 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592001224 active site 216592001225 catalytic tetrad [active] 216592001226 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.5e-86 216592001227 PS00798 Aldo/keto reductase family signature 1. 216592001228 PS00062 Aldo/keto reductase family signature 2. 216592001229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592001230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001231 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 216592001232 putative effector binding pocket; other site 216592001233 dimerization interface [polypeptide binding]; other site 216592001234 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.7e-50 216592001235 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-19 216592001236 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001237 Predicted helix-turn-helix motif with score 1503.000, SD 4.31 at aa 18-39, sequence GSFSRAAEQLGQANSAVSRAVK 216592001238 hypothetical protein; Provisional; Region: PRK05421 216592001239 putative catalytic site [active] 216592001240 putative metal binding site [ion binding]; other site 216592001241 putative phosphate binding site [ion binding]; other site 216592001242 putative catalytic site [active] 216592001243 putative phosphate binding site [ion binding]; other site 216592001244 putative metal binding site [ion binding]; other site 216592001245 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 1.4e-20 216592001246 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216592001247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592001248 S-adenosylmethionine binding site [chemical binding]; other site 216592001249 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 5.7e-06 216592001250 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 216592001251 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592001252 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592001253 catalytic residue [active] 216592001254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592001255 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592001256 HMMPfam hit to PF01476, LysM domain, score 7.2e-14 216592001257 HMMPfam hit to PF01476, LysM domain, score 4.5e-18 216592001258 Predicted helix-turn-helix motif with score 1185.000, SD 3.22 at aa 349-370, sequence DTLSSIASRLGVSTKDLQQWNK 216592001259 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 3.7e-39 216592001260 PS00922 Prokaryotic transglycosylases signature. 216592001261 HMMPfam hit to PF06474, MLTD_N, score 5.1e-40 216592001262 Signal peptide predicted for EC042_0204 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.364 between residues 26 and 27 216592001263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001264 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 216592001265 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1e-37 216592001266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592001267 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 216592001268 RNA/DNA hybrid binding site [nucleotide binding]; other site 216592001269 active site 216592001270 HMMPfam hit to PF00075, RNase H, score 8.3e-72 216592001271 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 216592001272 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 216592001273 active site 216592001274 catalytic site [active] 216592001275 substrate binding site [chemical binding]; other site 216592001276 HMMPfam hit to PF00929, Exonuclease, score 5.2e-53 216592001277 Signal peptide predicted for EC042_0209 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.464 between residues 22 and 23 216592001278 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001279 type VI secretion system 1. Sequence divergence between 0157 and Uropathogenic strains. 216592001280 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 216592001281 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 1.2e-62 216592001282 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 216592001283 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592001284 ImpA domain protein; Region: DUF3702; pfam12486 216592001285 HMMPfam hit to PF06812, ImpA-related N-terminal, score 3.8e-23 216592001286 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 216592001287 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 216592001288 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 216592001289 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 1.6e-48 216592001290 HMMPfam hit to PF06761, ImcF-related, score 2.7e-122 216592001291 3 probable transmembrane helices predicted for EC042_0212 by TMHMM2.0 at aa 24-46, 61-83 and 452-474 216592001292 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001293 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592001294 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 216592001295 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 216592001296 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 216592001297 Signal peptide predicted for EC042_0214 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.397 between residues 39 and 40 216592001298 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 216592001299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592001300 Walker A motif; other site 216592001301 ATP binding site [chemical binding]; other site 216592001302 Walker B motif; other site 216592001303 arginine finger; other site 216592001304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592001305 Walker A motif; other site 216592001306 ATP binding site [chemical binding]; other site 216592001307 Walker B motif; other site 216592001308 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216592001309 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 3.9e-81 216592001310 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001311 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.5e-05 216592001312 PS00870 Chaperonins clpA/B signature 1. 216592001313 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001314 HMMPfam hit to PF02861, Clp amino terminal domain, score 0.024 216592001315 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 216592001316 1 probable transmembrane helix predicted for EC042_0216 by TMHMM2.0 at aa 217-239 216592001317 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 216592001318 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 216592001319 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 4.8e-195 216592001320 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 216592001321 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001322 Signal peptide predicted for EC042_0218 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.461 between residues 18 and 19 216592001323 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 216592001324 FHA domain; Region: FHA; pfam00498 216592001325 phosphopeptide binding site; other site 216592001326 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 216592001327 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 6.3e-119 216592001328 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 216592001329 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 216592001330 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 2.3e-197 216592001331 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 216592001332 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 4.9e-33 216592001333 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 216592001334 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216592001335 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 2.9e-285 216592001336 Protein of unknown function (DUF770); Region: DUF770; pfam05591 216592001337 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 4e-50 216592001338 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 216592001339 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 3.3e-84 216592001340 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216592001341 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216592001342 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 216592001343 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 216592001344 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 216592001345 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 4.6e-56 216592001346 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 216592001347 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 216592001348 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216592001349 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592001350 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592001351 HMMPfam hit to PF01609, Transposase DDE domain, score 7.9e-35 216592001352 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 216592001353 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 216592001354 putative active site [active] 216592001355 putative NTP binding site [chemical binding]; other site 216592001356 putative nucleic acid binding site [nucleotide binding]; other site 216592001357 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 216592001358 HMMPfam hit to PF00078, Reverse transcriptase (RNA-dependent DNA pol, score 1.4e-55 216592001359 Predicted helix-turn-helix motif with score 1055.000, SD 2.78 at aa 321-342, sequence IKATGIRKRVDLSIEQIAKWIN 216592001360 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 216592001361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216592001362 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592001363 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592001364 HMMPfam hit to PF01609, Transposase DDE domain, score 7.4e-48 216592001365 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 216592001366 Signal peptide predicted for EC042_0235 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.965 between residues 27 and 28 216592001367 1 probable transmembrane helix predicted for EC042_0235 by TMHMM2.0 at aa 12-31 216592001369 C-N hydrolase family amidase; Provisional; Region: PRK10438 216592001370 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 216592001371 putative active site [active] 216592001372 catalytic triad [active] 216592001373 dimer interface [polypeptide binding]; other site 216592001374 multimer interface [polypeptide binding]; other site 216592001375 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 6.9e-10 216592001376 C-lysozyme inhibitor; Provisional; Region: PRK09993 216592001377 Signal peptide predicted for EC042_0237 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 216592001378 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001379 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 216592001380 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216592001381 active site 216592001382 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 216592001383 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 5e-23 216592001384 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 4.2e-05 216592001385 2 probable transmembrane helices predicted for EC042_0238 by TMHMM2.0 at aa 23-45 and 50-72 216592001386 Signal peptide predicted for EC042_0238 by SignalP 2.0 HMM (Signal peptide probability 0.814) with cleavage site probability 0.316 between residues 58 and 59 216592001387 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 216592001388 dimer interface [polypeptide binding]; other site 216592001389 active site 216592001390 HMMPfam hit to PF01380, SIS domain, score 5.6e-28 216592001391 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 216592001392 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 216592001393 putative active site [active] 216592001394 putative dimer interface [polypeptide binding]; other site 216592001395 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 7.6e-63 216592001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 216592001397 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592001398 HMMPfam hit to PF06104, Bacterial protein of unknown function (DUF94, score 6.5e-159 216592001399 1 probable transmembrane helix predicted for EC042_0241 by TMHMM2.0 at aa 4-26 216592001400 Signal peptide predicted for EC042_0241 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.618 between residues 19 and 20 216592001401 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592001402 NlpC/P60 family; Region: NLPC_P60; pfam00877 216592001403 Signal peptide predicted for EC042_0242 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.406 between residues 40 and 41 216592001404 1 probable transmembrane helix predicted for EC042_0242 by TMHMM2.0 at aa 15-37 216592001405 HMMPfam hit to PF00877, NlpC/P60 family, score 7.2e-54 216592001406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 216592001407 HMMPfam hit to PF07605, Protein of unknown function (DUF1568), score 0.00043 216592001408 Flag-2 locus. Unique to 042 216592001409 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 216592001410 FHIPEP family; Region: FHIPEP; pfam00771 216592001411 HMMPfam hit to PF00771, FHIPEP family, score 1.8e-272 216592001412 7 probable transmembrane helices predicted for EC042_0245 by TMHMM2.0 at aa 9-31, 36-58, 71-93, 113-135, 208-230, 245-267 and 280-302 216592001413 PS00994 Bacterial export FHIPEP family signature. 216592001414 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 216592001415 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 216592001416 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 3.2e-97 216592001417 4 probable transmembrane helices predicted for EC042_0246 by TMHMM2.0 at aa 35-54, 93-115, 153-175 and 195-214 216592001418 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 216592001419 HMMPfam hit to PF01311, Bacterial export proteins, family, score 1.2e-35 216592001420 6 probable transmembrane helices predicted for EC042_0247 by TMHMM2.0 at aa 10-32, 44-63, 78-100, 129-151, 171-204 and 211-233 216592001421 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 216592001422 HMMPfam hit to PF01313, Bacterial export proteins, family, score 9.3e-12 216592001423 2 probable transmembrane helices predicted for EC042_0248 by TMHMM2.0 at aa 17-39 and 52-74 216592001424 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 216592001425 4 probable transmembrane helices predicted for EC042_0249 by TMHMM2.0 at aa 7-29, 49-71, 190-212 and 227-249 216592001426 HMMPfam hit to PF00813, FliP family, score 3.1e-92 216592001427 PS01061 Flagella transport protein fliP family signature 2. 216592001428 PS01060 Flagella transport protein fliP family signature 1. 216592001429 PS00041 Bacterial regulatory proteins, araC family signature. 216592001430 Signal peptide predicted for EC042_0249 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 216592001431 flagellar motor switch protein FliN; Region: fliN; TIGR02480 216592001432 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 3.9e-17 216592001433 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 216592001434 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.046 216592001435 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 216592001436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592001437 Walker A motif; other site 216592001438 ATP binding site [chemical binding]; other site 216592001439 Walker B motif; other site 216592001440 arginine finger; other site 216592001441 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592001442 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 4.5e-90 216592001443 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592001444 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592001445 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592001446 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592001447 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 3.9e-07 216592001448 Predicted helix-turn-helix motif with score 1891.000, SD 5.63 at aa 294-315, sequence GNRSKIADLLGITPRALRYRLA 216592001449 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 216592001450 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 2.2e-09 216592001451 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 216592001452 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 216592001453 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 216592001454 Signal peptide predicted for EC042_0254 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.656 between residues 36 and 37 216592001455 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 1.6e-55 216592001456 2 probable transmembrane helices predicted for EC042_0254 by TMHMM2.0 at aa 25-47 and 436-458 216592001457 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 216592001458 MgtE intracellular N domain; Region: MgtE_N; smart00924 216592001459 FliG C-terminal domain; Region: FliG_C; pfam01706 216592001460 HMMPfam hit to PF01706, FliG C-terminal domain, score 1e-11 216592001461 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 216592001462 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 216592001463 Flagellar assembly protein FliH; Region: FliH; pfam02108 216592001464 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 1.7e-07 216592001465 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 216592001466 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 216592001467 Walker A motif/ATP binding site; other site 216592001468 Walker B motif; other site 216592001469 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 1.4e-104 216592001470 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001471 PS00152 ATP synthase alpha and beta subunits signature. 216592001472 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 216592001473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216592001474 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 216592001475 active site 216592001476 nucleotide binding site [chemical binding]; other site 216592001477 HIGH motif; other site 216592001478 KMSKS motif; other site 216592001479 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.3e-13 216592001480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216592001481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216592001482 active site 216592001483 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 216592001484 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001485 HMMPfam hit to PF00535, Glycosyl transferase, score 1.3e-13 216592001486 FlgN protein; Region: FlgN; pfam05130 216592001487 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 216592001488 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 1.1e-07 216592001489 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 216592001490 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 216592001491 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 216592001492 HMMPfam hit to PF03240, FlgA family, score 3.5e-26 216592001493 Signal peptide predicted for EC042_0264 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.830 between residues 24 and 25 216592001494 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 216592001495 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 216592001496 PS00588 Flagella basal body rod proteins signature. 216592001498 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.00018 216592001499 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 216592001500 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 216592001501 HMMPfam hit to PF03963, Flagellar hook capping protein, score 0.00037 216592001502 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 216592001503 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592001504 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 216592001505 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592001506 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.3e-06 216592001507 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 2.3e-22 216592001508 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 3.1e-15 216592001509 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 216592001510 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592001511 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592001512 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.1e-07 216592001513 PS00588 Flagella basal body rod proteins signature. 216592001514 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 216592001515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592001516 PS00588 Flagella basal body rod proteins signature. 216592001517 HMMPfam hit to PF00460, Flagella basal body rod protein, score 3.8e-13 216592001518 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 216592001519 Flagellar L-ring protein; Region: FlgH; pfam02107 216592001520 Signal peptide predicted for EC042_0271 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.464 between residues 21 and 22 216592001521 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592001522 HMMPfam hit to PF02107, Flagellar L-ring protein, score 2e-45 216592001523 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 216592001524 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 216592001525 Signal peptide predicted for EC042_0272 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 27 and 28 216592001526 HMMPfam hit to PF02119, Flagellar P-ring protein, score 2.6e-165 216592001527 Rod binding protein; Region: Rod-binding; cl01626 216592001528 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 216592001529 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592001530 HMMPfam hit to PF00460, Flagella basal body rod protein, score 8.7e-05 216592001531 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 5.4e-15 216592001532 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 216592001533 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216592001534 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.3e-05 216592001535 Signal peptide predicted for EC042_0276 by SignalP 2.0 HMM (Signal peptide probability 0.970) with cleavage site probability 0.352 between residues 17 and 18 216592001536 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216592001537 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 216592001538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592001539 non-specific DNA binding site [nucleotide binding]; other site 216592001540 salt bridge; other site 216592001541 sequence-specific DNA binding site [nucleotide binding]; other site 216592001542 HMMPfam hit to PF01381, Helix-turn-helix, score 7.4e-12 216592001543 Predicted helix-turn-helix motif with score 1667.000, SD 4.86 at aa 41-62, sequence ISQTEMAAAMGIKQPTLAKMEQ 216592001544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216592001545 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 216592001546 DNA binding site [nucleotide binding] 216592001547 1 probable transmembrane helix predicted for EC042_0279 by TMHMM2.0 at aa 143-165 216592001548 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 9.4e-10 216592001549 flagellin; Reviewed; Region: PRK08869 216592001550 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216592001551 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216592001552 Signal peptide predicted for EC042_0280 by SignalP 2.0 HMM (Signal peptide probability 0.826) with cleavage site probability 0.532 between residues 25 and 26 216592001553 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 9.1e-39 216592001554 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 3e-21 216592001555 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 216592001556 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 216592001557 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 5.2e-15 216592001558 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 1.4e-50 216592001559 Flagellar protein FliS; Region: FliS; cl00654 216592001560 HMMPfam hit to PF02561, Flagellar protein FliS, score 2e-20 216592001561 adenylate kinase; Region: PLN02674 216592001562 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 216592001563 Signal peptide predicted for EC042_0284 by SignalP 2.0 HMM (Signal peptide probability 0.887) with cleavage site probability 0.749 between residues 20 and 21 216592001564 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 2.2e-10 216592001565 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 216592001566 Signal peptide predicted for EC042_0285 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.513 between residues 22 and 23 216592001567 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 0.00022 216592001568 1 probable transmembrane helix predicted for EC042_0285 by TMHMM2.0 at aa 5-27 216592001569 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 216592001570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592001571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592001572 DNA binding residues [nucleotide binding] 216592001573 HMMPfam hit to PF04542, Sigma-70 region, score 3.9e-11 216592001574 HMMPfam hit to PF04545, Sigma-70, region, score 2.2e-12 216592001575 Predicted helix-turn-helix motif with score 1519.000, SD 4.36 at aa 204-225, sequence MNLKEIALVLGLTEARICQLNK 216592001576 flagellar motor protein MotA; Provisional; Region: PRK12482 216592001577 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 216592001578 Signal peptide predicted for EC042_0287 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.683 between residues 21 and 22 216592001579 4 probable transmembrane helices predicted for EC042_0287 by TMHMM2.0 at aa 7-29, 34-53, 172-191 and 195-217 216592001580 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 0.00078 216592001581 PS01307 Flagellar motor protein motA family signature. 216592001582 hypothetical protein; Validated; Region: PRK06778 216592001583 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 216592001584 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592001585 ligand binding site [chemical binding]; other site 216592001586 1 probable transmembrane helix predicted for EC042_0288 by TMHMM2.0 at aa 32-54 216592001587 HMMPfam hit to PF00691, OmpA family, score 1.3e-19 216592001588 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216592001589 active site 216592001590 DNA polymerase IV; Validated; Region: PRK02406 216592001591 DNA binding site [nucleotide binding] 216592001592 HMMPfam hit to PF00817, impB/mucB/samB family, score 3.3e-144 216592001593 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 216592001594 HMMPfam hit to PF02604, Phd_YefM, score 5.4e-12 216592001596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216592001597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592001598 Coenzyme A binding pocket [chemical binding]; other site 216592001599 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.8e-09 216592001600 hypothetical protein; Reviewed; Region: PRK09588 216592001601 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 216592001602 HMMPfam hit to PF01139, Uncharacterized protein family UPF0027, score 9.8e-104 216592001603 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 216592001604 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 216592001605 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1.6e-41 216592001606 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216592001607 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 216592001608 5 probable transmembrane helices predicted for EC042_0296 by TMHMM2.0 at aa 15-34, 47-69, 79-101, 108-133 and 153-175 216592001609 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 216592001610 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 216592001611 metal binding site [ion binding]; metal-binding site 216592001612 dimer interface [polypeptide binding]; other site 216592001613 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3e-16 216592001614 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592001615 active site 216592001616 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 7.6e-19 216592001617 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592001618 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 216592001619 HMMPfam hit to PF06500, Protein of unknown function (DUF1100), score 0 216592001620 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 216592001621 HMMPfam hit to PF07417, Transcriptional regulator Crl, score 1.2e-97 216592001622 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592001623 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592001624 trimer interface [polypeptide binding]; other site 216592001625 eyelet of channel; other site 216592001626 HMMPfam hit to PF00267, Gram-negative porin, score 5.9e-202 216592001627 PS00576 General diffusion Gram-negative porins signature. 216592001628 Signal peptide predicted for EC042_0302 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 216592001629 gamma-glutamyl kinase; Provisional; Region: PRK05429 216592001630 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 216592001631 nucleotide binding site [chemical binding]; other site 216592001632 homotetrameric interface [polypeptide binding]; other site 216592001633 putative phosphate binding site [ion binding]; other site 216592001634 putative allosteric binding site; other site 216592001635 PUA domain; Region: PUA; pfam01472 216592001636 HMMPfam hit to PF00696, Amino acid kinase family, score 1e-58 216592001637 PS00902 Glutamate 5-kinase signature. 216592001638 HMMPfam hit to PF01472, PUA domain, score 3.8e-30 216592001639 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 216592001640 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 216592001641 putative catalytic cysteine [active] 216592001642 PS01223 Gamma-glutamyl phosphate reductase signature. 216592001643 Sequence divergence between 0157 and Uropathogenic strains, 0157 contains cryptic prophage CP-933, next to tRNA 216592001645 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 216592001646 putative active site [active] 216592001647 putative NTP binding site [chemical binding]; other site 216592001648 putative nucleic acid binding site [nucleotide binding]; other site 216592001649 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 216592001650 active site 216592001651 catalytic triad [active] 216592001652 dimer interface [polypeptide binding]; other site 216592001653 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001654 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 216592001655 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 216592001656 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 216592001657 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 216592001658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592001659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001660 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216592001661 putative effector binding pocket; other site 216592001662 putative dimerization interface [polypeptide binding]; other site 216592001663 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.7e-38 216592001664 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-22 216592001665 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001666 Predicted helix-turn-helix motif with score 1540.000, SD 4.43 at aa 20-41, sequence GSFTAAAQRLGLAQSGVSRSVR 216592001667 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216592001668 Signal peptide predicted for EC042_0311 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 30 and 31 216592001669 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216592001670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592001671 putative substrate translocation pore; other site 216592001672 12 probable transmembrane helices predicted for EC042_0312 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 110-132, 144-166, 171-193, 216-238, 253-275, 280-302, 307-329, 341-363 and 368-390 216592001673 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-40 216592001674 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216592001675 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216592001676 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216592001677 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216592001678 HMMPfam hit to PF02625, XdhC and CoxI family, score 3.6e-28 216592001679 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216592001680 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 216592001681 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216592001682 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydroge, score 1.1e-199 216592001683 Predicted helix-turn-helix motif with score 1091.000, SD 2.90 at aa 215-236, sequence WCRTDLAKTLKVPVENVRIISP 216592001684 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydroge, score 5.9e-34 216592001685 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216592001686 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216592001687 HMMPfam hit to PF00941, FAD binding domain in molybdopterin deh, score 2.5e-05 216592001688 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 216592001689 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592001690 catalytic loop [active] 216592001691 iron binding site [ion binding]; other site 216592001692 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216592001693 HMMPfam hit to PF01799, [2Fe-2S] binding domain, score 3.6e-46 216592001694 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 2e-13 216592001695 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216592001696 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 216592001697 Signal peptide predicted for EC042_0317 by SignalP 2.0 HMM (Signal peptide probability 0.924) with cleavage site probability 0.364 between residues 29 and 30 216592001698 3 probable transmembrane helices predicted for EC042_0317 by TMHMM2.0 at aa 13-35, 98-120 and 132-154 216592001699 HMMPfam hit to PF07274, Protein of unknown function (DUF1440), score 1.1e-114 216592001700 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 216592001701 Fimbrial operon 3 216592001702 1 probable transmembrane helix predicted for EC042_0318 by TMHMM2.0 at aa 21-43 216592001703 Signal peptide predicted for EC042_0318 by SignalP 2.0 HMM (Signal peptide probability 0.898) with cleavage site probability 0.738 between residues 27 and 28 216592001704 Signal peptide predicted for EC042_0319 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.430 between residues 22 and 23 216592001705 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592001706 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 216592001707 PS00445 FGGY family of carbohydrate kinases signature 2. 216592001708 Signal peptide predicted for EC042_0320 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.849 between residues 29 and 30 216592001709 putative fimbrial protein TcfA; Provisional; Region: PRK15308 216592001710 Signal peptide predicted for EC042_0321 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 20 and 21 216592001711 Signal peptide predicted for EC042_0322 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 216592001712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592001713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592001714 DNA binding residues [nucleotide binding] 216592001715 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 8.3e-07 216592001716 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 216592001717 HMMPfam hit to PF00444, Ribosomal protein L36, score 1.6e-05 216592001718 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 216592001719 HMMPfam hit to PF01197, Ribosomal protein L31, score 1.8e-14 216592001720 ROD 216592001721 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216592001722 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 216592001723 putative active site [active] 216592001724 putative FMN binding site [chemical binding]; other site 216592001725 putative substrate binding site [chemical binding]; other site 216592001726 putative catalytic residue [active] 216592001727 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1.6e-84 216592001728 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216592001729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592001730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001731 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216592001732 putative effector binding pocket; other site 216592001733 putative dimerization interface [polypeptide binding]; other site 216592001734 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-17 216592001735 Predicted helix-turn-helix motif with score 1481.000, SD 4.23 at aa 43-64, sequence GSFSRAASEMGITRAALSQNLK 216592001736 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001737 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-35 216592001738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592001739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001740 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216592001741 putative effector binding pocket; other site 216592001742 putative dimerization interface [polypeptide binding]; other site 216592001743 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.9e-23 216592001744 Predicted helix-turn-helix motif with score 1908.000, SD 5.69 at aa 33-54, sequence RSFTKAAGKLGVSQSALSHAMK 216592001745 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001746 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.1e-45 216592001747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592001748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592001749 active site 216592001750 catalytic tetrad [active] 216592001751 HMMPfam hit to PF00248, Aldo/keto reductase family, score 4.7e-70 216592001752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592001753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592001754 active site 216592001755 catalytic tetrad [active] 216592001756 HMMPfam hit to PF00248, Aldo/keto reductase family, score 7.1e-110 216592001757 PS00063 Aldo/keto reductase family putative active site signature. 216592001758 PS00062 Aldo/keto reductase family signature 2. 216592001759 PS00798 Aldo/keto reductase family signature 1. 216592001760 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 216592001761 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592001762 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592001763 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592001764 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592001765 Signal peptide predicted for EC042_0333 by SignalP 2.0 HMM (Signal peptide probability 0.795) with cleavage site probability 0.672 between residues 44 and 45 216592001766 1 probable transmembrane helix predicted for EC042_0333 by TMHMM2.0 at aa 21-43 216592001767 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001768 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 9.5e-05 216592001769 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 8e-08 216592001770 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.8e-13 216592001771 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 6.9e-08 216592001772 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 216592001773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592001774 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 216592001775 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 4.1e-25 216592001776 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1.2e-11 216592001777 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 2.5e-06 216592001778 Predicted helix-turn-helix motif with score 1482.000, SD 4.23 at aa 33-54, sequence ISIEDIAQKSGYSRRNIQLLFR 216592001779 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592001780 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592001781 active site 216592001782 catalytic tetrad [active] 216592001783 HMMPfam hit to PF00248, Aldo/keto reductase family, score 4.1e-99 216592001784 PS00798 Aldo/keto reductase family signature 1. 216592001785 PS00062 Aldo/keto reductase family signature 2. 216592001786 PS00063 Aldo/keto reductase family putative active site signature. 216592001787 Predicted membrane protein [Function unknown]; Region: COG3059 216592001788 HMMPfam hit to PF04224, Protein of unknown function, DUF417, score 3.2e-123 216592001789 3 probable transmembrane helices predicted for EC042_0336 by TMHMM2.0 at aa 16-38, 86-105 and 112-134 216592001790 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592001791 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 6.7e-05 216592001792 Signal peptide predicted for EC042_0337 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23 216592001793 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 216592001794 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216592001795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592001796 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216592001797 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.1e-39 216592001798 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 2.8e-79 216592001799 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216592001800 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001801 Cupin; Region: Cupin_6; pfam12852 216592001802 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216592001803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592001804 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00011 216592001805 Predicted helix-turn-helix motif with score 1090.000, SD 2.90 at aa 194-215, sequence WTVESLASIAHMSRASFAQLFR 216592001806 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.8e-07 216592001807 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216592001808 Cysteine-rich domain; Region: CCG; pfam02754 216592001809 Cysteine-rich domain; Region: CCG; pfam02754 216592001810 HMMPfam hit to PF02754, Cysteine-rich domain, score 1.3e-14 216592001811 HMMPfam hit to PF02754, Cysteine-rich domain, score 2.8e-16 216592001812 iron-sulfur cluster-binding protein; Region: TIGR00273 216592001813 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 216592001814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592001815 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 216592001816 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.012 216592001817 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592001818 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.015 216592001819 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592001820 Uncharacterized conserved protein [Function unknown]; Region: COG1556 216592001821 HMMPfam hit to PF02589, Uncharacterized ACR, YkgG family COG1556, score 2.4e-89 216592001822 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 216592001823 2 probable transmembrane helices predicted for EC042_0343 by TMHMM2.0 at aa 42-61 and 204-226 216592001824 choline dehydrogenase; Validated; Region: PRK02106 216592001825 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216592001826 HMMPfam hit to PF05199, GMC oxidoreductase, score 7.6e-113 216592001827 HMMPfam hit to PF00732, GMC oxidoreductase, score 1.2e-179 216592001828 PS00624 GMC oxidoreductases signature 2. 216592001829 PS00623 GMC oxidoreductases signature 1. 216592001830 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 216592001831 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 216592001832 tetrameric interface [polypeptide binding]; other site 216592001833 NAD binding site [chemical binding]; other site 216592001834 catalytic residues [active] 216592001835 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.1e-274 216592001836 PS00070 Aldehyde dehydrogenases cysteine active site. 216592001837 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592001838 transcriptional regulator BetI; Validated; Region: PRK00767 216592001839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592001840 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 216592001841 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.7e-15 216592001842 PS01081 Bacterial regulatory proteins, tetR family signature. 216592001843 Predicted helix-turn-helix motif with score 1906.000, SD 5.68 at aa 30-51, sequence ATIAQIARRAGVSTGIISHYFR 216592001844 choline transport protein BetT; Provisional; Region: PRK09928 216592001845 12 probable transmembrane helices predicted for EC042_0347 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 143-165, 194-216, 231-253, 265-287, 319-338, 350-369, 400-422, 452-474 and 478-497 216592001846 HMMPfam hit to PF02028, BCCT family transporter, score 0 216592001847 PS01303 BCCT family of transporters signature. 216592001848 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592001849 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592001850 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592001851 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592001852 Present in 0157, absent in Uropathogenic, Haemagluttinin repeat autotransporter protein 216592001853 HMMPfam hit to PF05594, no description, score 3.5 216592001854 HMMPfam hit to PF05594, no description, score 8.2 216592001855 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216592001856 HMMPfam hit to PF05594, no description, score 4.2 216592001857 HMMPfam hit to PF05594, no description, score 8.6 216592001858 HMMPfam hit to PF03212, Pertactin, score 0.0036 216592001859 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.9e-45 216592001860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592001861 DNA binding residues [nucleotide binding] 216592001862 dimerization interface [polypeptide binding]; other site 216592001863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592001864 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.5e-05 216592001865 Predicted helix-turn-helix motif with score 1028.000, SD 2.69 at aa 43-64, sequence MSVTEISQYRNRSAKTISHQKK 216592001866 HMMPfam hit to PF00563, EAL domain, score 1e-108 216592001867 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 216592001868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592001870 dimerization interface [polypeptide binding]; other site 216592001871 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-18 216592001872 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.7e-16 216592001873 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001874 Predicted helix-turn-helix motif with score 1931.000, SD 5.76 at aa 20-41, sequence GSFSKAAEELGLTTSAISYTIK 216592001875 Signal peptide predicted for EC042_0350 by SignalP 2.0 HMM (Signal peptide probability 0.742) with cleavage site probability 0.493 between residues 25 and 26 216592001876 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 216592001877 HMMPfam hit to PF06496, Protein of unknown function (DUF1097), score 4.2e-89 216592001878 4 probable transmembrane helices predicted for EC042_0351 by TMHMM2.0 at aa 29-51, 58-80, 85-104 and 109-131 216592001879 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216592001880 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 216592001881 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216592001882 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216592001883 HMMPfam hit to PF00023, Ankyrin repeat, score 2.2e-06 216592001884 HMMPfam hit to PF00023, Ankyrin repeat, score 11 216592001885 HMMPfam hit to PF00023, Ankyrin repeat, score 2 216592001886 HMMPfam hit to PF00023, Ankyrin repeat, score 2.3e-05 216592001887 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 216592001888 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 216592001889 CoA binding domain; Region: CoA_binding; pfam02629 216592001890 CoA-ligase; Region: Ligase_CoA; pfam00549 216592001891 HMMPfam hit to PF06263, Bacterial FdrA protein, score 2.3e-69 216592001892 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 216592001893 HMMPfam hit to PF06545, Protein of unknown function (DUF1116), score 0 216592001894 Signal peptide predicted for EC042_0357 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.770 between residues 29 and 30 216592001895 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 216592001896 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 216592001897 putative substrate binding site [chemical binding]; other site 216592001898 nucleotide binding site [chemical binding]; other site 216592001899 nucleotide binding site [chemical binding]; other site 216592001900 homodimer interface [polypeptide binding]; other site 216592001901 HMMPfam hit to PF00696, Amino acid kinase family, score 1.5e-89 216592001902 putative deaminase; Validated; Region: PRK06846 216592001903 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 216592001904 active site 216592001905 Signal peptide predicted for EC042_0359 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.976 between residues 33 and 34 216592001906 Signal peptide predicted for EC042_0360 by SignalP 2.0 HMM (Signal peptide probability 0.967) with cleavage site probability 0.567 between residues 17 and 18 216592001907 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216592001908 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216592001909 putative NAD(P) binding site [chemical binding]; other site 216592001910 putative substrate binding site [chemical binding]; other site 216592001911 catalytic Zn binding site [ion binding]; other site 216592001912 structural Zn binding site [ion binding]; other site 216592001913 dimer interface [polypeptide binding]; other site 216592001914 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 9.3e-110 216592001915 PS00190 Cytochrome c family heme-binding site signature. 216592001916 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592001917 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216592001918 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 216592001919 6 probable transmembrane helices predicted for EC042_0364 by TMHMM2.0 at aa 20-42, 54-76, 86-103, 136-153, 163-180 and 199-221 216592001920 HMMPfam hit to PF01810, LysE type translocator, score 8.1e-72 216592001921 hypothetical protein; Provisional; Region: PRK09929 216592001922 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.3e-13 216592001923 Signal peptide predicted for EC042_0365 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22 216592001924 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 216592001925 Propionate catabolism activator; Region: PrpR_N; pfam06506 216592001926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592001927 Walker A motif; other site 216592001928 ATP binding site [chemical binding]; other site 216592001929 Walker B motif; other site 216592001930 arginine finger; other site 216592001931 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592001932 Predicted helix-turn-helix motif with score 1255.000, SD 3.46 at aa 506-527, sequence GDKTAAANYLGISRTTFWRRLK 216592001933 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592001934 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 4e-130 216592001935 PS00134 Serine proteases, trypsin family, histidine active site. 216592001936 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592001937 HMMPfam hit to PF06506, Propionate catabolism activator, score 8.2e-94 216592001938 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216592001939 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 216592001940 tetramer interface [polypeptide binding]; other site 216592001941 active site 216592001942 Mg2+/Mn2+ binding site [ion binding]; other site 216592001943 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 216592001944 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 216592001945 dimer interface [polypeptide binding]; other site 216592001946 active site 216592001947 citrylCoA binding site [chemical binding]; other site 216592001948 oxalacetate/citrate binding site [chemical binding]; other site 216592001949 coenzyme A binding site [chemical binding]; other site 216592001950 catalytic triad [active] 216592001951 HMMPfam hit to PF00285, Citrate synthase, score 2.2e-102 216592001952 PS00017 ATP/GTP-binding site motif A (P-loop). 216592001953 PS00480 Citrate synthase signature. 216592001954 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 216592001955 2-methylcitrate dehydratase; Region: prpD; TIGR02330 216592001956 HMMPfam hit to PF03972, MmgE/PrpD family, score 1.4e-249 216592001957 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592001958 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 216592001959 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 216592001960 acyl-activating enzyme (AAE) consensus motif; other site 216592001961 putative AMP binding site [chemical binding]; other site 216592001962 putative active site [active] 216592001963 putative CoA binding site [chemical binding]; other site 216592001964 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.1e-111 216592001965 PS00455 Putative AMP-binding domain signature. 216592001966 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 216592001967 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 216592001968 Na binding site [ion binding]; other site 216592001969 putative substrate binding site [chemical binding]; other site 216592001970 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 1.6e-121 216592001971 12 probable transmembrane helices predicted for EC042_0373 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 194-216, 223-245, 255-277, 289-311, 321-340, 360-379 and 383-402 216592001972 cytosine deaminase; Provisional; Region: PRK09230 216592001973 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 216592001974 active site 216592001975 HMMPfam hit to PF01979, Amidohydrolase family, score 0.077 216592001976 Present in 0157, absent in Uropathogenic, cyn operon (regulator, carbonic anhydrase, cyanase, cyanate transport) 216592001977 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 216592001978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592001979 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 216592001980 dimerization interface [polypeptide binding]; other site 216592001981 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.7e-58 216592001982 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.2e-25 216592001983 PS00044 Bacterial regulatory proteins, lysR family signature. 216592001984 Predicted helix-turn-helix motif with score 1647.000, SD 4.80 at aa 16-37, sequence GSFTRAASVLHVSQPALSQQIR 216592001985 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 216592001986 active site clefts [active] 216592001987 zinc binding site [ion binding]; other site 216592001988 dimer interface [polypeptide binding]; other site 216592001989 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.7e-94 216592001990 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 216592001991 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 216592001992 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 216592001993 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 216592001994 oligomer interface [polypeptide binding]; other site 216592001995 active site 216592001996 HMMPfam hit to PF02560, Cyanate lyase C-terminal domain, score 2e-57 216592001997 putative cyanate transporter; Provisional; Region: cynX; PRK09705 216592001998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592001999 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-28 216592002000 12 probable transmembrane helices predicted for EC042_0378 by TMHMM2.0 at aa 2-24, 34-56, 68-85, 90-112, 124-146, 156-173, 201-223, 228-250, 263-282, 287-309, 321-340 and 350-372 216592002001 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 216592002002 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 216592002003 active site 216592002004 substrate binding site [chemical binding]; other site 216592002005 trimer interface [polypeptide binding]; other site 216592002006 CoA binding site [chemical binding]; other site 216592002007 PS00101 Hexapeptide-repeat containing-transferases signature. 216592002008 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.077 216592002009 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.17 216592002010 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.14 216592002011 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 216592002012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002013 putative substrate translocation pore; other site 216592002014 HMMPfam hit to PF01306, LacY proton/sugar symporter, score 0 216592002015 11 probable transmembrane helices predicted for EC042_0380 by TMHMM2.0 at aa 13-35, 45-67, 76-98, 103-125, 145-164, 168-187, 222-239, 261-283, 304-326, 346-368 and 380-402 216592002016 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.5e-13 216592002017 PS00897 LacY family proton/sugar symporters signature 2. 216592002018 PS00896 LacY family proton/sugar symporters signature 1. 216592002019 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 216592002020 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216592002021 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216592002022 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216592002023 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 216592002024 HMMPfam hit to PF02930, Beta galactosidase small chain, C ter, score 4.3e-49 216592002025 HMMPfam hit to PF02929, Beta galactosidase small chain, N ter, score 1.6e-90 216592002026 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002027 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 718-739, sequence WHQWRLAENLSVTLPAASHSIP 216592002028 HMMPfam hit to PF02836, Glycosyl hydrolases family 2, TIM bar, score 2.7e-195 216592002029 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 216592002030 PS00719 Glycosyl hydrolases family 2 signature 1. 216592002031 HMMPfam hit to PF00703, Glycosyl hydrolases family 2, immunog, score 1.1e-55 216592002032 HMMPfam hit to PF02837, Glycosyl hydrolases family 2, sugar b, score 1e-93 216592002033 lac repressor; Reviewed; Region: lacI; PRK09526 216592002034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592002035 DNA binding site [nucleotide binding] 216592002036 domain linker motif; other site 216592002037 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 216592002038 ligand binding site [chemical binding]; other site 216592002039 dimerization interface (open form) [polypeptide binding]; other site 216592002040 dimerization interface (closed form) [polypeptide binding]; other site 216592002041 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.1e-09 216592002042 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.4e-11 216592002043 Predicted helix-turn-helix motif with score 2160.000, SD 6.54 at aa 4-25, sequence VTLYDVAEYAGVSYQTVSRVVN 216592002044 PS00356 Bacterial regulatory proteins, lacI family signature. 216592002045 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592002046 Present in 0157, absent in Uropathogenic, 3-hydroxyphenylpropionate degradation operons 216592002047 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 216592002048 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216592002049 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592002050 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 1.6e-07 216592002051 Predicted helix-turn-helix motif with score 1050.000, SD 2.76 at aa 21-42, sequence ASVGLLAELSGLHRTTVRRLLE 216592002052 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216592002053 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216592002054 HMMPfam hit to PF01494, FAD binding domain, score 7e-19 216592002055 HMMPfam hit to PF01360, Monooxygenase, score 1.9e-55 216592002056 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 216592002057 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 216592002058 putative active site [active] 216592002059 Fe(II) binding site [ion binding]; other site 216592002060 putative dimer interface [polypeptide binding]; other site 216592002061 putative tetramer interface [polypeptide binding]; other site 216592002062 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 3.4e-132 216592002063 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 216592002064 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 216592002065 nucleophilic elbow; other site 216592002066 catalytic triad; other site 216592002067 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2e-32 216592002068 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 216592002069 HMMPfam hit to PF01689, Hydratase/decarboxylase, score 3.1e-144 216592002070 Predicted helix-turn-helix motif with score 979.000, SD 2.52 at aa 52-73, sequence QGRRVVGRKVGLTHPKVQQQLG 216592002071 acetaldehyde dehydrogenase; Validated; Region: PRK08300 216592002072 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216592002073 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 216592002074 HMMPfam hit to PF02396, Acetaldehyde dehydrogenase, score 2.1e-248 216592002075 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 216592002076 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 216592002077 active site 216592002078 catalytic residues [active] 216592002079 metal binding site [ion binding]; metal-binding site 216592002080 DmpG-like communication domain; Region: DmpG_comm; pfam07836 216592002081 HMMPfam hit to PF00682, HMGL-like, score 1.7e-113 216592002082 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 216592002083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002085 HMMPfam hit to PF00083, Sugar (and other) transporter, score 8.7e-07 216592002086 12 probable transmembrane helices predicted for EC042_0390 by TMHMM2.0 at aa 37-59, 74-96, 105-124, 129-151, 164-186, 190-212, 242-264, 274-296, 303-322, 332-354, 361-383 and 393-415 216592002087 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-49 216592002088 PS00216 Sugar transport proteins signature 1. 216592002089 PS00217 Sugar transport proteins signature 2. 216592002090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 216592002091 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 216592002092 S-formylglutathione hydrolase; Region: PLN02442 216592002093 HMMPfam hit to PF00756, Putative esterase, score 1.2e-116 216592002094 PS00300 SRP54-type proteins GTP-binding domain signature. 216592002095 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 216592002096 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 216592002097 substrate binding site [chemical binding]; other site 216592002098 catalytic Zn binding site [ion binding]; other site 216592002099 NAD binding site [chemical binding]; other site 216592002100 structural Zn binding site [ion binding]; other site 216592002101 dimer interface [polypeptide binding]; other site 216592002102 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.5e-146 216592002103 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592002104 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 216592002105 putative metal binding site [ion binding]; other site 216592002106 putative homodimer interface [polypeptide binding]; other site 216592002107 putative homotetramer interface [polypeptide binding]; other site 216592002108 putative homodimer-homodimer interface [polypeptide binding]; other site 216592002109 putative allosteric switch controlling residues; other site 216592002110 HMMPfam hit to PF02583, Uncharacterised BCR, COG1937, score 4.6e-30 216592002111 Signal peptide predicted for EC042_0395 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 216592002112 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216592002113 putative trimer interface [polypeptide binding]; other site 216592002114 putative CoA binding site [chemical binding]; other site 216592002115 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 216592002116 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 22 216592002117 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.084 216592002118 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.45 216592002119 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 216592002120 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 216592002121 DXD motif; other site 216592002122 4 probable transmembrane helices predicted for EC042_0397 by TMHMM2.0 at aa 4-21, 269-291, 306-328 and 340-362 216592002123 HMMPfam hit to PF00535, Glycosyl transferase, score 1.6e-24 216592002124 Signal peptide predicted for EC042_0397 by SignalP 2.0 HMM (Signal peptide probability 0.850) with cleavage site probability 0.596 between residues 22 and 23 216592002125 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 216592002126 HMMPfam hit to PF02585, Uncharacterised LmbE-like protein, COG2120, score 1.2e-30 216592002127 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 216592002128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592002129 substrate binding pocket [chemical binding]; other site 216592002130 membrane-bound complex binding site; other site 216592002131 hinge residues; other site 216592002132 Signal peptide predicted for EC042_0399 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.956 between residues 22 and 23 216592002133 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 1.7e-44 216592002134 HMMPfam hit to PF06642, Taurine transport system periplasmic protein, score 2.3e-44 216592002135 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 216592002136 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216592002137 Walker A/P-loop; other site 216592002138 ATP binding site [chemical binding]; other site 216592002139 Q-loop/lid; other site 216592002140 ABC transporter signature motif; other site 216592002141 Walker B; other site 216592002142 D-loop; other site 216592002143 H-loop/switch region; other site 216592002144 HMMPfam hit to PF00005, ABC transporter, score 2.4e-57 216592002145 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002146 PS00211 ABC transporters family signature. 216592002147 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216592002148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592002149 dimer interface [polypeptide binding]; other site 216592002150 conserved gate region; other site 216592002151 putative PBP binding loops; other site 216592002152 ABC-ATPase subunit interface; other site 216592002153 Signal peptide predicted for EC042_0401 by SignalP 2.0 HMM (Signal peptide probability 0.907) with cleavage site probability 0.246 between residues 43 and 44 216592002154 6 probable transmembrane helices predicted for EC042_0401 by TMHMM2.0 at aa 20-42, 85-107, 119-141, 146-165, 186-208 and 236-258 216592002155 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.5e-23 216592002156 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592002157 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216592002158 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 216592002159 HMMPfam hit to PF02668, Taurine catabolism dioxygenase TauD, TfdA fa, score 1.6e-196 216592002160 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592002161 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 216592002162 dimer interface [polypeptide binding]; other site 216592002163 active site 216592002164 Schiff base residues; other site 216592002165 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 6.2e-236 216592002166 PS00169 Delta-aminolevulinic acid dehydratase active site. 216592002167 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 216592002168 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592002169 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592002170 Signal peptide predicted for EC042_0404 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.925 between residues 27 and 28 216592002171 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.3e-35 216592002172 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 216592002173 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 216592002174 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216592002175 HMMPfam hit to PF00144, Beta-lactamase, score 6.6e-72 216592002176 Signal peptide predicted for EC042_0406 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592002177 1 probable transmembrane helix predicted for EC042_0407 by TMHMM2.0 at aa 34-56 216592002178 microcin B17 transporter; Reviewed; Region: PRK11098 216592002179 Signal peptide predicted for EC042_0408 by SignalP 2.0 HMM (Signal peptide probability 0.914) with cleavage site probability 0.434 between residues 33 and 34 216592002180 8 probable transmembrane helices predicted for EC042_0408 by TMHMM2.0 at aa 7-29, 59-81, 88-110, 140-162, 208-230, 245-267, 311-329 and 339-361 216592002181 HMMPfam hit to PF05992, SbmA/BacA-like family, score 1.7e-103 216592002182 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 216592002183 Signal peptide predicted for EC042_0409 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.520 between residues 24 and 25 216592002184 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002185 HMMPfam hit to PF07759, Protein of unknown function (DUF1615), score 1.4e-246 216592002186 Predicted helix-turn-helix motif with score 1280.000, SD 3.55 at aa 277-298, sequence LATRKLAGKLGMSDSEIRRQLE 216592002187 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002188 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 216592002189 2 probable transmembrane helices predicted for EC042_0410 by TMHMM2.0 at aa 25-47 and 68-90 216592002190 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 216592002191 2 probable transmembrane helices predicted for EC042_0411 by TMHMM2.0 at aa 55-77 and 81-103 216592002192 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 216592002193 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216592002194 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 216592002195 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 2.1e-131 216592002196 PS00844 D-alanine--D-alanine ligase signature 2. 216592002197 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 1.2e-75 216592002198 PS00843 D-alanine--D-alanine ligase signature 1. 216592002199 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002200 1 probable transmembrane helix predicted for EC042_0414 by TMHMM2.0 at aa 34-51 216592002201 anti-RssB factor; Provisional; Region: PRK10244 216592002202 alkaline phosphatase; Provisional; Region: PRK10518 216592002203 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 216592002204 dimer interface [polypeptide binding]; other site 216592002205 active site 216592002206 Signal peptide predicted for EC042_0416 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.868 between residues 21 and 22 216592002207 HMMPfam hit to PF00245, Alkaline phosphatase, score 1.9e-160 216592002208 PS00123 Alkaline phosphatase active site. 216592002209 hypothetical protein; Provisional; Region: PRK11505 216592002210 psiF repeat; Region: PsiF_repeat; pfam07769 216592002211 psiF repeat; Region: PsiF_repeat; pfam07769 216592002212 Signal peptide predicted for EC042_0417 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.922 between residues 21 and 22 216592002213 1 probable transmembrane helix predicted for EC042_0417 by TMHMM2.0 at aa 5-22 216592002214 HMMPfam hit to PF07769, psiF repeat, score 3.6e-19 216592002215 HMMPfam hit to PF07769, psiF repeat, score 1.1e-21 216592002216 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 216592002217 MASE2 domain; Region: MASE2; pfam05230 216592002218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592002219 metal binding site [ion binding]; metal-binding site 216592002220 active site 216592002221 I-site; other site 216592002222 HMMPfam hit to PF05230, MASE2 domain, score 6e-120 216592002223 5 probable transmembrane helices predicted for EC042_0418 by TMHMM2.0 at aa 41-63, 68-87, 108-130, 145-167 and 174-196 216592002224 HMMPfam hit to PF00990, GGDEF domain, score 3.4e-73 216592002225 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 216592002226 pyrroline-5-carboxylate reductase; Region: PLN02688 216592002227 HMMPfam hit to PF01089, Delta 1-pyrroline-5-carboxylate reductase, score 5.9e-137 216592002228 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 216592002229 hypothetical protein; Validated; Region: PRK00124 216592002230 HMMPfam hit to PF02639, Uncharacterized BCR, YaiI/YqxD family COG167, score 4.4e-96 216592002231 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 216592002232 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 216592002233 ADP binding site [chemical binding]; other site 216592002234 magnesium binding site [ion binding]; other site 216592002235 putative shikimate binding site; other site 216592002236 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002237 HMMPfam hit to PF01202, Shikimate kinase, score 8.6e-69 216592002238 PS01128 Shikimate kinase signature. 216592002239 hypothetical protein; Provisional; Region: PRK10380 216592002240 hypothetical protein; Provisional; Region: PRK10481 216592002241 HMMPfam hit to PF07302, AroM protein, score 2.6e-149 216592002242 hypothetical protein; Provisional; Region: PRK10579 216592002243 HMMPfam hit to PF06865, Protein of unknown function (DUF1255), score 3.2e-64 216592002244 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 216592002245 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 216592002246 HMMPfam hit to PF04381, Putative exonuclease, RdgC, score 6.5e-225 216592002247 fructokinase; Reviewed; Region: PRK09557 216592002248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592002249 nucleotide binding site [chemical binding]; other site 216592002250 HMMPfam hit to PF00480, ROK family, score 2.4e-96 216592002251 PS01125 ROK family signature. 216592002252 MFS transport protein AraJ; Provisional; Region: PRK10091 216592002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002254 putative substrate translocation pore; other site 216592002255 13 probable transmembrane helices predicted for EC042_0428 by TMHMM2.0 at aa 5-25, 32-54, 69-91, 98-117, 122-144, 156-178, 188-207, 228-250, 265-287, 294-316, 321-343, 348-370 and 380-402 216592002256 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.5e-49 216592002257 Predicted helix-turn-helix motif with score 1096.000, SD 2.92 at aa 52-73, sequence GVLTELAHNVGISIPAAGHMIS 216592002258 exonuclease subunit SbcC; Provisional; Region: PRK10246 216592002259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592002260 Walker A/P-loop; other site 216592002261 ATP binding site [chemical binding]; other site 216592002262 Q-loop/lid; other site 216592002263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592002264 ABC transporter signature motif; other site 216592002265 Walker B; other site 216592002266 D-loop; other site 216592002267 H-loop/switch region; other site 216592002268 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002269 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 5.3e-06 216592002270 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002271 exonuclease subunit SbcD; Provisional; Region: PRK10966 216592002272 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 216592002273 active site 216592002274 metal binding site [ion binding]; metal-binding site 216592002275 DNA binding site [nucleotide binding] 216592002276 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 216592002277 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.5e-19 216592002278 transcriptional regulator PhoB; Provisional; Region: PRK10161 216592002279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592002280 active site 216592002281 phosphorylation site [posttranslational modification] 216592002282 intermolecular recognition site; other site 216592002283 dimerization interface [polypeptide binding]; other site 216592002284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592002285 DNA binding site [nucleotide binding] 216592002286 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-41 216592002287 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.9e-25 216592002288 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 216592002289 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 216592002290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592002291 putative active site [active] 216592002292 heme pocket [chemical binding]; other site 216592002293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592002294 dimer interface [polypeptide binding]; other site 216592002295 phosphorylation site [posttranslational modification] 216592002296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592002297 ATP binding site [chemical binding]; other site 216592002298 Mg2+ binding site [ion binding]; other site 216592002299 G-X-G motif; other site 216592002300 Signal peptide predicted for EC042_0432 by SignalP 2.0 HMM (Signal peptide probability 0.733) with cleavage site probability 0.635 between residues 37 and 38 216592002301 1 probable transmembrane helix predicted for EC042_0432 by TMHMM2.0 at aa 12-34 216592002302 HMMPfam hit to PF00989, PAS domain, score 1.4e-09 216592002303 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.1e-25 216592002304 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.3e-44 216592002305 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 216592002306 Signal peptide predicted for EC042_0433 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.685 between residues 24 and 25 216592002307 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 2.5e-238 216592002308 12 probable transmembrane helices predicted for EC042_0433 by TMHMM2.0 at aa 13-35, 41-63, 76-98, 118-140, 147-169, 189-211, 223-245, 276-298, 305-327, 337-359, 371-393 and 408-426 216592002309 putative proline-specific permease; Provisional; Region: proY; PRK10580 216592002310 Spore germination protein; Region: Spore_permease; cl17796 216592002311 Signal peptide predicted for EC042_0434 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.351 between residues 36 and 37 216592002312 HMMPfam hit to PF00324, Amino acid permease, score 5.1e-133 216592002313 12 probable transmembrane helices predicted for EC042_0434 by TMHMM2.0 at aa 16-35, 45-64, 84-106, 121-143, 155-177, 197-219, 240-262, 277-299, 330-352, 357-379, 400-422 and 427-446 216592002314 PS00218 Amino acid permeases signature. 216592002315 maltodextrin glucosidase; Provisional; Region: PRK10785 216592002316 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 216592002317 homodimer interface [polypeptide binding]; other site 216592002318 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 216592002319 active site 216592002320 homodimer interface [polypeptide binding]; other site 216592002321 catalytic site [active] 216592002322 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.1e-118 216592002323 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 216592002324 HMMPfam hit to PF04336, Protein of unknown function, DUF479, score 1.3e-137 216592002325 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 216592002326 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 216592002327 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3.5e-153 216592002328 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 216592002329 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 216592002330 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 3e-172 216592002331 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 216592002332 HMMPfam hit to PF02699, Preprotein translocase subunit, score 3.9e-48 216592002333 1 probable transmembrane helix predicted for EC042_0440 by TMHMM2.0 at aa 20-39 216592002334 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 216592002335 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 216592002336 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 216592002337 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 216592002338 Signal peptide predicted for EC042_0441 by SignalP 2.0 HMM (Signal peptide probability 0.784) with cleavage site probability 0.510 between residues 30 and 31 216592002339 6 probable transmembrane helices predicted for EC042_0441 by TMHMM2.0 at aa 7-29, 450-472, 475-497, 502-524, 548-570 and 580-602 216592002340 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 6.1e-05 216592002341 PS00761 Signal peptidases I signature 3. 216592002342 HMMPfam hit to PF02355, Protein export membrane protein, score 2.9e-06 216592002343 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 216592002344 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 216592002345 Protein export membrane protein; Region: SecD_SecF; pfam02355 216592002346 6 probable transmembrane helices predicted for EC042_0442 by TMHMM2.0 at aa 39-61, 158-177, 184-206, 210-232, 263-285 and 290-312 216592002347 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.2e-05 216592002348 HMMPfam hit to PF02355, Protein export membrane protein, score 3.7e-95 216592002349 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 216592002350 HMMPfam hit to PF03693, Uncharacterised protein family (UPF0156), score 2.2e-54 216592002351 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216592002352 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 3.8e-15 216592002353 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216592002354 active site 216592002355 HMMPfam hit to PF01844, HNH endonuclease, score 3.9e-06 216592002356 PS00190 Cytochrome c family heme-binding site signature. 216592002357 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 216592002358 HMMPfam hit to PF03502, Nucleoside-specific channel-forming prote, score 2.3e-121 216592002359 Signal peptide predicted for EC042_0446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 216592002360 hypothetical protein; Provisional; Region: PRK11530 216592002361 Signal peptide predicted for EC042_0447 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.442 between residues 23 and 24 216592002362 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002363 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 216592002364 ATP cone domain; Region: ATP-cone; pfam03477 216592002365 HMMPfam hit to PF03477, ATP cone domain, score 2.3e-34 216592002366 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 216592002367 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216592002368 catalytic motif [active] 216592002369 Zn binding site [ion binding]; other site 216592002370 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 216592002371 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 3.3e-49 216592002372 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216592002373 HMMPfam hit to PF01872, RibD C-terminal domain, score 1.2e-98 216592002374 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 216592002375 homopentamer interface [polypeptide binding]; other site 216592002376 active site 216592002377 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 1.9e-92 216592002378 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 216592002379 putative RNA binding site [nucleotide binding]; other site 216592002380 HMMPfam hit to PF01029, NusB family, score 9.2e-52 216592002381 thiamine monophosphate kinase; Provisional; Region: PRK05731 216592002382 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 216592002383 ATP binding site [chemical binding]; other site 216592002384 dimerization interface [polypeptide binding]; other site 216592002385 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 2.1e-06 216592002386 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 216592002387 tetramer interfaces [polypeptide binding]; other site 216592002388 binuclear metal-binding site [ion binding]; other site 216592002389 Signal peptide predicted for EC042_0453 by SignalP 2.0 HMM (Signal peptide probability 0.748) with cleavage site probability 0.544 between residues 44 and 45 216592002390 HMMPfam hit to PF04608, Phosphatidylglycerophosphatase A, score 3.8e-95 216592002391 3 probable transmembrane helices predicted for EC042_0453 by TMHMM2.0 at aa 21-43, 53-75 and 140-162 216592002392 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 216592002393 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 408-429, sequence ISRKKYNEIFNYKQEQARQYFI 216592002394 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 0.00078 216592002395 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 5.7e-09 216592002396 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592002397 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592002398 active site 216592002399 catalytic tetrad [active] 216592002400 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.8e-67 216592002401 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 216592002402 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 216592002403 TPP-binding site; other site 216592002404 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216592002405 PYR/PP interface [polypeptide binding]; other site 216592002406 dimer interface [polypeptide binding]; other site 216592002407 TPP binding site [chemical binding]; other site 216592002408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216592002409 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 2.9e-39 216592002410 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 6.5e-63 216592002411 PS00802 Transketolase signature 2. 216592002412 PS00801 Transketolase signature 1. 216592002413 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216592002414 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216592002415 substrate binding pocket [chemical binding]; other site 216592002416 chain length determination region; other site 216592002417 substrate-Mg2+ binding site; other site 216592002418 catalytic residues [active] 216592002419 aspartate-rich region 1; other site 216592002420 active site lid residues [active] 216592002421 aspartate-rich region 2; other site 216592002422 HMMPfam hit to PF00348, Polyprenyl synthetase, score 2.8e-137 216592002423 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002424 PS00444 Polyprenyl synthetases signature 2. 216592002425 PS00723 Polyprenyl synthetases signature 1. 216592002426 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 216592002427 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 1.7e-34 216592002428 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 216592002429 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 216592002430 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 216592002431 Ligand Binding Site [chemical binding]; other site 216592002432 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216592002433 active site residue [active] 216592002434 HMMPfam hit to PF02926, THUMP domain, score 4.1e-28 216592002435 HMMPfam hit to PF02568, Thiamine biosynthesis protein (ThiI), score 1.1e-112 216592002436 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 216592002437 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 216592002438 conserved cys residue [active] 216592002439 HMMPfam hit to PF01965, DJ-1/PfpI family, score 4.2e-47 216592002440 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 216592002441 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 216592002442 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216592002443 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 7.9e-127 216592002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 216592002445 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 216592002446 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 5.2e-119 216592002447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592002449 putative substrate translocation pore; other site 216592002450 12 probable transmembrane helices predicted for EC042_0465 by TMHMM2.0 at aa 79-101, 116-138, 145-164, 168-190, 203-225, 230-252, 283-305, 320-339, 346-368, 372-394, 407-429 and 434-451 216592002451 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.3e-45 216592002452 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 216592002453 UbiA prenyltransferase family; Region: UbiA; pfam01040 216592002454 9 probable transmembrane helices predicted for EC042_0466 by TMHMM2.0 at aa 12-34, 38-60, 81-103, 108-127, 134-156, 161-183, 209-231, 235-252 and 264-286 216592002455 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.4e-86 216592002456 PS00943 UbiA prenyltransferase family signature. 216592002457 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 216592002458 3 probable transmembrane helices predicted for EC042_0467 by TMHMM2.0 at aa 33-55, 59-81 and 93-115 216592002459 HMMPfam hit to PF03626, Prokaryotic Cytochrome C oxidase subunit IV, score 3.8e-53 216592002460 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 216592002461 Subunit I/III interface [polypeptide binding]; other site 216592002462 Subunit III/IV interface [polypeptide binding]; other site 216592002463 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 6.7e-06 216592002464 5 probable transmembrane helices predicted for EC042_0468 by TMHMM2.0 at aa 27-49, 69-91, 98-118, 138-160 and 181-203 216592002465 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216592002466 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 216592002467 D-pathway; other site 216592002468 Putative ubiquinol binding site [chemical binding]; other site 216592002469 Low-spin heme (heme b) binding site [chemical binding]; other site 216592002470 Putative water exit pathway; other site 216592002471 Binuclear center (heme o3/CuB) [ion binding]; other site 216592002472 K-pathway; other site 216592002473 Putative proton exit pathway; other site 216592002474 14 probable transmembrane helices predicted for EC042_0469 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 457-479, 494-516 and 590-612 216592002475 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 4.1e-270 216592002476 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216592002477 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 216592002478 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216592002479 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 216592002480 HMMPfam hit to PF06481, COX Aromatic Rich Motif, score 8.1e-17 216592002481 3 probable transmembrane helices predicted for EC042_0470 by TMHMM2.0 at aa 12-30, 45-67 and 88-110 216592002482 Signal peptide predicted for EC042_0470 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.646 between residues 30 and 31 216592002483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002484 muropeptide transporter; Reviewed; Region: ampG; PRK11902 216592002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002486 putative substrate translocation pore; other site 216592002487 14 probable transmembrane helices predicted for EC042_0471 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 109-131, 144-166, 176-195, 223-245, 260-282, 287-309, 319-341, 354-376, 380-402, 423-445 and 458-480 216592002488 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-29 216592002489 Signal peptide predicted for EC042_0471 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.596 between residues 37 and 38 216592002490 hypothetical protein; Provisional; Region: PRK11627 216592002491 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 216592002492 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 9.3e-07 216592002493 transcriptional regulator BolA; Provisional; Region: PRK11628 216592002494 HMMPfam hit to PF01722, BolA-like protein, score 3.7e-41 216592002495 trigger factor; Provisional; Region: tig; PRK01490 216592002496 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216592002497 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 216592002498 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 1e-73 216592002499 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 5.5e-27 216592002500 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 6.4e-61 216592002501 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 216592002502 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216592002503 oligomer interface [polypeptide binding]; other site 216592002504 active site residues [active] 216592002505 HMMPfam hit to PF00574, Clp protease, score 1.2e-139 216592002506 PS00381 Endopeptidase Clp serine active site. 216592002507 PS00382 Endopeptidase Clp histidine active site. 216592002508 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 216592002509 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 216592002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592002511 Walker A motif; other site 216592002512 ATP binding site [chemical binding]; other site 216592002513 Walker B motif; other site 216592002514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216592002515 HMMPfam hit to PF06689, ClpX C4-type zinc finger, score 3e-26 216592002516 HMMPfam hit to PF07724, ATPase family associated with various cell, score 6.1e-79 216592002517 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1e-23 216592002518 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002519 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 216592002520 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216592002521 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216592002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592002523 Walker A motif; other site 216592002524 ATP binding site [chemical binding]; other site 216592002525 Walker B motif; other site 216592002526 arginine finger; other site 216592002527 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216592002528 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 2.4e-83 216592002529 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592002530 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.2e-42 216592002531 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002532 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 1.1e-156 216592002533 PS01046 ATP-dependent serine proteases, lon family, serine active site. 216592002534 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216592002535 IHF dimer interface [polypeptide binding]; other site 216592002536 IHF - DNA interface [nucleotide binding]; other site 216592002537 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 5.3e-49 216592002538 PS00045 Bacterial histone-like DNA-binding proteins signature. 216592002539 periplasmic folding chaperone; Provisional; Region: PRK10788 216592002540 SurA N-terminal domain; Region: SurA_N_3; cl07813 216592002541 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 216592002542 1 probable transmembrane helix predicted for EC042_0479 by TMHMM2.0 at aa 13-35 216592002543 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 2.4e-18 216592002544 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216592002545 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 216592002546 Signal peptide predicted for EC042_0480 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 25 and 26 216592002547 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.25 216592002548 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.9 216592002549 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216592002550 active site 216592002551 HMMPfam hit to PF03061, Thioesterase superfamily, score 2.9e-13 216592002552 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 216592002553 Ligand Binding Site [chemical binding]; other site 216592002554 HMMPfam hit to PF06508, ExsB, score 2.4e-46 216592002555 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 216592002556 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 216592002557 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 216592002558 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.7e-23 216592002559 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 24-45, sequence VTVSELAERCFCSERHVRTLLR 216592002560 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 216592002561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592002562 active site 216592002563 motif I; other site 216592002564 motif II; other site 216592002565 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-13 216592002566 PS01228 Hypothetical cof family signature 1. 216592002567 PS01229 Hypothetical cof family signature 2. 216592002568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592002569 dimerization interface [polypeptide binding]; other site 216592002570 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216592002571 putative DNA binding site [nucleotide binding]; other site 216592002572 putative Zn2+ binding site [ion binding]; other site 216592002573 AsnC family; Region: AsnC_trans_reg; pfam01037 216592002574 Predicted helix-turn-helix motif with score 1271.000, SD 3.52 at aa 55-76, sequence LSLQALAEAVNLTTTPCWKRLK 216592002575 PS00519 Bacterial regulatory proteins, asnC family signature. 216592002576 HMMPfam hit to PF01037, AsnC family, score 2.6e-55 216592002577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592002578 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 216592002579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592002580 Walker A/P-loop; other site 216592002581 ATP binding site [chemical binding]; other site 216592002582 Q-loop/lid; other site 216592002583 ABC transporter signature motif; other site 216592002584 Walker B; other site 216592002585 D-loop; other site 216592002586 H-loop/switch region; other site 216592002587 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 3.4e-65 216592002588 6 probable transmembrane helices predicted for EC042_0486 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 246-268 and 278-300 216592002589 HMMPfam hit to PF00005, ABC transporter, score 3.6e-52 216592002590 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002591 PS00211 ABC transporters family signature. 216592002592 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 216592002593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592002594 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216592002595 Walker A/P-loop; other site 216592002596 ATP binding site [chemical binding]; other site 216592002597 Q-loop/lid; other site 216592002598 ABC transporter signature motif; other site 216592002599 Walker B; other site 216592002600 D-loop; other site 216592002601 H-loop/switch region; other site 216592002602 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.9e-33 216592002603 5 probable transmembrane helices predicted for EC042_0487 by TMHMM2.0 at aa 63-85, 105-127, 176-198, 203-223 and 287-309 216592002604 HMMPfam hit to PF00005, ABC transporter, score 1.2e-46 216592002605 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002606 PS00211 ABC transporters family signature. 216592002607 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002608 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 216592002609 Nitrogen regulatory protein P-II; Region: P-II; smart00938 216592002610 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 9.1e-64 216592002611 PS00496 P-II protein urydylation site. 216592002612 PS00638 P-II protein C-terminal region signature. 216592002613 ammonium transporter; Provisional; Region: PRK10666 216592002614 Signal peptide predicted for EC042_0489 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.664 between residues 27 and 28 216592002615 12 probable transmembrane helices predicted for EC042_0489 by TMHMM2.0 at aa 9-26, 36-58, 63-85, 120-142, 149-171, 186-205, 218-237, 247-269, 281-303, 307-324, 337-359 and 374-396 216592002616 HMMPfam hit to PF00909, Ammonium Transporter Family, score 7e-195 216592002617 PS01219 Ammonium transporters signature. 216592002618 acyl-CoA thioesterase II; Provisional; Region: PRK10526 216592002619 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216592002620 active site 216592002621 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216592002622 catalytic triad [active] 216592002623 dimer interface [polypeptide binding]; other site 216592002624 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.8e-79 216592002625 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 1.9e-48 216592002626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 216592002627 Signal peptide predicted for EC042_0491 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.552 between residues 20 and 21 216592002628 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002629 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216592002630 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216592002631 DNA binding site [nucleotide binding] 216592002632 active site 216592002633 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferas, score 2.6e-46 216592002634 Uncharacterized conserved protein [Function unknown]; Region: COG5507 216592002635 HMMPfam hit to PF07237, Protein of unknown function (DUF1428), score 1.5e-86 216592002636 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 216592002637 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216592002638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592002639 HMMPfam hit to PF00563, EAL domain, score 3e-106 216592002640 2 probable transmembrane helices predicted for EC042_0494 by TMHMM2.0 at aa 7-29 and 245-267 216592002641 Signal peptide predicted for EC042_0494 by SignalP 2.0 HMM (Signal peptide probability 0.830) with cleavage site probability 0.766 between residues 33 and 34 216592002642 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 216592002643 2 probable transmembrane helices predicted for EC042_0495 by TMHMM2.0 at aa 49-68 and 73-92 216592002644 maltose O-acetyltransferase; Provisional; Region: PRK10092 216592002645 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 216592002646 active site 216592002647 substrate binding site [chemical binding]; other site 216592002648 trimer interface [polypeptide binding]; other site 216592002649 CoA binding site [chemical binding]; other site 216592002650 PS00101 Hexapeptide-repeat containing-transferases signature. 216592002651 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.086 216592002652 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.27 216592002653 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.038 216592002654 gene expression modulator; Provisional; Region: PRK10945 216592002655 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 1.3e-37 216592002656 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 216592002657 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 216592002658 Protein export membrane protein; Region: SecD_SecF; cl14618 216592002659 Protein export membrane protein; Region: SecD_SecF; cl14618 216592002660 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592002661 11 probable transmembrane helices predicted for EC042_0500 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 542-564, 873-892, 899-921, 926-948, 975-997 and 1007-1029 216592002662 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002663 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 216592002664 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592002665 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592002666 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.7e-95 216592002667 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002668 Signal peptide predicted for EC042_0501 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.620 between residues 24 and 25 216592002669 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 216592002670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592002671 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 216592002672 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2e-22 216592002673 PS01081 Bacterial regulatory proteins, tetR family signature. 216592002674 Predicted helix-turn-helix motif with score 2256.000, SD 6.87 at aa 32-53, sequence TSLGEIAKAAGVTRGAIYWHFK 216592002675 hypothetical protein; Provisional; Region: PRK11281 216592002676 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 216592002677 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 216592002678 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592002679 Signal peptide predicted for EC042_0503 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.829 between residues 33 and 34 216592002680 12 probable transmembrane helices predicted for EC042_0503 by TMHMM2.0 at aa 13-32, 500-522, 557-579, 584-606, 630-647, 658-680, 693-715, 725-747, 795-817, 837-859, 880-902 and 917-939 216592002681 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 2.3e-85 216592002682 PS01246 Uncharacterized protein family UPF0003 signature. 216592002683 hypothetical protein; Provisional; Region: PRK11038 216592002684 primosomal replication protein N''; Provisional; Region: PRK10093 216592002685 HMMPfam hit to PF07445, Primosomal replication protein priB and pri, score 6.4e-102 216592002686 hypothetical protein; Provisional; Region: PRK10527 216592002687 Signal peptide predicted for EC042_0506 by SignalP 2.0 HMM (Signal peptide probability 0.665) with cleavage site probability 0.323 between residues 35 and 36 216592002688 4 probable transmembrane helices predicted for EC042_0506 by TMHMM2.0 at aa 7-26, 46-63, 75-92 and 96-118 216592002689 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 1.5e-38 216592002690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592002691 active site 216592002692 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3.9e-52 216592002693 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592002694 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 216592002695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592002696 Walker A motif; other site 216592002697 ATP binding site [chemical binding]; other site 216592002698 Walker B motif; other site 216592002699 DNA polymerase III subunit delta'; Validated; Region: PRK08485 216592002700 arginine finger; other site 216592002701 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 216592002702 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 216592002703 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 216592002704 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.4e-10 216592002705 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002706 PS00215 Mitochondrial energy transfer proteins signature. 216592002707 hypothetical protein; Validated; Region: PRK00153 216592002708 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 7.7e-53 216592002709 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 216592002710 RecR protein; Region: RecR; pfam02132 216592002711 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 216592002712 putative active site [active] 216592002713 putative metal-binding site [ion binding]; other site 216592002714 tetramer interface [polypeptide binding]; other site 216592002715 HMMPfam hit to PF02132, RecR protein, score 3.1e-22 216592002716 PS01300 RecR protein signature. 216592002717 HMMPfam hit to PF01751, Toprim domain, score 5.6e-24 216592002718 heat shock protein 90; Provisional; Region: PRK05218 216592002719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592002720 ATP binding site [chemical binding]; other site 216592002721 Mg2+ binding site [ion binding]; other site 216592002722 G-X-G motif; other site 216592002723 PS00298 Heat shock hsp90 proteins family signature. 216592002724 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 9.8e-18 216592002725 HMMPfam hit to PF00183, Hsp90 protein, score 6e-85 216592002726 adenylate kinase; Reviewed; Region: adk; PRK00279 216592002727 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216592002728 AMP-binding site [chemical binding]; other site 216592002729 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216592002730 HMMPfam hit to PF00406, Adenylate kinase, score 7.4e-97 216592002731 PS00113 Adenylate kinase signature. 216592002732 HMMPfam hit to PF05191, Adenylate kinase, active site lid, score 1.7e-21 216592002733 ferrochelatase; Region: hemH; TIGR00109 216592002734 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 216592002735 C-terminal domain interface [polypeptide binding]; other site 216592002736 active site 216592002737 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 216592002738 active site 216592002739 N-terminal domain interface [polypeptide binding]; other site 216592002740 HMMPfam hit to PF00762, Ferrochelatase, score 1.9e-171 216592002741 PS00534 Ferrochelatase signature. 216592002742 Predicted helix-turn-helix motif with score 1095.000, SD 2.92 at aa 213-234, sequence TTTRELASALGMAPEKVMMTFQ 216592002743 acetyl esterase; Provisional; Region: PRK10162 216592002744 PS01174 Lipolytic enzymes ''G-D-X-G'' family, putative serine active site. 216592002745 PS01173 Lipolytic enzymes ''G-D-X-G'' family, putative histidine active site. 216592002746 inosine/guanosine kinase; Provisional; Region: PRK15074 216592002747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592002748 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.9e-22 216592002749 PS00584 pfkB family of carbohydrate kinases signature 2. 216592002750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592002751 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592002752 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592002753 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 20-41, sequence AGIISTAKLFQLSHTSLSHWIN 216592002754 HTH-like domain; Region: HTH_21; pfam13276 216592002755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592002756 Integrase core domain; Region: rve; pfam00665 216592002757 Integrase core domain; Region: rve_2; pfam13333 216592002758 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002759 HMMPfam hit to PF00665, Integrase core domain, score 5.7e-45 216592002760 putative cation:proton antiport protein; Provisional; Region: PRK10669 216592002761 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 216592002762 TrkA-N domain; Region: TrkA_N; pfam02254 216592002763 HMMPfam hit to PF02254, TrkA-N domain, score 2.2e-39 216592002764 12 probable transmembrane helices predicted for EC042_0518 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 184-206, 226-248, 280-299, 302-324, 339-361 and 368-387 216592002765 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592002767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592002768 putative substrate translocation pore; other site 216592002769 10 probable transmembrane helices predicted for EC042_0519 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399 216592002770 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.6e-39 216592002771 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 216592002772 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 216592002773 active site 216592002774 metal binding site [ion binding]; metal-binding site 216592002775 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216592002776 Signal peptide predicted for EC042_0520 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.875 between residues 25 and 26 216592002777 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 4.4e-19 216592002778 PS00785 5'-nucleotidase signature 1. 216592002779 PS00786 5'-nucleotidase signature 2. 216592002780 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.8e-56 216592002781 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 216592002782 putative deacylase active site [active] 216592002783 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 9.4e-80 216592002784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 216592002785 HMMPfam hit to PF07446, GumN protein, score 2.8e-07 216592002786 copper exporting ATPase; Provisional; Region: copA; PRK10671 216592002787 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216592002788 metal-binding site [ion binding] 216592002789 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216592002790 metal-binding site [ion binding] 216592002791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216592002792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592002793 motif II; other site 216592002794 8 probable transmembrane helices predicted for EC042_0523 by TMHMM2.0 at aa 189-206, 216-238, 245-267, 282-299, 436-458, 463-485, 778-797 and 802-824 216592002795 Predicted helix-turn-helix motif with score 1316.000, SD 3.67 at aa 755-776, sequence HSLMGVADALAISRATLRNMKQ 216592002796 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 6.5e-41 216592002797 PS01229 Hypothetical cof family signature 2. 216592002798 PS00154 E1-E2 ATPases phosphorylation site. 216592002799 HMMPfam hit to PF00122, E1-E2 ATPase, score 2.5e-95 216592002800 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.2e-16 216592002801 PS01047 Heavy-metal-associated domain. 216592002802 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 3.6e-10 216592002803 PS01047 Heavy-metal-associated domain. 216592002804 glutaminase; Reviewed; Region: PRK12356 216592002805 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 216592002806 HMMPfam hit to PF04960, Glutaminase, score 1.9e-175 216592002807 amino acid transporter; Region: 2A0306; TIGR00909 216592002808 12 probable transmembrane helices predicted for EC042_0525 by TMHMM2.0 at aa 13-35, 45-67, 88-110, 130-149, 156-178, 193-215, 228-250, 278-300, 321-343, 348-367, 374-396 and 406-423 216592002809 HMMPfam hit to PF00324, Amino acid permease, score 4.2e-07 216592002810 PS00041 Bacterial regulatory proteins, araC family signature. 216592002811 Present in 0157, absent in Uropathogenic, RTX-family protein (pseudogene?), transporter proteins (ABC, efflux, HlyD), YadA domain protein 216592002812 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216592002813 Signal peptide predicted for EC042_0526 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.672 between residues 29 and 30 216592002814 1 probable transmembrane helix predicted for EC042_0526 by TMHMM2.0 at aa 13-35 216592002815 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.2e-23 216592002816 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.1e-21 216592002818 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592002819 HMMPfam hit to PF05594, no description, score 9.8 216592002820 Signal peptide predicted for EC042_0530 by SignalP 2.0 HMM (Signal peptide probability 0.860) with cleavage site probability 0.553 between residues 22 and 23 216592002821 HMMPfam hit to PF03423, Carbohydrate binding domain (family, score 0.035 216592002822 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 0.19 216592002823 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 0.42 216592002824 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 0.21 216592002825 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 0.12 216592002826 HMMPfam hit to PF02012, BNR/Asp-box repeat, score 2 216592002827 HMMPfam hit to PF01839, FG-GAP repeat, score 0.027 216592002828 HMMPfam hit to PF01839, FG-GAP repeat, score 0.026 216592002829 HMMPfam hit to PF01839, FG-GAP repeat, score 0.0047 216592002830 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 1.6 216592002831 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.036 216592002832 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 6.2 216592002833 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 216592002834 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592002835 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 216592002836 Walker A/P-loop; other site 216592002837 ATP binding site [chemical binding]; other site 216592002838 Q-loop/lid; other site 216592002839 ABC transporter signature motif; other site 216592002840 Walker B; other site 216592002841 D-loop; other site 216592002842 H-loop/switch region; other site 216592002843 3 probable transmembrane helices predicted for EC042_0531 by TMHMM2.0 at aa 162-184, 194-211 and 282-304 216592002844 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 7.5e-19 216592002845 HMMPfam hit to PF00005, ABC transporter, score 1.8e-48 216592002846 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002847 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592002848 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216592002849 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 216592002850 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592002851 1 probable transmembrane helix predicted for EC042_0532 by TMHMM2.0 at aa 20-42 216592002852 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.4e-19 216592002853 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592002854 PS00543 HlyD family secretion proteins signature. 216592002855 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 216592002856 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 216592002857 DNA binding residues [nucleotide binding] 216592002858 dimer interface [polypeptide binding]; other site 216592002859 copper binding site [ion binding]; other site 216592002860 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 1-22, sequence MNISDVAKITGLTSKAIRFYEE 216592002861 HMMPfam hit to PF00376, MerR family regulatory protein, score 6.2e-13 216592002862 PS00552 Bacterial regulatory proteins, merR family signature. 216592002863 Signal peptide predicted for EC042_0534 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.975 between residues 34 and 35 216592002864 1 probable transmembrane helix predicted for EC042_0534 by TMHMM2.0 at aa 7-29 216592002865 Signal peptide predicted for EC042_0535 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.617 between residues 28 and 29 216592002866 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002867 YadA-like C-terminal region; Region: YadA; pfam03895 216592002868 HMMPfam hit to PF03895, YadA-like C-terminal region, score 8e-16 216592002869 Signal peptide predicted for EC042_0536 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 216592002870 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 216592002871 HMMPfam hit to PF01957, Nodulation efficiency protein D (NfeD), score 4e-39 216592002872 3 probable transmembrane helices predicted for EC042_0538 by TMHMM2.0 at aa 4-23, 30-49 and 53-75 216592002873 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216592002874 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 216592002875 HMMPfam hit to PF01145, SPFH domain / Band, score 7.5e-75 216592002876 PS01270 Band 7 protein family signature. 216592002877 1 probable transmembrane helix predicted for EC042_0539 by TMHMM2.0 at aa 7-29 216592002878 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002879 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 216592002880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592002881 Walker A/P-loop; other site 216592002882 ATP binding site [chemical binding]; other site 216592002883 Q-loop/lid; other site 216592002884 ABC transporter signature motif; other site 216592002885 Walker B; other site 216592002886 D-loop; other site 216592002887 H-loop/switch region; other site 216592002888 HMMPfam hit to PF00005, ABC transporter, score 2.1e-49 216592002889 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002890 PS00211 ABC transporters family signature. 216592002891 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 216592002892 HMMPfam hit to PF03649, Uncharacterised protein family (UPF0014), score 5e-180 216592002893 7 probable transmembrane helices predicted for EC042_0541 by TMHMM2.0 at aa 15-33, 45-67, 72-89, 101-123, 133-155, 201-218 and 228-250 216592002894 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 216592002895 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 216592002896 HMMPfam hit to PF00085, Thioredoxin, score 1.3e-17 216592002897 oxidoreductase; Provisional; Region: PRK08017 216592002898 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216592002899 NADP binding site [chemical binding]; other site 216592002900 active site 216592002901 steroid binding site; other site 216592002902 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.3e-36 216592002903 PS00061 Short-chain dehydrogenases/reductases family signature. 216592002904 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 216592002905 active site 216592002906 catalytic triad [active] 216592002907 oxyanion hole [active] 216592002908 switch loop; other site 216592002909 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 3.3e-37 216592002910 PS01098 Lipolytic enzymes ''G-D-S-L'' family, serine active site. 216592002911 1 probable transmembrane helix predicted for EC042_0544 by TMHMM2.0 at aa 21-43 216592002912 Signal peptide predicted for EC042_0544 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.762 between residues 36 and 37 216592002913 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 216592002914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216592002915 Walker A/P-loop; other site 216592002916 ATP binding site [chemical binding]; other site 216592002917 Q-loop/lid; other site 216592002918 ABC transporter signature motif; other site 216592002919 Walker B; other site 216592002920 D-loop; other site 216592002921 H-loop/switch region; other site 216592002922 HMMPfam hit to PF00005, ABC transporter, score 3e-60 216592002923 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002924 PS00211 ABC transporters family signature. 216592002925 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 216592002926 FtsX-like permease family; Region: FtsX; pfam02687 216592002927 FtsX-like permease family; Region: FtsX; pfam02687 216592002928 Signal peptide predicted for EC042_0546 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.507 between residues 33 and 34 216592002929 10 probable transmembrane helices predicted for EC042_0546 by TMHMM2.0 at aa 13-35, 243-262, 291-313, 333-355, 376-398, 403-425, 451-473, 676-698, 732-754 and 769-791 216592002930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592002931 HMMPfam hit to PF02687, Predicted permease, score 9.8e-13 216592002932 HMMPfam hit to PF02687, Predicted permease, score 1.2e-08 216592002933 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 216592002934 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 216592002935 active site residue [active] 216592002936 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002937 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 216592002938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592002939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592002940 dimerization interface [polypeptide binding]; other site 216592002941 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-19 216592002942 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.5e-18 216592002943 Predicted helix-turn-helix motif with score 1773.000, SD 5.23 at aa 17-38, sequence GSFSKAAERLCKTTATISYRIK 216592002944 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 216592002945 ureidoglycolate hydrolase; Provisional; Region: PRK03606 216592002946 HMMPfam hit to PF04115, Ureidoglycolate hydrolase, score 1.9e-104 216592002947 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 216592002948 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216592002949 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592002950 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 3.6e-84 216592002951 PS01051 Bacterial regulatory proteins, iclR family signature. 216592002952 glyoxylate carboligase; Provisional; Region: PRK11269 216592002953 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216592002954 PYR/PP interface [polypeptide binding]; other site 216592002955 dimer interface [polypeptide binding]; other site 216592002956 TPP binding site [chemical binding]; other site 216592002957 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216592002958 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 216592002959 TPP-binding site [chemical binding]; other site 216592002960 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 5.2e-55 216592002961 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 3.2e-37 216592002962 hydroxypyruvate isomerase; Provisional; Region: PRK09997 216592002963 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 3.1e-51 216592002964 tartronate semialdehyde reductase; Provisional; Region: PRK15059 216592002965 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216592002966 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 7.2e-07 216592002967 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 216592002968 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 216592002969 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 216592002970 Na binding site [ion binding]; other site 216592002971 substrate binding site [chemical binding]; other site 216592002972 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 3.7e-184 216592002973 12 probable transmembrane helices predicted for EC042_0554 by TMHMM2.0 at aa 51-73, 88-110, 117-139, 154-176, 189-211, 226-248, 268-290, 310-332, 345-367, 377-399, 420-439 and 449-468 216592002974 allantoinase; Provisional; Region: PRK08044 216592002975 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 216592002976 active site 216592002977 HMMPfam hit to PF01979, Amidohydrolase family, score 2e-10 216592002978 putative uracil/xanthine transporter; Provisional; Region: PRK11412 216592002979 PS00430 TonB-dependent receptor proteins signature 1. 216592002980 HMMPfam hit to PF00860, Permease family, score 2.6e-128 216592002981 13 probable transmembrane helices predicted for EC042_0556 by TMHMM2.0 at aa 13-35, 45-67, 79-98, 102-124, 131-153, 173-192, 199-216, 231-253, 283-305, 320-342, 349-368, 383-400 and 407-429 216592002982 glycerate kinase II; Provisional; Region: PRK09932 216592002983 HMMPfam hit to PF02595, Glycerate kinase family, score 5.5e-282 216592002984 PS00017 ATP/GTP-binding site motif A (P-loop). 216592002985 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 216592002986 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 216592002987 Cupin domain; Region: Cupin_2; cl17218 216592002988 HMMPfam hit to PF06038, Protein of unknown function (DUF923), score 4.2e-175 216592002989 allantoate amidohydrolase; Region: AllC; TIGR03176 216592002990 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216592002991 active site 216592002992 metal binding site [ion binding]; metal-binding site 216592002993 dimer interface [polypeptide binding]; other site 216592002994 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 3e-33 216592002995 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.0049 216592002996 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 216592002997 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 2.2e-212 216592002998 membrane protein FdrA; Validated; Region: PRK06091 216592002999 CoA binding domain; Region: CoA_binding; pfam02629 216592003000 CoA-ligase; Region: Ligase_CoA; pfam00549 216592003001 HMMPfam hit to PF06263, Bacterial FdrA protein, score 0 216592003002 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 216592003003 HMMPfam hit to PF06545, Protein of unknown function (DUF1116), score 0 216592003004 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 216592003005 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 216592003006 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 216592003007 putative substrate binding site [chemical binding]; other site 216592003008 nucleotide binding site [chemical binding]; other site 216592003009 nucleotide binding site [chemical binding]; other site 216592003010 homodimer interface [polypeptide binding]; other site 216592003011 HMMPfam hit to PF00696, Amino acid kinase family, score 8.7e-89 216592003012 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 216592003013 ATP-grasp domain; Region: ATP-grasp; pfam02222 216592003014 HMMPfam hit to PF02222, ATP-grasp domain, score 4.5e-28 216592003015 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 216592003016 HMMPfam hit to PF00731, AIR carboxylase, score 6.8e-109 216592003017 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216592003018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216592003019 putative active site [active] 216592003020 putative metal binding site [ion binding]; other site 216592003021 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.1e-15 216592003022 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 216592003023 substrate binding site [chemical binding]; other site 216592003024 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 1.3e-55 216592003025 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 216592003026 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 216592003027 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216592003028 active site 216592003029 HIGH motif; other site 216592003030 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216592003031 KMSKS motif; other site 216592003032 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 216592003033 tRNA binding surface [nucleotide binding]; other site 216592003034 anticodon binding site; other site 216592003035 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 2.5e-226 216592003036 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 216592003037 4 probable transmembrane helices predicted for EC042_0570 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 148-170 216592003038 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 3.4e-34 216592003039 ribosome-associated protein; Provisional; Region: PRK11507 216592003040 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 216592003041 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216592003042 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216592003043 homodimer interface [polypeptide binding]; other site 216592003044 NADP binding site [chemical binding]; other site 216592003045 substrate binding site [chemical binding]; other site 216592003046 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 1.5e-104 216592003047 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 216592003048 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 1.1e-71 216592003049 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 216592003050 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003051 Fimbrial operon 4. Present in 0157, absent in Uropathogenic. 216592003052 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 216592003053 Signal peptide predicted for EC042_0573 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.969 between residues 33 and 34 216592003054 1 probable transmembrane helix predicted for EC042_0573 by TMHMM2.0 at aa 13-35 216592003055 HMMPfam hit to PF00419, Fimbrial protein, score 2.5e-57 216592003056 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 216592003057 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592003058 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592003059 Signal peptide predicted for EC042_0574 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 216592003060 1 probable transmembrane helix predicted for EC042_0574 by TMHMM2.0 at aa 7-29 216592003061 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 7.8e-57 216592003062 PS00635 Gram-negative pili assembly chaperone signature. 216592003063 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 3.3e-20 216592003064 outer membrane usher protein FimD; Provisional; Region: PRK15198 216592003065 PapC N-terminal domain; Region: PapC_N; pfam13954 216592003066 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592003067 PapC C-terminal domain; Region: PapC_C; pfam13953 216592003068 Signal peptide predicted for EC042_0575 by SignalP 2.0 HMM (Signal peptide probability 0.849) with cleavage site probability 0.835 between residues 35 and 36 216592003069 1 probable transmembrane helix predicted for EC042_0575 by TMHMM2.0 at aa 13-35 216592003070 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592003071 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592003072 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592003073 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 216592003074 Signal peptide predicted for EC042_0576 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.571 between residues 22 and 23 216592003075 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 216592003076 Signal peptide predicted for EC042_0577 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 216592003077 HMMPfam hit to PF00419, Fimbrial protein, score 5.3e-39 216592003078 transcriptional regulator FimZ; Provisional; Region: PRK09935 216592003079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592003080 active site 216592003081 phosphorylation site [posttranslational modification] 216592003082 intermolecular recognition site; other site 216592003083 dimerization interface [polypeptide binding]; other site 216592003084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592003085 DNA binding residues [nucleotide binding] 216592003086 dimerization interface [polypeptide binding]; other site 216592003087 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 4.4e-29 216592003088 PS00622 Bacterial regulatory proteins, luxR family signature. 216592003089 Predicted helix-turn-helix motif with score 1338.000, SD 3.74 at aa 174-195, sequence LSNKEIADKLLLSNKTVSAHKS 216592003090 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.9e-36 216592003091 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216592003092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592003093 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-12 216592003094 PS00041 Bacterial regulatory proteins, araC family signature. 216592003095 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.1e-06 216592003096 Predicted helix-turn-helix motif with score 1155.000, SD 3.12 at aa 163-184, sequence WNLRIVASSLCLSPSLLKKKLK 216592003097 hypothetical protein; Provisional; Region: PRK09936 216592003098 1 probable transmembrane helix predicted for EC042_0580 by TMHMM2.0 at aa 4-26 216592003099 Signal peptide predicted for EC042_0580 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.966 between residues 20 and 21 216592003100 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 216592003101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592003102 TPR motif; other site 216592003103 binding surface 216592003104 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 216592003105 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003106 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.4 216592003107 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2.2e-05 216592003108 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 3.4 216592003109 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003110 Signal peptide predicted for EC042_0581 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28 216592003111 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 216592003112 active site 216592003113 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 216592003114 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 216592003115 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 1.6e-36 216592003116 4 probable transmembrane helices predicted for EC042_0582 by TMHMM2.0 at aa 20-42, 361-383, 393-415 and 422-444 216592003117 Absent in Uropathogenic, divergent in 0157, hypothetical proteins and transposase. 0157 has RHS-type protein in equivalent region 216592003118 6 probable transmembrane helices predicted for EC042_0583 by TMHMM2.0 at aa 16-38, 48-70, 77-99, 103-122, 131-153 and 158-175 216592003119 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 216592003120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216592003121 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592003122 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592003123 HMMPfam hit to PF01609, Transposase DDE domain, score 8.3e-49 216592003124 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 216592003125 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 216592003126 this CDS is disrupted by the insertion of an IS element 216592003127 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 216592003128 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 216592003129 HMMPfam hit to PF03400, IS1 transposase, score 5.9e-113 216592003130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592003131 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592003132 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592003133 HMMPfam hit to PF03811, Insertion element protein, score 5.7e-69 216592003134 Predicted helix-turn-helix motif with score 1462.000, SD 4.17 at aa 64-85, sequence VGCRATARIMGVGLNTIFRHLK 216592003135 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003136 HMMPfam hit to PF01609, Transposase DDE domain, score 0.00011 216592003137 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003138 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 216592003139 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 216592003140 sensor kinase CusS; Provisional; Region: PRK09835 216592003141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592003142 dimerization interface [polypeptide binding]; other site 216592003143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592003144 dimer interface [polypeptide binding]; other site 216592003145 phosphorylation site [posttranslational modification] 216592003146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592003147 ATP binding site [chemical binding]; other site 216592003148 G-X-G motif; other site 216592003149 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.2e-40 216592003150 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.6e-16 216592003151 HMMPfam hit to PF00672, HAMP domain, score 5.2e-13 216592003152 2 probable transmembrane helices predicted for EC042_0604 by TMHMM2.0 at aa 21-43 and 191-210 216592003153 Signal peptide predicted for EC042_0604 by SignalP 2.0 HMM (Signal peptide probability 0.963) with cleavage site probability 0.779 between residues 36 and 37 216592003154 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 216592003155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592003156 active site 216592003157 phosphorylation site [posttranslational modification] 216592003158 intermolecular recognition site; other site 216592003159 dimerization interface [polypeptide binding]; other site 216592003160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592003161 DNA binding site [nucleotide binding] 216592003162 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.1e-24 216592003163 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.2e-39 216592003164 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 216592003165 Signal peptide predicted for EC042_0606 by SignalP 2.0 HMM (Signal peptide probability 0.873) with cleavage site probability 0.777 between residues 21 and 22 216592003166 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003167 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.5e-43 216592003168 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.2e-62 216592003169 periplasmic copper-binding protein; Provisional; Region: PRK09838 216592003170 Signal peptide predicted for EC042_0607 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.987 between residues 22 and 23 216592003171 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 216592003172 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592003173 Signal peptide predicted for EC042_0608 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.890 between residues 19 and 20 216592003174 1 probable transmembrane helix predicted for EC042_0608 by TMHMM2.0 at aa 7-26 216592003175 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 216592003176 Signal peptide predicted for EC042_0609 by SignalP 2.0 HMM (Signal peptide probability 0.782) with cleavage site probability 0.620 between residues 38 and 39 216592003177 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592003178 12 probable transmembrane helices predicted for EC042_0609 by TMHMM2.0 at aa 13-32, 342-359, 364-386, 390-412, 446-468, 483-505, 532-554, 874-891, 898-920, 924-946, 985-1002 and 1012-1034 216592003179 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592003180 phenylalanine transporter; Provisional; Region: PRK10249 216592003181 HMMPfam hit to PF00324, Amino acid permease, score 3.6e-112 216592003182 10 probable transmembrane helices predicted for EC042_0610 by TMHMM2.0 at aa 42-61, 65-82, 110-132, 147-169, 174-196, 218-240, 261-283, 303-325, 352-374 and 379-401 216592003183 PS00218 Amino acid permeases signature. 216592003184 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216592003185 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216592003186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592003187 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 5.8e-63 216592003188 5 probable transmembrane helices predicted for EC042_0611 by TMHMM2.0 at aa 23-45, 68-90, 105-127, 140-162 and 172-194 216592003189 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 216592003190 dimer interface [polypeptide binding]; other site 216592003191 FMN binding site [chemical binding]; other site 216592003192 HMMPfam hit to PF00881, Nitroreductase family, score 5.2e-76 216592003193 hypothetical protein; Provisional; Region: PRK10250 216592003194 HMMPfam hit to PF04237, Protein of unknown function (DUF419), score 3.3e-56 216592003195 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 216592003196 HMMPfam hit to PF06643, Protein of unknown function (DUF1158), score 1.4e-61 216592003197 2 probable transmembrane helices predicted for EC042_0614 by TMHMM2.0 at aa 13-35 and 50-72 216592003198 Signal peptide predicted for EC042_0614 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.965 between residues 31 and 32 216592003199 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003200 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 216592003201 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 216592003202 HMMPfam hit to PF04107, Glutamate-cysteine ligase family 2(GCS2), score 5.6e-129 216592003203 Hok/gef family; Region: HOK_GEF; pfam01848 216592003204 HMMPfam hit to PF01848, Hok/gef family, score 8.9e-30 216592003205 1 probable transmembrane helix predicted for EC042_0617 by TMHMM2.0 at aa 15-37 216592003206 PS00556 Hok/gef family cell toxic proteins signature. 216592003207 Hok/gef family; Region: HOK_GEF; pfam01848 216592003208 HMMPfam hit to PF01848, Hok/gef family, score 8.9e-30 216592003209 1 probable transmembrane helix predicted for EC042_0619 by TMHMM2.0 at aa 53-72 216592003210 PS00556 Hok/gef family cell toxic proteins signature. 216592003211 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 216592003212 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 216592003213 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 8.9e-11 216592003214 outer membrane receptor FepA; Provisional; Region: PRK13524 216592003215 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592003216 N-terminal plug; other site 216592003217 ligand-binding site [chemical binding]; other site 216592003218 HMMPfam hit to PF00593, TonB dependent receptor, score 3.5e-32 216592003219 PS01156 TonB-dependent receptor proteins signature 2. 216592003220 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.1e-29 216592003221 PS00430 TonB-dependent receptor proteins signature 1. 216592003222 Signal peptide predicted for EC042_0621 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.998 between residues 22 and 23 216592003223 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 216592003224 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 216592003225 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 216592003226 HMMPfam hit to PF00756, Putative esterase, score 2.3e-87 216592003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 216592003228 HMMPfam hit to PF03621, MbtH-like protein, score 1.4e-37 216592003229 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 216592003230 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216592003231 acyl-activating enzyme (AAE) consensus motif; other site 216592003232 AMP binding site [chemical binding]; other site 216592003233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592003234 HMMPfam hit to PF00668, Condensation domain, score 3.4e-78 216592003235 HMMPfam hit to PF00501, AMP-binding enzyme, score 3e-161 216592003236 PS00455 Putative AMP-binding domain signature. 216592003237 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 4.8e-11 216592003238 PS00012 Phosphopantetheine attachment site. 216592003239 HMMPfam hit to PF00975, Thioesterase domain, score 5.7e-54 216592003240 LPS O-antigen length regulator; Provisional; Region: PRK10381 216592003241 Chain length determinant protein; Region: Wzz; pfam02706 216592003242 HMMPfam hit to PF02706, Chain length determinant protein, score 1.9e-31 216592003243 2 probable transmembrane helices predicted for EC042_0625 by TMHMM2.0 at aa 43-62 and 340-359 216592003244 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 216592003245 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592003246 Walker A/P-loop; other site 216592003247 ATP binding site [chemical binding]; other site 216592003248 Q-loop/lid; other site 216592003249 ABC transporter signature motif; other site 216592003250 Walker B; other site 216592003251 D-loop; other site 216592003252 H-loop/switch region; other site 216592003253 HMMPfam hit to PF00005, ABC transporter, score 2.7e-55 216592003254 PS00211 ABC transporters family signature. 216592003255 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003256 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 216592003257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592003258 ABC-ATPase subunit interface; other site 216592003259 dimer interface [polypeptide binding]; other site 216592003260 putative PBP binding regions; other site 216592003261 HMMPfam hit to PF01032, FecCD transport family, score 3.2e-127 216592003262 8 probable transmembrane helices predicted for EC042_0627 by TMHMM2.0 at aa 7-29, 58-80, 93-112, 116-138, 145-167, 187-209, 240-262 and 302-324 216592003263 Signal peptide predicted for EC042_0627 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.804 between residues 22 and 23 216592003264 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592003265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592003266 ABC-ATPase subunit interface; other site 216592003267 dimer interface [polypeptide binding]; other site 216592003268 putative PBP binding regions; other site 216592003269 HMMPfam hit to PF01032, FecCD transport family, score 6.9e-134 216592003270 9 probable transmembrane helices predicted for EC042_0628 by TMHMM2.0 at aa 15-34, 69-88, 98-120, 125-144, 154-176, 197-219, 244-266, 286-308 and 312-330 216592003271 Signal peptide predicted for EC042_0628 by SignalP 2.0 HMM (Signal peptide probability 0.751) with cleavage site probability 0.267 between residues 36 and 37 216592003272 enterobactin exporter EntS; Provisional; Region: PRK10489 216592003273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592003274 putative substrate translocation pore; other site 216592003275 Signal peptide predicted for EC042_0629 by SignalP 2.0 HMM (Signal peptide probability 0.865) with cleavage site probability 0.717 between residues 20 and 21 216592003276 11 probable transmembrane helices predicted for EC042_0629 by TMHMM2.0 at aa 20-42, 54-76, 86-104, 111-133, 148-170, 177-199, 214-236, 256-278, 288-307, 314-336 and 377-399 216592003277 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.8e-22 216592003278 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 216592003279 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216592003280 siderophore binding site; other site 216592003281 HMMPfam hit to PF01497, Periplasmic binding protein, score 3e-63 216592003282 Signal peptide predicted for EC042_0630 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 26 and 27 216592003283 isochorismate synthase EntC; Provisional; Region: PRK15016 216592003284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216592003285 HMMPfam hit to PF00425, chorismate binding enzyme, score 7e-123 216592003286 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 216592003287 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 216592003288 acyl-activating enzyme (AAE) consensus motif; other site 216592003289 active site 216592003290 AMP binding site [chemical binding]; other site 216592003291 substrate binding site [chemical binding]; other site 216592003292 HMMPfam hit to PF00501, AMP-binding enzyme, score 3e-107 216592003293 PS00455 Putative AMP-binding domain signature. 216592003294 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 216592003295 hydrophobic substrate binding pocket; other site 216592003296 Isochorismatase family; Region: Isochorismatase; pfam00857 216592003297 active site 216592003298 conserved cis-peptide bond; other site 216592003299 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 216592003300 HMMPfam hit to PF00857, Isochorismatase family, score 1.9e-104 216592003301 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 5.5e-13 216592003302 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 216592003303 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 216592003304 putative NAD(P) binding site [chemical binding]; other site 216592003305 active site 216592003306 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.1e-64 216592003307 PS00061 Short-chain dehydrogenases/reductases family signature. 216592003308 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216592003309 CoenzymeA binding site [chemical binding]; other site 216592003310 subunit interaction site [polypeptide binding]; other site 216592003311 PHB binding site; other site 216592003312 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.1e-17 216592003313 carbon starvation protein A; Provisional; Region: PRK15015 216592003314 Carbon starvation protein CstA; Region: CstA; pfam02554 216592003315 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 216592003316 Signal peptide predicted for EC042_0636 by SignalP 2.0 HMM (Signal peptide probability 0.900) with cleavage site probability 0.562 between residues 22 and 23 216592003317 18 probable transmembrane helices predicted for EC042_0636 by TMHMM2.0 at aa 7-26, 32-54, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 326-348, 361-383, 398-420, 441-463, 468-487, 514-533, 548-570, 577-599 and 649-671 216592003318 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 1.3e-297 216592003319 Uncharacterized small protein [Function unknown]; Region: COG2879 216592003320 HMMPfam hit to PF04328, Protein of unknown function (DUF466), score 8.4e-47 216592003321 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 216592003322 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 216592003323 putative active site [active] 216592003324 metal binding site [ion binding]; metal-binding site 216592003325 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 6.3e-12 216592003326 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592003327 methionine aminotransferase; Validated; Region: PRK09082 216592003328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592003329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592003330 homodimer interface [polypeptide binding]; other site 216592003331 catalytic residue [active] 216592003332 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5.7e-20 216592003333 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003334 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216592003335 ParB-like nuclease domain; Region: ParBc; pfam02195 216592003336 HMMPfam hit to PF02195, ParB-like nuclease domain, score 9.6e-21 216592003337 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 216592003338 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592003339 Active Sites [active] 216592003340 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 216592003341 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 216592003342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592003343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592003344 dimerization interface [polypeptide binding]; other site 216592003345 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 1.2e-21 216592003346 PS00044 Bacterial regulatory proteins, lysR family signature. 216592003347 Predicted helix-turn-helix motif with score 1733.000, SD 5.09 at aa 37-58, sequence LSISKAAESLYITPSAVSQSLQ 216592003348 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 216592003349 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 216592003350 dimerization domain [polypeptide binding]; other site 216592003351 dimer interface [polypeptide binding]; other site 216592003352 catalytic residues [active] 216592003353 Signal peptide predicted for EC042_0643 by SignalP 2.0 HMM (Signal peptide probability 0.956) with cleavage site probability 0.956 between residues 17 and 18 216592003354 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 216592003355 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 216592003356 dimer interface [polypeptide binding]; other site 216592003357 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216592003358 catalytic triad [active] 216592003359 peroxidatic and resolving cysteines [active] 216592003360 HMMPfam hit to PF00578, AhpC/TSA family, score 5.4e-68 216592003361 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 216592003362 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 216592003363 catalytic residue [active] 216592003364 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 216592003365 catalytic residues [active] 216592003366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592003367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592003368 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 3.4e-71 216592003369 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 216592003370 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592003371 Ligand Binding Site [chemical binding]; other site 216592003372 HMMPfam hit to PF00582, Universal stress protein family, score 1.3e-16 216592003373 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 216592003374 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216592003375 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 216592003376 B1 nucleotide binding pocket [chemical binding]; other site 216592003377 B2 nucleotide binding pocket [chemical binding]; other site 216592003378 CAS motifs; other site 216592003379 active site 216592003380 HMMPfam hit to PF00445, Ribonuclease T2 family, score 5.8e-05 216592003381 PS00531 Ribonuclease T2 family histidine active site 2. 216592003382 PS00530 Ribonuclease T2 family histidine active site 1. 216592003383 Signal peptide predicted for EC042_0648 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.567 between residues 29 and 30 216592003384 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216592003385 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 216592003386 transmembrane helices; other site 216592003387 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 3.9e-295 216592003388 13 probable transmembrane helices predicted for EC042_0649 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117, 138-157, 198-220, 233-255, 288-305, 307-329, 339-361, 374-396, 428-450 and 463-485 216592003389 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 216592003390 HMMPfam hit to PF01874, ATP:dephospho-CoA triphosphoribosyl transfer, score 2.4e-148 216592003391 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 216592003392 HMMPfam hit to PF03802, Apo-citrate lyase phosphoribosyl-dephospho-C, score 3.6e-110 216592003393 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003394 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 216592003395 HMMPfam hit to PF04223, Citrate lyase, alpha subunit (CitF), score 0 216592003396 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592003397 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216592003398 HMMPfam hit to PF03328, HpcH/HpaI aldolase/citrate lyase family, score 2.9e-119 216592003399 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 216592003400 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 216592003401 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 216592003402 putative active site [active] 216592003403 (T/H)XGH motif; other site 216592003404 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7e-05 216592003405 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 216592003406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592003407 putative active site [active] 216592003408 heme pocket [chemical binding]; other site 216592003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592003410 ATP binding site [chemical binding]; other site 216592003411 Mg2+ binding site [ion binding]; other site 216592003412 G-X-G motif; other site 216592003413 Signal peptide predicted for EC042_0655 by SignalP 2.0 HMM (Signal peptide probability 0.700) with cleavage site probability 0.612 between residues 38 and 39 216592003414 2 probable transmembrane helices predicted for EC042_0655 by TMHMM2.0 at aa 40-62 and 200-222 216592003415 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8.6e-27 216592003416 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 216592003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592003418 active site 216592003419 phosphorylation site [posttranslational modification] 216592003420 intermolecular recognition site; other site 216592003421 dimerization interface [polypeptide binding]; other site 216592003422 Transcriptional regulator; Region: CitT; pfam12431 216592003423 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.5e-23 216592003424 Predicted helix-turn-helix motif with score 1402.000, SD 3.96 at aa 178-199, sequence HTAETVAQALTISRTTARRYLE 216592003425 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 216592003426 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 216592003427 12 probable transmembrane helices predicted for EC042_0657 by TMHMM2.0 at aa 4-22, 29-46, 81-103, 124-146, 161-183, 196-218, 238-260, 267-289, 309-331, 343-365, 407-429 and 436-458 216592003428 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.8e-208 216592003429 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 216592003430 2 probable transmembrane helices predicted for EC042_0658 by TMHMM2.0 at aa 15-34 and 154-176 216592003431 HMMPfam hit to PF07017, Antimicrobial peptide resistance and lipid A, score 4.9e-124 216592003432 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592003433 DNA-binding site [nucleotide binding]; DNA binding site 216592003434 RNA-binding motif; other site 216592003435 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 5.6e-44 216592003436 PS00352 'Cold-shock' DNA-binding domain signature. 216592003437 chromosome condensation membrane protein; Provisional; Region: PRK14196 216592003438 HMMPfam hit to PF02537, CrcB-like protein, score 3.1e-59 216592003439 4 probable transmembrane helices predicted for EC042_0660 by TMHMM2.0 at aa 4-23, 32-54, 69-91 and 98-120 216592003440 Signal peptide predicted for EC042_0660 by SignalP 2.0 HMM (Signal peptide probability 0.622) with cleavage site probability 0.447 between residues 18 and 19 216592003441 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216592003442 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 216592003443 putative active site [active] 216592003444 catalytic triad [active] 216592003445 putative dimer interface [polypeptide binding]; other site 216592003446 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 2.3e-24 216592003447 PS01227 Uncharacterized protein family UPF0012 signature. 216592003448 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 216592003449 HMMPfam hit to PF02416, mttA/Hcf106 family, score 6.6e-08 216592003450 1 probable transmembrane helix predicted for EC042_0662 by TMHMM2.0 at aa 4-21 216592003451 lipoyl synthase; Provisional; Region: PRK05481 216592003452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592003453 FeS/SAM binding site; other site 216592003454 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.5e-23 216592003455 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 216592003456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592003457 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 216592003458 substrate binding pocket [chemical binding]; other site 216592003459 dimerization interface [polypeptide binding]; other site 216592003460 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.6e-18 216592003461 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.9e-16 216592003462 PS00044 Bacterial regulatory proteins, lysR family signature. 216592003463 Predicted helix-turn-helix motif with score 1319.000, SD 3.68 at aa 44-65, sequence KGIVNAAKVLNLTPSAISQSIQ 216592003464 lipoate-protein ligase B; Provisional; Region: PRK14342 216592003465 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 1.3e-34 216592003466 PS01313 Lipoate-protein ligase B signature. 216592003467 hypothetical protein; Provisional; Region: PRK04998 216592003468 HMMPfam hit to PF04359, Protein of unknown function (DUF493), score 2.3e-55 216592003469 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 216592003470 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216592003471 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 216592003472 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 9.2e-152 216592003473 Signal peptide predicted for EC042_0667 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 29 and 30 216592003474 rare lipoprotein A; Provisional; Region: PRK10672 216592003475 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 216592003476 Sporulation related domain; Region: SPOR; pfam05036 216592003477 HMMPfam hit to PF05036, Sporulation related repeat, score 5.7e-09 216592003478 HMMPfam hit to PF05036, Sporulation related repeat, score 1.5e-08 216592003479 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 2.6e-27 216592003480 Signal peptide predicted for EC042_0668 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.641 between residues 23 and 24 216592003481 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003482 cell wall shape-determining protein; Provisional; Region: PRK10794 216592003483 HMMPfam hit to PF01098, Cell cycle protein, score 1.4e-183 216592003484 9 probable transmembrane helices predicted for EC042_0669 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360 216592003485 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 216592003486 Signal peptide predicted for EC042_0669 by SignalP 2.0 HMM (Signal peptide probability 0.912) with cleavage site probability 0.555 between residues 40 and 41 216592003487 penicillin-binding protein 2; Provisional; Region: PRK10795 216592003488 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216592003489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216592003490 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 3.7e-106 216592003491 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 5.1e-70 216592003492 1 probable transmembrane helix predicted for EC042_0670 by TMHMM2.0 at aa 21-43 216592003493 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 216592003494 HMMPfam hit to PF02590, Uncharacterized ACR, COG1576, score 7.3e-83 216592003495 ribosome-associated protein; Provisional; Region: PRK11538 216592003496 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 2.6e-54 216592003497 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003498 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216592003499 catalytic core [active] 216592003500 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 3.1e-90 216592003501 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 216592003502 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 216592003503 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 216592003504 active site 216592003505 (T/H)XGH motif; other site 216592003506 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.3e-65 216592003507 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 216592003508 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 216592003509 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 1.2e-136 216592003510 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 216592003511 HMMPfam hit to PF04390, Rare lipoprotein B family, score 3.2e-89 216592003512 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003513 Signal peptide predicted for EC042_0676 by SignalP 2.0 HMM (Signal peptide probability 0.719) with cleavage site probability 0.403 between residues 18 and 19 216592003514 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 216592003515 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 216592003516 HIGH motif; other site 216592003517 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216592003518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216592003519 active site 216592003520 KMSKS motif; other site 216592003521 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216592003522 tRNA binding surface [nucleotide binding]; other site 216592003523 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216592003524 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 8.2e-301 216592003525 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592003526 hypothetical protein; Provisional; Region: PRK11032 216592003527 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 216592003528 HMMPfam hit to PF07295, Protein of unknown function (DUF1451), score 1.3e-107 216592003529 Present in 0157, absent in Uropathogenic, hypothetical protein and Hsp70-like protein 216592003530 Sel1-like repeats; Region: SEL1; smart00671 216592003531 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216592003532 Sel1-like repeats; Region: SEL1; smart00671 216592003533 Sel1-like repeats; Region: SEL1; smart00671 216592003534 Sel1-like repeats; Region: SEL1; smart00671 216592003535 Sel1-like repeats; Region: SEL1; smart00671 216592003536 Sel1-like repeats; Region: SEL1; smart00671 216592003537 Sel1-like repeats; Region: SEL1; smart00671 216592003538 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 216592003539 HMMPfam hit to PF06889, Protein of unknown function (DUF1266), score 3.2e-193 216592003540 DnaJ domain; Region: DnaJ; pfam00226 216592003541 HSP70 interaction site [polypeptide binding]; other site 216592003542 HMMPfam hit to PF00226, DnaJ domain, score 0.00028 216592003543 1 probable transmembrane helix predicted for EC042_0681 by TMHMM2.0 at aa 398-420 216592003544 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216592003545 Sel1-like repeats; Region: SEL1; smart00671 216592003546 Sel1-like repeats; Region: SEL1; smart00671 216592003547 Sel1-like repeats; Region: SEL1; smart00671 216592003548 1 probable transmembrane helix predicted for EC042_0682 by TMHMM2.0 at aa 5-22 216592003549 Signal peptide predicted for EC042_0682 by SignalP 2.0 HMM (Signal peptide probability 0.776) with cleavage site probability 0.533 between residues 21 and 22 216592003550 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 216592003551 HMMPfam hit to PF06889, Protein of unknown function (DUF1266), score 1.8e-199 216592003552 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 216592003553 HMMPfam hit to PF00226, DnaJ domain, score 0.0038 216592003554 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 216592003555 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 216592003556 nucleotide binding site [chemical binding]; other site 216592003557 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216592003558 SBD interface [polypeptide binding]; other site 216592003559 HMMPfam hit to PF00012, Hsp70 protein, score 5.5e-92 216592003560 PS01036 Heat shock hsp70 proteins family signature 3. 216592003561 PS00329 Heat shock hsp70 proteins family signature 2. 216592003562 PS00297 Heat shock hsp70 proteins family signature 1. 216592003563 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216592003564 active site 216592003565 tetramer interface [polypeptide binding]; other site 216592003566 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 4.4e-194 216592003567 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 216592003568 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216592003569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216592003570 Walker A/P-loop; other site 216592003571 ATP binding site [chemical binding]; other site 216592003572 Q-loop/lid; other site 216592003573 ABC transporter signature motif; other site 216592003574 Walker B; other site 216592003575 D-loop; other site 216592003576 H-loop/switch region; other site 216592003577 HMMPfam hit to PF00005, ABC transporter, score 5.4e-66 216592003578 PS00211 ABC transporters family signature. 216592003579 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003580 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592003581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592003582 dimer interface [polypeptide binding]; other site 216592003583 conserved gate region; other site 216592003584 putative PBP binding loops; other site 216592003585 ABC-ATPase subunit interface; other site 216592003586 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.5e-32 216592003587 5 probable transmembrane helices predicted for EC042_0688 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 216592003588 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592003589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592003590 dimer interface [polypeptide binding]; other site 216592003591 conserved gate region; other site 216592003592 putative PBP binding loops; other site 216592003593 ABC-ATPase subunit interface; other site 216592003594 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.6e-41 216592003595 5 probable transmembrane helices predicted for EC042_0689 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233 216592003596 Predicted helix-turn-helix motif with score 1078.000, SD 2.86 at aa 139-160, sequence RGQKNAALAMGLTLPQAYRYVL 216592003597 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216592003598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592003599 substrate binding pocket [chemical binding]; other site 216592003600 membrane-bound complex binding site; other site 216592003601 hinge residues; other site 216592003602 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 2.1e-57 216592003603 Signal peptide predicted for EC042_0690 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 216592003604 Rhomboid family; Region: Rhomboid; pfam01694 216592003605 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 216592003606 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216592003607 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216592003608 7 probable transmembrane helices predicted for EC042_0691 by TMHMM2.0 at aa 13-35, 73-95, 100-122, 127-149, 162-181, 185-202 and 209-231 216592003609 HMMPfam hit to PF01694, Rhomboid family, score 9.4e-36 216592003610 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 216592003611 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216592003612 putative active site [active] 216592003613 catalytic triad [active] 216592003614 putative dimer interface [polypeptide binding]; other site 216592003615 6 probable transmembrane helices predicted for EC042_0692 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 166-188, 195-213 and 489-507 216592003616 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 2.5e-50 216592003617 Signal peptide predicted for EC042_0692 by SignalP 2.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.516 between residues 27 and 28 216592003618 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 216592003619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216592003620 Transporter associated domain; Region: CorC_HlyC; smart01091 216592003621 HMMPfam hit to PF03471, Transporter associated domain, score 1.2e-29 216592003622 HMMPfam hit to PF00571, CBS domain, score 1.6e-09 216592003623 HMMPfam hit to PF00571, CBS domain, score 9.6e-11 216592003624 metal-binding heat shock protein; Provisional; Region: PRK00016 216592003625 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 2.7e-53 216592003626 PS01306 Uncharacterized protein family UPF0054 signature. 216592003627 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216592003628 PhoH-like protein; Region: PhoH; pfam02562 216592003629 HMMPfam hit to PF02562, PhoH-like protein, score 2e-154 216592003630 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003631 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 216592003632 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216592003633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592003634 FeS/SAM binding site; other site 216592003635 TRAM domain; Region: TRAM; pfam01938 216592003636 HMMPfam hit to PF01938, TRAM domain, score 5.8e-25 216592003637 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.3e-33 216592003638 PS01278 Uncharacterized protein family UPF0004 signature. 216592003639 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 1.4e-50 216592003640 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 216592003641 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216592003642 1 probable transmembrane helix predicted for EC042_0697 by TMHMM2.0 at aa 7-29 216592003643 HMMPfam hit to PF01360, Monooxygenase, score 4.2e-42 216592003644 PS01304 ubiH/COQ6 monooxygenase family signature. 216592003646 Signal peptide predicted for EC042_0701 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 216592003647 asparagine synthetase B; Provisional; Region: asnB; PRK09431 216592003648 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216592003649 active site 216592003650 dimer interface [polypeptide binding]; other site 216592003651 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 216592003652 Ligand Binding Site [chemical binding]; other site 216592003653 Molecular Tunnel; other site 216592003654 HMMPfam hit to PF00733, Asparagine synthase, score 1.7e-111 216592003655 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2.1e-35 216592003656 PS00443 Glutamine amidotransferases class-II active site. 216592003657 UMP phosphatase; Provisional; Region: PRK10444 216592003658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592003659 active site 216592003660 motif I; other site 216592003661 motif II; other site 216592003662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592003663 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 7.6e-16 216592003664 MarR family; Region: MarR; pfam01047 216592003665 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216592003666 ROK family; Region: ROK; pfam00480 216592003667 HMMPfam hit to PF00480, ROK family, score 2.4e-92 216592003668 PS01125 ROK family signature. 216592003669 Predicted helix-turn-helix motif with score 1021.000, SD 2.66 at aa 33-54, sequence ISRIQIAEQSQLAPASVTKITR 216592003670 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 216592003671 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 216592003672 active site 216592003673 dimer interface [polypeptide binding]; other site 216592003674 HMMPfam hit to PF01979, Amidohydrolase family, score 5.4e-50 216592003675 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 216592003676 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 216592003677 active site 216592003678 trimer interface [polypeptide binding]; other site 216592003679 allosteric site; other site 216592003680 active site lid [active] 216592003681 hexamer (dimer of trimers) interface [polypeptide binding]; other site 216592003682 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 4.1e-198 216592003683 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 216592003684 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 216592003685 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 216592003686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592003687 active site turn [active] 216592003688 phosphorylation site [posttranslational modification] 216592003689 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 216592003690 HPr interaction site; other site 216592003691 glycerol kinase (GK) interaction site [polypeptide binding]; other site 216592003692 active site 216592003693 phosphorylation site [posttranslational modification] 216592003694 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.8e-100 216592003695 10 probable transmembrane helices predicted for EC042_0707 by TMHMM2.0 at aa 39-61, 68-90, 94-111, 132-151, 166-185, 192-214, 229-251, 258-280, 295-317 and 337-359 216592003696 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 9.5e-17 216592003697 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592003698 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 4.7e-69 216592003699 PS00371 PTS EIIA domains phosphorylation site signature 1. 216592003700 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 216592003701 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216592003702 active site 216592003703 HIGH motif; other site 216592003704 nucleotide binding site [chemical binding]; other site 216592003705 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 216592003706 KMSKS motif; other site 216592003707 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 216592003708 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), ca, score 1.1e-186 216592003709 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592003710 HMMPfam hit to PF03950, tRNA synthetases class I (E and Q), an, score 2e-110 216592003711 outer membrane porin, OprD family; Region: OprD; pfam03573 216592003712 Signal peptide predicted for EC042_0709 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.518 between residues 32 and 33 216592003713 YbfN-like lipoprotein; Region: YbfN; pfam13982 216592003714 Signal peptide predicted for EC042_0710 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.478 between residues 18 and 19 216592003715 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003716 ferric uptake regulator; Provisional; Region: fur; PRK09462 216592003717 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216592003718 metal binding site 2 [ion binding]; metal-binding site 216592003719 putative DNA binding helix; other site 216592003720 metal binding site 1 [ion binding]; metal-binding site 216592003721 dimer interface [polypeptide binding]; other site 216592003722 structural Zn2+ binding site [ion binding]; other site 216592003723 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.2e-74 216592003724 flavodoxin FldA; Validated; Region: PRK09267 216592003725 HMMPfam hit to PF00258, Flavodoxin, score 1.9e-54 216592003726 PS00201 Flavodoxin signature. 216592003727 LexA regulated protein; Provisional; Region: PRK11675 216592003728 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 1.3e-09 216592003729 acyl-CoA esterase; Provisional; Region: PRK10673 216592003730 PGAP1-like protein; Region: PGAP1; pfam07819 216592003731 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 6.8e-21 216592003732 replication initiation regulator SeqA; Provisional; Region: PRK11187 216592003733 HMMPfam hit to PF03925, SeqA protein, score 1.4e-149 216592003734 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 216592003735 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 216592003736 active site 216592003737 substrate binding site [chemical binding]; other site 216592003738 metal binding site [ion binding]; metal-binding site 216592003739 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 4e-39 216592003740 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216592003741 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 8.2e-18 216592003742 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.1e-28 216592003743 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 1.4e-13 216592003744 Signal peptide predicted for EC042_0717 by SignalP 2.0 HMM (Signal peptide probability 0.841) with cleavage site probability 0.550 between residues 29 and 30 216592003745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003746 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 216592003747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592003748 active site 216592003749 phosphorylation site [posttranslational modification] 216592003750 intermolecular recognition site; other site 216592003751 dimerization interface [polypeptide binding]; other site 216592003752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592003753 DNA binding site [nucleotide binding] 216592003754 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.6e-19 216592003755 HMMPfam hit to PF00072, Response regulator receiver domain, score 5e-46 216592003756 sensor protein KdpD; Provisional; Region: PRK10490 216592003757 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 216592003758 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 216592003759 Ligand Binding Site [chemical binding]; other site 216592003760 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 216592003761 GAF domain; Region: GAF_3; pfam13492 216592003762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592003763 dimer interface [polypeptide binding]; other site 216592003764 phosphorylation site [posttranslational modification] 216592003765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592003766 ATP binding site [chemical binding]; other site 216592003767 Mg2+ binding site [ion binding]; other site 216592003768 G-X-G motif; other site 216592003769 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.6e-37 216592003770 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-15 216592003771 4 probable transmembrane helices predicted for EC042_0719 by TMHMM2.0 at aa 400-422, 426-445, 450-472 and 477-499 216592003772 HMMPfam hit to PF00582, Universal stress protein family, score 9.3e-06 216592003773 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, score 2e-158 216592003774 PS00017 ATP/GTP-binding site motif A (P-loop). 216592003775 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 216592003776 HMMPfam hit to PF02669, K+-transporting ATPase, c chain, score 9.2e-145 216592003777 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 147-168, sequence WQIPRVAKARNLSVEQLTQLIA 216592003778 1 probable transmembrane helix predicted for EC042_0720 by TMHMM2.0 at aa 20-42 216592003779 Signal peptide predicted for EC042_0720 by SignalP 2.0 HMM (Signal peptide probability 0.733) with cleavage site probability 0.496 between residues 32 and 33 216592003780 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 216592003781 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216592003782 PS00294 Prenyl group binding site (CAAX box). 216592003783 7 probable transmembrane helices predicted for EC042_0721 by TMHMM2.0 at aa 36-58, 63-85, 220-242, 252-274, 578-600, 615-634 and 654-676 216592003784 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.1e-35 216592003785 PS00154 E1-E2 ATPases phosphorylation site. 216592003786 HMMPfam hit to PF00122, E1-E2 ATPase, score 5.8e-63 216592003787 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 216592003788 HMMPfam hit to PF03814, Potassium-transporting ATPase A subunit, score 0 216592003789 12 probable transmembrane helices predicted for EC042_0722 by TMHMM2.0 at aa 46-68, 110-132, 178-200, 221-243, 301-323, 330-349, 375-397, 402-424, 428-447, 464-486, 531-553 and 574-596 216592003790 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 216592003791 1 probable transmembrane helix predicted for EC042_0723 by TMHMM2.0 at aa 12-33 216592003792 hypothetical protein; Provisional; Region: PRK10167 216592003793 Uncharacterized conserved protein [Function unknown]; Region: COG3272 216592003794 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 216592003795 DNA photolyase; Region: DNA_photolyase; pfam00875 216592003796 HMMPfam hit to PF00875, DNA photolyase, score 8.6e-70 216592003797 PS00230 Neuraxin and MAP1B proteins repeated region signature. 216592003798 HMMPfam hit to PF03441, FAD binding domain of DNA photolyase, score 7.9e-160 216592003799 PS00394 DNA photolyases class 1 signature 1. 216592003800 PS00691 DNA photolyases class 1 signature 2. 216592003801 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 216592003802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592003803 putative substrate translocation pore; other site 216592003804 POT family; Region: PTR2; pfam00854 216592003805 14 probable transmembrane helices predicted for EC042_0726 by TMHMM2.0 at aa 13-35, 50-67, 72-94, 104-126, 139-161, 166-188, 209-231, 235-254, 267-284, 310-332, 344-366, 376-398, 410-432 and 462-479 216592003806 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-12 216592003807 HMMPfam hit to PF00854, POT family, score 7e-112 216592003808 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 216592003809 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592003810 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 216592003811 Uncharacterized conserved protein [Function unknown]; Region: COG0327 216592003812 metal-binding protein; Provisional; Region: PRK10799 216592003813 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 1.1e-116 216592003814 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 216592003815 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 216592003816 HMMPfam hit to PF02682, Allophanate hydrolase subunit, score 1.1e-141 216592003817 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 216592003818 HMMPfam hit to PF02626, Allophanate hydrolase subunit, score 1.6e-194 216592003819 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 216592003820 putative active site [active] 216592003821 HMMPfam hit to PF03746, LamB/YcsF family, score 8.7e-160 216592003822 endonuclease VIII; Provisional; Region: PRK10445 216592003823 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 216592003824 DNA binding site [nucleotide binding] 216592003825 catalytic residue [active] 216592003826 putative catalytic residues [active] 216592003827 H2TH interface [polypeptide binding]; other site 216592003828 intercalation triad [nucleotide binding]; other site 216592003829 substrate specificity determining residue; other site 216592003830 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216592003831 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216592003832 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 6.6e-47 216592003833 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 1.7e-33 216592003834 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 216592003835 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216592003836 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216592003837 HMMPfam hit to PF05145, Putative ammonia monooxygenase, score 3.2e-159 216592003838 10 probable transmembrane helices predicted for EC042_0732 by TMHMM2.0 at aa 28-50, 54-73, 80-102, 107-129, 164-186, 206-228, 248-270, 285-307, 314-333 and 343-365 216592003839 Fimbrial operon 5. Absent in Uropathogenic, divergent in 0157. 216592003840 Fimbrial protein; Region: Fimbrial; pfam00419 216592003841 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 216592003842 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592003843 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592003844 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1e-08 216592003845 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.6e-38 216592003846 PS00635 Gram-negative pili assembly chaperone signature. 216592003847 Signal peptide predicted for EC042_0734 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 22 and 23 216592003848 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216592003849 PapC N-terminal domain; Region: PapC_N; pfam13954 216592003850 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592003851 PapC C-terminal domain; Region: PapC_C; pfam13953 216592003852 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592003853 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592003854 Signal peptide predicted for EC042_0735 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.985 between residues 38 and 39 216592003855 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592003856 HMMPfam hit to PF00419, Fimbrial protein, score 1.8e-60 216592003857 Signal peptide predicted for EC042_0736 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 216592003858 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 216592003859 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 216592003860 dimer interface [polypeptide binding]; other site 216592003861 active site 216592003862 citrylCoA binding site [chemical binding]; other site 216592003863 NADH binding [chemical binding]; other site 216592003864 cationic pore residues; other site 216592003865 oxalacetate/citrate binding site [chemical binding]; other site 216592003866 coenzyme A binding site [chemical binding]; other site 216592003867 catalytic triad [active] 216592003868 HMMPfam hit to PF00285, Citrate synthase, score 1.9e-237 216592003869 PS00480 Citrate synthase signature. 216592003870 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 216592003871 Iron-sulfur protein interface; other site 216592003872 proximal quinone binding site [chemical binding]; other site 216592003873 SdhD (CybS) interface [polypeptide binding]; other site 216592003874 proximal heme binding site [chemical binding]; other site 216592003875 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 3.5e-45 216592003876 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 216592003877 3 probable transmembrane helices predicted for EC042_0739 by TMHMM2.0 at aa 32-54, 69-91 and 117-133 216592003878 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 216592003879 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 216592003880 SdhC subunit interface [polypeptide binding]; other site 216592003881 proximal heme binding site [chemical binding]; other site 216592003882 cardiolipin binding site; other site 216592003883 Iron-sulfur protein interface; other site 216592003884 proximal quinone binding site [chemical binding]; other site 216592003885 3 probable transmembrane helices predicted for EC042_0740 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 216592003886 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 216592003887 L-aspartate oxidase; Provisional; Region: PRK06175 216592003888 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216592003889 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 216592003890 HMMPfam hit to PF00890, FAD binding domain, score 2.2e-221 216592003891 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 6.5e-69 216592003892 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 216592003893 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216592003894 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592003895 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 216592003896 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 216592003897 TPP-binding site [chemical binding]; other site 216592003898 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 216592003899 dimer interface [polypeptide binding]; other site 216592003900 PYR/PP interface [polypeptide binding]; other site 216592003901 TPP binding site [chemical binding]; other site 216592003902 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592003903 HMMPfam hit to PF00676, Dehydrogenase E1 component, score 9.1e-29 216592003904 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 1.2e-75 216592003905 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 216592003906 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216592003907 E3 interaction surface; other site 216592003908 lipoyl attachment site [posttranslational modification]; other site 216592003909 e3 binding domain; Region: E3_binding; pfam02817 216592003910 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216592003911 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 2.3e-21 216592003912 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592003913 HMMPfam hit to PF02817, e3 binding domain, score 1.5e-17 216592003914 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 8.9e-142 216592003915 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 216592003916 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 216592003917 CoA-ligase; Region: Ligase_CoA; pfam00549 216592003918 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003919 HMMPfam hit to PF02222, ATP-grasp domain, score 1.2e-29 216592003920 HMMPfam hit to PF00549, CoA-ligase, score 7.1e-81 216592003921 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 216592003922 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 216592003923 CoA binding domain; Region: CoA_binding; smart00881 216592003924 CoA-ligase; Region: Ligase_CoA; pfam00549 216592003925 HMMPfam hit to PF02629, CoA binding domain, score 1.2e-67 216592003926 HMMPfam hit to PF00549, CoA-ligase, score 4.7e-62 216592003927 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 216592003928 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 216592003929 Present in 0157, absent in Uropathogenic, misc. metabolism (fermentation of glutamate?) (regulator, cob(I)yrinic acid a,c-diamide adenosyltransferase, fumarate hydratase, methylaspartate ammonia-lyase, methylaspartate mutase E chain, glutamate mutase, methylaspartate mutase S chain) 216592003930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592003931 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216592003932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592003933 dimerization interface [polypeptide binding]; other site 216592003934 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-14 216592003935 Predicted helix-turn-helix motif with score 1314.000, SD 3.66 at aa 21-42, sequence ESYTRAAEELALTQSAVFRQVS 216592003936 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.8e-24 216592003937 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 216592003938 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 216592003939 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 216592003940 homodimer interface [polypeptide binding]; other site 216592003941 Walker A motif; other site 216592003942 ATP binding site [chemical binding]; other site 216592003943 hydroxycobalamin binding site [chemical binding]; other site 216592003944 Walker B motif; other site 216592003945 HMMPfam hit to PF02572, ATP:corrinoid adenosyltransferase BtuR, score 9.7e-102 216592003946 putative fumarate hydratase; Provisional; Region: PRK15392 216592003947 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 216592003948 Fumarase C-terminus; Region: Fumerase_C; pfam05683 216592003949 HMMPfam hit to PF05683, Fumarase C-terminus, score 1.1e-113 216592003950 PS00163 Fumarate lyases signature. 216592003951 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 9.8e-134 216592003952 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216592003953 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 216592003954 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2e-101 216592003955 6 probable transmembrane helices predicted for EC042_0750 by TMHMM2.0 at aa 4-26, 46-68, 83-105, 155-177, 192-211 and 224-246 216592003956 Signal peptide predicted for EC042_0750 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.675 between residues 25 and 26 216592003957 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 216592003958 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 216592003959 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 216592003960 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 216592003961 dimer interface [polypeptide binding]; other site 216592003962 active site 216592003963 HMMPfam hit to PF07476, Methylaspartate ammonia-lyase C-terminus, score 2.5e-195 216592003964 HMMPfam hit to PF05034, Methylaspartate ammonia-lyase N-terminus, score 4.3e-123 216592003965 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 216592003966 substrate binding site [chemical binding]; other site 216592003967 B12 cofactor binding site [chemical binding]; other site 216592003968 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 216592003969 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 216592003970 HMMPfam hit to PF06368, Methylaspartate mutase E chain (MutE), score 0 216592003971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216592003972 conserved hypothetical protein; Region: glmL_fam; TIGR01319 216592003973 nucleotide binding site [chemical binding]; other site 216592003974 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 216592003975 B12 binding site [chemical binding]; other site 216592003976 heterodimer interface [polypeptide binding]; other site 216592003977 cobalt ligand [ion binding]; other site 216592003978 HMMPfam hit to PF02310, B12 binding domain, score 2.7e-14 216592003979 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 216592003980 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 216592003981 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 0 216592003982 9 probable transmembrane helices predicted for EC042_0759 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 131-153, 185-207, 220-239, 388-410, 422-444 and 472-494 216592003983 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 216592003984 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 216592003985 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 1.8e-233 216592003986 8 probable transmembrane helices predicted for EC042_0760 by TMHMM2.0 at aa 7-24, 77-99, 123-145, 160-182, 203-225, 262-281, 293-315 and 335-357 216592003987 hypothetical protein; Provisional; Region: PRK10588 216592003988 Signal peptide predicted for EC042_0761 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.844 between residues 40 and 41 216592003989 3 probable transmembrane helices predicted for EC042_0761 by TMHMM2.0 at aa 19-36, 46-68 and 73-95 216592003990 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592003991 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216592003992 active site 216592003993 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site. 216592003994 HMMPfam hit to PF03061, Thioesterase superfamily, score 1e-16 216592003995 colicin uptake protein TolQ; Provisional; Region: PRK10801 216592003996 3 probable transmembrane helices predicted for EC042_0763 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 216592003997 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.5e-64 216592003998 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 216592003999 colicin uptake protein TolR; Provisional; Region: PRK11024 216592004000 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 3.1e-14 216592004001 1 probable transmembrane helix predicted for EC042_0764 by TMHMM2.0 at aa 17-39 216592004002 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 216592004003 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 216592004004 TolA C-terminal; Region: TolA; pfam06519 216592004005 HMMPfam hit to PF06519, TolA protein, score 5.3e-209 216592004006 1 probable transmembrane helix predicted for EC042_0765 by TMHMM2.0 at aa 13-32 216592004007 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004008 translocation protein TolB; Provisional; Region: tolB; PRK03629 216592004009 TolB amino-terminal domain; Region: TolB_N; pfam04052 216592004010 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216592004011 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216592004012 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216592004013 Signal peptide predicted for EC042_0766 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.992 between residues 22 and 23 216592004014 HMMPfam hit to PF04052, TolB amino-terminal domain, score 1.4e-89 216592004015 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.44 216592004016 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 1.4e-06 216592004017 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2e-06 216592004018 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 3.1 216592004019 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.052 216592004020 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 216592004021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592004022 ligand binding site [chemical binding]; other site 216592004023 Signal peptide predicted for EC042_0767 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.718 between residues 28 and 29 216592004024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004025 HMMPfam hit to PF00691, OmpA family, score 2.7e-50 216592004026 PS01068 OmpA-like domain. 216592004027 tol-pal system protein YbgF; Provisional; Region: PRK10803 216592004028 Tetratricopeptide repeat; Region: TPR_6; pfam13174 216592004029 Tetratricopeptide repeat; Region: TPR_6; pfam13174 216592004030 Signal peptide predicted for EC042_0768 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 26 and 27 216592004031 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.003 216592004032 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0034 216592004033 quinolinate synthetase; Provisional; Region: PRK09375 216592004034 HMMPfam hit to PF02445, Quinolinate synthetase A protein, score 1.1e-199 216592004035 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 216592004036 HMMPfam hit to PF04973, Nicotinamide mononucleotide transport, score 5.4e-111 216592004037 6 probable transmembrane helices predicted for EC042_0771 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-132, 158-177 and 184-206 216592004038 zinc transporter ZitB; Provisional; Region: PRK03557 216592004039 HMMPfam hit to PF01545, Cation efflux family, score 4.6e-121 216592004040 PS00511 Corticotropin-releasing factor family signature. 216592004041 5 probable transmembrane helices predicted for EC042_0772 by TMHMM2.0 at aa 21-43, 53-71, 84-106, 121-143 and 164-183 216592004042 YbgS-like protein; Region: YbgS; pfam13985 216592004043 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592004044 Signal peptide predicted for EC042_0773 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 216592004045 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 216592004046 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216592004047 HMMPfam hit to PF00793, DAHP synthetase I family, score 1.9e-184 216592004048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216592004049 catalytic core [active] 216592004050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216592004051 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 2.8e-143 216592004052 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 216592004053 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 216592004054 active site 216592004055 catalytic residues [active] 216592004056 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.1e-132 216592004057 PS00545 Aldose 1-epimerase putative active site. 216592004058 galactokinase; Provisional; Region: PRK05101 216592004059 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 216592004060 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216592004061 HMMPfam hit to PF00288, GHMP kinases putative ATP-binding protei, score 2e-50 216592004062 PS00627 GHMP kinases putative ATP-binding domain. 216592004063 PS00106 Galactokinase signature. 216592004064 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 216592004065 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 216592004066 dimer interface [polypeptide binding]; other site 216592004067 active site 216592004068 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transfer, score 6.2e-107 216592004069 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transfer, score 2.9e-109 216592004070 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 216592004071 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 216592004072 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216592004073 NAD binding site [chemical binding]; other site 216592004074 homodimer interface [polypeptide binding]; other site 216592004075 active site 216592004076 substrate binding site [chemical binding]; other site 216592004077 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.4e-191 216592004078 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 216592004079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 216592004080 Walker A/P-loop; other site 216592004081 ATP binding site [chemical binding]; other site 216592004082 Q-loop/lid; other site 216592004083 ABC transporter signature motif; other site 216592004084 Walker B; other site 216592004085 D-loop; other site 216592004086 H-loop/switch region; other site 216592004087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592004088 Walker A/P-loop; other site 216592004089 ATP binding site [chemical binding]; other site 216592004090 Q-loop/lid; other site 216592004091 ABC transporter signature motif; other site 216592004092 Walker B; other site 216592004093 D-loop; other site 216592004094 H-loop/switch region; other site 216592004095 HMMPfam hit to PF00005, ABC transporter, score 3.9e-53 216592004096 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004097 PS00041 Bacterial regulatory proteins, araC family signature. 216592004098 HMMPfam hit to PF00005, ABC transporter, score 1.6e-20 216592004099 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004100 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 216592004101 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 216592004102 molybdenum-pterin binding domain; Region: Mop; TIGR00638 216592004103 TOBE domain; Region: TOBE; pfam03459 216592004104 HMMPfam hit to PF03459, TOBE domain, score 1.8e-11 216592004105 HMMPfam hit to PF03459, TOBE domain, score 8e-15 216592004106 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 3.1e-16 216592004107 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 216592004108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592004109 substrate binding pocket [chemical binding]; other site 216592004110 membrane-bound complex binding site; other site 216592004111 hinge residues; other site 216592004112 PS00430 TonB-dependent receptor proteins signature 1. 216592004113 Signal peptide predicted for EC042_0782 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 24 and 25 216592004114 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.1e-09 216592004115 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216592004116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004117 dimer interface [polypeptide binding]; other site 216592004118 conserved gate region; other site 216592004119 putative PBP binding loops; other site 216592004120 ABC-ATPase subunit interface; other site 216592004121 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.5e-20 216592004122 5 probable transmembrane helices predicted for EC042_0783 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 136-158 and 197-219 216592004123 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004124 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 216592004125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592004126 Walker A/P-loop; other site 216592004127 ATP binding site [chemical binding]; other site 216592004128 Q-loop/lid; other site 216592004129 ABC transporter signature motif; other site 216592004130 Walker B; other site 216592004131 D-loop; other site 216592004132 H-loop/switch region; other site 216592004133 molybdenum-pterin binding domain; Region: Mop; TIGR00638 216592004134 HMMPfam hit to PF00005, ABC transporter, score 1.8e-68 216592004135 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004136 PS00211 ABC transporters family signature. 216592004137 HMMPfam hit to PF03459, TOBE domain, score 6e-14 216592004138 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 216592004139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004140 motif II; other site 216592004141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004142 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.8e-14 216592004143 PS01229 Hypothetical cof family signature 2. 216592004144 PS01228 Hypothetical cof family signature 1. 216592004145 6-phosphogluconolactonase; Provisional; Region: PRK11028 216592004146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592004147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592004148 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216592004149 putative dimerization interface [polypeptide binding]; other site 216592004150 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.9e-50 216592004151 1 probable transmembrane helix predicted for EC042_0787 by TMHMM2.0 at aa 93-112 216592004152 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-19 216592004153 PS00044 Bacterial regulatory proteins, lysR family signature. 216592004154 Predicted helix-turn-helix motif with score 1369.000, SD 3.85 at aa 18-39, sequence SSFNNAAKLLNITQPALTRRIK 216592004155 PrpF protein; Region: PrpF; pfam04303 216592004156 HMMPfam hit to PF04303, Protein of unknown function (DUF453), score 1.9e-237 216592004157 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216592004158 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 216592004159 transmembrane helices; other site 216592004160 Signal peptide predicted for EC042_0789 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.404 between residues 26 and 27 216592004161 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 1.3e-273 216592004162 15 probable transmembrane helices predicted for EC042_0789 by TMHMM2.0 at aa 5-27, 31-48, 55-72, 87-105, 112-134, 149-166, 178-200, 220-242, 274-293, 297-314, 327-349, 364-381, 388-410, 420-439 and 446-468 216592004163 putative hydratase; Provisional; Region: PRK11413 216592004164 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 216592004165 substrate binding site [chemical binding]; other site 216592004166 ligand binding site [chemical binding]; other site 216592004167 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 216592004168 substrate binding site [chemical binding]; other site 216592004169 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 1.4e-13 216592004170 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 0.035 216592004171 acyl-CoA thioesterase; Provisional; Region: PRK10531 216592004172 putative pectinesterase; Region: PLN02432; cl01911 216592004173 HMMPfam hit to PF01095, Pectinesterase, score 4.7e-07 216592004174 PS00503 Pectinesterase signature 2. 216592004175 PS00800 Pectinesterase signature 1. 216592004176 Signal peptide predicted for EC042_0791 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.627 between residues 23 and 24 216592004177 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004178 prophage 1. Absent in Uropathogenic, divergent in 0157 (in 0157 O-island #36; cryptic prophage CP-933K), prophage, carrying bactoprenol glucosyl transferase, involved in O antigen modification, like Salmonella bacteriophage P22 216592004179 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 216592004180 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 216592004181 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216592004182 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 216592004183 dimer interface [polypeptide binding]; other site 216592004184 active site 216592004185 Int/Topo IB signature motif; other site 216592004186 HMMPfam hit to PF00589, Phage integrase family, score 2e-31 216592004187 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 4.3e-08 216592004188 Excisionase-like protein; Region: Exc; pfam07825 216592004189 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004190 hypothetical protein; Region: PHA00626 216592004191 Protein of unknown function (DUF551); Region: DUF551; pfam04448 216592004192 HMMPfam hit to PF04448, Protein of unknown function (DUF551), score 1.5e-13 216592004193 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 216592004194 HMMPfam hit to PF04447, Protein of unknown function (DUF550), score 1.4e-19 216592004195 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 216592004196 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 216592004197 HMMPfam hit to PF05565, Siphovirus Gp157, score 2.4e-28 216592004198 RecT family; Region: RecT; pfam03837 216592004199 HMMPfam hit to PF03837, RecT family, score 1.1e-09 216592004200 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 216592004201 cIII protein family; Region: cIII; pfam08134 216592004202 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 216592004203 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 216592004204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592004205 non-specific DNA binding site [nucleotide binding]; other site 216592004206 salt bridge; other site 216592004207 sequence-specific DNA binding site [nucleotide binding]; other site 216592004208 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216592004209 Catalytic site [active] 216592004210 HMMPfam hit to PF00717, Peptidase S24-like, score 1.4e-17 216592004211 HMMPfam hit to PF01381, Helix-turn-helix, score 2.4e-13 216592004212 Predicted helix-turn-helix motif with score 2019.000, SD 6.06 at aa 16-37, sequence LNQAELAQKVGTTQQSIEQLEN 216592004213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592004214 non-specific DNA binding site [nucleotide binding]; other site 216592004215 salt bridge; other site 216592004216 sequence-specific DNA binding site [nucleotide binding]; other site 216592004217 HMMPfam hit to PF01381, Helix-turn-helix, score 1.6e-12 216592004218 Predicted helix-turn-helix motif with score 1539.000, SD 4.43 at aa 61-82, sequence MTQTELATKAGVKQQSIQLIEA 216592004219 Bacteriophage CII protein; Region: Phage_CII; pfam05269 216592004220 HMMPfam hit to PF05269, Bacteriophage CII protein, score 2.2e-55 216592004221 Predicted helix-turn-helix motif with score 2401.000, SD 7.36 at aa 44-65, sequence RGQRKVADALGINESQISRWKD 216592004222 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 216592004223 HMMPfam hit to PF04492, Bacteriophage replication protein O, score 7.2e-160 216592004224 Predicted helix-turn-helix motif with score 1172.000, SD 3.18 at aa 68-89, sequence LTNTQIAAMTGIHHTHVCAAKR 216592004225 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216592004226 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 216592004227 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216592004228 Walker A motif; other site 216592004229 ATP binding site [chemical binding]; other site 216592004230 Walker B motif; other site 216592004231 DNA binding loops [nucleotide binding] 216592004232 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 4.6e-18 216592004233 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 3.1e-97 216592004234 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004235 Predicted helix-turn-helix motif with score 1040.000, SD 2.73 at aa 1-22, sequence MNKKQLAILEKAWDAQISCALK 216592004236 NinB protein; Region: NinB; pfam05772 216592004237 HMMPfam hit to PF05772, NinB protein, score 1.5e-98 216592004238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592004239 Active Sites [active] 216592004240 NINE Protein; Region: NinE; pfam05322 216592004241 1 probable transmembrane helix predicted for EC042_0815 by TMHMM2.0 at aa 7-29 216592004242 NinF protein; Region: NinF; pfam05810 216592004243 HMMPfam hit to PF05810, NinF protein, score 1.4e-40 216592004244 NUMOD4 motif; Region: NUMOD4; pfam07463 216592004245 HNH endonuclease; Region: HNH_3; pfam13392 216592004246 HMMPfam hit to PF07463, NUMOD4 motif, score 1.7e-08 216592004247 HMMPfam hit to PF01844, HNH endonuclease, score 3.8e-12 216592004248 Predicted helix-turn-helix motif with score 1701.000, SD 4.98 at aa 135-156, sequence GKYRDIAKEFGVCAQTVCNIKN 216592004249 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 216592004250 Endodeoxyribonuclease RusA; Region: RusA; cl01885 216592004251 HMMPfam hit to PF05866, Endodeoxyribonuclease RusA, score 5.3e-45 216592004252 Phage NinH protein; Region: Phage_NinH; pfam06322 216592004253 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 216592004254 HMMPfam hit to PF06530, Phage antitermination protein Q, score 9e-47 216592004255 phage holin, lambda family; Region: holin_lambda; TIGR01594 216592004256 HMMPfam hit to PF05106, Phage holin family (Lysis protein S), score 1.7e-30 216592004257 2 probable transmembrane helices predicted for EC042_0824 by TMHMM2.0 at aa 7-29 and 44-63 216592004258 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 216592004259 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592004260 catalytic residue [active] 216592004261 HMMPfam hit to PF00959, Phage lysozyme, score 2.3e-33 216592004262 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216592004263 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 5.6e-102 216592004264 Signal peptide predicted for EC042_0826 by SignalP 2.0 HMM (Signal peptide probability 0.738) with cleavage site probability 0.703 between residues 22 and 23 216592004265 1 probable transmembrane helix predicted for EC042_0826 by TMHMM2.0 at aa 4-23 216592004266 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 216592004267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216592004268 active site 216592004269 HMMPfam hit to PF01844, HNH endonuclease, score 1.9e-13 216592004270 Phage terminase, small subunit; Region: Terminase_4; pfam05119 216592004271 HMMPfam hit to PF05119, Phage terminase, small subunit, score 2e-12 216592004272 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 216592004273 HMMPfam hit to PF03354, Phage Terminase, score 6.1e-134 216592004274 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004275 Predicted helix-turn-helix motif with score 1107.000, SD 2.96 at aa 389-410, sequence THYYSVAPRFWVPYDTVYSVEK 216592004276 Phage-related protein [Function unknown]; Region: COG4695 216592004277 Phage portal protein; Region: Phage_portal; pfam04860 216592004278 HMMPfam hit to PF04860, Phage portal protein, score 5.2e-82 216592004279 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 216592004280 HMMPfam hit to PF04586, Caudovirus prohead protease, score 3e-38 216592004281 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 216592004282 Phage capsid family; Region: Phage_capsid; pfam05065 216592004283 HMMPfam hit to PF05065, Phage capsid family, score 2.9e-124 216592004284 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 216592004285 oligomerization interface [polypeptide binding]; other site 216592004286 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 216592004287 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 216592004288 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 216592004289 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 216592004290 HMMPfam hit to PF06274, Bacteriophage Mu tail sheath protein (GpL, score 0 216592004291 Phage tail tube protein; Region: Tail_tube; pfam10618 216592004292 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 216592004293 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 216592004294 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 216592004295 2 probable transmembrane helices predicted for EC042_0843 by TMHMM2.0 at aa 393-415 and 427-449 216592004296 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 216592004297 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 216592004298 HMMPfam hit to PF07157, DNA circulation protein N-terminus, score 2e-47 216592004299 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 216592004300 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216592004301 HMMPfam hit to PF06893, Bacteriophage Mu P protein, score 2.3e-214 216592004302 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 216592004303 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 216592004304 HMMPfam hit to PF06890, Bacteriophage Mu Gp45 protein, score 1.3e-88 216592004305 Phage protein GP46; Region: GP46; pfam07409 216592004306 HMMPfam hit to PF07409, Phage protein GP46, score 7.2e-69 216592004307 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 216592004308 HMMPfam hit to PF04865, Baseplate J-like protein, score 2.3e-52 216592004309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 216592004310 PS00583 pfkB family of carbohydrate kinases signature 1. 216592004311 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 216592004312 HMMPfam hit to PF02413, Caudovirales tail fibre assembly protein, score 1.6e-30 216592004313 12 probable transmembrane helices predicted for EC042_0853 by TMHMM2.0 at aa 7-29, 58-77, 82-104, 126-148, 155-172, 176-195, 208-230, 245-267, 274-296, 306-326, 333-352 and 362-384 216592004314 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216592004315 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216592004316 Ligand binding site; other site 216592004317 Putative Catalytic site; other site 216592004318 DXD motif; other site 216592004319 2 probable transmembrane helices predicted for EC042_0854 by TMHMM2.0 at aa 227-249 and 264-286 216592004320 HMMPfam hit to PF00535, Glycosyl transferase, score 2e-28 216592004321 Predicted membrane protein [Function unknown]; Region: COG2246 216592004322 HMMPfam hit to PF04138, GtrA-like protein, score 3.5e-21 216592004323 3 probable transmembrane helices predicted for EC042_0855 by TMHMM2.0 at aa 20-42, 55-72 and 82-104 216592004324 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 216592004325 substrate binding site [chemical binding]; other site 216592004326 HMMPfam hit to PF01161, Phosphatidylethanolamine-binding protein, score 2.8e-07 216592004327 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 216592004328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592004329 inhibitor-cofactor binding pocket; inhibition site 216592004330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592004331 catalytic residue [active] 216592004332 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.4e-159 216592004333 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592004334 biotin synthase; Provisional; Region: PRK15108 216592004335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592004336 FeS/SAM binding site; other site 216592004337 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 216592004338 HMMPfam hit to PF04055, Radical SAM superfamily, score 2e-25 216592004339 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 6.1e-54 216592004340 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216592004341 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216592004342 substrate-cofactor binding pocket; other site 216592004343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592004344 catalytic residue [active] 216592004345 HMMPfam hit to PF00155, Aminotransferase class I and II, score 6.6e-70 216592004346 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216592004347 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 216592004348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592004349 S-adenosylmethionine binding site [chemical binding]; other site 216592004350 AAA domain; Region: AAA_26; pfam13500 216592004351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216592004352 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 216592004353 ADP binding site [chemical binding]; other site 216592004354 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6e-30 216592004355 excinuclease ABC subunit B; Provisional; Region: PRK05298 216592004356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592004357 ATP binding site [chemical binding]; other site 216592004358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592004359 nucleotide binding region [chemical binding]; other site 216592004360 ATP-binding site [chemical binding]; other site 216592004361 Ultra-violet resistance protein B; Region: UvrB; pfam12344 216592004362 UvrB/uvrC motif; Region: UVR; pfam02151 216592004363 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 4.2e-06 216592004364 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004365 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-19 216592004366 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.5e-13 216592004367 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 216592004368 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 216592004369 putative substrate binding pocket [chemical binding]; other site 216592004370 dimer interface [polypeptide binding]; other site 216592004371 phosphate binding site [ion binding]; other site 216592004372 HMMPfam hit to PF01933, Uncharacterised protein family UPF0052, score 5.6e-133 216592004373 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 216592004374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592004375 FeS/SAM binding site; other site 216592004376 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 216592004377 HMMPfam hit to PF04055, Radical SAM superfamily, score 2e-39 216592004378 PS01305 moaA / nifB / pqqE family signature. 216592004379 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 1.4e-47 216592004380 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 216592004381 MPT binding site; other site 216592004382 trimer interface [polypeptide binding]; other site 216592004383 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 4.3e-52 216592004384 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 216592004385 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 216592004386 trimer interface [polypeptide binding]; other site 216592004387 dimer interface [polypeptide binding]; other site 216592004388 putative active site [active] 216592004389 HMMPfam hit to PF01967, MoaC family, score 1.2e-95 216592004390 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 216592004391 MoaE interaction surface [polypeptide binding]; other site 216592004392 MoeB interaction surface [polypeptide binding]; other site 216592004393 thiocarboxylated glycine; other site 216592004394 HMMPfam hit to PF02597, ThiS family, score 1.5e-28 216592004395 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 216592004396 MoaE homodimer interface [polypeptide binding]; other site 216592004397 MoaD interaction [polypeptide binding]; other site 216592004398 active site residues [active] 216592004399 HMMPfam hit to PF02391, MoaE protein, score 1.8e-63 216592004400 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 216592004401 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 216592004402 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 6.7e-66 216592004403 7 probable transmembrane helices predicted for EC042_0870 by TMHMM2.0 at aa 51-70, 80-102, 115-134, 139-158, 165-187, 192-211 and 236-258 216592004405 3 probable transmembrane helices predicted for EC042_0872 by TMHMM2.0 at aa 19-41, 56-70 and 77-98 216592004406 3 probable transmembrane helices predicted for EC042_0873 by TMHMM2.0 at aa 20-39, 46-63 and 92-114 216592004407 Unique to 042, 4 hypothetical protein, part of an operon, upstream CDs is pseudogene 216592004408 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 216592004409 1 probable transmembrane helix predicted for EC042_0875 by TMHMM2.0 at aa 64-86 216592004410 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 216592004411 Predicted integral membrane protein [Function unknown]; Region: COG0392 216592004412 8 probable transmembrane helices predicted for EC042_0878 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 131-153, 166-185, 205-227, 234-256 and 281-303 216592004413 Predicted helix-turn-helix motif with score 1112.000, SD 2.97 at aa 107-128, sequence GMRYRLYSRLGLPGSTITRIFS 216592004414 Signal peptide predicted for EC042_0878 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.910 between residues 31 and 32 216592004415 cardiolipin synthase 2; Provisional; Region: PRK11263 216592004416 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 216592004417 putative active site [active] 216592004418 catalytic site [active] 216592004419 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 216592004420 putative active site [active] 216592004421 catalytic site [active] 216592004422 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.2 216592004423 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 7.6e-08 216592004424 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 216592004425 putative catalytic site [active] 216592004426 putative metal binding site [ion binding]; other site 216592004427 putative phosphate binding site [ion binding]; other site 216592004428 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 3e-32 216592004429 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 216592004430 4 probable transmembrane helices predicted for EC042_0881 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119 216592004431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216592004432 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216592004433 6 probable transmembrane helices predicted for EC042_0882 by TMHMM2.0 at aa 24-46, 173-195, 223-245, 255-277, 284-303 and 341-363 216592004434 HMMPfam hit to PF01061, ABC-2 type transporter, score 7.4e-45 216592004435 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216592004436 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 216592004437 6 probable transmembrane helices predicted for EC042_0883 by TMHMM2.0 at aa 27-49, 182-204, 231-253, 263-285, 292-314 and 348-370 216592004438 HMMPfam hit to PF01061, ABC-2 type transporter, score 2.4e-27 216592004439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216592004440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216592004441 Walker A/P-loop; other site 216592004442 ATP binding site [chemical binding]; other site 216592004443 Q-loop/lid; other site 216592004444 ABC transporter signature motif; other site 216592004445 Walker B; other site 216592004446 D-loop; other site 216592004447 H-loop/switch region; other site 216592004448 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 216592004449 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216592004450 Walker A/P-loop; other site 216592004451 ATP binding site [chemical binding]; other site 216592004452 Q-loop/lid; other site 216592004453 ABC transporter signature motif; other site 216592004454 Walker B; other site 216592004455 D-loop; other site 216592004456 H-loop/switch region; other site 216592004457 HMMPfam hit to PF00005, ABC transporter, score 8.6e-51 216592004458 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004459 HMMPfam hit to PF00005, ABC transporter, score 4e-46 216592004460 PS00211 ABC transporters family signature. 216592004461 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004462 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 216592004463 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592004464 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592004465 HMMPfam hit to PF00529, HlyD family secretion protein, score 3e-17 216592004466 1 probable transmembrane helix predicted for EC042_0885 by TMHMM2.0 at aa 7-26 216592004467 Signal peptide predicted for EC042_0885 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.557 between residues 20 and 21 216592004468 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 216592004469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592004470 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 216592004471 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.3e-15 216592004472 PS01081 Bacterial regulatory proteins, tetR family signature. 216592004473 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 36-57, sequence ATTREIAAQAGQNIAAITYYFG 216592004474 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 216592004475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216592004476 ATP binding site [chemical binding]; other site 216592004477 Mg++ binding site [ion binding]; other site 216592004478 motif III; other site 216592004479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592004480 nucleotide binding region [chemical binding]; other site 216592004481 ATP-binding site [chemical binding]; other site 216592004482 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 9.4e-71 216592004483 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004484 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592004485 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2e-33 216592004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 216592004487 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 216592004488 DEAD_2; Region: DEAD_2; pfam06733 216592004489 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 216592004490 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004491 glycosyl transferase family protein; Provisional; Region: PRK08136 216592004492 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216592004493 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 3.4e-23 216592004494 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 1.3e-62 216592004495 putative dehydrogenase; Provisional; Region: PRK10098 216592004496 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 2.2e-215 216592004497 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004498 hypothetical protein; Provisional; Region: PRK10259 216592004499 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.4e-41 216592004500 1 probable transmembrane helix predicted for EC042_0892 by TMHMM2.0 at aa 7-29 216592004501 Signal peptide predicted for EC042_0892 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 22 and 23 216592004502 hypothetical protein; Provisional; Region: PRK11019 216592004503 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 1.8e-38 216592004504 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 216592004505 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 216592004506 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 7.2e-10 216592004507 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 216592004508 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592004509 N-terminal plug; other site 216592004510 ligand-binding site [chemical binding]; other site 216592004511 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-32 216592004512 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.6e-21 216592004513 PS00430 TonB-dependent receptor proteins signature 1. 216592004514 1 probable transmembrane helix predicted for EC042_0895 by TMHMM2.0 at aa 12-34 216592004515 Signal peptide predicted for EC042_0895 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.903 between residues 33 and 34 216592004516 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592004517 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 7.4e-18 216592004518 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 216592004519 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 216592004520 HMMPfam hit to PF05971, Protein of unknown function (DUF890), score 2e-227 216592004521 putative mechanosensitive channel protein; Provisional; Region: PRK11465 216592004522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592004523 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.7e-64 216592004524 12 probable transmembrane helices predicted for EC042_0898 by TMHMM2.0 at aa 20-42, 49-71, 183-205, 226-248, 263-285, 313-332, 337-359, 380-402, 417-439, 477-496, 511-533 and 554-576 216592004525 Signal peptide predicted for EC042_0898 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.951 between residues 63 and 64 216592004526 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 216592004527 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216592004528 Walker A/P-loop; other site 216592004529 ATP binding site [chemical binding]; other site 216592004530 Q-loop/lid; other site 216592004531 ABC transporter signature motif; other site 216592004532 Walker B; other site 216592004533 D-loop; other site 216592004534 H-loop/switch region; other site 216592004535 HMMPfam hit to PF00005, ABC transporter, score 4.4e-74 216592004536 PS00211 ABC transporters family signature. 216592004537 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004538 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004540 dimer interface [polypeptide binding]; other site 216592004541 conserved gate region; other site 216592004542 putative PBP binding loops; other site 216592004543 ABC-ATPase subunit interface; other site 216592004544 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.1e-40 216592004545 3 probable transmembrane helices predicted for EC042_0900 by TMHMM2.0 at aa 20-42, 54-76 and 187-209 216592004546 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004547 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 216592004548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592004549 substrate binding pocket [chemical binding]; other site 216592004550 membrane-bound complex binding site; other site 216592004551 hinge residues; other site 216592004552 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 2.8e-93 216592004553 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592004554 Signal peptide predicted for EC042_0901 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 216592004555 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 216592004556 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 216592004557 dimerization interface [polypeptide binding]; other site 216592004558 DPS ferroxidase diiron center [ion binding]; other site 216592004559 ion pore; other site 216592004560 HMMPfam hit to PF00210, Ferritin-like domain, score 2.4e-28 216592004561 PS00819 Dps protein family signature 2. 216592004562 PS00818 Dps protein family signature 1. 216592004563 threonine and homoserine efflux system; Provisional; Region: PRK10532 216592004564 EamA-like transporter family; Region: EamA; pfam00892 216592004565 10 probable transmembrane helices predicted for EC042_0903 by TMHMM2.0 at aa 12-31, 41-63, 76-93, 97-119, 126-143, 148-170, 183-202, 207-229, 242-261 and 265-287 216592004566 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5e-21 216592004567 Signal peptide predicted for EC042_0903 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.671 between residues 35 and 36 216592004568 outer membrane protein X; Provisional; Region: ompX; PRK09408 216592004569 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 5.9e-18 216592004570 Signal peptide predicted for EC042_0904 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 23 and 24 216592004571 1 probable transmembrane helix predicted for EC042_0904 by TMHMM2.0 at aa 7-29 216592004572 PS00694 Enterobacterial virulence outer membrane protein signature 1. 216592004573 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216592004574 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 216592004575 Sulfatase; Region: Sulfatase; pfam00884 216592004576 HMMPfam hit to PF00884, Sulfatase, score 3e-98 216592004577 4 probable transmembrane helices predicted for EC042_0905 by TMHMM2.0 at aa 32-54, 63-85, 105-127 and 144-166 216592004578 manganese transport regulator MntR; Provisional; Region: PRK11050 216592004579 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 216592004580 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 216592004581 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 55-76, sequence ARQVDMAARLGVSQPTVAKMLK 216592004582 HMMPfam hit to PF02742, Iron dependent repressor, metal binding, score 3.3e-07 216592004583 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216592004584 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 216592004585 transmembrane helices; other site 216592004586 9 probable transmembrane helices predicted for EC042_0907 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 159-181, 202-219, 223-242, 249-268, 312-334 and 347-369 216592004587 L,D-transpeptidase; Provisional; Region: PRK10260 216592004588 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592004589 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 8.4e-67 216592004590 1 probable transmembrane helix predicted for EC042_0908 by TMHMM2.0 at aa 7-29 216592004591 Signal peptide predicted for EC042_0908 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 24 and 25 216592004592 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 216592004593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592004594 Walker A/P-loop; other site 216592004595 ATP binding site [chemical binding]; other site 216592004596 Q-loop/lid; other site 216592004597 ABC transporter signature motif; other site 216592004598 Walker B; other site 216592004599 D-loop; other site 216592004600 H-loop/switch region; other site 216592004601 ABC transporter; Region: ABC_tran_2; pfam12848 216592004602 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592004603 HMMPfam hit to PF00005, ABC transporter, score 2.3e-40 216592004604 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004605 HMMPfam hit to PF00005, ABC transporter, score 1.4e-41 216592004606 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004607 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 216592004608 HMMPfam hit to PF07350, Protein of unknown function (DUF1479), score 0 216592004609 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 216592004610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004611 active site 216592004612 motif I; other site 216592004613 motif II; other site 216592004614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004615 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-05 216592004616 PS01229 Hypothetical cof family signature 2. 216592004617 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 216592004618 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 216592004619 dimer interface [polypeptide binding]; other site 216592004620 active site 216592004621 glycine loop; other site 216592004622 HMMPfam hit to PF01228, Glycine radical, score 1.1e-22 216592004623 PS00850 Glycine radical signature. 216592004624 HMMPfam hit to PF02901, Pyruvate formate lyase, score 0 216592004625 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 216592004626 HMMPfam hit to PF04055, Radical SAM superfamily, score 7.8e-10 216592004627 PS01087 Radical activating enzymes signature. 216592004628 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 216592004629 active site 216592004630 intersubunit interactions; other site 216592004631 catalytic residue [active] 216592004632 HMMPfam hit to PF00923, Transaldolase, score 7.4e-98 216592004633 PS01054 Transaldolase signature 1. 216592004634 PS00958 Transaldolase active site. 216592004635 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 216592004636 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 216592004637 ATP binding site [chemical binding]; other site 216592004638 substrate interface [chemical binding]; other site 216592004639 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 9.9e-38 216592004640 HMMPfam hit to PF00899, ThiF family, score 5.9e-58 216592004641 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 216592004642 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 216592004643 dimer interface [polypeptide binding]; other site 216592004644 putative functional site; other site 216592004645 putative MPT binding site; other site 216592004646 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 5.8e-26 216592004647 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 4.6e-59 216592004648 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 216592004649 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 6.9e-85 216592004650 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 216592004651 catalytic nucleophile [active] 216592004652 HMMPfam hit to PF01112, Asparaginase, score 3.6e-188 216592004653 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 216592004654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592004655 Walker A/P-loop; other site 216592004656 ATP binding site [chemical binding]; other site 216592004657 Q-loop/lid; other site 216592004658 ABC transporter signature motif; other site 216592004659 Walker B; other site 216592004660 D-loop; other site 216592004661 H-loop/switch region; other site 216592004662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592004663 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592004664 Walker A/P-loop; other site 216592004665 ATP binding site [chemical binding]; other site 216592004666 Q-loop/lid; other site 216592004667 ABC transporter signature motif; other site 216592004668 Walker B; other site 216592004669 D-loop; other site 216592004670 H-loop/switch region; other site 216592004671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216592004672 HMMPfam hit to PF00005, ABC transporter, score 3.4e-58 216592004673 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004674 PS00211 ABC transporters family signature. 216592004675 HMMPfam hit to PF00005, ABC transporter, score 3.4e-62 216592004676 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004677 PS00211 ABC transporters family signature. 216592004678 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 216592004679 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 216592004680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004681 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 9.4e-90 216592004682 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592004683 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 216592004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004685 dimer interface [polypeptide binding]; other site 216592004686 conserved gate region; other site 216592004687 putative PBP binding loops; other site 216592004688 ABC-ATPase subunit interface; other site 216592004689 Signal peptide predicted for EC042_0920 by SignalP 2.0 HMM (Signal peptide probability 0.746) with cleavage site probability 0.482 between residues 29 and 30 216592004690 6 probable transmembrane helices predicted for EC042_0920 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189, 227-249 and 278-300 216592004691 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.1e-56 216592004692 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004693 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 216592004694 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216592004695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004696 dimer interface [polypeptide binding]; other site 216592004697 conserved gate region; other site 216592004698 putative PBP binding loops; other site 216592004699 ABC-ATPase subunit interface; other site 216592004700 6 probable transmembrane helices predicted for EC042_0921 by TMHMM2.0 at aa 40-62, 107-129, 136-158, 163-185, 209-231 and 266-288 216592004701 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.5e-47 216592004702 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592004704 Signal peptide predicted for EC042_0922 by SignalP 2.0 HMM (Signal peptide probability 0.917) with cleavage site probability 0.617 between residues 35 and 36 216592004705 2 probable transmembrane helices predicted for EC042_0922 by TMHMM2.0 at aa 10-32 and 287-309 216592004706 HMMPfam hit to PF00563, EAL domain, score 1.8e-101 216592004707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592004708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592004709 metal binding site [ion binding]; metal-binding site 216592004710 active site 216592004711 I-site; other site 216592004712 Signal peptide predicted for EC042_0923 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.951 between residues 23 and 24 216592004713 2 probable transmembrane helices predicted for EC042_0923 by TMHMM2.0 at aa 7-29 and 228-250 216592004714 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004715 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592004716 HMMPfam hit to PF00990, GGDEF domain, score 2.5e-26 216592004717 Predicted transcriptional regulator [Transcription]; Region: COG2944 216592004718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592004719 non-specific DNA binding site [nucleotide binding]; other site 216592004720 salt bridge; other site 216592004721 sequence-specific DNA binding site [nucleotide binding]; other site 216592004722 HMMPfam hit to PF01381, Helix-turn-helix, score 2.5e-07 216592004723 Predicted helix-turn-helix motif with score 2246.000, SD 6.84 at aa 62-83, sequence MSQSVLAHTMGMSKESVSKWER 216592004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 216592004725 HMMPfam hit to PF06296, Protein of unknown function (DUF1044), score 1.8e-79 216592004726 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 216592004727 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216592004728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592004729 FeS/SAM binding site; other site 216592004730 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.4e-29 216592004731 PS01278 Uncharacterized protein family UPF0004 signature. 216592004732 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 1.1e-42 216592004733 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 216592004734 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 216592004735 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 216592004736 Signal peptide predicted for EC042_0928 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 216592004737 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216592004738 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 216592004739 putative C-terminal domain interface [polypeptide binding]; other site 216592004740 putative GSH binding site (G-site) [chemical binding]; other site 216592004741 putative dimer interface [polypeptide binding]; other site 216592004742 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216592004743 N-terminal domain interface [polypeptide binding]; other site 216592004744 dimer interface [polypeptide binding]; other site 216592004745 substrate binding pocket (H-site) [chemical binding]; other site 216592004746 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 6.5e-14 216592004747 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 2.4e-15 216592004748 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 216592004749 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216592004750 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 216592004751 Signal peptide predicted for EC042_0930 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 34 and 35 216592004752 1 probable transmembrane helix predicted for EC042_0930 by TMHMM2.0 at aa 13-35 216592004753 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 2.4e-152 216592004754 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 216592004755 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216592004756 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592004757 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 2.3e-108 216592004758 Predicted helix-turn-helix motif with score 1994.000, SD 5.98 at aa 22-43, sequence LHLKDAAALLGVSEMTIRRDLN 216592004759 PS00894 Bacterial regulatory proteins, deoR family signature. 216592004760 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 216592004761 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216592004762 active site 216592004763 HMMPfam hit to PF01569, PAP2 superfamily, score 4.9e-33 216592004764 4 probable transmembrane helices predicted for EC042_0932 by TMHMM2.0 at aa 32-54, 61-83, 126-148 and 155-177 216592004765 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 216592004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592004767 putative substrate translocation pore; other site 216592004768 12 probable transmembrane helices predicted for EC042_0933 by TMHMM2.0 at aa 12-31, 51-73, 86-103, 108-130, 143-165, 169-188, 220-242, 257-279, 286-308, 313-335, 348-367 and 377-399 216592004769 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-28 216592004770 PS00216 Sugar transport proteins signature 1. 216592004771 1 probable transmembrane helix predicted for EC042_0934 by TMHMM2.0 at aa 5-27 216592004772 Signal peptide predicted for EC042_0934 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 216592004773 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 216592004774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004775 active site 216592004776 motif I; other site 216592004777 motif II; other site 216592004778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592004779 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 9e-12 216592004780 PS01229 Hypothetical cof family signature 2. 216592004781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592004782 putative substrate translocation pore; other site 216592004783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592004784 12 probable transmembrane helices predicted for EC042_0936 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 104-126, 139-161, 165-187, 208-230, 253-275, 282-301, 305-327, 340-362 and 367-389 216592004785 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.9e-25 216592004786 Signal peptide predicted for EC042_0936 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.810 between residues 29 and 30 216592004787 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 216592004788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592004789 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 216592004790 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 6e-09 216592004791 Predicted helix-turn-helix motif with score 1011.000, SD 2.63 at aa 39-60, sequence VTHRKIATLAGVPLGSMTYYFS 216592004792 putative transporter; Provisional; Region: PRK04972 216592004793 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 216592004794 TrkA-C domain; Region: TrkA_C; pfam02080 216592004795 TrkA-C domain; Region: TrkA_C; pfam02080 216592004796 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 216592004797 9 probable transmembrane helices predicted for EC042_0938 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-402, 406-428, 449-471, 476-498 and 535-557 216592004798 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1.4e-63 216592004799 HMMPfam hit to PF02080, TrkA-C domain, score 1.9e-12 216592004800 HMMPfam hit to PF02080, TrkA-C domain, score 2.5e-11 216592004801 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1e-68 216592004802 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 216592004803 Signal peptide predicted for EC042_0939 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.462 between residues 36 and 37 216592004804 4 probable transmembrane helices predicted for EC042_0939 by TMHMM2.0 at aa 7-26, 36-55, 62-84 and 94-116 216592004805 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 216592004806 GSH binding site [chemical binding]; other site 216592004807 catalytic residues [active] 216592004808 HMMPfam hit to PF00462, Glutaredoxin, score 3.4e-26 216592004809 Predicted helix-turn-helix motif with score 1107.000, SD 2.96 at aa 48-69, sequence ITKEDLQQKAGKPVETVPQIFV 216592004810 PS00195 Glutaredoxin active site. 216592004811 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 216592004812 HMMPfam hit to PF07214, Protein of unknown function (DUF1418), score 2.5e-70 216592004813 Signal peptide predicted for EC042_0941 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.877 between residues 34 and 35 216592004814 2 probable transmembrane helices predicted for EC042_0941 by TMHMM2.0 at aa 12-31 and 46-68 216592004815 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 216592004816 dimer interface [polypeptide binding]; other site 216592004817 FMN binding site [chemical binding]; other site 216592004818 NADPH bind site [chemical binding]; other site 216592004819 HMMPfam hit to PF00881, Nitroreductase family, score 2.1e-37 216592004820 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 216592004821 RimK-like ATP-grasp domain; Region: RimK; pfam08443 216592004822 HMMPfam hit to PF02222, ATP-grasp domain, score 7.3e-29 216592004823 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 216592004824 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 216592004825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216592004826 1 probable transmembrane helix predicted for EC042_0945 by TMHMM2.0 at aa 58-77 216592004827 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.8e-11 216592004828 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 216592004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592004830 Walker A/P-loop; other site 216592004831 ATP binding site [chemical binding]; other site 216592004832 Q-loop/lid; other site 216592004833 ABC transporter signature motif; other site 216592004834 Walker B; other site 216592004835 D-loop; other site 216592004836 H-loop/switch region; other site 216592004837 TOBE domain; Region: TOBE_2; pfam08402 216592004838 HMMPfam hit to PF00005, ABC transporter, score 4.3e-68 216592004839 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004840 PS00211 ABC transporters family signature. 216592004841 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216592004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004843 dimer interface [polypeptide binding]; other site 216592004844 conserved gate region; other site 216592004845 putative PBP binding loops; other site 216592004846 ABC-ATPase subunit interface; other site 216592004847 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 216592004848 6 probable transmembrane helices predicted for EC042_0947 by TMHMM2.0 at aa 28-49, 97-119, 132-154, 183-205, 226-248 and 281-303 216592004849 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.1e-33 216592004850 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004851 Signal peptide predicted for EC042_0948 by SignalP 2.0 HMM (Signal peptide probability 0.687) with cleavage site probability 0.498 between residues 59 and 60 216592004852 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216592004853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004854 dimer interface [polypeptide binding]; other site 216592004855 conserved gate region; other site 216592004856 putative PBP binding loops; other site 216592004857 ABC-ATPase subunit interface; other site 216592004858 6 probable transmembrane helices predicted for EC042_0948 by TMHMM2.0 at aa 27-49, 83-105, 118-140, 155-177, 198-220 and 256-278 216592004859 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.00042 216592004860 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004861 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 216592004862 4 probable transmembrane helices predicted for EC042_0949 by TMHMM2.0 at aa 13-35, 60-82, 89-111 and 126-148 216592004863 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 216592004864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592004865 S-adenosylmethionine binding site [chemical binding]; other site 216592004866 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 6.7e-06 216592004867 PS01230 RNA methyltransferase trmA family signature 1. 216592004868 PS01231 RNA methyltransferase trmA family signature 2. 216592004869 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 216592004870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592004871 substrate binding pocket [chemical binding]; other site 216592004872 membrane-bound complex binding site; other site 216592004873 hinge residues; other site 216592004874 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 7.1e-106 216592004875 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592004876 Signal peptide predicted for EC042_0951 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 19 and 20 216592004877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004878 dimer interface [polypeptide binding]; other site 216592004879 conserved gate region; other site 216592004880 putative PBP binding loops; other site 216592004881 ABC-ATPase subunit interface; other site 216592004882 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.8e-10 216592004883 5 probable transmembrane helices predicted for EC042_0952 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-174 and 189-211 216592004884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592004885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592004886 dimer interface [polypeptide binding]; other site 216592004887 conserved gate region; other site 216592004888 putative PBP binding loops; other site 216592004889 ABC-ATPase subunit interface; other site 216592004890 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.4e-18 216592004891 4 probable transmembrane helices predicted for EC042_0953 by TMHMM2.0 at aa 10-32, 45-67, 101-118 and 201-223 216592004892 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592004893 Signal peptide predicted for EC042_0953 by SignalP 2.0 HMM (Signal peptide probability 0.986) with cleavage site probability 0.574 between residues 29 and 30 216592004894 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 216592004895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592004896 substrate binding pocket [chemical binding]; other site 216592004897 membrane-bound complex binding site; other site 216592004898 hinge residues; other site 216592004899 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.1e-92 216592004900 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592004901 Signal peptide predicted for EC042_0954 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 216592004902 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 216592004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592004904 Walker A/P-loop; other site 216592004905 ATP binding site [chemical binding]; other site 216592004906 Q-loop/lid; other site 216592004907 ABC transporter signature motif; other site 216592004908 Walker B; other site 216592004909 D-loop; other site 216592004910 H-loop/switch region; other site 216592004911 HMMPfam hit to PF00005, ABC transporter, score 1.5e-74 216592004912 PS00211 ABC transporters family signature. 216592004913 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004914 putative lipoprotein; Provisional; Region: PRK10533 216592004915 Signal peptide predicted for EC042_0956 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.747 between residues 29 and 30 216592004916 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004917 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216592004918 hypothetical protein; Provisional; Region: PRK02877 216592004919 HMMPfam hit to PF01906, Domain of unknown function DUF74, score 3.6e-61 216592004920 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 216592004921 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216592004922 amidase catalytic site [active] 216592004923 Zn binding residues [ion binding]; other site 216592004924 substrate binding site [chemical binding]; other site 216592004925 Signal peptide predicted for EC042_0959 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.558 between residues 18 and 19 216592004926 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004927 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 3.5e-45 216592004928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216592004929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216592004930 NAD(P) binding site [chemical binding]; other site 216592004931 active site 216592004932 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216592004933 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 216592004934 putative NAD(P) binding site [chemical binding]; other site 216592004935 putative active site [active] 216592004936 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 216592004937 1 probable transmembrane helix predicted for EC042_0961 by TMHMM2.0 at aa 438-460 216592004938 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 216592004939 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 216592004940 tetramer interface [polypeptide binding]; other site 216592004941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592004942 catalytic residue [active] 216592004943 HMMPfam hit to PF01212, Beta-eliminating lyase, score 3e-156 216592004944 pyruvate dehydrogenase; Provisional; Region: PRK09124 216592004945 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 216592004946 PYR/PP interface [polypeptide binding]; other site 216592004947 dimer interface [polypeptide binding]; other site 216592004948 tetramer interface [polypeptide binding]; other site 216592004949 TPP binding site [chemical binding]; other site 216592004950 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216592004951 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 216592004952 TPP-binding site [chemical binding]; other site 216592004953 PS00187 Thiamine pyrophosphate enzymes signature. 216592004954 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 9.3e-55 216592004955 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2.7e-81 216592004956 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 216592004957 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 216592004958 FAD binding pocket [chemical binding]; other site 216592004959 FAD binding motif [chemical binding]; other site 216592004960 phosphate binding motif [ion binding]; other site 216592004961 beta-alpha-beta structure motif; other site 216592004962 NAD binding pocket [chemical binding]; other site 216592004963 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592004964 catalytic loop [active] 216592004965 iron binding site [ion binding]; other site 216592004966 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 4e-19 216592004967 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 0.00012 216592004968 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 5.3e-07 216592004969 hybrid cluster protein; Provisional; Region: PRK05290 216592004970 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592004971 ACS interaction site; other site 216592004972 CODH interaction site; other site 216592004973 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 216592004974 hybrid metal cluster; other site 216592004975 HMMPfam hit to PF03063, Prismane/CO dehydrogenase family, score 2.9e-259 216592004976 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004977 Predicted membrane protein [Function unknown]; Region: COG2431 216592004978 HMMPfam hit to PF03956, Membrane protein of unknown function (DUF340, score 1.3e-88 216592004979 8 probable transmembrane helices predicted for EC042_0966 by TMHMM2.0 at aa 4-20, 32-51, 61-83, 111-133, 138-155, 167-189, 204-226 and 276-298 216592004980 PS00041 Bacterial regulatory proteins, araC family signature. 216592004981 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 216592004982 amphipathic channel; other site 216592004983 Asn-Pro-Ala signature motifs; other site 216592004984 6 probable transmembrane helices predicted for EC042_0967 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 127-149, 156-178 and 205-227 216592004985 HMMPfam hit to PF00230, Major intrinsic protein, score 2.4e-51 216592004986 PS00501 Signal peptidases I serine active site. 216592004987 PS00221 MIP family signature. 216592004988 Signal peptide predicted for EC042_0967 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.956 between residues 26 and 27 216592004989 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592004990 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 216592004991 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 216592004992 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 216592004993 putative active site [active] 216592004994 putative metal-binding site [ion binding]; other site 216592004995 PS00017 ATP/GTP-binding site motif A (P-loop). 216592004996 Protein of unknown function (DUF535); Region: DUF535; pfam04393 216592004997 HMMPfam hit to PF04393, Protein of unknown function (DUF535), score 2.9e-154 216592004998 macrolide transporter subunit MacA; Provisional; Region: PRK11578 216592004999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592005000 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592005001 Signal peptide predicted for EC042_0970 by SignalP 2.0 HMM (Signal peptide probability 0.801) with cleavage site probability 0.477 between residues 31 and 32 216592005002 1 probable transmembrane helix predicted for EC042_0970 by TMHMM2.0 at aa 20-39 216592005003 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00012 216592005004 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 216592005005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216592005006 Walker A/P-loop; other site 216592005007 ATP binding site [chemical binding]; other site 216592005008 Q-loop/lid; other site 216592005009 ABC transporter signature motif; other site 216592005010 Walker B; other site 216592005011 D-loop; other site 216592005012 H-loop/switch region; other site 216592005013 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216592005014 FtsX-like permease family; Region: FtsX; pfam02687 216592005015 HMMPfam hit to PF00005, ABC transporter, score 7.6e-59 216592005016 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005017 PS00211 ABC transporters family signature. 216592005018 4 probable transmembrane helices predicted for EC042_0971 by TMHMM2.0 at aa 273-295, 527-549, 572-594 and 609-631 216592005019 HMMPfam hit to PF02687, Predicted permease, score 2.9e-54 216592005020 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592005021 DNA-binding site [nucleotide binding]; DNA binding site 216592005022 RNA-binding motif; other site 216592005023 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 9.6e-40 216592005024 PS00352 'Cold-shock' DNA-binding domain signature. 216592005025 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 216592005026 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 2.1e-51 216592005027 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 216592005028 Clp amino terminal domain; Region: Clp_N; pfam02861 216592005029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592005030 Walker A motif; other site 216592005031 ATP binding site [chemical binding]; other site 216592005032 Walker B motif; other site 216592005033 arginine finger; other site 216592005034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592005035 Walker A motif; other site 216592005036 ATP binding site [chemical binding]; other site 216592005037 Walker B motif; other site 216592005038 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216592005039 HMMPfam hit to PF02861, Clp amino terminal domain, score 8e-17 216592005040 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.8e-20 216592005041 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005042 PS00870 Chaperonins clpA/B signature 1. 216592005043 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1e-88 216592005044 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005045 PS00871 Chaperonins clpA/B signature 2. 216592005046 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 216592005047 rRNA binding site [nucleotide binding]; other site 216592005048 predicted 30S ribosome binding site; other site 216592005049 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.2e-10 216592005050 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 216592005051 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 1e-117 216592005052 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 216592005053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592005054 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 216592005055 Walker A/P-loop; other site 216592005056 ATP binding site [chemical binding]; other site 216592005057 Q-loop/lid; other site 216592005058 ABC transporter signature motif; other site 216592005059 Walker B; other site 216592005060 D-loop; other site 216592005061 H-loop/switch region; other site 216592005062 HMMPfam hit to PF00005, ABC transporter, score 1e-61 216592005063 PS00211 ABC transporters family signature. 216592005064 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005065 6 probable transmembrane helices predicted for EC042_0978 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182, 246-268 and 278-300 216592005066 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.00063 216592005067 Signal peptide predicted for EC042_0978 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.922 between residues 49 and 50 216592005068 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 216592005069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592005070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592005071 Walker A/P-loop; other site 216592005072 ATP binding site [chemical binding]; other site 216592005073 Q-loop/lid; other site 216592005074 ABC transporter signature motif; other site 216592005075 Walker B; other site 216592005076 D-loop; other site 216592005077 H-loop/switch region; other site 216592005078 HMMPfam hit to PF00005, ABC transporter, score 3.2e-68 216592005079 PS00211 ABC transporters family signature. 216592005080 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005081 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 9.3e-47 216592005082 5 probable transmembrane helices predicted for EC042_0979 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185 and 246-268 216592005083 thioredoxin reductase; Provisional; Region: PRK10262 216592005084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592005085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592005086 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 5e-75 216592005087 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 216592005088 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 216592005089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592005090 putative DNA binding site [nucleotide binding]; other site 216592005091 putative Zn2+ binding site [ion binding]; other site 216592005092 AsnC family; Region: AsnC_trans_reg; pfam01037 216592005093 PS00519 Bacterial regulatory proteins, asnC family signature. 216592005094 HMMPfam hit to PF01037, AsnC family, score 7.8e-57 216592005095 DNA translocase FtsK; Provisional; Region: PRK10263 216592005096 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 216592005097 DNA translocase FtsK; Provisional; Region: PRK10263 216592005098 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216592005099 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 216592005100 5 probable transmembrane helices predicted for EC042_0982 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-158 and 165-187 216592005101 HMMPfam hit to PF00904, no description, score 3e+02 216592005102 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 1.1e-105 216592005103 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005104 periplasmic chaperone LolA; Region: lolA; TIGR00547 216592005105 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 216592005106 Signal peptide predicted for EC042_0983 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 and 22 216592005107 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 9.8e-116 216592005108 recombination factor protein RarA; Reviewed; Region: PRK13342 216592005109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592005110 Walker A motif; other site 216592005111 ATP binding site [chemical binding]; other site 216592005112 Walker B motif; other site 216592005113 arginine finger; other site 216592005114 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 216592005115 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.3e-22 216592005116 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005117 seryl-tRNA synthetase; Provisional; Region: PRK05431 216592005118 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 216592005119 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 216592005120 dimer interface [polypeptide binding]; other site 216592005121 active site 216592005122 motif 1; other site 216592005123 motif 2; other site 216592005124 motif 3; other site 216592005125 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 2.5e-48 216592005126 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 1.7e-57 216592005127 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592005128 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 216592005129 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 216592005130 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 216592005131 putative [Fe4-S4] binding site [ion binding]; other site 216592005132 putative molybdopterin cofactor binding site [chemical binding]; other site 216592005133 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 216592005134 putative molybdopterin cofactor binding site; other site 216592005135 Signal peptide predicted for EC042_0986 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.951 between residues 45 and 46 216592005136 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 4.7e-19 216592005137 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592005138 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2e-190 216592005139 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592005140 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.5e-48 216592005141 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592005142 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 216592005143 4Fe-4S binding domain; Region: Fer4; pfam00037 216592005144 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.3e-07 216592005145 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592005146 PS00190 Cytochrome c family heme-binding site signature. 216592005147 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 216592005148 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 6.6e-173 216592005149 8 probable transmembrane helices predicted for EC042_0988 by TMHMM2.0 at aa 31-53, 66-88, 103-125, 138-155, 170-192, 199-221, 247-264 and 276-298 216592005150 Isochorismatase family; Region: Isochorismatase; pfam00857 216592005151 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 216592005152 catalytic triad [active] 216592005153 dimer interface [polypeptide binding]; other site 216592005154 conserved cis-peptide bond; other site 216592005155 HMMPfam hit to PF00857, Isochorismatase family, score 2.9e-62 216592005156 putative MFS family transporter protein; Provisional; Region: PRK03633 216592005157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592005158 putative substrate translocation pore; other site 216592005159 Signal peptide predicted for EC042_0990 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.682 between residues 23 and 24 216592005160 12 probable transmembrane helices predicted for EC042_0990 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 131-150, 160-182, 204-226, 236-258, 265-282, 286-308, 320-342 and 352-369 216592005161 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-28 216592005162 PS00237 G-protein coupled receptors signature. 216592005163 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592005164 Amino acid permease; Region: AA_permease_2; pfam13520 216592005165 13 probable transmembrane helices predicted for EC042_0991 by TMHMM2.0 at aa 4-23, 74-91, 101-123, 136-158, 192-211, 223-245, 260-282, 303-325, 352-374, 405-427, 442-464, 477-499 and 509-531 216592005166 HMMPfam hit to PF00324, Amino acid permease, score 0.0011 216592005167 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 216592005168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592005169 FeS/SAM binding site; other site 216592005170 HMMPfam hit to PF04055, Radical SAM superfamily, score 3.7e-27 216592005171 PS01087 Radical activating enzymes signature. 216592005172 PS00190 Cytochrome c family heme-binding site signature. 216592005173 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 216592005174 Pyruvate formate lyase 1; Region: PFL1; cd01678 216592005175 coenzyme A binding site [chemical binding]; other site 216592005176 active site 216592005177 catalytic residues [active] 216592005178 glycine loop; other site 216592005179 HMMPfam hit to PF01228, Glycine radical, score 1e-68 216592005180 PS00850 Glycine radical signature. 216592005181 HMMPfam hit to PF02901, Pyruvate formate lyase, score 0 216592005182 formate transporter; Provisional; Region: PRK10805 216592005183 HMMPfam hit to PF01226, Formate/nitrite transporter, score 1.3e-179 216592005184 8 probable transmembrane helices predicted for EC042_0994 by TMHMM2.0 at aa 7-26, 31-50, 148-170, 190-212, 232-254, 274-296, 308-330 and 369-391 216592005185 PS01006 Formate and nitrite transporters signature 2. 216592005186 PS01005 Formate and nitrite transporters signature 1. 216592005187 uncharacterized domain; Region: TIGR00702 216592005188 YcaO-like family; Region: YcaO; pfam02624 216592005189 HMMPfam hit to PF02624, YcaO-like fatty acid binding protein, score 2.5e-256 216592005190 Predicted membrane protein [Function unknown]; Region: COG2323 216592005191 3 probable transmembrane helices predicted for EC042_0996 by TMHMM2.0 at aa 15-37, 50-69 and 74-91 216592005192 HMMPfam hit to PF04239, Protein of unknown function (DUF421), score 2.6e-36 216592005193 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 216592005194 homodimer interface [polypeptide binding]; other site 216592005195 substrate-cofactor binding pocket; other site 216592005196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592005197 catalytic residue [active] 216592005198 HMMPfam hit to PF00266, Aminotransferase class-V, score 5e-138 216592005199 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216592005200 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 216592005201 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 216592005202 hinge; other site 216592005203 active site 216592005204 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 4e-219 216592005205 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005206 PS00104 EPSP synthase signature 1. 216592005207 PS00885 EPSP synthase signature 2. 216592005208 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 216592005209 Signal peptide predicted for EC042_0999 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.895 between residues 28 and 29 216592005210 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005211 HMMPfam hit to PF01435, Peptidase family M48, score 1.9e-28 216592005212 cytidylate kinase; Provisional; Region: cmk; PRK00023 216592005213 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 216592005214 CMP-binding site; other site 216592005215 The sites determining sugar specificity; other site 216592005216 HMMPfam hit to PF02224, Cytidylate kinase, score 1.3e-94 216592005217 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 216592005218 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 216592005219 RNA binding site [nucleotide binding]; other site 216592005220 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 216592005221 RNA binding site [nucleotide binding]; other site 216592005222 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 216592005223 RNA binding site [nucleotide binding]; other site 216592005224 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 216592005225 RNA binding site [nucleotide binding]; other site 216592005226 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 216592005227 RNA binding site [nucleotide binding]; other site 216592005228 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.3e-12 216592005229 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.2e-17 216592005230 HMMPfam hit to PF00575, S1 RNA binding domain, score 7e-32 216592005231 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.9e-30 216592005232 HMMPfam hit to PF00575, S1 RNA binding domain, score 5.4e-26 216592005233 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.9e-27 216592005234 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216592005235 IHF dimer interface [polypeptide binding]; other site 216592005236 IHF - DNA interface [nucleotide binding]; other site 216592005237 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 9.1e-47 216592005238 PS00045 Bacterial histone-like DNA-binding proteins signature. 216592005239 ComEC family competence protein; Provisional; Region: PRK11539 216592005240 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 216592005241 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 216592005242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 216592005243 7 probable transmembrane helices predicted for EC042_1003 by TMHMM2.0 at aa 29-51, 66-88, 248-270, 280-302, 348-370, 385-407 and 414-436 216592005244 HMMPfam hit to PF03772, Competence protein, score 5.2e-90 216592005245 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.3e-12 216592005246 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 216592005247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592005248 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 216592005249 Walker A/P-loop; other site 216592005250 ATP binding site [chemical binding]; other site 216592005251 Q-loop/lid; other site 216592005252 ABC transporter signature motif; other site 216592005253 Walker B; other site 216592005254 D-loop; other site 216592005255 H-loop/switch region; other site 216592005256 Signal peptide predicted for EC042_1004 by SignalP 2.0 HMM (Signal peptide probability 0.659) with cleavage site probability 0.402 between residues 38 and 39 216592005257 5 probable transmembrane helices predicted for EC042_1004 by TMHMM2.0 at aa 21-43, 63-85, 140-162, 167-186 and 245-267 216592005258 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.1e-70 216592005259 HMMPfam hit to PF00005, ABC transporter, score 5.5e-67 216592005260 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005261 PS00211 ABC transporters family signature. 216592005262 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 216592005263 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 216592005264 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 9e-188 216592005265 1 probable transmembrane helix predicted for EC042_1005 by TMHMM2.0 at aa 15-34 216592005266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 216592005267 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 216592005268 HMMPfam hit to PF06224, Protein of unknown function (DUF1006), score 3.6e-258 216592005269 hypothetical protein; Provisional; Region: PRK11827 216592005270 HMMPfam hit to PF03966, Protein of unknown function (DUF343), score 9.5e-24 216592005271 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 216592005272 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 216592005273 Ligand binding site; other site 216592005274 oligomer interface; other site 216592005275 HMMPfam hit to PF02348, Cytidylyltransferase, score 5e-99 216592005276 hypothetical protein; Provisional; Region: PRK10593 216592005277 Uncharacterized conserved protein [Function unknown]; Region: COG1434 216592005278 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216592005279 putative active site [active] 216592005280 HMMPfam hit to PF02698, DUF218 domain, score 6.9e-47 216592005281 2 probable transmembrane helices predicted for EC042_1011 by TMHMM2.0 at aa 10-32 and 39-58 216592005282 Signal peptide predicted for EC042_1011 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.542 between residues 36 and 37 216592005283 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216592005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592005285 S-adenosylmethionine binding site [chemical binding]; other site 216592005286 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005287 condesin subunit F; Provisional; Region: PRK05260 216592005288 HMMPfam hit to PF03882, KicB killing factor, score 0 216592005289 condesin subunit E; Provisional; Region: PRK05256 216592005290 HMMPfam hit to PF04288, MukE-like family, score 1.5e-166 216592005291 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 216592005292 MukB N-terminal; Region: MukB; pfam04310 216592005293 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 216592005294 HMMPfam hit to PF04310, MukB N-terminal, score 5.8e-188 216592005295 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005296 murein L,D-transpeptidase; Provisional; Region: PRK10594 216592005297 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216592005298 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592005299 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592005300 Signal peptide predicted for EC042_1016 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.940 between residues 30 and 31 216592005301 PS00092 N-6 Adenine-specific DNA methylases signature. 216592005302 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 216592005304 Peptidase M15; Region: Peptidase_M15_3; cl01194 216592005305 Signal peptide predicted for EC042_1017 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 30 and 31 216592005306 1 probable transmembrane helix predicted for EC042_1017 by TMHMM2.0 at aa 12-34 216592005307 HMMPfam hit to PF05951, Bacterial protein of unknown function (DUF88, score 1.1e-104 216592005308 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216592005309 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.2e-37 216592005310 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 216592005311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592005312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592005313 homodimer interface [polypeptide binding]; other site 216592005314 catalytic residue [active] 216592005315 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.2e-118 216592005316 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216592005317 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592005318 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592005319 trimer interface [polypeptide binding]; other site 216592005320 eyelet of channel; other site 216592005321 HMMPfam hit to PF00267, Gram-negative porin, score 2.9e-184 216592005322 PS00576 General diffusion Gram-negative porins signature. 216592005323 Signal peptide predicted for EC042_1020 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 216592005324 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 216592005325 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 216592005326 putative dimer interface [polypeptide binding]; other site 216592005327 putative anticodon binding site; other site 216592005328 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 216592005329 homodimer interface [polypeptide binding]; other site 216592005330 motif 1; other site 216592005331 motif 2; other site 216592005332 active site 216592005333 motif 3; other site 216592005334 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.5e-178 216592005335 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592005336 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592005337 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 4.5e-19 216592005338 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 216592005339 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 216592005340 active site 216592005341 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 1.8e-212 216592005342 aminopeptidase N; Provisional; Region: pepN; PRK14015 216592005343 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 216592005344 active site 216592005345 Zn binding site [ion binding]; other site 216592005346 HMMPfam hit to PF01433, Peptidase family M1, score 1.2e-72 216592005347 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592005348 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 216592005349 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216592005350 Walker A/P-loop; other site 216592005351 ATP binding site [chemical binding]; other site 216592005352 Q-loop/lid; other site 216592005353 ABC transporter signature motif; other site 216592005354 Walker B; other site 216592005355 D-loop; other site 216592005356 H-loop/switch region; other site 216592005357 HMMPfam hit to PF00005, ABC transporter, score 3.5e-57 216592005358 PS00211 ABC transporters family signature. 216592005359 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005360 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216592005361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592005362 dimer interface [polypeptide binding]; other site 216592005363 conserved gate region; other site 216592005364 putative PBP binding loops; other site 216592005365 ABC-ATPase subunit interface; other site 216592005366 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.8e-37 216592005367 7 probable transmembrane helices predicted for EC042_1025 by TMHMM2.0 at aa 13-35, 69-91, 104-123, 127-149, 162-184, 189-211 and 224-246 216592005368 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 216592005369 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216592005370 active site 216592005371 dimer interface [polypeptide binding]; other site 216592005372 non-prolyl cis peptide bond; other site 216592005373 insertion regions; other site 216592005374 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 0.0002 216592005375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592005376 substrate binding pocket [chemical binding]; other site 216592005377 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216592005378 membrane-bound complex binding site; other site 216592005379 hinge residues; other site 216592005380 Signal peptide predicted for EC042_1027 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.987 between residues 23 and 24 216592005381 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 216592005382 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216592005383 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 1.1e-59 216592005384 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 216592005385 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 216592005386 quinone interaction residues [chemical binding]; other site 216592005387 active site 216592005388 catalytic residues [active] 216592005389 FMN binding site [chemical binding]; other site 216592005390 substrate binding site [chemical binding]; other site 216592005391 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 6e-173 216592005392 PS00911 Dihydroorotate dehydrogenase signature 1. 216592005393 PS00912 Dihydroorotate dehydrogenase signature 2. 216592005394 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 216592005395 HMMPfam hit to PF07126, Protein of unknown function (DUF1379), score 4.5e-129 216592005396 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 216592005397 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 216592005398 MOSC domain; Region: MOSC; pfam03473 216592005399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592005400 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216592005401 catalytic loop [active] 216592005402 iron binding site [ion binding]; other site 216592005403 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 1.1e-17 216592005404 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216592005405 HMMPfam hit to PF03473, MOSC domain, score 1.4e-59 216592005406 HMMPfam hit to PF03476, MOSC N-terminal beta barrel domain, score 3.1e-50 216592005407 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592005408 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 216592005409 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 216592005410 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 216592005411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592005412 S-adenosylmethionine binding site [chemical binding]; other site 216592005413 HMMPfam hit to PF02926, THUMP domain, score 1.7e-22 216592005414 HMMPfam hit to PF01170, Putative RNA methylase family UPF0020, score 1.2e-106 216592005415 PS01261 Uncharacterized protein family UPF0020 signature. 216592005416 PS00092 N-6 Adenine-specific DNA methylases signature. 216592005417 ABC transporter ATPase component; Reviewed; Region: PRK11147 216592005418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592005419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592005420 Walker A/P-loop; other site 216592005421 Walker A/P-loop; other site 216592005422 ATP binding site [chemical binding]; other site 216592005423 ATP binding site [chemical binding]; other site 216592005424 Q-loop/lid; other site 216592005425 Q-loop/lid; other site 216592005426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592005427 ABC transporter signature motif; other site 216592005428 Walker B; other site 216592005429 D-loop; other site 216592005430 ABC transporter; Region: ABC_tran_2; pfam12848 216592005431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592005432 HMMPfam hit to PF00005, ABC transporter, score 3e-44 216592005433 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005434 PS00211 ABC transporters family signature. 216592005435 HMMPfam hit to PF00005, ABC transporter, score 2.8e-40 216592005436 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005437 PS00211 ABC transporters family signature. 216592005438 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 216592005439 Paraquat-inducible protein A; Region: PqiA; pfam04403 216592005440 Paraquat-inducible protein A; Region: PqiA; pfam04403 216592005441 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.1e-95 216592005442 8 probable transmembrane helices predicted for EC042_1034 by TMHMM2.0 at aa 53-75, 100-122, 135-157, 162-184, 255-277, 304-326, 350-372 and 377-399 216592005443 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 3.9e-105 216592005444 paraquat-inducible protein B; Provisional; Region: PRK10807 216592005445 mce related protein; Region: MCE; pfam02470 216592005446 mce related protein; Region: MCE; pfam02470 216592005447 mce related protein; Region: MCE; pfam02470 216592005448 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 216592005449 1 probable transmembrane helix predicted for EC042_1035 by TMHMM2.0 at aa 36-58 216592005450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 216592005451 Protein of unknown function (DUF330); Region: DUF330; pfam03886 216592005452 Signal peptide predicted for EC042_1036 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.790 between residues 19 and 20 216592005453 HMMPfam hit to PF03886, Protein of unknown function (DUF330), score 2.1e-107 216592005454 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005455 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 216592005456 active site 1 [active] 216592005457 dimer interface [polypeptide binding]; other site 216592005458 active site 2 [active] 216592005459 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 216592005460 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216592005461 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 216592005462 HMMPfam hit to PF06303, Protein of unknown function (DUF1047), score 3.6e-122 216592005463 outer membrane protein A; Reviewed; Region: PRK10808 216592005464 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 216592005465 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592005466 ligand binding site [chemical binding]; other site 216592005467 HMMPfam hit to PF00691, OmpA family, score 6.5e-49 216592005468 PS01068 OmpA-like domain. 216592005469 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 3e-124 216592005470 Signal peptide predicted for EC042_1042 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22 216592005471 cell division inhibitor SulA; Region: sula; TIGR00623 216592005472 HMMPfam hit to PF03846, Cell division inhibitor SulA, score 3.8e-97 216592005473 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 216592005474 TfoX C-terminal domain; Region: TfoX_C; pfam04994 216592005475 HMMPfam hit to PF04993, TfoX N-terminal domain, score 6.2e-08 216592005476 HMMPfam hit to PF04994, TfoX C-terminal domain, score 7.3e-49 216592005477 TIGR01666 family membrane protein; Region: YCCS 216592005478 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 216592005479 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592005480 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 0 216592005481 8 probable transmembrane helices predicted for EC042_1046 by TMHMM2.0 at aa 20-39, 72-94, 114-136, 143-165, 408-430, 443-465, 485-506 and 513-535 216592005482 PS00217 Sugar transport proteins signature 2. 216592005483 Predicted membrane protein [Function unknown]; Region: COG3304 216592005484 Domain of unknown function (DUF307); Region: DUF307; pfam03733 216592005485 Domain of unknown function (DUF307); Region: DUF307; pfam03733 216592005486 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 8.9e-32 216592005487 3 probable transmembrane helices predicted for EC042_1047 by TMHMM2.0 at aa 15-37, 77-99 and 103-125 216592005488 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 3.2e-19 216592005489 DNA helicase IV; Provisional; Region: helD; PRK11054 216592005490 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 216592005491 Part of AAA domain; Region: AAA_19; pfam13245 216592005492 Family description; Region: UvrD_C_2; pfam13538 216592005493 HMMPfam hit to PF00580, UvrD/REP helicase, score 5.9e-19 216592005494 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005495 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 216592005496 active site 216592005497 dimer interfaces [polypeptide binding]; other site 216592005498 catalytic residues [active] 216592005499 HMMPfam hit to PF02142, MGS-like domain, score 1.1e-26 216592005500 PS01335 Methylglyoxal synthase active site. 216592005501 hypothetical protein; Provisional; Region: PRK03641 216592005502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 216592005503 Signal peptide predicted for EC042_1050 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.994 between residues 20 and 21 216592005504 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 216592005505 HMMPfam hit to PF02629, CoA binding domain, score 1.4e-30 216592005506 heat shock protein HspQ; Provisional; Region: PRK14129 216592005507 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 216592005508 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 216592005509 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 216592005510 putative RNA binding site [nucleotide binding]; other site 216592005511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592005512 S-adenosylmethionine binding site [chemical binding]; other site 216592005513 PS00294 Prenyl group binding site (CAAX box). 216592005514 Acylphosphatase; Region: Acylphosphatase; cl00551 216592005515 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 216592005516 sulfur transfer protein TusE; Provisional; Region: PRK11508 216592005517 HMMPfam hit to PF04358, DsrC like protein, score 1.2e-80 216592005518 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 216592005519 YccA-like proteins; Region: YccA_like; cd10433 216592005520 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 1.1e-61 216592005521 7 probable transmembrane helices predicted for EC042_1056 by TMHMM2.0 at aa 21-40, 45-67, 74-96, 106-125, 132-154, 159-181 and 194-216 216592005522 PS01243 Uncharacterized protein family UPF0005 signature. 216592005523 Signal peptide predicted for EC042_1056 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.747 between residues 41 and 42 216592005524 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 216592005525 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 216592005526 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 216592005527 Signal peptide predicted for EC042_1057 by SignalP 2.0 HMM (Signal peptide probability 0.699) with cleavage site probability 0.629 between residues 45 and 46 216592005528 2 probable transmembrane helices predicted for EC042_1057 by TMHMM2.0 at aa 20-39 and 326-348 216592005529 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1.6e-18 216592005530 hydrogenase 1 large subunit; Provisional; Region: PRK10170 216592005531 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 216592005532 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, score 0 216592005533 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 216592005534 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 216592005535 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 216592005536 HMMPfam hit to PF01292, Cytochrome b561 family, score 1.2e-85 216592005537 PS00882 Nickel-dependent hydrogenases b-type cytochrome subunit signature 1. 216592005538 4 probable transmembrane helices predicted for EC042_1059 by TMHMM2.0 at aa 20-39, 59-81, 128-150 and 186-203 216592005539 PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2. 216592005540 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 216592005541 putative substrate-binding site; other site 216592005542 nickel binding site [ion binding]; other site 216592005543 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 3.4e-58 216592005544 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 216592005545 HMMPfam hit to PF07449, Hydrogenase-1 expression protein HyaE, score 2.9e-63 216592005546 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 216592005547 HMMPfam hit to PF04809, HupH hydrogenase expression protein, C-termi, score 2e-71 216592005548 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 216592005549 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 216592005550 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 0 216592005551 9 probable transmembrane helices predicted for EC042_1063 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 125-147, 186-208, 215-237, 387-409, 421-443 and 466-488 216592005552 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 216592005553 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 216592005554 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 6.4e-217 216592005555 8 probable transmembrane helices predicted for EC042_1064 by TMHMM2.0 at aa 7-24, 78-100, 121-143, 166-188, 209-231, 263-285, 292-314 and 334-356 216592005556 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 216592005557 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 216592005558 catalytic core [active] 216592005559 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 216592005560 Signal peptide predicted for EC042_1065 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 32 and 33 216592005561 HMMPfam hit to PF00328, Histidine acid phosphatase, score 2.7e-154 216592005562 PS00616 Histidine acid phosphatases phosphohistidine signature. 216592005563 PS00778 Histidine acid phosphatases active site signature. 216592005564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592005565 DNA-binding site [nucleotide binding]; DNA binding site 216592005566 RNA-binding motif; other site 216592005567 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 3.5e-44 216592005568 PS00352 'Cold-shock' DNA-binding domain signature. 216592005569 GnsA/GnsB family; Region: GnsAB; pfam08178 216592005570 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 216592005571 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216592005572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592005573 5 probable transmembrane helices predicted for EC042_1068 by TMHMM2.0 at aa 37-54, 92-114, 159-181, 196-218 and 310-332 216592005574 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00065 216592005575 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592005576 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7.4e-05 216592005577 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592005578 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 216592005579 HAMP domain; Region: HAMP; pfam00672 216592005580 dimerization interface [polypeptide binding]; other site 216592005581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592005582 dimer interface [polypeptide binding]; other site 216592005583 phosphorylation site [posttranslational modification] 216592005584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592005585 ATP binding site [chemical binding]; other site 216592005586 Mg2+ binding site [ion binding]; other site 216592005587 G-X-G motif; other site 216592005588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592005589 active site 216592005590 phosphorylation site [posttranslational modification] 216592005591 intermolecular recognition site; other site 216592005592 dimerization interface [polypeptide binding]; other site 216592005593 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216592005594 putative binding surface; other site 216592005595 active site 216592005596 HMMPfam hit to PF01627, Hpt domain, score 1.9e-15 216592005597 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-13 216592005598 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 4.7e-42 216592005599 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592005600 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.1e-21 216592005601 HMMPfam hit to PF00672, HAMP domain, score 5.4e-10 216592005602 3 probable transmembrane helices predicted for EC042_1069 by TMHMM2.0 at aa 40-62, 68-90 and 390-412 216592005603 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 216592005604 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 216592005605 putative ligand binding site [chemical binding]; other site 216592005606 Signal peptide predicted for EC042_1070 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 18 and 19 216592005607 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.4e-114 216592005608 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 216592005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592005610 active site 216592005611 phosphorylation site [posttranslational modification] 216592005612 intermolecular recognition site; other site 216592005613 dimerization interface [polypeptide binding]; other site 216592005614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592005615 DNA binding site [nucleotide binding] 216592005616 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.3e-18 216592005617 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-41 216592005618 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 216592005619 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 216592005620 Signal peptide predicted for EC042_1072 by SignalP 2.0 HMM (Signal peptide probability 0.806) with cleavage site probability 0.383 between residues 40 and 41 216592005621 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 2.7e-122 216592005622 1 probable transmembrane helix predicted for EC042_1072 by TMHMM2.0 at aa 17-39 216592005623 PS00190 Cytochrome c family heme-binding site signature. 216592005624 PS00190 Cytochrome c family heme-binding site signature. 216592005625 PS00190 Cytochrome c family heme-binding site signature. 216592005626 PS00190 Cytochrome c family heme-binding site signature. 216592005627 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 216592005628 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 216592005629 molybdopterin cofactor binding site [chemical binding]; other site 216592005630 substrate binding site [chemical binding]; other site 216592005631 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 216592005632 molybdopterin cofactor binding site; other site 216592005633 Signal peptide predicted for EC042_1073 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.519 between residues 42 and 43 216592005634 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.1e-199 216592005635 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592005636 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.1e-47 216592005637 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592005638 chaperone protein TorD; Validated; Region: torD; PRK04976 216592005639 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 2.3e-51 216592005640 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 216592005641 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 216592005642 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 216592005643 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216592005644 HSP70 interaction site [polypeptide binding]; other site 216592005645 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216592005646 substrate binding site [polypeptide binding]; other site 216592005647 dimer interface [polypeptide binding]; other site 216592005648 HMMPfam hit to PF01556, DnaJ C terminal region, score 1.4e-35 216592005649 HMMPfam hit to PF00226, DnaJ domain, score 3.8e-34 216592005650 PS00636 Nt-dnaJ domain signature. 216592005651 hypothetical protein; Provisional; Region: PRK09784 216592005652 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 216592005653 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 216592005654 catalytic core [active] 216592005655 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 216592005656 Signal peptide predicted for EC042_1078 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 216592005657 HMMPfam hit to PF00328, Histidine acid phosphatase, score 6.1e-157 216592005658 PS00616 Histidine acid phosphatases phosphohistidine signature. 216592005659 PS00778 Histidine acid phosphatases active site signature. 216592005660 hypothetical protein; Provisional; Region: PRK10174 216592005661 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 216592005662 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216592005663 HMMPfam hit to PF00258, Flavodoxin, score 2e-26 216592005664 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 216592005665 11 probable transmembrane helices predicted for EC042_1081 by TMHMM2.0 at aa 53-75, 82-99, 109-131, 144-163, 173-190, 197-219, 243-265, 286-308, 323-345, 352-374 and 399-421 216592005666 HMMPfam hit to PF00860, Permease family, score 3.4e-141 216592005667 PS01116 Xanthine/uracil permeases family signature. 216592005668 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 216592005669 HMMPfam hit to PF01613, Flavin reductase like domain, score 3.6e-69 216592005670 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 216592005671 putative FMN binding site [chemical binding]; other site 216592005672 PS00294 Prenyl group binding site (CAAX box). 216592005673 HMMPfam hit to PF00881, Nitroreductase family, score 4.6e-08 216592005674 pyrimidine utilization protein D; Region: RutD; TIGR03611 216592005675 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 4.9e-19 216592005676 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216592005677 homotrimer interaction site [polypeptide binding]; other site 216592005678 putative active site [active] 216592005679 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.1e-48 216592005680 PS01094 Uncharacterized protein family UPF0076 signature. 216592005681 Signal peptide predicted for EC042_1085 by SignalP 2.0 HMM (Signal peptide probability 0.905) with cleavage site probability 0.886 between residues 24 and 25 216592005682 Isochorismatase family; Region: Isochorismatase; pfam00857 216592005683 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216592005684 catalytic triad [active] 216592005685 conserved cis-peptide bond; other site 216592005686 HMMPfam hit to PF00857, Isochorismatase family, score 2.8e-101 216592005687 pyrimidine utilization protein A; Region: RutA; TIGR03612 216592005688 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216592005689 active site 216592005690 dimer interface [polypeptide binding]; other site 216592005691 non-prolyl cis peptide bond; other site 216592005692 insertion regions; other site 216592005693 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216592005694 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 0.00027 216592005695 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 216592005696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592005697 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 216592005698 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.9e-18 216592005699 Predicted helix-turn-helix motif with score 1460.000, SD 4.16 at aa 39-60, sequence TRLEQIAELAGVSKTNLLYYFP 216592005700 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 216592005701 Predicted transcriptional regulator [Transcription]; Region: COG3905 216592005702 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 216592005703 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 216592005704 Glutamate binding site [chemical binding]; other site 216592005705 NAD binding site [chemical binding]; other site 216592005706 catalytic residues [active] 216592005707 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 6.5e-91 216592005708 PS00070 Aldehyde dehydrogenases cysteine active site. 216592005709 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592005710 HMMPfam hit to PF01619, Proline dehydrogenase, score 4.1e-193 216592005711 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 216592005712 Na binding site [ion binding]; other site 216592005713 12 probable transmembrane helices predicted for EC042_1090 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-255, 275-297, 329-351, 372-391, 401-423, 428-450 and 455-473 216592005714 HMMPfam hit to PF00474, Sodium:solute symporter family, score 4.2e-222 216592005715 PS00456 Sodium:solute symporter family signature 1. 216592005716 PS00457 Sodium:solute symporter family signature 2. 216592005717 Predicted helix-turn-helix motif with score 1317.000, SD 3.67 at aa 329-350, sequence GYLEKWCKKRNLSRTTARNYLK 216592005718 FTR1 family protein; Region: TIGR00145 216592005719 HMMPfam hit to PF03239, Iron permease FTR1 family, score 3.2e-110 216592005720 7 probable transmembrane helices predicted for EC042_1093 by TMHMM2.0 at aa 10-29, 36-58, 73-92, 122-144, 154-176, 183-205 and 251-273 216592005721 PS00435 Peroxidases proximal heme-ligand signature. 216592005722 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 216592005723 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 216592005724 Imelysin; Region: Peptidase_M75; pfam09375 216592005725 Signal peptide predicted for EC042_1094 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 26 and 27 216592005726 HMMPfam hit to PF04302, Protein of unknown function (DUF451), score 8.3e-179 216592005727 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 216592005728 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 216592005729 Signal peptide predicted for EC042_1095 by SignalP 2.0 HMM (Signal peptide probability 0.839) with cleavage site probability 0.838 between residues 35 and 36 216592005730 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005731 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 3e-198 216592005732 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216592005733 hypothetical protein; Provisional; Region: PRK10536 216592005734 HMMPfam hit to PF02562, PhoH-like protein, score 2.2e-143 216592005735 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005736 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 216592005737 Signal peptide predicted for EC042_1097 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.969 between residues 21 and 22 216592005738 1 probable transmembrane helix predicted for EC042_1097 by TMHMM2.0 at aa 4-21 216592005739 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 216592005740 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 216592005741 putative ligand binding site [chemical binding]; other site 216592005742 NAD binding site [chemical binding]; other site 216592005743 dimerization interface [polypeptide binding]; other site 216592005744 catalytic site [active] 216592005745 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.4e-16 216592005746 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216592005747 putative hydrolase; Validated; Region: PRK09248 216592005748 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 216592005749 active site 216592005750 HMMPfam hit to PF02231, PHP domain N-terminal region, score 2.1e-23 216592005751 HMMPfam hit to PF02811, PHP domain C-terminal region, score 2e-15 216592005752 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 216592005753 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 2.7e-48 216592005754 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 216592005755 Signal peptide predicted for EC042_1101 by SignalP 2.0 HMM (Signal peptide probability 0.716) with cleavage site probability 0.431 between residues 57 and 58 216592005756 6 probable transmembrane helices predicted for EC042_1101 by TMHMM2.0 at aa 7-29, 33-55, 62-84, 88-110, 115-134 and 139-161 216592005757 HMMPfam hit to PF06496, Protein of unknown function (DUF1097), score 5.8e-97 216592005758 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 216592005759 HMMPfam hit to PF03783, Curli production assembly/transport componen, score 7.2e-118 216592005760 Signal peptide predicted for EC042_1102 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.688 between residues 24 and 25 216592005761 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005762 curli assembly protein CsgF; Provisional; Region: PRK10050 216592005763 1 probable transmembrane helix predicted for EC042_1103 by TMHMM2.0 at aa 7-26 216592005764 Signal peptide predicted for EC042_1103 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 19 and 20 216592005765 curli assembly protein CsgE; Provisional; Region: PRK10386 216592005766 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216592005767 Signal peptide predicted for EC042_1104 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.956 between residues 22 and 23 216592005768 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 216592005769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592005770 DNA binding residues [nucleotide binding] 216592005771 dimerization interface [polypeptide binding]; other site 216592005772 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 5.1e-21 216592005773 PS00622 Bacterial regulatory proteins, luxR family signature. 216592005774 1 probable transmembrane helix predicted for EC042_1107 by TMHMM2.0 at aa 13-30 216592005775 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 216592005776 Curlin associated repeat; Region: Curlin_rpt; pfam07012 216592005777 Curlin associated repeat; Region: Curlin_rpt; pfam07012 216592005778 Signal peptide predicted for EC042_1108 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.896 between residues 30 and 31 216592005779 1 probable transmembrane helix predicted for EC042_1108 by TMHMM2.0 at aa 15-37 216592005780 HMMPfam hit to PF07012, Curlin associated repeat, score 4.5e-12 216592005781 HMMPfam hit to PF07012, Curlin associated repeat, score 3.6e-09 216592005782 major curlin subunit; Provisional; Region: csgA; PRK10051 216592005783 Curlin associated repeat; Region: Curlin_rpt; pfam07012 216592005784 Curlin associated repeat; Region: Curlin_rpt; pfam07012 216592005785 Signal peptide predicted for EC042_1109 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 216592005786 HMMPfam hit to PF07012, Curlin associated repeat, score 8.8e-13 216592005787 HMMPfam hit to PF07012, Curlin associated repeat, score 1.1e-13 216592005788 HMMPfam hit to PF07012, Curlin associated repeat, score 1.4 216592005789 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 216592005790 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592005791 Signal peptide predicted for EC042_1111 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.486 between residues 22 and 23 216592005792 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 216592005793 putative ADP-ribose binding site [chemical binding]; other site 216592005794 putative active site [active] 216592005795 HMMPfam hit to PF01661, Appr-1-p processing enzyme family, score 1.3e-64 216592005796 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 216592005797 PLD-like domain; Region: PLDc_2; pfam13091 216592005798 putative active site [active] 216592005799 catalytic site [active] 216592005800 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 216592005801 PLD-like domain; Region: PLDc_2; pfam13091 216592005802 putative active site [active] 216592005803 catalytic site [active] 216592005804 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.044 216592005805 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 8e-05 216592005806 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 216592005807 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216592005808 HMMPfam hit to PF01757, Acyltransferase family, score 5.7e-68 216592005809 10 probable transmembrane helices predicted for EC042_1114 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 136-158, 179-198, 213-235, 242-261, 276-295, 308-330 and 334-356 216592005810 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 216592005811 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 216592005812 Signal peptide predicted for EC042_1117 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.795 between residues 28 and 29 216592005813 1 probable transmembrane helix predicted for EC042_1117 by TMHMM2.0 at aa 12-31 216592005814 HMMPfam hit to PF04349, Periplasmic glucan biosynthesis protein, Mdo, score 0 216592005815 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216592005816 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 216592005817 Ligand binding site; other site 216592005818 DXD motif; other site 216592005819 6 probable transmembrane helices predicted for EC042_1118 by TMHMM2.0 at aa 149-166, 204-226, 522-544, 578-600, 613-635 and 690-712 216592005820 HMMPfam hit to PF00535, Glycosyl transferase, score 1.8e-11 216592005821 PS00213 Lipocalin signature. 216592005822 lipoprotein; Provisional; Region: PRK10175 216592005823 Signal peptide predicted for EC042_1119 by SignalP 2.0 HMM (Signal peptide probability 0.816) with cleavage site probability 0.414 between residues 21 and 22 216592005824 HMMPfam hit to PF07119, Protein of unknown function (DUF1375), score 5.9e-40 216592005825 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005826 secY/secA suppressor protein; Provisional; Region: PRK11467 216592005827 drug efflux system protein MdtG; Provisional; Region: PRK09874 216592005828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592005829 putative substrate translocation pore; other site 216592005830 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4e-05 216592005831 10 probable transmembrane helices predicted for EC042_1121 by TMHMM2.0 at aa 19-41, 56-78, 85-107, 111-130, 142-164, 174-193, 224-246, 256-278, 290-312 and 374-396 216592005832 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-48 216592005833 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216592005834 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216592005835 putative acyl-acceptor binding pocket; other site 216592005836 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 5.9e-169 216592005837 1 probable transmembrane helix predicted for EC042_1122 by TMHMM2.0 at aa 37-59 216592005838 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 216592005839 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 216592005840 active site residue [active] 216592005841 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005842 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.6e-29 216592005843 hypothetical protein; Provisional; Region: PRK03757 216592005844 HMMPfam hit to PF04264, YceI like family, score 1.7e-85 216592005845 Signal peptide predicted for EC042_1124 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 216592005846 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 216592005847 HMMPfam hit to PF01292, Cytochrome b561 family, score 8.4e-71 216592005848 4 probable transmembrane helices predicted for EC042_1125 by TMHMM2.0 at aa 43-65, 80-97, 117-139 and 172-194 216592005849 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 216592005850 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216592005851 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 5.2e-64 216592005852 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 216592005853 DNA damage-inducible protein I; Provisional; Region: PRK10597 216592005854 HMMPfam hit to PF06183, DinI-like family, score 5.4e-38 216592005855 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 216592005856 active site 216592005857 substrate binding pocket [chemical binding]; other site 216592005858 dimer interface [polypeptide binding]; other site 216592005859 HMMPfam hit to PF01979, Amidohydrolase family, score 1.6e-78 216592005860 PS00483 Dihydroorotase signature 2. 216592005861 PS00482 Dihydroorotase signature 1. 216592005862 lipoprotein; Provisional; Region: PRK10598 216592005863 HMMPfam hit to PF07273, Protein of unknown function (DUF1439), score 4.8e-137 216592005864 1 probable transmembrane helix predicted for EC042_1130 by TMHMM2.0 at aa 23-45 216592005865 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005866 glutaredoxin 2; Provisional; Region: PRK10387 216592005867 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 216592005868 C-terminal domain interface [polypeptide binding]; other site 216592005869 GSH binding site (G-site) [chemical binding]; other site 216592005870 catalytic residues [active] 216592005871 putative dimer interface [polypeptide binding]; other site 216592005872 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 216592005873 N-terminal domain interface [polypeptide binding]; other site 216592005874 HMMPfam hit to PF04399, Glutaredoxin 2, C terminal domain, score 5.2e-90 216592005875 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 2.6e-05 216592005876 PS00195 Glutaredoxin active site. 216592005877 multidrug resistance protein MdtH; Provisional; Region: PRK11646 216592005878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592005879 putative substrate translocation pore; other site 216592005880 11 probable transmembrane helices predicted for EC042_1132 by TMHMM2.0 at aa 23-45, 52-69, 109-126, 146-168, 173-195, 220-242, 257-274, 287-306, 310-332, 345-367 and 377-396 216592005881 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-44 216592005882 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 216592005883 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216592005884 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-12 216592005885 hypothetical protein; Provisional; Region: PRK11239 216592005886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 216592005887 HMMPfam hit to PF04337, Protein of unknown function, DUF480, score 9.8e-139 216592005888 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216592005889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216592005890 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216592005891 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 1.1e-36 216592005892 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 2.9e-10 216592005893 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 216592005894 MviN-like protein; Region: MVIN; pfam03023 216592005895 14 probable transmembrane helices predicted for EC042_1136 by TMHMM2.0 at aa 7-29, 39-58, 95-117, 146-165, 172-194, 199-216, 250-272, 287-309, 329-351, 366-388, 395-417, 421-440, 457-479 and 494-516 216592005896 HMMPfam hit to PF03023, MviN-like protein, score 7.7e-225 216592005897 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 216592005898 HMMPfam hit to PF05130, FlgN protein, score 7.5e-76 216592005899 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 216592005900 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 1.6e-29 216592005901 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 216592005902 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 216592005903 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 216592005904 HMMPfam hit to PF03240, FlgA family, score 2.9e-80 216592005905 Signal peptide predicted for EC042_1139 by SignalP 2.0 HMM (Signal peptide probability 0.687) with cleavage site probability 0.459 between residues 21 and 22 216592005906 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 216592005907 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 216592005908 HMMPfam hit to PF00460, Flagella basal body rod protein, score 9.7e-13 216592005909 PS00588 Flagella basal body rod proteins signature. 216592005910 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 216592005911 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592005912 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592005913 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1e-11 216592005914 PS00588 Flagella basal body rod proteins signature. 216592005915 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 9.8e-08 216592005916 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 216592005917 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 216592005918 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 216592005919 HMMPfam hit to PF03963, Flagellar hook capping protein, score 6.6e-61 216592005920 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 216592005921 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592005922 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 216592005923 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592005924 HMMPfam hit to PF00460, Flagella basal body rod protein, score 7.8e-13 216592005925 PS00588 Flagella basal body rod proteins signature. 216592005926 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 1.2e-29 216592005927 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 6.2e-20 216592005928 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 216592005929 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592005930 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 216592005931 HMMPfam hit to PF00460, Flagella basal body rod protein, score 3.4e-11 216592005932 PS00588 Flagella basal body rod proteins signature. 216592005933 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.00061 216592005934 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 216592005935 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592005936 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216592005937 HMMPfam hit to PF00460, Flagella basal body rod protein, score 4.9e-15 216592005938 PS00588 Flagella basal body rod proteins signature. 216592005939 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1.4e-19 216592005940 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 216592005941 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 216592005942 Signal peptide predicted for EC042_1146 by SignalP 2.0 HMM (Signal peptide probability 0.979) with cleavage site probability 0.639 between residues 33 and 34 216592005943 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592005944 HMMPfam hit to PF02107, Flagellar L-ring protein, score 3e-112 216592005945 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 216592005946 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 216592005947 Signal peptide predicted for EC042_1147 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.969 between residues 20 and 21 216592005948 HMMPfam hit to PF02119, Flagellar P-ring protein, score 2.4e-235 216592005949 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 216592005950 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 216592005951 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 216592005952 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglu, score 7.8e-71 216592005953 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 216592005954 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216592005955 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 216592005956 HMMPfam hit to PF00460, Flagella basal body rod protein, score 2e-06 216592005957 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 5.9e-16 216592005958 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 216592005959 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216592005960 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.5e-49 216592005961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592005962 Coenzyme A binding pocket [chemical binding]; other site 216592005963 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.5e-07 216592005964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 216592005965 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 216592005966 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216592005967 homodimer interface [polypeptide binding]; other site 216592005968 oligonucleotide binding site [chemical binding]; other site 216592005969 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 216592005970 HMMPfam hit to PF00575, S1 RNA binding domain, score 6.1e-19 216592005971 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 216592005972 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592005973 RNA binding surface [nucleotide binding]; other site 216592005974 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216592005975 active site 216592005976 HMMPfam hit to PF01479, S4 domain, score 3.2e-11 216592005977 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.8e-60 216592005978 PS01129 Rlu family of pseudouridine synthase signature. 216592005979 HTH-like domain; Region: HTH_21; pfam13276 216592005980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592005981 Integrase core domain; Region: rve; pfam00665 216592005982 Integrase core domain; Region: rve_2; pfam13333 216592005983 HMMPfam hit to PF00665, Integrase core domain, score 5.7e-45 216592005984 PS00017 ATP/GTP-binding site motif A (P-loop). 216592005985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592005986 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592005987 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592005988 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 23-44, sequence AGIISTAKLFQLSHTSLSHWIN 216592005989 Maf-like protein; Region: Maf; pfam02545 216592005990 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216592005991 active site 216592005992 dimer interface [polypeptide binding]; other site 216592005993 HMMPfam hit to PF02545, Maf-like protein, score 3.7e-99 216592005994 hypothetical protein; Provisional; Region: PRK11193 216592005995 HMMPfam hit to PF02620, Uncharacterized ACR, COG1399, score 1.4e-57 216592005996 putative phosphate acyltransferase; Provisional; Region: PRK05331 216592005997 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 2.9e-190 216592005998 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216592005999 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216592006000 dimer interface [polypeptide binding]; other site 216592006001 active site 216592006002 CoA binding pocket [chemical binding]; other site 216592006003 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216592006004 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216592006005 HMMPfam hit to PF00698, Acyl transferase domain, score 2.8e-12 216592006006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216592006007 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216592006008 NAD(P) binding site [chemical binding]; other site 216592006009 homotetramer interface [polypeptide binding]; other site 216592006010 homodimer interface [polypeptide binding]; other site 216592006011 active site 216592006012 HMMPfam hit to PF00106, short chain dehydrogenase, score 2.6e-93 216592006013 PS00061 Short-chain dehydrogenases/reductases family signature. 216592006014 acyl carrier protein; Provisional; Region: acpP; PRK00982 216592006015 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.6e-24 216592006016 PS00012 Phosphopantetheine attachment site. 216592006017 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592006018 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 216592006019 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216592006020 dimer interface [polypeptide binding]; other site 216592006021 active site 216592006022 Signal peptide predicted for EC042_1165 by SignalP 2.0 HMM (Signal peptide probability 0.915) with cleavage site probability 0.805 between residues 20 and 21 216592006023 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 3.3e-84 216592006024 PS00606 Beta-ketoacyl synthases active site. 216592006025 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 5.4e-73 216592006026 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216592006027 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 216592006028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592006029 catalytic residue [active] 216592006030 HMMPfam hit to PF01063, Aminotransferase class IV, score 3e-90 216592006031 PS00770 Aminotransferases class-IV signature. 216592006032 conserved hypothetical protein, YceG family; Region: TIGR00247 216592006033 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 216592006034 dimerization interface [polypeptide binding]; other site 216592006035 Signal peptide predicted for EC042_1167 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.329 between residues 20 and 21 216592006036 1 probable transmembrane helix predicted for EC042_1167 by TMHMM2.0 at aa 5-24 216592006037 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 9.1e-155 216592006038 thymidylate kinase; Validated; Region: tmk; PRK00698 216592006039 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 216592006040 TMP-binding site; other site 216592006041 ATP-binding site [chemical binding]; other site 216592006042 HMMPfam hit to PF02223, Thymidylate kinase, score 5e-86 216592006043 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006044 PS01331 Thymidylate kinase signature. 216592006045 DNA polymerase III subunit delta'; Validated; Region: PRK07993 216592006046 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 216592006047 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216592006048 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 216592006049 active site 216592006050 HMMPfam hit to PF01026, TatD related DNase, score 2.7e-122 216592006051 PS01137 Uncharacterized protein family UPF0006 signature 1. 216592006052 PS01091 Uncharacterized protein family UPF0006 signature 3. 216592006053 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 216592006054 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 216592006055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592006056 active site turn [active] 216592006057 phosphorylation site [posttranslational modification] 216592006058 Signal peptide predicted for EC042_1171 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.390 between residues 49 and 50 216592006059 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.1e-106 216592006060 10 probable transmembrane helices predicted for EC042_1171 by TMHMM2.0 at aa 21-43, 53-72, 79-101, 116-133, 154-176, 191-213, 250-272, 282-304, 309-331 and 354-376 216592006061 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.3e-18 216592006062 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592006063 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 216592006064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592006065 N-terminal plug; other site 216592006066 ligand-binding site [chemical binding]; other site 216592006067 HMMPfam hit to PF00593, TonB dependent receptor, score 1.4e-27 216592006068 PS01156 TonB-dependent receptor proteins signature 2. 216592006069 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.8e-19 216592006070 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 216592006071 nucleotide binding site/active site [active] 216592006072 HIT family signature motif; other site 216592006073 catalytic residue [active] 216592006074 HMMPfam hit to PF01230, HIT domain, score 4.1e-56 216592006075 PS00892 HIT family signature. 216592006076 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 216592006077 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 216592006078 putative dimer interface [polypeptide binding]; other site 216592006079 HMMPfam hit to PF07233, Protein of unknown function (DUF1425), score 6e-69 216592006080 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006081 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 216592006082 Signal peptide predicted for EC042_1175 by SignalP 2.0 HMM (Signal peptide probability 0.982) with cleavage site probability 0.347 between residues 24 and 25 216592006083 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006084 thiamine kinase; Region: ycfN_thiK; TIGR02721 216592006085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216592006086 active site 216592006087 substrate binding site [chemical binding]; other site 216592006088 ATP binding site [chemical binding]; other site 216592006089 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 1.9e-26 216592006090 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216592006091 beta-hexosaminidase; Provisional; Region: PRK05337 216592006092 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 5e-89 216592006093 PS00775 Glycosyl hydrolases family 3 active site. 216592006094 hypothetical protein; Provisional; Region: PRK04940 216592006095 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 7.7e-103 216592006096 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216592006097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592006098 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 5.3e-60 216592006099 hypothetical protein; Provisional; Region: PRK11280 216592006100 1 probable transmembrane helix predicted for EC042_1180 by TMHMM2.0 at aa 19-41 216592006101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216592006102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592006103 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8.1e-15 216592006104 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592006105 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 3.4e-23 216592006106 Signal peptide predicted for EC042_1182 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 22 and 23 216592006107 L,D-transpeptidase; Provisional; Region: PRK10260 216592006108 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592006109 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592006110 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 3.1e-67 216592006111 HMMPfam hit to PF01476, LysM domain, score 9.6e-08 216592006112 Signal peptide predicted for EC042_1183 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.943 between residues 29 and 30 216592006113 transcription-repair coupling factor; Provisional; Region: PRK10689 216592006114 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 216592006115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592006116 ATP binding site [chemical binding]; other site 216592006117 putative Mg++ binding site [ion binding]; other site 216592006118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592006119 nucleotide binding region [chemical binding]; other site 216592006120 ATP-binding site [chemical binding]; other site 216592006121 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 216592006122 HMMPfam hit to PF03461, TRCF domain, score 3.1e-57 216592006123 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.9e-20 216592006124 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.7e-42 216592006125 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 8.3e-08 216592006126 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006127 HMMPfam hit to PF02559, CarD-like/TRCF domain, score 1.2e-49 216592006128 Predicted membrane protein [Function unknown]; Region: COG4763 216592006129 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216592006130 HMMPfam hit to PF01757, Acyltransferase family, score 9.2e-60 216592006131 8 probable transmembrane helices predicted for EC042_1185 by TMHMM2.0 at aa 13-32, 47-69, 90-112, 134-156, 163-185, 226-248, 269-288 and 308-330 216592006132 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 216592006133 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216592006134 FtsX-like permease family; Region: FtsX; pfam02687 216592006135 4 probable transmembrane helices predicted for EC042_1186 by TMHMM2.0 at aa 25-47, 266-288, 318-340 and 360-382 216592006136 HMMPfam hit to PF02687, Predicted permease, score 1.4e-46 216592006137 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 216592006138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216592006139 Walker A/P-loop; other site 216592006140 ATP binding site [chemical binding]; other site 216592006141 Q-loop/lid; other site 216592006142 ABC transporter signature motif; other site 216592006143 Walker B; other site 216592006144 D-loop; other site 216592006145 H-loop/switch region; other site 216592006146 HMMPfam hit to PF00005, ABC transporter, score 1.5e-65 216592006147 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006148 PS00211 ABC transporters family signature. 216592006149 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 216592006150 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216592006151 FtsX-like permease family; Region: FtsX; pfam02687 216592006152 4 probable transmembrane helices predicted for EC042_1188 by TMHMM2.0 at aa 21-43, 270-292, 319-341 and 375-397 216592006153 HMMPfam hit to PF02687, Predicted permease, score 3.2e-54 216592006154 PS00027 'Homeobox' domain signature. 216592006155 fructokinase; Reviewed; Region: PRK09557 216592006156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592006157 nucleotide binding site [chemical binding]; other site 216592006158 HMMPfam hit to PF00480, ROK family, score 2e-55 216592006159 PS01125 ROK family signature. 216592006160 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006161 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592006162 NAD-dependent deacetylase; Provisional; Region: PRK00481 216592006163 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 216592006164 NAD+ binding site [chemical binding]; other site 216592006165 substrate binding site [chemical binding]; other site 216592006166 Zn binding site [ion binding]; other site 216592006167 HMMPfam hit to PF02146, Sir2 family, score 1.2e-83 216592006168 Repair protein; Region: Repair_PSII; cl01535 216592006169 4 probable transmembrane helices predicted for EC042_1191 by TMHMM2.0 at aa 5-27, 178-200, 207-229 and 234-256 216592006170 Signal peptide predicted for EC042_1191 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.978 between residues 20 and 21 216592006171 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 216592006172 2 probable transmembrane helices predicted for EC042_1192 by TMHMM2.0 at aa 21-43 and 134-156 216592006173 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 216592006174 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 216592006175 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.1e-13 216592006176 Signal peptide predicted for EC042_1193 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 216592006177 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216592006178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592006179 dimer interface [polypeptide binding]; other site 216592006180 conserved gate region; other site 216592006181 putative PBP binding loops; other site 216592006182 ABC-ATPase subunit interface; other site 216592006183 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.3e-15 216592006184 6 probable transmembrane helices predicted for EC042_1194 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252 216592006185 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592006186 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216592006187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592006188 dimer interface [polypeptide binding]; other site 216592006189 conserved gate region; other site 216592006190 putative PBP binding loops; other site 216592006191 ABC-ATPase subunit interface; other site 216592006192 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.4e-14 216592006193 6 probable transmembrane helices predicted for EC042_1195 by TMHMM2.0 at aa 9-31, 69-91, 98-120, 151-173, 194-216 and 250-272 216592006194 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592006195 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 216592006196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592006197 Walker A/P-loop; other site 216592006198 ATP binding site [chemical binding]; other site 216592006199 Q-loop/lid; other site 216592006200 ABC transporter signature motif; other site 216592006201 Walker B; other site 216592006202 D-loop; other site 216592006203 H-loop/switch region; other site 216592006204 TOBE domain; Region: TOBE_2; pfam08402 216592006205 HMMPfam hit to PF00005, ABC transporter, score 1.7e-68 216592006206 PS00211 ABC transporters family signature. 216592006207 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006208 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 216592006209 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 216592006210 metal binding site [ion binding]; metal-binding site 216592006211 dimer interface [polypeptide binding]; other site 216592006212 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216592006213 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 216592006214 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.3e-26 216592006215 Uncharacterized conserved protein [Function unknown]; Region: COG2850 216592006216 Cupin-like domain; Region: Cupin_8; pfam13621 216592006217 sensor protein PhoQ; Provisional; Region: PRK10815 216592006218 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 216592006219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 216592006220 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 216592006221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592006222 ATP binding site [chemical binding]; other site 216592006223 Mg2+ binding site [ion binding]; other site 216592006224 G-X-G motif; other site 216592006225 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.7e-27 216592006226 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.00033 216592006227 HMMPfam hit to PF00672, HAMP domain, score 3.6e-07 216592006228 2 probable transmembrane helices predicted for EC042_1200 by TMHMM2.0 at aa 20-42 and 194-216 216592006229 Signal peptide predicted for EC042_1200 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.341 between residues 31 and 32 216592006230 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 216592006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592006232 active site 216592006233 phosphorylation site [posttranslational modification] 216592006234 intermolecular recognition site; other site 216592006235 dimerization interface [polypeptide binding]; other site 216592006236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592006237 DNA binding site [nucleotide binding] 216592006238 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 6e-16 216592006239 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.4e-33 216592006240 adenylosuccinate lyase; Provisional; Region: PRK09285 216592006241 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 216592006242 tetramer interface [polypeptide binding]; other site 216592006243 active site 216592006244 HMMPfam hit to PF00206, Lyase, score 7.3e-118 216592006245 PS00163 Fumarate lyases signature. 216592006246 putative lysogenization regulator; Reviewed; Region: PRK00218 216592006247 HMMPfam hit to PF04356, Protein of unknown function (DUF489), score 4.8e-148 216592006248 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 216592006249 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 216592006250 HMMPfam hit to PF03054, tRNA methyl transferase, score 1.2e-235 216592006251 PS00070 Aldehyde dehydrogenases cysteine active site. 216592006252 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 216592006253 nudix motif; other site 216592006254 HMMPfam hit to PF00293, NUDIX domain, score 6.3e-28 216592006255 PS00893 mutT domain signature. 216592006256 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 216592006257 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 216592006258 probable active site [active] 216592006259 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4.1e-23 216592006260 PS01149 Rsu family of pseudouridine synthase signature. 216592006261 isocitrate dehydrogenase; Validated; Region: PRK07362 216592006262 isocitrate dehydrogenase; Reviewed; Region: PRK07006 216592006263 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 6.7e-160 216592006264 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216592006265 anti-adapter protein IraM; Provisional; Region: PRK09919 216592006266 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 216592006267 HMMPfam hit to PF07166, Protein of unknown function (DUF1398), score 3e-99 216592006268 transcriptional regulator MirA; Provisional; Region: PRK15043 216592006269 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 216592006270 DNA binding residues [nucleotide binding] 216592006271 HMMPfam hit to PF00376, MerR family regulatory protein, score 3.4e-11 216592006272 PS00552 Bacterial regulatory proteins, merR family signature. 216592006273 Predicted helix-turn-helix motif with score 1971.000, SD 5.90 at aa 4-25, sequence YSIGDVAERCGINPVTLRAWQR 216592006274 Sensors of blue-light using FAD; Region: BLUF; smart01034 216592006275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592006276 HMMPfam hit to PF00563, EAL domain, score 3e-61 216592006277 HMMPfam hit to PF04940, Sensors of blue-light using FAD, score 2.3e-68 216592006278 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 216592006279 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 216592006281 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216592006282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592006283 2 probable transmembrane helices predicted for EC042_1215 by TMHMM2.0 at aa 20-42 and 235-253 216592006284 HMMPfam hit to PF00563, EAL domain, score 3.2e-111 216592006285 2 probable transmembrane helices predicted for EC042_1216 by TMHMM2.0 at aa 21-43 and 48-70 216592006286 ROD 216592006288 Signal peptide predicted for EC042_1218 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 23 and 24 216592006289 HMMPfam hit to PF03212, Pertactin, score 0.00068 216592006290 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.3e-39 216592006291 Signal peptide predicted for EC042_1220 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 216592006292 2 probable transmembrane helices predicted for EC042_1221 by TMHMM2.0 at aa 5-22 and 37-59 216592006293 Signal peptide predicted for EC042_1221 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 216592006294 1 probable transmembrane helix predicted for EC042_1222 by TMHMM2.0 at aa 4-26 216592006295 Autotransporter beta-domain; Region: Autotransporter; smart00869 216592006296 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 216592006297 HMMPfam hit to PF03776, Septum formation topological specificity fac, score 1.1e-53 216592006298 cell division inhibitor MinD; Provisional; Region: PRK10818 216592006299 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 216592006300 Switch I; other site 216592006301 Switch II; other site 216592006302 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 5.2e-27 216592006303 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006304 septum formation inhibitor; Reviewed; Region: minC; PRK03511 216592006305 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 216592006306 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 216592006307 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 1e-65 216592006308 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 6.1e-58 216592006309 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 216592006310 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 216592006311 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 216592006312 HMMPfam hit to PF04151, Bacterial pre-peptidase C-terminal domain, score 1.3e-12 216592006313 Signal peptide predicted for EC042_1227 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.893 between residues 22 and 23 216592006314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 216592006315 HMMPfam hit to PF05166, Family of unknown function (DUF709), score 3.2e-60 216592006316 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216592006317 hypothetical protein; Provisional; Region: PRK10691 216592006318 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 6.4e-92 216592006319 hypothetical protein; Provisional; Region: PRK05170 216592006320 HMMPfam hit to PF05779, Bacterial protein of unknown function (DUF83, score 6.3e-109 216592006321 hemolysin E; Provisional; Region: hlyE; PRK11376 216592006322 HMMPfam hit to PF06109, Haemolysin E (HlyE), score 4.1e-243 216592006323 1 probable transmembrane helix predicted for EC042_1231 by TMHMM2.0 at aa 183-205 216592006324 PS00136 Serine proteases, subtilase family, aspartic acid active site. 216592006325 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 216592006326 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216592006327 Catalytic site [active] 216592006328 HMMPfam hit to PF00717, Peptidase S24-like, score 2.4e-18 216592006329 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 216592006330 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 216592006331 active site 216592006332 DNA binding site [nucleotide binding] 216592006333 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 216592006334 HMMPfam hit to PF00817, impB/mucB/samB family, score 1.4e-173 216592006335 disulfide bond formation protein B; Provisional; Region: PRK01749 216592006336 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 8.7e-89 216592006337 4 probable transmembrane helices predicted for EC042_1234 by TMHMM2.0 at aa 13-32, 42-64, 71-89 and 145-162 216592006338 Signal peptide predicted for EC042_1234 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.915 between residues 24 and 25 216592006339 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 216592006340 transmembrane helices; other site 216592006341 HMMPfam hit to PF06450, Bacterial Na+/H+ antiporter B (NhaB), score 0 216592006342 11 probable transmembrane helices predicted for EC042_1235 by TMHMM2.0 at aa 44-66, 81-100, 113-135, 155-177, 215-237, 257-279, 317-349, 364-386, 407-429, 471-490 and 497-519 216592006343 fatty acid metabolism regulator; Provisional; Region: PRK04984 216592006344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592006345 DNA-binding site [nucleotide binding]; DNA binding site 216592006346 FadR C-terminal domain; Region: FadR_C; pfam07840 216592006347 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 5.4e-24 216592006348 PS00043 Bacterial regulatory proteins, gntR family signature. 216592006349 SpoVR family protein; Provisional; Region: PRK11767 216592006350 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 216592006351 HMMPfam hit to PF04293, SpoVR like protein, score 0 216592006352 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 216592006353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592006354 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.9e-107 216592006355 alanine racemase; Reviewed; Region: dadX; PRK03646 216592006356 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 216592006357 active site 216592006358 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592006359 substrate binding site [chemical binding]; other site 216592006360 catalytic residues [active] 216592006361 dimer interface [polypeptide binding]; other site 216592006362 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 4.6e-89 216592006363 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 216592006364 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 9.8e-66 216592006365 Leucine rich repeat; Region: LRR_8; pfam13855 216592006366 HMMPfam hit to PF00560, Leucine Rich Repeat, score 1.7 216592006367 HMMPfam hit to PF00560, Leucine Rich Repeat, score 6 216592006368 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 216592006369 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216592006370 TrkA-C domain; Region: TrkA_C; pfam02080 216592006371 Transporter associated domain; Region: CorC_HlyC; smart01091 216592006372 HMMPfam hit to PF03471, Transporter associated domain, score 2.3e-22 216592006373 HMMPfam hit to PF02080, TrkA-C domain, score 3.7e-11 216592006374 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 4e-99 216592006375 11 probable transmembrane helices predicted for EC042_1242 by TMHMM2.0 at aa 4-26, 31-53, 57-74, 87-109, 119-141, 195-217, 232-254, 267-289, 299-321, 334-356 and 361-383 216592006376 Signal peptide predicted for EC042_1242 by SignalP 2.0 HMM (Signal peptide probability 0.807) with cleavage site probability 0.186 between residues 29 and 30 216592006377 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 216592006378 dimer interface [polypeptide binding]; other site 216592006379 catalytic triad [active] 216592006380 HMMPfam hit to PF02016, LD-carboxypeptidase, score 1.1e-21 216592006381 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 216592006382 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592006383 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592006384 catalytic residue [active] 216592006385 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006386 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.6e-40 216592006387 PS00922 Prokaryotic transglycosylases signature. 216592006388 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 216592006389 Flagellar regulator YcgR; Region: YcgR; pfam07317 216592006390 PilZ domain; Region: PilZ; pfam07238 216592006391 HMMPfam hit to PF07317, YcgR protein, score 4.4e-196 216592006392 hypothetical protein; Provisional; Region: PRK10457 216592006393 3 probable transmembrane helices predicted for EC042_1246 by TMHMM2.0 at aa 10-31, 38-60 and 70-92 216592006394 HMMPfam hit to PF04226, Transglycosylase associated protein, score 1.6e-19 216592006395 Missing from the 2 ETEC strains, HS and K12. Carries TonB-dependent receptor and ABC transport system 216592006396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592006397 N-terminal plug; other site 216592006398 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216592006399 ligand-binding site [chemical binding]; other site 216592006400 HMMPfam hit to PF00593, TonB dependent receptor, score 6.6e-25 216592006401 PS01156 TonB-dependent receptor proteins signature 2. 216592006402 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.7e-18 216592006403 Signal peptide predicted for EC042_1247 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.954 between residues 22 and 23 216592006404 molybdenum transport protein ModD; Provisional; Region: PRK06096 216592006405 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 216592006406 dimerization interface [polypeptide binding]; other site 216592006407 active site 216592006408 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, C-t, score 2.3e-69 216592006409 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, N-t, score 1.1e-32 216592006410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592006411 S-adenosylmethionine binding site [chemical binding]; other site 216592006412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216592006413 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592006414 Walker A/P-loop; other site 216592006415 ATP binding site [chemical binding]; other site 216592006416 Q-loop/lid; other site 216592006417 ABC transporter signature motif; other site 216592006418 Walker B; other site 216592006419 D-loop; other site 216592006420 H-loop/switch region; other site 216592006421 HMMPfam hit to PF00005, ABC transporter, score 5e-47 216592006422 PS00211 ABC transporters family signature. 216592006423 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006424 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592006425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592006426 ABC-ATPase subunit interface; other site 216592006427 dimer interface [polypeptide binding]; other site 216592006428 putative PBP binding regions; other site 216592006429 9 probable transmembrane helices predicted for EC042_1251 by TMHMM2.0 at aa 7-29, 53-75, 88-105, 109-131, 143-165, 185-207, 233-255, 275-297 and 302-324 216592006430 HMMPfam hit to PF01032, FecCD transport family, score 3.9e-96 216592006431 Signal peptide predicted for EC042_1251 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.558 between residues 19 and 20 216592006432 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 216592006433 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 216592006434 putative metal binding site [ion binding]; other site 216592006435 HMMPfam hit to PF01497, Periplasmic binding protein, score 8.3e-06 216592006436 Predicted helix-turn-helix motif with score 1190.000, SD 3.24 at aa 220-241, sequence HNVAQIADRHGLTQVSMENLLR 216592006437 Signal peptide predicted for EC042_1252 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.982 between residues 25 and 26 216592006438 trehalase; Provisional; Region: treA; PRK13271 216592006439 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 216592006440 HMMPfam hit to PF01204, Trehalase, score 2.5e-277 216592006441 PS00928 Trehalase signature 2. 216592006442 PS00927 Trehalase signature 1. 216592006443 Signal peptide predicted for EC042_1253 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 31 and 32 216592006444 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 216592006445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 216592006446 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592006447 dimerization domain swap beta strand [polypeptide binding]; other site 216592006448 regulatory protein interface [polypeptide binding]; other site 216592006449 active site 216592006450 regulatory phosphorylation site [posttranslational modification]; other site 216592006451 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216592006452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592006453 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 1.6e-22 216592006454 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 6.3e-45 216592006455 HMMPfam hit to PF00381, PTS HPr component phosphorylation sit, score 7.3e-09 216592006456 HMMPfam hit to PF03610, PTS system fructose IIA component, score 4.8e-34 216592006457 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 216592006458 HMMPfam hit to PF02734, DAK2 domain, score 1.4e-84 216592006459 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 216592006460 Dak1 domain; Region: Dak1; pfam02733 216592006461 HMMPfam hit to PF02733, Dak1 domain, score 1e-221 216592006462 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 216592006463 PAS domain; Region: PAS; smart00091 216592006464 putative active site [active] 216592006465 heme pocket [chemical binding]; other site 216592006466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592006467 Walker A motif; other site 216592006468 ATP binding site [chemical binding]; other site 216592006469 Walker B motif; other site 216592006470 arginine finger; other site 216592006471 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592006472 HMMPfam hit to PF01590, GAF domain, score 2.9e-14 216592006473 HMMPfam hit to PF00989, PAS domain, score 1.3e-07 216592006474 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1e-33 216592006475 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592006476 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592006477 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 9.6e-15 216592006478 Predicted helix-turn-helix motif with score 1284.000, SD 3.56 at aa 608-629, sequence GRIQEMSALLGIGRTTLWRKMK 216592006479 Partially present in 0157, absent in Uropathogenic, regulator and putative adhesion and penetration protein, in O157 putative adhesion and penetration protein is present as a fragment and regulator is missing 216592006480 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 216592006481 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592006482 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592006483 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.2e-32 216592006484 HMMPfam hit to PF03212, Pertactin, score 1.6e-66 216592006485 Signal peptide predicted for EC042_1258 by SignalP 2.0 HMM (Signal peptide probability 0.699) with cleavage site probability 0.693 between residues 46 and 47 216592006486 1 probable transmembrane helix predicted for EC042_1259 by TMHMM2.0 at aa 25-47 216592006487 GTP-binding protein YchF; Reviewed; Region: PRK09601 216592006488 YchF GTPase; Region: YchF; cd01900 216592006489 G1 box; other site 216592006490 GTP/Mg2+ binding site [chemical binding]; other site 216592006491 Switch I region; other site 216592006492 G2 box; other site 216592006493 Switch II region; other site 216592006494 G3 box; other site 216592006495 G4 box; other site 216592006496 G5 box; other site 216592006497 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 216592006498 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 7.8e-61 216592006499 HMMPfam hit to PF01926, GTPase of unknown function, score 2.4e-32 216592006500 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006501 PS00443 Glutamine amidotransferases class-II active site. 216592006502 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 216592006503 putative active site [active] 216592006504 catalytic residue [active] 216592006505 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 1.9e-114 216592006506 PS00217 Sugar transport proteins signature 2. 216592006507 PS01196 Peptidyl-tRNA hydrolase signature 2. 216592006508 PS01195 Peptidyl-tRNA hydrolase signature 1. 216592006509 Signal peptide predicted for EC042_1261 by SignalP 2.0 HMM (Signal peptide probability 0.692) with cleavage site probability 0.687 between residues 17 and 18 216592006510 hypothetical protein; Provisional; Region: PRK10692 216592006511 Signal peptide predicted for EC042_1262 by SignalP 2.0 HMM (Signal peptide probability 0.935) with cleavage site probability 0.390 between residues 24 and 25 216592006512 2 probable transmembrane helices predicted for EC042_1262 by TMHMM2.0 at aa 7-29 and 42-64 216592006513 putative transporter; Provisional; Region: PRK11660 216592006514 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216592006515 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216592006516 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216592006517 HMMPfam hit to PF01740, STAS domain, score 6.1e-22 216592006518 HMMPfam hit to PF00916, Sulfate transporter family, score 9e-108 216592006519 11 probable transmembrane helices predicted for EC042_1263 by TMHMM2.0 at aa 34-56, 61-83, 103-125, 130-152, 177-199, 212-234, 278-300, 313-335, 345-367, 369-388 and 408-439 216592006520 PS01130 Sulfate transporters signature. 216592006521 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 216592006522 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 216592006523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592006524 active site 216592006525 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.9e-37 216592006526 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592006527 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 216592006528 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592006529 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 216592006530 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 216592006531 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 216592006532 HMMPfam hit to PF00288, GHMP kinases putative ATP-binding protei, score 1.1e-36 216592006533 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 216592006534 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 216592006535 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 4.6e-95 216592006536 Signal peptide predicted for EC042_1266 by SignalP 2.0 HMM (Signal peptide probability 0.731) with cleavage site probability 0.290 between residues 23 and 24 216592006537 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006538 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 216592006539 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 216592006540 tRNA; other site 216592006541 putative tRNA binding site [nucleotide binding]; other site 216592006542 putative NADP binding site [chemical binding]; other site 216592006543 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 216592006544 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase, N-terminal, score 8e-90 216592006545 PS00747 Glutamyl-tRNA reductase signature. 216592006546 HMMPfam hit to PF05200, Glutamyl-tRNAGlu reductase, NAD(P) bin, score 2.5e-86 216592006547 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase, dimerisati, score 1.2e-37 216592006548 peptide chain release factor 1; Validated; Region: prfA; PRK00591 216592006549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216592006550 RF-1 domain; Region: RF-1; pfam00472 216592006551 HMMPfam hit to PF03462, PCRF domain, score 6.5e-75 216592006552 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 7.6e-74 216592006553 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216592006554 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 216592006555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592006556 PS00092 N-6 Adenine-specific DNA methylases signature. 216592006557 hypothetical protein; Provisional; Region: PRK10278 216592006558 HMMPfam hit to PF04247, Invasion gene expression up-regulator, SirB, score 2.7e-71 216592006559 4 probable transmembrane helices predicted for EC042_1270 by TMHMM2.0 at aa 10-28, 40-59, 74-93 and 105-124 216592006560 hypothetical protein; Provisional; Region: PRK10941 216592006561 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 216592006562 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592006563 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 216592006564 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216592006565 HMMPfam hit to PF00793, DAHP synthetase I family, score 8.1e-120 216592006566 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592006567 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592006568 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 216592006569 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216592006570 12 probable transmembrane helices predicted for EC042_1273 by TMHMM2.0 at aa 4-23, 44-61, 65-87, 100-122, 137-156, 168-190, 195-217, 250-267, 287-309, 316-338, 348-370 and 375-394 216592006571 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 5.4e-15 216592006572 cation transport regulator; Reviewed; Region: chaB; PRK09582 216592006573 HMMPfam hit to PF06150, ChaB, score 2.7e-13 216592006574 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 216592006575 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216592006576 putative active site pocket [active] 216592006577 dimerization interface [polypeptide binding]; other site 216592006578 putative catalytic residue [active] 216592006579 HMMPfam hit to PF04752, ChaC-like protein, score 1.9e-99 216592006580 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 216592006581 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 2.4e-39 216592006582 putative invasin; Provisional; Region: PRK10177 216592006583 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 216592006584 Signal peptide predicted for EC042_1277 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 24 and 25 216592006585 transcriptional regulator NarL; Provisional; Region: PRK10651 216592006586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592006587 active site 216592006588 phosphorylation site [posttranslational modification] 216592006589 intermolecular recognition site; other site 216592006590 dimerization interface [polypeptide binding]; other site 216592006591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592006592 DNA binding residues [nucleotide binding] 216592006593 dimerization interface [polypeptide binding]; other site 216592006594 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3e-27 216592006595 PS00622 Bacterial regulatory proteins, luxR family signature. 216592006596 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 193-214, sequence LPNKMIARRLDITESTVKVHVK 216592006597 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-44 216592006598 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 216592006599 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 216592006600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592006601 dimerization interface [polypeptide binding]; other site 216592006602 Histidine kinase; Region: HisKA_3; pfam07730 216592006603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592006604 ATP binding site [chemical binding]; other site 216592006605 Mg2+ binding site [ion binding]; other site 216592006606 G-X-G motif; other site 216592006607 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.5e-23 216592006608 HMMPfam hit to PF07730, Histidine kinase, score 2.5e-22 216592006609 HMMPfam hit to PF00672, HAMP domain, score 3.9e-12 216592006610 2 probable transmembrane helices predicted for EC042_1279 by TMHMM2.0 at aa 15-37 and 152-174 216592006611 Signal peptide predicted for EC042_1279 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.587 between residues 33 and 34 216592006612 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 216592006613 12 probable transmembrane helices predicted for EC042_1281 by TMHMM2.0 at aa 40-62, 77-99, 106-125, 135-157, 178-200, 215-237, 258-280, 290-309, 322-341, 356-378, 406-423 and 438-460 216592006614 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.6e-15 216592006615 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 216592006616 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 216592006617 [4Fe-4S] binding site [ion binding]; other site 216592006618 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592006619 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592006620 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592006621 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 216592006622 molybdopterin cofactor binding site; other site 216592006623 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592006624 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.7e-185 216592006625 Predicted helix-turn-helix motif with score 1044.000, SD 2.74 at aa 503-524, sequence YTPAWAEQITGVSRSQIIRIAR 216592006626 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592006627 PS00037 Myb DNA-binding domain repeat signature 1. 216592006628 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 3.9e-43 216592006629 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592006630 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 216592006631 4Fe-4S binding domain; Region: Fer4; cl02805 216592006632 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.01 216592006633 PS00190 Cytochrome c family heme-binding site signature. 216592006634 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.011 216592006635 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 216592006636 HMMPfam hit to PF02613, Nitrate reductase delta subunit, score 2.2e-103 216592006637 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 216592006638 HMMPfam hit to PF02665, Nitrate reductase gamma subunit, score 1.8e-124 216592006639 5 probable transmembrane helices predicted for EC042_1285 by TMHMM2.0 at aa 4-26, 47-69, 89-108, 127-149 and 184-206 216592006640 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 216592006641 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216592006642 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216592006643 putative active site [active] 216592006644 putative substrate binding site [chemical binding]; other site 216592006645 putative cosubstrate binding site; other site 216592006646 catalytic site [active] 216592006647 HMMPfam hit to PF00551, Formyl transferase, score 6.5e-82 216592006648 HMMPfam hit to PF01842, ACT domain, score 1.8e-08 216592006649 hypothetical protein; Provisional; Region: PRK10279 216592006650 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 216592006651 active site 216592006652 nucleophile elbow; other site 216592006653 Signal peptide predicted for EC042_1289 by SignalP 2.0 HMM (Signal peptide probability 0.611) with cleavage site probability 0.145 between residues 17 and 18 216592006654 HMMPfam hit to PF01734, Patatin-like phospholipase, score 3.3e-57 216592006655 PS01237 Uncharacterized protein family UPF0028 signature. 216592006656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592006658 active site 216592006659 response regulator of RpoS; Provisional; Region: PRK10693 216592006660 phosphorylation site [posttranslational modification] 216592006661 intermolecular recognition site; other site 216592006662 dimerization interface [polypeptide binding]; other site 216592006663 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.9e-38 216592006664 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 216592006665 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 216592006666 active site 216592006667 tetramer interface; other site 216592006668 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.7e-12 216592006669 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006670 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 216592006671 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 216592006672 HMMPfam hit to PF00816, H-NS histone family, score 1.5e-49 216592006673 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006674 thymidine kinase; Provisional; Region: PRK04296 216592006675 HMMPfam hit to PF00265, Thymidine kinase, score 1.8e-106 216592006676 PS00603 Thymidine kinase cellular-type signature. 216592006677 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 216592006678 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 216592006679 putative catalytic cysteine [active] 216592006680 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 216592006681 putative active site [active] 216592006682 metal binding site [ion binding]; metal-binding site 216592006683 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 6.8e-237 216592006684 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592006685 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592006686 hypothetical protein; Provisional; Region: PRK11111 216592006687 HMMPfam hit to PF01914, MarC family integral membrane protein, score 2.3e-110 216592006688 6 probable transmembrane helices predicted for EC042_1295 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142, 146-168 and 189-211 216592006689 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 216592006690 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 216592006691 peptide binding site [polypeptide binding]; other site 216592006692 Signal peptide predicted for EC042_1297 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.992 between residues 26 and 27 216592006693 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 4.8e-81 216592006694 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592006695 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 216592006696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592006697 dimer interface [polypeptide binding]; other site 216592006698 conserved gate region; other site 216592006699 putative PBP binding loops; other site 216592006700 ABC-ATPase subunit interface; other site 216592006701 Signal peptide predicted for EC042_1298 by SignalP 2.0 HMM (Signal peptide probability 0.783) with cleavage site probability 0.336 between residues 32 and 33 216592006702 6 probable transmembrane helices predicted for EC042_1298 by TMHMM2.0 at aa 13-30, 102-121, 134-156, 166-188, 228-250 and 278-300 216592006703 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.7e-56 216592006704 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592006705 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 216592006706 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216592006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592006708 dimer interface [polypeptide binding]; other site 216592006709 conserved gate region; other site 216592006710 putative PBP binding loops; other site 216592006711 ABC-ATPase subunit interface; other site 216592006712 6 probable transmembrane helices predicted for EC042_1299 by TMHMM2.0 at aa 40-62, 103-125, 138-160, 164-183, 214-236 and 268-290 216592006713 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-40 216592006714 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592006715 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 216592006716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592006717 Walker A/P-loop; other site 216592006718 ATP binding site [chemical binding]; other site 216592006719 Q-loop/lid; other site 216592006720 ABC transporter signature motif; other site 216592006721 Walker B; other site 216592006722 D-loop; other site 216592006723 H-loop/switch region; other site 216592006724 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216592006725 HMMPfam hit to PF00005, ABC transporter, score 7.6e-60 216592006726 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006727 PS00211 ABC transporters family signature. 216592006728 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 216592006729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592006730 Walker A/P-loop; other site 216592006731 ATP binding site [chemical binding]; other site 216592006732 Q-loop/lid; other site 216592006733 ABC transporter signature motif; other site 216592006734 Walker B; other site 216592006735 D-loop; other site 216592006736 H-loop/switch region; other site 216592006737 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216592006738 HMMPfam hit to PF00005, ABC transporter, score 5.4e-64 216592006739 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006740 PS00211 ABC transporters family signature. 216592006741 dsDNA-mimic protein; Reviewed; Region: PRK05094 216592006742 HMMPfam hit to PF04269, Protein of unknown function, DUF440, score 4e-40 216592006743 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 216592006744 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 216592006745 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 216592006746 putative active site [active] 216592006747 catalytic site [active] 216592006748 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 216592006749 putative active site [active] 216592006750 catalytic site [active] 216592006751 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 5.1e-08 216592006752 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.7e-07 216592006753 2 probable transmembrane helices predicted for EC042_1303 by TMHMM2.0 at aa 10-29 and 36-58 216592006754 voltage-gated potassium channel; Provisional; Region: PRK10537 216592006755 Ion channel; Region: Ion_trans_2; pfam07885 216592006756 TrkA-N domain; Region: TrkA_N; pfam02254 216592006757 HMMPfam hit to PF02254, TrkA-N domain, score 4.4e-38 216592006758 7 probable transmembrane helices predicted for EC042_1304 by TMHMM2.0 at aa 29-51, 66-88, 93-112, 116-133, 140-162, 177-199 and 206-228 216592006759 HMMPfam hit to PF00520, Ion transport protein, score 0.02 216592006760 YciI-like protein; Reviewed; Region: PRK11370 216592006761 HMMPfam hit to PF03795, YCII-related domain, score 7.9e-48 216592006762 transport protein TonB; Provisional; Region: PRK10819 216592006763 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 216592006764 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 4.3e-18 216592006765 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216592006766 HMMPfam hit to PF03061, Thioesterase superfamily, score 3e-18 216592006767 intracellular septation protein A; Reviewed; Region: PRK00259 216592006768 HMMPfam hit to PF04279, Intracellular septation protein A, score 2.2e-119 216592006769 5 probable transmembrane helices predicted for EC042_1308 by TMHMM2.0 at aa 22-44, 51-68, 78-95, 119-141 and 151-170 216592006770 hypothetical protein; Provisional; Region: PRK02868 216592006771 HMMPfam hit to PF06790, Uncharacterised protein family (UPF0259), score 2.2e-163 216592006772 6 probable transmembrane helices predicted for EC042_1309 by TMHMM2.0 at aa 20-42, 87-109, 118-140, 144-166, 187-209 and 219-241 216592006773 Signal peptide predicted for EC042_1309 by SignalP 2.0 HMM (Signal peptide probability 0.922) with cleavage site probability 0.680 between residues 38 and 39 216592006774 outer membrane protein W; Provisional; Region: PRK10959 216592006775 Signal peptide predicted for EC042_1310 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 21 and 22 216592006776 HMMPfam hit to PF03922, OmpW family, score 3.4e-114 216592006777 prophage 2. Absent in Uropathogenic, divergent prophage in 0157, prophage, edge of rearrangement in 0157 (EDL, not Sakai), other edge see 042_ROD26 216592006778 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 216592006779 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216592006780 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 216592006781 dimer interface [polypeptide binding]; other site 216592006782 active site 216592006783 Int/Topo IB signature motif; other site 216592006784 HMMPfam hit to PF00589, Phage integrase family, score 7.8e-06 216592006785 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 216592006786 active site 216592006787 substrate binding site [chemical binding]; other site 216592006788 catalytic site [active] 216592006789 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 216592006790 HMMPfam hit to PF07358, Protein of unknown function (DUF1482), score 3.7e-35 216592006791 Ash protein family; Region: Phage_ASH; pfam10554 216592006792 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 216592006793 transcriptional repressor DicA; Reviewed; Region: PRK09706 216592006794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592006795 non-specific DNA binding site [nucleotide binding]; other site 216592006796 salt bridge; other site 216592006797 sequence-specific DNA binding site [nucleotide binding]; other site 216592006798 HMMPfam hit to PF01381, Helix-turn-helix, score 1.8e-06 216592006799 Predicted helix-turn-helix motif with score 1531.000, SD 4.40 at aa 12-33, sequence ITQLQFGKLTGLSQVHVSRVLG 216592006800 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 216592006801 HMMPfam hit to PF06254, Protein of unknown function (DUF1019), score 3.5e-73 216592006802 Pyocin large subunit [General function prediction only]; Region: COG5529 216592006803 primosomal protein DnaI; Provisional; Region: PRK02854 216592006804 Predicted helix-turn-helix motif with score 1174.000, SD 3.19 at aa 38-59, sequence VTTEDLASALDVTEEVIDSILQ 216592006805 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 216592006806 Predicted helix-turn-helix motif with score 1082.000, SD 2.87 at aa 103-124, sequence KTCEELAGKFGVSTRKVASTLA 216592006807 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 216592006808 HMMPfam hit to PF06163, Bacterial protein of unknown function (DUF97, score 5.9e-70 216592006809 Predicted helix-turn-helix motif with score 1666.000, SD 4.86 at aa 32-53, sequence ETFRQLADKTGVSKTAIRRLSG 216592006810 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 216592006811 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 216592006812 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 216592006813 1 probable transmembrane helix predicted for EC042_1332 by TMHMM2.0 at aa 19-41 216592006814 Hok/gef family; Region: HOK_GEF; pfam01848 216592006815 HMMPfam hit to PF01848, Hok/gef family, score 3.6e-27 216592006816 1 probable transmembrane helix predicted for EC042_1336 by TMHMM2.0 at aa 25-44 216592006817 PS00556 Hok/gef family cell toxic proteins signature. 216592006818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216592006819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592006820 non-specific DNA binding site [nucleotide binding]; other site 216592006821 salt bridge; other site 216592006822 sequence-specific DNA binding site [nucleotide binding]; other site 216592006823 Domain of unknown function (DUF955); Region: DUF955; cl01076 216592006824 HMMPfam hit to PF01381, Helix-turn-helix, score 8.7e-07 216592006825 Predicted helix-turn-helix motif with score 1734.000, SD 5.09 at aa 26-47, sequence LSCEELAEKIGKTKQFVSKLEK 216592006826 HMMPfam hit to PF06114, Domain of unknown function (DUF955), score 3.8e-10 216592006827 Protein of unknown function (DUF968); Region: DUF968; pfam06147 216592006828 HMMPfam hit to PF06914, Protein of unknown function (DUF1277), score 5.8e-201 216592006829 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 216592006830 HMMPfam hit to PF05866, Endodeoxyribonuclease RusA, score 3.3e-47 216592006831 Antitermination protein; Region: Antiterm; pfam03589 216592006832 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216592006833 HMMPfam hit to PF03589, Antitermination protein, score 7.3e-16 216592006834 HMMPfam hit to PF03589, Antitermination protein, score 1.5e-08 216592006835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592006836 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216592006837 DNA methylase; Region: N6_N4_Mtase; pfam01555 216592006838 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216592006839 PS00092 N-6 Adenine-specific DNA methylases signature. 216592006840 HMMPfam hit to PF01555, DNA methylase, score 2.3e-26 216592006841 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 216592006842 Domain of unknown function (DUF303); Region: DUF303; pfam03629 216592006843 HMMPfam hit to PF03629, Domain of unknown function (DUF303), score 3.3e-48 216592006844 Lysis protein S; Region: Lysis_S; pfam04971 216592006845 HMMPfam hit to PF04971, Lysis protein S, score 3.1e-52 216592006846 2 probable transmembrane helices predicted for EC042_1348 by TMHMM2.0 at aa 33-52 and 62-84 216592006848 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 216592006849 catalytic residues [active] 216592006850 Signal peptide predicted for EC042_1349 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.637 between residues 23 and 24 216592006851 1 probable transmembrane helix predicted for EC042_1349 by TMHMM2.0 at aa 7-26 216592006852 HMMPfam hit to PF00959, Phage lysozyme, score 1.2e-33 216592006853 1 probable transmembrane helix predicted for EC042_1350 by TMHMM2.0 at aa 35-52 216592006854 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216592006855 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 4.2e-98 216592006856 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 216592006857 HMMPfam hit to PF07166, Protein of unknown function (DUF1398), score 1.3e-80 216592006858 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 216592006859 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 216592006860 HMMPfam hit to PF07471, Phage DNA packaging protein Nu1, score 3.5e-113 216592006861 Predicted helix-turn-helix motif with score 1804.000, SD 5.33 at aa 3-24, sequence VNKKRLAEIFNVDPRTIERWQS 216592006862 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 216592006863 1 probable transmembrane helix predicted for EC042_1357 by TMHMM2.0 at aa 21-43 216592006864 HMMPfam hit to PF05876, Phage terminase large subunit (GpA), score 0 216592006865 gpW; Region: gpW; pfam02831 216592006866 HMMPfam hit to PF02831, gpW, score 6e-51 216592006867 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 216592006868 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 216592006869 HMMPfam hit to PF05136, Phage portal protein, lambda family, score 3e-245 216592006870 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 216592006871 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 216592006872 tandem repeat interface [polypeptide binding]; other site 216592006873 oligomer interface [polypeptide binding]; other site 216592006874 active site residues [active] 216592006875 1 probable transmembrane helix predicted for EC042_1360 by TMHMM2.0 at aa 71-93 216592006876 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592006877 HMMPfam hit to PF01343, Peptidase family S49, score 1.6e-62 216592006878 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 216592006879 HMMPfam hit to PF02924, Bacteriophage lambda head decoration protein, score 4.1e-68 216592006880 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 216592006881 HMMPfam hit to PF03864, Phage major capsid protein E, score 0 216592006882 DNA packaging protein FI; Region: Packaging_FI; pfam14000 216592006883 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 216592006884 HMMPfam hit to PF05354, Phage Head-Tail Attachment, score 2.1e-71 216592006885 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 216592006886 HMMPfam hit to PF06763, Prophage minor tail protein Z (GPZ), score 6.8e-106 216592006887 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 216592006888 HMMPfam hit to PF06141, Phage minor tail protein U, score 1.9e-101 216592006889 1 probable transmembrane helix predicted for EC042_1366 by TMHMM2.0 at aa 85-107 216592006890 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 216592006891 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 216592006892 HMMPfam hit to PF02368, Bacterial Ig-like domain (group 2), score 5.1e-16 216592006893 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006894 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 216592006895 HMMPfam hit to PF06894, Bacteriophage lambda minor tail prote, score 4.9e-97 216592006896 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 216592006897 HMMPfam hit to PF06223, Minor tail protein T, score 1.1e-29 216592006898 Phage-related minor tail protein [Function unknown]; Region: COG5281 216592006899 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 216592006900 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 216592006901 HMMPfam hit to PF06791, Prophage tail length tape measure protein, score 6.7e-102 216592006902 Phage-related protein [Function unknown]; Region: COG4718 216592006903 HMMPfam hit to PF05939, Phage minor tail protein, score 2.9e-66 216592006904 Phage-related protein [Function unknown]; Region: gp18; COG4672 216592006905 HMMPfam hit to PF05100, Phage minor tail protein L, score 1.2e-149 216592006906 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 216592006907 MPN+ (JAMM) motif; other site 216592006908 Zinc-binding site [ion binding]; other site 216592006909 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592006910 NlpC/P60 family; Region: NLPC_P60; cl17555 216592006911 HMMPfam hit to PF00877, NlpC/P60 family, score 7e-23 216592006912 Phage-related protein, tail component [Function unknown]; Region: COG4723 216592006913 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly prot, score 1.7e-110 216592006914 2 probable transmembrane helices predicted for EC042_1374 by TMHMM2.0 at aa 99-118 and 123-145 216592006915 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592006916 Phage-related protein, tail component [Function unknown]; Region: COG4733 216592006917 Putative phage tail protein; Region: Phage-tail_3; pfam13550 216592006918 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 216592006919 Fibronectin type III protein; Region: DUF3672; pfam12421 216592006920 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0033 216592006921 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 216592006922 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 9.6e-157 216592006923 Signal peptide predicted for EC042_1377 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.718 between residues 24 and 25 216592006924 PS00694 Enterobacterial virulence outer membrane protein signature 1. 216592006925 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216592006926 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 216592006927 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 216592006928 Phage Tail Collar Domain; Region: Collar; pfam07484 216592006929 HMMPfam hit to PF03406, Phage tail fibre repeat, score 1.8e-13 216592006930 HMMPfam hit to PF07484, Phage Tail Collar Domain, score 3e-20 216592006931 HMMPfam hit to PF03335, Phage tail fibre repeat, score 1.1 216592006932 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.024 216592006933 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.97 216592006934 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.11 216592006935 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.65 216592006936 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.6 216592006937 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 216592006938 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 216592006939 HMMPfam hit to PF02413, Caudovirales tail fibre assembly protein, score 8.4e-69 216592006940 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216592006941 Methyltransferase domain; Region: Methyltransf_12; pfam08242 216592006942 S-adenosylmethionine binding site [chemical binding]; other site 216592006943 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 216592006944 HMMPfam hit to PF02413, Caudovirales tail fibre assembly protein, score 3.5e-06 216592006945 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 216592006946 1 probable transmembrane helix predicted for EC042_1382 by TMHMM2.0 at aa 13-35 216592006947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 216592006948 HMMPfam hit to PF05974, Protein of unknown function (DUF892), score 9e-73 216592006949 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 216592006950 dimerization interface [polypeptide binding]; other site 216592006951 metal binding site [ion binding]; metal-binding site 216592006952 HMMPfam hit to PF05974, Protein of unknown function (DUF892), score 2e-89 216592006953 General stress protein [General function prediction only]; Region: GsiB; COG3729 216592006954 PS00017 ATP/GTP-binding site motif A (P-loop). 216592006955 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 216592006956 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 216592006957 substrate binding site [chemical binding]; other site 216592006958 active site 216592006959 catalytic residues [active] 216592006960 heterodimer interface [polypeptide binding]; other site 216592006961 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 1.6e-155 216592006962 PS00167 Tryptophan synthase alpha chain signature. 216592006963 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 216592006964 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 216592006965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592006966 catalytic residue [active] 216592006967 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.4e-117 216592006968 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 216592006969 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 216592006970 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 216592006971 active site 216592006972 ribulose/triose binding site [chemical binding]; other site 216592006973 phosphate binding site [ion binding]; other site 216592006974 substrate (anthranilate) binding pocket [chemical binding]; other site 216592006975 product (indole) binding pocket [chemical binding]; other site 216592006976 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 216592006977 active site 216592006978 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate (PRA) isome, score 3.6e-86 216592006979 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 4.1e-157 216592006980 PS00614 Indole-3-glycerol phosphate synthase signature. 216592006981 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 216592006982 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216592006983 glutamine binding [chemical binding]; other site 216592006984 catalytic triad [active] 216592006985 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216592006986 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216592006987 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 9e-146 216592006988 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 7.7e-26 216592006989 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 6.3e-69 216592006990 PS00442 Glutamine amidotransferases class-I active site. 216592006991 anthranilate synthase component I; Provisional; Region: PRK13564 216592006992 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216592006993 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216592006994 HMMPfam hit to PF00425, chorismate binding enzyme, score 3e-158 216592006995 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 5e-33 216592006996 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 216592006997 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 216592006998 active site 216592006999 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 216592007000 HMMPfam hit to PF02231, PHP domain N-terminal region, score 5.2e-22 216592007001 HMMPfam hit to PF02811, PHP domain C-terminal region, score 5.3e-20 216592007002 hypothetical protein; Provisional; Region: PRK11630 216592007003 HMMPfam hit to PF01300, yrdC domain, score 8.4e-83 216592007004 PS01147 SUA5/yciO/yrdC family signature. 216592007005 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 216592007006 Signal peptide predicted for EC042_1393 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 23 and 24 216592007007 5 probable transmembrane helices predicted for EC042_1393 by TMHMM2.0 at aa 249-266, 398-420, 425-447, 460-482 and 492-514 216592007008 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 216592007009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592007010 RNA binding surface [nucleotide binding]; other site 216592007011 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 216592007012 probable active site [active] 216592007013 HMMPfam hit to PF01479, S4 domain, score 1.2e-08 216592007014 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 5.7e-13 216592007015 PS01149 Rsu family of pseudouridine synthase signature. 216592007016 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 216592007017 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 216592007018 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 216592007019 homodimer interface [polypeptide binding]; other site 216592007020 Walker A motif; other site 216592007021 ATP binding site [chemical binding]; other site 216592007022 hydroxycobalamin binding site [chemical binding]; other site 216592007023 Walker B motif; other site 216592007024 HMMPfam hit to PF02572, ATP:corrinoid adenosyltransferase BtuR, score 2.6e-138 216592007025 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 216592007026 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 216592007027 NADP binding site [chemical binding]; other site 216592007028 homodimer interface [polypeptide binding]; other site 216592007029 active site 216592007030 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.7e-76 216592007031 PS00061 Short-chain dehydrogenases/reductases family signature. 216592007032 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 216592007033 putative inner membrane peptidase; Provisional; Region: PRK11778 216592007034 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216592007035 tandem repeat interface [polypeptide binding]; other site 216592007036 oligomer interface [polypeptide binding]; other site 216592007037 active site residues [active] 216592007038 2 probable transmembrane helices predicted for EC042_1397 by TMHMM2.0 at aa 10-32 and 190-207 216592007039 HMMPfam hit to PF01343, Peptidase family S49, score 6.4e-70 216592007040 hypothetical protein; Provisional; Region: PRK11037 216592007041 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 216592007042 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 216592007043 active site 216592007044 interdomain interaction site; other site 216592007045 putative metal-binding site [ion binding]; other site 216592007046 nucleotide binding site [chemical binding]; other site 216592007047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 216592007048 domain I; other site 216592007049 DNA binding groove [nucleotide binding] 216592007050 phosphate binding site [ion binding]; other site 216592007051 domain II; other site 216592007052 domain III; other site 216592007053 nucleotide binding site [chemical binding]; other site 216592007054 catalytic site [active] 216592007055 domain IV; other site 216592007056 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216592007057 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216592007058 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 216592007059 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 216592007060 HMMPfam hit to PF01751, Toprim domain, score 9.5e-40 216592007061 HMMPfam hit to PF01131, DNA topoisomerase, score 5.1e-202 216592007062 PS00396 Prokaryotic DNA topoisomerase I active site. 216592007063 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 1e-13 216592007064 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 5.9e-15 216592007065 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 216592007066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592007067 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 216592007068 substrate binding site [chemical binding]; other site 216592007069 putative dimerization interface [polypeptide binding]; other site 216592007070 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.5e-15 216592007071 PS00044 Bacterial regulatory proteins, lysR family signature. 216592007072 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216592007073 HMMPfam hit to PF03466, LysR substrate binding domain, score 6e-47 216592007074 aconitate hydratase; Validated; Region: PRK09277 216592007075 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 216592007076 substrate binding site [chemical binding]; other site 216592007077 ligand binding site [chemical binding]; other site 216592007078 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 216592007079 substrate binding site [chemical binding]; other site 216592007080 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 0 216592007081 PS00450 Aconitase family signature 1. 216592007082 PS01244 Aconitase family signature 2. 216592007083 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 1.3e-67 216592007084 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 216592007085 dimerization interface [polypeptide binding]; other site 216592007086 active site 216592007087 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 3.7e-119 216592007088 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216592007089 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 216592007090 active site 216592007091 Signal peptide predicted for EC042_1403 by SignalP 2.0 HMM (Signal peptide probability 0.872) with cleavage site probability 0.487 between residues 22 and 23 216592007092 6 probable transmembrane helices predicted for EC042_1403 by TMHMM2.0 at aa 7-29, 49-68, 75-92, 157-179, 186-208 and 212-229 216592007093 HMMPfam hit to PF01569, PAP2 superfamily, score 3.1e-22 216592007094 Predicted helix-turn-helix motif with score 1069.000, SD 2.83 at aa 132-153, sequence LVKEQLAEENNIPQYLRSHWQK 216592007095 Predicted membrane protein [Function unknown]; Region: COG3771 216592007096 HMMPfam hit to PF06305, Protein of unknown function (DUF1049), score 2.6e-59 216592007097 Signal peptide predicted for EC042_1404 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.608 between residues 22 and 23 216592007098 2 probable transmembrane helices predicted for EC042_1404 by TMHMM2.0 at aa 5-23 and 43-65 216592007099 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 216592007100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216592007101 TPR motif; other site 216592007102 binding surface 216592007103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592007104 binding surface 216592007105 TPR motif; other site 216592007106 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.25 216592007107 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0026 216592007108 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 216592007109 active site 216592007110 dimer interface [polypeptide binding]; other site 216592007111 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 6.3e-92 216592007112 PS00156 Orotidine 5'-phosphate decarboxylase active site. 216592007113 translation initiation factor Sui1; Validated; Region: PRK06824 216592007114 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 216592007115 putative rRNA binding site [nucleotide binding]; other site 216592007116 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 6.9e-34 216592007117 PS01118 Translation initiation factor SUI1 signature. 216592007118 lipoprotein; Provisional; Region: PRK10540 216592007119 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 8-29, sequence MTAAVLAITLAMSLSACSNWSK 216592007120 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592007121 Signal peptide predicted for EC042_1408 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.563 between residues 23 and 24 216592007122 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216592007123 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216592007124 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592007125 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.9e-52 216592007126 Predicted helix-turn-helix motif with score 1806.000, SD 5.34 at aa 18-39, sequence VSVTDLAKATGVSEVTIRQDLN 216592007127 hypothetical protein; Provisional; Region: PRK13658 216592007128 RNase II stability modulator; Provisional; Region: PRK10060 216592007129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592007130 putative active site [active] 216592007131 heme pocket [chemical binding]; other site 216592007132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592007133 metal binding site [ion binding]; metal-binding site 216592007134 active site 216592007135 I-site; other site 216592007136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592007137 HMMPfam hit to PF00563, EAL domain, score 1e-118 216592007138 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-66 216592007139 exoribonuclease II; Provisional; Region: PRK05054 216592007140 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 216592007141 RNB domain; Region: RNB; pfam00773 216592007142 S1 RNA binding domain; Region: S1; pfam00575 216592007143 HMMPfam hit to PF00575, S1 RNA binding domain, score 3e-09 216592007144 PS01175 Ribonuclease II family signature. 216592007145 HMMPfam hit to PF00773, RNB-like protein, score 5.1e-131 216592007146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 216592007147 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216592007148 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 216592007149 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 216592007150 NAD binding site [chemical binding]; other site 216592007151 homotetramer interface [polypeptide binding]; other site 216592007152 homodimer interface [polypeptide binding]; other site 216592007153 substrate binding site [chemical binding]; other site 216592007154 active site 216592007155 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.3e-15 216592007156 1 probable transmembrane helix predicted for EC042_1415 by TMHMM2.0 at aa 21-43 216592007157 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 216592007158 putative active site [active] 216592007159 HMMPfam hit to PF04480, Protein of unknown function (DUF559), score 4.8e-76 216592007160 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 216592007161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592007162 Walker A/P-loop; other site 216592007163 ATP binding site [chemical binding]; other site 216592007164 Q-loop/lid; other site 216592007165 ABC transporter signature motif; other site 216592007166 Walker B; other site 216592007167 D-loop; other site 216592007168 H-loop/switch region; other site 216592007169 HMMPfam hit to PF00005, ABC transporter, score 1.6e-67 216592007170 PS00211 ABC transporters family signature. 216592007171 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007172 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 216592007173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592007174 Walker A/P-loop; other site 216592007175 ATP binding site [chemical binding]; other site 216592007176 Q-loop/lid; other site 216592007177 ABC transporter signature motif; other site 216592007178 Walker B; other site 216592007179 D-loop; other site 216592007180 H-loop/switch region; other site 216592007181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592007182 HMMPfam hit to PF00005, ABC transporter, score 3.1e-61 216592007183 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007184 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 216592007185 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216592007186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592007187 dimer interface [polypeptide binding]; other site 216592007188 conserved gate region; other site 216592007189 putative PBP binding loops; other site 216592007190 ABC-ATPase subunit interface; other site 216592007191 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.8e-27 216592007192 5 probable transmembrane helices predicted for EC042_1419 by TMHMM2.0 at aa 30-52, 100-122, 137-170, 201-223 and 261-283 216592007193 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 216592007194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592007195 dimer interface [polypeptide binding]; other site 216592007196 conserved gate region; other site 216592007197 putative PBP binding loops; other site 216592007198 ABC-ATPase subunit interface; other site 216592007199 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.5e-52 216592007200 5 probable transmembrane helices predicted for EC042_1420 by TMHMM2.0 at aa 9-31, 80-102, 109-131, 251-273 and 286-308 216592007201 Signal peptide predicted for EC042_1420 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.548 between residues 37 and 38 216592007202 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216592007203 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216592007204 peptide binding site [polypeptide binding]; other site 216592007205 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.9e-72 216592007206 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592007207 Signal peptide predicted for EC042_1421 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592007208 Signal peptide predicted for EC042_1422 by SignalP 2.0 HMM (Signal peptide probability 0.690) with cleavage site probability 0.279 between residues 28 and 29 216592007209 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592007210 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 216592007211 Present in 0157. Absent in the 3 UPEC strains, APEC and EPEC. Carries putrescine? utilization genes 216592007212 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216592007213 HMMPfam hit to PF00324, Amino acid permease, score 2.3e-23 216592007214 12 probable transmembrane helices predicted for EC042_1424 by TMHMM2.0 at aa 39-58, 73-95, 116-138, 153-175, 180-200, 220-239, 260-282, 308-330, 359-378, 382-404, 417-436 and 441-460 216592007215 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216592007216 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216592007217 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 5.3e-104 216592007218 PS00181 Glutamine synthetase putative ATP-binding region signature. 216592007219 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 216592007220 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 216592007221 catalytic triad [active] 216592007222 HMMPfam hit to PF07722, Peptidase C26, score 6.3e-112 216592007223 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 0.00046 216592007224 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 216592007225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592007226 non-specific DNA binding site [nucleotide binding]; other site 216592007227 salt bridge; other site 216592007228 sequence-specific DNA binding site [nucleotide binding]; other site 216592007229 Cupin domain; Region: Cupin_2; pfam07883 216592007230 HMMPfam hit to PF01381, Helix-turn-helix, score 1.9e-15 216592007231 Predicted helix-turn-helix motif with score 1738.000, SD 5.11 at aa 21-42, sequence LSQRRAAELSGLTHSAISTIEQ 216592007232 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 216592007233 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 216592007234 NAD(P) binding site [chemical binding]; other site 216592007235 catalytic residues [active] 216592007236 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5.1e-257 216592007237 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007238 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592007239 PS00070 Aldehyde dehydrogenases cysteine active site. 216592007240 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216592007241 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216592007242 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.6e-105 216592007243 4-aminobutyrate transaminase; Provisional; Region: PRK09792 216592007244 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592007245 inhibitor-cofactor binding pocket; inhibition site 216592007246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592007247 catalytic residue [active] 216592007248 Signal peptide predicted for EC042_1430 by SignalP 2.0 HMM (Signal peptide probability 0.659) with cleavage site probability 0.445 between residues 28 and 29 216592007249 HMMPfam hit to PF00202, Aminotransferase class-III, score 7.7e-162 216592007250 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592007251 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 216592007252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592007253 Walker A motif; other site 216592007254 ATP binding site [chemical binding]; other site 216592007255 Walker B motif; other site 216592007256 arginine finger; other site 216592007257 Predicted helix-turn-helix motif with score 1395.000, SD 3.94 at aa 300-321, sequence YNQKRAAELLGLTYHQFRALLK 216592007258 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592007259 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.4e-125 216592007260 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592007261 phage shock protein PspA; Provisional; Region: PRK10698 216592007262 HMMPfam hit to PF04012, PspA/IM30 family, score 8.2e-54 216592007263 phage shock protein B; Provisional; Region: pspB; PRK09458 216592007264 HMMPfam hit to PF06667, Phage shock protein B, score 1.4e-50 216592007265 1 probable transmembrane helix predicted for EC042_1433 by TMHMM2.0 at aa 4-26 216592007266 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 216592007267 phage shock protein C; Region: phageshock_pspC; TIGR02978 216592007268 HMMPfam hit to PF04024, PspC domain, score 2.2e-30 216592007269 1 probable transmembrane helix predicted for EC042_1434 by TMHMM2.0 at aa 39-61 216592007270 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 216592007271 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216592007272 active site residue [active] 216592007273 Signal peptide predicted for EC042_1436 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 216592007274 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.4e-14 216592007275 Predicted ATPase [General function prediction only]; Region: COG3106 216592007276 HMMPfam hit to PF04317, YcjX-like family, DUF463, score 0 216592007277 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007278 hypothetical protein; Provisional; Region: PRK05415 216592007279 TIGR01620 family protein; Region: hyp_HI0043 216592007280 HMMPfam hit to PF05128, Family of unknown function (DUF697), score 1.6e-214 216592007281 3 probable transmembrane helices predicted for EC042_1438 by TMHMM2.0 at aa 70-89, 99-121 and 211-233 216592007282 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 216592007283 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 216592007284 putative aromatic amino acid binding site; other site 216592007285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592007286 Walker A motif; other site 216592007287 ATP binding site [chemical binding]; other site 216592007288 Walker B motif; other site 216592007289 arginine finger; other site 216592007290 HMMPfam hit to PF01842, ACT domain, score 1.2e-06 216592007291 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 9e-114 216592007292 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592007293 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592007294 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592007295 Predicted helix-turn-helix motif with score 1684.000, SD 4.92 at aa 490-511, sequence PSTRKLAKRLGVSHTAIANKLR 216592007296 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 216592007297 dimer interface [polypeptide binding]; other site 216592007298 catalytic triad [active] 216592007299 peroxidatic and resolving cysteines [active] 216592007300 HMMPfam hit to PF00578, AhpC/TSA family, score 7.5e-47 216592007301 PS01265 Tpx family signature. 216592007302 PS00012 Phosphopantetheine attachment site. 216592007303 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 216592007304 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 216592007305 active site 216592007306 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 3.4e-48 216592007307 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216592007308 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 1e-82 216592007309 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 216592007310 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 216592007311 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 216592007312 putative active site [active] 216592007313 Zn binding site [ion binding]; other site 216592007314 HMMPfam hit to PF00246, Zinc carboxypeptidase, score 9.1e-28 216592007315 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 216592007316 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216592007317 putative NAD(P) binding site [chemical binding]; other site 216592007318 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216592007319 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216592007320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592007321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592007322 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216592007323 putative effector binding pocket; other site 216592007324 putative dimerization interface [polypeptide binding]; other site 216592007325 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-21 216592007326 Predicted helix-turn-helix motif with score 1548.000, SD 4.46 at aa 19-40, sequence RSFTRAAARLSMAQSALSQIVR 216592007327 PS00044 Bacterial regulatory proteins, lysR family signature. 216592007328 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.7e-44 216592007329 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 216592007330 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 216592007331 peptide binding site [polypeptide binding]; other site 216592007332 Signal peptide predicted for EC042_1446 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.952 between residues 22 and 23 216592007333 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.3e-83 216592007334 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592007335 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216592007336 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592007337 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.4e-77 216592007338 PS01246 Uncharacterized protein family UPF0003 signature. 216592007339 4 probable transmembrane helices predicted for EC042_1447 by TMHMM2.0 at aa 10-32, 39-61, 76-98 and 126-148 216592007340 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 216592007341 Signal peptide predicted for EC042_1448 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.574 between residues 31 and 32 216592007342 2 probable transmembrane helices predicted for EC042_1448 by TMHMM2.0 at aa 13-35 and 60-82 216592007343 Transposase IS200 like; Region: Y1_Tnp; pfam01797 216592007344 HMMPfam hit to PF01797, Transposase IS200 like, score 1.5e-66 216592007345 universal stress protein UspE; Provisional; Region: PRK11175 216592007346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592007347 Ligand Binding Site [chemical binding]; other site 216592007348 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592007349 Ligand Binding Site [chemical binding]; other site 216592007350 HMMPfam hit to PF00582, Universal stress protein family, score 5.3e-11 216592007351 HMMPfam hit to PF00582, Universal stress protein family, score 1.5e-16 216592007352 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 216592007353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216592007354 ligand binding site [chemical binding]; other site 216592007355 flexible hinge region; other site 216592007356 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216592007357 putative switch regulator; other site 216592007358 non-specific DNA interactions [nucleotide binding]; other site 216592007359 DNA binding site [nucleotide binding] 216592007360 sequence specific DNA binding site [nucleotide binding]; other site 216592007361 putative cAMP binding site [chemical binding]; other site 216592007362 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 3.3e-15 216592007363 PS00042 Bacterial regulatory proteins, crp family signature. 216592007364 Predicted helix-turn-helix motif with score 1841.000, SD 5.46 at aa 214-235, sequence MTRGDIGNYLGLTVETISRLLG 216592007365 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 4.1e-20 216592007366 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 216592007367 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 216592007368 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216592007369 DNA binding site [nucleotide binding] 216592007370 active site 216592007371 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 3.3e-59 216592007372 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 216592007373 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 1.9e-26 216592007374 Present in 0157, absent in Uropathogenic, aminobenzoyl-glutamate utilization proteins (regulator, transporter, 2 utilization proteins) 216592007375 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 216592007376 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 216592007377 HMMPfam hit to PF03806, AbgT putative transporter family, score 0 216592007378 13 probable transmembrane helices predicted for EC042_1453 by TMHMM2.0 at aa 30-52, 87-109, 121-139, 143-160, 165-187, 214-231, 259-281, 301-323, 344-366, 381-403, 408-430, 440-458 and 470-492 216592007379 Signal peptide predicted for EC042_1453 by SignalP 2.0 HMM (Signal peptide probability 0.637) with cleavage site probability 0.614 between residues 54 and 55 216592007380 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 216592007381 amidohydrolase; Region: amidohydrolases; TIGR01891 216592007382 putative metal binding site [ion binding]; other site 216592007383 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.0067 216592007384 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 216592007385 amidohydrolase; Region: amidohydrolases; TIGR01891 216592007386 putative metal binding site [ion binding]; other site 216592007387 dimer interface [polypeptide binding]; other site 216592007388 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.7e-36 216592007389 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 0.002 216592007390 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 216592007391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592007392 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 216592007393 putative substrate binding pocket [chemical binding]; other site 216592007394 putative dimerization interface [polypeptide binding]; other site 216592007395 PS00041 Bacterial regulatory proteins, araC family signature. 216592007396 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.9e-19 216592007397 Predicted helix-turn-helix motif with score 1521.000, SD 4.37 at aa 20-41, sequence GSIRGASRMLNMSQPALSKSIQ 216592007398 PS00044 Bacterial regulatory proteins, lysR family signature. 216592007399 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-42 216592007400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 216592007401 Smr domain; Region: Smr; pfam01713 216592007402 HMMPfam hit to PF01713, Smr domain, score 3.7e-30 216592007403 PAS domain S-box; Region: sensory_box; TIGR00229 216592007404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592007405 putative active site [active] 216592007406 heme pocket [chemical binding]; other site 216592007407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592007408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592007409 metal binding site [ion binding]; metal-binding site 216592007410 active site 216592007411 I-site; other site 216592007412 HMMPfam hit to PF00990, GGDEF domain, score 3.7e-67 216592007413 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216592007414 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 216592007415 Cl binding site [ion binding]; other site 216592007416 oligomer interface [polypeptide binding]; other site 216592007417 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 0.0003 216592007418 2 probable transmembrane helices predicted for EC042_1459 by TMHMM2.0 at aa 272-294 and 299-321 216592007419 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 216592007420 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216592007421 ATP binding site [chemical binding]; other site 216592007422 Mg++ binding site [ion binding]; other site 216592007423 motif III; other site 216592007424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592007425 nucleotide binding region [chemical binding]; other site 216592007426 ATP-binding site [chemical binding]; other site 216592007427 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 216592007428 putative RNA binding site [nucleotide binding]; other site 216592007429 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.4e-67 216592007430 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007431 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592007432 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.3e-30 216592007433 HMMPfam hit to PF03880, DbpA RNA binding domain, score 1e-36 216592007434 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007435 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 216592007436 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 216592007437 Ligand Binding Site [chemical binding]; other site 216592007438 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 216592007439 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216592007440 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 216592007441 Int/Topo IB signature motif; other site 216592007442 HMMPfam hit to PF00589, Phage integrase family, score 3.4e-14 216592007443 prophage 3. Absent in Uropathogenic, divergent in 0157, prophage, carrying iron transport proteins (x4) 216592007444 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 216592007445 HMMPfam hit to PF06806, Putative excisionase (DUF1233), score 0.00033 216592007446 hypothetical protein; Provisional; Region: PRK09750 216592007447 HMMPfam hit to PF06688, Protein of unknown function (DUF1187), score 1.5e-45 216592007448 RecT family; Region: RecT; pfam03837 216592007449 HMMPfam hit to PF03837, RecT family, score 3.6e-41 216592007450 exonuclease VIII; Reviewed; Region: PRK09709 216592007451 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 216592007452 HMMPfam hit to PF06630, Enterobacterial exodeoxyribonuclease VIII, score 2.6e-132 216592007453 hypothetical protein; Reviewed; Region: PRK09790 216592007454 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 216592007455 Superinfection exclusion protein B; Region: SieB; pfam14163 216592007456 2 probable transmembrane helices predicted for EC042_1471 by TMHMM2.0 at aa 61-83 and 87-109 216592007457 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 216592007458 HMMPfam hit to PF07151, Protein of unknown function (DUF1391), score 1.8e-32 216592007459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592007460 sequence-specific DNA binding site [nucleotide binding]; other site 216592007461 transcriptional repressor DicA; Reviewed; Region: PRK09706 216592007462 salt bridge; other site 216592007463 Helix-turn-helix domain; Region: HTH_17; cl17695 216592007464 Predicted helix-turn-helix motif with score 1509.000, SD 4.33 at aa 13-34, sequence VRVSVVADVCGVSQRAIYKWMD 216592007465 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 216592007466 HMMPfam hit to PF06254, Protein of unknown function (DUF1019), score 4.3e-69 216592007467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 216592007468 primosomal protein DnaI; Provisional; Region: PRK02854 216592007469 HMMPfam hit to PF07120, Protein of unknown function (DUF1376), score 2.5e-56 216592007470 putative replication protein; Provisional; Region: PRK12377 216592007471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592007472 Walker A motif; other site 216592007473 ATP binding site [chemical binding]; other site 216592007474 Walker B motif; other site 216592007475 arginine finger; other site 216592007476 HMMPfam hit to PF01695, IstB-like ATP binding protein, score 2.1e-07 216592007477 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 216592007478 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 216592007479 HMMPfam hit to PF06163, Bacterial protein of unknown function (DUF97, score 1.7e-97 216592007480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 216592007481 HMMPfam hit to PF02677, Uncharacterized BCR, COG1636, score 5.5e-126 216592007482 Hok/gef family; Region: HOK_GEF; pfam01848 216592007483 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 216592007484 HMMPfam hit to PF07105, Protein of unknown function (DUF1367), score 5.1e-160 216592007485 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 216592007486 HMMPfam hit to PF07102, Protein of unknown function (DUF1364), score 1.2e-78 216592007487 PS00190 Cytochrome c family heme-binding site signature. 216592007488 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 216592007489 HMMPfam hit to PF06576, Protein of unknown function (DUF1133), score 2.4e-128 216592007490 Lysis protein S; Region: Lysis_S; pfam04971 216592007491 HMMPfam hit to PF04971, Lysis protein S, score 4.9e-52 216592007492 2 probable transmembrane helices predicted for EC042_1486 by TMHMM2.0 at aa 36-55 and 65-87 216592007493 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 216592007494 catalytic residues [active] 216592007495 Signal peptide predicted for EC042_1487 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.390 between residues 31 and 32 216592007496 HMMPfam hit to PF00959, Phage lysozyme, score 6.8e-46 216592007497 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216592007498 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 4.1e-107 216592007499 Signal peptide predicted for EC042_1488 by SignalP 2.0 HMM (Signal peptide probability 0.909) with cleavage site probability 0.870 between residues 22 and 23 216592007500 1 probable transmembrane helix predicted for EC042_1488 by TMHMM2.0 at aa 4-26 216592007501 Cation transport protein; Region: TrkH; cl17365 216592007502 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 216592007503 11 probable transmembrane helices predicted for EC042_1489 by TMHMM2.0 at aa 12-34, 39-58, 71-93, 139-161, 188-207, 241-263, 276-298, 334-356, 398-420, 430-452 and 459-481 216592007504 HMMPfam hit to PF02386, Cation transport protein, score 3.5e-113 216592007505 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216592007506 ParB-like nuclease domain; Region: ParBc; pfam02195 216592007507 HMMPfam hit to PF02195, ParB-like nuclease domain, score 4.7e-23 216592007508 Terminase small subunit; Region: Terminase_2; cl01513 216592007509 Phage terminase large subunit; Region: Terminase_3; cl12054 216592007510 Terminase-like family; Region: Terminase_6; pfam03237 216592007511 HMMPfam hit to PF03237, Protein of unknown function DUF264, score 3.2e-23 216592007512 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007513 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 216592007514 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 216592007515 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 216592007516 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 216592007517 PS00215 Mitochondrial energy transfer proteins signature. 216592007518 Phage-related minor tail protein [Function unknown]; Region: COG5281 216592007519 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 216592007520 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 216592007521 HMMPfam hit to PF06791, Prophage tail length tape measure protein, score 2e-78 216592007522 Phage minor tail protein; Region: Phage_min_tail; pfam05939 216592007523 HMMPfam hit to PF05939, Phage minor tail protein, score 1.2e-33 216592007524 Phage-related protein [Function unknown]; Region: gp18; COG4672 216592007525 HMMPfam hit to PF05100, Phage minor tail protein L, score 7.3e-147 216592007526 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 216592007527 MPN+ (JAMM) motif; other site 216592007528 Zinc-binding site [ion binding]; other site 216592007529 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592007530 NlpC/P60 family; Region: NLPC_P60; cl17555 216592007531 HMMPfam hit to PF00877, NlpC/P60 family, score 2.1e-23 216592007532 Phage-related protein, tail component [Function unknown]; Region: COG4723 216592007533 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly prot, score 1.5e-114 216592007534 2 probable transmembrane helices predicted for EC042_1511 by TMHMM2.0 at aa 100-117 and 122-144 216592007535 Phage-related protein, tail component [Function unknown]; Region: COG4733 216592007536 Putative phage tail protein; Region: Phage-tail_3; pfam13550 216592007537 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 216592007538 Fibronectin type III protein; Region: DUF3672; pfam12421 216592007539 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0021 216592007540 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 216592007541 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 2e-161 216592007542 Signal peptide predicted for EC042_1513 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.963 between residues 24 and 25 216592007543 PS00694 Enterobacterial virulence outer membrane protein signature 1. 216592007544 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216592007545 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 216592007546 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 216592007547 2 probable transmembrane helices predicted for EC042_1517 by TMHMM2.0 at aa 12-34 and 76-98 216592007548 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592007549 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216592007550 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592007551 ABC-ATPase subunit interface; other site 216592007552 dimer interface [polypeptide binding]; other site 216592007553 putative PBP binding regions; other site 216592007554 8 probable transmembrane helices predicted for EC042_1518 by TMHMM2.0 at aa 13-35, 55-77, 94-113, 128-150, 170-192, 197-214, 221-243 and 248-270 216592007555 HMMPfam hit to PF00950, ABC 3 transport family, score 5.2e-97 216592007556 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216592007557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592007558 ABC-ATPase subunit interface; other site 216592007559 dimer interface [polypeptide binding]; other site 216592007560 putative PBP binding regions; other site 216592007561 7 probable transmembrane helices predicted for EC042_1519 by TMHMM2.0 at aa 13-35, 50-72, 92-111, 126-148, 178-200, 220-242 and 249-271 216592007562 HMMPfam hit to PF00950, ABC 3 transport family, score 4.3e-110 216592007563 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 216592007564 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216592007565 HMMPfam hit to PF00005, ABC transporter, score 6.3e-48 216592007566 PS00211 ABC transporters family signature. 216592007567 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007568 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 216592007569 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 216592007570 metal binding site [ion binding]; metal-binding site 216592007571 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 1.9e-123 216592007572 Signal peptide predicted for EC042_1521 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.595 between residues 26 and 27 216592007573 1 probable transmembrane helix predicted for EC042_1521 by TMHMM2.0 at aa 7-26 216592007574 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592007575 Ligand Binding Site [chemical binding]; other site 216592007576 HMMPfam hit to PF00582, Universal stress protein family, score 3.2e-19 216592007577 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592007578 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592007579 trimer interface [polypeptide binding]; other site 216592007580 eyelet of channel; other site 216592007581 HMMPfam hit to PF00267, Gram-negative porin, score 8.8e-216 216592007582 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216592007583 Signal peptide predicted for EC042_1523 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592007584 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 216592007585 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 216592007586 dimer interface [polypeptide binding]; other site 216592007587 PYR/PP interface [polypeptide binding]; other site 216592007588 TPP binding site [chemical binding]; other site 216592007589 substrate binding site [chemical binding]; other site 216592007590 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 216592007591 Domain of unknown function; Region: EKR; smart00890 216592007592 4Fe-4S binding domain; Region: Fer4_6; pfam12837 216592007593 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592007594 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 216592007595 TPP-binding site [chemical binding]; other site 216592007596 dimer interface [polypeptide binding]; other site 216592007597 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 1.6e-91 216592007598 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7.2e-05 216592007599 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592007600 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 5.5e-06 216592007601 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592007602 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoredu, score 2.7e-82 216592007603 PS00024 Hemopexin domain signature. 216592007604 HMMPfam hit to PF01855, Pyruvate flavodoxin/ferredoxin oxidoredu, score 1.3e-122 216592007605 metabolite-proton symporter; Region: 2A0106; TIGR00883 216592007606 heat-inducible protein; Provisional; Region: PRK10449 216592007607 HMMPfam hit to PF03724, Domain of unknown function (306), score 1.8e-32 216592007608 Signal peptide predicted for EC042_1526 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.581 between residues 19 and 20 216592007609 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592007610 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 216592007611 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216592007612 putative ligand binding site [chemical binding]; other site 216592007613 putative NAD binding site [chemical binding]; other site 216592007614 catalytic site [active] 216592007615 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 3.2e-92 216592007616 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216592007617 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216592007618 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216592007619 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007620 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 5e-23 216592007621 hypothetical protein; Provisional; Region: PRK10695 216592007622 Signal peptide predicted for EC042_1528 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.622 between residues 34 and 35 216592007623 1 probable transmembrane helix predicted for EC042_1528 by TMHMM2.0 at aa 7-29 216592007624 PS00591 Glycosyl hydrolases family 10 active site. 216592007625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 216592007626 Signal peptide predicted for EC042_1529 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592007627 1 probable transmembrane helix predicted for EC042_1529 by TMHMM2.0 at aa 32-51 216592007628 HMMPfam hit to PF07027, Protein of unknown function (DUF1318), score 4.4e-63 216592007629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592007630 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.9e-10 216592007631 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 216592007632 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 216592007633 putative trimer interface [polypeptide binding]; other site 216592007634 putative metal binding site [ion binding]; other site 216592007635 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.39 216592007636 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 34 216592007637 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.4 216592007638 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1 216592007639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592007640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592007641 active site 216592007642 catalytic tetrad [active] 216592007643 HMMPfam hit to PF00248, Aldo/keto reductase family, score 2.7e-67 216592007644 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 216592007645 Signal peptide predicted for EC042_1533 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.980 between residues 24 and 25 216592007646 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216592007647 Signal peptide predicted for EC042_1534 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.956 between residues 52 and 53 216592007648 5 probable transmembrane helices predicted for EC042_1534 by TMHMM2.0 at aa 44-66, 87-109, 119-141, 154-171 and 176-198 216592007649 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.2e-19 216592007650 PS00237 G-protein coupled receptors signature. 216592007651 This CDS is disrupted by the insertion of an IS element 216592007652 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 216592007653 HMMPfam hit to PF03400, IS1 transposase, score 1e-103 216592007654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592007655 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592007656 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592007657 HMMPfam hit to PF03811, Insertion element protein, score 9.5e-70 216592007658 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592007659 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007660 HMMPfam hit to PF01148, Cytidylyltransferase family, score 1.1e-77 216592007661 7 probable transmembrane helices predicted for EC042_1537 by TMHMM2.0 at aa 10-32, 45-67, 87-109, 116-138, 158-180, 187-206 and 226-243 216592007662 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007663 PS01315 Phosphatidate cytidylyltransferase signature. 216592007664 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216592007665 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216592007666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592007667 S-adenosylmethionine binding site [chemical binding]; other site 216592007668 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 216592007669 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216592007670 active site 216592007671 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 216592007672 active site 216592007673 catalytic residues [active] 216592007674 8 probable transmembrane helices predicted for EC042_1539 by TMHMM2.0 at aa 33-55, 82-104, 116-138, 158-175, 188-205, 209-228, 241-263 and 267-289 216592007675 HMMPfam hit to PF01569, PAP2 superfamily, score 7.7e-19 216592007676 HMMPfam hit to PF00782, Dual specificity phosphatase, catalytic doma, score 3.7e-40 216592007677 PS00383 Tyrosine specific protein phosphatases active site. 216592007678 azoreductase; Reviewed; Region: PRK00170 216592007679 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216592007680 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.8e-61 216592007681 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 216592007682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592007683 ATP binding site [chemical binding]; other site 216592007684 putative Mg++ binding site [ion binding]; other site 216592007685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592007686 nucleotide binding region [chemical binding]; other site 216592007687 ATP-binding site [chemical binding]; other site 216592007688 Helicase associated domain (HA2); Region: HA2; pfam04408 216592007689 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 216592007690 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 216592007691 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4e-08 216592007692 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007693 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 6.8e-12 216592007694 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 6.9e-30 216592007695 HMMPfam hit to PF07717, Domain of unknown function (DUF1605), score 1.4e-24 216592007697 HMMPfam hit to PF02698, DUF218 domain, score 3.9e-21 216592007698 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 216592007699 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216592007700 NAD binding site [chemical binding]; other site 216592007701 catalytic residues [active] 216592007702 substrate binding site [chemical binding]; other site 216592007703 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 2.9e-248 216592007704 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592007705 PS00070 Aldehyde dehydrogenases cysteine active site. 216592007706 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 216592007707 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 216592007708 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216592007709 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 7.6e-96 216592007710 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216592007711 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1.8e-87 216592007712 PS00430 TonB-dependent receptor proteins signature 1. 216592007713 cytochrome b561; Provisional; Region: PRK11513 216592007714 HMMPfam hit to PF01292, Cytochrome b561 family, score 4.4e-76 216592007715 4 probable transmembrane helices predicted for EC042_1548 by TMHMM2.0 at aa 20-42, 52-74, 95-117 and 152-174 216592007716 hypothetical protein; Provisional; Region: PRK10040 216592007717 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 216592007718 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 216592007719 dimer interface [polypeptide binding]; other site 216592007720 ligand binding site [chemical binding]; other site 216592007721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592007722 dimerization interface [polypeptide binding]; other site 216592007723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216592007724 dimer interface [polypeptide binding]; other site 216592007725 putative CheW interface [polypeptide binding]; other site 216592007726 Signal peptide predicted for EC042_1549 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.801 between residues 39 and 40 216592007727 2 probable transmembrane helices predicted for EC042_1549 by TMHMM2.0 at aa 20-42 and 199-221 216592007728 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 7.6e-52 216592007729 HMMPfam hit to PF00672, HAMP domain, score 4.4e-16 216592007730 PS00538 Bacterial chemotaxis sensory transducers signature. 216592007731 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 8.3e-120 216592007732 PS00287 Cysteine proteases inhibitors signature. 216592007733 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 216592007734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592007735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592007736 dimerization interface [polypeptide binding]; other site 216592007737 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.5e-36 216592007738 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-18 216592007739 PS00044 Bacterial regulatory proteins, lysR family signature. 216592007740 Predicted helix-turn-helix motif with score 1622.000, SD 4.71 at aa 49-70, sequence GTLGRAAETLNLSQPALSKTLN 216592007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 216592007742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 216592007743 PS00237 G-protein coupled receptors signature. 216592007744 HMMPfam hit to PF07063, Protein of unknown function (DUF1338), score 1.3e-77 216592007745 PS00294 Prenyl group binding site (CAAX box). 216592007746 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 216592007747 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 216592007748 Signal peptide predicted for EC042_1552 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 32 and 33 216592007749 HMMPfam hit to PF04349, Periplasmic glucan biosynthesis protein, Mdo, score 2.8e-168 216592007750 hypothetical protein; Provisional; Region: PRK11415 216592007751 HMMPfam hit to PF04325, Protein of unknown function (DUF465), score 8.8e-20 216592007752 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216592007753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592007754 Coenzyme A binding pocket [chemical binding]; other site 216592007755 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.7e-14 216592007756 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216592007757 putative trimer interface [polypeptide binding]; other site 216592007758 putative CoA binding site [chemical binding]; other site 216592007759 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 216592007760 putative trimer interface [polypeptide binding]; other site 216592007761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216592007762 putative CoA binding site [chemical binding]; other site 216592007763 putative trimer interface [polypeptide binding]; other site 216592007764 putative CoA binding site [chemical binding]; other site 216592007765 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 12 216592007766 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.1e+02 216592007767 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2.8 216592007768 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 43 216592007769 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 216592007770 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 45 216592007771 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 216592007772 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 216592007773 gating phenylalanine in ion channel; other site 216592007774 8 probable transmembrane helices predicted for EC042_1556 by TMHMM2.0 at aa 43-65, 80-102, 115-137, 193-215, 236-255, 265-283, 290-312 and 322-344 216592007775 HMMPfam hit to PF03595, C4-dicarboxylate transporter/malic aci, score 8.5e-89 216592007776 tellurite resistance protein TehB; Provisional; Region: PRK11207 216592007777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592007778 S-adenosylmethionine binding site [chemical binding]; other site 216592007779 HMMPfam hit to PF03848, Tellurite resistance protein TehB, score 2.6e-160 216592007780 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 216592007781 Signal peptide predicted for EC042_1558 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.679 between residues 24 and 25 216592007782 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592007783 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 216592007784 benzoate transporter; Region: benE; TIGR00843 216592007785 HMMPfam hit to PF03594, Benzoate membrane transport protein, score 2.6e-235 216592007786 11 probable transmembrane helices predicted for EC042_1559 by TMHMM2.0 at aa 98-120, 130-152, 154-176, 181-203, 208-230, 250-272, 293-312, 332-354, 375-397, 402-424 and 437-459 216592007787 PS00041 Bacterial regulatory proteins, araC family signature. 216592007788 Predicted helix-turn-helix motif with score 1018.000, SD 2.65 at aa 132-153, sequence GWMTALGLAMGVSTLTLTLWYR 216592007789 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216592007790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592007791 non-specific DNA binding site [nucleotide binding]; other site 216592007792 salt bridge; other site 216592007793 sequence-specific DNA binding site [nucleotide binding]; other site 216592007794 Cupin domain; Region: Cupin_2; pfam07883 216592007795 HMMPfam hit to PF01381, Helix-turn-helix, score 1.3e-17 216592007796 Predicted helix-turn-helix motif with score 1598.000, SD 4.63 at aa 21-42, sequence WSLSRLAEATGVSKAMLGQIER 216592007797 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216592007798 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 216592007799 Peptidase family U32; Region: Peptidase_U32; pfam01136 216592007800 Collagenase; Region: DUF3656; pfam12392 216592007801 HMMPfam hit to PF01136, Peptidase family U32, score 2.6e-97 216592007802 PS01276 Peptidase family U32 signature. 216592007803 HTH-like domain; Region: HTH_21; pfam13276 216592007804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592007805 Integrase core domain; Region: rve; pfam00665 216592007806 Integrase core domain; Region: rve_2; pfam13333 216592007807 HMMPfam hit to PF00665, Integrase core domain, score 7.6e-45 216592007808 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592007810 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592007811 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592007812 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 20-41, sequence AGIISTAKLFQLSHTSLSHWIN 216592007813 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 216592007814 Signal peptide predicted for EC042_1564 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 22 and 23 216592007815 YcfA-like protein; Region: YcfA; pfam07927 216592007816 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 216592007817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592007818 non-specific DNA binding site [nucleotide binding]; other site 216592007819 salt bridge; other site 216592007820 sequence-specific DNA binding site [nucleotide binding]; other site 216592007821 HMMPfam hit to PF03681, Uncharacterised protein family (UPF0150), score 3.7e-21 216592007822 HMMPfam hit to PF01381, Helix-turn-helix, score 8.7e-07 216592007823 Predicted helix-turn-helix motif with score 1769.000, SD 5.21 at aa 98-119, sequence ITQQELARRIGKPKQEITRLFN 216592007824 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216592007825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592007826 DNA-binding site [nucleotide binding]; DNA binding site 216592007827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592007828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592007829 homodimer interface [polypeptide binding]; other site 216592007830 catalytic residue [active] 216592007831 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 4.5e-15 216592007832 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.5e-12 216592007833 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216592007834 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216592007835 Signal peptide predicted for EC042_1568 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 22 and 23 216592007836 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.4e-20 216592007837 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216592007838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592007839 Walker A/P-loop; other site 216592007840 ATP binding site [chemical binding]; other site 216592007841 Q-loop/lid; other site 216592007842 ABC transporter signature motif; other site 216592007843 Walker B; other site 216592007844 D-loop; other site 216592007845 H-loop/switch region; other site 216592007846 TOBE domain; Region: TOBE_2; pfam08402 216592007847 HMMPfam hit to PF00005, ABC transporter, score 8.4e-62 216592007848 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007849 PS00211 ABC transporters family signature. 216592007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592007851 dimer interface [polypeptide binding]; other site 216592007852 conserved gate region; other site 216592007853 putative PBP binding loops; other site 216592007854 ABC-ATPase subunit interface; other site 216592007855 PS00430 TonB-dependent receptor proteins signature 1. 216592007856 8 probable transmembrane helices predicted for EC042_1570 by TMHMM2.0 at aa 26-48, 88-110, 123-145, 155-177, 184-206, 229-251, 256-275 and 285-304 216592007857 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.5e-07 216592007858 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592007859 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216592007860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216592007861 6 probable transmembrane helices predicted for EC042_1571 by TMHMM2.0 at aa 12-34, 71-93, 100-122, 132-154, 180-202 and 234-256 216592007862 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-10 216592007863 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592007864 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 216592007865 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 216592007866 tetrameric interface [polypeptide binding]; other site 216592007867 NAD binding site [chemical binding]; other site 216592007868 catalytic residues [active] 216592007869 substrate binding site [chemical binding]; other site 216592007870 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 5e-178 216592007871 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592007872 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 216592007873 trimer interface [polypeptide binding]; other site 216592007874 active site 216592007875 substrate binding site [chemical binding]; other site 216592007876 CoA binding site [chemical binding]; other site 216592007877 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.91 216592007878 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.4 216592007879 PS00101 Hexapeptide-repeat containing-transferases signature. 216592007880 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.8 216592007881 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 216592007882 2 probable transmembrane helices predicted for EC042_1574 by TMHMM2.0 at aa 28-50 and 57-79 216592007883 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 216592007884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 216592007885 5 probable transmembrane helices predicted for EC042_1576 by TMHMM2.0 at aa 7-29, 33-55, 68-90, 94-116 and 123-145 216592007886 HMMPfam hit to PF04657, Protein of unknown function, DUF606, score 3.5e-56 216592007887 Signal peptide predicted for EC042_1576 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.419 between residues 20 and 21 216592007888 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 216592007889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216592007890 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.6e-24 216592007891 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216592007892 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216592007893 NAD(P) binding site [chemical binding]; other site 216592007894 substrate binding site [chemical binding]; other site 216592007895 dimer interface [polypeptide binding]; other site 216592007896 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.6e-35 216592007897 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 216592007898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592007899 DNA-binding site [nucleotide binding]; DNA binding site 216592007900 FCD domain; Region: FCD; pfam07729 216592007901 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.8e-10 216592007902 HMMPfam hit to PF07729, FCD domain, score 2.1e-09 216592007903 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216592007904 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592007905 N-terminal plug; other site 216592007906 ligand-binding site [chemical binding]; other site 216592007907 HMMPfam hit to PF00593, TonB dependent receptor, score 4.5e-34 216592007908 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.6e-25 216592007909 PQQ-like domain; Region: PQQ_2; pfam13360 216592007910 Signal peptide predicted for EC042_1581 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 30 and 31 216592007911 PS00017 ATP/GTP-binding site motif A (P-loop). 216592007912 L-asparagine permease; Provisional; Region: PRK15049 216592007913 HMMPfam hit to PF00324, Amino acid permease, score 5.1e-171 216592007914 12 probable transmembrane helices predicted for EC042_1582 by TMHMM2.0 at aa 54-76, 81-103, 124-146, 161-183, 188-210, 230-252, 277-299, 319-341, 368-390, 394-416, 437-459 and 463-485 216592007915 PS00218 Amino acid permeases signature. 216592007916 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216592007917 C-terminal domain interface [polypeptide binding]; other site 216592007918 GSH binding site (G-site) [chemical binding]; other site 216592007919 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216592007920 dimer interface [polypeptide binding]; other site 216592007921 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216592007922 dimer interface [polypeptide binding]; other site 216592007923 N-terminal domain interface [polypeptide binding]; other site 216592007924 substrate binding pocket (H-site) [chemical binding]; other site 216592007925 PAAR motif; Region: PAAR_motif; pfam05488 216592007926 HMMPfam hit to PF05488, PAAR motif, score 4.9e-08 216592007927 HMMPfam hit to PF05488, PAAR motif, score 5.4e-09 216592007928 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216592007929 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216592007930 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 216592007931 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 5.1e-54 216592007932 HMMPfam hit to PF06715, Gp5 C-terminal repeat (3 copies), score 0.0048 216592007933 HMMPfam hit to PF06715, Gp5 C-terminal repeat (3 copies), score 0.019 216592007934 Sequence divergence between 0157 and Uropathogenic strains, hypothetical proteins 216592007935 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 216592007936 putative active site [active] 216592007937 putative Zn binding site [ion binding]; other site 216592007938 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592007939 Signal peptide predicted for EC042_1587 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.959 between residues 26 and 27 216592007940 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 216592007941 Transposase [DNA replication, recombination, and repair]; Region: COG5433 216592007942 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216592007943 HMMPfam hit to PF01613, Flavin reductase like domain, score 4.7e-06 216592007944 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 216592007945 HMMPfam hit to PF00797, N-acetyltransferase, score 4.1e-100 216592007946 hypothetical protein; Provisional; Region: PRK10281 216592007947 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 9.8e-128 216592007948 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 216592007949 HMMPfam hit to PF02665, Nitrate reductase gamma subunit, score 8.2e-125 216592007950 5 probable transmembrane helices predicted for EC042_1594 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 128-150 and 185-207 216592007951 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 216592007952 HMMPfam hit to PF02613, Nitrate reductase delta subunit, score 1.8e-93 216592007953 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 216592007954 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.014 216592007955 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.015 216592007956 PS00190 Cytochrome c family heme-binding site signature. 216592007957 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 216592007958 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 216592007959 [4Fe-4S] binding site [ion binding]; other site 216592007960 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592007961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592007962 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592007963 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 216592007964 molybdopterin cofactor binding site; other site 216592007965 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 3.7e-44 216592007966 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592007967 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.3e-145 216592007968 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592007969 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592007970 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 216592007971 12 probable transmembrane helices predicted for EC042_1598 by TMHMM2.0 at aa 36-58, 73-95, 102-121, 131-153, 174-196, 211-233, 254-276, 286-306, 313-335, 345-367, 401-423 and 433-455 216592007972 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-10 216592007973 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592007974 Present in 0157, absent in Uropathogenic, hypothetical proteins (x3) and porin 216592007975 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 216592007976 HMMPfam hit to PF00560, Leucine Rich Repeat, score 25 216592007977 HMMPfam hit to PF00560, Leucine Rich Repeat, score 4.8 216592007978 HMMPfam hit to PF00560, Leucine Rich Repeat, score 11 216592007979 HMMPfam hit to PF00560, Leucine Rich Repeat, score 1.4 216592007980 HMMPfam hit to PF00560, Leucine Rich Repeat, score 16 216592007981 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 216592007982 HMMPfam hit to PF00560, Leucine Rich Repeat, score 7.6 216592007983 HMMPfam hit to PF00560, Leucine Rich Repeat, score 18 216592007984 HMMPfam hit to PF00560, Leucine Rich Repeat, score 49 216592007985 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592007986 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592007987 trimer interface [polypeptide binding]; other site 216592007988 eyelet of channel; other site 216592007989 HMMPfam hit to PF00267, Gram-negative porin, score 2.3e-176 216592007990 PS00576 General diffusion Gram-negative porins signature. 216592007991 Signal peptide predicted for EC042_1601 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592007992 aromatic amino acid exporter; Provisional; Region: PRK11689 216592007993 10 probable transmembrane helices predicted for EC042_1602 by TMHMM2.0 at aa 7-24, 34-56, 63-85, 95-113, 120-139, 154-176, 183-205, 215-237, 244-266 and 270-289 216592007994 Signal peptide predicted for EC042_1602 by SignalP 2.0 HMM (Signal peptide probability 0.666) with cleavage site probability 0.101 between residues 26 and 27 216592007995 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 216592007996 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 216592007997 [4Fe-4S] binding site [ion binding]; other site 216592007998 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592007999 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 216592008000 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 216592008001 molybdopterin cofactor binding site; other site 216592008002 Signal peptide predicted for EC042_1604 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.705 between residues 33 and 34 216592008003 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 1.1e-22 216592008004 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592008005 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.1e-43 216592008006 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592008007 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 216592008008 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 216592008009 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 3.1e-05 216592008010 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008011 1 probable transmembrane helix predicted for EC042_1607 by TMHMM2.0 at aa 260-279 216592008012 1 probable transmembrane helix predicted for EC042_1606 by TMHMM2.0 at aa 5-22 216592008013 Signal peptide predicted for EC042_1608 by SignalP 2.0 HMM (Signal peptide probability 0.964) with cleavage site probability 0.450 between residues 47 and 48 216592008014 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 216592008015 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 216592008016 4 probable transmembrane helices predicted for EC042_1608 by TMHMM2.0 at aa 24-46, 61-83, 123-145 and 160-182 216592008017 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 216592008018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592008019 non-specific DNA binding site [nucleotide binding]; other site 216592008020 salt bridge; other site 216592008021 sequence-specific DNA binding site [nucleotide binding]; other site 216592008022 HMMPfam hit to PF01381, Helix-turn-helix, score 4.6e-08 216592008023 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 22-43, sequence VSLREFARAMEIAPSTASRLLT 216592008024 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 216592008025 HMMPfam hit to PF05015, Plasmid maintenance system killer prot, score 2.4e-37 216592008026 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 216592008027 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 216592008028 NAD binding site [chemical binding]; other site 216592008029 substrate binding site [chemical binding]; other site 216592008030 catalytic Zn binding site [ion binding]; other site 216592008031 tetramer interface [polypeptide binding]; other site 216592008032 structural Zn binding site [ion binding]; other site 216592008033 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.7e-103 216592008034 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592008035 PS00190 Cytochrome c family heme-binding site signature. 216592008036 malate dehydrogenase; Provisional; Region: PRK13529 216592008037 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216592008038 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 216592008039 NAD(P) binding site [chemical binding]; other site 216592008040 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 2.7e-139 216592008041 PS00331 Malic enzymes signature. 216592008042 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 2.6e-124 216592008043 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 216592008044 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 216592008045 HMMPfam hit to PF02566, OsmC-like protein, score 2.9e-38 216592008046 Present in 0157, absent in Uropathogenic, ABC transport system and D-Ala-D-Ala dipeptidase, Zn-dependent 216592008047 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216592008048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592008049 Walker A/P-loop; other site 216592008050 ATP binding site [chemical binding]; other site 216592008051 Q-loop/lid; other site 216592008052 ABC transporter signature motif; other site 216592008053 Walker B; other site 216592008054 D-loop; other site 216592008055 H-loop/switch region; other site 216592008056 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216592008057 HMMPfam hit to PF00005, ABC transporter, score 1.6e-56 216592008058 PS00211 ABC transporters family signature. 216592008059 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008060 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216592008061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592008062 Walker A/P-loop; other site 216592008063 ATP binding site [chemical binding]; other site 216592008064 Q-loop/lid; other site 216592008065 ABC transporter signature motif; other site 216592008066 Walker B; other site 216592008067 D-loop; other site 216592008068 H-loop/switch region; other site 216592008069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592008070 HMMPfam hit to PF00005, ABC transporter, score 1.3e-55 216592008071 PS00211 ABC transporters family signature. 216592008072 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008073 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 216592008074 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216592008075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592008076 dimer interface [polypeptide binding]; other site 216592008077 conserved gate region; other site 216592008078 putative PBP binding loops; other site 216592008079 ABC-ATPase subunit interface; other site 216592008080 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.1e-47 216592008081 5 probable transmembrane helices predicted for EC042_1617 by TMHMM2.0 at aa 32-54, 99-121, 142-164, 217-239 and 260-282 216592008082 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592008083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216592008084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592008085 dimer interface [polypeptide binding]; other site 216592008086 conserved gate region; other site 216592008087 putative PBP binding loops; other site 216592008088 ABC-ATPase subunit interface; other site 216592008089 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.9e-55 216592008090 7 probable transmembrane helices predicted for EC042_1618 by TMHMM2.0 at aa 12-34, 103-125, 138-160, 196-218, 247-269, 273-295 and 308-330 216592008091 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592008092 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216592008093 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216592008094 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.7e-87 216592008095 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592008096 1 probable transmembrane helix predicted for EC042_1619 by TMHMM2.0 at aa 50-72 216592008097 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 216592008098 HMMPfam hit to PF01427, D-ala-D-ala dipeptidase, score 3.8e-116 216592008099 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 216592008100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592008101 putative active site [active] 216592008102 heme pocket [chemical binding]; other site 216592008103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592008104 putative active site [active] 216592008105 heme pocket [chemical binding]; other site 216592008106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592008107 metal binding site [ion binding]; metal-binding site 216592008108 active site 216592008109 I-site; other site 216592008110 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592008111 HMMPfam hit to PF00563, EAL domain, score 8.8e-124 216592008112 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-17 216592008113 HMMPfam hit to PF00785, PAC motif, score 3.9e-07 216592008114 HMMPfam hit to PF00785, PAC motif, score 0.36 216592008115 HMMPfam hit to PF00989, PAS domain, score 2.3e-09 216592008116 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 216592008117 heme-binding site [chemical binding]; other site 216592008118 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592008119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592008120 metal binding site [ion binding]; metal-binding site 216592008121 active site 216592008122 I-site; other site 216592008123 HMMPfam hit to PF00990, GGDEF domain, score 1.9e-72 216592008124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 216592008125 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 216592008126 HMMPfam hit to PF02638, Uncharacterized BCR, COG1649, score 4.4e-302 216592008127 Signal peptide predicted for EC042_1623 by SignalP 2.0 HMM (Signal peptide probability 0.646) with cleavage site probability 0.232 between residues 43 and 44 216592008128 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592008129 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 216592008130 HMMPfam hit to PF00324, Amino acid permease, score 2e-05 216592008131 12 probable transmembrane helices predicted for EC042_1624 by TMHMM2.0 at aa 13-30, 40-62, 95-117, 132-151, 158-180, 195-217, 238-260, 288-310, 335-357, 372-394, 407-429 and 444-466 216592008132 Signal peptide predicted for EC042_1624 by SignalP 2.0 HMM (Signal peptide probability 0.948) with cleavage site probability 0.747 between residues 28 and 29 216592008133 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 216592008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592008135 catalytic residue [active] 216592008136 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 2.1e-176 216592008137 PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 216592008138 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592008139 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216592008140 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216592008141 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216592008142 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216592008143 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216592008144 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 3.8e-18 216592008145 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 9e-31 216592008146 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 3.9e-58 216592008147 PS00143 Insulinase family, zinc-binding region signature. 216592008148 1 probable transmembrane helix predicted for EC042_1626 by TMHMM2.0 at aa 13-35 216592008149 Signal peptide predicted for EC042_1626 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.931 between residues 22 and 23 216592008150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216592008151 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216592008152 HMMPfam hit to PF00593, TonB dependent receptor, score 1.6e-11 216592008153 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008154 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 1.1e-14 216592008155 Signal peptide predicted for EC042_1627 by SignalP 2.0 HMM (Signal peptide probability 0.875) with cleavage site probability 0.481 between residues 19 and 20 216592008156 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216592008157 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 216592008158 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 216592008159 HMMPfam hit to PF00005, ABC transporter, score 8e-42 216592008160 PS00211 ABC transporters family signature. 216592008161 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008162 5 probable transmembrane helices predicted for EC042_1628 by TMHMM2.0 at aa 30-52, 72-94, 151-173, 188-210 and 284-306 216592008163 Signal peptide predicted for EC042_1628 by SignalP 2.0 HMM (Signal peptide probability 0.755) with cleavage site probability 0.501 between residues 47 and 48 216592008164 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 216592008165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592008166 FeS/SAM binding site; other site 216592008167 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 216592008168 HMMPfam hit to PF04055, Radical SAM superfamily, score 8.9e-23 216592008169 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216592008170 Sulfatase; Region: Sulfatase; pfam00884 216592008171 HMMPfam hit to PF00884, Sulfatase, score 4.8e-94 216592008172 PS00149 Sulfatases signature 2. 216592008173 Signal peptide predicted for EC042_1630 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 29 and 30 216592008174 transcriptional regulator YdeO; Provisional; Region: PRK09940 216592008175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592008176 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-06 216592008177 PS00041 Bacterial regulatory proteins, araC family signature. 216592008178 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 7.7e-05 216592008179 Predicted helix-turn-helix motif with score 1212.000, SD 3.31 at aa 42-172, sequence EPYERHFKEIGFNENTIKKYLQCTNIQTVTVPVPAKFLRASNVPTGLLNEMIAYLNS EERNHHNFSELLLFSCLSIFAACKGFITLLTNGVLSVSGKVRNIVNMKLAHPWKLKD ICDCLYISESLLKKKLK 216592008180 Predicted helix-turn-helix motif with score 1212.000, SD 3.31 at aa 151-172, sequence WKLKDICDCLYISESLLKKKLK 216592008181 Predicted helix-turn-helix motif with score 991.000, SD 3.31 at aa 42-63, sequence EPYERHFKEIGFNENTIKKYLQ 216592008182 1 probable transmembrane helix predicted for EC042_1632 by TMHMM2.0 at aa 21-40 216592008183 Signal peptide predicted for EC042_1632 by SignalP 2.0 HMM (Signal peptide probability 0.830) with cleavage site probability 0.745 between residues 39 and 40 216592008184 putative oxidoreductase; Provisional; Region: PRK09939 216592008185 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 216592008186 putative molybdopterin cofactor binding site [chemical binding]; other site 216592008187 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 216592008188 putative molybdopterin cofactor binding site; other site 216592008189 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.5e-10 216592008190 Fimbrial operon 6 216592008191 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 216592008192 mannosyl binding site [chemical binding]; other site 216592008193 Fimbrial protein; Region: Fimbrial; cl01416 216592008194 HMMPfam hit to PF00419, Fimbrial protein, score 0.00045 216592008195 Signal peptide predicted for EC042_1634 by SignalP 2.0 HMM (Signal peptide probability 0.972) with cleavage site probability 0.645 between residues 24 and 25 216592008196 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592008197 HMMPfam hit to PF00419, Fimbrial protein, score 1.9e-06 216592008198 Signal peptide predicted for EC042_1635 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 23 and 24 216592008199 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592008200 HMMPfam hit to PF00419, Fimbrial protein, score 7.1e-35 216592008201 1 probable transmembrane helix predicted for EC042_1636 by TMHMM2.0 at aa 5-27 216592008202 Signal peptide predicted for EC042_1636 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.708 between residues 22 and 23 216592008203 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216592008204 PapC N-terminal domain; Region: PapC_N; pfam13954 216592008205 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592008206 PapC C-terminal domain; Region: PapC_C; pfam13953 216592008207 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592008208 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592008209 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592008210 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 216592008211 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592008212 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592008213 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.1e-21 216592008214 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 2.7e-58 216592008215 PS00635 Gram-negative pili assembly chaperone signature. 216592008216 1 probable transmembrane helix predicted for EC042_1638 by TMHMM2.0 at aa 13-35 216592008217 Signal peptide predicted for EC042_1638 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.953 between residues 34 and 35 216592008218 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592008219 Fimbrial protein; Region: Fimbrial; cl01416 216592008220 HMMPfam hit to PF00419, Fimbrial protein, score 5.2e-60 216592008221 Signal peptide predicted for EC042_1639 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.916 between residues 39 and 40 216592008222 Helix-turn-helix domain; Region: HTH_18; pfam12833 216592008223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592008224 HipA N-terminal domain; Region: Couple_hipA; pfam13657 216592008225 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 216592008226 HipA-like N-terminal domain; Region: HipA_N; pfam07805 216592008227 HipA-like C-terminal domain; Region: HipA_C; pfam07804 216592008228 Present in 0157, absent in Uropathogenic, misc region (Pertactin domain protein (pseudogene?), carbohydrate kinase, regulators, ABC transporter, aldolase) 216592008229 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 216592008230 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592008231 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592008232 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592008233 HMMPfam hit to PF03212, Pertactin, score 1.2e-05 216592008234 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008235 HMMPfam hit to PF05594, no description, score 10 216592008236 Signal peptide predicted for EC042_1643 by SignalP 2.0 HMM (Signal peptide probability 0.840) with cleavage site probability 0.753 between residues 61 and 62 216592008237 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592008238 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 216592008239 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 216592008240 putative N- and C-terminal domain interface [polypeptide binding]; other site 216592008241 putative active site [active] 216592008242 putative MgATP binding site [chemical binding]; other site 216592008243 catalytic site [active] 216592008244 metal binding site [ion binding]; metal-binding site 216592008245 putative carbohydrate binding site [chemical binding]; other site 216592008246 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 4.9e-11 216592008247 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 3.9e-47 216592008248 transcriptional regulator LsrR; Provisional; Region: PRK15418 216592008249 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 216592008250 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216592008251 HMMPfam hit to PF04198, Putative sugar-binding domain, score 7.1e-98 216592008252 Predicted helix-turn-helix motif with score 1772.000, SD 5.22 at aa 31-52, sequence LTQSEISDRLGLTRLKVSRLLE 216592008253 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 216592008254 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592008255 Walker A/P-loop; other site 216592008256 ATP binding site [chemical binding]; other site 216592008257 Q-loop/lid; other site 216592008258 ABC transporter signature motif; other site 216592008259 Walker B; other site 216592008260 D-loop; other site 216592008261 H-loop/switch region; other site 216592008262 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592008263 HMMPfam hit to PF00005, ABC transporter, score 2.3e-44 216592008264 HMMPfam hit to PF00005, ABC transporter, score 1.3e-27 216592008265 PS00211 ABC transporters family signature. 216592008266 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592008267 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592008268 TM-ABC transporter signature motif; other site 216592008269 Signal peptide predicted for EC042_1647 by SignalP 2.0 HMM (Signal peptide probability 0.883) with cleavage site probability 0.209 between residues 27 and 28 216592008270 9 probable transmembrane helices predicted for EC042_1647 by TMHMM2.0 at aa 13-27, 37-59, 66-85, 90-112, 119-141, 156-178, 208-230, 250-272 and 279-301 216592008271 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 4.5e-52 216592008272 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592008273 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592008274 TM-ABC transporter signature motif; other site 216592008275 9 probable transmembrane helices predicted for EC042_1648 by TMHMM2.0 at aa 7-26, 36-58, 65-84, 88-110, 123-145, 160-182, 211-233, 248-279 and 292-311 216592008276 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 3.2e-66 216592008277 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 216592008278 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 216592008279 ligand binding site [chemical binding]; other site 216592008280 Signal peptide predicted for EC042_1649 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 26 and 27 216592008281 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 216592008282 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 216592008283 putative active site; other site 216592008284 catalytic residue [active] 216592008285 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592008286 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 216592008287 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 7.4e-19 216592008288 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 216592008289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592008290 S-adenosylmethionine binding site [chemical binding]; other site 216592008291 Predicted membrane protein [Function unknown]; Region: COG3781 216592008292 HMMPfam hit to PF05249, Uncharacterised protein family (UPF0187), score 1.5e-201 216592008293 3 probable transmembrane helices predicted for EC042_1653 by TMHMM2.0 at aa 45-64, 69-91 and 235-257 216592008294 altronate oxidoreductase; Provisional; Region: PRK03643 216592008295 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216592008296 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216592008297 HMMPfam hit to PF01232, Mannitol dehydrogenase, score 1.8e-185 216592008298 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592008299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592008300 metal binding site [ion binding]; metal-binding site 216592008301 active site 216592008302 I-site; other site 216592008303 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-55 216592008304 8 probable transmembrane helices predicted for EC042_1655 by TMHMM2.0 at aa 15-37, 44-63, 87-109, 128-150, 170-189, 196-218, 233-255 and 268-290 216592008305 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 216592008306 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 216592008307 glutaminase; Provisional; Region: PRK00971 216592008308 HMMPfam hit to PF04960, Glutaminase, score 5.3e-192 216592008309 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 216592008310 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 216592008311 NAD(P) binding site [chemical binding]; other site 216592008312 catalytic residues [active] 216592008313 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 3.5e-133 216592008314 PS00070 Aldehyde dehydrogenases cysteine active site. 216592008315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592008316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592008317 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 216592008318 putative dimerization interface [polypeptide binding]; other site 216592008319 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.7e-18 216592008320 PS00044 Bacterial regulatory proteins, lysR family signature. 216592008321 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.7e-50 216592008322 putative arabinose transporter; Provisional; Region: PRK03545 216592008323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592008324 putative substrate translocation pore; other site 216592008325 12 probable transmembrane helices predicted for EC042_1661 by TMHMM2.0 at aa 12-34, 49-71, 80-99, 104-126, 138-160, 170-192, 204-226, 246-265, 272-294, 304-326, 333-352 and 362-384 216592008326 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.4e-41 216592008327 inner membrane protein; Provisional; Region: PRK10995 216592008328 HMMPfam hit to PF01914, MarC family integral membrane protein, score 1e-105 216592008329 5 probable transmembrane helices predicted for EC042_1662 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 150-172 and 192-214 216592008330 Signal peptide predicted for EC042_1662 by SignalP 2.0 HMM (Signal peptide probability 0.647) with cleavage site probability 0.253 between residues 19 and 20 216592008331 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 216592008332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216592008333 HMMPfam hit to PF01047, MarR family, score 2.7e-36 216592008334 PS01117 Bacterial regulatory proteins, marR family signature. 216592008335 PS00190 Cytochrome c family heme-binding site signature. 216592008336 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 216592008337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592008338 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.7e-13 216592008339 Predicted helix-turn-helix motif with score 1423.000, SD 4.03 at aa 26-47, sequence LSLEKVSERSGYSKWHLQRMFK 216592008340 PS00041 Bacterial regulatory proteins, araC family signature. 216592008341 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.2e-10 216592008342 hypothetical protein; Provisional; Region: PRK10106 216592008343 Signal peptide predicted for EC042_1665 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.952 between residues 21 and 22 216592008344 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 216592008345 EamA-like transporter family; Region: EamA; pfam00892 216592008346 EamA-like transporter family; Region: EamA; pfam00892 216592008347 10 probable transmembrane helices predicted for EC042_1666 by TMHMM2.0 at aa 13-30, 40-59, 68-90, 94-116, 123-142, 147-169, 181-203, 218-240, 253-270 and 274-296 216592008348 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.4e-20 216592008349 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.9e-13 216592008350 putative transporter; Provisional; Region: PRK10054 216592008351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592008352 putative substrate translocation pore; other site 216592008353 Signal peptide predicted for EC042_1667 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.485 between residues 24 and 25 216592008354 12 probable transmembrane helices predicted for EC042_1667 by TMHMM2.0 at aa 12-34, 44-66, 75-94, 99-121, 134-156, 160-182, 208-230, 245-264, 271-293, 298-320, 341-360 and 364-381 216592008355 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.4e-37 216592008356 diguanylate cyclase; Provisional; Region: PRK09894 216592008357 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 216592008358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592008359 metal binding site [ion binding]; metal-binding site 216592008360 active site 216592008361 I-site; other site 216592008362 HMMPfam hit to PF00990, GGDEF domain, score 6e-67 216592008363 hypothetical protein; Provisional; Region: PRK10053 216592008364 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 4.4e-75 216592008365 Signal peptide predicted for EC042_1669 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 19 and 20 216592008366 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 216592008367 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 216592008368 active site 216592008369 Zn binding site [ion binding]; other site 216592008370 HMMPfam hit to PF01432, Peptidase family M3, score 2e-207 216592008371 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592008372 malonic semialdehyde reductase; Provisional; Region: PRK10538 216592008373 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 216592008374 putative NAD(P) binding site [chemical binding]; other site 216592008375 homodimer interface [polypeptide binding]; other site 216592008376 homotetramer interface [polypeptide binding]; other site 216592008377 active site 216592008378 HMMPfam hit to PF00106, short chain dehydrogenase, score 9.3e-66 216592008379 PS00061 Short-chain dehydrogenases/reductases family signature. 216592008380 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216592008381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592008382 DNA-binding site [nucleotide binding]; DNA binding site 216592008383 FCD domain; Region: FCD; pfam07729 216592008384 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 4.1e-19 216592008385 PS00043 Bacterial regulatory proteins, gntR family signature. 216592008386 Predicted helix-turn-helix motif with score 973.000, SD 2.50 at aa 36-57, sequence LSEKEVSVRFNVSRQPVREAFI 216592008387 HMMPfam hit to PF07729, FCD domain, score 7.8e-16 216592008388 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 216592008389 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216592008390 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216592008391 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216592008392 HMMPfam hit to PF01232, Mannitol dehydrogenase, score 7.7e-260 216592008393 PS00974 Mannitol dehydrogenases signature. 216592008394 metabolite-proton symporter; Region: 2A0106; TIGR00883 216592008395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592008396 putative substrate translocation pore; other site 216592008397 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.1e-07 216592008398 9 probable transmembrane helices predicted for EC042_1675 by TMHMM2.0 at aa 27-49, 61-83, 131-153, 160-182, 254-273, 280-299, 309-331, 352-371 and 375-394 216592008399 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-19 216592008400 prophage 4. Absent in Uropathogenic, divergent in 0157, carrying exonuclease, edge of rearrangement in 0157 (EDL, not Sakai), other edge see 042_ROD18 216592008401 multiple promoter invertase; Provisional; Region: mpi; PRK13413 216592008402 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216592008403 catalytic residues [active] 216592008404 catalytic nucleophile [active] 216592008405 Presynaptic Site I dimer interface [polypeptide binding]; other site 216592008406 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216592008407 Synaptic Flat tetramer interface [polypeptide binding]; other site 216592008408 Synaptic Site I dimer interface [polypeptide binding]; other site 216592008409 DNA binding site [nucleotide binding] 216592008410 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216592008411 DNA-binding interface [nucleotide binding]; DNA binding site 216592008412 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 8.3e-60 216592008413 PS00398 Site-specific recombinases signature 2. 216592008414 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 6.8e-12 216592008415 Predicted helix-turn-helix motif with score 1589.000, SD 4.60 at aa 168-189, sequence VSISAIAREFKTSRQTILRAKA 216592008416 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 216592008417 HMMPfam hit to PF02413, Caudovirales tail fibre assembly protein, score 2.5e-64 216592008418 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 216592008419 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 216592008420 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 216592008421 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 216592008422 Phage Tail Collar Domain; Region: Collar; pfam07484 216592008423 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.6 216592008424 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.65 216592008425 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.11 216592008426 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.97 216592008427 HMMPfam hit to PF03335, Phage tail fibre repeat, score 0.024 216592008428 HMMPfam hit to PF03335, Phage tail fibre repeat, score 1.1 216592008429 HMMPfam hit to PF07484, Phage Tail Collar Domain, score 5.6e-23 216592008430 HMMPfam hit to PF03406, Phage tail fibre repeat, score 4.2e-17 216592008431 HMMPfam hit to PF03406, Phage tail fibre repeat, score 1e-16 216592008432 HMMPfam hit to PF03406, Phage tail fibre repeat, score 8.6e-17 216592008433 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 216592008434 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 4.4e-151 216592008435 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216592008436 PS00694 Enterobacterial virulence outer membrane protein signature 1. 216592008437 Signal peptide predicted for EC042_1680 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 24 and 25 216592008438 Phage-related protein, tail component [Function unknown]; Region: COG4733 216592008439 Putative phage tail protein; Region: Phage-tail_3; pfam13550 216592008440 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 216592008441 Fibronectin type III protein; Region: DUF3672; pfam12421 216592008442 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0041 216592008443 Phage-related protein, tail component [Function unknown]; Region: COG4723 216592008444 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly prot, score 2.9e-124 216592008445 2 probable transmembrane helices predicted for EC042_1682 by TMHMM2.0 at aa 102-124 and 129-151 216592008446 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 216592008447 MPN+ (JAMM) motif; other site 216592008448 Zinc-binding site [ion binding]; other site 216592008449 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592008450 NlpC/P60 family; Region: NLPC_P60; cl17555 216592008451 HMMPfam hit to PF00877, NlpC/P60 family, score 1.3e-24 216592008452 Phage-related protein [Function unknown]; Region: gp18; COG4672 216592008453 HMMPfam hit to PF05100, Phage minor tail protein L, score 9e-150 216592008454 Phage-related protein [Function unknown]; Region: COG4718 216592008455 HMMPfam hit to PF05939, Phage minor tail protein, score 3.3e-65 216592008457 HMMPfam hit to PF06791, Prophage tail length tape measure protein, score 7.9e-27 216592008458 Minor tail protein T; Region: Phage_tail_T; pfam06223 216592008459 HMMPfam hit to PF06223, Minor tail protein T, score 9.8e-74 216592008460 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 216592008461 HMMPfam hit to PF06894, Bacteriophage lambda minor tail prote, score 1.4e-96 216592008462 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 216592008463 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 216592008464 HMMPfam hit to PF02368, Bacterial Ig-like domain (group 2), score 7.6e-19 216592008465 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 216592008466 HMMPfam hit to PF06141, Phage minor tail protein U, score 1e-88 216592008467 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 216592008468 HMMPfam hit to PF06763, Prophage minor tail protein Z (GPZ), score 2.9e-134 216592008469 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 216592008470 HMMPfam hit to PF05354, Phage Head-Tail Attachment, score 1.2e-91 216592008471 DNA packaging protein FI; Region: Packaging_FI; pfam14000 216592008472 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 216592008473 HMMPfam hit to PF03864, Phage major capsid protein E, score 6.8e-289 216592008474 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 216592008475 HMMPfam hit to PF02924, Bacteriophage lambda head decoration protein, score 7.4e-74 216592008476 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 216592008477 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 216592008478 tandem repeat interface [polypeptide binding]; other site 216592008479 oligomer interface [polypeptide binding]; other site 216592008480 active site residues [active] 216592008481 HMMPfam hit to PF01343, Peptidase family S49, score 5.3e-63 216592008482 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 216592008483 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 216592008484 HMMPfam hit to PF05136, Phage portal protein, lambda family, score 3.9e-221 216592008485 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 216592008486 HMMPfam hit to PF05876, Phage terminase large subunit (GpA), score 0 216592008487 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 216592008488 HMMPfam hit to PF07471, Phage DNA packaging protein Nu1, score 1.9e-122 216592008489 Predicted helix-turn-helix motif with score 1763.000, SD 5.19 at aa 3-24, sequence VNKKQLADIFGASIRTIQNWQE 216592008490 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 216592008491 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 216592008492 HMMPfam hit to PF07166, Protein of unknown function (DUF1398), score 5.9e-95 216592008493 GnsA/GnsB family; Region: GnsAB; pfam08178 216592008494 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592008495 DNA-binding site [nucleotide binding]; DNA binding site 216592008496 RNA-binding motif; other site 216592008497 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 216592008498 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 216592008499 catalytic residues [active] 216592008500 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 216592008501 Lysis protein S; Region: Lysis_S; pfam04971 216592008502 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592008503 DNA-binding site [nucleotide binding]; DNA binding site 216592008504 RNA-binding motif; other site 216592008505 Antitermination protein; Region: Antiterm; pfam03589 216592008506 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216592008507 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 216592008508 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216592008509 HMMPfam hit to PF03589, Antitermination protein, score 4.1e-55 216592008510 PS00190 Cytochrome c family heme-binding site signature. 216592008511 HMMPfam hit to PF03589, Antitermination protein, score 6.5e-54 216592008512 Protein of unknown function (DUF968); Region: DUF968; pfam06147 216592008513 HMMPfam hit to PF06914, Protein of unknown function (DUF1277), score 8.3e-232 216592008514 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 216592008515 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 1.7e-16 216592008516 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 216592008517 HMMPfam hit to PF04221, RelB antitoxin, score 1.7e-38 216592008519 Homeodomain-like domain; Region: HTH_23; pfam13384 216592008520 Winged helix-turn helix; Region: HTH_29; pfam13551 216592008521 Homeodomain-like domain; Region: HTH_32; pfam13565 216592008522 Integrase core domain; Region: rve; pfam00665 216592008523 Integrase core domain; Region: rve_3; cl15866 216592008524 HMMPfam hit to PF00665, Integrase core domain, score 1.2e-16 216592008525 Predicted helix-turn-helix motif with score 1456.000, SD 4.15 at aa 18-39, sequence IIQEQAAARIGISIRQVKRLVQ 216592008527 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 216592008528 HMMPfam hit to PF06163, Bacterial protein of unknown function (DUF97, score 1.9e-103 216592008529 primosomal protein DnaI; Provisional; Region: PRK02854 216592008530 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 216592008531 HMMPfam hit to PF06254, Protein of unknown function (DUF1019), score 2.9e-86 216592008532 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 216592008533 Predicted helix-turn-helix motif with score 1307.000, SD 3.64 at aa 11-32, sequence GSKTKLAQAAGIRLASLYSWKG 216592008534 transcriptional repressor DicA; Reviewed; Region: PRK09706 216592008535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592008536 non-specific DNA binding site [nucleotide binding]; other site 216592008537 salt bridge; other site 216592008538 sequence-specific DNA binding site [nucleotide binding]; other site 216592008539 HMMPfam hit to PF01381, Helix-turn-helix, score 1.2e-15 216592008540 Predicted helix-turn-helix motif with score 2271.000, SD 6.92 at aa 21-42, sequence HTQRSLAKALKISHVSVSQWER 216592008541 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 216592008542 HMMPfam hit to PF07151, Protein of unknown function (DUF1391), score 1.1e-38 216592008543 DicB protein; Region: DicB; pfam05358 216592008544 HMMPfam hit to PF05358, DicB protein, score 1.1e-51 216592008545 Signal peptide predicted for EC042_1723 by SignalP 2.0 HMM (Signal peptide probability 0.633) with cleavage site probability 0.557 between residues 19 and 20 216592008546 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 216592008547 HMMPfam hit to PF07358, Protein of unknown function (DUF1482), score 1.1e-40 216592008548 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 216592008549 active site 216592008550 catalytic site [active] 216592008551 substrate binding site [chemical binding]; other site 216592008552 HMMPfam hit to PF00929, Exonuclease, score 0.0056 216592008553 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 216592008554 HMMPfam hit to PF06806, Putative excisionase (DUF1233), score 6.8e-57 216592008555 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 216592008556 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216592008557 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 216592008558 Int/Topo IB signature motif; other site 216592008559 HMMPfam hit to PF00589, Phage integrase family, score 3.3e-09 216592008560 putative oxidoreductase; Provisional; Region: PRK10083 216592008561 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 216592008562 putative NAD(P) binding site [chemical binding]; other site 216592008563 catalytic Zn binding site [ion binding]; other site 216592008564 structural Zn binding site [ion binding]; other site 216592008565 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 4.3e-88 216592008566 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592008567 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 216592008568 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 216592008569 putative active site pocket [active] 216592008570 putative metal binding site [ion binding]; other site 216592008571 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 5.8e-162 216592008572 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 216592008573 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 1.9e-60 216592008574 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216592008575 hypothetical protein; Provisional; Region: PRK02237 216592008576 HMMPfam hit to PF02694, Uncharacterized BCR, YnfA/UPF0060 family, score 2.4e-75 216592008577 4 probable transmembrane helices predicted for EC042_1729 by TMHMM2.0 at aa 7-29, 33-55, 62-81 and 91-109 216592008578 hypothetical protein; Provisional; Region: PRK13659 216592008579 Signal peptide predicted for EC042_1730 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 28 and 29 216592008580 HMMPfam hit to PF06932, Protein of unknown function (DUF1283), score 2.1e-87 216592008581 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 216592008582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592008583 Coenzyme A binding pocket [chemical binding]; other site 216592008584 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.8e-21 216592008585 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 216592008586 HMMPfam hit to PF06788, Uncharacterised protein family (UPF0257), score 1e-196 216592008587 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 216592008588 HMMPfam hit to PF06649, Protein of unknown function (DUF1161), score 2e-45 216592008589 1 probable transmembrane helix predicted for EC042_1733 by TMHMM2.0 at aa 13-35 216592008590 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 216592008591 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 216592008592 putative [Fe4-S4] binding site [ion binding]; other site 216592008593 putative molybdopterin cofactor binding site [chemical binding]; other site 216592008594 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 216592008595 putative molybdopterin cofactor binding site; other site 216592008596 Signal peptide predicted for EC042_1734 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.633 between residues 42 and 43 216592008597 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 3.8e-15 216592008598 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.2e-141 216592008599 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592008600 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.3e-46 216592008601 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592008602 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 216592008603 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 216592008604 putative [Fe4-S4] binding site [ion binding]; other site 216592008605 putative molybdopterin cofactor binding site [chemical binding]; other site 216592008606 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 216592008607 putative molybdopterin cofactor binding site; other site 216592008608 Signal peptide predicted for EC042_1735 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 46 and 47 216592008609 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 8.5e-13 216592008610 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592008611 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 9.8e-135 216592008612 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.1e-43 216592008613 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 216592008614 4Fe-4S binding domain; Region: Fer4; cl02805 216592008615 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.014 216592008616 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 3.8e-07 216592008617 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008618 PS00190 Cytochrome c family heme-binding site signature. 216592008619 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 216592008620 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 6.9e-176 216592008621 8 probable transmembrane helices predicted for EC042_1737 by TMHMM2.0 at aa 10-32, 45-67, 87-106, 113-132, 147-169, 181-203, 223-243 and 250-272 216592008622 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 216592008623 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 3.4e-56 216592008624 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216592008625 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 216592008626 Cl- selectivity filter; other site 216592008627 Cl- binding residues [ion binding]; other site 216592008628 pore gating glutamate residue; other site 216592008629 dimer interface [polypeptide binding]; other site 216592008630 Signal peptide predicted for EC042_1740 by SignalP 2.0 HMM (Signal peptide probability 0.880) with cleavage site probability 0.688 between residues 45 and 46 216592008631 10 probable transmembrane helices predicted for EC042_1740 by TMHMM2.0 at aa 25-47, 74-91, 166-188, 198-220, 241-260, 280-302, 309-331, 341-363, 370-392 and 402-424 216592008632 HMMPfam hit to PF00654, Voltage gated chloride channel, score 9.1e-17 216592008633 putative dithiobiotin synthetase; Provisional; Region: PRK12374 216592008634 AAA domain; Region: AAA_26; pfam13500 216592008635 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 1.1e-29 216592008636 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008637 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 216592008638 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216592008639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592008640 nucleotide binding site [chemical binding]; other site 216592008641 HMMPfam hit to PF00480, ROK family, score 3.6e-33 216592008642 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 216592008643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592008644 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216592008645 dimerization interface [polypeptide binding]; other site 216592008646 substrate binding pocket [chemical binding]; other site 216592008647 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.3e-53 216592008648 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-19 216592008649 PS00044 Bacterial regulatory proteins, lysR family signature. 216592008650 Predicted helix-turn-helix motif with score 1561.000, SD 4.50 at aa 18-39, sequence LHFGRAAARLNISQPPLSQQIQ 216592008651 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216592008652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592008653 putative substrate translocation pore; other site 216592008654 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00013 216592008655 12 probable transmembrane helices predicted for EC042_1744 by TMHMM2.0 at aa 37-59, 74-95, 102-124, 128-150, 157-179, 189-211, 240-262, 272-291, 304-323, 328-350, 363-385 and 389-411 216592008656 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.4e-45 216592008657 PS00216 Sugar transport proteins signature 1. 216592008658 Signal peptide predicted for EC042_1745 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 21 an 22 216592008659 1 probable transmembrane helix predicted for EC042_1745 by TMHMM2.0 at aa 13-35 216592008660 HMMPfam hit to PF06392, Acid shock protein repeat, score 0.0048 216592008661 HMMPfam hit to PF06392, Acid shock protein repeat, score 0.021 216592008662 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 216592008663 Signal peptide predicted for EC042_1746 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592008664 HMMPfam hit to PF00089, Trypsin, score 3.8e-05 216592008665 PS00134 Serine proteases, trypsin family, histidine active site. 216592008666 PS00135 Serine proteases, trypsin family, serine active site. 216592008667 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 216592008668 4 probable transmembrane helices predicted for EC042_1747 by TMHMM2.0 at aa 10-29, 36-53, 63-85 and 92-106 216592008669 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 8e-47 216592008670 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 216592008671 4 probable transmembrane helices predicted for EC042_1748 by TMHMM2.0 at aa 2-20, 30-52, 57-79 and 83-102 216592008672 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 7.9e-39 216592008673 This CDS is disrupted by the insertion of a prophage 216592008674 prophage like region. Unique to 042 216592008675 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 216592008676 HMMPfam hit to PF02924, Bacteriophage lambda head decoration protein, score 9.7e-08 216592008677 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 216592008678 HMMPfam hit to PF03864, Phage major capsid protein E, score 1.1e-101 216592008679 PerC transcriptional activator; Region: PerC; pfam06069 216592008680 HMMPfam hit to PF06069, PerC transcriptional activator, score 1.3e-61 216592008681 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216592008682 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592008683 ssDNA binding site [nucleotide binding]; other site 216592008684 dimer interface [polypeptide binding]; other site 216592008685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592008686 HMMPfam hit to PF00436, Single-strand binding protein family, score 7.2e-13 216592008687 AAA domain; Region: AAA_25; pfam13481 216592008688 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216592008689 Walker A motif; other site 216592008690 ATP binding site [chemical binding]; other site 216592008691 Walker B motif; other site 216592008692 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592008693 PS00228 Tubulin-beta mRNA autoregulation signal. 216592008694 PS00761 Signal peptidases I signature 3. 216592008695 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 216592008696 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 4.5e-27 216592008697 Predicted helix-turn-helix motif with score 1066.000, SD 2.82 at aa 8-29, sequence IREKECEKLTGLSRTCRYRLEK 216592008698 integrase; Provisional; Region: PRK09692 216592008699 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592008700 active site 216592008701 Int/Topo IB signature motif; other site 216592008702 HMMPfam hit to PF00589, Phage integrase family, score 3.3e-18 216592008703 2 probable transmembrane helices predicted for EC042_1768 by TMHMM2.0 at aa 9-28 and 43-62 216592008704 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 5.4e-61 216592008705 Signal peptide predicted for EC042_1769 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.450 between residues 35 and 36 216592008706 6 probable transmembrane helices predicted for EC042_1769 by TMHMM2.0 at aa 9-31, 91-113, 143-165, 169-191, 204-226 and 246-268 216592008707 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 216592008708 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 216592008709 HMMPfam hit to PF02233, NAD(P) transhydrogenase beta subunit, score 0 216592008710 9 probable transmembrane helices predicted for EC042_1770 by TMHMM2.0 at aa 5-24, 33-52, 57-75, 88-107, 122-144, 164-181, 185-207, 214-236 and 240-259 216592008711 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 216592008712 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 216592008713 ligand binding site [chemical binding]; other site 216592008714 homodimer interface [polypeptide binding]; other site 216592008715 NAD(P) binding site [chemical binding]; other site 216592008716 trimer interface B [polypeptide binding]; other site 216592008717 trimer interface A [polypeptide binding]; other site 216592008718 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 216592008719 5 probable transmembrane helices predicted for EC042_1771 by TMHMM2.0 at aa 187-209, 421-438, 442-464, 471-490 and 495-517 216592008720 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal dom, score 3.1e-114 216592008721 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 216592008722 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal dom, score 8.5e-76 216592008723 PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 216592008724 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592008725 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592008726 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592008727 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.6e-10 216592008728 Signal peptide predicted for EC042_1772 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.993 between residues 22 and 23 216592008729 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 0.00064 216592008730 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 216592008731 Spore germination protein; Region: Spore_permease; cl17796 216592008732 Signal peptide predicted for EC042_1773 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.390 between residues 34 and 35 216592008733 13 probable transmembrane helices predicted for EC042_1773 by TMHMM2.0 at aa 5-27, 37-59, 90-112, 127-149, 156-178, 203-222, 235-257, 277-299, 329-351, 356-378, 385-403, 407-426 and 442-459 216592008734 HMMPfam hit to PF00324, Amino acid permease, score 6.1e-05 216592008735 dihydromonapterin reductase; Provisional; Region: PRK06483 216592008736 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 216592008737 NADP binding site [chemical binding]; other site 216592008738 substrate binding pocket [chemical binding]; other site 216592008739 active site 216592008740 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.5e-07 216592008741 PS00061 Short-chain dehydrogenases/reductases family signature. 216592008742 GlpM protein; Region: GlpM; pfam06942 216592008743 HMMPfam hit to PF06942, GlpM protein, score 3.4e-81 216592008744 4 probable transmembrane helices predicted for EC042_1775 by TMHMM2.0 at aa 4-21, 28-47, 57-79 and 86-108 216592008745 Signal peptide predicted for EC042_1775 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.976 between residues 21 and 22 216592008746 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 216592008747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592008748 active site 216592008749 phosphorylation site [posttranslational modification] 216592008750 intermolecular recognition site; other site 216592008751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592008752 DNA binding site [nucleotide binding] 216592008753 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.7e-22 216592008754 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.9e-19 216592008755 sensor protein RstB; Provisional; Region: PRK10604 216592008756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592008757 dimerization interface [polypeptide binding]; other site 216592008758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592008759 dimer interface [polypeptide binding]; other site 216592008760 phosphorylation site [posttranslational modification] 216592008761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592008762 ATP binding site [chemical binding]; other site 216592008763 Mg2+ binding site [ion binding]; other site 216592008764 G-X-G motif; other site 216592008765 Signal peptide predicted for EC042_1777 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.475 between residues 28 and 29 216592008766 2 probable transmembrane helices predicted for EC042_1777 by TMHMM2.0 at aa 5-27 and 139-156 216592008767 HMMPfam hit to PF00672, HAMP domain, score 1e-07 216592008768 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.1e-10 216592008769 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.2e-37 216592008770 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 216592008771 HMMPfam hit to PF05472, DNA replication terminus site-binding protei, score 7.9e-228 216592008772 fumarate hydratase; Reviewed; Region: fumC; PRK00485 216592008773 Class II fumarases; Region: Fumarase_classII; cd01362 216592008774 active site 216592008775 tetramer interface [polypeptide binding]; other site 216592008776 HMMPfam hit to PF00206, Lyase, score 1.6e-194 216592008777 PS00163 Fumarate lyases signature. 216592008778 fumarate hydratase; Provisional; Region: PRK15389 216592008779 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 216592008780 Fumarase C-terminus; Region: Fumerase_C; pfam05683 216592008781 HMMPfam hit to PF05683, Fumarase C-terminus, score 6.3e-120 216592008782 PS00163 Fumarate lyases signature. 216592008783 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 2.4e-144 216592008784 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 216592008785 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 216592008786 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 216592008787 HMMPfam hit to PF01238, Phosphomannose isomerase type I, score 2.5e-211 216592008788 PS00965 Phosphomannose isomerase type I signature 1. 216592008789 PS00966 Phosphomannose isomerase type I signature 2. 216592008790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 216592008791 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 216592008792 HMMPfam hit to PF06097, Bacterial protein of unknown function (DUF94, score 0 216592008793 Signal peptide predicted for EC042_1782 by SignalP 2.0 HMM (Signal peptide probability 0.867) with cleavage site probability 0.750 between residues 19 and 20 216592008794 1 probable transmembrane helix predicted for EC042_1782 by TMHMM2.0 at aa 5-24 216592008795 PS00017 ATP/GTP-binding site motif A (P-loop). 216592008796 putative outer membrane porin protein; Provisional; Region: PRK11379 216592008797 1 probable transmembrane helix predicted for EC042_1783 by TMHMM2.0 at aa 5-27 216592008798 Signal peptide predicted for EC042_1783 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.961 between residues 23 and 24 216592008799 glucuronide transporter; Provisional; Region: PRK09848 216592008800 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 216592008801 12 probable transmembrane helices predicted for EC042_1784 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 112-134, 147-169, 179-201, 230-252, 262-284, 297-316, 321-343, 373-392 and 407-429 216592008802 PS00527 Ribosomal protein S14 signature. 216592008803 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-11 216592008804 PS00872 Sodium:galactoside symporter family signature. 216592008805 beta-D-glucuronidase; Provisional; Region: PRK10150 216592008806 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216592008807 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216592008808 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216592008809 HMMPfam hit to PF02836, Glycosyl hydrolases family 2, TIM bar, score 4.2e-181 216592008810 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 216592008811 PS00719 Glycosyl hydrolases family 2 signature 1. 216592008812 HMMPfam hit to PF00703, Glycosyl hydrolases family 2, immunog, score 5.5e-36 216592008813 HMMPfam hit to PF02837, Glycosyl hydrolases family 2, sugar b, score 8.1e-69 216592008814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216592008815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592008816 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.3e-19 216592008817 PS01081 Bacterial regulatory proteins, tetR family signature. 216592008818 Predicted helix-turn-helix motif with score 1162.000, SD 3.14 at aa 28-49, sequence ASMKAICKSCAISPGTLYHHFI 216592008819 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 216592008820 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 216592008821 NAD binding site [chemical binding]; other site 216592008822 substrate binding site [chemical binding]; other site 216592008823 homotetramer interface [polypeptide binding]; other site 216592008824 homodimer interface [polypeptide binding]; other site 216592008825 active site 216592008826 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-100 216592008827 PS00061 Short-chain dehydrogenases/reductases family signature. 216592008828 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 216592008829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592008830 DNA binding site [nucleotide binding] 216592008831 domain linker motif; other site 216592008832 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 216592008833 putative dimerization interface [polypeptide binding]; other site 216592008834 putative ligand binding site [chemical binding]; other site 216592008835 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.8e-112 216592008836 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.2e-10 216592008837 Predicted helix-turn-helix motif with score 1696.000, SD 4.96 at aa 7-28, sequence ITIHDVALAAGVSVSTVSLVLS 216592008838 PS00356 Bacterial regulatory proteins, lacI family signature. 216592008839 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 216592008840 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 216592008841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592008842 active site turn [active] 216592008843 phosphorylation site [posttranslational modification] 216592008844 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.2e-112 216592008845 8 probable transmembrane helices predicted for EC042_1789 by TMHMM2.0 at aa 21-43, 69-88, 95-117, 139-161, 182-204, 325-347, 352-374 and 397-419 216592008846 PS00287 Cysteine proteases inhibitors signature. 216592008847 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 4.2e-19 216592008848 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592008849 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 216592008850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592008851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592008852 homodimer interface [polypeptide binding]; other site 216592008853 catalytic residue [active] 216592008854 HMMPfam hit to PF00155, Aminotransferase class I and II, score 3.5e-54 216592008855 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 216592008856 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 216592008857 active site 216592008858 purine riboside binding site [chemical binding]; other site 216592008859 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 7.4e-142 216592008860 PS00485 Adenosine and AMP deaminase signature. 216592008861 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 289-310, sequence HEYTVAAPAAGLSREQIRQAQI 216592008862 putative oxidoreductase; Provisional; Region: PRK11579 216592008863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216592008864 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216592008865 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 1e-26 216592008866 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 5.6e-43 216592008867 1 probable transmembrane helix predicted for EC042_1793 by TMHMM2.0 at aa 29-51 216592008868 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 216592008869 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 9.2e-34 216592008870 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 216592008871 Signal peptide predicted for EC042_1795 by SignalP 2.0 HMM (Signal peptide probability 0.753) with cleavage site probability 0.595 between residues 47 and 48 216592008872 4 probable transmembrane helices predicted for EC042_1795 by TMHMM2.0 at aa 21-43, 63-85, 98-117 and 122-141 216592008873 electron transport complex protein RsxA; Provisional; Region: PRK05151 216592008874 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 3.2e-116 216592008875 6 probable transmembrane helices predicted for EC042_1796 by TMHMM2.0 at aa 5-27, 37-59, 66-88, 103-125, 132-154 and 169-191 216592008876 electron transport complex protein RnfB; Provisional; Region: PRK05113 216592008877 Putative Fe-S cluster; Region: FeS; pfam04060 216592008878 4Fe-4S binding domain; Region: Fer4; pfam00037 216592008879 Signal peptide predicted for EC042_1797 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.823 between residues 30 and 31 216592008880 1 probable transmembrane helix predicted for EC042_1797 by TMHMM2.0 at aa 4-26 216592008881 HMMPfam hit to PF04060, Putative Fe-S cluster, score 1.7e-15 216592008882 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.3e-07 216592008883 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008884 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9e-06 216592008885 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008886 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 216592008887 SLBB domain; Region: SLBB; pfam10531 216592008888 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592008889 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 4.1e-106 216592008890 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0012 216592008891 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008892 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 6.9e-05 216592008893 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592008894 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 216592008895 Signal peptide predicted for EC042_1799 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.481 between residues 33 and 34 216592008896 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family, score 6.1e-208 216592008897 10 probable transmembrane helices predicted for EC042_1799 by TMHMM2.0 at aa 20-39, 43-65, 78-109, 124-143, 148-170, 214-236, 243-262, 272-294, 301-318 and 323-342 216592008898 electron transport complex protein RnfG; Validated; Region: PRK01908 216592008899 Signal peptide predicted for EC042_1800 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.960 between residues 24 and 25 216592008900 HMMPfam hit to PF04205, FMN-binding domain, score 5e-25 216592008901 electron transport complex RsxE subunit; Provisional; Region: PRK12405 216592008902 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 6.4e-122 216592008903 Signal peptide predicted for EC042_1801 by SignalP 2.0 HMM (Signal peptide probability 0.618) with cleavage site probability 0.295 between residues 38 and 39 216592008904 5 probable transmembrane helices predicted for EC042_1801 by TMHMM2.0 at aa 34-56, 69-87, 91-113, 126-148 and 183-205 216592008905 endonuclease III; Provisional; Region: PRK10702 216592008906 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216592008907 minor groove reading motif; other site 216592008908 helix-hairpin-helix signature motif; other site 216592008909 substrate binding pocket [chemical binding]; other site 216592008910 active site 216592008911 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 216592008912 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 6.6e-22 216592008913 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.9e-05 216592008914 PS01155 Endonuclease III family signature. 216592008915 PS00764 Endonuclease III iron-sulfur binding region signature. 216592008916 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 216592008917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592008918 putative substrate translocation pore; other site 216592008919 POT family; Region: PTR2; pfam00854 216592008920 14 probable transmembrane helices predicted for EC042_1803 by TMHMM2.0 at aa 22-44, 59-81, 90-107, 112-129, 150-172, 177-199, 220-239, 244-266, 275-292, 323-340, 353-375, 385-407, 419-441 and 456-478 216592008921 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.4e-15 216592008922 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 216592008923 HMMPfam hit to PF00854, POT family, score 7.9e-113 216592008924 PS00778 Histidine acid phosphatases active site signature. 216592008925 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 216592008926 glutathionine S-transferase; Provisional; Region: PRK10542 216592008927 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216592008928 C-terminal domain interface [polypeptide binding]; other site 216592008929 GSH binding site (G-site) [chemical binding]; other site 216592008930 dimer interface [polypeptide binding]; other site 216592008931 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216592008932 N-terminal domain interface [polypeptide binding]; other site 216592008933 dimer interface [polypeptide binding]; other site 216592008934 substrate binding pocket (H-site) [chemical binding]; other site 216592008935 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 4.2e-21 216592008936 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 4.9e-24 216592008937 pyridoxamine kinase; Validated; Region: PRK05756 216592008938 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 216592008939 dimer interface [polypeptide binding]; other site 216592008940 pyridoxal binding site [chemical binding]; other site 216592008941 ATP binding site [chemical binding]; other site 216592008942 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216592008943 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216592008944 active site 216592008945 HIGH motif; other site 216592008946 dimer interface [polypeptide binding]; other site 216592008947 KMSKS motif; other site 216592008948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592008949 RNA binding surface [nucleotide binding]; other site 216592008950 HMMPfam hit to PF01479, S4 domain, score 1.4e-06 216592008951 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 2e-132 216592008952 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592008953 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 216592008954 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216592008955 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 216592008956 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 216592008957 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 9e-32 216592008958 lysozyme inhibitor; Provisional; Region: PRK11372 216592008959 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 216592008960 PS00037 Myb DNA-binding domain repeat signature 1. 216592008961 Signal peptide predicted for EC042_1808 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.869 between residues 22 and 23 216592008962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592008963 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 216592008964 HMMPfam hit to PF03702, Uncharacterised protein family (UPF0075), score 3.5e-265 216592008965 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 216592008966 Signal peptide predicted for EC042_1811 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.743 between residues 21 and 22 216592008967 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592008968 transcriptional regulator SlyA; Provisional; Region: PRK03573 216592008969 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 216592008970 HMMPfam hit to PF01047, MarR family, score 2.8e-35 216592008971 PS01117 Bacterial regulatory proteins, marR family signature. 216592008972 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 47-68, sequence QSQIQLAKAIGIEQPSLVRTLD 216592008973 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 216592008974 2 probable transmembrane helices predicted for EC042_1813 by TMHMM2.0 at aa 15-40 and 53-75 216592008975 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216592008976 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592008977 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592008978 1 probable transmembrane helix predicted for EC042_1814 by TMHMM2.0 at aa 20-42 216592008979 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.7e-53 216592008980 Fusaric acid resistance protein family; Region: FUSC; pfam04632 216592008981 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592008982 12 probable transmembrane helices predicted for EC042_1815 by TMHMM2.0 at aa 23-41, 46-65, 72-90, 94-113, 120-142, 157-179, 361-380, 384-403, 410-432, 437-454, 461-483 and 493-510 216592008983 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 9.1e-50 216592008984 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 216592008985 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 216592008986 E-class dimer interface [polypeptide binding]; other site 216592008987 P-class dimer interface [polypeptide binding]; other site 216592008988 active site 216592008989 Cu2+ binding site [ion binding]; other site 216592008990 Zn2+ binding site [ion binding]; other site 216592008991 HMMPfam hit to PF00080, Copper/zinc superoxide dismutase (SODC), score 1.1e-39 216592008992 PS00332 Copper/Zinc superoxide dismutase signature 2. 216592008993 1 probable transmembrane helix predicted for EC042_1816 by TMHMM2.0 at aa 21-38 216592008994 Signal peptide predicted for EC042_1816 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.982 between residues 19 and 20 216592008995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592008996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592008997 active site 216592008998 catalytic tetrad [active] 216592008999 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1.9e-74 216592009000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216592009001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592009002 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.2e-13 216592009003 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216592009004 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216592009005 FMN binding site [chemical binding]; other site 216592009006 active site 216592009007 substrate binding site [chemical binding]; other site 216592009008 catalytic residue [active] 216592009009 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 5.9e-100 216592009010 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592009011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216592009012 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 216592009013 dimer interface [polypeptide binding]; other site 216592009014 active site 216592009015 metal binding site [ion binding]; metal-binding site 216592009016 glutathione binding site [chemical binding]; other site 216592009017 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 4.5e-43 216592009018 PS00934 Glyoxalase I signature 1. 216592009019 PS00935 Glyoxalase I signature 2. 216592009020 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 216592009021 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 216592009022 dimer interface [polypeptide binding]; other site 216592009023 catalytic site [active] 216592009024 putative active site [active] 216592009025 putative substrate binding site [chemical binding]; other site 216592009026 HMMPfam hit to PF00929, Exonuclease, score 1.5e-40 216592009027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592009028 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 216592009029 ATP binding site [chemical binding]; other site 216592009030 putative Mg++ binding site [ion binding]; other site 216592009031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592009032 nucleotide binding region [chemical binding]; other site 216592009033 ATP-binding site [chemical binding]; other site 216592009034 DEAD/H associated; Region: DEAD_assoc; pfam08494 216592009035 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.6e-42 216592009036 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009037 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592009038 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.4e-13 216592009039 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 216592009040 putative GSH binding site [chemical binding]; other site 216592009041 catalytic residues [active] 216592009042 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592009043 NlpC/P60 family; Region: NLPC_P60; pfam00877 216592009044 Signal peptide predicted for EC042_1824 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 27 and 28 216592009045 HMMPfam hit to PF00877, NlpC/P60 family, score 1e-58 216592009046 superoxide dismutase; Provisional; Region: PRK10543 216592009047 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216592009048 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216592009049 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 6.1e-53 216592009050 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009051 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 6.1e-72 216592009052 PS00088 Manganese and iron superoxide dismutases signature. 216592009053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592009055 putative substrate translocation pore; other site 216592009056 12 probable transmembrane helices predicted for EC042_1826 by TMHMM2.0 at aa 5-27, 42-64, 71-90, 100-122, 129-151, 156-178, 203-225, 235-257, 264-286, 291-308, 329-351 and 355-377 216592009057 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.8e-40 216592009058 Signal peptide predicted for EC042_1826 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.529 between residues 32 and 33 216592009059 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 216592009060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592009061 DNA binding site [nucleotide binding] 216592009062 domain linker motif; other site 216592009063 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 216592009064 dimerization interface [polypeptide binding]; other site 216592009065 ligand binding site [chemical binding]; other site 216592009066 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.1e-11 216592009067 Predicted helix-turn-helix motif with score 2035.000, SD 6.12 at aa 2-23, sequence ATIKDVAKRANVSTTTVSHVIN 216592009068 PS00356 Bacterial regulatory proteins, lacI family signature. 216592009069 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.4e-32 216592009070 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 216592009071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592009072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592009073 dimerization interface [polypeptide binding]; other site 216592009074 HMMPfam hit to PF03466, LysR substrate binding domain, score 9e-27 216592009075 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.8e-18 216592009076 PS00044 Bacterial regulatory proteins, lysR family signature. 216592009077 Predicted helix-turn-helix motif with score 1135.000, SD 3.05 at aa 17-38, sequence GSFSAAAQELHRVPSAVSYTVR 216592009078 putative transporter; Provisional; Region: PRK11043 216592009079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009080 putative substrate translocation pore; other site 216592009081 Signal peptide predicted for EC042_1829 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.901 between residues 30 and 31 216592009082 12 probable transmembrane helices predicted for EC042_1829 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 158-180, 208-230, 235-257, 270-292, 296-318, 339-357 and 361-380 216592009083 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-57 216592009084 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 216592009085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216592009086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592009087 S-adenosylmethionine binding site [chemical binding]; other site 216592009088 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid synthas, score 3e-96 216592009089 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 216592009090 Lumazine binding domain; Region: Lum_binding; pfam00677 216592009091 Lumazine binding domain; Region: Lum_binding; pfam00677 216592009092 HMMPfam hit to PF00677, Lumazine binding domain, score 2.8e-45 216592009093 PS00693 Riboflavin synthase alpha chain family signature. 216592009094 HMMPfam hit to PF00677, Lumazine binding domain, score 8.5e-45 216592009095 PS00693 Riboflavin synthase alpha chain family signature. 216592009096 multidrug efflux protein; Reviewed; Region: PRK01766 216592009097 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 216592009098 cation binding site [ion binding]; other site 216592009099 Signal peptide predicted for EC042_1832 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.395 between residues 45 and 46 216592009100 12 probable transmembrane helices predicted for EC042_1832 by TMHMM2.0 at aa 7-29, 44-66, 91-113, 128-147, 160-180, 190-212, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438 216592009101 HMMPfam hit to PF01554, MatE, score 2e-49 216592009102 HMMPfam hit to PF01554, MatE, score 2.3e-49 216592009103 hypothetical protein; Provisional; Region: PRK09945 216592009104 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592009105 putative monooxygenase; Provisional; Region: PRK11118 216592009106 hypothetical protein; Provisional; Region: PRK09897 216592009107 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216592009108 Signal peptide predicted for EC042_1836 by SignalP 2.0 HMM (Signal peptide probability 0.601) with cleavage site probability 0.276 between residues 21 and 22 216592009109 PS00215 Mitochondrial energy transfer proteins signature. 216592009110 hypothetical protein; Provisional; Region: PRK09946 216592009111 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 216592009112 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 216592009113 HMMPfam hit to PF01292, Cytochrome b561 family, score 0.00011 216592009114 5 probable transmembrane helices predicted for EC042_1838 by TMHMM2.0 at aa 28-50, 81-103, 113-135, 182-204 and 219-241 216592009115 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 216592009116 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.4e-05 216592009117 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592009118 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0054 216592009119 Signal peptide predicted for EC042_1839 by SignalP 2.0 HMM (Signal peptide probability 0.667) with cleavage site probability 0.593 between residues 44 and 45 216592009120 1 probable transmembrane helix predicted for EC042_1839 by TMHMM2.0 at aa 25-44 216592009121 hypothetical protein; Provisional; Region: PRK09947 216592009122 putative oxidoreductase; Provisional; Region: PRK09849 216592009123 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 216592009124 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 216592009125 HMMPfam hit to PF01314, Aldehyde ferredoxin oxidoreductase, domains, score 1.4e-259 216592009126 HMMPfam hit to PF02730, Aldehyde ferredoxin oxidoreductase, N-termin, score 5.8e-125 216592009127 hypothetical protein; Provisional; Region: PRK09898 216592009128 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592009129 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 9.2e-07 216592009130 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592009131 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.2e-05 216592009132 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592009133 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.004 216592009134 PS00190 Cytochrome c family heme-binding site signature. 216592009135 pyruvate kinase; Provisional; Region: PRK09206 216592009136 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 216592009137 domain interfaces; other site 216592009138 active site 216592009139 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 2.1e-209 216592009140 PS00110 Pyruvate kinase active site signature. 216592009141 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 3.8e-31 216592009142 Predicted helix-turn-helix motif with score 1022.000, SD 2.67 at aa 472-493, sequence TTNEKTAHQLVLSKGVVPQLVK 216592009143 murein lipoprotein; Provisional; Region: PRK15396 216592009144 Signal peptide predicted for EC042_1844 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.922 between residues 25 and 26 216592009145 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009146 HMMPfam hit to PF04728, Repeated sequence found in lipoprotein LPP, score 0.01 216592009147 HMMPfam hit to PF04728, Repeated sequence found in lipoprotein LPP, score 0.012 216592009148 L,D-transpeptidase; Provisional; Region: PRK10190 216592009149 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592009150 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592009151 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 3e-64 216592009152 HMMPfam hit to PF01476, LysM domain, score 7.5e-10 216592009153 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592009154 Signal peptide predicted for EC042_1845 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.927 between residues 23 and 24 216592009155 cysteine desufuration protein SufE; Provisional; Region: PRK09296 216592009156 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 1.6e-74 216592009157 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216592009158 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216592009159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592009160 catalytic residue [active] 216592009161 HMMPfam hit to PF00266, Aminotransferase class-V, score 5.7e-12 216592009162 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216592009163 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 216592009164 FeS assembly protein SufD; Region: sufD; TIGR01981 216592009165 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 2.3e-111 216592009166 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 216592009167 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 216592009168 Walker A/P-loop; other site 216592009169 ATP binding site [chemical binding]; other site 216592009170 Q-loop/lid; other site 216592009171 ABC transporter signature motif; other site 216592009172 Walker B; other site 216592009173 D-loop; other site 216592009174 H-loop/switch region; other site 216592009175 HMMPfam hit to PF00005, ABC transporter, score 2.5e-33 216592009176 PS00211 ABC transporters family signature. 216592009177 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009178 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 216592009179 putative ABC transporter; Region: ycf24; CHL00085 216592009180 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 7.2e-149 216592009181 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 216592009182 HMMPfam hit to PF01521, HesB-like domain, score 7.2e-53 216592009183 PS01152 Hypothetical hesB/yadR/yfhF family signature. 216592009184 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216592009185 CoenzymeA binding site [chemical binding]; other site 216592009186 subunit interaction site [polypeptide binding]; other site 216592009187 PHB binding site; other site 216592009188 HMMPfam hit to PF03061, Thioesterase superfamily, score 1e-17 216592009189 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216592009190 FAD binding domain; Region: FAD_binding_4; pfam01565 216592009191 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216592009192 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592009193 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 4.2e-76 216592009194 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592009195 HMMPfam hit to PF01565, FAD binding domain, score 5.6e-63 216592009196 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009197 putative inner membrane protein; Provisional; Region: PRK10983 216592009198 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216592009199 Signal peptide predicted for EC042_1855 by SignalP 2.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.880 between residues 41 and 42 216592009200 8 probable transmembrane helices predicted for EC042_1855 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 160-179, 213-235, 240-259, 266-288 and 308-330 216592009201 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 2e-78 216592009202 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 216592009203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592009205 putative substrate translocation pore; other site 216592009206 12 probable transmembrane helices predicted for EC042_1857 by TMHMM2.0 at aa 12-34, 44-66, 73-90, 95-112, 133-155, 159-181, 210-232, 242-264, 277-299, 303-325, 338-355 and 365-387 216592009207 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-30 216592009208 PS00216 Sugar transport proteins signature 1. 216592009209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009210 putative substrate translocation pore; other site 216592009211 Signal peptide predicted for EC042_1858 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.830 between residues 35 and 36 216592009212 12 probable transmembrane helices predicted for EC042_1858 by TMHMM2.0 at aa 13-35, 50-72, 77-99, 103-120, 140-162, 166-188, 214-236, 256-275, 282-301, 311-330, 342-364 and 369-391 216592009213 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.8e-31 216592009214 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 216592009215 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216592009216 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216592009217 shikimate binding site; other site 216592009218 NAD(P) binding site [chemical binding]; other site 216592009219 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 4.6e-116 216592009220 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009221 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 216592009222 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 216592009223 active site 216592009224 catalytic residue [active] 216592009225 dimer interface [polypeptide binding]; other site 216592009226 HMMPfam hit to PF01487, Type I 3-dehydroquinase, score 3e-118 216592009227 PS01028 Dehydroquinase class I active site. 216592009228 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 216592009229 Coenzyme A transferase; Region: CoA_trans; smart00882 216592009230 Coenzyme A transferase; Region: CoA_trans; cl17247 216592009231 HMMPfam hit to PF01144, Coenzyme A transferase, score 4.1e-70 216592009232 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 216592009233 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216592009234 active site 216592009235 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 9.7e-16 216592009236 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 6.3e-30 216592009237 PS00072 Acyl-CoA dehydrogenases signature 1. 216592009238 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 4e-65 216592009239 PS00073 Acyl-CoA dehydrogenases signature 2. 216592009240 Cupin domain; Region: Cupin_2; pfam07883 216592009241 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 216592009242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592009243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592009244 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 0.00049 216592009245 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 0.0058 216592009246 Predicted helix-turn-helix motif with score 1045.000, SD 2.75 at aa 197-218, sequence ITLEQLSKKFRASVSYICHEFT 216592009247 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 0.00046 216592009248 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216592009249 Ligand binding site [chemical binding]; other site 216592009250 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216592009251 HMMPfam hit to PF01012, Electron transfer flavoprotein beta subunit, score 5.3e-107 216592009252 PS01065 Electron transfer flavoprotein beta-subunit signature. 216592009253 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 216592009254 Electron transfer flavoprotein domain; Region: ETF; smart00893 216592009255 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216592009256 HMMPfam hit to PF00766, Electron transfer flavoprotein alpha subuni, score 8.1e-128 216592009257 PS00696 Electron transfer flavoprotein alpha-subunit signature. 216592009258 oxidoreductase; Provisional; Region: PRK10015 216592009259 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2e-14 216592009260 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 216592009261 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.012 216592009262 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592009263 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 216592009264 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 216592009265 acyl-activating enzyme (AAE) consensus motif; other site 216592009266 putative AMP binding site [chemical binding]; other site 216592009267 putative active site [active] 216592009268 putative CoA binding site [chemical binding]; other site 216592009269 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.5e-123 216592009270 PS00455 Putative AMP-binding domain signature. 216592009271 phosphoenolpyruvate synthase; Validated; Region: PRK06464 216592009272 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216592009273 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592009274 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216592009275 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 4.1e-58 216592009276 PS00742 PEP-utilizing enzymes signature 2. 216592009277 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 5.5e-45 216592009278 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216592009279 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyru, score 6.3e-175 216592009280 PEP synthetase regulatory protein; Provisional; Region: PRK05339 216592009281 HMMPfam hit to PF03618, Domain of unknown function (DUF299), score 2.8e-167 216592009282 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009283 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 216592009284 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216592009285 HMMPfam hit to PF00793, DAHP synthetase I family, score 2.8e-178 216592009286 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 216592009287 Uncharacterized conserved protein [Function unknown]; Region: COG0397 216592009288 hypothetical protein; Validated; Region: PRK00029 216592009289 HMMPfam hit to PF02696, Uncharacterized ACR, YdiU/UPF0061 family, score 0 216592009290 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 216592009291 NlpC/P60 family; Region: NLPC_P60; pfam00877 216592009292 HMMPfam hit to PF00877, NlpC/P60 family, score 4.3e-51 216592009293 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009294 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 216592009295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592009296 Walker A/P-loop; other site 216592009297 ATP binding site [chemical binding]; other site 216592009298 Q-loop/lid; other site 216592009299 ABC transporter signature motif; other site 216592009300 Walker B; other site 216592009301 D-loop; other site 216592009302 H-loop/switch region; other site 216592009303 HMMPfam hit to PF00005, ABC transporter, score 4.4e-36 216592009304 PS00211 ABC transporters family signature. 216592009305 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009306 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 216592009307 catalytic residues [active] 216592009308 dimer interface [polypeptide binding]; other site 216592009309 HMMPfam hit to PF00255, Glutathione peroxidase, score 2e-75 216592009310 PS00763 Glutathione peroxidases signature 2. 216592009311 PS00460 Glutathione peroxidases selenocysteine active site. 216592009312 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592009313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592009314 ABC-ATPase subunit interface; other site 216592009315 dimer interface [polypeptide binding]; other site 216592009316 putative PBP binding regions; other site 216592009317 HMMPfam hit to PF01032, FecCD transport family, score 8.7e-129 216592009318 9 probable transmembrane helices predicted for EC042_1878 by TMHMM2.0 at aa 13-35, 55-77, 90-107, 111-133, 146-168, 188-205, 242-264, 274-296 and 303-322 216592009319 Signal peptide predicted for EC042_1878 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.726 between residues 33 and 34 216592009320 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216592009321 IHF dimer interface [polypeptide binding]; other site 216592009322 IHF - DNA interface [nucleotide binding]; other site 216592009323 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 6.2e-47 216592009324 PS00045 Bacterial histone-like DNA-binding proteins signature. 216592009325 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 216592009326 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 216592009327 putative tRNA-binding site [nucleotide binding]; other site 216592009328 B3/4 domain; Region: B3_4; pfam03483 216592009329 tRNA synthetase B5 domain; Region: B5; smart00874 216592009330 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 216592009331 dimer interface [polypeptide binding]; other site 216592009332 motif 1; other site 216592009333 motif 3; other site 216592009334 motif 2; other site 216592009335 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 216592009336 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 1.2e-47 216592009337 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592009338 HMMPfam hit to PF03484, tRNA synthetase B5 domain, score 3.4e-32 216592009339 HMMPfam hit to PF03483, B3/4 domain, score 5.7e-114 216592009340 HMMPfam hit to PF01588, Putative tRNA binding domain, score 2e-42 216592009341 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 216592009342 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 216592009343 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 216592009344 dimer interface [polypeptide binding]; other site 216592009345 motif 1; other site 216592009346 active site 216592009347 motif 2; other site 216592009348 motif 3; other site 216592009349 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 2.2e-140 216592009350 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592009351 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592009352 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 1.7e-39 216592009353 Signal peptide predicted for EC042_1881 by SignalP 2.0 HMM (Signal peptide probability 0.736) with cleavage site probability 0.655 between residues 22 and 23 216592009354 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 216592009355 23S rRNA binding site [nucleotide binding]; other site 216592009356 L21 binding site [polypeptide binding]; other site 216592009357 L13 binding site [polypeptide binding]; other site 216592009358 HMMPfam hit to PF00453, Ribosomal protein L20, score 2.6e-69 216592009359 PS00937 Ribosomal protein L20 signature. 216592009360 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 216592009361 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.1e-32 216592009362 PS00936 Ribosomal protein L35 signature. 216592009363 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 216592009364 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 216592009365 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 216592009366 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 2.5e-55 216592009367 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 8.5e-20 216592009368 PS00938 Initiation factor 3 signature. 216592009369 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 216592009370 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 216592009371 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 216592009372 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 216592009373 active site 216592009374 dimer interface [polypeptide binding]; other site 216592009375 motif 1; other site 216592009376 motif 2; other site 216592009377 motif 3; other site 216592009378 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 216592009379 anticodon binding site; other site 216592009380 HMMPfam hit to PF03129, Anticodon binding domain, score 4.6e-34 216592009381 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592009382 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1e-56 216592009383 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592009384 HMMPfam hit to PF02824, TGS domain, score 8.4e-15 216592009385 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 216592009386 PS00447 DNA polymerase family A signature. 216592009387 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 216592009388 HMMPfam hit to PF04338, Protein of unknown function, DUF481, score 1.9e-128 216592009389 Signal peptide predicted for EC042_1887 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.936 between residues 25 and 26 216592009390 6-phosphofructokinase 2; Provisional; Region: PRK10294 216592009391 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 216592009392 putative substrate binding site [chemical binding]; other site 216592009393 putative ATP binding site [chemical binding]; other site 216592009394 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.7e-68 216592009395 PS00583 pfkB family of carbohydrate kinases signature 1. 216592009396 PS00584 pfkB family of carbohydrate kinases signature 2. 216592009397 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 216592009398 Phosphotransferase enzyme family; Region: APH; pfam01636 216592009399 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216592009400 active site 216592009401 ATP binding site [chemical binding]; other site 216592009402 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216592009403 HMMPfam hit to PF03881, Fructosamine kinase, score 5.2e-226 216592009404 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 1.4e-35 216592009405 YniB-like protein; Region: YniB; pfam14002 216592009406 3 probable transmembrane helices predicted for EC042_1891 by TMHMM2.0 at aa 15-33, 79-101 and 155-177 216592009407 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 216592009408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216592009409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592009410 motif II; other site 216592009411 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.1e-31 216592009412 inner membrane protein; Provisional; Region: PRK11648 216592009413 HMMPfam hit to PF04307, Predicted membrane-bound metal-dependent hyd, score 1.5e-41 216592009414 2 probable transmembrane helices predicted for EC042_1893 by TMHMM2.0 at aa 72-94 and 109-131 216592009415 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 216592009416 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216592009417 Signal peptide predicted for EC042_1894 by SignalP 2.0 HMM (Signal peptide probability 0.944) with cleavage site probability 0.722 between residues 20 and 21 216592009418 9 probable transmembrane helices predicted for EC042_1894 by TMHMM2.0 at aa 5-20, 33-51, 71-93, 105-127, 180-202, 260-282, 340-362, 369-391 and 395-417 216592009419 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.1e-113 216592009420 cell division modulator; Provisional; Region: PRK10113 216592009421 hydroperoxidase II; Provisional; Region: katE; PRK11249 216592009422 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 216592009423 tetramer interface [polypeptide binding]; other site 216592009424 heme binding pocket [chemical binding]; other site 216592009425 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 216592009426 domain interactions; other site 216592009427 HMMPfam hit to PF00199, Catalase, score 2e-283 216592009428 PS00438 Catalase proximal active site signature. 216592009429 PS00437 Catalase proximal heme-ligand signature. 216592009430 HMMPfam hit to PF06628, Catalase-related, score 9.3e-31 216592009431 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 216592009432 putative active site [active] 216592009433 YdjC motif; other site 216592009434 Mg binding site [ion binding]; other site 216592009435 putative homodimer interface [polypeptide binding]; other site 216592009436 HMMPfam hit to PF04794, YdjC-like protein, score 3.6e-131 216592009437 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 216592009438 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 216592009439 NAD binding site [chemical binding]; other site 216592009440 sugar binding site [chemical binding]; other site 216592009441 divalent metal binding site [ion binding]; other site 216592009442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592009443 dimer interface [polypeptide binding]; other site 216592009444 HMMPfam hit to PF02056, Family 4 glycosyl hydrolase, score 1.3e-234 216592009445 PS01324 Glycosyl hydrolases family 4 signature. 216592009446 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 216592009447 Cupin domain; Region: Cupin_2; pfam07883 216592009448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592009449 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-13 216592009450 PS00041 Bacterial regulatory proteins, araC family signature. 216592009451 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.091 216592009452 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 216592009453 methionine cluster; other site 216592009454 active site 216592009455 phosphorylation site [posttranslational modification] 216592009456 metal binding site [ion binding]; metal-binding site 216592009457 HMMPfam hit to PF02255, PTS system, Lactose/Cellobiose specific IIA, score 1.2e-53 216592009458 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 216592009459 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 216592009460 10 probable transmembrane helices predicted for EC042_1902 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 186-208, 232-254, 298-320, 345-364, 371-393 and 408-430 216592009461 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9.9e-91 216592009462 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009463 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 216592009464 active site 216592009465 P-loop; other site 216592009466 phosphorylation site [posttranslational modification] 216592009467 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 2.6e-31 216592009468 Signal peptide predicted for EC042_1903 by SignalP 2.0 HMM (Signal peptide probability 0.690) with cleavage site probability 0.227 between residues 27 and 28 216592009469 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 216592009470 HMMPfam hit to PF04355, SmpA / OmlA family, score 2.8e-22 216592009471 Predicted helix-turn-helix motif with score 1020.000, SD 2.66 at aa 43-64, sequence MSRAQVAQIAGKPSSEVSMIHA 216592009472 1 probable transmembrane helix predicted for EC042_1904 by TMHMM2.0 at aa 5-24 216592009473 Signal peptide predicted for EC042_1904 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 23 and 24 216592009474 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009475 NAD+ synthetase; Region: nadE; TIGR00552 216592009476 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 216592009477 homodimer interface [polypeptide binding]; other site 216592009478 NAD binding pocket [chemical binding]; other site 216592009479 ATP binding pocket [chemical binding]; other site 216592009480 Mg binding site [ion binding]; other site 216592009481 active-site loop [active] 216592009482 HMMPfam hit to PF02540, NAD synthase, score 9.7e-82 216592009483 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 216592009484 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216592009485 GIY-YIG motif/motif A; other site 216592009486 active site 216592009487 catalytic site [active] 216592009488 putative DNA binding site [nucleotide binding]; other site 216592009489 metal binding site [ion binding]; metal-binding site 216592009490 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 1.8e-16 216592009491 hypothetical protein; Provisional; Region: PRK11396 216592009492 HMMPfam hit to PF05962, Bacterial protein of unknown function (DUF88, score 1.3e-95 216592009493 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 216592009494 dimer interface [polypeptide binding]; other site 216592009495 Signal peptide predicted for EC042_1908 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 216592009496 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 216592009497 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 216592009498 putative active site [active] 216592009499 Zn binding site [ion binding]; other site 216592009500 HMMPfam hit to PF04952, Succinylglutamate desuccinylase / Aspartoac, score 4.2e-97 216592009501 succinylarginine dihydrolase; Provisional; Region: PRK13281 216592009502 HMMPfam hit to PF04996, Succinylarginine dihydrolase, score 0 216592009503 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 216592009504 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 216592009505 NAD(P) binding site [chemical binding]; other site 216592009506 catalytic residues [active] 216592009507 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.8e-73 216592009508 PS00070 Aldehyde dehydrogenases cysteine active site. 216592009509 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592009510 arginine succinyltransferase; Provisional; Region: PRK10456 216592009511 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 216592009512 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 3.2e-256 216592009513 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 216592009514 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592009515 inhibitor-cofactor binding pocket; inhibition site 216592009516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592009517 catalytic residue [active] 216592009518 HMMPfam hit to PF00202, Aminotransferase class-III, score 3.8e-166 216592009519 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592009520 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216592009521 putative catalytic site [active] 216592009522 putative phosphate binding site [ion binding]; other site 216592009523 active site 216592009524 metal binding site A [ion binding]; metal-binding site 216592009525 DNA binding site [nucleotide binding] 216592009526 putative AP binding site [nucleotide binding]; other site 216592009527 putative metal binding site B [ion binding]; other site 216592009528 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 2e-52 216592009529 PS00726 AP endonucleases family 1 signature 1. 216592009530 PS00728 AP endonucleases family 1 signature 3. 216592009531 Uncharacterized conserved protein [Function unknown]; Region: COG0398 216592009532 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216592009533 5 probable transmembrane helices predicted for EC042_1915 by TMHMM2.0 at aa 24-46, 66-88, 95-117, 174-196 and 203-225 216592009534 HMMPfam hit to PF00597, DedA family, score 2e-06 216592009535 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009536 Uncharacterized conserved protein [Function unknown]; Region: COG0398 216592009537 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216592009538 Signal peptide predicted for EC042_1917 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.713 between residues 45 and 46 216592009539 5 probable transmembrane helices predicted for EC042_1917 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 174-196 and 201-223 216592009540 HMMPfam hit to PF00597, DedA family, score 9.6e-06 216592009541 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216592009542 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216592009543 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 0.00019 216592009544 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 216592009545 hypothetical protein; Provisional; Region: PRK11622 216592009546 Signal peptide predicted for EC042_1919 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592009547 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 216592009548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592009549 dimer interface [polypeptide binding]; other site 216592009550 conserved gate region; other site 216592009551 putative PBP binding loops; other site 216592009552 ABC-ATPase subunit interface; other site 216592009553 Signal peptide predicted for EC042_1920 by SignalP 2.0 HMM (Signal peptide probability 0.779) with cleavage site probability 0.184 between residues 27 and 28 216592009554 12 probable transmembrane helices predicted for EC042_1920 by TMHMM2.0 at aa 7-29, 58-80, 92-114, 134-156, 177-199, 238-260, 283-305, 315-337, 346-368, 378-400, 421-443 and 483-505 216592009555 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592009556 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 216592009557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592009558 Walker A/P-loop; other site 216592009559 ATP binding site [chemical binding]; other site 216592009560 Q-loop/lid; other site 216592009561 ABC transporter signature motif; other site 216592009562 Walker B; other site 216592009563 D-loop; other site 216592009564 H-loop/switch region; other site 216592009565 HMMPfam hit to PF00005, ABC transporter, score 7.5e-36 216592009566 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009567 PS00211 ABC transporters family signature. 216592009568 Rhodanese Homology Domain; Region: RHOD; smart00450 216592009569 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216592009570 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216592009571 active site residue [active] 216592009572 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216592009573 active site residue [active] 216592009574 Signal peptide predicted for EC042_1922 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 28 and 29 216592009575 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009576 PS00380 Rhodanese signature 1. 216592009577 PS00683 Rhodanese C-terminal signature. 216592009578 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216592009579 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 8.8e-21 216592009580 5 probable transmembrane helices predicted for EC042_1923 by TMHMM2.0 at aa 40-62, 82-104, 114-136, 149-168 and 178-200 216592009581 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216592009582 active site 216592009583 8-oxo-dGMP binding site [chemical binding]; other site 216592009584 nudix motif; other site 216592009585 metal binding site [ion binding]; metal-binding site 216592009586 HMMPfam hit to PF00293, NUDIX domain, score 3.6e-30 216592009587 PS00893 mutT domain signature. 216592009588 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 216592009589 HMMPfam hit to PF07383, Protein of unknown function (DUF1496), score 8.2e-64 216592009590 Signal peptide predicted for EC042_1925 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.966 between residues 18 and 19 216592009591 glutamate dehydrogenase; Provisional; Region: PRK09414 216592009592 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216592009593 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 216592009594 NAD(P) binding site [chemical binding]; other site 216592009595 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 8.8e-86 216592009596 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 216592009597 HMMPfam hit to PF00208, Glutamate/Leucine/Phenylalanine/Valin, score 6.4e-133 216592009598 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216592009599 HSP70 interaction site [polypeptide binding]; other site 216592009600 Sel1-like repeats; Region: SEL1; smart00671 216592009601 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216592009602 Sel1-like repeats; Region: SEL1; smart00671 216592009603 Sel1-like repeats; Region: SEL1; smart00671 216592009604 Sel1-like repeats; Region: SEL1; smart00671 216592009605 Sel1-like repeats; Region: SEL1; smart00671 216592009606 HMMPfam hit to PF00226, DnaJ domain, score 0.00052 216592009607 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 216592009608 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 216592009609 nucleotide binding site [chemical binding]; other site 216592009610 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216592009611 SBD interface [polypeptide binding]; other site 216592009612 HMMPfam hit to PF00012, Hsp70 protein, score 1.8e-132 216592009613 PS01036 Heat shock hsp70 proteins family signature 3. 216592009614 PS00329 Heat shock hsp70 proteins family signature 2. 216592009615 PS00297 Heat shock hsp70 proteins family signature 1. 216592009616 DNA topoisomerase III; Provisional; Region: PRK07726 216592009617 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 216592009618 active site 216592009619 putative interdomain interaction site [polypeptide binding]; other site 216592009620 putative metal-binding site [ion binding]; other site 216592009621 putative nucleotide binding site [chemical binding]; other site 216592009622 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 216592009623 domain I; other site 216592009624 DNA binding groove [nucleotide binding] 216592009625 phosphate binding site [ion binding]; other site 216592009626 domain II; other site 216592009627 domain III; other site 216592009628 nucleotide binding site [chemical binding]; other site 216592009629 catalytic site [active] 216592009630 domain IV; other site 216592009631 HMMPfam hit to PF01131, DNA topoisomerase, score 3e-191 216592009632 PS00396 Prokaryotic DNA topoisomerase I active site. 216592009633 HMMPfam hit to PF01751, Toprim domain, score 2.7e-37 216592009634 selenophosphate synthetase; Provisional; Region: PRK00943 216592009635 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 216592009636 dimerization interface [polypeptide binding]; other site 216592009637 putative ATP binding site [chemical binding]; other site 216592009638 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.3e-25 216592009639 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 1.9e-24 216592009640 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 216592009641 putative FMN binding site [chemical binding]; other site 216592009642 HMMPfam hit to PF00881, Nitroreductase family, score 1.7e-51 216592009643 protease 4; Provisional; Region: PRK10949 216592009644 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 216592009645 tandem repeat interface [polypeptide binding]; other site 216592009646 oligomer interface [polypeptide binding]; other site 216592009647 active site residues [active] 216592009648 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 216592009649 tandem repeat interface [polypeptide binding]; other site 216592009650 oligomer interface [polypeptide binding]; other site 216592009651 active site residues [active] 216592009652 1 probable transmembrane helix predicted for EC042_1932 by TMHMM2.0 at aa 30-52 216592009653 HMMPfam hit to PF01343, Peptidase family S49, score 9.9e-66 216592009654 HMMPfam hit to PF01343, Peptidase family S49, score 1.4e-78 216592009655 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 216592009656 active site 216592009657 homodimer interface [polypeptide binding]; other site 216592009658 PS00144 Asparaginase / glutaminase active site signature 1. 216592009659 HMMPfam hit to PF00710, Asparaginase, score 1.6e-149 216592009660 PS00917 Asparaginase / glutaminase active site signature 2. 216592009661 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 216592009662 Isochorismatase family; Region: Isochorismatase; pfam00857 216592009663 catalytic triad [active] 216592009664 metal binding site [ion binding]; metal-binding site 216592009665 conserved cis-peptide bond; other site 216592009666 HMMPfam hit to PF00857, Isochorismatase family, score 2.6e-100 216592009667 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 216592009668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009669 putative substrate translocation pore; other site 216592009670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009671 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.5e-24 216592009672 12 probable transmembrane helices predicted for EC042_1935 by TMHMM2.0 at aa 21-43, 58-80, 92-114, 118-140, 153-175, 179-198, 266-288, 298-320, 327-344, 354-376, 389-411 and 416-438 216592009673 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.8e-31 216592009674 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216592009675 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216592009676 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592009677 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.4e-69 216592009678 PS00894 Bacterial regulatory proteins, deoR family signature. 216592009679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592009680 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592009681 active site 216592009682 catalytic tetrad [active] 216592009683 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1.9e-41 216592009684 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592009685 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216592009686 substrate binding site [chemical binding]; other site 216592009687 ATP binding site [chemical binding]; other site 216592009688 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.5e-79 216592009689 PS00584 pfkB family of carbohydrate kinases signature 2. 216592009690 PS00583 pfkB family of carbohydrate kinases signature 1. 216592009691 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 216592009692 intersubunit interface [polypeptide binding]; other site 216592009693 active site 216592009694 zinc binding site [ion binding]; other site 216592009695 Na+ binding site [ion binding]; other site 216592009696 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 4.1e-65 216592009697 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592009698 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 216592009699 inhibitor binding site; inhibition site 216592009700 catalytic Zn binding site [ion binding]; other site 216592009701 structural Zn binding site [ion binding]; other site 216592009702 NADP binding site [chemical binding]; other site 216592009703 tetramer interface [polypeptide binding]; other site 216592009704 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.4e-96 216592009705 PS00693 Riboflavin synthase alpha chain family signature. 216592009706 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592009707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009709 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.3e-19 216592009710 12 probable transmembrane helices predicted for EC042_1941 by TMHMM2.0 at aa 27-49, 59-81, 90-109, 114-136, 148-170, 180-202, 266-288, 301-323, 330-352, 356-378, 391-413 and 418-440 216592009711 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-26 216592009712 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592009713 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 216592009714 putative NAD(P) binding site [chemical binding]; other site 216592009715 catalytic Zn binding site [ion binding]; other site 216592009716 structural Zn binding site [ion binding]; other site 216592009717 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 9.4e-87 216592009718 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 216592009720 HMMPfam hit to PF07023, Protein of unknown function (DUF1315), score 1.5e-64 216592009721 methionine sulfoxide reductase B; Provisional; Region: PRK00222 216592009722 SelR domain; Region: SelR; pfam01641 216592009723 HMMPfam hit to PF01641, SelR domain, score 3.6e-91 216592009724 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 216592009725 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 216592009726 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216592009727 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 3.8e-97 216592009728 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216592009729 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 2.8e-126 216592009730 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 216592009731 active site 216592009732 phosphate binding residues; other site 216592009733 catalytic residues [active] 216592009734 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.1e-50 216592009735 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009736 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592009737 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592009738 active site 216592009739 catalytic tetrad [active] 216592009740 HMMPfam hit to PF00248, Aldo/keto reductase family, score 7.4e-67 216592009741 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 216592009742 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 3.2e-106 216592009743 Signal peptide predicted for EC042_1948 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 22 and 23 216592009744 PrkA family serine protein kinase; Provisional; Region: PRK15455 216592009745 AAA ATPase domain; Region: AAA_16; pfam13191 216592009746 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 216592009747 HMMPfam hit to PF06798, PrkA serine protein kinase, score 0 216592009748 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009749 hypothetical protein; Provisional; Region: PRK05325 216592009750 HMMPfam hit to PF04285, Protein of unknown function (DUF444), score 1.8e-289 216592009751 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592009752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592009753 metal binding site [ion binding]; metal-binding site 216592009754 active site 216592009755 I-site; other site 216592009756 8 probable transmembrane helices predicted for EC042_1951 by TMHMM2.0 at aa 55-77, 87-109, 121-143, 163-182, 195-214, 234-256, 263-285 and 295-317 216592009757 HMMPfam hit to PF00990, GGDEF domain, score 2e-58 216592009758 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592009759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592009760 metal binding site [ion binding]; metal-binding site 216592009761 active site 216592009762 I-site; other site 216592009763 2 probable transmembrane helices predicted for EC042_1952 by TMHMM2.0 at aa 71-90 and 365-387 216592009764 HMMPfam hit to PF00990, GGDEF domain, score 4e-52 216592009765 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 216592009766 putative deacylase active site [active] 216592009767 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 2.8e-51 216592009768 Predicted membrane protein [Function unknown]; Region: COG2707 216592009769 HMMPfam hit to PF04284, Protein of unknown function (DUF441), score 1.3e-85 216592009770 Signal peptide predicted for EC042_1955 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.585 between residues 24 and 25 216592009771 4 probable transmembrane helices predicted for EC042_1955 by TMHMM2.0 at aa 12-34, 49-71, 78-100 and 124-146 216592009772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592009773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592009774 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00054 216592009775 PS00041 Bacterial regulatory proteins, araC family signature. 216592009776 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.5 216592009777 cyanate transporter; Region: CynX; TIGR00896 216592009778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009779 Signal peptide predicted for EC042_1957 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.753 between residues 33 and 34 216592009780 12 probable transmembrane helices predicted for EC042_1957 by TMHMM2.0 at aa 13-31, 46-68, 81-98, 103-125, 137-159, 163-185, 217-239, 249-271, 278-300, 304-326, 333-355 and 365-387 216592009781 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.6e-23 216592009782 Uncharacterized conserved protein [Function unknown]; Region: COG3189 216592009783 HMMPfam hit to PF04343, Protein of unknown function, DUF488, score 5.9e-43 216592009784 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 216592009785 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 216592009786 Domain of unknown function (DUF333); Region: DUF333; pfam03891 216592009787 HMMPfam hit to PF03891, Domain of unknown function (DUF333), score 2.4e-45 216592009788 Signal peptide predicted for EC042_1959 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.418 between residues 21 and 22 216592009789 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009790 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216592009791 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592009792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592009793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592009794 metal binding site [ion binding]; metal-binding site 216592009795 active site 216592009796 I-site; other site 216592009797 HMMPfam hit to PF01590, GAF domain, score 8.8e-11 216592009798 HMMPfam hit to PF00990, GGDEF domain, score 8.9e-55 216592009799 hypothetical protein; Provisional; Region: PRK10457 216592009800 HMMPfam hit to PF04226, Transglycosylase associated protein, score 4.5e-21 216592009801 3 probable transmembrane helices predicted for EC042_1961 by TMHMM2.0 at aa 4-21, 28-50 and 60-77 216592009802 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 216592009803 leucine export protein LeuE; Provisional; Region: PRK10958 216592009804 HMMPfam hit to PF01810, LysE type translocator, score 2.5e-71 216592009805 6 probable transmembrane helices predicted for EC042_1963 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 191-210 216592009806 Present in 0157, absent in Uropathogenic, misc utilization operon (regulator, tartrate dehydrogenase/decarboxylase, putative betaine/choline/glycine transport protein and misc. dioxygenase) 216592009807 transcriptional activator TtdR; Provisional; Region: PRK09801 216592009808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592009809 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 216592009810 putative effector binding pocket; other site 216592009811 putative dimerization interface [polypeptide binding]; other site 216592009812 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-40 216592009813 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-16 216592009814 PS00044 Bacterial regulatory proteins, lysR family signature. 216592009815 Predicted helix-turn-helix motif with score 1466.000, SD 4.18 at aa 27-48, sequence AGFAAVAEELGVSPAFVSKRIA 216592009816 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 216592009817 tartrate dehydrogenase; Region: TTC; TIGR02089 216592009818 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 1.6e-96 216592009819 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216592009820 putative transporter; Provisional; Region: PRK09950 216592009821 Signal peptide predicted for EC042_1966 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.476 between residues 37 and 38 216592009822 HMMPfam hit to PF02028, BCCT family transporter, score 3e-67 216592009823 12 probable transmembrane helices predicted for EC042_1966 by TMHMM2.0 at aa 12-29, 44-66, 86-108, 137-159, 191-213, 226-248, 261-283, 313-332, 344-363, 403-425, 445-464 and 474-496 216592009824 PS01303 BCCT family of transporters signature. 216592009825 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216592009826 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216592009827 [2Fe-2S] cluster binding site [ion binding]; other site 216592009828 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 216592009829 putative alpha subunit interface [polypeptide binding]; other site 216592009830 putative active site [active] 216592009831 putative substrate binding site [chemical binding]; other site 216592009832 Fe binding site [ion binding]; other site 216592009833 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 1.6e-27 216592009834 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216592009835 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 216592009836 FMN-binding pocket [chemical binding]; other site 216592009837 flavin binding motif; other site 216592009838 phosphate binding motif [ion binding]; other site 216592009839 beta-alpha-beta structure motif; other site 216592009840 NAD binding pocket [chemical binding]; other site 216592009841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592009842 catalytic loop [active] 216592009843 iron binding site [ion binding]; other site 216592009844 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 1.6e-07 216592009845 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.2e-05 216592009846 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 2.2e-16 216592009847 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216592009848 ribonuclease D; Provisional; Region: PRK10829 216592009849 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 216592009850 catalytic site [active] 216592009851 putative active site [active] 216592009852 putative substrate binding site [chemical binding]; other site 216592009853 Helicase and RNase D C-terminal; Region: HRDC; smart00341 216592009854 HMMPfam hit to PF00570, HRDC domain, score 2.1e-27 216592009855 HMMPfam hit to PF01612, 3'-5' exonuclease, score 5.3e-72 216592009856 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 216592009857 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 216592009858 acyl-activating enzyme (AAE) consensus motif; other site 216592009859 putative AMP binding site [chemical binding]; other site 216592009860 putative active site [active] 216592009861 putative CoA binding site [chemical binding]; other site 216592009862 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.8e-137 216592009863 PS00455 Putative AMP-binding domain signature. 216592009864 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592009865 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 216592009866 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 1.1e-101 216592009867 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592009868 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 216592009869 Glycoprotease family; Region: Peptidase_M22; pfam00814 216592009870 HMMPfam hit to PF00814, Glycoprotease family, score 3.5e-19 216592009871 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 216592009872 DEAD/DEAH box helicase; Region: DEAD; pfam00270 216592009873 DEAD_2; Region: DEAD_2; pfam06733 216592009874 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 216592009875 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009876 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216592009877 homotrimer interaction site [polypeptide binding]; other site 216592009878 putative active site [active] 216592009879 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 4.5e-40 216592009880 PS01094 Uncharacterized protein family UPF0076 signature. 216592009881 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 216592009882 hypothetical protein; Provisional; Region: PRK05114 216592009883 HMMPfam hit to PF03701, Uncharacterised protein family (UPF0181), score 4.3e-36 216592009884 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 216592009885 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216592009886 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 216592009887 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 2.3e-48 216592009888 HMMPfam hit to PF00425, chorismate binding enzyme, score 1.1e-150 216592009889 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216592009890 putative active site [active] 216592009891 putative CoA binding site [chemical binding]; other site 216592009892 nudix motif; other site 216592009893 metal binding site [ion binding]; metal-binding site 216592009894 HMMPfam hit to PF00293, NUDIX domain, score 7.1e-18 216592009895 PS01293 Uncharacterized protein family UPF0035 signature. 216592009896 L-serine deaminase; Provisional; Region: PRK15023 216592009897 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216592009898 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216592009899 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 6.1e-109 216592009900 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.2e-208 216592009901 phage resistance protein; Provisional; Region: PRK10551 216592009902 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216592009903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592009904 Signal peptide predicted for EC042_1980 by SignalP 2.0 HMM (Signal peptide probability 0.968) with cleavage site probability 0.698 between residues 38 and 39 216592009905 1 probable transmembrane helix predicted for EC042_1980 by TMHMM2.0 at aa 21-43 216592009906 HMMPfam hit to PF00563, EAL domain, score 5.4e-106 216592009907 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 216592009908 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216592009909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216592009910 Transporter associated domain; Region: CorC_HlyC; smart01091 216592009911 HMMPfam hit to PF03471, Transporter associated domain, score 3.2e-21 216592009912 HMMPfam hit to PF00571, CBS domain, score 0.00036 216592009913 HMMPfam hit to PF00571, CBS domain, score 1.5e-06 216592009914 7 probable transmembrane helices predicted for EC042_1981 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 150-172, 185-207 and 212-231 216592009915 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 6.7e-78 216592009916 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 216592009917 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 216592009918 active pocket/dimerization site; other site 216592009919 active site 216592009920 phosphorylation site [posttranslational modification] 216592009921 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 216592009922 active site 216592009923 phosphorylation site [posttranslational modification] 216592009924 HMMPfam hit to PF03610, PTS system fructose IIA component, score 2.2e-52 216592009925 HMMPfam hit to PF03830, PTS system sorbose subfamily IIB componen, score 1.3e-99 216592009926 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 216592009927 HMMPfam hit to PF03609, PTS system sorbose-specific iic component, score 2e-148 216592009928 7 probable transmembrane helices predicted for EC042_1983 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 137-159, 180-202 and 217-239 216592009929 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 216592009930 HMMPfam hit to PF03613, PTS system mannose/fructose/sorbose family I, score 6.7e-190 216592009931 2 probable transmembrane helices predicted for EC042_1984 by TMHMM2.0 at aa 135-157 and 262-284 216592009932 Predicted membrane protein [Function unknown]; Region: COG4811 216592009933 Signal peptide predicted for EC042_1985 by SignalP 2.0 HMM (Signal peptide probability 0.894) with cleavage site probability 0.798 between residues 19 and 20 216592009934 HMMPfam hit to PF06173, Protein of unknown function (DUF986), score 9e-111 216592009935 2 probable transmembrane helices predicted for EC042_1985 by TMHMM2.0 at aa 7-26 and 65-87 216592009936 hypothetical protein; Provisional; Region: PRK11469 216592009937 Domain of unknown function DUF; Region: DUF204; pfam02659 216592009938 Domain of unknown function DUF; Region: DUF204; pfam02659 216592009939 6 probable transmembrane helices predicted for EC042_1986 by TMHMM2.0 at aa 20-42, 55-77, 82-104, 124-146, 151-173 and 186-205 216592009940 HMMPfam hit to PF02659, Domain of unknown function DUF, score 4.5e-42 216592009941 HMMPfam hit to PF02659, Domain of unknown function DUF, score 5.7e-35 216592009942 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 216592009943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592009944 S-adenosylmethionine binding site [chemical binding]; other site 216592009945 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592009946 DNA-binding site [nucleotide binding]; DNA binding site 216592009947 RNA-binding motif; other site 216592009948 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.9e-43 216592009949 PS00352 'Cold-shock' DNA-binding domain signature. 216592009951 YebO-like protein; Region: YebO; pfam13974 216592009952 1 probable transmembrane helix predicted for EC042_1990 by TMHMM2.0 at aa 10-32 216592009953 YobH-like protein; Region: YobH; pfam13996 216592009954 Signal peptide predicted for EC042_1991 by SignalP 2.0 HMM (Signal peptide probability 0.954) with cleavage site probability 0.725 between residues 33 and 34 216592009955 1 probable transmembrane helix predicted for EC042_1991 by TMHMM2.0 at aa 7-29 216592009956 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 216592009957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592009958 dimerization interface [polypeptide binding]; other site 216592009959 putative Zn2+ binding site [ion binding]; other site 216592009960 putative DNA binding site [nucleotide binding]; other site 216592009961 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592009962 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 3.6e-98 216592009963 PS01051 Bacterial regulatory proteins, iclR family signature. 216592009964 Predicted helix-turn-helix motif with score 1951.000, SD 5.83 at aa 32-53, sequence IGITELSQRVMMSKSTVYRFLQ 216592009965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592009966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592009967 putative substrate translocation pore; other site 216592009968 12 probable transmembrane helices predicted for EC042_1993 by TMHMM2.0 at aa 52-74, 89-111, 124-146, 150-169, 181-203, 208-230, 242-264, 268-286, 306-328, 343-365, 372-394 and 463-485 216592009969 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.3e-57 216592009970 heat shock protein HtpX; Provisional; Region: PRK05457 216592009971 HMMPfam hit to PF01435, Peptidase family M48, score 6.3e-44 216592009972 PS00017 ATP/GTP-binding site motif A (P-loop). 216592009973 4 probable transmembrane helices predicted for EC042_1994 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 216592009974 HMMPfam hit to PF06509, HtpX N-terminus, score 1.5e-54 216592009975 Signal peptide predicted for EC042_1994 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.472 between residues 63 and 64 216592009976 carboxy-terminal protease; Provisional; Region: PRK11186 216592009977 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216592009978 protein binding site [polypeptide binding]; other site 216592009979 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216592009980 Catalytic dyad [active] 216592009981 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 216592009982 HMMPfam hit to PF03572, Peptidase family S41, score 3e-68 216592009983 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.2e-16 216592009984 1 probable transmembrane helix predicted for EC042_1995 by TMHMM2.0 at aa 20-39 216592009985 ProP expression regulator; Provisional; Region: PRK04950 216592009986 ProQ/FINO family; Region: ProQ; pfam04352 216592009987 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter, score 4.2e-111 216592009988 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 216592009989 GAF domain; Region: GAF_2; pfam13185 216592009990 HMMPfam hit to PF01590, GAF domain, score 1.4e-10 216592009991 PS01320 Uncharacterized protein family UPF0067 signature. 216592009992 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 216592009993 Paraquat-inducible protein A; Region: PqiA; pfam04403 216592009994 Paraquat-inducible protein A; Region: PqiA; pfam04403 216592009995 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 5.9e-104 216592009996 8 probable transmembrane helices predicted for EC042_1998 by TMHMM2.0 at aa 65-84, 119-141, 162-184, 188-210, 266-288, 316-338, 351-373 and 383-405 216592009997 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 3.6e-105 216592009998 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 216592009999 mce related protein; Region: MCE; pfam02470 216592010000 mce related protein; Region: MCE; pfam02470 216592010001 mce related protein; Region: MCE; pfam02470 216592010002 mce related protein; Region: MCE; pfam02470 216592010003 mce related protein; Region: MCE; pfam02470 216592010004 HMMPfam hit to PF02470, mce related protein, score 0.0013 216592010005 1 probable transmembrane helix predicted for EC042_1999 by TMHMM2.0 at aa 34-53 216592010006 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 216592010007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592010008 S-adenosylmethionine binding site [chemical binding]; other site 216592010009 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 216592010010 PS01153 NOL1/NOP2/sun family signature. 216592010011 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 8.8e-114 216592010012 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 216592010013 HMMPfam hit to PF07351, Protein of unknown function (DUF1480), score 1.2e-69 216592010014 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 216592010015 HMMPfam hit to PF07358, Protein of unknown function (DUF1482), score 1.5e-41 216592010016 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 216592010017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216592010018 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 7.4e-17 216592010019 PS00125 Serine/threonine specific protein phosphatases signature. 216592010020 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 216592010021 1 probable transmembrane helix predicted for EC042_2004 by TMHMM2.0 at aa 5-27 216592010022 Signal peptide predicted for EC042_2004 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 20 and 21 216592010023 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 216592010024 HMMPfam hit to PF05425, Copper resistance protein D, score 3.5e-139 216592010025 8 probable transmembrane helices predicted for EC042_2005 by TMHMM2.0 at aa 11-30, 51-73, 93-110, 117-136, 151-170, 190-212, 227-249 and 262-284 216592010026 hypothetical protein; Provisional; Region: PRK10301 216592010027 HMMPfam hit to PF04234, Copper resistance protein CopC, score 1e-70 216592010028 Signal peptide predicted for EC042_2006 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.889 between residues 26 and 27 216592010029 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 216592010030 HMMPfam hit to PF06440, DNA polymerase III, theta subunit, score 7.1e-57 216592010031 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216592010032 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 216592010033 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase, score 7.4e-22 216592010034 exodeoxyribonuclease X; Provisional; Region: PRK07983 216592010035 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216592010036 active site 216592010037 catalytic site [active] 216592010038 substrate binding site [chemical binding]; other site 216592010039 HMMPfam hit to PF00929, Exonuclease, score 1.8e-36 216592010040 protease 2; Provisional; Region: PRK10115 216592010041 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216592010042 HMMPfam hit to PF00326, Prolyl oligopeptidase family, score 3.9e-106 216592010043 PS00708 Prolyl endopeptidase family serine active site. 216592010044 HMMPfam hit to PF02897, Prolyl oligopeptidase, N-terminal beta, score 5.9e-170 216592010045 Transposase IS200 like; Region: Y1_Tnp; pfam01797 216592010046 HMMPfam hit to PF01797, Transposase IS200 like, score 4.8e-24 216592010047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 216592010048 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 216592010049 Probable transposase; Region: OrfB_IS605; pfam01385 216592010050 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 216592010051 HMMPfam hit to PF01385, Probable transposase, score 3.8e-81 216592010052 HMMPfam hit to PF07282, Putative transposase DNA-binding domai, score 9.3e-38 216592010053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 216592010054 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 216592010055 putative metal binding site [ion binding]; other site 216592010056 HMMPfam hit to PF04391, Protein of unknown function (DUF533), score 3.4e-109 216592010057 2 probable transmembrane helices predicted for EC042_2013 by TMHMM2.0 at aa 26-45 and 52-74 216592010058 Signal peptide predicted for EC042_2013 by SignalP 2.0 HMM (Signal peptide probability 0.844) with cleavage site probability 0.572 between residues 23 and 24 216592010059 hypothetical protein; Provisional; Region: PRK13680 216592010060 Signal peptide predicted for EC042_2014 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.955 between residues 21 and 22 216592010061 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592010062 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 216592010063 HMMPfam hit to PF07130, YebG protein, score 1.9e-53 216592010064 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 216592010065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216592010066 ATP-grasp domain; Region: ATP-grasp; pfam02222 216592010067 HMMPfam hit to PF02222, ATP-grasp domain, score 1.9e-27 216592010068 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 216592010069 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216592010070 active site 216592010071 intersubunit interface [polypeptide binding]; other site 216592010072 catalytic residue [active] 216592010073 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 1.2e-142 216592010074 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 216592010075 PS00159 KDPG and KHG aldolases active site. 216592010076 phosphogluconate dehydratase; Validated; Region: PRK09054 216592010077 6-phosphogluconate dehydratase; Region: edd; TIGR01196 216592010078 HMMPfam hit to PF00920, Dehydratase family, score 2.1e-285 216592010079 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 216592010080 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 216592010081 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 216592010082 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216592010083 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216592010084 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 6e-207 216592010085 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 2.8e-107 216592010086 PS00069 Glucose-6-phosphate dehydrogenase active site. 216592010087 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 216592010088 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216592010089 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216592010090 putative active site [active] 216592010091 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 2.5e-59 216592010092 Predicted helix-turn-helix motif with score 1602.000, SD 4.64 at aa 35-56, sequence SSIAALALEANVSEPTVNRFCR 216592010093 HMMPfam hit to PF01380, SIS domain, score 2e-37 216592010094 pyruvate kinase; Provisional; Region: PRK05826 216592010095 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 216592010096 domain interfaces; other site 216592010097 active site 216592010098 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 9.2e-226 216592010099 PS00110 Pyruvate kinase active site signature. 216592010100 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 2.2e-63 216592010101 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216592010102 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216592010103 putative acyl-acceptor binding pocket; other site 216592010104 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 4.4e-160 216592010105 1 probable transmembrane helix predicted for EC042_2022 by TMHMM2.0 at aa 23-40 216592010106 putative peptidase; Provisional; Region: PRK11649 216592010107 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 216592010108 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592010109 Peptidase family M23; Region: Peptidase_M23; pfam01551 216592010110 HMMPfam hit to PF01551, Peptidase family M23, score 5.8e-52 216592010111 HMMPfam hit to PF01476, LysM domain, score 1.8e-06 216592010112 1 probable transmembrane helix predicted for EC042_2023 by TMHMM2.0 at aa 21-40 216592010113 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 216592010114 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 216592010115 metal binding site [ion binding]; metal-binding site 216592010116 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 3.2e-30 216592010117 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 216592010118 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216592010119 HMMPfam hit to PF00005, ABC transporter, score 1.6e-49 216592010120 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010121 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216592010122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592010123 ABC-ATPase subunit interface; other site 216592010124 dimer interface [polypeptide binding]; other site 216592010125 putative PBP binding regions; other site 216592010126 HMMPfam hit to PF00950, ABC 3 transport family, score 3e-128 216592010127 Signal peptide predicted for EC042_2026 by SignalP 2.0 HMM (Signal peptide probability 0.802) with cleavage site probability 0.367 between residues 19 and 20 216592010128 7 probable transmembrane helices predicted for EC042_2026 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 170-192, 213-235 and 239-256 216592010129 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 216592010130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592010131 Walker A motif; other site 216592010132 ATP binding site [chemical binding]; other site 216592010133 Walker B motif; other site 216592010134 arginine finger; other site 216592010135 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 216592010136 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 3.6e-55 216592010137 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.6e-31 216592010138 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010139 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 1.7e-28 216592010140 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 216592010141 RuvA N terminal domain; Region: RuvA_N; pfam01330 216592010142 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 216592010143 HMMPfam hit to PF07499, RuvA, C-terminal domain, score 1.5e-19 216592010144 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.14 216592010145 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.73 216592010146 HMMPfam hit to PF01330, RuvA N terminal domain, score 1.4e-33 216592010147 hypothetical protein; Provisional; Region: PRK11470 216592010148 HMMPfam hit to PF06520, Protein of unknown function (DUF1105), score 4.9e-136 216592010149 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 216592010150 active site 216592010151 putative DNA-binding cleft [nucleotide binding]; other site 216592010152 dimer interface [polypeptide binding]; other site 216592010153 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 1.6e-99 216592010154 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 216592010155 hypothetical protein; Validated; Region: PRK00110 216592010156 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 3.5e-151 216592010157 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 216592010158 nudix motif; other site 216592010159 HMMPfam hit to PF00293, NUDIX domain, score 3.8e-28 216592010160 PS00893 mutT domain signature. 216592010161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 216592010162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 216592010163 dimer interface [polypeptide binding]; other site 216592010164 anticodon binding site; other site 216592010165 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 216592010166 homodimer interface [polypeptide binding]; other site 216592010167 motif 1; other site 216592010168 active site 216592010169 motif 2; other site 216592010170 GAD domain; Region: GAD; pfam02938 216592010171 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 216592010172 motif 3; other site 216592010173 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 9.8e-20 216592010174 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592010175 HMMPfam hit to PF02938, GAD domain, score 8.3e-51 216592010176 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592010177 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 3.4e-28 216592010178 Isochorismatase family; Region: Isochorismatase; pfam00857 216592010179 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216592010180 catalytic triad [active] 216592010181 conserved cis-peptide bond; other site 216592010182 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216592010183 HMMPfam hit to PF00857, Isochorismatase family, score 1.1e-82 216592010184 hypothetical protein; Provisional; Region: PRK10302 216592010185 HMMPfam hit to PF01904, Protein of unknown function DUF72, score 2.2e-88 216592010186 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 216592010187 3 probable transmembrane helices predicted for EC042_2036 by TMHMM2.0 at aa 12-34, 81-103 and 116-138 216592010188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592010189 S-adenosylmethionine binding site [chemical binding]; other site 216592010190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592010191 S-adenosylmethionine binding site [chemical binding]; other site 216592010192 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 216592010193 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 216592010194 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 216592010195 molybdopterin cofactor binding site [chemical binding]; other site 216592010196 substrate binding site [chemical binding]; other site 216592010197 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 216592010198 molybdopterin cofactor binding site; other site 216592010199 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.1e-46 216592010200 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592010201 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3e-162 216592010202 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592010203 Signal peptide predicted for EC042_2039 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 31 and 32 216592010204 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 216592010205 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 216592010206 PS00190 Cytochrome c family heme-binding site signature. 216592010207 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 4.1e-110 216592010208 PS00190 Cytochrome c family heme-binding site signature. 216592010209 PS00190 Cytochrome c family heme-binding site signature. 216592010210 PS00190 Cytochrome c family heme-binding site signature. 216592010211 PS00190 Cytochrome c family heme-binding site signature. 216592010212 Signal peptide predicted for EC042_2040 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.935 between residues 26 and 27 216592010213 1 probable transmembrane helix predicted for EC042_2040 by TMHMM2.0 at aa 7-26 216592010214 copper homeostasis protein CutC; Provisional; Region: PRK11572 216592010215 HMMPfam hit to PF03932, CutC family, score 1.6e-135 216592010216 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 216592010217 putative metal binding site [ion binding]; other site 216592010218 HMMPfam hit to PF06185, Protein of unknown function (DUF991), score 1.4e-126 216592010219 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 216592010220 arginyl-tRNA synthetase; Region: argS; TIGR00456 216592010221 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216592010222 active site 216592010223 HIGH motif; other site 216592010224 KMSK motif region; other site 216592010225 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 216592010226 tRNA binding surface [nucleotide binding]; other site 216592010227 anticodon binding site; other site 216592010228 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 2.2e-31 216592010229 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 5e-219 216592010230 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592010231 HMMPfam hit to PF05746, DALR anticodon binding domain, score 7.6e-54 216592010232 Flagellar protein FlhE; Region: FlhE; pfam06366 216592010233 HMMPfam hit to PF06366, Flagellar protein FlhE, score 3e-89 216592010234 Signal peptide predicted for EC042_2044 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 17 and 18 216592010235 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 216592010236 FHIPEP family; Region: FHIPEP; pfam00771 216592010237 HMMPfam hit to PF00771, FHIPEP family, score 0 216592010238 7 probable transmembrane helices predicted for EC042_2045 by TMHMM2.0 at aa 46-68, 72-89, 101-123, 138-160, 234-256, 276-298 and 310-332 216592010239 PS00994 Bacterial export FHIPEP family signature. 216592010240 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 216592010241 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 216592010242 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 3.2e-192 216592010243 4 probable transmembrane helices predicted for EC042_2046 by TMHMM2.0 at aa 34-53, 92-114, 145-167 and 188-210 216592010244 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010245 chemotaxis regulator CheZ; Provisional; Region: PRK11166 216592010246 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 2e-162 216592010247 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 216592010248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592010249 active site 216592010250 phosphorylation site [posttranslational modification] 216592010251 intermolecular recognition site; other site 216592010252 dimerization interface [polypeptide binding]; other site 216592010253 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-43 216592010254 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 216592010255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592010256 active site 216592010257 phosphorylation site [posttranslational modification] 216592010258 intermolecular recognition site; other site 216592010259 dimerization interface [polypeptide binding]; other site 216592010260 CheB methylesterase; Region: CheB_methylest; pfam01339 216592010261 HMMPfam hit to PF01339, CheB methylesterase, score 1.4e-134 216592010262 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.7e-34 216592010263 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 216592010264 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216592010265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592010266 S-adenosylmethionine binding site [chemical binding]; other site 216592010267 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 1.5e-98 216592010268 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha domain, score 1.2e-16 216592010269 methyl-accepting protein IV; Provisional; Region: PRK09793 216592010270 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 216592010271 dimer interface [polypeptide binding]; other site 216592010272 ligand binding site [chemical binding]; other site 216592010273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592010274 dimerization interface [polypeptide binding]; other site 216592010275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216592010276 dimer interface [polypeptide binding]; other site 216592010277 putative CheW interface [polypeptide binding]; other site 216592010278 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 9.1e-106 216592010279 PS00538 Bacterial chemotaxis sensory transducers signature. 216592010280 HMMPfam hit to PF00672, HAMP domain, score 3e-11 216592010281 2 probable transmembrane helices predicted for EC042_2051 by TMHMM2.0 at aa 10-32 and 187-209 216592010282 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 5.4e-56 216592010283 Signal peptide predicted for EC042_2051 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.487 between residues 34 and 35 216592010284 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 216592010285 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 216592010286 dimer interface [polypeptide binding]; other site 216592010287 ligand binding site [chemical binding]; other site 216592010288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592010289 dimerization interface [polypeptide binding]; other site 216592010290 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216592010291 dimer interface [polypeptide binding]; other site 216592010292 putative CheW interface [polypeptide binding]; other site 216592010293 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.4e-120 216592010294 PS00538 Bacterial chemotaxis sensory transducers signature. 216592010295 HMMPfam hit to PF00672, HAMP domain, score 6.1e-17 216592010296 2 probable transmembrane helices predicted for EC042_2052 by TMHMM2.0 at aa 15-37 and 197-219 216592010297 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 5.2e-44 216592010298 Signal peptide predicted for EC042_2052 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.321 between residues 26 and 27 216592010299 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216592010300 putative CheA interaction surface; other site 216592010301 HMMPfam hit to PF01584, CheW-like domain, score 1.3e-33 216592010302 chemotaxis protein CheA; Provisional; Region: PRK10547 216592010303 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216592010304 putative binding surface; other site 216592010305 active site 216592010306 CheY binding; Region: CheY-binding; pfam09078 216592010307 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216592010308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592010309 ATP binding site [chemical binding]; other site 216592010310 Mg2+ binding site [ion binding]; other site 216592010311 G-X-G motif; other site 216592010312 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216592010313 HMMPfam hit to PF01584, CheW-like domain, score 8.4e-29 216592010314 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.2e-29 216592010315 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 6.8e-30 216592010316 HMMPfam hit to PF01627, Hpt domain, score 8.7e-16 216592010317 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592010318 flagellar motor protein MotB; Validated; Region: motB; PRK09041 216592010319 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 216592010320 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592010321 ligand binding site [chemical binding]; other site 216592010322 HMMPfam hit to PF00691, OmpA family, score 9.6e-37 216592010323 1 probable transmembrane helix predicted for EC042_2055 by TMHMM2.0 at aa 21-43 216592010324 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 216592010325 flagellar motor protein MotA; Validated; Region: PRK09110 216592010326 4 probable transmembrane helices predicted for EC042_2056 by TMHMM2.0 at aa 7-29, 34-51, 171-190 and 205-227 216592010327 PS01307 Flagellar motor protein motA family signature. 216592010328 transcriptional activator FlhC; Provisional; Region: PRK12722 216592010329 HMMPfam hit to PF05280, Flagellar transcriptional activator (FlhC), score 1.4e-157 216592010330 transcriptional activator FlhD; Provisional; Region: PRK02909 216592010331 HMMPfam hit to PF05247, Flagellar transcriptional activator (FlhD), score 3.6e-74 216592010332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592010333 Ligand Binding Site [chemical binding]; other site 216592010334 Signal peptide predicted for EC042_2059 by SignalP 2.0 HMM (Signal peptide probability 0.743) with cleavage site probability 0.739 between residues 21 and 22 216592010335 HMMPfam hit to PF00582, Universal stress protein family, score 5.6e-11 216592010336 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 216592010337 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 216592010338 active site 216592010339 homotetramer interface [polypeptide binding]; other site 216592010340 HMMPfam hit to PF00982, Glycosyltransferase family, score 1.5e-222 216592010341 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 216592010342 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 216592010343 HMMPfam hit to PF02358, Trehalose-phosphatase, score 5e-82 216592010344 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592010345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592010346 TM-ABC transporter signature motif; other site 216592010347 10 probable transmembrane helices predicted for EC042_2062 by TMHMM2.0 at aa 28-50, 54-73, 80-99, 103-125, 132-151, 171-193, 223-242, 252-270, 277-294 and 299-318 216592010348 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.8e-60 216592010349 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 216592010350 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592010351 Walker A/P-loop; other site 216592010352 ATP binding site [chemical binding]; other site 216592010353 Q-loop/lid; other site 216592010354 ABC transporter signature motif; other site 216592010355 Walker B; other site 216592010356 D-loop; other site 216592010357 H-loop/switch region; other site 216592010358 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592010359 HMMPfam hit to PF00005, ABC transporter, score 4.8e-22 216592010360 PS00211 ABC transporters family signature. 216592010361 PS00217 Sugar transport proteins signature 2. 216592010362 HMMPfam hit to PF00005, ABC transporter, score 3.5e-64 216592010363 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010364 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 216592010365 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 216592010366 ligand binding site [chemical binding]; other site 216592010367 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 6.6e-115 216592010368 Signal peptide predicted for EC042_2064 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 23 and 24 216592010369 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 216592010370 Ferritin-like domain; Region: Ferritin; pfam00210 216592010371 ferroxidase diiron center [ion binding]; other site 216592010372 HMMPfam hit to PF00210, Ferritin-like domain, score 5.6e-28 216592010373 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 216592010374 YecR-like lipoprotein; Region: YecR; pfam13992 216592010375 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 216592010376 Ferritin-like domain; Region: Ferritin; pfam00210 216592010377 ferroxidase diiron center [ion binding]; other site 216592010378 HMMPfam hit to PF00210, Ferritin-like domain, score 4e-45 216592010379 probable metal-binding protein; Region: matur_matur; TIGR03853 216592010380 tyrosine transporter TyrP; Provisional; Region: PRK15132 216592010381 aromatic amino acid transport protein; Region: araaP; TIGR00837 216592010382 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 5.4e-220 216592010383 Signal peptide predicted for EC042_2070 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.604 between residues 28 and 29 216592010384 11 probable transmembrane helices predicted for EC042_2070 by TMHMM2.0 at aa 7-29, 33-55, 78-100, 115-137, 144-166, 181-203, 216-238, 273-295, 308-330, 335-357 and 377-399 216592010385 PS00594 Aromatic amino acids permeases signature. 216592010386 hypothetical protein; Provisional; Region: PRK10396 216592010387 yecA family protein; Region: ygfB_yecA; TIGR02292 216592010388 SEC-C motif; Region: SEC-C; pfam02810 216592010389 HMMPfam hit to PF02810, SEC-C motif, score 1.1e-06 216592010390 PS00294 Prenyl group binding site (CAAX box). 216592010391 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 216592010392 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.2e-46 216592010393 4 probable transmembrane helices predicted for EC042_2073 by TMHMM2.0 at aa 7-29, 33-52, 121-143 and 147-169 216592010394 PS00379 CDP-alcohol phosphatidyltransferases signature. 216592010395 Signal peptide predicted for EC042_2073 by SignalP 2.0 HMM (Signal peptide probability 0.822) with cleavage site probability 0.220 between residues 45 and 46 216592010396 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 216592010397 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216592010398 GIY-YIG motif/motif A; other site 216592010399 active site 216592010400 catalytic site [active] 216592010401 putative DNA binding site [nucleotide binding]; other site 216592010402 metal binding site [ion binding]; metal-binding site 216592010403 UvrB/uvrC motif; Region: UVR; pfam02151 216592010404 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 216592010405 Helix-hairpin-helix motif; Region: HHH; pfam00633 216592010406 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.5e-05 216592010407 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.5e-05 216592010408 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.4e-12 216592010409 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 4.2e-32 216592010410 response regulator; Provisional; Region: PRK09483 216592010411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592010412 active site 216592010413 phosphorylation site [posttranslational modification] 216592010414 intermolecular recognition site; other site 216592010415 dimerization interface [polypeptide binding]; other site 216592010416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592010417 DNA binding residues [nucleotide binding] 216592010418 dimerization interface [polypeptide binding]; other site 216592010419 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 5.9e-27 216592010420 PS00622 Bacterial regulatory proteins, luxR family signature. 216592010421 HMMPfam hit to PF00072, Response regulator receiver domain, score 4e-46 216592010422 hypothetical protein; Provisional; Region: PRK10613 216592010423 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 216592010424 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216592010425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592010426 DNA binding residues [nucleotide binding] 216592010427 dimerization interface [polypeptide binding]; other site 216592010428 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.5e-25 216592010429 PS00622 Bacterial regulatory proteins, luxR family signature. 216592010430 Predicted helix-turn-helix motif with score 1360.000, SD 3.82 at aa 199-220, sequence KTSAEIAMILSISENTVNFHQK 216592010431 HMMPfam hit to PF03472, Autoinducer binding domain, score 5e-49 216592010432 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 216592010433 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216592010434 Walker A/P-loop; other site 216592010435 ATP binding site [chemical binding]; other site 216592010436 Q-loop/lid; other site 216592010437 ABC transporter signature motif; other site 216592010438 Walker B; other site 216592010439 D-loop; other site 216592010440 H-loop/switch region; other site 216592010441 HMMPfam hit to PF00005, ABC transporter, score 5.2e-74 216592010442 PS00211 ABC transporters family signature. 216592010443 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010444 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592010445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592010446 dimer interface [polypeptide binding]; other site 216592010447 conserved gate region; other site 216592010448 putative PBP binding loops; other site 216592010449 ABC-ATPase subunit interface; other site 216592010450 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.9e-37 216592010451 3 probable transmembrane helices predicted for EC042_2079 by TMHMM2.0 at aa 20-42, 54-76 and 185-207 216592010452 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592010453 D-cysteine desulfhydrase; Validated; Region: PRK03910 216592010454 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 216592010455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592010456 catalytic residue [active] 216592010457 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.2e-07 216592010458 cystine transporter subunit; Provisional; Region: PRK11260 216592010459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592010460 substrate binding pocket [chemical binding]; other site 216592010461 membrane-bound complex binding site; other site 216592010462 hinge residues; other site 216592010463 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 6.4e-105 216592010464 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592010465 Signal peptide predicted for EC042_2081 by SignalP 2.0 HMM (Signal peptide probability 0.880) with cleavage site probability 0.879 between residues 29 and 30 216592010466 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 216592010467 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like d, score 8.7e-12 216592010468 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 216592010469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592010470 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216592010471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592010472 DNA binding residues [nucleotide binding] 216592010473 HMMPfam hit to PF04545, Sigma-70, region, score 7.8e-19 216592010474 PS00716 Sigma-70 factors family signature 2. 216592010475 Predicted helix-turn-helix motif with score 1242.000, SD 3.42 at aa 205-226, sequence LNLKEIGAVLEVGESRVSQLHS 216592010476 HMMPfam hit to PF04539, Sigma-70 region, score 9.4e-23 216592010477 HMMPfam hit to PF04542, Sigma-70 region, score 4.1e-19 216592010478 PS00715 Sigma-70 factors family signature 1. 216592010479 flagellin; Validated; Region: PRK08026 216592010480 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216592010481 Flagellin protein; Region: FliC; pfam12445 216592010482 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216592010483 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 1.2e-37 216592010484 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.1e-80 216592010485 flagellar capping protein; Reviewed; Region: fliD; PRK08032 216592010486 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 216592010487 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 216592010488 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 7.2e-31 216592010489 HMMPfam hit to PF07196, Flagellin hook IN motif, score 1.7e-11 216592010490 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 1.9e-77 216592010491 Flagellar protein FliS; Region: FliS; cl00654 216592010492 HMMPfam hit to PF02561, Flagellar protein FliS, score 1.6e-70 216592010493 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 216592010494 HMMPfam hit to PF05400, Flagellar protein FliT, score 1.2e-82 216592010495 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 216592010496 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 216592010497 active site 216592010498 Na/Ca binding site [ion binding]; other site 216592010499 catalytic site [active] 216592010500 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 5.9e-95 216592010501 lipoprotein; Provisional; Region: PRK10397 216592010502 Signal peptide predicted for EC042_2089 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.742 between residues 19 and 20 216592010503 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592010504 putative inner membrane protein; Provisional; Region: PRK11099 216592010505 Signal peptide predicted for EC042_2090 by SignalP 2.0 HMM (Signal peptide probability 0.783) with cleavage site probability 0.452 between residues 40 and 41 216592010506 10 probable transmembrane helices predicted for EC042_2090 by TMHMM2.0 at aa 21-43, 81-103, 116-138, 148-170, 197-214, 224-246, 258-280, 284-306, 319-341 and 361-383 216592010507 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 3e-19 216592010508 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 3.3e-22 216592010509 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 216592010510 CPxP motif; other site 216592010511 HMMPfam hit to PF01206, SirA-like protein, score 4.7e-43 216592010512 PS01148 Uncharacterized protein family UPF0033 signature. 216592010513 hypothetical protein; Provisional; Region: PRK09951 216592010514 HMMPfam hit to PF02586, Uncharacterised ACR, COG2135, score 1.9e-71 216592010516 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.4e-12 216592010518 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 216592010519 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 2.1e-44 216592010520 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 216592010521 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 216592010522 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 216592010523 Signal peptide predicted for EC042_2097 by SignalP 2.0 HMM (Signal peptide probability 0.949) with cleavage site probability 0.937 between residues 43 and 44 216592010524 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 2.4e-96 216592010525 2 probable transmembrane helices predicted for EC042_2097 by TMHMM2.0 at aa 21-43 and 446-468 216592010526 flagellar motor switch protein FliG; Region: fliG; TIGR00207 216592010527 FliG C-terminal domain; Region: FliG_C; pfam01706 216592010528 HMMPfam hit to PF01706, FliG C-terminal domain, score 4.6e-63 216592010529 flagellar assembly protein H; Validated; Region: fliH; PRK05687 216592010530 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 216592010531 Flagellar assembly protein FliH; Region: FliH; pfam02108 216592010532 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 4.5e-154 216592010533 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 216592010534 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 216592010535 Walker A motif/ATP binding site; other site 216592010536 Walker B motif; other site 216592010537 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 3.5e-109 216592010538 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010539 PS00152 ATP synthase alpha and beta subunits signature. 216592010540 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 216592010541 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 216592010542 HMMPfam hit to PF02050, Flagellar FliJ protein, score 5.8e-124 216592010543 flagellar hook-length control protein; Provisional; Region: PRK10118 216592010544 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 216592010545 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 1.7e-52 216592010546 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 216592010547 Signal peptide predicted for EC042_2103 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.838 between residues 42 and 43 216592010548 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 3.7e-49 216592010549 1 probable transmembrane helix predicted for EC042_2103 by TMHMM2.0 at aa 13-35 216592010550 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592010551 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 216592010552 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 216592010553 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 9.2e-126 216592010554 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 216592010555 flagellar motor switch protein; Validated; Region: fliN; PRK05698 216592010556 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2.2e-36 216592010557 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 216592010558 Signal peptide predicted for EC042_2106 by SignalP 2.0 HMM (Signal peptide probability 0.816) with cleavage site probability 0.576 between residues 35 and 36 216592010559 1 probable transmembrane helix predicted for EC042_2106 by TMHMM2.0 at aa 10-32 216592010560 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 1.4e-48 216592010561 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 216592010562 Signal peptide predicted for EC042_2107 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592010563 5 probable transmembrane helices predicted for EC042_2107 by TMHMM2.0 at aa 7-26, 46-68, 88-105, 185-207 and 214-236 216592010564 HMMPfam hit to PF00813, FliP family, score 5.6e-126 216592010565 PS01060 Flagella transport protein fliP family signature 1. 216592010566 PS01061 Flagella transport protein fliP family signature 2. 216592010567 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 216592010568 Signal peptide predicted for EC042_2108 by SignalP 2.0 HMM (Signal peptide probability 0.974) with cleavage site probability 0.966 between residues 40 and 41 216592010569 HMMPfam hit to PF01313, Bacterial export proteins, family, score 8.4e-44 216592010570 2 probable transmembrane helices predicted for EC042_2108 by TMHMM2.0 at aa 20-42 and 52-74 216592010571 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 216592010572 HMMPfam hit to PF01311, Bacterial export proteins, family, score 2.7e-101 216592010573 6 probable transmembrane helices predicted for EC042_2109 by TMHMM2.0 at aa 15-34, 41-58, 73-95, 132-154, 179-201 and 214-236 216592010574 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 216592010575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592010576 DNA binding residues [nucleotide binding] 216592010577 dimerization interface [polypeptide binding]; other site 216592010578 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 8.8e-22 216592010579 PS00622 Bacterial regulatory proteins, luxR family signature. 216592010580 hypothetical protein; Provisional; Region: PRK10708 216592010581 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 216592010582 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 216592010583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592010584 active site 216592010585 motif I; other site 216592010586 motif II; other site 216592010587 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 216592010588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592010589 metal binding site [ion binding]; metal-binding site 216592010590 active site 216592010591 I-site; other site 216592010592 HMMPfam hit to PF00990, GGDEF domain, score 3.5e-71 216592010593 2 probable transmembrane helices predicted for EC042_2114 by TMHMM2.0 at aa 20-42 and 358-380 216592010594 Uncharacterized small protein [Function unknown]; Region: COG5475 216592010595 hypothetical protein; Provisional; Region: PRK10062 216592010596 HMMPfam hit to PF05661, Protein of unknown function (DUF808), score 2.4e-192 216592010597 5 probable transmembrane helices predicted for EC042_2115 by TMHMM2.0 at aa 80-102, 152-171, 175-197, 232-254 and 269-291 216592010598 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216592010599 EamA-like transporter family; Region: EamA; pfam00892 216592010600 10 probable transmembrane helices predicted for EC042_2116 by TMHMM2.0 at aa 7-29, 39-56, 68-87, 97-119, 126-145, 149-168, 175-197, 212-234, 241-260 and 270-292 216592010601 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.3e-28 216592010602 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.5e-20 216592010603 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 216592010604 additional DNA contacts [nucleotide binding]; other site 216592010605 mismatch recognition site; other site 216592010606 active site 216592010607 zinc binding site [ion binding]; other site 216592010608 DNA intercalation site [nucleotide binding]; other site 216592010609 HMMPfam hit to PF03852, DNA mismatch endonuclease Vsr, score 5.1e-50 216592010610 DNA cytosine methylase; Provisional; Region: PRK10458 216592010611 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216592010612 cofactor binding site; other site 216592010613 DNA binding site [nucleotide binding] 216592010614 substrate interaction site [chemical binding]; other site 216592010615 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 3.2e-86 216592010616 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216592010617 PS00094 C-5 cytosine-specific DNA methylases active site. 216592010618 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 216592010619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216592010620 Zn2+ binding site [ion binding]; other site 216592010621 Mg2+ binding site [ion binding]; other site 216592010622 HMMPfam hit to PF01966, HD domain, score 7e-20 216592010623 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 216592010624 2 probable transmembrane helices predicted for EC042_2120 by TMHMM2.0 at aa 47-69 and 93-115 216592010625 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592010626 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592010627 eyelet of channel; other site 216592010628 trimer interface [polypeptide binding]; other site 216592010629 Sequence divergence between 0157 and Uropathogenic strains, Outer membrane protein F precursor 216592010630 Signal peptide predicted for EC042_2121 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592010631 1 probable transmembrane helix predicted for EC042_2121 by TMHMM2.0 at aa 13-35 216592010632 HMMPfam hit to PF00267, Gram-negative porin, score 1.1e-164 216592010633 chaperone protein HchA; Provisional; Region: PRK04155 216592010634 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 216592010635 dimer interface [polypeptide binding]; other site 216592010636 metal binding site [ion binding]; metal-binding site 216592010637 potential oxyanion hole; other site 216592010638 potential catalytic triad [active] 216592010639 conserved cys residue [active] 216592010640 HMMPfam hit to PF01965, DJ-1/PfpI family, score 0.00026 216592010641 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216592010642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592010643 dimer interface [polypeptide binding]; other site 216592010644 phosphorylation site [posttranslational modification] 216592010645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592010646 ATP binding site [chemical binding]; other site 216592010647 Mg2+ binding site [ion binding]; other site 216592010648 G-X-G motif; other site 216592010649 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4e-21 216592010650 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.8e-13 216592010651 HMMPfam hit to PF00672, HAMP domain, score 8.7e-09 216592010652 2 probable transmembrane helices predicted for EC042_2124 by TMHMM2.0 at aa 10-32 and 159-181 216592010653 Signal peptide predicted for EC042_2124 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.431 between residues 23 and 24 216592010654 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 216592010655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592010656 active site 216592010657 phosphorylation site [posttranslational modification] 216592010658 intermolecular recognition site; other site 216592010659 dimerization interface [polypeptide binding]; other site 216592010660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592010661 DNA binding site [nucleotide binding] 216592010662 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.2e-20 216592010663 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.3e-36 216592010664 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 216592010665 active site 216592010666 homotetramer interface [polypeptide binding]; other site 216592010667 Signal peptide predicted for EC042_2126 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 23 and 24 216592010668 1 probable transmembrane helix predicted for EC042_2126 by TMHMM2.0 at aa 5-24 216592010669 HMMPfam hit to PF00576, Transthyretin precursor (formerly preal, score 3e-66 216592010670 PS00768 Transthyretin signature 1. 216592010671 PS00769 Transthyretin signature 2. 216592010672 TMAO/DMSO reductase; Reviewed; Region: PRK05363 216592010673 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 216592010674 Moco binding site; other site 216592010675 metal coordination site [ion binding]; other site 216592010676 Signal peptide predicted for EC042_2127 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 44 and 45 216592010677 HMMPfam hit to PF00174, Oxidoreductase molybdopterin binding d, score 0.00018 216592010678 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 216592010679 HMMPfam hit to PF05252, Uncharacterised protein family (UPF0191), score 1.8e-115 216592010680 6 probable transmembrane helices predicted for EC042_2128 by TMHMM2.0 at aa 13-30, 45-67, 80-102, 112-134, 150-167 and 177-199 216592010681 zinc/cadmium-binding protein; Provisional; Region: PRK10306 216592010682 Signal peptide predicted for EC042_2129 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.797 between residues 23 and 24 216592010683 Prophage 5. Absent in Uropathogenic, divergent in 0157, carrying exonuclease VIII 216592010684 2 probable transmembrane helices predicted for EC042_2130 by TMHMM2.0 at aa 7-29 and 71-93 216592010685 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592010686 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 216592010687 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 216592010688 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 216592010689 HMMPfam hit to PF06316, Enterobacterial Ail/Lom protein, score 1.6e-161 216592010690 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216592010691 PS00694 Enterobacterial virulence outer membrane protein signature 1. 216592010692 Signal peptide predicted for EC042_2134 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.964 between residues 24 and 25 216592010693 Phage-related protein, tail component [Function unknown]; Region: COG4733 216592010694 Putative phage tail protein; Region: Phage-tail_3; pfam13550 216592010695 Fibronectin type 3 domain; Region: FN3; smart00060 216592010696 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 216592010697 Fibronectin type III protein; Region: DUF3672; pfam12421 216592010698 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0034 216592010699 Phage-related protein, tail component [Function unknown]; Region: COG4723 216592010700 HMMPfam hit to PF06805, Bacteriophage lambda tail assembly prot, score 3.7e-114 216592010701 2 probable transmembrane helices predicted for EC042_2136 by TMHMM2.0 at aa 100-117 and 122-144 216592010702 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 216592010703 MPN+ (JAMM) motif; other site 216592010704 Zinc-binding site [ion binding]; other site 216592010705 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216592010706 NlpC/P60 family; Region: NLPC_P60; cl17555 216592010707 HMMPfam hit to PF00877, NlpC/P60 family, score 3.7e-23 216592010708 Phage-related protein [Function unknown]; Region: gp18; COG4672 216592010709 HMMPfam hit to PF05100, Phage minor tail protein L, score 7e-148 216592010710 Phage minor tail protein; Region: Phage_min_tail; pfam05939 216592010711 Phage-related minor tail protein [Function unknown]; Region: COG5281 216592010712 tape measure domain; Region: tape_meas_nterm; TIGR02675 216592010713 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 216592010714 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 216592010715 HMMPfam hit to PF06120, Tail length tape measure protein, score 1.9e-140 216592010716 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 216592010717 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 216592010718 HMMPfam hit to PF06222, Phage tail assembly chaperone, score 2.6e-67 216592010719 Immunoglobulin domain; Region: Ig_2; pfam13895 216592010720 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 216592010721 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 216592010722 HMMPfam hit to PF07772, TP901-1 ORF40-like protein, score 5.3e-51 216592010723 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 216592010724 HMMPfam hit to PF06264, Protein of unknown function (DUF1026), score 6.7e-43 216592010725 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 216592010726 oligomerization interface [polypeptide binding]; other site 216592010727 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 216592010728 Phage capsid family; Region: Phage_capsid; pfam05065 216592010729 HMMPfam hit to PF05065, Phage capsid family, score 4.2e-74 216592010730 PS00237 G-protein coupled receptors signature. 216592010731 Phage head maturation protease [General function prediction only]; Region: COG3740 216592010732 HMMPfam hit to PF04586, Caudovirus prohead protease, score 1.3e-62 216592010733 Phage portal protein; Region: Phage_portal; pfam04860 216592010734 Phage-related protein [Function unknown]; Region: COG4695 216592010735 HMMPfam hit to PF04860, Phage portal protein, score 1e-81 216592010736 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 216592010737 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 216592010738 HMMPfam hit to PF03354, Phage Terminase, score 4.7e-114 216592010739 PS00414 Profilin signature. 216592010740 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 216592010741 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010742 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 216592010743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216592010744 active site 216592010745 HMMPfam hit to PF01844, HNH endonuclease, score 7.5e-09 216592010746 PS00190 Cytochrome c family heme-binding site signature. 216592010747 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 216592010748 oligomerization interface [polypeptide binding]; other site 216592010749 HMMPfam hit to PF05135, Phage QLRG family, putative DNA packaging, score 9.6e-14 216592010750 Phage-related protein [Function unknown]; Region: COG4695 216592010751 Phage portal protein; Region: Phage_portal; pfam04860 216592010752 HMMPfam hit to PF04860, Phage portal protein, score 2.2e-97 216592010753 Predicted helix-turn-helix motif with score 1258.000, SD 3.47 at aa 303-324, sequence FSIEDIARMFNVSPIFLQEYSN 216592010754 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010755 Phage head maturation protease [General function prediction only]; Region: COG3740 216592010756 HMMPfam hit to PF04586, Caudovirus prohead protease, score 1.6e-60 216592010757 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 216592010758 Phage capsid family; Region: Phage_capsid; pfam05065 216592010759 HMMPfam hit to PF05065, Phage capsid family, score 1.5e-114 216592010760 PerC transcriptional activator; Region: PerC; pfam06069 216592010761 HMMPfam hit to PF06069, PerC transcriptional activator, score 9.8e-46 216592010762 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216592010763 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592010764 ssDNA binding site [nucleotide binding]; other site 216592010765 dimer interface [polypeptide binding]; other site 216592010766 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592010767 HMMPfam hit to PF00436, Single-strand binding protein family, score 1.4e-08 216592010768 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 216592010769 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592010770 PS00761 Signal peptidases I signature 3. 216592010771 Prophage antirepressor [Transcription]; Region: COG3617 216592010772 BRO family, N-terminal domain; Region: Bro-N; smart01040 216592010773 HMMPfam hit to PF02498, BRO family, N-terminal domain, score 2.1e-19 216592010774 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 216592010775 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 1.4e-10 216592010776 Predicted helix-turn-helix motif with score 1020.000, SD 2.66 at aa 37-58, sequence IREHECANRTGLSRSRRWVLEQ 216592010777 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 216592010778 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 8e-12 216592010779 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 216592010780 integrase; Provisional; Region: PRK09692 216592010781 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592010782 active site 216592010783 Int/Topo IB signature motif; other site 216592010784 HMMPfam hit to PF00589, Phage integrase family, score 1.8e-15 216592010785 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010786 HMMPfam hit to PF03354, Phage Terminase, score 8.6e-25 216592010787 Phage terminase, small subunit; Region: Terminase_4; pfam05119 216592010788 HMMPfam hit to PF05119, Phage terminase, small subunit, score 2.3e-34 216592010789 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 216592010790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216592010791 active site 216592010792 HMMPfam hit to PF01844, HNH endonuclease, score 3e-10 216592010793 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216592010794 HMMPfam hit to PF03245, Bacteriophage lysis protein, score 5.6e-109 216592010795 1 probable transmembrane helix predicted for EC042_2174 by TMHMM2.0 at aa 4-23 216592010796 Signal peptide predicted for EC042_2174 by SignalP 2.0 HMM (Signal peptide probability 0.692) with cleavage site probability 0.672 between residues 22 and 23 216592010797 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 216592010798 catalytic residues [active] 216592010799 HMMPfam hit to PF00959, Phage lysozyme, score 6.1e-34 216592010800 1 probable transmembrane helix predicted for EC042_2175 by TMHMM2.0 at aa 7-24 216592010801 Signal peptide predicted for EC042_2175 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.723 between residues 20 and 21 216592010802 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 216592010803 HMMPfam hit to PF07041, Protein of unknown function (DUF1327), score 3.8e-92 216592010804 Lysis protein S; Region: Lysis_S; pfam04971 216592010805 HMMPfam hit to PF04971, Lysis protein S, score 3.1e-52 216592010806 2 probable transmembrane helices predicted for EC042_2177 by TMHMM2.0 at aa 40-59 and 69-91 216592010807 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 216592010809 prophage 6. Absent in Uropathogenic, divergent in 0157, carrying exonuclease VIII 216592010810 Antitermination protein; Region: Antiterm; pfam03589 216592010811 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216592010812 HMMPfam hit to PF03589, Antitermination protein, score 7.8e-09 216592010813 HMMPfam hit to PF03589, Antitermination protein, score 9.2e-15 216592010814 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 216592010815 HMMPfam hit to PF05866, Endodeoxyribonuclease RusA, score 3.3e-47 216592010816 Protein of unknown function (DUF968); Region: DUF968; pfam06147 216592010817 HMMPfam hit to PF06914, Protein of unknown function (DUF1277), score 6.5e-203 216592010818 Hok/gef family; Region: HOK_GEF; pfam01848 216592010819 HMMPfam hit to PF01848, Hok/gef family, score 3.6e-27 216592010820 PS00556 Hok/gef family cell toxic proteins signature. 216592010821 1 probable transmembrane helix predicted for EC042_2186 by TMHMM2.0 at aa 25-44 216592010822 Signal peptide predicted for EC042_2186 by SignalP 2.0 HMM (Signal peptide probability 0.763) with cleavage site probability 0.670 between residues 22 and 23 216592010823 1 probable transmembrane helix predicted for EC042_2187 by TMHMM2.0 at aa 26-48 216592010824 Protein of unknown function (DUF551); Region: DUF551; pfam04448 216592010825 HMMPfam hit to PF04448, Protein of unknown function (DUF551), score 2.6e-43 216592010826 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 216592010827 HMMPfam hit to PF06163, Bacterial protein of unknown function (DUF97, score 3.9e-86 216592010828 Predicted helix-turn-helix motif with score 1410.000, SD 3.99 at aa 27-48, sequence GTIRQLSDEIGVSHTSVGRLCM 216592010829 Helix-turn-helix domain; Region: HTH_36; pfam13730 216592010830 primosomal protein DnaI; Provisional; Region: PRK02854 216592010831 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 216592010832 HMMPfam hit to PF06254, Protein of unknown function (DUF1019), score 1.7e-89 216592010833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592010834 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 216592010835 non-specific DNA binding site [nucleotide binding]; other site 216592010836 salt bridge; other site 216592010837 sequence-specific DNA binding site [nucleotide binding]; other site 216592010838 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216592010839 Catalytic site [active] 216592010840 HMMPfam hit to PF00717, Peptidase S24-like, score 2.6e-12 216592010841 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 216592010842 HMMPfam hit to PF07151, Protein of unknown function (DUF1391), score 1.1e-38 216592010843 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592010844 exonuclease VIII; Reviewed; Region: PRK09709 216592010845 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 216592010846 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 216592010847 active site 216592010848 catalytic site [active] 216592010849 substrate binding site [chemical binding]; other site 216592010850 HMMPfam hit to PF06630, Enterobacterial exodeoxyribonuclease VIII, score 1.5e-115 216592010851 HMMPfam hit to PF00929, Exonuclease, score 0.0075 216592010852 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 216592010853 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216592010854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216592010855 active site 216592010856 DNA binding site [nucleotide binding] 216592010857 Int/Topo IB signature motif; other site 216592010858 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.11 216592010859 HMMPfam hit to PF00589, Phage integrase family, score 7.8e-05 216592010860 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 216592010861 HMMPfam hit to PF06167, Protein of unknown function (DUF980), score 3.9e-163 216592010862 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592010863 Present in Uropathogenic, absent in 0157, putative siderophore cluster (regulation, biosysnthesis, transport and receptor) 216592010864 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592010865 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216592010866 active site 216592010867 Int/Topo IB signature motif; other site 216592010868 HMMPfam hit to PF00589, Phage integrase family, score 1.5e-38 216592010869 salicylate synthase Irp9; Reviewed; Region: PRK06772 216592010870 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216592010871 HMMPfam hit to PF00425, chorismate binding enzyme, score 1.3e-46 216592010872 muropeptide transporter; Validated; Region: ampG; cl17669 216592010873 12 probable transmembrane helices predicted for EC042_2209 by TMHMM2.0 at aa 59-78, 88-110, 131-153, 163-185, 198-220, 225-247, 277-299, 309-331, 338-360, 375-397, 404-426 and 431-453 216592010874 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.3e-10 216592010875 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216592010876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592010877 Walker A/P-loop; other site 216592010878 ATP binding site [chemical binding]; other site 216592010879 Q-loop/lid; other site 216592010880 ABC transporter signature motif; other site 216592010881 Walker B; other site 216592010882 D-loop; other site 216592010883 H-loop/switch region; other site 216592010884 HMMPfam hit to PF00005, ABC transporter, score 1.2e-53 216592010885 PS00211 ABC transporters family signature. 216592010886 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010887 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.0031 216592010888 5 probable transmembrane helices predicted for EC042_2210 by TMHMM2.0 at aa 34-56, 66-88, 139-161, 165-187 and 273-295 216592010889 Signal peptide predicted for EC042_2210 by SignalP 2.0 HMM (Signal peptide probability 0.966) with cleavage site probability 0.965 between residues 49 and 50 216592010890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592010891 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216592010892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592010893 Walker A/P-loop; other site 216592010894 ATP binding site [chemical binding]; other site 216592010895 Q-loop/lid; other site 216592010896 ABC transporter signature motif; other site 216592010897 Walker B; other site 216592010898 D-loop; other site 216592010899 H-loop/switch region; other site 216592010900 HMMPfam hit to PF00005, ABC transporter, score 2.2e-55 216592010901 PS00211 ABC transporters family signature. 216592010902 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010903 6 probable transmembrane helices predicted for EC042_2211 by TMHMM2.0 at aa 29-51, 61-80, 143-162, 166-184, 251-273 and 283-305 216592010904 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.9e-15 216592010905 Signal peptide predicted for EC042_2211 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.473 between residues 43 and 44 216592010906 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592010907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592010908 PS00041 Bacterial regulatory proteins, araC family signature. 216592010909 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 6.4e-09 216592010910 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 216592010911 Condensation domain; Region: Condensation; pfam00668 216592010912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216592010913 Nonribosomal peptide synthase; Region: NRPS; pfam08415 216592010914 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 216592010915 acyl-activating enzyme (AAE) consensus motif; other site 216592010916 AMP binding site [chemical binding]; other site 216592010917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592010918 S-adenosylmethionine binding site [chemical binding]; other site 216592010919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216592010920 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592010921 Condensation domain; Region: Condensation; pfam00668 216592010922 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216592010923 Nonribosomal peptide synthase; Region: NRPS; pfam08415 216592010924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592010925 PS00012 Phosphopantetheine attachment site. 216592010926 HMMPfam hit to PF00668, Condensation domain, score 1.8e-76 216592010927 PS00256 Adipokinetic hormone family signature. 216592010928 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.1e-141 216592010929 PS00455 Putative AMP-binding domain signature. 216592010930 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.8e-09 216592010931 HMMPfam hit to PF00668, Condensation domain, score 1e-73 216592010932 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 6.9e-05 216592010933 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 216592010934 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 216592010935 active site 216592010936 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216592010937 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 216592010938 Methyltransferase domain; Region: Methyltransf_12; pfam08242 216592010939 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 216592010940 KR domain; Region: KR; pfam08659 216592010941 NADP binding site [chemical binding]; other site 216592010942 active site 216592010943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592010944 Condensation domain; Region: Condensation; pfam00668 216592010945 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216592010946 Nonribosomal peptide synthase; Region: NRPS; pfam08415 216592010947 Methyltransferase domain; Region: Methyltransf_12; pfam08242 216592010948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592010949 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216592010950 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.5e-85 216592010951 PS00606 Beta-ketoacyl synthases active site. 216592010952 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216592010953 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 4.5e-80 216592010954 HMMPfam hit to PF00698, Acyl transferase domain, score 4.2e-57 216592010955 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.1e-05 216592010956 PS00012 Phosphopantetheine attachment site. 216592010957 HMMPfam hit to PF00668, Condensation domain, score 4.9e-31 216592010958 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 5.4e-12 216592010959 PS00012 Phosphopantetheine attachment site. 216592010960 HMMPfam hit to PF00975, Thioesterase domain, score 5.8e-14 216592010961 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 216592010962 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216592010963 HMMPfam hit to PF07414, Yersiniabactin synthetase thiazolinyl reduct, score 1.7e-231 216592010964 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 216592010965 HMMPfam hit to PF00975, Thioesterase domain, score 3.5e-77 216592010966 PS00435 Peroxidases proximal heme-ligand signature. 216592010967 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 216592010968 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 216592010969 acyl-activating enzyme (AAE) consensus motif; other site 216592010970 active site 216592010971 AMP binding site [chemical binding]; other site 216592010972 substrate binding site [chemical binding]; other site 216592010973 HMMPfam hit to PF00501, AMP-binding enzyme, score 7.2e-103 216592010974 PS00455 Putative AMP-binding domain signature. 216592010975 Predicted helix-turn-helix motif with score 1075.000, SD 2.85 at aa 196-217, sequence YNFSASAELCGISQQSVYLAVL 216592010976 PS00761 Signal peptidases I signature 3. 216592010977 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216592010978 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592010979 N-terminal plug; other site 216592010980 ligand-binding site [chemical binding]; other site 216592010981 Signal peptide predicted for EC042_2218 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.958 between residues 22 and 23 216592010982 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.9e-14 216592010983 HMMPfam hit to PF00593, TonB dependent receptor, score 4.8e-28 216592010984 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 216592010985 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 216592010986 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 216592010987 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 216592010988 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 216592010989 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592010990 PS00017 ATP/GTP-binding site motif A (P-loop). 216592010991 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.1e-29 216592010992 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.4e-23 216592010993 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.4e-24 216592010994 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 7.2e-28 216592010995 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216592010996 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216592010997 shikimate transporter; Provisional; Region: PRK09952 216592010998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592010999 putative substrate translocation pore; other site 216592011000 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.3e-21 216592011001 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.7e-19 216592011002 12 probable transmembrane helices predicted for EC042_2222 by TMHMM2.0 at aa 25-47, 62-84, 97-119, 129-151, 164-186, 196-215, 255-277, 287-309, 318-337, 342-361, 382-404 and 414-431 216592011003 PS00217 Sugar transport proteins signature 2. 216592011004 AMP nucleosidase; Provisional; Region: PRK08292 216592011005 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 216592011006 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 216592011007 HMMPfam hit to PF01048, Phosphorylase family, score 3.7e-99 216592011008 hypothetical protein; Provisional; Region: PRK12378 216592011009 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 1.2e-127 216592011010 MATE family multidrug exporter; Provisional; Region: PRK10189 216592011011 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 216592011012 11 probable transmembrane helices predicted for EC042_2225 by TMHMM2.0 at aa 100-122, 137-159, 172-191, 211-233, 245-267, 282-304, 317-339, 354-376, 403-425, 440-462 and 485-507 216592011013 HMMPfam hit to PF01554, MatE, score 7.2e-44 216592011014 HMMPfam hit to PF01554, MatE, score 2.9e-48 216592011015 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 216592011016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592011017 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 216592011018 putative substrate binding site [chemical binding]; other site 216592011019 dimerization interface [polypeptide binding]; other site 216592011020 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.6e-46 216592011021 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.5e-16 216592011022 PS00044 Bacterial regulatory proteins, lysR family signature. 216592011023 Predicted helix-turn-helix motif with score 1808.000, SD 5.34 at aa 17-38, sequence YNLTEVANMLFTSQSGVSRHIR 216592011024 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 216592011025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592011026 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 216592011027 putative dimerization interface [polypeptide binding]; other site 216592011028 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.1e-36 216592011029 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-19 216592011030 PS00044 Bacterial regulatory proteins, lysR family signature. 216592011031 Predicted helix-turn-helix motif with score 1549.000, SD 4.46 at aa 16-37, sequence GSLTQAAEVLHIAQPALSQQVA 216592011032 L,D-transpeptidase; Provisional; Region: PRK10190 216592011033 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216592011034 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 3.9e-66 216592011035 1 probable transmembrane helix predicted for EC042_2228 by TMHMM2.0 at aa 7-29 216592011036 Signal peptide predicted for EC042_2228 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.996 between residues 22 and 23 216592011037 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 216592011038 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 216592011039 putative dimer interface [polypeptide binding]; other site 216592011040 active site pocket [active] 216592011041 putative cataytic base [active] 216592011042 HMMPfam hit to PF02277, Phosphoribosyltransferase, score 1e-182 216592011043 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 216592011044 HMMPfam hit to PF02654, Cobalamin-5-phosphate synthase, score 1e-121 216592011045 5 probable transmembrane helices predicted for EC042_2230 by TMHMM2.0 at aa 13-30, 45-67, 69-91, 121-140 and 197-219 216592011046 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 216592011047 homotrimer interface [polypeptide binding]; other site 216592011048 Walker A motif; other site 216592011049 GTP binding site [chemical binding]; other site 216592011050 Walker B motif; other site 216592011051 HMMPfam hit to PF02283, Cobinamide kinase / cobinamide phosphate gua, score 1.4e-128 216592011052 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011053 Genomic island 1. Absent in 0157, divergent in Uropathogenic, carries transposases, hypothetical proteins and Pertactin domain-containing autotransporter protein) 216592011055 HMMPfam hit to PF00665, Integrase core domain, score 8.5e-10 216592011056 Transposase; Region: HTH_Tnp_1; cl17663 216592011057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592011058 HMMPfam hit to PF01527, Transposase, score 5.9e-06 216592011059 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 33-54, sequence IGVTAAARELSLYESQLYNWRS 216592011060 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 216592011061 homodimer interaction site [polypeptide binding]; other site 216592011062 substrate binding pocket [chemical binding]; other site 216592011063 active site 216592011064 HMMPfam hit to PF02126, Phosphotriesterase family, score 1.7e-17 216592011065 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 216592011066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 216592011067 Transposase; Region: DDE_Tnp_ISL3; pfam01610 216592011068 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 216592011069 Transposase; Region: DDE_Tnp_ISL3; pfam01610 216592011070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 216592011071 HMMPfam hit to PF01610, Transposase, score 2e-08 216592011072 Predicted helix-turn-helix motif with score 2086.000, SD 6.29 at aa 306-327, sequence CSFREISRITGLSRVTVSRWVG 216592011074 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 216592011075 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592011076 PS00881 Protein splicing signature. 216592011077 1 probable transmembrane helix predicted for EC042_2238 by TMHMM2.0 at aa 40-62 216592011078 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 216592011079 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 216592011080 Predicted GTPase [General function prediction only]; Region: COG3596 216592011081 YfjP GTPase; Region: YfjP; cd11383 216592011082 G1 box; other site 216592011083 GTP/Mg2+ binding site [chemical binding]; other site 216592011084 Switch I region; other site 216592011085 G2 box; other site 216592011086 Switch II region; other site 216592011087 G3 box; other site 216592011088 G4 box; other site 216592011089 G5 box; other site 216592011090 HMMPfam hit to PF01926, GTPase of unknown function, score 7.9e-20 216592011091 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011092 1 probable transmembrane helix predicted for EC042_2242 by TMHMM2.0 at aa 28-45 216592011093 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592011094 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592011095 hypothetical protein; Provisional; Region: PRK09945 216592011096 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592011097 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592011098 Autotransporter beta-domain; Region: Autotransporter; smart00869 216592011099 Signal peptide predicted for EC042_2242 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.994 between residues 52 and 53 216592011100 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592011101 HMMPfam hit to PF05594, no description, score 4 216592011102 HMMPfam hit to PF03212, Pertactin, score 1.4e-06 216592011103 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011104 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.6e-30 216592011105 Signal peptide predicted for EC042_2243 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.654 between residues 35 and 36 216592011106 8 probable transmembrane helices predicted for EC042_2243 by TMHMM2.0 at aa 7-29, 33-52, 64-83, 98-115, 136-158, 168-187, 680-702 and 717-739 216592011107 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011108 Signal peptide predicted for EC042_2244 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.995 between residues 25 and 26 216592011109 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 216592011110 Domain of unknown function (DUF932); Region: DUF932; pfam06067 216592011111 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 1e-221 216592011112 Antirestriction protein; Region: Antirestrict; pfam03230 216592011113 HMMPfam hit to PF03230, Antirestriction protein, score 4.1e-51 216592011114 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 216592011115 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216592011116 MPN+ (JAMM) motif; other site 216592011117 Zinc-binding site [ion binding]; other site 216592011118 HMMPfam hit to PF04002, RadC, DNA repair protein, score 1.8e-82 216592011119 PS01302 DNA repair protein radC family signature. 216592011120 Protein of unknown function (DUF987); Region: DUF987; pfam06174 216592011121 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 216592011122 HMMPfam hit to PF06154, YagB/YeeU/YfjZ family, score 1.2e-83 216592011123 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 216592011124 HMMPfam hit to PF06755, Protein of unknown function (DUF1219), score 1.8e-105 216592011125 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 216592011126 G4 box; other site 216592011127 G5 box; other site 216592011128 hypothetical protein; Provisional; Region: PRK05423 216592011129 HMMPfam hit to PF04363, Protein of unknown function (DUF496), score 1.5e-69 216592011130 Predicted membrane protein [Function unknown]; Region: COG1289 216592011131 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592011132 5 probable transmembrane helices predicted for EC042_2253 by TMHMM2.0 at aa 20-42, 47-66, 73-92, 96-114 and 121-143 216592011133 DNA gyrase inhibitor; Provisional; Region: PRK10016 216592011134 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 2.2e-37 216592011135 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216592011136 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 216592011137 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 216592011138 HMMPfam hit to PF00144, Beta-lactamase, score 0.0021 216592011139 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 5.5e-150 216592011140 Signal peptide predicted for EC042_2255 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.902 between residues 23 and 24 216592011141 exonuclease I; Provisional; Region: sbcB; PRK11779 216592011142 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 216592011143 active site 216592011144 catalytic site [active] 216592011145 substrate binding site [chemical binding]; other site 216592011146 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 216592011147 HMMPfam hit to PF00929, Exonuclease, score 2.9e-34 216592011148 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216592011149 HMMPfam hit to PF00324, Amino acid permease, score 2.7e-20 216592011150 12 probable transmembrane helices predicted for EC042_2257 by TMHMM2.0 at aa 20-38, 53-75, 96-118, 133-151, 158-180, 200-219, 240-262, 289-311, 342-364, 368-385, 398-417 and 422-439 216592011151 Signal peptide predicted for EC042_2257 by SignalP 2.0 HMM (Signal peptide probability 0.736) with cleavage site probability 0.589 between residues 33 and 34 216592011152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592011153 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 216592011154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592011155 dimerization interface [polypeptide binding]; other site 216592011156 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011157 HMMPfam hit to PF03466, LysR substrate binding domain, score 8e-26 216592011158 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.3e-15 216592011159 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216592011160 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 216592011161 putative NAD(P) binding site [chemical binding]; other site 216592011162 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011163 Signal peptide predicted for EC042_2259 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.434 between residues 24 and 25 216592011164 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 216592011165 HMMPfam hit to PF06769, Protein of unknown function (DUF1224), score 2e-60 216592011166 antitoxin YefM; Provisional; Region: PRK11409 216592011167 HMMPfam hit to PF02604, Phd_YefM, score 3.4e-31 216592011168 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 216592011169 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 216592011170 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 216592011171 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 2.2e-86 216592011172 PS01316 ATP phosphoribosyltransferase signature. 216592011173 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 216592011174 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 216592011175 NAD binding site [chemical binding]; other site 216592011176 dimerization interface [polypeptide binding]; other site 216592011177 product binding site; other site 216592011178 substrate binding site [chemical binding]; other site 216592011179 zinc binding site [ion binding]; other site 216592011180 catalytic residues [active] 216592011181 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 2.4e-276 216592011182 PS00611 Histidinol dehydrogenase signature. 216592011183 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 216592011184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592011185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592011186 homodimer interface [polypeptide binding]; other site 216592011187 catalytic residue [active] 216592011188 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.2e-73 216592011189 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216592011190 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 216592011191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592011192 active site 216592011193 motif I; other site 216592011194 motif II; other site 216592011195 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 216592011196 putative active site pocket [active] 216592011197 4-fold oligomerization interface [polypeptide binding]; other site 216592011198 metal binding residues [ion binding]; metal-binding site 216592011199 3-fold/trimer interface [polypeptide binding]; other site 216592011200 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 7.1e-109 216592011201 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 216592011202 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 216592011203 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 216592011204 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216592011205 putative active site [active] 216592011206 oxyanion strand; other site 216592011207 catalytic triad [active] 216592011208 PS00136 Serine proteases, subtilase family, aspartic acid active site. 216592011209 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1e-43 216592011210 PS00442 Glutamine amidotransferases class-I active site. 216592011211 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 216592011212 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 216592011213 catalytic residues [active] 216592011214 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 4.9e-108 216592011215 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 216592011216 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 216592011217 substrate binding site [chemical binding]; other site 216592011218 glutamase interaction surface [polypeptide binding]; other site 216592011219 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 9.2e-120 216592011220 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 216592011221 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 216592011222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 216592011223 metal binding site [ion binding]; metal-binding site 216592011224 PS00430 TonB-dependent receptor proteins signature 1. 216592011225 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 7.8e-47 216592011226 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 3.6e-51 216592011227 chain length determinant protein WzzB; Provisional; Region: PRK15471 216592011228 Chain length determinant protein; Region: Wzz; pfam02706 216592011229 2 probable transmembrane helices predicted for EC042_2270 by TMHMM2.0 at aa 45-64 and 307-326 216592011230 HMMPfam hit to PF02706, Chain length determinant protein, score 1.8e-29 216592011231 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 216592011232 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216592011233 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216592011234 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 216592011235 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 2.8e-07 216592011236 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 2.7e-36 216592011237 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 3e-44 216592011238 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216592011239 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 216592011240 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 216592011241 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 8.9e-239 216592011242 PS00461 6-phosphogluconate dehydrogenase signature. 216592011243 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 5e-130 216592011244 Sequence divergence between 0157 and Uropathogenic strains, O antigen genes (x5); O-antigen gene cluster 216592011245 Sequence divergence between 0157 and Uropathogenic strains, O antigen genes (x5) 216592011246 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216592011247 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216592011248 12 probable transmembrane helices predicted for EC042_2273 by TMHMM2.0 at aa 13-32, 42-64, 77-99, 109-126, 138-160, 170-192, 205-227, 247-269, 282-304, 319-341, 346-368 and 378-400 216592011249 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 216592011250 12 probable transmembrane helices predicted for EC042_2274 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-118, 137-159, 179-201, 222-241, 256-273, 280-302, 364-386, 393-410 and 414-435 216592011251 Signal peptide predicted for EC042_2274 by SignalP 2.0 HMM (Signal peptide probability 0.717) with cleavage site probability 0.618 between residues 35 and 36 216592011252 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 216592011253 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 216592011254 active site 216592011255 substrate binding site [chemical binding]; other site 216592011256 metal binding site [ion binding]; metal-binding site 216592011257 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 7.1e-12 216592011258 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 5.1e-18 216592011259 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 2.6e-26 216592011260 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 2.2e-38 216592011261 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216592011262 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 216592011263 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216592011264 Substrate binding site; other site 216592011265 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 216592011266 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, score 2.2e-124 216592011267 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.5e-123 216592011268 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 216592011269 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 216592011270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216592011271 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216592011272 2 probable transmembrane helices predicted for EC042_2278 by TMHMM2.0 at aa 60-82 and 121-143 216592011273 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 216592011274 active site 216592011275 tetramer interface; other site 216592011276 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.2e-11 216592011277 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 216592011278 Signal peptide predicted for EC042_2280 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.939 between residues 28 and 29 216592011279 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 216592011280 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 216592011281 putative ADP-binding pocket [chemical binding]; other site 216592011282 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.3e-40 216592011283 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 216592011284 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 216592011285 HMMPfam hit to PF04230, Polysaccharide pyruvyl transferase, score 2.8e-157 216592011286 colanic acid exporter; Provisional; Region: PRK10459 216592011287 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 216592011288 12 probable transmembrane helices predicted for EC042_2283 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 156-178, 199-218, 233-255, 284-306, 326-348, 355-377, 381-403, 416-438 and 448-467 216592011289 PS00287 Cysteine proteases inhibitors signature. 216592011290 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1.8e-76 216592011291 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 216592011292 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 216592011293 HMMPfam hit to PF02397, Bacterial sugar transferase, score 2.4e-43 216592011294 5 probable transmembrane helices predicted for EC042_2284 by TMHMM2.0 at aa 12-34, 44-66, 79-101, 111-130 and 279-300 216592011295 PS01047 Heavy-metal-associated domain. 216592011296 phosphomannomutase CpsG; Provisional; Region: PRK15414 216592011297 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 216592011298 active site 216592011299 substrate binding site [chemical binding]; other site 216592011300 metal binding site [ion binding]; metal-binding site 216592011301 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 1.8e-31 216592011302 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1.2e-55 216592011303 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.6e-58 216592011304 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 1.7e-49 216592011305 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216592011306 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 216592011307 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216592011308 Substrate binding site; other site 216592011309 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 216592011310 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, score 1.6e-133 216592011311 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.9e-149 216592011312 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 216592011313 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 216592011314 HMMPfam hit to PF00534, Glycosyl transferases group, score 2.6e-20 216592011315 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 216592011316 active site 216592011317 GDP-Mannose binding site [chemical binding]; other site 216592011318 dimer interface [polypeptide binding]; other site 216592011319 modified nudix motif 216592011320 metal binding site [ion binding]; metal-binding site 216592011321 HMMPfam hit to PF00293, NUDIX domain, score 2.1e-24 216592011322 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 216592011323 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 216592011324 NADP binding site [chemical binding]; other site 216592011325 active site 216592011326 putative substrate binding site [chemical binding]; other site 216592011327 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 216592011328 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 216592011329 NADP-binding site; other site 216592011330 homotetramer interface [polypeptide binding]; other site 216592011331 substrate binding site [chemical binding]; other site 216592011332 homodimer interface [polypeptide binding]; other site 216592011333 active site 216592011334 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.9e-13 216592011335 PS00061 Short-chain dehydrogenases/reductases family signature. 216592011336 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 216592011337 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 216592011338 putative trimer interface [polypeptide binding]; other site 216592011339 putative active site [active] 216592011340 putative substrate binding site [chemical binding]; other site 216592011341 putative CoA binding site [chemical binding]; other site 216592011342 PS00101 Hexapeptide-repeat containing-transferases signature. 216592011343 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.1 216592011344 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 76 216592011345 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.14 216592011346 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216592011347 putative glycosyl transferase; Provisional; Region: PRK10063 216592011348 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 216592011349 metal-binding site 216592011350 HMMPfam hit to PF00535, Glycosyl transferase, score 1.3e-15 216592011351 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 216592011352 11 probable transmembrane helices predicted for EC042_2293 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103, 115-137, 172-191, 203-225, 245-264, 277-299, 326-348 and 369-391 216592011353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216592011354 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 216592011355 putative acyl transferase; Provisional; Region: PRK10191 216592011356 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216592011357 trimer interface [polypeptide binding]; other site 216592011358 active site 216592011359 substrate binding site [chemical binding]; other site 216592011360 CoA binding site [chemical binding]; other site 216592011361 PS00101 Hexapeptide-repeat containing-transferases signature. 216592011362 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.72 216592011363 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 10 216592011364 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 83 216592011365 putative glycosyl transferase; Provisional; Region: PRK10018 216592011366 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 216592011367 active site 216592011368 HMMPfam hit to PF00535, Glycosyl transferase, score 7.7e-32 216592011369 tyrosine kinase; Provisional; Region: PRK11519 216592011370 Chain length determinant protein; Region: Wzz; pfam02706 216592011371 Chain length determinant protein; Region: Wzz; cl15801 216592011372 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 216592011373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216592011374 2 probable transmembrane helices predicted for EC042_2297 by TMHMM2.0 at aa 44-66 and 439-461 216592011375 HMMPfam hit to PF02706, Chain length determinant protein, score 2.7e-92 216592011376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216592011377 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 216592011378 active site 216592011379 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 1.4e-66 216592011380 polysaccharide export protein Wza; Provisional; Region: PRK15078 216592011381 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216592011382 SLBB domain; Region: SLBB; pfam10531 216592011383 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 4.7e-67 216592011384 Signal peptide predicted for EC042_2299 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.613 between residues 33 and 34 216592011385 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592011386 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 216592011387 FOG: CBS domain [General function prediction only]; Region: COG0517 216592011388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216592011389 Transporter associated domain; Region: CorC_HlyC; smart01091 216592011390 7 probable transmembrane helices predicted for EC042_2300 by TMHMM2.0 at aa 31-53, 73-95, 110-127, 148-170, 175-194, 207-229 and 234-256 216592011391 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 1.6e-72 216592011392 HMMPfam hit to PF00571, CBS domain, score 9.4e-08 216592011393 HMMPfam hit to PF00571, CBS domain, score 4.3e-08 216592011394 HMMPfam hit to PF03471, Transporter associated domain, score 1.2e-22 216592011395 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 216592011396 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 216592011397 HMMPfam hit to PF01381, Helix-turn-helix, score 2.1e-05 216592011398 Predicted helix-turn-helix motif with score 1515.000, SD 4.35 at aa 48-69, sequence FSQAQAASALGVTQPRISELAR 216592011399 putative assembly protein; Provisional; Region: PRK10833 216592011400 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216592011401 HMMPfam hit to PF05170, AsmA family, score 4.9e-253 216592011402 Signal peptide predicted for EC042_2302 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.328 between residues 26 and 27 216592011403 1 probable transmembrane helix predicted for EC042_2302 by TMHMM2.0 at aa 7-26 216592011404 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216592011405 trimer interface [polypeptide binding]; other site 216592011406 active site 216592011407 HMMPfam hit to PF00692, dUTPase, score 1.4e-37 216592011408 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 216592011409 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 216592011410 ATP-binding site [chemical binding]; other site 216592011411 Sugar specificity; other site 216592011412 Pyrimidine base specificity; other site 216592011413 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2e-50 216592011414 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011415 Pseudogene. This CDS appears to have a frameshift mutation at (G)9 homopolymeric tract 216592011416 3 probable transmembrane helices predicted for EC042_2305 by TMHMM2.0 at aa 7-29, 39-58 and 65-87 216592011417 6 probable transmembrane helices predicted for EC042_2306 by TMHMM2.0 at aa 58-80, 93-110, 114-131, 138-155, 170-192 and 213-230 216592011418 HMMPfam hit to PF00785, PAC motif, score 2.1e-09 216592011419 HMMPfam hit to PF00785, PAC motif, score 4.1e-07 216592011420 HMMPfam hit to PF00785, PAC motif, score 0.00024 216592011421 HMMPfam hit to PF00990, GGDEF domain, score 5.6e-68 216592011422 HMMPfam hit to PF00563, EAL domain, score 6.7e-06 216592011423 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 216592011424 AlkA N-terminal domain; Region: AlkA_N; smart01009 216592011425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216592011426 minor groove reading motif; other site 216592011427 helix-hairpin-helix signature motif; other site 216592011428 substrate binding pocket [chemical binding]; other site 216592011429 active site 216592011430 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 1.9e-20 216592011431 PS00516 Alkylbase DNA glycosidases alkA family signature. 216592011432 HMMPfam hit to PF06029, AlkA N-terminal domain, score 1.4e-65 216592011433 putative chaperone; Provisional; Region: PRK11678 216592011434 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 216592011435 nucleotide binding site [chemical binding]; other site 216592011436 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216592011437 SBD interface [polypeptide binding]; other site 216592011438 PS00329 Heat shock hsp70 proteins family signature 2. 216592011439 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 216592011440 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216592011441 substrate binding site [chemical binding]; other site 216592011442 activation loop (A-loop); other site 216592011443 Y-family of DNA polymerases; Region: PolY; cl12025 216592011444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 216592011445 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 216592011446 Signal peptide predicted for EC042_2310 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.602 between residues 19 and 20 216592011447 Protein phosphatase 2C; Region: PP2C_2; pfam13672 216592011448 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 216592011449 metal ion-dependent adhesion site (MIDAS); other site 216592011450 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 216592011451 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592011452 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592011453 2 probable transmembrane helices predicted for EC042_2313 by TMHMM2.0 at aa 20-38 and 58-75 216592011454 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.2e-16 216592011455 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 216592011456 Protein export membrane protein; Region: SecD_SecF; cl14618 216592011457 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592011458 11 probable transmembrane helices predicted for EC042_2314 by TMHMM2.0 at aa 15-37, 345-362, 367-389, 396-418, 438-460, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022 216592011459 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 216592011460 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592011461 10 probable transmembrane helices predicted for EC042_2315 by TMHMM2.0 at aa 7-29, 336-353, 360-379, 389-411, 431-453, 468-490, 853-875, 895-917, 948-970 and 985-1007 216592011462 putative transporter; Provisional; Region: PRK10504 216592011463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592011464 putative substrate translocation pore; other site 216592011465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592011466 13 probable transmembrane helices predicted for EC042_2316 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 163-185, 197-214, 224-243, 263-282, 286-308, 329-351, 396-418 and 431-453 216592011467 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.7e-54 216592011468 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 216592011469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592011470 dimerization interface [polypeptide binding]; other site 216592011471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592011472 dimer interface [polypeptide binding]; other site 216592011473 phosphorylation site [posttranslational modification] 216592011474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592011475 ATP binding site [chemical binding]; other site 216592011476 Mg2+ binding site [ion binding]; other site 216592011477 G-X-G motif; other site 216592011478 2 probable transmembrane helices predicted for EC042_2317 by TMHMM2.0 at aa 13-35 and 168-190 216592011479 HMMPfam hit to PF00672, HAMP domain, score 3.8e-20 216592011480 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.9e-18 216592011481 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.3e-38 216592011482 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 216592011483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592011484 active site 216592011485 phosphorylation site [posttranslational modification] 216592011486 intermolecular recognition site; other site 216592011487 dimerization interface [polypeptide binding]; other site 216592011488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592011489 DNA binding site [nucleotide binding] 216592011490 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.3e-30 216592011491 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.5e-21 216592011492 PS00294 Prenyl group binding site (CAAX box). 216592011493 Uncharacterized conserved protein [Function unknown]; Region: COG3422 216592011494 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 216592011495 HMMPfam hit to PF07411, Domain of unknown function (DUF1508), score 1.1e-28 216592011496 HMMPfam hit to PF07411, Domain of unknown function (DUF1508), score 2.4e-27 216592011497 putative protease; Provisional; Region: PRK15452 216592011498 Peptidase family U32; Region: Peptidase_U32; pfam01136 216592011499 HMMPfam hit to PF01136, Peptidase family U32, score 1.3e-150 216592011500 PS01276 Peptidase family U32 signature. 216592011501 lipid kinase; Reviewed; Region: PRK13054 216592011502 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 216592011503 HMMPfam hit to PF00781, Diacylglycerol kinase catalytic domain (pres, score 3.6e-39 216592011504 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216592011505 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216592011506 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592011507 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 9e-79 216592011508 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592011509 PS00894 Bacterial regulatory proteins, deoR family signature. 216592011510 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 216592011511 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 216592011512 putative NAD(P) binding site [chemical binding]; other site 216592011513 catalytic Zn binding site [ion binding]; other site 216592011514 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.9e-86 216592011515 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592011516 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 216592011517 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 216592011518 11 probable transmembrane helices predicted for EC042_2324 by TMHMM2.0 at aa 4-26, 39-58, 91-113, 134-156, 176-198, 218-240, 300-322, 329-348, 353-372, 385-407 and 417-435 216592011519 HMMPfam hit to PF03611, PTS system Galactitol-specific IIC component, score 1.9e-197 216592011520 PS00962 Ribosomal protein S2 signature 1. 216592011521 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 216592011522 active site 216592011523 P-loop; other site 216592011524 phosphorylation site [posttranslational modification] 216592011525 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 1.5e-22 216592011526 Signal peptide predicted for EC042_2325 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 216592011527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592011528 active site 216592011529 phosphorylation site [posttranslational modification] 216592011530 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 1.9e-05 216592011531 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 216592011532 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 216592011533 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216592011534 intersubunit interface [polypeptide binding]; other site 216592011535 active site 216592011536 zinc binding site [ion binding]; other site 216592011537 Na+ binding site [ion binding]; other site 216592011538 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 6.1e-156 216592011539 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 216592011540 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 216592011541 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 216592011542 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 216592011543 putative active site; other site 216592011544 catalytic residue [active] 216592011545 nucleoside transporter; Region: 2A0110; TIGR00889 216592011546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592011547 putative substrate translocation pore; other site 216592011548 HMMPfam hit to PF03825, Nucleoside H+ symporter, score 2.4e-291 216592011549 12 probable transmembrane helices predicted for EC042_2330 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119, 132-154, 159-181, 211-233, 243-265, 274-291, 301-323, 336-358 and 378-400 216592011550 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-17 216592011551 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 216592011552 HMMPfam hit to PF03747, ADP-ribosylglycohydrolase, score 4.4e-113 216592011553 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592011554 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 216592011555 substrate binding site [chemical binding]; other site 216592011556 ATP binding site [chemical binding]; other site 216592011557 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.5e-61 216592011558 PS00583 pfkB family of carbohydrate kinases signature 1. 216592011559 PS00584 pfkB family of carbohydrate kinases signature 2. 216592011560 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216592011561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592011562 DNA-binding site [nucleotide binding]; DNA binding site 216592011563 UTRA domain; Region: UTRA; pfam07702 216592011564 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 3.1e-45 216592011565 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.4e-15 216592011566 Predicted helix-turn-helix motif with score 1126.000, SD 3.02 at aa 48-69, sequence PGERDLSQLTGVSRITVRKAMQ 216592011567 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 216592011568 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 216592011569 active site 216592011570 HMMPfam hit to PF01183, Glycosyl hydrolases family, score 4e-80 216592011571 1 probable transmembrane helix predicted for EC042_2334 by TMHMM2.0 at aa 13-30 216592011572 Signal peptide predicted for EC042_2334 by SignalP 2.0 HMM (Signal peptide probability 0.988) with cleavage site probability 0.560 between residues 27 and 28 216592011573 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 216592011574 dimer interface [polypeptide binding]; other site 216592011575 substrate binding site [chemical binding]; other site 216592011576 ATP binding site [chemical binding]; other site 216592011577 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 216592011578 substrate binding site [chemical binding]; other site 216592011579 multimerization interface [polypeptide binding]; other site 216592011580 ATP binding site [chemical binding]; other site 216592011581 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase family, score 3.4e-158 216592011582 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 216592011583 putative metal binding site [ion binding]; other site 216592011584 putative homodimer interface [polypeptide binding]; other site 216592011585 putative homotetramer interface [polypeptide binding]; other site 216592011586 putative homodimer-homodimer interface [polypeptide binding]; other site 216592011587 putative allosteric switch controlling residues; other site 216592011588 HMMPfam hit to PF02583, Uncharacterised BCR, COG1937, score 8.8e-30 216592011589 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 216592011590 6 probable transmembrane helices predicted for EC042_2338 by TMHMM2.0 at aa 10-32, 53-75, 90-107, 184-206, 216-238 and 258-280 216592011591 HMMPfam hit to PF03824, High-affinity nickel-transport protein, score 1.5e-79 216592011592 Predicted integral membrane protein [Function unknown]; Region: COG5455 216592011593 Fimbrial operon 7 216592011594 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 216592011595 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 216592011596 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 296-317, sequence TNLKEIAAKSKLTDTTVSIPIT 216592011597 Signal peptide predicted for EC042_2340 by SignalP 2.0 HMM (Signal peptide probability 0.631) with cleavage site probability 0.545 between residues 20 and 21 216592011598 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 216592011599 PapC N-terminal domain; Region: PapC_N; pfam13954 216592011600 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592011601 PapC C-terminal domain; Region: PapC_C; pfam13953 216592011602 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592011603 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592011604 Signal peptide predicted for EC042_2341 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.993 between residues 27 and 28 216592011605 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 216592011606 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592011607 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592011608 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 7.5e-25 216592011609 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.9e-66 216592011610 PS00635 Gram-negative pili assembly chaperone signature. 216592011611 1 probable transmembrane helix predicted for EC042_2342 by TMHMM2.0 at aa 7-29 216592011612 Signal peptide predicted for EC042_2342 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19 216592011613 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592011614 HMMPfam hit to PF00419, Fimbrial protein, score 0.0023 216592011615 1 probable transmembrane helix predicted for EC042_2343 by TMHMM2.0 at aa 5-23 216592011616 Signal peptide predicted for EC042_2343 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 22 and 23 216592011617 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 216592011618 1 probable transmembrane helix predicted for EC042_2344 by TMHMM2.0 at aa 4-23 216592011619 Signal peptide predicted for EC042_2344 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.699 between residues 22 and 23 216592011620 antiporter inner membrane protein; Provisional; Region: PRK11670 216592011621 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 216592011622 Walker A motif; other site 216592011623 PS01215 Mrp family signature. 216592011624 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011625 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 216592011626 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216592011627 active site 216592011628 HIGH motif; other site 216592011629 KMSKS motif; other site 216592011630 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216592011631 tRNA binding surface [nucleotide binding]; other site 216592011632 anticodon binding site; other site 216592011633 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 216592011634 dimer interface [polypeptide binding]; other site 216592011635 putative tRNA-binding site [nucleotide binding]; other site 216592011636 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 1.2e-05 216592011637 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592011638 HMMPfam hit to PF01588, Putative tRNA binding domain, score 2.5e-41 216592011639 Present in 0157, absent in Uropathogenic, molybdate metabolism regulators, deleted in Uropathogenic creating a fusion protein 216592011640 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216592011641 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 216592011642 HMMPfam hit to PF05406, WGR domain, score 6.1e-23 216592011643 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216592011644 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 216592011645 HMMPfam hit to PF05406, WGR domain, score 6e-24 216592011647 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011648 PS00070 Aldehyde dehydrogenases cysteine active site. 216592011650 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 9.2e-34 216592011651 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 216592011652 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 216592011653 metal ion-dependent adhesion site (MIDAS); other site 216592011654 HMMPfam hit to PF05762, VWA domain containing CoxE-like protein, score 5.6e-119 216592011655 HMMPfam hit to PF04434, SWIM zinc finger, score 0.001 216592011656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 216592011657 Signal peptide predicted for EC042_2356 by SignalP 2.0 HMM (Signal peptide probability 0.827) with cleavage site probability 0.311 between residues 28 and 29 216592011658 HMMPfam hit to PF06998, Protein of unknown function (DUF1307), score 1.3e-72 216592011659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 216592011660 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 216592011661 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 216592011662 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1.2e-37 216592011663 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1.2e-37 216592011664 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 216592011665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592011666 active site 216592011667 phosphorylation site [posttranslational modification] 216592011668 intermolecular recognition site; other site 216592011669 dimerization interface [polypeptide binding]; other site 216592011670 LytTr DNA-binding domain; Region: LytTR; pfam04397 216592011671 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 1.3e-27 216592011672 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.2e-40 216592011673 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 216592011674 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 216592011675 GAF domain; Region: GAF; pfam01590 216592011676 Histidine kinase; Region: His_kinase; pfam06580 216592011677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592011678 ATP binding site [chemical binding]; other site 216592011679 Mg2+ binding site [ion binding]; other site 216592011680 G-X-G motif; other site 216592011681 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 6.5e-10 216592011682 HMMPfam hit to PF06580, Histidine kinase, score 4.1e-43 216592011683 HMMPfam hit to PF01590, GAF domain, score 0.00062 216592011684 6 probable transmembrane helices predicted for EC042_2359 by TMHMM2.0 at aa 15-37, 49-68, 78-100, 112-134, 144-166 and 173-195 216592011685 HMMPfam hit to PF07694, 5TMR of 5TMR-LYT, score 2.7e-41 216592011686 transcriptional regulator MirA; Provisional; Region: PRK15043 216592011687 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 216592011688 DNA binding residues [nucleotide binding] 216592011689 Predicted helix-turn-helix motif with score 1630.000, SD 4.74 at aa 4-25, sequence YTIGEVALLCDINPVTLRAWQR 216592011690 HMMPfam hit to PF00376, MerR family regulatory protein, score 2.2e-11 216592011691 PS00552 Bacterial regulatory proteins, merR family signature. 216592011692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216592011693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592011694 dimer interface [polypeptide binding]; other site 216592011695 conserved gate region; other site 216592011696 putative PBP binding loops; other site 216592011697 ABC-ATPase subunit interface; other site 216592011698 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-32 216592011699 6 probable transmembrane helices predicted for EC042_2361 by TMHMM2.0 at aa 7-29, 49-71, 92-114, 118-140, 164-186 and 201-223 216592011700 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592011701 Signal peptide predicted for EC042_2361 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 30 and 31 216592011702 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216592011703 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 216592011704 Walker A/P-loop; other site 216592011705 ATP binding site [chemical binding]; other site 216592011706 Q-loop/lid; other site 216592011707 ABC transporter signature motif; other site 216592011708 Walker B; other site 216592011709 D-loop; other site 216592011710 H-loop/switch region; other site 216592011711 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 216592011712 HMMPfam hit to PF00005, ABC transporter, score 1.3e-59 216592011713 PS00211 ABC transporters family signature. 216592011714 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592011716 dimer interface [polypeptide binding]; other site 216592011717 conserved gate region; other site 216592011718 ABC-ATPase subunit interface; other site 216592011719 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.5e-31 216592011720 10 probable transmembrane helices predicted for EC042_2363 by TMHMM2.0 at aa 7-29, 44-66, 71-90, 100-122, 135-157, 182-204, 211-233, 248-270, 324-346 and 356-378 216592011721 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592011722 Signal peptide predicted for EC042_2363 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.456 between residues 22 and 23 216592011723 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216592011724 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 2.7e-90 216592011725 Signal peptide predicted for EC042_2364 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 23 and 24 216592011726 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 216592011727 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 216592011728 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 216592011729 HMMPfam hit to PF01915, Glycosyl hydrolase family 3 C termina, score 2.2e-101 216592011730 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N termina, score 5.3e-108 216592011731 PS00775 Glycosyl hydrolases family 3 active site. 216592011732 Signal peptide predicted for EC042_2365 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 20 and 21 216592011733 D-lactate dehydrogenase; Provisional; Region: PRK11183 216592011734 FAD binding domain; Region: FAD_binding_4; pfam01565 216592011735 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 216592011736 HMMPfam hit to PF01565, FAD binding domain, score 9.5e-20 216592011737 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216592011738 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 216592011739 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216592011740 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 1.7e-127 216592011741 Signal peptide predicted for EC042_2367 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.971 between residues 28 and 29 216592011742 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 216592011743 HMMPfam hit to PF06930, Protein of unknown function (DUF1282), score 2e-139 216592011744 5 probable transmembrane helices predicted for EC042_2368 by TMHMM2.0 at aa 41-63, 73-95, 116-138, 143-165 and 178-200 216592011745 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216592011746 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216592011747 HMMPfam hit to PF00597, DedA family, score 6e-55 216592011748 3 probable transmembrane helices predicted for EC042_2369 by TMHMM2.0 at aa 70-92, 160-182 and 192-209 216592011749 oxidoreductase; Provisional; Region: PRK12743 216592011750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216592011751 NAD(P) binding site [chemical binding]; other site 216592011752 active site 216592011753 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.2e-70 216592011754 PS00061 Short-chain dehydrogenases/reductases family signature. 216592011755 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 216592011756 HMMPfam hit to PF02321, Outer membrane efflux protein, score 6.9e-40 216592011757 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.7e-17 216592011758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592011759 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 216592011760 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216592011761 FMN binding site [chemical binding]; other site 216592011762 active site 216592011763 catalytic residues [active] 216592011764 substrate binding site [chemical binding]; other site 216592011765 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 4.3e-143 216592011766 PS01136 Uncharacterized protein family UPF0034 signature. 216592011767 hypothetical protein; Provisional; Region: PRK01821 216592011768 Signal peptide predicted for EC042_2373 by SignalP 2.0 HMM (Signal peptide probability 0.640) with cleavage site probability 0.507 between residues 32 and 33 216592011769 4 probable transmembrane helices predicted for EC042_2373 by TMHMM2.0 at aa 12-34, 38-60, 67-89 and 94-116 216592011770 HMMPfam hit to PF03788, LrgA family, score 7.1e-57 216592011771 hypothetical protein; Provisional; Region: PRK10711 216592011772 6 probable transmembrane helices predicted for EC042_2374 by TMHMM2.0 at aa 5-23, 30-52, 90-112, 119-141, 145-167 and 206-228 216592011773 HMMPfam hit to PF04172, LrgB-like family, score 4e-125 216592011774 cytidine deaminase; Provisional; Region: PRK09027 216592011775 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 216592011776 active site 216592011777 catalytic motif [active] 216592011778 Zn binding site [ion binding]; other site 216592011779 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 216592011780 active site 216592011781 catalytic motif [active] 216592011782 Zn binding site [ion binding]; other site 216592011783 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 2.7e-22 216592011784 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216592011785 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216592011786 putative active site [active] 216592011787 Signal peptide predicted for EC042_2376 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.915 between residues 22 and 23 216592011788 1 probable transmembrane helix predicted for EC042_2376 by TMHMM2.0 at aa 5-27 216592011789 HMMPfam hit to PF02698, DUF218 domain, score 4.4e-40 216592011790 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 216592011791 2 probable transmembrane helices predicted for EC042_2377 by TMHMM2.0 at aa 7-24 and 55-77 216592011792 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 216592011793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216592011794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592011795 PS00190 Cytochrome c family heme-binding site signature. 216592011796 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 5.7e-33 216592011798 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00056 216592011799 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.5e-05 216592011800 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592011801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592011802 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592011803 TM-ABC transporter signature motif; other site 216592011804 9 probable transmembrane helices predicted for EC042_2381 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149, 179-201, 222-244, 259-281, 286-308 and 312-330 216592011805 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 3.1e-64 216592011806 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592011807 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 216592011808 Walker A/P-loop; other site 216592011809 ATP binding site [chemical binding]; other site 216592011810 Q-loop/lid; other site 216592011811 ABC transporter signature motif; other site 216592011812 Walker B; other site 216592011813 D-loop; other site 216592011814 H-loop/switch region; other site 216592011815 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592011816 HMMPfam hit to PF00005, ABC transporter, score 2.3e-17 216592011817 PS00211 ABC transporters family signature. 216592011818 HMMPfam hit to PF00005, ABC transporter, score 2.2e-48 216592011819 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011820 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 216592011821 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 216592011822 ligand binding site [chemical binding]; other site 216592011823 calcium binding site [ion binding]; other site 216592011824 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.014 216592011825 1 probable transmembrane helix predicted for EC042_2383 by TMHMM2.0 at aa 5-24 216592011826 Signal peptide predicted for EC042_2383 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 23 and 24 216592011827 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 216592011828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592011829 DNA binding site [nucleotide binding] 216592011830 domain linker motif; other site 216592011831 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 216592011832 dimerization interface (closed form) [polypeptide binding]; other site 216592011833 ligand binding site [chemical binding]; other site 216592011834 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.1e-06 216592011835 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.1e-11 216592011836 Predicted helix-turn-helix motif with score 2365.000, SD 7.24 at aa 4-25, sequence ITIRDVARQAGVSVATVSRVLN 216592011837 PS00356 Bacterial regulatory proteins, lacI family signature. 216592011838 Predicted membrane protein [Function unknown]; Region: COG2311 216592011839 hypothetical protein; Provisional; Region: PRK10835 216592011840 HMMPfam hit to PF04235, Protein of unknown function (DUF418), score 3.4e-70 216592011841 10 probable transmembrane helices predicted for EC042_2385 by TMHMM2.0 at aa 12-34, 49-71, 83-102, 107-123, 130-152, 199-221, 234-253, 273-295, 308-327 and 337-359 216592011842 HMMPfam hit to PF04171, Protein of unknown function (DUF405), score 1.8e-66 216592011843 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 216592011844 homodecamer interface [polypeptide binding]; other site 216592011845 GTP cyclohydrolase I; Provisional; Region: PLN03044 216592011846 active site 216592011847 putative catalytic site residues [active] 216592011848 zinc binding site [ion binding]; other site 216592011849 GTP-CH-I/GFRP interaction surface; other site 216592011850 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 4.7e-55 216592011851 PS00860 GTP cyclohydrolase I signature 2. 216592011852 PS00859 GTP cyclohydrolase I signature 1. 216592011853 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 216592011854 S-formylglutathione hydrolase; Region: PLN02442 216592011855 HMMPfam hit to PF00756, Putative esterase, score 1.6e-118 216592011856 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 216592011857 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592011858 N-terminal plug; other site 216592011859 ligand-binding site [chemical binding]; other site 216592011860 HMMPfam hit to PF00593, TonB dependent receptor, score 3.4e-30 216592011861 PS01156 TonB-dependent receptor proteins signature 2. 216592011862 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.1e-33 216592011863 PS00430 TonB-dependent receptor proteins signature 1. 216592011864 lysine transporter; Provisional; Region: PRK10836 216592011865 HMMPfam hit to PF00324, Amino acid permease, score 3e-205 216592011866 12 probable transmembrane helices predicted for EC042_2389 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 370-392, 413-435 and 445-467 216592011867 PS00218 Amino acid permeases signature. 216592011868 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 216592011869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592011870 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 216592011871 putative dimerization interface [polypeptide binding]; other site 216592011872 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-59 216592011873 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-17 216592011874 PS00044 Bacterial regulatory proteins, lysR family signature. 216592011875 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 18-39, sequence GSTTQASVMLALSQSAVSAALT 216592011876 conserved hypothetical integral membrane protein; Region: TIGR00698 216592011877 Signal peptide predicted for EC042_2391 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.645 between residues 40 and 41 216592011878 8 probable transmembrane helices predicted for EC042_2391 by TMHMM2.0 at aa 13-32, 36-58, 100-122, 132-151, 163-185, 262-283, 290-312 and 322-344 216592011879 HMMPfam hit to PF03601, Conserved hypothetical protein, score 9.4e-176 216592011880 endonuclease IV; Provisional; Region: PRK01060 216592011881 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 216592011882 AP (apurinic/apyrimidinic) site pocket; other site 216592011883 DNA interaction; other site 216592011884 Metal-binding active site; metal-binding site 216592011885 Signal peptide predicted for EC042_2392 by SignalP 2.0 HMM (Signal peptide probability 0.634) with cleavage site probability 0.299 between residues 21 and 22 216592011886 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.8e-64 216592011887 PS00729 AP endonucleases family 2 signature 1. 216592011888 PS00730 AP endonucleases family 2 signature 2. 216592011889 PS00731 AP endonucleases family 2 signature 3. 216592011890 putative kinase; Provisional; Region: PRK09954 216592011891 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216592011892 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 216592011893 substrate binding site [chemical binding]; other site 216592011894 ATP binding site [chemical binding]; other site 216592011895 Predicted helix-turn-helix motif with score 1298.000, SD 3.61 at aa 18-39, sequence IQQNEIADMLQISRSRVAAHIM 216592011896 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.1e-66 216592011897 PS00583 pfkB family of carbohydrate kinases signature 1. 216592011898 PS00584 pfkB family of carbohydrate kinases signature 2. 216592011899 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 216592011900 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 216592011901 Nucleoside recognition; Region: Gate; pfam07670 216592011902 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 216592011903 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 1.5e-101 216592011904 8 probable transmembrane helices predicted for EC042_2394 by TMHMM2.0 at aa 5-22, 27-49, 96-118, 173-195, 199-221, 258-280, 355-377 and 390-412 216592011905 HMMPfam hit to PF07670, Nucleoside recognition, score 1.3e-11 216592011906 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 2.9e-34 216592011907 Signal peptide predicted for EC042_2394 by SignalP 2.0 HMM (Signal peptide probability 0.650) with cleavage site probability 0.331 between residues 24 and 25 216592011908 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216592011909 active site 216592011910 tetramer interface [polypeptide binding]; other site 216592011911 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 5.4e-187 216592011912 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 216592011913 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 216592011914 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216592011915 ligand binding site [chemical binding]; other site 216592011916 flexible hinge region; other site 216592011917 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 216592011918 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.2e-09 216592011919 Predicted helix-turn-helix motif with score 1127.000, SD 3.03 at aa 170-191, sequence EKHTQAAEYLGVSYRHLLYVLA 216592011920 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 216592011921 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 216592011922 Nucleoside recognition; Region: Gate; pfam07670 216592011923 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 216592011924 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 9.5e-98 216592011925 8 probable transmembrane helices predicted for EC042_2397 by TMHMM2.0 at aa 5-22, 27-49, 96-118, 173-195, 258-280, 287-309, 355-377 and 390-412 216592011926 HMMPfam hit to PF07670, Nucleoside recognition, score 9.9e-13 216592011927 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 3e-34 216592011928 Signal peptide predicted for EC042_2397 by SignalP 2.0 HMM (Signal peptide probability 0.798) with cleavage site probability 0.525 between residues 24 and 25 216592011929 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 216592011930 HMMPfam hit to PF04227, Indigoidine synthase A like protein, score 8.3e-224 216592011931 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 216592011932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592011933 substrate binding site [chemical binding]; other site 216592011934 ATP binding site [chemical binding]; other site 216592011935 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.6e-68 216592011936 PS00584 pfkB family of carbohydrate kinases signature 2. 216592011937 PS00583 pfkB family of carbohydrate kinases signature 1. 216592011938 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 216592011939 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 216592011940 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 216592011941 active site 216592011942 P-loop; other site 216592011943 phosphorylation site [posttranslational modification] 216592011944 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 216592011945 9 probable transmembrane helices predicted for EC042_2400 by TMHMM2.0 at aa 237-259, 272-294, 304-326, 346-368, 378-400, 413-435, 465-482, 489-509 and 529-551 216592011946 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9.9e-67 216592011947 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 3.2e-63 216592011948 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 216592011949 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 216592011950 putative substrate binding site [chemical binding]; other site 216592011951 putative ATP binding site [chemical binding]; other site 216592011952 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 7.3e-69 216592011953 PS00584 pfkB family of carbohydrate kinases signature 2. 216592011954 PS00583 pfkB family of carbohydrate kinases signature 1. 216592011955 PS00464 Ribosomal protein L22 signature. 216592011956 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 216592011957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592011958 active site 216592011959 phosphorylation site [posttranslational modification] 216592011960 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592011961 dimerization domain swap beta strand [polypeptide binding]; other site 216592011962 regulatory protein interface [polypeptide binding]; other site 216592011963 active site 216592011964 regulatory phosphorylation site [posttranslational modification]; other site 216592011965 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.6e-50 216592011966 PS00589 PTS HPR component serine phosphorylation site signature. 216592011967 PS00369 PTS HPR component histidine phosphorylation site signature. 216592011968 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 2.9e-78 216592011969 PS00372 PTS EIIA domains phosphorylation site signature 2. 216592011970 sugar efflux transporter B; Provisional; Region: PRK15011 216592011971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592011972 putative substrate translocation pore; other site 216592011973 Signal peptide predicted for EC042_2403 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.858 between residues 32 and 33 216592011974 12 probable transmembrane helices predicted for EC042_2403 by TMHMM2.0 at aa 13-35, 50-72, 84-101, 105-124, 145-167, 172-194, 222-244, 254-276, 283-302, 307-329, 350-367 and 371-388 216592011975 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.4e-42 216592011976 elongation factor P; Provisional; Region: PRK04542 216592011977 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216592011978 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 216592011979 RNA binding site [nucleotide binding]; other site 216592011980 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 216592011981 RNA binding site [nucleotide binding]; other site 216592011982 HMMPfam hit to PF01132, Elongation factor P (EF-P), score 1.1e-116 216592011983 PS01275 Elongation factor P signature. 216592011984 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216592011985 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216592011986 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216592011987 HMMPfam hit to PF01232, Mannitol dehydrogenase, score 9.9e-256 216592011988 PS00974 Mannitol dehydrogenases signature. 216592011989 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216592011990 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 216592011991 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 216592011992 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 6.3e-46 216592011993 PS00017 ATP/GTP-binding site motif A (P-loop). 216592011994 HMMPfam hit to PF07683, Cobalamin synthesis protein cobW C-terminal, score 2.4e-09 216592011995 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216592011996 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 216592011997 active site 216592011998 5 probable transmembrane helices predicted for EC042_2407 by TMHMM2.0 at aa 21-43, 74-93, 105-127, 172-194 and 207-224 216592011999 HMMPfam hit to PF01569, PAP2 superfamily, score 1.4e-20 216592012000 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 216592012001 NlpC/P60 family; Region: NLPC_P60; pfam00877 216592012002 Signal peptide predicted for EC042_2408 by SignalP 2.0 HMM (Signal peptide probability 0.987) with cleavage site probability 0.335 between residues 29 and 30 216592012003 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592012004 HMMPfam hit to PF00877, NlpC/P60 family, score 4.1e-56 216592012005 phage resistance protein; Provisional; Region: PRK10551 216592012006 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216592012007 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592012008 Signal peptide predicted for EC042_2409 by SignalP 2.0 HMM (Signal peptide probability 0.716) with cleavage site probability 0.382 between residues 34 and 35 216592012009 2 probable transmembrane helices predicted for EC042_2409 by TMHMM2.0 at aa 12-34 and 236-258 216592012010 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592012011 HMMPfam hit to PF00563, EAL domain, score 7.5e-102 216592012012 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216592012013 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216592012014 Signal peptide predicted for EC042_2410 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.921 between residues 21 and 22 216592012015 1 probable transmembrane helix predicted for EC042_2410 by TMHMM2.0 at aa 7-24 216592012016 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 9e-53 216592012017 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 216592012018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592012019 dimer interface [polypeptide binding]; other site 216592012020 conserved gate region; other site 216592012021 putative PBP binding loops; other site 216592012022 ABC-ATPase subunit interface; other site 216592012023 6 probable transmembrane helices predicted for EC042_2411 by TMHMM2.0 at aa 9-31, 134-156, 169-191, 224-246, 283-305 and 329-348 216592012024 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-59 216592012025 microcin C ABC transporter permease; Provisional; Region: PRK15021 216592012026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592012027 dimer interface [polypeptide binding]; other site 216592012028 conserved gate region; other site 216592012029 ABC-ATPase subunit interface; other site 216592012030 Signal peptide predicted for EC042_2412 by SignalP 2.0 HMM (Signal peptide probability 0.949) with cleavage site probability 0.937 between residues 42 and 43 216592012031 6 probable transmembrane helices predicted for EC042_2412 by TMHMM2.0 at aa 21-43, 142-164, 177-199, 203-222, 254-276 and 306-328 216592012032 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.3e-47 216592012033 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592012034 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 216592012035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592012036 Walker A/P-loop; other site 216592012037 ATP binding site [chemical binding]; other site 216592012038 Q-loop/lid; other site 216592012039 ABC transporter signature motif; other site 216592012040 Walker B; other site 216592012041 D-loop; other site 216592012042 H-loop/switch region; other site 216592012043 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592012044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592012045 Walker A/P-loop; other site 216592012046 ATP binding site [chemical binding]; other site 216592012047 Q-loop/lid; other site 216592012048 ABC transporter signature motif; other site 216592012049 Walker B; other site 216592012050 D-loop; other site 216592012051 H-loop/switch region; other site 216592012052 HMMPfam hit to PF00005, ABC transporter, score 1.7e-57 216592012053 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012054 PS00211 ABC transporters family signature. 216592012055 HMMPfam hit to PF00005, ABC transporter, score 6.9e-59 216592012056 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012057 PS00211 ABC transporters family signature. 216592012058 hypothetical protein; Provisional; Region: PRK11835 216592012059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592012060 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 216592012061 putative substrate translocation pore; other site 216592012062 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00015 216592012063 12 probable transmembrane helices predicted for EC042_2415 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-305, 310-332, 344-366 and 370-389 216592012064 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-54 216592012065 Signal peptide predicted for EC042_2415 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.868 between residues 37 and 38 216592012066 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 216592012067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592012068 RNA binding surface [nucleotide binding]; other site 216592012069 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 216592012070 active site 216592012071 uracil binding [chemical binding]; other site 216592012072 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.2e-29 216592012073 PS01149 Rsu family of pseudouridine synthase signature. 216592012074 HMMPfam hit to PF01479, S4 domain, score 1.4e-10 216592012075 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216592012076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592012077 ATP binding site [chemical binding]; other site 216592012078 putative Mg++ binding site [ion binding]; other site 216592012079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592012080 nucleotide binding region [chemical binding]; other site 216592012081 ATP-binding site [chemical binding]; other site 216592012082 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 216592012083 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3.2e-43 216592012084 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 5.2e-17 216592012085 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.4e-13 216592012086 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012087 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 216592012088 5S rRNA interface [nucleotide binding]; other site 216592012089 CTC domain interface [polypeptide binding]; other site 216592012090 L16 interface [polypeptide binding]; other site 216592012091 HMMPfam hit to PF01386, Ribosomal L25p family, score 2.1e-50 216592012092 Nucleoid-associated protein [General function prediction only]; Region: COG3081 216592012093 nucleoid-associated protein NdpA; Validated; Region: PRK00378 216592012094 HMMPfam hit to PF04245, 37-kD nucleoid-associated bacterial protein, score 7.1e-173 216592012095 hypothetical protein; Provisional; Region: PRK13689 216592012096 HMMPfam hit to PF07208, Protein of unknown function (DUF1414), score 2.3e-51 216592012097 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 216592012098 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 216592012099 Sulfatase; Region: Sulfatase; pfam00884 216592012100 PS00430 TonB-dependent receptor proteins signature 1. 216592012101 5 probable transmembrane helices predicted for EC042_2421 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191 216592012102 HMMPfam hit to PF00884, Sulfatase, score 2.3e-94 216592012103 prophage-like. Unique to 042, misc. island, regulator similar to transcriptional activator of eaeA/bfpA expression in enteropathogenic E.coli, proQ, structural element that influences the osmotic activation of proP at a posttranslational level), possible prophage fragment, inserted next to tRNA, no repeat flanking island 216592012104 integrase; Provisional; Region: PRK09692 216592012105 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592012106 active site 216592012107 Int/Topo IB signature motif; other site 216592012108 HMMPfam hit to PF00589, Phage integrase family, score 1.7e-32 216592012109 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 216592012110 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 8.9e-08 216592012111 Ash protein family; Region: Phage_ASH; pfam10554 216592012112 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592012113 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012114 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 216592012115 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216592012116 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592012117 ssDNA binding site [nucleotide binding]; other site 216592012118 dimer interface [polypeptide binding]; other site 216592012119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592012120 HMMPfam hit to PF00436, Single-strand binding protein family, score 3.3e-10 216592012121 putative RNA binding sites [nucleotide binding]; other site 216592012122 ProQ/FINO family; Region: ProQ; pfam04352 216592012123 PerC transcriptional activator; Region: PerC; pfam06069 216592012124 HMMPfam hit to PF06069, PerC transcriptional activator, score 2.3e-38 216592012125 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592012126 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 216592012127 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592012128 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592012129 HMMPfam hit to PF03797, Autotransporter beta-domain, score 8.5e-34 216592012130 HMMPfam hit to PF03212, Pertactin, score 7.1e-73 216592012131 Signal peptide predicted for EC042_2433 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.994 between residues 29 and 30 216592012132 transcriptional regulator NarP; Provisional; Region: PRK10403 216592012133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592012134 active site 216592012135 phosphorylation site [posttranslational modification] 216592012136 intermolecular recognition site; other site 216592012137 dimerization interface [polypeptide binding]; other site 216592012138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592012139 DNA binding residues [nucleotide binding] 216592012140 dimerization interface [polypeptide binding]; other site 216592012141 HMMPfam hit to PF00072, Response regulator receiver domain, score 1e-46 216592012142 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.9e-30 216592012143 PS00622 Bacterial regulatory proteins, luxR family signature. 216592012144 Predicted helix-turn-helix motif with score 1668.000, SD 4.87 at aa 179-200, sequence LSNKQIASVLNISEQTVKVHIR 216592012145 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 216592012146 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 216592012147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592012148 binding surface 216592012149 TPR motif; other site 216592012150 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.014 216592012151 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.041 216592012152 3 probable transmembrane helices predicted for EC042_2435 by TMHMM2.0 at aa 3-25, 97-119 and 147-169 216592012153 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 6.6e-100 216592012154 Signal peptide predicted for EC042_2435 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 18 and 19 216592012155 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 216592012156 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 216592012157 catalytic residues [active] 216592012158 central insert; other site 216592012159 PS00194 Thioredoxin family active site. 216592012160 Signal peptide predicted for EC042_2436 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.371 between residues 30 and 31 216592012161 1 probable transmembrane helix predicted for EC042_2436 by TMHMM2.0 at aa 5-24 216592012162 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 216592012163 15 probable transmembrane helices predicted for EC042_2437 by TMHMM2.0 at aa 10-29, 41-63, 95-114, 121-143, 176-198, 211-233, 248-265, 272-294, 309-331, 351-373, 393-415, 422-444, 448-470, 482-504 and 610-629 216592012164 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1.9e-89 216592012165 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 216592012166 HMMPfam hit to PF03100, CcmE, score 6.1e-94 216592012167 Signal peptide predicted for EC042_2438 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.562 between residues 29 and 30 216592012168 1 probable transmembrane helix predicted for EC042_2438 by TMHMM2.0 at aa 7-29 216592012169 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 216592012170 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 8.6e-20 216592012171 1 probable transmembrane helix predicted for EC042_2439 by TMHMM2.0 at aa 15-37 216592012172 heme exporter protein CcmC; Region: ccmC; TIGR01191 216592012173 6 probable transmembrane helices predicted for EC042_2440 by TMHMM2.0 at aa 27-49, 69-91, 98-120, 135-157, 162-184 and 212-234 216592012174 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1.3e-61 216592012175 heme exporter protein CcmB; Region: ccmB; TIGR01190 216592012176 HMMPfam hit to PF03379, CcmB protein, score 9.7e-129 216592012177 6 probable transmembrane helices predicted for EC042_2441 by TMHMM2.0 at aa 21-40, 44-66, 97-119, 129-151, 158-180 and 195-217 216592012178 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 216592012179 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 216592012180 Walker A/P-loop; other site 216592012181 ATP binding site [chemical binding]; other site 216592012182 Q-loop/lid; other site 216592012183 ABC transporter signature motif; other site 216592012184 Walker B; other site 216592012185 D-loop; other site 216592012186 H-loop/switch region; other site 216592012187 HMMPfam hit to PF00005, ABC transporter, score 3.8e-55 216592012188 PS00211 ABC transporters family signature. 216592012189 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012190 cytochrome c-type protein NapC; Provisional; Region: PRK10617 216592012191 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 216592012192 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 2.3e-128 216592012193 PS00190 Cytochrome c family heme-binding site signature. 216592012194 PS00190 Cytochrome c family heme-binding site signature. 216592012195 PS00190 Cytochrome c family heme-binding site signature. 216592012196 Signal peptide predicted for EC042_2443 by SignalP 2.0 HMM (Signal peptide probability 0.702) with cleavage site probability 0.404 between residues 51 and 52 216592012197 1 probable transmembrane helix predicted for EC042_2443 by TMHMM2.0 at aa 21-43 216592012198 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 216592012199 HMMPfam hit to PF03892, Nitrate reductase cytochrome c-type subunit, score 1.1e-51 216592012200 PS00190 Cytochrome c family heme-binding site signature. 216592012201 PS00190 Cytochrome c family heme-binding site signature. 216592012202 Signal peptide predicted for EC042_2444 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.977 between residues 34 and 35 216592012203 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 216592012204 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216592012205 4Fe-4S binding domain; Region: Fer4_6; pfam12837 216592012206 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0004 216592012207 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012208 4 probable transmembrane helices predicted for EC042_2445 by TMHMM2.0 at aa 30-52, 78-100, 138-160 and 170-192 216592012209 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 216592012210 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.002 216592012211 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.8e-05 216592012212 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012213 Signal peptide predicted for EC042_2446 by SignalP 2.0 HMM (Signal peptide probability 0.837) with cleavage site probability 0.354 between residues 36 and 37 216592012214 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 216592012215 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 216592012216 [4Fe-4S] binding site [ion binding]; other site 216592012217 molybdopterin cofactor binding site; other site 216592012218 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 216592012219 molybdopterin cofactor binding site; other site 216592012220 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.1e-43 216592012221 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.6e-137 216592012222 Predicted helix-turn-helix motif with score 1025.000, SD 2.68 at aa 336-357, sequence YTLEKTAEMTGVPKDQLEQLAQ 216592012223 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 2.2e-23 216592012224 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592012225 Signal peptide predicted for EC042_2447 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.909 between residues 31 and 32 216592012226 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 216592012227 HMMPfam hit to PF03927, NapD protein, score 2.1e-41 216592012228 ferredoxin-type protein; Provisional; Region: PRK10194 216592012229 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 3.7e-07 216592012230 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012231 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00083 216592012232 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012233 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.001 216592012234 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012235 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 216592012236 secondary substrate binding site; other site 216592012237 primary substrate binding site; other site 216592012238 inhibition loop; other site 216592012239 dimerization interface [polypeptide binding]; other site 216592012240 HMMPfam hit to PF03974, Ecotin, score 3.3e-144 216592012241 Signal peptide predicted for EC042_2450 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 20 and 21 216592012242 malate:quinone oxidoreductase; Validated; Region: PRK05257 216592012243 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 216592012244 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 0 216592012245 Signal peptide predicted for EC042_2451 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.626 between residues 21 and 22 216592012246 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 216592012247 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 216592012248 Walker A/P-loop; other site 216592012249 ATP binding site [chemical binding]; other site 216592012250 Q-loop/lid; other site 216592012251 ABC transporter signature motif; other site 216592012252 Walker B; other site 216592012253 D-loop; other site 216592012254 H-loop/switch region; other site 216592012255 HMMPfam hit to PF00005, ABC transporter, score 5.5e-42 216592012256 PS00211 ABC transporters family signature. 216592012257 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012258 6 probable transmembrane helices predicted for EC042_2452 by TMHMM2.0 at aa 13-35, 50-72, 122-144, 149-171, 231-253 and 268-290 216592012259 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.0088 216592012260 Signal peptide predicted for EC042_2452 by SignalP 2.0 HMM (Signal peptide probability 0.797) with cleavage site probability 0.459 between residues 29 and 30 216592012261 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 216592012262 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 1.9e-07 216592012263 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 216592012264 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 216592012265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592012266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592012267 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 216592012268 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216592012269 DNA binding site [nucleotide binding] 216592012270 active site 216592012271 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 3.2e-58 216592012272 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 216592012273 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 2.4e-25 216592012274 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 1.1e-05 216592012275 PS00041 Bacterial regulatory proteins, araC family signature. 216592012276 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix, score 2.8e-14 216592012277 PS00041 Bacterial regulatory proteins, araC family signature. 216592012278 Predicted helix-turn-helix motif with score 1595.000, SD 4.62 at aa 100-121, sequence VTLEALADQVAMSPFHLHRLFK 216592012279 HMMPfam hit to PF02805, Metal binding domain of Ada, score 1.5e-46 216592012280 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 216592012281 ApbE family; Region: ApbE; pfam02424 216592012282 HMMPfam hit to PF02424, ApbE family, score 1e-169 216592012283 Signal peptide predicted for EC042_2455 by SignalP 2.0 HMM (Signal peptide probability 0.797) with cleavage site probability 0.339 between residues 31 and 32 216592012284 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592012285 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 216592012286 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 216592012287 trimer interface [polypeptide binding]; other site 216592012288 eyelet of channel; other site 216592012289 HMMPfam hit to PF00267, Gram-negative porin, score 2.2e-200 216592012290 PS00576 General diffusion Gram-negative porins signature. 216592012291 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592012292 Signal peptide predicted for EC042_2456 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592012293 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 216592012294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592012295 ATP binding site [chemical binding]; other site 216592012296 G-X-G motif; other site 216592012297 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216592012298 putative binding surface; other site 216592012299 active site 216592012300 Signal peptide predicted for EC042_2457 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.483 between residues 40 and 41 216592012301 1 probable transmembrane helix predicted for EC042_2457 by TMHMM2.0 at aa 21-43 216592012302 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.2e-12 216592012303 HMMPfam hit to PF01627, Hpt domain, score 4.1e-15 216592012304 transcriptional regulator RcsB; Provisional; Region: PRK10840 216592012305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592012306 active site 216592012307 phosphorylation site [posttranslational modification] 216592012308 intermolecular recognition site; other site 216592012309 dimerization interface [polypeptide binding]; other site 216592012310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592012311 DNA binding residues [nucleotide binding] 216592012312 dimerization interface [polypeptide binding]; other site 216592012313 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-32 216592012314 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.4e-21 216592012315 PS00622 Bacterial regulatory proteins, luxR family signature. 216592012316 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 181-202, sequence FLVTEIAKKLNRSIKTISSQKK 216592012317 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 216592012318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592012319 dimer interface [polypeptide binding]; other site 216592012320 phosphorylation site [posttranslational modification] 216592012321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592012322 ATP binding site [chemical binding]; other site 216592012323 Mg2+ binding site [ion binding]; other site 216592012324 G-X-G motif; other site 216592012325 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 216592012326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592012327 active site 216592012328 phosphorylation site [posttranslational modification] 216592012329 intermolecular recognition site; other site 216592012330 dimerization interface [polypeptide binding]; other site 216592012331 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.8e-41 216592012332 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 5.5e-45 216592012333 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-21 216592012334 2 probable transmembrane helices predicted for EC042_2459 by TMHMM2.0 at aa 20-42 and 315-334 216592012335 Signal peptide predicted for EC042_2459 by SignalP 2.0 HMM (Signal peptide probability 0.989) with cleavage site probability 0.609 between residues 32 and 33 216592012336 Present in Uropathogenic, absent in 0157, fatty acid utilization operon (regulators, transporter and transferases) 216592012337 sensory histidine kinase AtoS; Provisional; Region: PRK11360 216592012338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592012339 putative active site [active] 216592012340 heme pocket [chemical binding]; other site 216592012341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592012342 dimer interface [polypeptide binding]; other site 216592012343 phosphorylation site [posttranslational modification] 216592012344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592012345 ATP binding site [chemical binding]; other site 216592012346 Mg2+ binding site [ion binding]; other site 216592012347 G-X-G motif; other site 216592012348 2 probable transmembrane helices predicted for EC042_2460 by TMHMM2.0 at aa 20-39 and 196-215 216592012349 HMMPfam hit to PF00672, HAMP domain, score 2.9e-10 216592012350 HMMPfam hit to PF00989, PAS domain, score 2.2e-15 216592012351 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.5e-19 216592012352 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1e-35 216592012353 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 216592012354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592012355 active site 216592012356 phosphorylation site [posttranslational modification] 216592012357 intermolecular recognition site; other site 216592012358 dimerization interface [polypeptide binding]; other site 216592012359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592012360 Walker A motif; other site 216592012361 ATP binding site [chemical binding]; other site 216592012362 Walker B motif; other site 216592012363 arginine finger; other site 216592012364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592012365 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-39 216592012366 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.8e-158 216592012367 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592012368 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592012369 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592012370 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2.5e-15 216592012371 Predicted helix-turn-helix motif with score 1523.000, SD 4.37 at aa 431-452, sequence GNRTRTALMLGISRRALMYKLQ 216592012372 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 216592012373 HMMPfam hit to PF01144, Coenzyme A transferase, score 9.5e-95 216592012374 PS01273 CoA transferases signature 1. 216592012375 Predicted helix-turn-helix motif with score 1018.000, SD 2.65 at aa 69-90, sequence RVRKVIASHIGTNPETGRRMIS 216592012376 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 216592012377 HMMPfam hit to PF01144, Coenzyme A transferase, score 1.5e-65 216592012378 PS01274 CoA transferases signature 2. 216592012379 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 216592012380 HMMPfam hit to PF02667, Short chain fatty acid transporter, score 0 216592012381 Signal peptide predicted for EC042_2464 by SignalP 2.0 HMM (Signal peptide probability 0.845) with cleavage site probability 0.674 between residues 35 and 36 216592012382 9 probable transmembrane helices predicted for EC042_2464 by TMHMM2.0 at aa 20-40, 53-75, 95-117, 138-160, 175-197, 245-262, 266-285, 298-320 and 417-439 216592012383 putative acyltransferase; Provisional; Region: PRK05790 216592012384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216592012385 dimer interface [polypeptide binding]; other site 216592012386 active site 216592012387 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 4.3e-162 216592012388 Signal peptide predicted for EC042_2465 by SignalP 2.0 HMM (Signal peptide probability 0.884) with cleavage site probability 0.651 between residues 22 and 23 216592012389 PS00098 Thiolases acyl-enzyme intermediate signature. 216592012390 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1.4e-79 216592012391 PS00737 Thiolases signature 2. 216592012392 PS00099 Thiolases active site. 216592012393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 216592012394 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 216592012395 Signal peptide predicted for EC042_2466 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 19 and 20 216592012396 Predicted secreted protein [Function unknown]; Region: COG5445 216592012397 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 216592012398 Predicted secreted protein [Function unknown]; Region: COG5445 216592012399 Stage II sporulation protein; Region: SpoIID; pfam08486 216592012400 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 216592012401 Signal peptide predicted for EC042_2467 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 216592012402 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 216592012403 MG2 domain; Region: A2M_N; pfam01835 216592012404 Alpha-2-macroglobulin family; Region: A2M; pfam00207 216592012405 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 216592012406 HMMPfam hit to PF07703, Alpha-2-macroglobulin family N-terminal regi, score 3.2e-23 216592012407 HMMPfam hit to PF01835, Alpha-2-macroglobulin family N-terminal regi, score 3.8e-61 216592012408 Signal peptide predicted for EC042_2468 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 38 and 39 216592012409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 216592012410 HMMPfam hit to PF06672, Protein of unknown function (DUF1175), score 2.4e-186 216592012411 Signal peptide predicted for EC042_2469 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.939 between residues 19 and 20 216592012412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 216592012413 1 probable transmembrane helix predicted for EC042_2470 by TMHMM2.0 at aa 12-34 216592012414 Signal peptide predicted for EC042_2470 by SignalP 2.0 HMM (Signal peptide probability 0.994) with cleavage site probability 0.976 between residues 30 and 31 216592012415 DNA gyrase subunit A; Validated; Region: PRK05560 216592012416 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216592012417 CAP-like domain; other site 216592012418 active site 216592012419 primary dimer interface [polypeptide binding]; other site 216592012420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012423 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012424 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012425 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592012426 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-13 216592012427 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.8e-14 216592012428 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.6e-16 216592012429 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 4.4e-09 216592012430 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 4.9e-15 216592012431 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-13 216592012432 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 216592012433 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 216592012434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592012435 S-adenosylmethionine binding site [chemical binding]; other site 216592012436 adhesin; Provisional; Region: PRK09752 216592012437 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592012438 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592012439 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3.6e-34 216592012440 HMMPfam hit to PF03212, Pertactin, score 0.00014 216592012441 HMMPfam hit to PF05594, no description, score 9.9 216592012442 HMMPfam hit to PF05594, no description, score 7.4 216592012443 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0077 216592012444 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.086 216592012445 HMMPfam hit to PF05594, no description, score 4.2 216592012446 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.1 216592012447 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0042 216592012448 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 7.3 216592012449 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 13 216592012450 Signal peptide predicted for EC042_2473 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.640 between residues 28 and 29 216592012451 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 216592012452 ATP cone domain; Region: ATP-cone; pfam03477 216592012453 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216592012454 active site 216592012455 dimer interface [polypeptide binding]; other site 216592012456 catalytic residues [active] 216592012457 effector binding site; other site 216592012458 R2 peptide binding site; other site 216592012459 HMMPfam hit to PF03477, ATP cone domain, score 2e-21 216592012460 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 8.2e-24 216592012461 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 3.9e-280 216592012462 PS00089 Ribonucleotide reductase large subunit signature. 216592012463 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216592012464 dimer interface [polypeptide binding]; other site 216592012465 putative radical transfer pathway; other site 216592012466 diiron center [ion binding]; other site 216592012467 tyrosyl radical; other site 216592012468 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 1.4e-174 216592012469 PS00368 Ribonucleotide reductase small subunit signature. 216592012470 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216592012471 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592012472 catalytic loop [active] 216592012473 iron binding site [ion binding]; other site 216592012474 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 2e-14 216592012475 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216592012476 hypothetical protein; Provisional; Region: PRK09902 216592012477 HMMPfam hit to PF06293, Lipopolysaccharide kinase (Kdo/WaaP) family, score 1e-99 216592012478 PS00213 Lipocalin signature. 216592012479 Present in 0157, absent in Uropathogenic, misc. islet (Major Facilitator Superfamily protein-pseudogene, regulator and hypothetical protein) 216592012481 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012482 3 probable transmembrane helices predicted for EC042_2478 by TMHMM2.0 at aa 3-25, 38-60 and 67-86 216592012483 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-16 216592012484 9 probable transmembrane helices predicted for EC042_2479 by TMHMM2.0 at aa 11-33, 46-65, 75-93, 100-117, 132-154, 166-188, 208-230, 243-262 and 272-290 216592012485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592012486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592012487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216592012488 dimerization interface [polypeptide binding]; other site 216592012489 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.9e-13 216592012490 Predicted helix-turn-helix motif with score 1726.000, SD 5.07 at aa 16-37, sequence GGFTEASKRLFMTQSAVSQAIA 216592012491 PS00044 Bacterial regulatory proteins, lysR family signature. 216592012492 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-09 216592012493 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 216592012494 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 216592012495 active site 216592012496 catalytic site [active] 216592012497 metal binding site [ion binding]; metal-binding site 216592012498 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 8.5e-114 216592012499 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012500 Signal peptide predicted for EC042_2482 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.999 between residues 44 and 45 216592012501 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 216592012502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592012503 putative substrate translocation pore; other site 216592012504 12 probable transmembrane helices predicted for EC042_2483 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 155-177, 187-206, 254-273, 293-312, 319-341, 351-373, 386-408 and 418-437 216592012505 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-49 216592012506 PS00942 glpT family of transporters signature. 216592012507 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 216592012508 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216592012509 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216592012510 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 5.2e-72 216592012511 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 216592012512 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 216592012513 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 1.6e-18 216592012514 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 216592012515 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 216592012516 HMMPfam hit to PF06982, Anaerobic glycerol-3-phosphate dehydrogenase, score 1.2e-270 216592012517 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 216592012518 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592012519 Cysteine-rich domain; Region: CCG; pfam02754 216592012520 Cysteine-rich domain; Region: CCG; pfam02754 216592012521 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012522 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.002 216592012523 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012524 HMMPfam hit to PF02754, Cysteine-rich domain, score 1.1e-09 216592012525 HMMPfam hit to PF02754, Cysteine-rich domain, score 8.9e-17 216592012526 hypothetical protein; Provisional; Region: PRK09956 216592012527 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 216592012528 HMMPfam hit to PF04754, Putative transposase, YhgA-like, score 4.5e-217 216592012529 hypothetical protein; Provisional; Region: PRK09956 216592012530 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 216592012531 HMMPfam hit to PF03328, HpcH/HpaI aldolase/citrate lyase family, score 7e-117 216592012533 11 probable transmembrane helices predicted for EC042_2490 by TMHMM2.0 at aa 31-53, 58-80, 86-108, 121-143, 153-175, 220-242, 252-274, 287-304, 308-330, 337-359 and 374-396 216592012534 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.2e-47 216592012535 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 216592012536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 216592012537 Probable transposase; Region: OrfB_IS605; pfam01385 216592012538 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 216592012539 HMMPfam hit to PF07282, Putative transposase DNA-binding domai, score 3.8e-34 216592012540 HMMPfam hit to PF01385, Probable transposase, score 1.3e-141 216592012541 hypothetical protein; Provisional; Region: PRK03673 216592012542 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 216592012543 putative MPT binding site; other site 216592012544 Competence-damaged protein; Region: CinA; cl00666 216592012545 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 3.3e-06 216592012546 YfaZ precursor; Region: YfaZ; pfam07437 216592012547 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 216592012548 HMMPfam hit to PF07437, YfaZ precursor, score 6.1e-130 216592012549 Signal peptide predicted for EC042_2493 by SignalP 2.0 HMM (Signal peptide probability 0.744) with cleavage site probability 0.703 between residues 21 and 22 216592012550 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 216592012551 HMMPfam hit to PF00293, NUDIX domain, score 1.3e-24 216592012552 PS00893 mutT domain signature. 216592012553 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 216592012554 catalytic core [active] 216592012555 2 probable transmembrane helices predicted for EC042_2495 by TMHMM2.0 at aa 5-24 and 33-52 216592012556 Signal peptide predicted for EC042_2495 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.609 between residues 50 and 51 216592012557 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216592012558 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216592012559 inhibitor-cofactor binding pocket; inhibition site 216592012560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592012561 catalytic residue [active] 216592012562 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 2.8e-194 216592012563 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216592012564 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216592012565 Ligand binding site; other site 216592012566 Putative Catalytic site; other site 216592012567 DXD motif; other site 216592012568 HMMPfam hit to PF00535, Glycosyl transferase, score 2.3e-34 216592012569 2 probable transmembrane helices predicted for EC042_2497 by TMHMM2.0 at aa 236-258 and 273-295 216592012570 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 216592012571 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 216592012572 substrate binding site [chemical binding]; other site 216592012573 cosubstrate binding site; other site 216592012574 catalytic site [active] 216592012575 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 216592012576 active site 216592012577 hexamer interface [polypeptide binding]; other site 216592012578 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 216592012579 NAD binding site [chemical binding]; other site 216592012580 substrate binding site [chemical binding]; other site 216592012581 active site 216592012582 HMMPfam hit to PF00551, Formyl transferase, score 2.2e-16 216592012583 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 4.8e-35 216592012584 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 216592012585 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 216592012586 putative active site [active] 216592012587 putative catalytic site [active] 216592012588 putative Zn binding site [ion binding]; other site 216592012589 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 6.7e-06 216592012590 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 216592012591 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216592012592 HMMPfam hit to PF02366, Dolichyl-phosphate-mannose-protein mannosylt, score 3.2e-70 216592012593 12 probable transmembrane helices predicted for EC042_2500 by TMHMM2.0 at aa 7-29, 82-104, 111-133, 137-154, 167-189, 204-226, 257-279, 289-308, 315-334, 344-366, 379-401 and 406-425 216592012594 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012595 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 216592012596 Signal peptide predicted for EC042_2501 by SignalP 2.0 HMM (Signal peptide probability 0.878) with cleavage site probability 0.411 between residues 20 and 21 216592012597 3 probable transmembrane helices predicted for EC042_2501 by TMHMM2.0 at aa 36-58, 63-82 and 89-108 216592012598 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 216592012599 Signal peptide predicted for EC042_2502 by SignalP 2.0 HMM (Signal peptide probability 0.862) with cleavage site probability 0.430 between residues 21 and 22 216592012600 4 probable transmembrane helices predicted for EC042_2502 by TMHMM2.0 at aa 5-27, 37-59, 72-94 and 99-121 216592012601 signal transduction protein PmrD; Provisional; Region: PRK15450 216592012602 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 216592012603 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 216592012604 acyl-activating enzyme (AAE) consensus motif; other site 216592012605 putative AMP binding site [chemical binding]; other site 216592012606 putative active site [active] 216592012607 putative CoA binding site [chemical binding]; other site 216592012608 HMMPfam hit to PF00501, AMP-binding enzyme, score 9.8e-70 216592012609 PS00455 Putative AMP-binding domain signature. 216592012611 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 0.00011 216592012612 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216592012613 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 216592012614 substrate binding site [chemical binding]; other site 216592012615 oxyanion hole (OAH) forming residues; other site 216592012616 trimer interface [polypeptide binding]; other site 216592012617 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.6e-72 216592012618 PS00166 Enoyl-CoA hydratase/isomerase signature. 216592012619 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 216592012620 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 216592012621 nucleophilic elbow; other site 216592012622 catalytic triad; other site 216592012623 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2.7e-07 216592012624 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 216592012625 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 216592012626 dimer interface [polypeptide binding]; other site 216592012627 tetramer interface [polypeptide binding]; other site 216592012628 PYR/PP interface [polypeptide binding]; other site 216592012629 TPP binding site [chemical binding]; other site 216592012630 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 216592012631 TPP-binding site; other site 216592012632 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 0.00076 216592012633 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 216592012634 isochorismate synthases; Region: isochor_syn; TIGR00543 216592012635 HMMPfam hit to PF00425, chorismate binding enzyme, score 1.9e-118 216592012636 hypothetical protein; Provisional; Region: PRK10404 216592012637 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 1.6e-50 216592012638 1 probable transmembrane helix predicted for EC042_2510 by TMHMM2.0 at aa 80-99 216592012639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592012640 Coenzyme A binding pocket [chemical binding]; other site 216592012641 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-11 216592012642 ribonuclease BN; Region: true_RNase_BN; TIGR02649 216592012643 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.5e-11 216592012644 deubiquitinase; Provisional; Region: PRK11836; cl08202 216592012645 HMMPfam hit to PF02902, Ulp1 protease family, C-terminal cataly, score 1.4e-30 216592012646 von Willebrand factor; Region: vWF_A; pfam12450 216592012647 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 216592012648 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 216592012649 metal ion-dependent adhesion site (MIDAS); other site 216592012650 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 216592012651 HMMPfam hit to PF00092, von Willebrand factor type A domain, score 3.4e-26 216592012652 Signal peptide predicted for EC042_2514 by SignalP 2.0 HMM (Signal peptide probability 0.976) with cleavage site probability 0.357 between residues 24 and 25 216592012653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592012654 M28 Zn-Peptidases; Region: M28_like_1; cd05640 216592012655 Peptidase family M28; Region: Peptidase_M28; pfam04389 216592012656 metal binding site [ion binding]; metal-binding site 216592012657 Signal peptide predicted for EC042_2515 by SignalP 2.0 HMM (Signal peptide probability 0.985) with cleavage site probability 0.826 between residues 36 and 37 216592012658 1 probable transmembrane helix predicted for EC042_2515 by TMHMM2.0 at aa 7-26 216592012659 HMMPfam hit to PF04389, Peptidase family M28, score 1.1e-20 216592012660 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 216592012661 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592012662 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 216592012663 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592012664 14 probable transmembrane helices predicted for EC042_2517 by TMHMM2.0 at aa 10-30, 35-57, 72-94, 106-120, 125-147, 159-181, 201-223, 236-258, 268-290, 297-319, 329-351, 371-393, 408-430 and 450-472 216592012665 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 9e-105 216592012666 Signal peptide predicted for EC042_2517 by SignalP 2.0 HMM (Signal peptide probability 0.780) with cleavage site probability 0.211 between residues 26 and 27 216592012667 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 216592012668 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592012669 14 probable transmembrane helices predicted for EC042_2518 by TMHMM2.0 at aa 4-18, 30-49, 81-103, 115-134, 139-161, 174-196, 222-244, 251-273, 288-307, 314-336, 341-363, 384-406, 416-438 and 459-481 216592012670 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 9.6e-80 216592012671 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 216592012672 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 216592012673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592012674 16 probable transmembrane helices predicted for EC042_2519 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 277-299, 306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612 216592012675 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex, score 6.5e-126 216592012676 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 2.7e-30 216592012677 Signal peptide predicted for EC042_2519 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.721 between residues 26 and 27 216592012678 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 216592012679 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 5.9e-32 216592012680 3 probable transmembrane helices predicted for EC042_2520 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 216592012681 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 216592012682 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreduct, score 2e-15 216592012683 5 probable transmembrane helices predicted for EC042_2521 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 216592012684 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 216592012685 4Fe-4S binding domain; Region: Fer4; pfam00037 216592012686 4Fe-4S binding domain; Region: Fer4; pfam00037 216592012687 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.6e-08 216592012688 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012689 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00011 216592012690 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592012691 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 216592012692 8 probable transmembrane helices predicted for EC042_2523 by TMHMM2.0 at aa 10-32, 81-103, 113-135, 155-174, 184-206, 235-257, 267-289 and 302-324 216592012693 HMMPfam hit to PF00146, NADH dehydrogenase, score 6e-179 216592012694 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 216592012695 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 216592012696 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 216592012697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592012698 catalytic loop [active] 216592012699 iron binding site [ion binding]; other site 216592012700 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 216592012701 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 216592012702 [4Fe-4S] binding site [ion binding]; other site 216592012703 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 216592012704 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 4e-15 216592012705 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 216592012706 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 216592012707 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding dom, score 5.3e-13 216592012708 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 216592012709 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 216592012710 SLBB domain; Region: SLBB; pfam10531 216592012711 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 216592012712 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 216592012713 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 4.8e-182 216592012714 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 216592012715 NADH dehydrogenase subunit E; Validated; Region: PRK07539 216592012716 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 216592012717 putative dimer interface [polypeptide binding]; other site 216592012718 [2Fe-2S] cluster binding site [ion binding]; other site 216592012719 HMMPfam hit to PF01257, Respiratory-chain NADH dehydrogenase, score 3.1e-109 216592012720 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 216592012721 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 216592012722 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 216592012723 NADH dehydrogenase subunit D; Validated; Region: PRK06075 216592012724 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 4.1e-188 216592012725 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 216592012726 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 3.3e-41 216592012727 PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature. 216592012728 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 216592012729 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1e-56 216592012730 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 216592012731 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 216592012732 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreduct, score 2.5e-41 216592012733 3 probable transmembrane helices predicted for EC042_2529 by TMHMM2.0 at aa 15-37, 66-88 and 98-120 216592012734 PS00012 Phosphopantetheine attachment site. 216592012735 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 216592012736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592012737 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 216592012738 putative dimerization interface [polypeptide binding]; other site 216592012739 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.2e-28 216592012740 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216592012741 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8e-16 216592012742 PS00044 Bacterial regulatory proteins, lysR family signature. 216592012743 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 26-47, sequence NTFAAAAAAVCRTQSAVSQQMQ 216592012744 aminotransferase AlaT; Validated; Region: PRK09265 216592012745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592012746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592012747 homodimer interface [polypeptide binding]; other site 216592012748 catalytic residue [active] 216592012749 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.9e-37 216592012750 5'-nucleotidase; Provisional; Region: PRK03826 216592012751 HMMPfam hit to PF01966, HD domain, score 7.3e-17 216592012752 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 216592012753 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216592012754 TrkA-C domain; Region: TrkA_C; pfam02080 216592012755 TrkA-C domain; Region: TrkA_C; pfam02080 216592012756 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 216592012757 10 probable transmembrane helices predicted for EC042_2533 by TMHMM2.0 at aa 5-24, 28-50, 57-79, 94-125, 138-160, 173-195, 470-492, 502-524, 544-566 and 586-608 216592012758 PS01271 Sodium:sulfate symporter family signature. 216592012759 HMMPfam hit to PF02080, TrkA-C domain, score 1.1e-11 216592012760 HMMPfam hit to PF02080, TrkA-C domain, score 5.6e-12 216592012761 Signal peptide predicted for EC042_2533 by SignalP 2.0 HMM (Signal peptide probability 0.806) with cleavage site probability 0.214 between residues 25 and 26 216592012762 putative phosphatase; Provisional; Region: PRK11587 216592012763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592012764 motif II; other site 216592012765 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2e-42 216592012766 hypothetical protein; Validated; Region: PRK05445 216592012767 HMMPfam hit to PF03887, YfbU domain, score 3.6e-117 216592012768 hypothetical protein; Provisional; Region: PRK01816 216592012769 HMMPfam hit to PF04217, Protein of unknown function, DUF412, score 6.1e-112 216592012770 2 probable transmembrane helices predicted for EC042_2536 by TMHMM2.0 at aa 46-65 and 69-91 216592012771 propionate/acetate kinase; Provisional; Region: PRK12379 216592012772 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 216592012773 HMMPfam hit to PF00871, Acetokinase family, score 7.2e-256 216592012774 PS01075 Acetate and butyrate kinases family signature 1. 216592012775 PS01076 Acetate and butyrate kinases family signature 2. 216592012776 phosphate acetyltransferase; Reviewed; Region: PRK05632 216592012777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216592012778 DRTGG domain; Region: DRTGG; pfam07085 216592012779 phosphate acetyltransferase; Region: pta; TIGR00651 216592012780 HMMPfam hit to PF07085, DRTGG domain, score 3.2e-58 216592012781 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 6.8e-194 216592012782 hypothetical protein; Provisional; Region: PRK11588 216592012783 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 216592012784 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 8e-248 216592012785 11 probable transmembrane helices predicted for EC042_2539 by TMHMM2.0 at aa 26-48, 113-134, 155-172, 182-204, 211-233, 237-259, 294-316, 321-343, 356-378, 405-422 and 488-510 216592012786 PS00012 Phosphopantetheine attachment site. 216592012787 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 216592012788 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 216592012789 nudix motif; other site 216592012790 HMMPfam hit to PF00293, NUDIX domain, score 1.7e-25 216592012791 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 216592012792 active site 216592012793 metal binding site [ion binding]; metal-binding site 216592012794 homotetramer interface [polypeptide binding]; other site 216592012795 PS01269 Uncharacterized protein family UPF0025 signature. 216592012796 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.7e-19 216592012797 glutathione S-transferase; Provisional; Region: PRK15113 216592012798 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216592012799 C-terminal domain interface [polypeptide binding]; other site 216592012800 GSH binding site (G-site) [chemical binding]; other site 216592012801 dimer interface [polypeptide binding]; other site 216592012802 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 216592012803 N-terminal domain interface [polypeptide binding]; other site 216592012804 putative dimer interface [polypeptide binding]; other site 216592012805 putative substrate binding pocket (H-site) [chemical binding]; other site 216592012806 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 3.1e-14 216592012807 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 216592012808 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 216592012809 C-terminal domain interface [polypeptide binding]; other site 216592012810 GSH binding site (G-site) [chemical binding]; other site 216592012811 dimer interface [polypeptide binding]; other site 216592012812 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 216592012813 N-terminal domain interface [polypeptide binding]; other site 216592012814 putative dimer interface [polypeptide binding]; other site 216592012815 active site 216592012816 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.3e-10 216592012817 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 2.2e-06 216592012818 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 216592012819 homooctamer interface [polypeptide binding]; other site 216592012820 active site 216592012821 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 7.2e-46 216592012822 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 216592012823 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 216592012824 putative NAD(P) binding site [chemical binding]; other site 216592012825 putative active site [active] 216592012826 putative transposase; Provisional; Region: PRK09857 216592012827 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 216592012828 HMMPfam hit to PF04754, Putative transposase, YhgA-like, score 2.1e-219 216592012829 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 216592012830 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216592012831 Walker A/P-loop; other site 216592012832 ATP binding site [chemical binding]; other site 216592012833 Q-loop/lid; other site 216592012834 ABC transporter signature motif; other site 216592012835 Walker B; other site 216592012836 D-loop; other site 216592012837 H-loop/switch region; other site 216592012838 HMMPfam hit to PF00005, ABC transporter, score 1.1e-63 216592012839 PS00211 ABC transporters family signature. 216592012840 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592012842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592012843 dimer interface [polypeptide binding]; other site 216592012844 conserved gate region; other site 216592012845 putative PBP binding loops; other site 216592012846 ABC-ATPase subunit interface; other site 216592012847 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.2e-19 216592012848 4 probable transmembrane helices predicted for EC042_2548 by TMHMM2.0 at aa 25-47, 57-79, 167-189 and 199-221 216592012849 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592012850 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592012851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592012852 dimer interface [polypeptide binding]; other site 216592012853 conserved gate region; other site 216592012854 putative PBP binding loops; other site 216592012855 ABC-ATPase subunit interface; other site 216592012856 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.7e-35 216592012857 5 probable transmembrane helices predicted for EC042_2549 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213 216592012858 PS00017 ATP/GTP-binding site motif A (P-loop). 216592012859 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592012860 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 216592012861 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592012862 substrate binding pocket [chemical binding]; other site 216592012863 membrane-bound complex binding site; other site 216592012864 hinge residues; other site 216592012865 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.6e-98 216592012866 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592012867 1 probable transmembrane helix predicted for EC042_2550 by TMHMM2.0 at aa 5-24 216592012868 Signal peptide predicted for EC042_2550 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 22 and 23 216592012869 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 216592012870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592012871 substrate binding pocket [chemical binding]; other site 216592012872 membrane-bound complex binding site; other site 216592012873 hinge residues; other site 216592012874 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 3.9e-88 216592012875 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592012876 Signal peptide predicted for EC042_2551 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.925 between residues 22 and 23 216592012877 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 216592012878 Flavoprotein; Region: Flavoprotein; pfam02441 216592012879 HMMPfam hit to PF02441, Flavoprotein, score 2.3e-52 216592012880 amidophosphoribosyltransferase; Provisional; Region: PRK09246 216592012881 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 216592012882 active site 216592012883 tetramer interface [polypeptide binding]; other site 216592012884 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592012885 active site 216592012886 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 5.8e-13 216592012887 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592012888 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 5.3e-73 216592012889 PS00443 Glutamine amidotransferases class-II active site. 216592012890 colicin V production protein; Provisional; Region: PRK10845 216592012891 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 216592012892 HMMPfam hit to PF02674, Colicin V production protein, score 2.3e-62 216592012893 4 probable transmembrane helices predicted for EC042_2554 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 216592012894 cell division protein DedD; Provisional; Region: PRK11633 216592012895 Sporulation related domain; Region: SPOR; pfam05036 216592012896 HMMPfam hit to PF05036, Sporulation related repeat, score 0.13 216592012897 HMMPfam hit to PF05036, Sporulation related repeat, score 6.9e-07 216592012898 1 probable transmembrane helix predicted for EC042_2555 by TMHMM2.0 at aa 13-35 216592012899 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 216592012900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592012901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592012902 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 0.0019 216592012903 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.6e-08 216592012904 PS01012 Folylpolyglutamate synthase signature 2. 216592012905 PS01011 Folylpolyglutamate synthase signature 1. 216592012906 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 216592012907 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216592012908 hypothetical protein; Provisional; Region: PRK10847 216592012909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216592012910 4 probable transmembrane helices predicted for EC042_2558 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208 216592012911 HMMPfam hit to PF00597, DedA family, score 9e-68 216592012912 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216592012913 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 216592012914 dimerization interface 3.5A [polypeptide binding]; other site 216592012915 active site 216592012916 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 8.1e-30 216592012917 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 6.2e-39 216592012918 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 216592012919 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216592012920 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 2e-62 216592012921 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 3.3e-51 216592012922 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 216592012923 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 216592012924 ligand binding site [chemical binding]; other site 216592012925 NAD binding site [chemical binding]; other site 216592012926 catalytic site [active] 216592012927 homodimer interface [polypeptide binding]; other site 216592012928 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 4.3e-66 216592012929 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216592012930 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216592012931 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 5.8e-21 216592012932 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 216592012933 1 probable transmembrane helix predicted for EC042_2562 by TMHMM2.0 at aa 313-330 216592012934 putative transporter; Provisional; Region: PRK12382 216592012935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592012936 putative substrate translocation pore; other site 216592012937 12 probable transmembrane helices predicted for EC042_2563 by TMHMM2.0 at aa 20-42, 52-71, 83-105, 120-142, 149-171, 176-198, 210-232, 247-269, 276-298, 303-325, 338-360 and 370-389 216592012938 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.3e-36 216592012939 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 216592012940 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216592012941 dimer interface [polypeptide binding]; other site 216592012942 active site 216592012943 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 4.3e-58 216592012944 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 5e-58 216592012945 PS00606 Beta-ketoacyl synthases active site. 216592012946 Uncharacterized conserved protein [Function unknown]; Region: COG4121 216592012947 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 216592012948 HMMPfam hit to PF05430, Protein of unknown function (DUF752), score 2.2e-153 216592012949 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1e-58 216592012950 YfcL protein; Region: YfcL; pfam08891 216592012951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 216592012952 HMMPfam hit to PF04315, Protein of unknown function, DUF462, score 9e-154 216592012953 hypothetical protein; Provisional; Region: PRK10621 216592012954 Predicted permeases [General function prediction only]; Region: COG0730 216592012955 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 1.3e-64 216592012956 7 probable transmembrane helices predicted for EC042_2568 by TMHMM2.0 at aa 7-28, 32-54, 85-104, 108-127, 140-159, 163-182 and 195-217 216592012957 Signal peptide predicted for EC042_2568 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.469 between residues 53 and 54 216592012958 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 216592012959 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 216592012960 HMMPfam hit to PF03411, Penicillin-insensitive murein endopeptid, score 8.4e-204 216592012961 Signal peptide predicted for EC042_2569 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 19 and 20 216592012962 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 216592012963 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 216592012964 Tetramer interface [polypeptide binding]; other site 216592012965 active site 216592012966 FMN-binding site [chemical binding]; other site 216592012967 HMMPfam hit to PF01264, Chorismate synthase, score 3.4e-242 216592012968 PS00789 Chorismate synthase signature 3. 216592012969 PS00788 Chorismate synthase signature 2. 216592012970 PS00787 Chorismate synthase signature 1. 216592012971 HemK family putative methylases; Region: hemK_fam; TIGR00536 216592012972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592012973 S-adenosylmethionine binding site [chemical binding]; other site 216592012974 PS00092 N-6 Adenine-specific DNA methylases signature. 216592012975 hypothetical protein; Provisional; Region: PRK04946 216592012976 Smr domain; Region: Smr; pfam01713 216592012977 HMMPfam hit to PF01713, Smr domain, score 1.1e-32 216592012978 Fimbrial operon 8. Sequence divergence between 0157 and Uropathogenic strains 216592012979 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 216592012980 1 probable transmembrane helix predicted for EC042_2573 by TMHMM2.0 at aa 5-27 216592012981 Signal peptide predicted for EC042_2573 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.982 between residues 19 and 20 216592012982 Fimbrial protein; Region: Fimbrial; cl01416 216592012983 HMMPfam hit to PF00419, Fimbrial protein, score 4.6e-11 216592012984 1 probable transmembrane helix predicted for EC042_2574 by TMHMM2.0 at aa 12-31 216592012985 Signal peptide predicted for EC042_2574 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 30 and 31 216592012986 Fimbrial protein; Region: Fimbrial; cl01416 216592012987 HMMPfam hit to PF00419, Fimbrial protein, score 0.0016 216592012988 Signal peptide predicted for EC042_2575 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 18 and 19 216592012989 Fimbrial protein; Region: Fimbrial; cl01416 216592012990 Signal peptide predicted for EC042_2576 by SignalP 2.0 HMM (Signal peptide probability 0.870) with cleavage site probability 0.864 between residues 15 and 16 216592012991 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 216592012992 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592012993 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592012994 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 8.9e-06 216592012995 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.3e-42 216592012996 PS00635 Gram-negative pili assembly chaperone signature. 216592012997 Signal peptide predicted for EC042_2577 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 27 and 28 216592012998 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 216592012999 PapC N-terminal domain; Region: PapC_N; pfam13954 216592013000 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592013001 PapC C-terminal domain; Region: PapC_C; pfam13953 216592013002 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592013003 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592013004 Signal peptide predicted for EC042_2578 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.994 between residues 29 and 30 216592013005 Fimbrial protein; Region: Fimbrial; cl01416 216592013006 HMMPfam hit to PF00419, Fimbrial protein, score 8.3e-26 216592013007 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013008 Signal peptide predicted for EC042_2579 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.981 between residues 25 and 26 216592013009 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216592013010 catalytic core [active] 216592013011 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 216592013012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216592013013 substrate binding site [chemical binding]; other site 216592013014 oxyanion hole (OAH) forming residues; other site 216592013015 trimer interface [polypeptide binding]; other site 216592013016 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216592013017 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216592013018 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.00046 216592013019 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1e-41 216592013020 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 216592013021 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 8.2e-83 216592013022 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.3e-69 216592013023 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 216592013024 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216592013025 dimer interface [polypeptide binding]; other site 216592013026 active site 216592013027 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 2e-50 216592013028 PS00099 Thiolases active site. 216592013029 PS00737 Thiolases signature 2. 216592013030 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 2.8e-65 216592013031 PS00098 Thiolases acyl-enzyme intermediate signature. 216592013032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 216592013033 HMMPfam hit to PF04175, Protein of unknown function (DUF406), score 3.6e-64 216592013034 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 216592013035 Signal peptide predicted for EC042_2584 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 27 and 28 216592013036 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 1.1e-195 216592013037 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 216592013038 HMMPfam hit to PF04333, VacJ like lipoprotein, score 1.7e-126 216592013039 Signal peptide predicted for EC042_2587 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.361 between residues 23 and 24 216592013040 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013041 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 216592013042 6 probable transmembrane helices predicted for EC042_2588 by TMHMM2.0 at aa 59-81, 91-113, 134-156, 187-206, 213-232 and 252-274 216592013043 Present in Uropathogenic, divergent in 0157, putative autotransporter protein-pseudogene (lacking N-terminal region) and transposases, probable deletion in 042 216592013044 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 216592013045 1 probable transmembrane helix predicted for EC042_2589 by TMHMM2.0 at aa 7-26 216592013047 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3.3e-39 216592013048 HMMPfam hit to PF03212, Pertactin, score 3.4e-05 216592013049 HMMPfam hit to PF05594, no description, score 5.1 216592013050 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013051 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 216592013052 HMMPfam hit to PF03400, IS1 transposase, score 1e-103 216592013053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592013054 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592013055 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592013056 HMMPfam hit to PF03811, Insertion element protein, score 9.5e-70 216592013057 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592013058 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013060 PS00177 DNA topoisomerase II signature. 216592013061 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 3.2e-37 216592013062 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.9e-58 216592013063 formyl-coenzyme A transferase; Provisional; Region: PRK05398 216592013064 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216592013065 HMMPfam hit to PF02515, CoA-transferase family III, score 1.3e-117 216592013066 hypothetical protein; Provisional; Region: PRK10316 216592013067 YfdX protein; Region: YfdX; pfam10938 216592013068 Signal peptide predicted for EC042_2595 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 21 and 22 216592013069 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 216592013070 3 probable transmembrane helices predicted for EC042_2596 by TMHMM2.0 at aa 4-26, 28-50 and 55-77 216592013071 Signal peptide predicted for EC042_2596 by SignalP 2.0 HMM (Signal peptide probability 0.919) with cleavage site probability 0.350 between residues 24 and 25 216592013072 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216592013073 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216592013074 putative acyl-acceptor binding pocket; other site 216592013075 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 4.9e-159 216592013076 1 probable transmembrane helix predicted for EC042_2597 by TMHMM2.0 at aa 39-61 216592013077 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592013078 aminotransferase; Validated; Region: PRK08175 216592013079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592013080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592013081 homodimer interface [polypeptide binding]; other site 216592013082 catalytic residue [active] 216592013083 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.5e-45 216592013084 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 216592013085 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 216592013086 GAF domain; Region: GAF; pfam01590 216592013087 Histidine kinase; Region: His_kinase; pfam06580 216592013088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592013089 ATP binding site [chemical binding]; other site 216592013090 Mg2+ binding site [ion binding]; other site 216592013091 G-X-G motif; other site 216592013092 6 probable transmembrane helices predicted for EC042_2599 by TMHMM2.0 at aa 4-26, 45-62, 77-99, 106-128, 138-160 and 169-191 216592013093 HMMPfam hit to PF07694, 5TMR of 5TMR-LYT, score 2.2e-39 216592013094 HMMPfam hit to PF01590, GAF domain, score 4.6e-05 216592013095 HMMPfam hit to PF06580, Histidine kinase, score 2.2e-41 216592013096 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 9.6e-16 216592013097 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216592013098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592013099 active site 216592013100 phosphorylation site [posttranslational modification] 216592013101 intermolecular recognition site; other site 216592013102 dimerization interface [polypeptide binding]; other site 216592013103 LytTr DNA-binding domain; Region: LytTR; pfam04397 216592013104 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.1e-33 216592013105 HMMPfam hit to PF04397, LytTr DNA-binding domain, score 1.3e-29 216592013106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592013107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592013108 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00024 216592013109 Predicted helix-turn-helix motif with score 1814.000, SD 5.37 at aa 198-219, sequence LTRESVAQFFNITPNHLSKLFA 216592013110 PS00041 Bacterial regulatory proteins, araC family signature. 216592013111 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.1e-11 216592013112 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592013113 dimerization domain swap beta strand [polypeptide binding]; other site 216592013114 regulatory protein interface [polypeptide binding]; other site 216592013115 active site 216592013116 regulatory phosphorylation site [posttranslational modification]; other site 216592013117 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216592013118 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216592013119 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592013120 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216592013121 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592013122 active site 216592013123 phosphorylation site [posttranslational modification] 216592013124 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar p, score 3.9e-06 216592013125 PS00215 Mitochondrial energy transfer proteins signature. 216592013126 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2e-144 216592013127 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 2.1e-20 216592013128 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 4.1e-05 216592013129 HMMPfam hit to PF00381, PTS HPr component phosphorylation sit, score 4.7e-05 216592013130 exoaminopeptidase; Provisional; Region: PRK09961 216592013131 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 216592013132 oligomer interface [polypeptide binding]; other site 216592013133 active site 216592013134 metal binding site [ion binding]; metal-binding site 216592013135 HMMPfam hit to PF05343, M42 glutamyl aminopeptidase, score 2.3e-118 216592013136 aminopeptidase; Provisional; Region: PRK09795 216592013137 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216592013138 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 216592013139 active site 216592013140 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.1e-74 216592013141 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 216592013142 10 probable transmembrane helices predicted for EC042_2605 by TMHMM2.0 at aa 46-68, 97-119, 126-145, 160-178, 198-220, 240-262, 275-297, 317-335, 342-364 and 379-401 216592013143 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.6e-06 216592013144 Signal peptide predicted for EC042_2605 by SignalP 2.0 HMM (Signal peptide probability 0.996) with cleavage site probability 0.536 between residues 20 and 21 216592013145 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 216592013146 active site 216592013147 P-loop; other site 216592013148 phosphorylation site [posttranslational modification] 216592013149 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 2e-59 216592013150 Signal peptide predicted for EC042_2606 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.786 between residues 21 and 22 216592013151 glucokinase, proteobacterial type; Region: glk; TIGR00749 216592013152 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592013153 nucleotide binding site [chemical binding]; other site 216592013154 HMMPfam hit to PF02685, Glucokinase, score 9.5e-241 216592013155 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216592013156 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 216592013157 Cl- selectivity filter; other site 216592013158 Cl- binding residues [ion binding]; other site 216592013159 pore gating glutamate residue; other site 216592013160 dimer interface [polypeptide binding]; other site 216592013161 Signal peptide predicted for EC042_2608 by SignalP 2.0 HMM (Signal peptide probability 0.958) with cleavage site probability 0.472 between residues 24 and 25 216592013162 11 probable transmembrane helices predicted for EC042_2608 by TMHMM2.0 at aa 9-31, 55-77, 90-112, 122-140, 147-169, 189-211, 223-244, 259-281, 301-323, 343-363 and 376-398 216592013163 HMMPfam hit to PF00654, Voltage gated chloride channel, score 2.2e-05 216592013164 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 216592013165 Signal peptide predicted for EC042_2609 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.984 between residues 21 and 22 216592013166 manganese transport protein MntH; Reviewed; Region: PRK00701 216592013167 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216592013168 11 probable transmembrane helices predicted for EC042_2610 by TMHMM2.0 at aa 20-39, 54-76, 96-118, 123-145, 157-176, 196-218, 239-261, 290-312, 324-343, 348-370 and 391-410 216592013169 HMMPfam hit to PF01566, Natural resistance-associated macrophage pro, score 4.2e-204 216592013170 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 216592013171 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 216592013172 Nucleoside recognition; Region: Gate; pfam07670 216592013173 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 216592013174 8 probable transmembrane helices predicted for EC042_2611 by TMHMM2.0 at aa 15-34, 46-68, 99-121, 206-225, 262-284, 291-313, 355-377 and 390-412 216592013175 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 1.2e-33 216592013176 HMMPfam hit to PF07670, Nucleoside recognition, score 1.8e-14 216592013177 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 3.5e-101 216592013178 MASE1; Region: MASE1; pfam05231 216592013179 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592013180 diguanylate cyclase; Region: GGDEF; smart00267 216592013181 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592013182 HMMPfam hit to PF00563, EAL domain, score 1.5e-93 216592013183 HMMPfam hit to PF00990, GGDEF domain, score 0.0011 216592013184 HMMPfam hit to PF05231, MASE1, score 1.2e-66 216592013185 8 probable transmembrane helices predicted for EC042_2612 by TMHMM2.0 at aa 31-53, 60-82, 102-124, 145-167, 182-204, 235-254, 258-275 and 309-331 216592013186 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 216592013187 HMMPfam hit to PF07037, Protein of unknown function (DUF1323), score 1.9e-79 216592013188 Predicted helix-turn-helix motif with score 1941.000, SD 5.80 at aa 1-22, sequence MTPDELARLTGYSRQTINKWVR 216592013189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592013190 salt bridge; other site 216592013191 non-specific DNA binding site [nucleotide binding]; other site 216592013192 sequence-specific DNA binding site [nucleotide binding]; other site 216592013193 HMMPfam hit to PF07037, Protein of unknown function (DUF1323), score 2.4e-86 216592013194 Predicted helix-turn-helix motif with score 2426.000, SD 7.45 at aa 1-22, sequence MTTEELAECLGVAKQTVNRWIR 216592013195 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 216592013196 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216592013197 active site 216592013198 HIGH motif; other site 216592013199 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216592013200 active site 216592013201 KMSKS motif; other site 216592013202 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 4.2e-191 216592013203 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592013204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592013205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592013206 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216592013207 putative dimerization interface [polypeptide binding]; other site 216592013208 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.4e-51 216592013209 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.6e-23 216592013210 PS00044 Bacterial regulatory proteins, lysR family signature. 216592013211 Predicted helix-turn-helix motif with score 1532.000, SD 4.40 at aa 18-39, sequence KSFSRAGERIGLSQSAVSHSVK 216592013212 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 216592013213 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 216592013214 Signal peptide predicted for EC042_2619 by SignalP 2.0 HMM (Signal peptide probability 0.934) with cleavage site probability 0.805 between residues 28 and 29 216592013215 9 probable transmembrane helices predicted for EC042_2619 by TMHMM2.0 at aa 7-26, 30-47, 67-89, 99-118, 130-152, 167-186, 203-225, 229-251 and 272-294 216592013216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 216592013217 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 216592013218 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 216592013219 nucleotide binding pocket [chemical binding]; other site 216592013220 K-X-D-G motif; other site 216592013221 catalytic site [active] 216592013222 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216592013223 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 216592013224 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 216592013225 Dimer interface [polypeptide binding]; other site 216592013226 BRCT sequence motif; other site 216592013227 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1.2e-20 216592013228 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.4e-05 216592013229 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 9.1e-13 216592013230 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 3.7e-53 216592013231 PS01056 NAD-dependent DNA ligase signature 2. 216592013232 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 4.4e-218 216592013233 PS01055 NAD-dependent DNA ligase signature 1. 216592013234 cell division protein ZipA; Provisional; Region: PRK03427 216592013235 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 216592013236 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 216592013237 FtsZ protein binding site [polypeptide binding]; other site 216592013238 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding domain, score 3.4e-94 216592013239 1 probable transmembrane helix predicted for EC042_2621 by TMHMM2.0 at aa 22-44 216592013240 putative sulfate transport protein CysZ; Validated; Region: PRK04949 216592013241 4 probable transmembrane helices predicted for EC042_2622 by TMHMM2.0 at aa 31-53, 68-90, 151-173 and 220-242 216592013242 HMMPfam hit to PF04401, Protein of unknown function (DUF540), score 3.6e-115 216592013243 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216592013244 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216592013245 dimer interface [polypeptide binding]; other site 216592013246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592013247 catalytic residue [active] 216592013248 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1e-128 216592013249 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 216592013250 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592013251 dimerization domain swap beta strand [polypeptide binding]; other site 216592013252 regulatory protein interface [polypeptide binding]; other site 216592013253 active site 216592013254 regulatory phosphorylation site [posttranslational modification]; other site 216592013255 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 6.3e-48 216592013256 PS00369 PTS HPR component histidine phosphorylation site signature. 216592013257 PS00589 PTS HPR component serine phosphorylation site signature. 216592013258 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 216592013259 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216592013260 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592013261 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216592013262 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 3.9e-60 216592013263 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 1.8e-34 216592013264 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216592013265 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.6e-194 216592013266 PS00742 PEP-utilizing enzymes signature 2. 216592013267 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 216592013268 HPr interaction site; other site 216592013269 glycerol kinase (GK) interaction site [polypeptide binding]; other site 216592013270 active site 216592013271 phosphorylation site [posttranslational modification] 216592013272 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 1.2e-67 216592013273 PS00371 PTS EIIA domains phosphorylation site signature 1. 216592013274 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 216592013275 dimer interface [polypeptide binding]; other site 216592013276 pyridoxamine kinase; Validated; Region: PRK05756 216592013277 pyridoxal binding site [chemical binding]; other site 216592013278 ATP binding site [chemical binding]; other site 216592013279 hypothetical protein; Provisional; Region: PRK10318 216592013280 Signal peptide predicted for EC042_2628 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 19 and 20 216592013281 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216592013282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 216592013283 HMMPfam hit to PF05406, WGR domain, score 5.7e-22 216592013284 cysteine synthase B; Region: cysM; TIGR01138 216592013285 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216592013286 dimer interface [polypeptide binding]; other site 216592013287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592013288 catalytic residue [active] 216592013289 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 4.7e-114 216592013290 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 216592013291 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 216592013292 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 216592013293 Walker A/P-loop; other site 216592013294 ATP binding site [chemical binding]; other site 216592013295 Q-loop/lid; other site 216592013296 ABC transporter signature motif; other site 216592013297 Walker B; other site 216592013298 D-loop; other site 216592013299 H-loop/switch region; other site 216592013300 TOBE-like domain; Region: TOBE_3; pfam12857 216592013301 HMMPfam hit to PF00005, ABC transporter, score 8.5e-74 216592013302 PS00211 ABC transporters family signature. 216592013303 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013304 sulfate transport protein; Provisional; Region: cysT; CHL00187 216592013305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592013306 dimer interface [polypeptide binding]; other site 216592013307 conserved gate region; other site 216592013308 putative PBP binding loops; other site 216592013309 ABC-ATPase subunit interface; other site 216592013310 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.4e-16 216592013311 5 probable transmembrane helices predicted for EC042_2632 by TMHMM2.0 at aa 15-40, 53-75, 90-112, 151-173 and 196-218 216592013312 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592013313 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216592013314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592013315 dimer interface [polypeptide binding]; other site 216592013316 conserved gate region; other site 216592013317 putative PBP binding loops; other site 216592013318 ABC-ATPase subunit interface; other site 216592013319 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.3e-39 216592013320 7 probable transmembrane helices predicted for EC042_2633 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266 216592013321 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592013322 Signal peptide predicted for EC042_2633 by SignalP 2.0 HMM (Signal peptide probability 0.993) with cleavage site probability 0.816 between residues 36 and 37 216592013323 thiosulfate transporter subunit; Provisional; Region: PRK10852 216592013324 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216592013325 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2.1e-11 216592013326 PS00757 Prokaryotic sulfate-binding proteins signature 2. 216592013327 PS00401 Prokaryotic sulfate-binding proteins signature 1. 216592013328 PS00092 N-6 Adenine-specific DNA methylases signature. 216592013329 Signal peptide predicted for EC042_2634 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 25 and 26 216592013330 short chain dehydrogenase; Provisional; Region: PRK08226 216592013331 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 216592013332 NAD binding site [chemical binding]; other site 216592013333 homotetramer interface [polypeptide binding]; other site 216592013334 homodimer interface [polypeptide binding]; other site 216592013335 active site 216592013336 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.1e-79 216592013337 transcriptional regulator MurR; Provisional; Region: PRK15482 216592013338 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216592013339 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216592013340 putative active site [active] 216592013341 HMMPfam hit to PF01380, SIS domain, score 5.6e-24 216592013342 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 8.7e-52 216592013343 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 35-56, sequence VSSRKMAKQLGISQSSIVKFAQ 216592013344 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 216592013345 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 216592013346 putative active site [active] 216592013347 PS01272 Glucokinase regulatory protein family signature. 216592013348 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 216592013349 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592013350 active site turn [active] 216592013351 phosphorylation site [posttranslational modification] 216592013352 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 216592013353 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 2e-09 216592013354 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592013355 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.8e-54 216592013356 10 probable transmembrane helices predicted for EC042_2638 by TMHMM2.0 at aa 121-143, 158-177, 184-203, 218-240, 261-283, 298-320, 332-354, 369-388, 395-417 and 444-466 216592013357 PS00024 Hemopexin domain signature. 216592013358 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 216592013359 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 7.8e-164 216592013360 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 216592013361 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 216592013362 HMMPfam hit to PF06572, Protein of unknown function (DUF1131), score 1.4e-169 216592013363 Signal peptide predicted for EC042_2640 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.583 between residues 27 and 28 216592013364 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013365 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 216592013366 4 probable transmembrane helices predicted for EC042_2641 by TMHMM2.0 at aa 21-43, 63-82, 89-111 and 115-137 216592013367 putative acetyltransferase; Provisional; Region: PRK03624 216592013368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592013369 Coenzyme A binding pocket [chemical binding]; other site 216592013370 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5e-22 216592013371 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 216592013372 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216592013373 active site 216592013374 metal binding site [ion binding]; metal-binding site 216592013375 Signal peptide predicted for EC042_2643 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.977 between residues 34 and 35 216592013376 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 7.2e-71 216592013377 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 216592013378 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 216592013379 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 1.3e-246 216592013380 PS01021 Coproporphyrinogen III oxidase signature. 216592013381 transcriptional regulator EutR; Provisional; Region: PRK10130 216592013382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592013383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592013384 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.00027 216592013385 PS00041 Bacterial regulatory proteins, araC family signature. 216592013386 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.6e-10 216592013387 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 257-278, sequence VTVLDLCNQLHVSRRTLQNAFH 216592013388 carboxysome structural protein EutK; Provisional; Region: PRK15466 216592013389 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 216592013390 Hexamer interface [polypeptide binding]; other site 216592013391 Hexagonal pore residue; other site 216592013392 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 1.1e-47 216592013393 PS01139 Bacterial microcompartiments proteins signature. 216592013394 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 216592013395 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 216592013396 putative hexamer interface [polypeptide binding]; other site 216592013397 putative hexagonal pore; other site 216592013398 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 216592013399 putative hexamer interface [polypeptide binding]; other site 216592013400 putative hexagonal pore; other site 216592013401 HMMPfam hit to PF06000, Ethanolamine utilisation protein EutL, score 2.5e-157 216592013402 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 216592013403 HMMPfam hit to PF05985, Ethanolamine ammonia-lyase light chain (EutC, score 7.5e-146 216592013404 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 216592013405 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 216592013406 HMMPfam hit to PF06751, Ethanolamine ammonia lyase large subunit (Eu, score 0 216592013407 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 216592013408 HMMPfam hit to PF06277, Ethanolamine utilisation protein EutA, score 0 216592013409 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 216592013410 HMMPfam hit to PF04346, Ethanolamine utilisation protein, EutH, score 3.9e-287 216592013411 10 probable transmembrane helices predicted for EC042_2651 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175, 190-212, 231-253, 273-295, 342-364 and 369-391 216592013412 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 216592013413 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 216592013414 active site 216592013415 metal binding site [ion binding]; metal-binding site 216592013416 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 9.8e-187 216592013417 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592013418 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013419 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592013420 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 216592013421 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592013422 nucleotide binding site [chemical binding]; other site 216592013423 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 216592013424 putative catalytic cysteine [active] 216592013425 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.2e-07 216592013426 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 216592013427 Hexamer/Pentamer interface [polypeptide binding]; other site 216592013428 central pore; other site 216592013429 HMMPfam hit to PF03319, Ethanolamine utilisation protein EutN/carbo, score 2.3e-53 216592013430 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 216592013431 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 216592013432 Hexamer interface [polypeptide binding]; other site 216592013433 Putative hexagonal pore residue; other site 216592013434 HMMPfam hit to PF00936, Bacterial microcompartments protein fam, score 4.3e-59 216592013435 PS01139 Bacterial microcompartiments proteins signature. 216592013436 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 216592013437 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 4.2e-186 216592013438 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 216592013439 HMMPfam hit to PF01923, Cobalamin adenosyltransferase, score 9.8e-33 216592013440 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 216592013441 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 216592013442 HMMPfam hit to PF06249, Ethanolamine utilisation protein EutQ, score 2.1e-110 216592013443 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 216592013444 G1 box; other site 216592013445 GTP/Mg2+ binding site [chemical binding]; other site 216592013446 G2 box; other site 216592013447 Switch I region; other site 216592013448 G3 box; other site 216592013449 Switch II region; other site 216592013450 G4 box; other site 216592013451 G5 box; other site 216592013452 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013453 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 216592013454 putative hexamer interface [polypeptide binding]; other site 216592013455 putative hexagonal pore; other site 216592013456 HMMPfam hit to PF06132, Ethanolamine utilisation protein EutS, score 3.2e-65 216592013457 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 216592013458 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216592013459 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216592013460 putative NAD(P) binding site [chemical binding]; other site 216592013461 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 216592013462 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.8e-124 216592013463 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 5.4e-133 216592013464 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 9.2e-84 216592013465 transaldolase-like protein; Provisional; Region: PTZ00411 216592013466 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 216592013467 active site 216592013468 dimer interface [polypeptide binding]; other site 216592013469 catalytic residue [active] 216592013470 HMMPfam hit to PF00923, Transaldolase, score 5.3e-185 216592013471 PS01054 Transaldolase signature 1. 216592013472 PS00958 Transaldolase active site. 216592013473 transketolase; Reviewed; Region: PRK12753 216592013474 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216592013475 TPP-binding site [chemical binding]; other site 216592013476 dimer interface [polypeptide binding]; other site 216592013477 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216592013478 PYR/PP interface [polypeptide binding]; other site 216592013479 dimer interface [polypeptide binding]; other site 216592013480 TPP binding site [chemical binding]; other site 216592013481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216592013482 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.4e-257 216592013483 PS00801 Transketolase signature 1. 216592013484 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 1.6e-65 216592013485 PS00802 Transketolase signature 2. 216592013486 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 3.9e-20 216592013487 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 216592013488 HMMPfam hit to PF06674, Protein of unknown function (DUF1176), score 3.3e-215 216592013489 1 probable transmembrane helix predicted for EC042_2665 by TMHMM2.0 at aa 5-24 216592013490 Signal peptide predicted for EC042_2665 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 21 and 22 216592013491 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 216592013492 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216592013493 dimer interface [polypeptide binding]; other site 216592013494 ADP-ribose binding site [chemical binding]; other site 216592013495 active site 216592013496 nudix motif; other site 216592013497 metal binding site [ion binding]; metal-binding site 216592013498 HMMPfam hit to PF00293, NUDIX domain, score 6.9e-18 216592013499 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013500 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 216592013501 4Fe-4S binding domain; Region: Fer4; pfam00037 216592013502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592013503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592013504 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 1.5e-26 216592013505 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.1e-07 216592013506 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592013507 PS00028 Zinc finger, C2H2 type, domain. 216592013508 PS00190 Cytochrome c family heme-binding site signature. 216592013509 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 216592013510 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 216592013511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592013512 dimerization interface [polypeptide binding]; other site 216592013513 Histidine kinase; Region: HisKA_3; pfam07730 216592013514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592013515 ATP binding site [chemical binding]; other site 216592013516 Mg2+ binding site [ion binding]; other site 216592013517 G-X-G motif; other site 216592013518 Signal peptide predicted for EC042_2668 by SignalP 2.0 HMM (Signal peptide probability 0.908) with cleavage site probability 0.599 between residues 39 and 40 216592013519 2 probable transmembrane helices predicted for EC042_2668 by TMHMM2.0 at aa 20-42 and 152-174 216592013520 HMMPfam hit to PF00672, HAMP domain, score 2.2e-15 216592013521 HMMPfam hit to PF07730, Histidine kinase, score 2.2e-20 216592013522 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.2e-20 216592013523 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 216592013524 Protein export membrane protein; Region: SecD_SecF; cl14618 216592013525 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592013526 Signal peptide predicted for EC042_2669 by SignalP 2.0 HMM (Signal peptide probability 0.927) with cleavage site probability 0.700 between residues 34 and 35 216592013527 11 probable transmembrane helices predicted for EC042_2669 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 438-460, 470-492, 538-560, 868-890, 897-919, 924-946, 972-994 and 1004-1026 216592013528 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 216592013529 ArsC family; Region: ArsC; pfam03960 216592013530 putative catalytic residues [active] 216592013531 HMMPfam hit to PF03960, ArsC family, score 1.5e-48 216592013532 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 216592013533 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 216592013534 metal binding site [ion binding]; metal-binding site 216592013535 dimer interface [polypeptide binding]; other site 216592013536 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216592013537 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2.1e-41 216592013538 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 216592013539 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 9.2e-35 216592013540 hypothetical protein; Provisional; Region: PRK13664 216592013541 1 probable transmembrane helix predicted for EC042_2673 by TMHMM2.0 at aa 15-32 216592013542 putative hydrolase; Provisional; Region: PRK11460 216592013543 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 216592013544 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 1.4e-79 216592013545 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 216592013546 Helicase; Region: Helicase_RecD; pfam05127 216592013547 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 216592013548 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 216592013549 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.0049 216592013550 HMMPfam hit to PF05127, Putative ATPase (DUF699), score 1.7e-68 216592013551 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013552 Predicted metalloprotease [General function prediction only]; Region: COG2321 216592013553 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 216592013554 HMMPfam hit to PF04228, Putative neutral zinc metallopeptidase, score 7e-206 216592013555 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592013556 1 probable transmembrane helix predicted for EC042_2676 by TMHMM2.0 at aa 38-60 216592013557 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 216592013558 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 216592013559 ATP binding site [chemical binding]; other site 216592013560 active site 216592013561 substrate binding site [chemical binding]; other site 216592013562 HMMPfam hit to PF01259, SAICAR synthetase, score 1.1e-128 216592013563 PS01058 SAICAR synthetase signature 2. 216592013564 PS01057 SAICAR synthetase signature 1. 216592013565 lipoprotein; Provisional; Region: PRK11679 216592013566 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 216592013567 HMMPfam hit to PF06804, NlpB/DapX lipoprotein, score 4.4e-209 216592013568 PS00572 Glycosyl hydrolases family 1 active site. 216592013569 Signal peptide predicted for EC042_2678 by SignalP 2.0 HMM (Signal peptide probability 0.776) with cleavage site probability 0.234 between residues 27 and 28 216592013570 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013571 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216592013572 dihydrodipicolinate synthase; Region: dapA; TIGR00674 216592013573 dimer interface [polypeptide binding]; other site 216592013574 active site 216592013575 catalytic residue [active] 216592013576 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 5.3e-179 216592013577 PS00666 Dihydrodipicolinate synthetase signature 2. 216592013578 PS00665 Dihydrodipicolinate synthetase signature 1. 216592013579 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 216592013580 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 216592013581 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216592013582 HMMPfam hit to PF01842, ACT domain, score 0.01 216592013583 HMMPfam hit to PF01842, ACT domain, score 8.6e-07 216592013584 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216592013585 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 216592013586 catalytic triad [active] 216592013587 HMMPfam hit to PF00578, AhpC/TSA family, score 5.2e-66 216592013588 Present in 0157, absent in Uropathogenic, anaerobic respiration operon (Hydrogenase 4 and Formate hydrogenlyase, regulator) 216592013589 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 216592013590 4Fe-4S binding domain; Region: Fer4; pfam00037 216592013591 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.2e-09 216592013592 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592013593 hydrogenase 4 subunit B; Validated; Region: PRK06521 216592013594 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592013595 16 probable transmembrane helices predicted for EC042_2683 by TMHMM2.0 at aa 5-27, 40-62, 82-101, 108-130, 134-153, 165-187, 202-224, 237-259, 274-296, 303-325, 340-362, 383-405, 431-453, 474-496, 529-551 and 654-671 216592013596 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 2e-44 216592013597 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 216592013598 NADH dehydrogenase; Region: NADHdh; cl00469 216592013599 HMMPfam hit to PF00146, NADH dehydrogenase, score 6.8e-36 216592013600 8 probable transmembrane helices predicted for EC042_2684 by TMHMM2.0 at aa 16-38, 81-103, 108-130, 145-167, 180-202, 236-258, 265-287 and 297-319 216592013601 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 216592013602 hydrogenase 4 subunit D; Validated; Region: PRK06525 216592013603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592013604 Signal peptide predicted for EC042_2685 by SignalP 2.0 HMM (Signal peptide probability 0.977) with cleavage site probability 0.948 between residues 27 and 28 216592013605 13 probable transmembrane helices predicted for EC042_2685 by TMHMM2.0 at aa 4-23, 30-52, 72-94, 115-137, 169-188, 208-230, 240-262, 267-289, 299-321, 328-350, 370-392, 399-421 and 456-478 216592013606 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 3.9e-47 216592013607 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 216592013608 Signal peptide predicted for EC042_2686 by SignalP 2.0 HMM (Signal peptide probability 0.736) with cleavage site probability 0.559 between residues 53 and 54 216592013609 7 probable transmembrane helices predicted for EC042_2686 by TMHMM2.0 at aa 5-24, 31-53, 57-79, 92-114, 118-140, 152-171 and 176-195 216592013610 HMMPfam hit to PF00420, NADH-ubiquinone/plastoquinone oxidoreduct, score 6.5e-12 216592013611 hydrogenase 4 subunit F; Validated; Region: PRK06458 216592013612 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592013613 Signal peptide predicted for EC042_2687 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.985 between residues 23 and 24 216592013614 12 probable transmembrane helices predicted for EC042_2687 by TMHMM2.0 at aa 5-22, 35-54, 74-96, 117-139, 168-190, 216-238, 253-275, 288-307, 322-344, 372-394, 414-436 and 457-479 216592013615 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 1.5e-50 216592013616 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 216592013617 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 216592013618 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 216592013619 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 7.9e-26 216592013620 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 216592013621 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 3.9e-15 216592013622 hydrogenase 4 subunit H; Validated; Region: PRK08222 216592013623 4Fe-4S binding domain; Region: Fer4; pfam00037 216592013624 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.6e-05 216592013625 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592013626 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.6e-07 216592013627 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592013628 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 216592013629 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 6.3e-45 216592013630 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 216592013631 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 216592013632 HMMPfam hit to PF07450, Formate hydrogenlyase maturation protein Hyc, score 8.4e-70 216592013633 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 216592013634 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592013635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592013636 Walker A motif; other site 216592013637 ATP binding site [chemical binding]; other site 216592013638 Walker B motif; other site 216592013639 arginine finger; other site 216592013640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592013641 HMMPfam hit to PF01590, GAF domain, score 8.8e-13 216592013642 PS00134 Serine proteases, trypsin family, histidine active site. 216592013643 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 6.1e-161 216592013644 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592013645 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592013646 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592013647 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2.2e-09 216592013648 putative formate transporter; Provisional; Region: focB; PRK09713 216592013649 Signal peptide predicted for EC042_2693 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.487 between residues 57 and 58 216592013650 HMMPfam hit to PF01226, Formate/nitrite transporter, score 7.4e-165 216592013651 6 probable transmembrane helices predicted for EC042_2693 by TMHMM2.0 at aa 31-53, 68-90, 111-133, 165-187, 200-222 and 249-271 216592013652 PS01005 Formate and nitrite transporters signature 1. 216592013653 PS01006 Formate and nitrite transporters signature 2. 216592013654 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216592013655 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216592013656 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.2e-107 216592013657 7 probable transmembrane helices predicted for EC042_2694 by TMHMM2.0 at aa 20-51, 72-94, 155-177, 217-236, 251-273, 278-300 and 310-332 216592013658 Signal peptide predicted for EC042_2694 by SignalP 2.0 HMM (Signal peptide probability 0.729) with cleavage site probability 0.281 between residues 49 and 50 216592013659 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 216592013660 Peptidase family M48; Region: Peptidase_M48; cl12018 216592013661 Signal peptide predicted for EC042_2695 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.992 between residues 27 and 28 216592013662 HMMPfam hit to PF01435, Peptidase family M48, score 4.4e-28 216592013663 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.35 216592013664 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.7 216592013665 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216592013666 ArsC family; Region: ArsC; pfam03960 216592013667 catalytic residues [active] 216592013668 HMMPfam hit to PF03960, ArsC family, score 1.1e-50 216592013669 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 216592013670 DNA replication initiation factor; Provisional; Region: PRK08084 216592013671 uracil transporter; Provisional; Region: PRK10720 216592013672 11 probable transmembrane helices predicted for EC042_2698 by TMHMM2.0 at aa 52-74, 79-101, 105-122, 135-157, 172-194, 199-221, 241-263, 318-340, 345-367, 379-401 and 406-425 216592013673 HMMPfam hit to PF00860, Permease family, score 5e-145 216592013674 PS01116 Xanthine/uracil permeases family signature. 216592013675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592013676 active site 216592013677 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 7.9e-13 216592013678 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 216592013679 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 216592013680 dimerization interface [polypeptide binding]; other site 216592013681 putative ATP binding site [chemical binding]; other site 216592013682 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 5.4e-73 216592013683 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.8e-53 216592013684 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 216592013685 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 216592013686 active site 216592013687 substrate binding site [chemical binding]; other site 216592013688 cosubstrate binding site; other site 216592013689 catalytic site [active] 216592013690 HMMPfam hit to PF00551, Formyl transferase, score 1.8e-95 216592013691 PS00373 Phosphoribosylglycinamide formyltransferase active site. 216592013692 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 216592013693 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 216592013694 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 216592013695 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 216592013696 domain interface [polypeptide binding]; other site 216592013697 active site 216592013698 catalytic site [active] 216592013699 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216592013700 putative active site [active] 216592013701 catalytic site [active] 216592013702 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 216592013703 exopolyphosphatase; Provisional; Region: PRK10854 216592013704 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216592013705 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 2.7e-147 216592013706 MASE1; Region: MASE1; pfam05231 216592013707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216592013708 diguanylate cyclase; Region: GGDEF; smart00267 216592013709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592013710 HMMPfam hit to PF00563, EAL domain, score 1.6e-105 216592013711 HMMPfam hit to PF05231, MASE1, score 1.1e-82 216592013712 9 probable transmembrane helices predicted for EC042_2704 by TMHMM2.0 at aa 15-36, 43-65, 80-102, 129-151, 166-188, 216-235, 240-259, 266-285 and 295-317 216592013713 Signal peptide predicted for EC042_2704 by SignalP 2.0 HMM (Signal peptide probability 0.991) with cleavage site probability 0.879 between residues 63 and 64 216592013714 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 216592013715 Signal peptide predicted for EC042_2706 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.710 between residues 26 and 27 216592013716 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013717 Signal peptide predicted for EC042_2707 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.748 between residues 19 and 20 216592013718 GMP synthase; Reviewed; Region: guaA; PRK00074 216592013719 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 216592013720 AMP/PPi binding site [chemical binding]; other site 216592013721 candidate oxyanion hole; other site 216592013722 catalytic triad [active] 216592013723 potential glutamine specificity residues [chemical binding]; other site 216592013724 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 216592013725 ATP Binding subdomain [chemical binding]; other site 216592013726 Ligand Binding sites [chemical binding]; other site 216592013727 Dimerization subdomain; other site 216592013728 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 3.8e-74 216592013729 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.7e-52 216592013730 PS00442 Glutamine amidotransferases class-I active site. 216592013731 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 216592013732 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216592013733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 216592013734 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216592013735 active site 216592013736 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 5.4e-207 216592013737 PS00487 IMP dehydrogenase / GMP reductase signature. 216592013738 HMMPfam hit to PF00571, CBS domain, score 2.1e-11 216592013739 HMMPfam hit to PF00571, CBS domain, score 1.3e-11 216592013740 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 216592013741 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 216592013742 generic binding surface II; other site 216592013743 generic binding surface I; other site 216592013744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216592013745 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.8e-14 216592013746 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 1e-103 216592013747 Present in Uropathogenic, absent in 0157. carries three outer membrane proteins similar to proteins on CS54 island of Salmonella enterica serotype typhimurium 216592013748 RatA-like protein; Provisional; Region: PRK15316 216592013749 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013750 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013751 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013752 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013753 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013754 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013755 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013756 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013757 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013758 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013759 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013760 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013761 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013762 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013763 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013764 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013765 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 216592013766 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 216592013767 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 1.6e-43 216592013768 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 5.9e-17 216592013769 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 5.1e-63 216592013770 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 4.5e-05 216592013771 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 4.1e-66 216592013772 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 2.4e-09 216592013773 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 1.6e-65 216592013774 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 1.6e-11 216592013775 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 4.2e-58 216592013776 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 2.1e-15 216592013777 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 4.3e-78 216592013778 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 3e-12 216592013779 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 1.6e-67 216592013780 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 2.2e-06 216592013781 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 7.3e-61 216592013782 HMMPfam hit to PF05689, Salmonella repeat of unknown function (DUF82, score 5.5e-56 216592013783 HMMPfam hit to PF05688, Salmonella repeat of unknown function (DUF82, score 5.2e-19 216592013784 Signal peptide predicted for EC042_2711 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.859 between residues 26 and 27 216592013785 intimin-like protein SinH; Provisional; Region: PRK15318 216592013786 Signal peptide predicted for EC042_2712 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 29 and 30 216592013787 1 probable transmembrane helix predicted for EC042_2712 by TMHMM2.0 at aa 12-29 216592013788 intimin-like protein SinH; Provisional; Region: PRK15318 216592013789 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 216592013790 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592013791 Signal peptide predicted for EC042_2713 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.998 between residues 29 and 30 216592013792 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 216592013793 HMMPfam hit to PF07191, Protein of unknown function (DUF1407), score 2.7e-50 216592013794 GTP-binding protein Der; Reviewed; Region: PRK00093 216592013795 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 216592013796 G1 box; other site 216592013797 GTP/Mg2+ binding site [chemical binding]; other site 216592013798 Switch I region; other site 216592013799 G2 box; other site 216592013800 Switch II region; other site 216592013801 G3 box; other site 216592013802 G4 box; other site 216592013803 G5 box; other site 216592013804 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 216592013805 G1 box; other site 216592013806 GTP/Mg2+ binding site [chemical binding]; other site 216592013807 Switch I region; other site 216592013808 G2 box; other site 216592013809 G3 box; other site 216592013810 Switch II region; other site 216592013811 G4 box; other site 216592013812 G5 box; other site 216592013813 HMMPfam hit to PF01926, GTPase of unknown function, score 1.7e-44 216592013814 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013815 HMMPfam hit to PF01926, GTPase of unknown function, score 6.8e-48 216592013816 PS00017 ATP/GTP-binding site motif A (P-loop). 216592013817 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 216592013818 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 216592013819 Trp docking motif [polypeptide binding]; other site 216592013820 active site 216592013821 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1.4e-06 216592013822 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1.2e-06 216592013823 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2e-06 216592013824 Signal peptide predicted for EC042_2716 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.739 between residues 24 and 25 216592013825 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 216592013827 1 probable transmembrane helix predicted for EC042_2717 by TMHMM2.0 at aa 24-43 216592013828 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 216592013829 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 216592013830 dimer interface [polypeptide binding]; other site 216592013831 motif 1; other site 216592013832 active site 216592013833 motif 2; other site 216592013834 motif 3; other site 216592013835 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 216592013836 anticodon binding site; other site 216592013837 HMMPfam hit to PF03129, Anticodon binding domain, score 4.1e-18 216592013838 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592013839 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1e-50 216592013840 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 216592013841 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216592013842 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216592013843 HMMPfam hit to PF04551, GcpE protein, score 7.5e-261 216592013844 cytoskeletal protein RodZ; Provisional; Region: PRK10856 216592013845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592013846 non-specific DNA binding site [nucleotide binding]; other site 216592013847 salt bridge; other site 216592013848 sequence-specific DNA binding site [nucleotide binding]; other site 216592013849 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 216592013850 1 probable transmembrane helix predicted for EC042_2720 by TMHMM2.0 at aa 111-133 216592013851 HMMPfam hit to PF01381, Helix-turn-helix, score 6.8e-07 216592013852 Predicted helix-turn-helix motif with score 1707.000, SD 5.00 at aa 28-49, sequence LSQQAVAERLCLKVSTVRDIEE 216592013853 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 216592013854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592013855 FeS/SAM binding site; other site 216592013856 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.6e-19 216592013857 Signal peptide predicted for EC042_2722 by SignalP 2.0 HMM (Signal peptide probability 0.959) with cleavage site probability 0.959 between residues 22 and 23 216592013858 penicillin-binding protein 1C; Provisional; Region: PRK11240 216592013859 Transglycosylase; Region: Transgly; pfam00912 216592013860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216592013861 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 216592013862 HMMPfam hit to PF06832, Penicillin-Binding Protein C-terminus, score 2.3e-33 216592013863 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.8e-09 216592013864 HMMPfam hit to PF00912, Transglycosylase, score 1.4e-80 216592013865 1 probable transmembrane helix predicted for EC042_2723 by TMHMM2.0 at aa 9-28 216592013866 Signal peptide predicted for EC042_2723 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.985 between residues 27 and 28 216592013867 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 216592013868 MG2 domain; Region: A2M_N; pfam01835 216592013869 Alpha-2-macroglobulin family; Region: A2M; pfam00207 216592013870 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 216592013871 surface patch; other site 216592013872 thioester region; other site 216592013873 specificity defining residues; other site 216592013874 HMMPfam hit to PF07703, Alpha-2-macroglobulin family N-terminal regi, score 4.7e-37 216592013875 PS00215 Mitochondrial energy transfer proteins signature. 216592013876 HMMPfam hit to PF01835, Alpha-2-macroglobulin family N-terminal regi, score 7.3e-86 216592013877 Signal peptide predicted for EC042_2724 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.468 between residues 21 and 22 216592013878 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592013879 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 216592013880 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216592013881 active site residue [active] 216592013882 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216592013883 active site residue [active] 216592013884 HMMPfam hit to PF00581, Rhodanese-like domain, score 2.9e-40 216592013885 PS00380 Rhodanese signature 1. 216592013886 HMMPfam hit to PF00581, Rhodanese-like domain, score 4e-31 216592013887 PS00683 Rhodanese C-terminal signature. 216592013888 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 216592013889 HMMPfam hit to PF07179, SseB protein, score 4.4e-213 216592013890 aminopeptidase B; Provisional; Region: PRK05015 216592013891 Peptidase; Region: DUF3663; pfam12404 216592013892 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 216592013893 interface (dimer of trimers) [polypeptide binding]; other site 216592013894 Substrate-binding/catalytic site; other site 216592013895 Zn-binding sites [ion binding]; other site 216592013896 HMMPfam hit to PF00883, Cytosol aminopeptidase family, catalyti, score 1.2e-183 216592013897 PS00631 Cytosol aminopeptidase signature. 216592013898 hypothetical protein; Provisional; Region: PRK10721 216592013899 HMMPfam hit to PF04384, Protein of unknown function (DUF528), score 2.4e-47 216592013900 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216592013901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592013902 catalytic loop [active] 216592013903 iron binding site [ion binding]; other site 216592013904 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 8.4e-24 216592013905 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 216592013906 chaperone protein HscA; Provisional; Region: hscA; PRK05183 216592013907 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 216592013908 nucleotide binding site [chemical binding]; other site 216592013909 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216592013910 SBD interface [polypeptide binding]; other site 216592013911 HMMPfam hit to PF00012, Hsp70 protein, score 9.4e-289 216592013912 PS01036 Heat shock hsp70 proteins family signature 3. 216592013913 PS00329 Heat shock hsp70 proteins family signature 2. 216592013914 PS00297 Heat shock hsp70 proteins family signature 1. 216592013915 co-chaperone HscB; Provisional; Region: hscB; PRK05014 216592013916 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216592013917 HSP70 interaction site [polypeptide binding]; other site 216592013918 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 216592013919 HMMPfam hit to PF07743, HSCB C-terminal oligomerisation domain, score 1.7e-33 216592013920 HMMPfam hit to PF00226, DnaJ domain, score 5.1e-11 216592013921 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 216592013922 HMMPfam hit to PF01521, HesB-like domain, score 2.6e-59 216592013923 PS01152 Hypothetical hesB/yadR/yfhF family signature. 216592013924 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 216592013925 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 216592013926 trimerization site [polypeptide binding]; other site 216592013927 active site 216592013928 cysteine desulfurase; Provisional; Region: PRK14012 216592013929 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 216592013930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592013931 catalytic residue [active] 216592013932 HMMPfam hit to PF00266, Aminotransferase class-V, score 6.7e-124 216592013933 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216592013934 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 216592013935 Rrf2 family protein; Region: rrf2_super; TIGR00738 216592013936 HMMPfam hit to PF02082, Transcriptional regulator, score 6.6e-49 216592013937 PS01332 Uncharacterized protein family UPF0074 signature. 216592013938 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 26-47, sequence VPLADISERQGISLSYLEQLFS 216592013939 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 216592013940 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 216592013941 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.2e-29 216592013942 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216592013943 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 216592013944 active site 216592013945 dimerization interface [polypeptide binding]; other site 216592013946 HMMPfam hit to PF00459, Inositol monophosphatase family, score 4.9e-118 216592013947 PS00629 Inositol monophosphatase family signature 1. 216592013948 PS00630 Inositol monophosphatase family signature 2. 216592013949 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216592013950 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216592013951 1 probable transmembrane helix predicted for EC042_2738 by TMHMM2.0 at aa 12-31 216592013952 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 216592013953 PRD domain; Region: PRD; pfam00874 216592013954 PRD domain; Region: PRD; pfam00874 216592013955 HMMPfam hit to PF00874, PRD domain, score 7.8e-16 216592013956 HMMPfam hit to PF00874, PRD domain, score 1.2e-15 216592013957 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 216592013958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592013959 putative substrate translocation pore; other site 216592013960 HMMPfam hit to PF01306, LacY proton/sugar symporter, score 1.5e-06 216592013961 12 probable transmembrane helices predicted for EC042_2740 by TMHMM2.0 at aa 9-31, 41-63, 70-89, 93-111, 132-154, 158-180, 207-229, 234-256, 269-288, 293-315, 328-350 and 354-371 216592013962 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.4e-17 216592013963 Present in 0157, absent in Uropathogenic, 3-phenylpropionic acid catabolism operon 216592013964 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216592013965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592013966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592013967 dimerization interface [polypeptide binding]; other site 216592013968 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.5e-52 216592013969 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-20 216592013970 PS00044 Bacterial regulatory proteins, lysR family signature. 216592013971 Predicted helix-turn-helix motif with score 1753.000, SD 5.16 at aa 38-59, sequence LNFTRAAEKLHTSQPSLSSQIR 216592013972 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216592013973 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 216592013974 iron-sulfur cluster [ion binding]; other site 216592013975 [2Fe-2S] cluster binding site [ion binding]; other site 216592013976 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 216592013977 beta subunit interface [polypeptide binding]; other site 216592013978 alpha subunit interface [polypeptide binding]; other site 216592013979 active site 216592013980 substrate binding site [chemical binding]; other site 216592013981 Fe binding site [ion binding]; other site 216592013982 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 5.5e-37 216592013983 PS00570 Bacterial ring hydroxylating dioxygenases alpha-subunit signature. 216592013984 HMMPfam hit to PF00848, Ring hydroxylating alpha subunit (cat, score 3.4e-160 216592013985 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 216592013986 inter-subunit interface; other site 216592013987 HMMPfam hit to PF00866, Ring hydroxylating beta subunit, score 2.8e-67 216592013988 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 216592013989 [2Fe-2S] cluster binding site [ion binding]; other site 216592013990 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 2.5e-26 216592013991 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 216592013992 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 216592013993 NAD binding site [chemical binding]; other site 216592013994 active site 216592013995 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.8e-47 216592013996 PS00061 Short-chain dehydrogenases/reductases family signature. 216592013997 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216592013998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592013999 Signal peptide predicted for EC042_2746 by SignalP 2.0 HMM (Signal peptide probability 0.945) with cleavage site probability 0.764 between residues 18 and 19 216592014000 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 2.3e-80 216592014001 Predicted membrane protein [Function unknown]; Region: COG2259 216592014002 4 probable transmembrane helices predicted for EC042_2747 by TMHMM2.0 at aa 30-49, 69-91, 96-115 and 135-152 216592014003 HMMPfam hit to PF07681, DoxX, score 2.8e-39 216592014004 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 216592014005 active site 216592014006 catalytic residues [active] 216592014007 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.7e-61 216592014008 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592014009 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 216592014010 putative NAD(P) binding site [chemical binding]; other site 216592014011 catalytic Zn binding site [ion binding]; other site 216592014012 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.5e-98 216592014013 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592014014 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592014015 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592014016 TM-ABC transporter signature motif; other site 216592014017 8 probable transmembrane helices predicted for EC042_2750 by TMHMM2.0 at aa 27-49, 61-83, 103-125, 127-149, 169-191, 224-246, 278-300 and 307-324 216592014018 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1e-56 216592014019 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216592014020 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592014021 Walker A/P-loop; other site 216592014022 ATP binding site [chemical binding]; other site 216592014023 Q-loop/lid; other site 216592014024 ABC transporter signature motif; other site 216592014025 Walker B; other site 216592014026 D-loop; other site 216592014027 H-loop/switch region; other site 216592014028 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592014029 HMMPfam hit to PF00005, ABC transporter, score 5.1e-27 216592014030 PS00211 ABC transporters family signature. 216592014031 HMMPfam hit to PF00005, ABC transporter, score 3.8e-43 216592014032 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014033 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216592014034 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216592014035 ligand binding site [chemical binding]; other site 216592014036 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.012 216592014037 Signal peptide predicted for EC042_2752 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.986 between residues 26 and 27 216592014038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592014039 TPR motif; other site 216592014040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216592014041 binding surface 216592014042 TPR repeat; Region: TPR_11; pfam13414 216592014043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592014044 TPR motif; other site 216592014045 binding surface 216592014046 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.31 216592014047 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0075 216592014048 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.0043 216592014049 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 3.3 216592014050 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216592014051 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216592014052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592014053 nucleotide binding site [chemical binding]; other site 216592014054 Predicted helix-turn-helix motif with score 1162.000, SD 3.14 at aa 28-49, sequence ANKSTLARLAQISIPAVSNILQ 216592014055 HMMPfam hit to PF00480, ROK family, score 6e-14 216592014056 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216592014057 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 216592014058 dimer interface [polypeptide binding]; other site 216592014059 active site 216592014060 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216592014061 folate binding site [chemical binding]; other site 216592014062 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 7e-293 216592014063 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 216592014064 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 216592014065 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 216592014066 heme-binding site [chemical binding]; other site 216592014067 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 216592014068 FAD binding pocket [chemical binding]; other site 216592014069 FAD binding motif [chemical binding]; other site 216592014070 phosphate binding motif [ion binding]; other site 216592014071 beta-alpha-beta structure motif; other site 216592014072 NAD binding pocket [chemical binding]; other site 216592014073 Heme binding pocket [chemical binding]; other site 216592014074 HMMPfam hit to PF00042, Globin, score 6.9e-28 216592014075 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 7e-09 216592014076 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.6e-30 216592014077 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 216592014078 Nitrogen regulatory protein P-II; Region: P-II; smart00938 216592014079 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 5.5e-70 216592014080 PS00638 P-II protein C-terminal region signature. 216592014081 PS00496 P-II protein urydylation site. 216592014082 response regulator GlrR; Provisional; Region: PRK15115 216592014083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592014084 active site 216592014085 phosphorylation site [posttranslational modification] 216592014086 intermolecular recognition site; other site 216592014087 dimerization interface [polypeptide binding]; other site 216592014088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592014089 Walker A motif; other site 216592014090 ATP binding site [chemical binding]; other site 216592014091 Walker B motif; other site 216592014092 arginine finger; other site 216592014093 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592014094 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.8e-149 216592014095 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592014096 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592014097 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.5e-46 216592014098 hypothetical protein; Provisional; Region: PRK10722 216592014099 Signal peptide predicted for EC042_2759 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.951 between residues 33 and 34 216592014100 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216592014102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592014103 dimer interface [polypeptide binding]; other site 216592014104 phosphorylation site [posttranslational modification] 216592014105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592014106 ATP binding site [chemical binding]; other site 216592014107 Mg2+ binding site [ion binding]; other site 216592014108 G-X-G motif; other site 216592014109 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-28 216592014110 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.4e-20 216592014111 HMMPfam hit to PF00672, HAMP domain, score 5.4e-10 216592014112 2 probable transmembrane helices predicted for EC042_2760 by TMHMM2.0 at aa 35-52 and 196-218 216592014113 Signal peptide predicted for EC042_2760 by SignalP 2.0 HMM (Signal peptide probability 0.941) with cleavage site probability 0.510 between residues 51 and 52 216592014114 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 216592014115 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 216592014116 dimerization interface [polypeptide binding]; other site 216592014117 ATP binding site [chemical binding]; other site 216592014118 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 216592014119 dimerization interface [polypeptide binding]; other site 216592014120 ATP binding site [chemical binding]; other site 216592014121 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 216592014122 putative active site [active] 216592014123 catalytic triad [active] 216592014124 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 1.8e-23 216592014125 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 4.4e-34 216592014126 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 7.9e-47 216592014127 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 216592014128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592014129 substrate binding pocket [chemical binding]; other site 216592014130 membrane-bound complex binding site; other site 216592014131 hinge residues; other site 216592014132 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592014133 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592014134 catalytic residue [active] 216592014135 Signal peptide predicted for EC042_2762 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.846 between residues 21 and 22 216592014136 1 probable transmembrane helix predicted for EC042_2762 by TMHMM2.0 at aa 7-29 216592014137 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.5e-12 216592014138 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 4.9e-41 216592014139 PS00922 Prokaryotic transglycosylases signature. 216592014140 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216592014141 nucleoside/Zn binding site; other site 216592014142 dimer interface [polypeptide binding]; other site 216592014143 catalytic motif [active] 216592014144 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 6.1e-44 216592014145 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216592014146 hypothetical protein; Provisional; Region: PRK11590 216592014147 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216592014148 1 probable transmembrane helix predicted for EC042_2764 by TMHMM2.0 at aa 35-54 216592014149 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216592014150 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 216592014151 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216592014152 putative active site [active] 216592014153 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 5e-57 216592014154 Predicted helix-turn-helix motif with score 1149.000, SD 3.10 at aa 59-80, sequence LSSQQLANEAGVSQSSVVKFAQ 216592014155 HMMPfam hit to PF01380, SIS domain, score 1.3e-35 216592014156 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 216592014157 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.8e-05 216592014158 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592014159 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 216592014160 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 5e-13 216592014161 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 216592014162 active site 216592014163 hydrophilic channel; other site 216592014164 dimerization interface [polypeptide binding]; other site 216592014165 catalytic residues [active] 216592014166 active site lid [active] 216592014167 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 3.6e-151 216592014168 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 216592014169 Recombination protein O N terminal; Region: RecO_N; pfam11967 216592014170 Recombination protein O C terminal; Region: RecO_C; pfam02565 216592014171 HMMPfam hit to PF02565, Recombination protein O, score 9.7e-112 216592014172 GTPase Era; Reviewed; Region: era; PRK00089 216592014173 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 216592014174 G1 box; other site 216592014175 GTP/Mg2+ binding site [chemical binding]; other site 216592014176 Switch I region; other site 216592014177 G2 box; other site 216592014178 Switch II region; other site 216592014179 G3 box; other site 216592014180 G4 box; other site 216592014181 G5 box; other site 216592014182 KH domain; Region: KH_2; pfam07650 216592014183 HMMPfam hit to PF07650, KH domain, score 9.9e-26 216592014184 HMMPfam hit to PF01926, GTPase of unknown function, score 3.1e-38 216592014185 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014186 ribonuclease III; Reviewed; Region: rnc; PRK00102 216592014187 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 216592014188 dimerization interface [polypeptide binding]; other site 216592014189 active site 216592014190 metal binding site [ion binding]; metal-binding site 216592014191 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 216592014192 dsRNA binding site [nucleotide binding]; other site 216592014193 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 1.9e-24 216592014194 HMMPfam hit to PF00636, RNase3 domain, score 1.1e-48 216592014195 PS00517 Ribonuclease III family signature. 216592014196 signal peptidase I; Provisional; Region: PRK10861 216592014197 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216592014198 Catalytic site [active] 216592014199 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216592014200 PS00761 Signal peptidases I signature 3. 216592014201 HMMPfam hit to PF00717, Peptidase S24-like, score 6.2e-25 216592014202 PS00760 Signal peptidases I lysine active site. 216592014203 PS00501 Signal peptidases I serine active site. 216592014204 2 probable transmembrane helices predicted for EC042_2772 by TMHMM2.0 at aa 5-27 and 60-82 216592014205 GTP-binding protein LepA; Provisional; Region: PRK05433 216592014206 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 216592014207 G1 box; other site 216592014208 putative GEF interaction site [polypeptide binding]; other site 216592014209 GTP/Mg2+ binding site [chemical binding]; other site 216592014210 Switch I region; other site 216592014211 G2 box; other site 216592014212 G3 box; other site 216592014213 Switch II region; other site 216592014214 G4 box; other site 216592014215 G5 box; other site 216592014216 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 216592014217 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 216592014218 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 216592014219 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 1.5e-80 216592014220 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 7.9e-32 216592014221 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.4e-11 216592014222 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.8e-74 216592014223 PS00301 GTP-binding elongation factors signature. 216592014224 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014225 SoxR reducing system protein RseC; Provisional; Region: PRK10862 216592014226 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 1.7e-75 216592014227 2 probable transmembrane helices predicted for EC042_2774 by TMHMM2.0 at aa 73-95 and 99-121 216592014228 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 216592014229 anti-sigma E factor; Provisional; Region: rseB; PRK09455 216592014230 HMMPfam hit to PF03888, MucB/RseB family, score 4.4e-216 216592014231 Signal peptide predicted for EC042_2775 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.911 between residues 23 and 24 216592014232 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 216592014233 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 216592014234 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 216592014235 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal domain, score 4.5e-29 216592014236 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal domain, score 4.5e-57 216592014237 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 216592014238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592014239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592014240 DNA binding residues [nucleotide binding] 216592014241 HMMPfam hit to PF04545, Sigma-70, region, score 5e-16 216592014242 Predicted helix-turn-helix motif with score 1179.000, SD 3.20 at aa 154-175, sequence LSYEEIAAIMDCPVGTVRSRIF 216592014243 HMMPfam hit to PF04542, Sigma-70 region, score 8.4e-22 216592014244 PS01063 Sigma-70 factors ECF subfamily signature. 216592014245 L-aspartate oxidase; Provisional; Region: PRK09077 216592014246 L-aspartate oxidase; Provisional; Region: PRK06175 216592014247 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216592014248 HMMPfam hit to PF00890, FAD binding domain, score 5.1e-169 216592014249 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 1.1e-10 216592014250 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 216592014251 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216592014252 PS00092 N-6 Adenine-specific DNA methylases signature. 216592014253 Predicted helix-turn-helix motif with score 1333.000, SD 3.73 at aa 151-172, sequence INQSPWAERINVHTADIQQWIT 216592014254 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 216592014255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216592014256 ATP binding site [chemical binding]; other site 216592014257 Mg++ binding site [ion binding]; other site 216592014258 motif III; other site 216592014259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592014260 nucleotide binding region [chemical binding]; other site 216592014261 ATP-binding site [chemical binding]; other site 216592014262 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 7.2e-69 216592014263 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014264 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592014265 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.3e-31 216592014266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592014267 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592014268 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592014269 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 23-44, sequence AGIISTAKLFQLSHTSLSHWIN 216592014270 HTH-like domain; Region: HTH_21; pfam13276 216592014271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592014272 Integrase core domain; Region: rve; pfam00665 216592014273 Integrase core domain; Region: rve_2; pfam13333 216592014274 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014275 HMMPfam hit to PF00665, Integrase core domain, score 7.6e-45 216592014276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592014277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592014278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216592014279 dimerization interface [polypeptide binding]; other site 216592014280 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.3e-47 216592014281 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.9e-15 216592014282 PS00044 Bacterial regulatory proteins, lysR family signature. 216592014283 Predicted helix-turn-helix motif with score 1361.000, SD 3.82 at aa 31-52, sequence GSFLRASQKLCCTQSTVTFHIQ 216592014284 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 216592014285 6 probable transmembrane helices predicted for EC042_2784 by TMHMM2.0 at aa 10-32, 44-66, 70-92, 105-127, 142-164 and 177-194 216592014286 HMMPfam hit to PF01810, LysE type translocator, score 4.1e-06 216592014287 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 216592014288 HMMPfam hit to PF01228, Glycine radical, score 7.2e-52 216592014289 PS00850 Glycine radical signature. 216592014290 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 216592014291 ligand binding site [chemical binding]; other site 216592014292 active site 216592014293 UGI interface [polypeptide binding]; other site 216592014294 catalytic site [active] 216592014295 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 1.9e-86 216592014296 PS00130 Uracil-DNA glycosylase signature. 216592014297 putative methyltransferase; Provisional; Region: PRK10864 216592014298 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 216592014299 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216592014300 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 5.7e-59 216592014301 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014302 thioredoxin 2; Provisional; Region: PRK10996 216592014303 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 216592014304 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216592014305 catalytic residues [active] 216592014306 HMMPfam hit to PF00085, Thioredoxin, score 6.1e-37 216592014307 PS00194 Thioredoxin family active site. 216592014308 Uncharacterized conserved protein [Function unknown]; Region: COG3148 216592014309 HMMPfam hit to PF03942, DTW domain, score 9.8e-94 216592014310 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 216592014311 CoA binding domain; Region: CoA_binding_2; pfam13380 216592014312 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 216592014313 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 216592014314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216592014315 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216592014316 HMMPfam hit to PF02629, CoA binding domain, score 1.7e-06 216592014317 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-14 216592014318 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 216592014319 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 216592014320 domain interface [polypeptide binding]; other site 216592014321 putative active site [active] 216592014322 catalytic site [active] 216592014323 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 216592014324 domain interface [polypeptide binding]; other site 216592014325 putative active site [active] 216592014326 catalytic site [active] 216592014327 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.8e-05 216592014328 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 3.5e-08 216592014329 lipoprotein; Provisional; Region: PRK10759 216592014330 Signal peptide predicted for EC042_2792 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.755 between residues 18 and 19 216592014331 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014332 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 216592014333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592014334 putative substrate translocation pore; other site 216592014335 HMMPfam hit to PF00083, Sugar (and other) transporter, score 3.2e-106 216592014336 12 probable transmembrane helices predicted for EC042_2793 by TMHMM2.0 at aa 21-43, 62-84, 96-113, 118-140, 160-182, 197-214, 244-266, 281-303, 310-327, 337-359, 372-394 and 404-423 216592014337 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-16 216592014338 PS00216 Sugar transport proteins signature 1. 216592014339 PS00217 Sugar transport proteins signature 2. 216592014340 protein disaggregation chaperone; Provisional; Region: PRK10865 216592014341 Clp amino terminal domain; Region: Clp_N; pfam02861 216592014342 Clp amino terminal domain; Region: Clp_N; pfam02861 216592014343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592014344 Walker A motif; other site 216592014345 ATP binding site [chemical binding]; other site 216592014346 Walker B motif; other site 216592014347 arginine finger; other site 216592014348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592014349 Walker A motif; other site 216592014350 ATP binding site [chemical binding]; other site 216592014351 Walker B motif; other site 216592014352 arginine finger; other site 216592014353 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216592014354 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.2e-109 216592014355 PS00871 Chaperonins clpA/B signature 2. 216592014356 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014357 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014358 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 6.4e-12 216592014359 PS00870 Chaperonins clpA/B signature 1. 216592014360 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014361 HMMPfam hit to PF02861, Clp amino terminal domain, score 7.8e-15 216592014362 HMMPfam hit to PF02861, Clp amino terminal domain, score 5.2e-16 216592014363 hypothetical protein; Provisional; Region: PRK10723 216592014364 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 216592014365 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 3.4e-121 216592014366 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 216592014367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592014368 RNA binding surface [nucleotide binding]; other site 216592014369 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216592014370 active site 216592014371 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.6e-69 216592014372 PS01129 Rlu family of pseudouridine synthase signature. 216592014373 HMMPfam hit to PF01479, S4 domain, score 3.7e-14 216592014374 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 216592014375 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 216592014376 Signal peptide predicted for EC042_2797 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.417 between residues 23 and 24 216592014377 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014378 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216592014379 30S subunit binding site; other site 216592014380 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 3.8e-49 216592014381 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 216592014382 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 216592014383 Prephenate dehydratase; Region: PDT; pfam00800 216592014384 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 216592014385 putative L-Phe binding site [chemical binding]; other site 216592014386 HMMPfam hit to PF01817, Chorismate mutase type II, score 1.7e-31 216592014387 HMMPfam hit to PF00800, Prephenate dehydratase, score 6.8e-93 216592014388 PS00857 Prephenate dehydratase signature 1. 216592014389 PS00858 Prephenate dehydratase signature 2. 216592014390 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 216592014391 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 216592014392 prephenate dehydrogenase; Validated; Region: PRK08507 216592014393 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 2.5e-19 216592014394 HMMPfam hit to PF01817, Chorismate mutase type II, score 3e-34 216592014395 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 216592014396 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216592014397 HMMPfam hit to PF00793, DAHP synthetase I family, score 2.6e-173 216592014398 lipoprotein; Provisional; Region: PRK11443 216592014399 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 216592014400 Signal peptide predicted for EC042_2802 by SignalP 2.0 HMM (Signal peptide probability 0.980) with cleavage site probability 0.689 between residues 25 and 26 216592014401 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014402 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014403 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 216592014404 Signal peptide predicted for EC042_2803 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 216592014405 Signal peptide predicted for EC042_2804 by SignalP 2.0 HMM (Signal peptide probability 0.955) with cleavage site probability 0.471 between residues 49 and 50 216592014406 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 216592014407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592014408 metal binding site [ion binding]; metal-binding site 216592014409 active site 216592014410 I-site; other site 216592014411 2 probable transmembrane helices predicted for EC042_2804 by TMHMM2.0 at aa 23-45 and 155-177 216592014412 HMMPfam hit to PF00672, HAMP domain, score 0.0014 216592014413 HMMPfam hit to PF00990, GGDEF domain, score 6.6e-54 216592014414 putative outer membrane lipoprotein; Provisional; Region: PRK09967 216592014415 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592014416 ligand binding site [chemical binding]; other site 216592014417 Signal peptide predicted for EC042_2805 by SignalP 2.0 HMM (Signal peptide probability 0.649) with cleavage site probability 0.218 between residues 18 and 19 216592014418 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014419 HMMPfam hit to PF00691, OmpA family, score 1.1e-44 216592014420 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 216592014421 HMMPfam hit to PF01245, Ribosomal protein L19, score 1.7e-79 216592014422 PS01015 Ribosomal protein L19 signature. 216592014423 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 216592014424 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 1.5e-147 216592014425 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 216592014426 RimM N-terminal domain; Region: RimM; pfam01782 216592014427 PRC-barrel domain; Region: PRC; pfam05239 216592014428 HMMPfam hit to PF05239, PRC-barrel domain, score 1.3e-20 216592014429 HMMPfam hit to PF01782, RimM N-terminal domain, score 4.7e-37 216592014430 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 216592014431 HMMPfam hit to PF00886, Ribosomal protein S16, score 1.4e-35 216592014432 PS00732 Ribosomal protein S16 signature. 216592014433 signal recognition particle protein; Provisional; Region: PRK10867 216592014434 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 216592014435 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216592014436 P loop; other site 216592014437 GTP binding site [chemical binding]; other site 216592014438 Signal peptide binding domain; Region: SRP_SPB; pfam02978 216592014439 HMMPfam hit to PF02978, Signal peptide binding domain, score 2.1e-52 216592014440 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 3.6e-120 216592014441 PS00300 SRP54-type proteins GTP-binding domain signature. 216592014442 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592014443 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014444 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 3.1e-33 216592014445 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 216592014446 Signal peptide predicted for EC042_2811 by SignalP 2.0 HMM (Signal peptide probability 0.858) with cleavage site probability 0.333 between residues 30 and 31 216592014447 8 probable transmembrane helices predicted for EC042_2811 by TMHMM2.0 at aa 24-46, 59-78, 88-110, 115-134, 149-171, 207-226, 236-253 and 262-284 216592014448 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 2.5e-71 216592014449 hypothetical protein; Provisional; Region: PRK11573 216592014450 Domain of unknown function DUF21; Region: DUF21; pfam01595 216592014451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216592014452 Transporter associated domain; Region: CorC_HlyC; smart01091 216592014453 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 3.6e-74 216592014454 4 probable transmembrane helices predicted for EC042_2812 by TMHMM2.0 at aa 4-26, 54-76, 86-104 and 116-138 216592014455 Predicted helix-turn-helix motif with score 1301.000, SD 3.62 at aa 161-182, sequence LSKEELRTIVHESRSQISRRNQ 216592014456 HMMPfam hit to PF00571, CBS domain, score 0.15 216592014457 HMMPfam hit to PF00571, CBS domain, score 2.6e-07 216592014458 HMMPfam hit to PF03471, Transporter associated domain, score 2e-22 216592014459 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 216592014460 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 216592014461 dimer interface [polypeptide binding]; other site 216592014462 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 216592014463 HMMPfam hit to PF01025, GrpE, score 1.1e-76 216592014464 PS01071 grpE protein signature. 216592014465 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 216592014466 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 216592014467 HMMPfam hit to PF01513, ATP-NAD kinase, score 1.4e-106 216592014468 recombination and repair protein; Provisional; Region: PRK10869 216592014469 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216592014470 Walker A/P-loop; other site 216592014471 ATP binding site [chemical binding]; other site 216592014472 Q-loop/lid; other site 216592014473 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216592014474 Q-loop/lid; other site 216592014475 ABC transporter signature motif; other site 216592014476 Walker B; other site 216592014477 D-loop; other site 216592014478 H-loop/switch region; other site 216592014479 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014480 Predicted helix-turn-helix motif with score 1303.000, SD 3.62 at aa 306-327, sequence SKQISLARKHHVSPEALPQYYQ 216592014481 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 216592014482 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 216592014483 Signal peptide predicted for EC042_2816 by SignalP 2.0 HMM (Signal peptide probability 0.992) with cleavage site probability 0.469 between residues 22 and 23 216592014484 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014485 HMMPfam hit to PF04355, SmpA / OmlA family, score 4.4e-42 216592014486 PS00018 EF-hand calcium-binding domain. 216592014487 hypothetical protein; Validated; Region: PRK01777 216592014488 HMMPfam hit to PF03658, Uncharacterised protein family (UPF0125), score 2.9e-57 216592014489 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 216592014490 putative coenzyme Q binding site [chemical binding]; other site 216592014491 PS00036 bZIP transcription factors basic domain signature. 216592014492 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 1.5e-43 216592014493 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 216592014494 SmpB-tmRNA interface; other site 216592014495 HMMPfam hit to PF01668, SmpB protein, score 1.3e-44 216592014496 PS01317 Protein smpB signature. 216592014497 plasmid-like island, inserted next to tmRNA, no flanking repeats, sequence divergence between 0157 and Uropathogenic strains. Carries plasmid replication proteins, H-NS histone family proteins. Similar to a region in Erwinia atroseptica genome 216592014498 integrase; Provisional; Region: PRK09692 216592014499 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592014500 active site 216592014501 Int/Topo IB signature motif; other site 216592014502 HMMPfam hit to PF00589, Phage integrase family, score 4.4e-21 216592014503 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 216592014504 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216592014505 DNA methylase; Region: N6_N4_Mtase; pfam01555 216592014506 HMMPfam hit to PF01555, DNA methylase, score 1.3e-32 216592014507 PS00093 N-4 cytosine-specific DNA methylases signature. 216592014508 Conjugal transfer protein TraD; Region: TraD; cl05753 216592014509 MobA/MobL family; Region: MobA_MobL; pfam03389 216592014510 HMMPfam hit to PF03389, MobA/MobL family, score 4.4e-46 216592014511 5 probable transmembrane helices predicted for EC042_2828 by TMHMM2.0 at aa 4-26, 35-54, 64-86, 99-116 and 131-153 216592014512 Signal peptide predicted for EC042_2829 by SignalP 2.0 HMM (Signal peptide probability 0.746) with cleavage site probability 0.521 between residues 20 and 21 216592014513 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014514 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 216592014515 Signal peptide predicted for EC042_2830 by SignalP 2.0 HMM (Signal peptide probability 0.791) with cleavage site probability 0.302 between residues 24 and 25 216592014516 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014517 Predicted helix-turn-helix motif with score 1044.000, SD 2.74 at aa 50-71, sequence INNQEEAEKKCIEKNRFSRKFK 216592014518 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 216592014519 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 216592014520 HMMPfam hit to PF00816, H-NS histone family, score 5.6e-45 216592014521 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014522 3 probable transmembrane helices predicted for EC042_2835 by TMHMM2.0 at aa 71-93, 106-128 and 143-165 216592014523 2 probable transmembrane helices predicted for EC042_2836 by TMHMM2.0 at aa 28-42 and 46-64 216592014524 1 probable transmembrane helix predicted for EC042_2837 by TMHMM2.0 at aa 12-34 216592014525 Signal peptide predicted for EC042_2837 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.998 between residues 30 and 31 216592014526 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 216592014527 8 probable transmembrane helices predicted for EC042_2838 by TMHMM2.0 at aa 12-34, 61-83, 103-125, 506-528, 535-557, 561-583, 625-644 and 659-681 216592014528 Signal peptide predicted for EC042_2838 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 28 and 29 216592014529 Signal peptide predicted for EC042_2839 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.973 between residues 35 and 36 216592014530 1 probable transmembrane helix predicted for EC042_2839 by TMHMM2.0 at aa 13-35 216592014531 Predicted helix-turn-helix motif with score 1132.000, SD 3.04 at aa 103-124, sequence ISQAKLCRDLDIKKSNMSLVFK 216592014532 PS00018 EF-hand calcium-binding domain. 216592014533 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 216592014534 NIPSNAP; Region: NIPSNAP; pfam07978 216592014535 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592014536 hypothetical protein; Provisional; Region: PRK09945 216592014537 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 216592014538 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592014539 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592014540 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.2e-32 216592014541 HMMPfam hit to PF03212, Pertactin, score 4.6e-74 216592014542 HMMPfam hit to PF05594, no description, score 5.6 216592014543 1 probable transmembrane helix predicted for EC042_2850 by TMHMM2.0 at aa 50-72 216592014545 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 216592014546 active site 216592014547 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216592014548 Ca binding site [ion binding]; other site 216592014549 catalytic site [active] 216592014550 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216592014551 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 4.8e-09 216592014552 HMMPfam hit to PF02806, Alpha amylase, C-terminal all-beta do, score 0.01 216592014553 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 216592014554 substrate binding pocket [chemical binding]; other site 216592014555 active site 216592014556 iron coordination sites [ion binding]; other site 216592014557 Predicted dehydrogenase [General function prediction only]; Region: COG0579 216592014558 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216592014559 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.7e-81 216592014560 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 216592014561 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216592014562 tetramerization interface [polypeptide binding]; other site 216592014563 NAD(P) binding site [chemical binding]; other site 216592014564 catalytic residues [active] 216592014565 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.1e-264 216592014566 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592014567 PS00070 Aldehyde dehydrogenases cysteine active site. 216592014568 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 216592014569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592014570 inhibitor-cofactor binding pocket; inhibition site 216592014571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592014572 catalytic residue [active] 216592014573 HMMPfam hit to PF00202, Aminotransferase class-III, score 6.3e-212 216592014574 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592014575 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 216592014576 HMMPfam hit to PF00324, Amino acid permease, score 4.3e-175 216592014577 12 probable transmembrane helices predicted for EC042_2860 by TMHMM2.0 at aa 40-62, 67-86, 107-129, 144-166, 173-195, 223-245, 266-288, 308-330, 356-378, 383-402, 422-444 and 448-470 216592014578 PS00218 Amino acid permeases signature. 216592014579 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 216592014580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592014581 DNA-binding site [nucleotide binding]; DNA binding site 216592014582 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592014583 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.5e-11 216592014584 PS00043 Bacterial regulatory proteins, gntR family signature. 216592014585 HMMPfam hit to PF07729, FCD domain, score 2.3e-12 216592014586 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 216592014587 bacterial OsmY and nodulation domain; Region: BON; smart00749 216592014588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592014589 HMMPfam hit to PF01476, LysM domain, score 3.4e-14 216592014590 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 1.8e-12 216592014591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592014592 dimerization interface [polypeptide binding]; other site 216592014593 putative DNA binding site [nucleotide binding]; other site 216592014594 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216592014595 putative Zn2+ binding site [ion binding]; other site 216592014596 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 5.1e-26 216592014597 Predicted helix-turn-helix motif with score 1155.000, SD 3.12 at aa 39-60, sequence TSAGELTRITGLSASATSQHLA 216592014598 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 216592014599 active site residue [active] 216592014600 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 216592014601 PS00287 Cysteine proteases inhibitors signature. 216592014602 2 probable transmembrane helices predicted for EC042_2864 by TMHMM2.0 at aa 119-141 and 146-165 216592014603 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 216592014604 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 216592014605 HMMPfam hit to PF00816, H-NS histone family, score 4.8e-48 216592014606 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 216592014607 HMMPfam hit to PF06610, Protein of unknown function (DUF1144), score 2.2e-104 216592014608 3 probable transmembrane helices predicted for EC042_2866 by TMHMM2.0 at aa 15-34, 41-60 and 110-132 216592014609 hypothetical protein; Provisional; Region: PRK10556 216592014610 hypothetical protein; Provisional; Region: PRK10132 216592014611 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 1.1e-41 216592014612 1 probable transmembrane helix predicted for EC042_2868 by TMHMM2.0 at aa 87-106 216592014613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216592014614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592014615 DNA-binding site [nucleotide binding]; DNA binding site 216592014616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592014617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592014618 homodimer interface [polypeptide binding]; other site 216592014619 catalytic residue [active] 216592014620 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 2.3e-20 216592014621 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 27-48, sequence PSSRTWSQELGVSRSTVENAYA 216592014622 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216592014623 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216592014624 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase family, score 1.4e-23 216592014625 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 216592014626 catalytic residues [active] 216592014627 PS00190 Cytochrome c family heme-binding site signature. 216592014628 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 216592014629 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 216592014630 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 216592014631 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216592014632 active site 216592014633 dimer interface [polypeptide binding]; other site 216592014634 catalytic residues [active] 216592014635 effector binding site; other site 216592014636 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 216592014637 HMMPfam hit to PF00317, Ribonucleotide reductase, all-alpha d, score 2.7e-26 216592014638 HMMPfam hit to PF02867, Ribonucleotide reductase, barrel doma, score 7.7e-257 216592014639 PS00089 Ribonucleotide reductase large subunit signature. 216592014640 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 216592014641 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216592014642 dimer interface [polypeptide binding]; other site 216592014643 putative radical transfer pathway; other site 216592014644 diiron center [ion binding]; other site 216592014645 tyrosyl radical; other site 216592014646 HMMPfam hit to PF00268, Ribonucleotide reductase, small chain, score 2.4e-107 216592014647 PS00368 Ribonucleotide reductase small subunit signature. 216592014648 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 216592014649 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 216592014650 Walker A/P-loop; other site 216592014651 ATP binding site [chemical binding]; other site 216592014652 Q-loop/lid; other site 216592014653 ABC transporter signature motif; other site 216592014654 Walker B; other site 216592014655 D-loop; other site 216592014656 H-loop/switch region; other site 216592014657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 216592014658 HMMPfam hit to PF00005, ABC transporter, score 1.5e-71 216592014659 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014660 PS00211 ABC transporters family signature. 216592014661 HMMPfam hit to PF00571, CBS domain, score 8.2e-06 216592014662 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 216592014663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592014664 dimer interface [polypeptide binding]; other site 216592014665 conserved gate region; other site 216592014666 putative PBP binding loops; other site 216592014667 ABC-ATPase subunit interface; other site 216592014668 6 probable transmembrane helices predicted for EC042_2876 by TMHMM2.0 at aa 94-116, 120-142, 149-171, 197-219, 272-294 and 298-320 216592014669 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.5e-34 216592014670 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592014671 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 216592014672 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216592014673 Signal peptide predicted for EC042_2877 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592014674 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 1.8e-97 216592014675 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216592014676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592014677 Signal peptide predicted for EC042_2878 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.529 between residues 25 and 26 216592014678 10 probable transmembrane helices predicted for EC042_2878 by TMHMM2.0 at aa 7-29, 44-66, 78-100, 104-126, 133-155, 160-182, 217-239, 249-271, 284-306 and 362-384 216592014679 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.4e-46 216592014680 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014681 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 216592014682 5 probable transmembrane helices predicted for EC042_2879 by TMHMM2.0 at aa 22-44, 59-81, 139-161, 171-193 and 205-238 216592014683 HMMPfam hit to PF03591, AzlC protein, score 5.9e-75 216592014684 putative L-valine exporter; Provisional; Region: PRK10408 216592014685 3 probable transmembrane helices predicted for EC042_2880 by TMHMM2.0 at aa 5-24, 37-59 and 90-109 216592014686 transcriptional repressor MprA; Provisional; Region: PRK10870 216592014687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216592014688 HMMPfam hit to PF01047, MarR family, score 2.3e-38 216592014689 PS01117 Bacterial regulatory proteins, marR family signature. 216592014690 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 216592014691 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592014692 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592014693 Signal peptide predicted for EC042_2882 by SignalP 2.0 HMM (Signal peptide probability 0.604) with cleavage site probability 0.578 between residues 41 and 42 216592014694 1 probable transmembrane helix predicted for EC042_2882 by TMHMM2.0 at aa 27-49 216592014695 HMMPfam hit to PF00529, HlyD family secretion protein, score 6.9e-86 216592014696 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216592014697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592014698 putative substrate translocation pore; other site 216592014699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592014700 13 probable transmembrane helices predicted for EC042_2883 by TMHMM2.0 at aa 12-31, 54-76, 83-105, 109-131, 143-165, 170-192, 204-222, 237-254, 273-295, 305-327, 339-356, 371-393 and 483-501 216592014701 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-56 216592014702 S-ribosylhomocysteinase; Provisional; Region: PRK02260 216592014703 HMMPfam hit to PF02664, LuxS protein, score 1.2e-119 216592014704 glutamate--cysteine ligase; Provisional; Region: PRK02107 216592014705 HMMPfam hit to PF04262, Glutamate-cysteine ligase, score 2.8e-291 216592014706 Predicted membrane protein [Function unknown]; Region: COG1238 216592014707 4 probable transmembrane helices predicted for EC042_2886 by TMHMM2.0 at aa 7-29, 44-66, 86-108 and 113-135 216592014708 Signal peptide predicted for EC042_2886 by SignalP 2.0 HMM (Signal peptide probability 0.978) with cleavage site probability 0.591 between residues 18 and 19 216592014709 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 216592014710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592014711 motif II; other site 216592014712 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.2e-35 216592014713 1 probable transmembrane helix predicted for EC042_2888 by TMHMM2.0 at aa 20-42 216592014714 carbon storage regulator; Provisional; Region: PRK01712 216592014715 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 216592014716 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 216592014717 motif 1; other site 216592014718 active site 216592014719 motif 2; other site 216592014720 motif 3; other site 216592014721 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216592014722 DHHA1 domain; Region: DHHA1; pfam02272 216592014723 HMMPfam hit to PF02272, DHHA1 domain, score 2.3e-22 216592014724 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 216592014725 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592014726 recombination regulator RecX; Reviewed; Region: recX; PRK00117 216592014727 HMMPfam hit to PF02631, RecX family, score 6.3e-67 216592014728 recombinase A; Provisional; Region: recA; PRK09354 216592014729 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 216592014730 hexamer interface [polypeptide binding]; other site 216592014731 Walker A motif; other site 216592014732 ATP binding site [chemical binding]; other site 216592014733 Walker B motif; other site 216592014734 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 1.9e-242 216592014735 PS00321 recA signature. 216592014736 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014737 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014738 hypothetical protein; Validated; Region: PRK03661 216592014739 HMMPfam hit to PF02464, Competence-damaged protein, score 1.6e-99 216592014740 Transglycosylase SLT domain; Region: SLT_2; pfam13406 216592014741 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592014742 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592014743 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014744 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 216592014745 HMMPfam hit to PF03608, PTS system enzyme II sorbitol-specific facto, score 1.3e-143 216592014746 3 probable transmembrane helices predicted for EC042_2895 by TMHMM2.0 at aa 26-48, 68-90 and 139-161 216592014747 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 216592014748 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 216592014749 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 216592014750 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II N-t, score 2.3e-124 216592014751 PS00107 Protein kinases ATP-binding region signature. 216592014752 4 probable transmembrane helices predicted for EC042_2896 by TMHMM2.0 at aa 177-199, 214-236, 243-265 and 296-318 216592014753 HMMPfam hit to PF07663, Sorbitol phosphotransferase enzyme II C-t, score 2.2e-56 216592014754 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 216592014755 HMMPfam hit to PF03829, PTS system glucitol/sorbitol-specific IIA, score 3.1e-78 216592014756 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 216592014757 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 216592014758 putative NAD(P) binding site [chemical binding]; other site 216592014759 active site 216592014760 HMMPfam hit to PF00106, short chain dehydrogenase, score 5.2e-84 216592014761 PS00061 Short-chain dehydrogenases/reductases family signature. 216592014762 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 216592014763 Signal peptide predicted for EC042_2899 by SignalP 2.0 HMM (Signal peptide probability 0.804) with cleavage site probability 0.744 between residues 20 and 21 216592014764 HMMPfam hit to PF06923, Glucitol operon activator protein (GutM), score 2.8e-64 216592014765 1 probable transmembrane helix predicted for EC042_2899 by TMHMM2.0 at aa 2-24 216592014766 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 216592014767 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216592014768 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592014769 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 2.1e-120 216592014770 PS00894 Bacterial regulatory proteins, deoR family signature. 216592014771 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 216592014772 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 216592014773 putative active site [active] 216592014774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216592014775 HMMPfam hit to PF01380, SIS domain, score 4.4e-31 216592014776 HMMPfam hit to PF00571, CBS domain, score 1.4e-05 216592014777 HMMPfam hit to PF00571, CBS domain, score 2.2e-08 216592014778 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 216592014779 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592014780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592014781 Walker A motif; other site 216592014782 ATP binding site [chemical binding]; other site 216592014783 Walker B motif; other site 216592014784 arginine finger; other site 216592014785 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592014786 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2e-143 216592014787 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592014788 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592014789 HMMPfam hit to PF01590, GAF domain, score 4.6e-14 216592014790 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 216592014791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216592014792 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 216592014793 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 216592014794 iron binding site [ion binding]; other site 216592014795 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.6e-27 216592014796 HMMPfam hit to PF00258, Flavodoxin, score 3e-23 216592014797 HMMPfam hit to PF00301, Rubredoxin, score 6.8e-24 216592014798 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 216592014799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592014800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592014801 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 4.3e-65 216592014802 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 216592014803 Acylphosphatase; Region: Acylphosphatase; pfam00708 216592014804 HypF finger; Region: zf-HYPF; pfam07503 216592014805 HypF finger; Region: zf-HYPF; pfam07503 216592014806 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 216592014807 HMMPfam hit to PF00814, Glycoprotease family, score 1.4e-18 216592014808 HMMPfam hit to PF01300, yrdC domain, score 8.3e-79 216592014809 HMMPfam hit to PF07503, HypF finger, score 4e-18 216592014810 HMMPfam hit to PF07503, HypF finger, score 1.6e-16 216592014811 HMMPfam hit to PF00708, Acylphosphatase, score 1.4e-06 216592014812 PS00150 Acylphosphatase signature 1. 216592014813 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 216592014814 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 216592014815 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 6.8e-08 216592014816 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592014817 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.01 216592014818 Present in 0157, absent in Uropathogenic, ascBF operon (regulator, PTS protein and 6-phospho-beta-glucosidase 216592014819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216592014820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592014821 DNA binding site [nucleotide binding] 216592014822 domain linker motif; other site 216592014823 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 216592014824 dimerization interface (closed form) [polypeptide binding]; other site 216592014825 ligand binding site [chemical binding]; other site 216592014826 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.2e-12 216592014827 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.2e-11 216592014828 Predicted helix-turn-helix motif with score 1940.000, SD 5.79 at aa 16-37, sequence TTMLEVAKRAGVSKATVSRVLS 216592014829 PS00356 Bacterial regulatory proteins, lacI family signature. 216592014830 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 216592014831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592014832 active site turn [active] 216592014833 phosphorylation site [posttranslational modification] 216592014834 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 216592014835 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.6e-19 216592014836 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592014837 8 probable transmembrane helices predicted for EC042_2908 by TMHMM2.0 at aa 104-126, 146-168, 180-197, 212-234, 255-277, 282-304, 389-411 and 434-456 216592014838 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.1e-57 216592014839 Signal peptide predicted for EC042_2909 by SignalP 2.0 HMM (Signal peptide probability 0.612) with cleavage site probability 0.538 between residues 19 and 20 216592014840 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 216592014841 beta-galactosidase; Region: BGL; TIGR03356 216592014842 HMMPfam hit to PF00232, Glycosyl hydrolase family, score 8.5e-149 216592014843 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 216592014844 PS00572 Glycosyl hydrolases family 1 active site. 216592014845 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 216592014846 nickel binding site [ion binding]; other site 216592014847 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 3.6e-40 216592014848 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 216592014849 HMMPfam hit to PF07450, Formate hydrogenlyase maturation protein Hyc, score 6e-110 216592014850 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 216592014851 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1.1e-52 216592014852 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 216592014853 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 216592014854 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592014855 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.3e-08 216592014856 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592014857 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 5.7e-07 216592014858 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592014859 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 216592014860 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 216592014861 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 216592014862 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 5.6e-13 216592014863 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 216592014864 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 1.8e-26 216592014865 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 216592014866 NADH dehydrogenase; Region: NADHdh; cl00469 216592014867 HMMPfam hit to PF00146, NADH dehydrogenase, score 8.2e-108 216592014868 8 probable transmembrane helices predicted for EC042_2916 by TMHMM2.0 at aa 7-29, 69-91, 98-116, 131-153, 166-188, 218-240, 252-274 and 289-306 216592014869 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 216592014870 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 216592014871 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 216592014872 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216592014873 14 probable transmembrane helices predicted for EC042_2917 by TMHMM2.0 at aa 5-27, 47-69, 76-98, 113-134, 155-177, 197-219, 231-253, 257-279, 292-311, 326-348, 373-395, 415-437, 457-479 and 499-521 216592014874 HMMPfam hit to PF00361, NADH-Ubiquinone/plastoquinone (complex I), score 3e-29 216592014875 Signal peptide predicted for EC042_2917 by SignalP 2.0 HMM (Signal peptide probability 0.995) with cleavage site probability 0.606 between residues 48 and 49 216592014876 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 216592014877 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.1e-07 216592014878 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592014879 PS00190 Cytochrome c family heme-binding site signature. 216592014880 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 216592014881 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 216592014882 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 216592014883 HMMPfam hit to PF01155, Hydrogenase expression/synthesis hypA family, score 9.3e-60 216592014884 PS00213 Lipocalin signature. 216592014885 PS01249 Hydrogenases expression/synthesis hypA family signature. 216592014886 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 216592014887 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 5.7e-71 216592014888 hydrogenase assembly chaperone; Provisional; Region: PRK10409 216592014889 HMMPfam hit to PF01455, HupF/HypC family, score 1.7e-45 216592014890 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 216592014891 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 216592014892 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 216592014893 HMMPfam hit to PF01924, Hydrogenase formation hypA family, score 5.2e-270 216592014894 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 216592014895 dimerization interface [polypeptide binding]; other site 216592014896 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 216592014897 ATP binding site [chemical binding]; other site 216592014898 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 1.4e-40 216592014899 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 5.4e-37 216592014900 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 216592014901 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592014902 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592014903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592014904 Walker A motif; other site 216592014905 ATP binding site [chemical binding]; other site 216592014906 Walker B motif; other site 216592014907 arginine finger; other site 216592014908 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 216592014909 HMMPfam hit to PF01590, GAF domain, score 3.2e-18 216592014910 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.8e-148 216592014911 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592014912 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592014913 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 7.7e-10 216592014914 molybdenum-pterin binding domain; Region: Mop; TIGR00638 216592014915 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 216592014916 HMMPfam hit to PF03459, TOBE domain, score 2.4e-15 216592014917 HMMPfam hit to PF03459, TOBE domain, score 2.8e-11 216592014918 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 216592014919 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 216592014920 MutS domain I; Region: MutS_I; pfam01624 216592014921 MutS domain II; Region: MutS_II; pfam05188 216592014922 MutS domain III; Region: MutS_III; pfam05192 216592014923 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 216592014924 Walker A/P-loop; other site 216592014925 ATP binding site [chemical binding]; other site 216592014926 Q-loop/lid; other site 216592014927 ABC transporter signature motif; other site 216592014928 Walker B; other site 216592014929 D-loop; other site 216592014930 H-loop/switch region; other site 216592014931 HMMPfam hit to PF01624, MutS domain I, score 7.8e-74 216592014932 HMMPfam hit to PF05188, MutS domain II, score 7.6e-49 216592014933 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592014934 HMMPfam hit to PF05192, MutS domain III, score 7.4e-96 216592014935 HMMPfam hit to PF05190, MutS family domain IV, score 3.7e-41 216592014936 Predicted helix-turn-helix motif with score 1056.000, SD 2.78 at aa 479-500, sequence RGQSHLAPINYMRRQTLKNAER 216592014937 HMMPfam hit to PF00488, MutS domain V, score 4.9e-173 216592014938 PS00017 ATP/GTP-binding site motif A (P-loop). 216592014939 PS00486 DNA mismatch repair proteins mutS family signature. 216592014940 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216592014941 Sel1-like repeats; Region: SEL1; smart00671 216592014942 Sel1-like repeats; Region: SEL1; smart00671 216592014943 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592014944 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 216592014945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216592014946 active site 216592014947 metal binding site [ion binding]; metal-binding site 216592014948 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.2e-16 216592014949 Present in 0157, divergent in Uropathogenic. Three subunits of hydroxyarylic acid decarboxylases/phenol carboxylase and their regulator 216592014950 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 216592014951 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 216592014952 HMMPfam hit to PF01977, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 8.4e-158 216592014953 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 216592014954 Flavoprotein; Region: Flavoprotein; pfam02441 216592014955 HMMPfam hit to PF02441, Flavoprotein, score 3e-46 216592014956 MarR family; Region: MarR_2; cl17246 216592014957 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216592014958 HMMPfam hit to PF01047, MarR family, score 4.1e-23 216592014959 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 216592014960 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216592014961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592014962 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216592014963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592014964 DNA binding residues [nucleotide binding] 216592014965 HMMPfam hit to PF04545, Sigma-70, region, score 1.4e-18 216592014966 PS00716 Sigma-70 factors family signature 2. 216592014967 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 286-307, sequence ATLEDVGREIGLTRERVRQIQV 216592014968 HMMPfam hit to PF04539, Sigma-70 region, score 1.3e-24 216592014969 HMMPfam hit to PF04542, Sigma-70 region, score 3.7e-27 216592014970 PS00715 Sigma-70 factors family signature 1. 216592014971 HMMPfam hit to PF00140, Sigma-70 factor, region, score 2.8e-13 216592014972 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216592014973 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592014974 Peptidase family M23; Region: Peptidase_M23; pfam01551 216592014975 HMMPfam hit to PF01551, Peptidase family M23, score 4.5e-46 216592014976 HMMPfam hit to PF01476, LysM domain, score 3.1e-13 216592014977 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592014978 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 216592014979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592014980 S-adenosylmethionine binding site [chemical binding]; other site 216592014981 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyl, score 4.3e-130 216592014982 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 216592014983 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592014984 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 216592014985 HMMPfam hit to PF01975, Survival protein SurE, score 9.3e-112 216592014986 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 216592014987 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 216592014988 Permutation of conserved domain; other site 216592014989 active site 216592014990 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 1.6e-163 216592014991 PS01268 Uncharacterized protein family UPF0024 signature. 216592014992 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 216592014993 homotrimer interaction site [polypeptide binding]; other site 216592014994 zinc binding site [ion binding]; other site 216592014995 CDP-binding sites; other site 216592014996 HMMPfam hit to PF02542, YgbB family, score 3.2e-103 216592014997 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 216592014998 substrate binding site; other site 216592014999 dimer interface; other site 216592015000 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 2.3e-150 216592015001 PS01295 Uncharacterized protein family UPF0007 signature. 216592015002 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 216592015003 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 216592015004 HMMPfam hit to PF04977, Septum formation initiator, score 1e-40 216592015005 1 probable transmembrane helix predicted for EC042_2942 by TMHMM2.0 at aa 4-21 216592015006 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 216592015007 3 probable transmembrane helices predicted for EC042_2943 by TMHMM2.0 at aa 21-43, 53-75 and 87-106 216592015008 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 216592015009 ligand-binding site [chemical binding]; other site 216592015010 HMMPfam hit to PF01583, Adenylylsulphate kinase, score 1.6e-115 216592015011 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015012 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 216592015013 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 216592015014 CysD dimerization site [polypeptide binding]; other site 216592015015 G1 box; other site 216592015016 putative GEF interaction site [polypeptide binding]; other site 216592015017 GTP/Mg2+ binding site [chemical binding]; other site 216592015018 Switch I region; other site 216592015019 G2 box; other site 216592015020 G3 box; other site 216592015021 Switch II region; other site 216592015022 G4 box; other site 216592015023 G5 box; other site 216592015024 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 216592015025 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 216592015026 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.9e-09 216592015027 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.7e-71 216592015028 PS00301 GTP-binding elongation factors signature. 216592015029 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015030 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 216592015031 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592015032 Active Sites [active] 216592015033 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 1.8e-97 216592015034 PS00215 Mitochondrial energy transfer proteins signature. 216592015035 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 216592015036 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 216592015037 metal binding site [ion binding]; metal-binding site 216592015038 HMMPfam hit to PF04389, Peptidase family M28, score 1.6e-42 216592015039 CRISPR-associated genes. Present in 0157, absent in Uropathogenic, repeat array region is a different size to those found in 0157 216592015040 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 216592015041 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 216592015042 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 216592015043 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 216592015044 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 216592015045 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 216592015046 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 216592015047 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 216592015048 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015049 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 216592015050 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 216592015051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216592015052 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.018 216592015053 Hok/gef family; Region: HOK_GEF; pfam01848 216592015054 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 216592015055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592015056 Active Sites [active] 216592015057 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 4.2e-87 216592015058 sulfite reductase subunit beta; Provisional; Region: PRK13504 216592015059 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216592015060 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216592015061 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 216592015062 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 2.3e-18 216592015063 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 1.2e-60 216592015064 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 1.8e-19 216592015065 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 216592015066 Flavodoxin; Region: Flavodoxin_1; pfam00258 216592015067 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 216592015068 FAD binding pocket [chemical binding]; other site 216592015069 FAD binding motif [chemical binding]; other site 216592015070 catalytic residues [active] 216592015071 NAD binding pocket [chemical binding]; other site 216592015072 phosphate binding motif [ion binding]; other site 216592015073 beta-alpha-beta structure motif; other site 216592015074 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 7.2e-44 216592015075 HMMPfam hit to PF00667, FAD binding domain, score 9.4e-81 216592015076 HMMPfam hit to PF00258, Flavodoxin, score 6.9e-42 216592015077 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 216592015078 homohexamer interface [polypeptide binding]; other site 216592015079 putative substrate stabilizing pore; other site 216592015080 pterin binding site; other site 216592015081 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase, score 6.3e-86 216592015082 putative oxidoreductase FixC; Provisional; Region: PRK10157 216592015083 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.1e-16 216592015084 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015085 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 216592015086 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 216592015087 HMMPfam hit to PF04309, Glycerol-3-phosphate responsive antiterm, score 8.7e-109 216592015088 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216592015089 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 216592015090 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216592015091 HMMPfam hit to PF00766, Electron transfer flavoprotein alpha subuni, score 1.4e-08 216592015092 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216592015093 Ligand binding site [chemical binding]; other site 216592015094 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216592015095 HMMPfam hit to PF01012, Electron transfer flavoprotein beta subunit, score 5.7e-99 216592015096 benzoate transport; Region: 2A0115; TIGR00895 216592015097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015098 putative substrate translocation pore; other site 216592015099 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.6e-44 216592015100 12 probable transmembrane helices predicted for EC042_2965 by TMHMM2.0 at aa 48-70, 80-102, 111-130, 135-157, 169-188, 198-220, 276-298, 308-330, 337-356, 361-383, 395-417 and 422-444 216592015101 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.8e-38 216592015102 PS00217 Sugar transport proteins signature 2. 216592015103 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216592015104 FAD binding domain; Region: FAD_binding_4; pfam01565 216592015105 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 1.2e-07 216592015106 HMMPfam hit to PF01565, FAD binding domain, score 5.3e-52 216592015107 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 216592015108 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 216592015109 NADP binding site [chemical binding]; other site 216592015110 homodimer interface [polypeptide binding]; other site 216592015111 active site 216592015112 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.3e-72 216592015113 PS00061 Short-chain dehydrogenases/reductases family signature. 216592015114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592015115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015116 12 probable transmembrane helices predicted for EC042_2968 by TMHMM2.0 at aa 13-32, 47-69, 78-95, 99-121, 142-159, 174-193, 220-242, 257-279, 292-309, 319-341, 353-375 and 390-409 216592015117 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-18 216592015118 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216592015119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216592015120 nucleotide binding site [chemical binding]; other site 216592015121 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.2e-08 216592015122 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 2.1e-11 216592015123 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 216592015124 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 216592015125 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 216592015126 HMMPfam hit to PF04011, LemA family, score 3.4e-70 216592015127 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 216592015128 Repair protein; Region: Repair_PSII; pfam04536 216592015129 4 probable transmembrane helices predicted for EC042_2973 by TMHMM2.0 at aa 13-32, 181-198, 205-227 and 231-253 216592015130 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 1.9e-53 216592015131 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 216592015132 Repair protein; Region: Repair_PSII; pfam04536 216592015133 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 3.4e-36 216592015134 5 probable transmembrane helices predicted for EC042_2975 by TMHMM2.0 at aa 178-195, 200-217, 221-243, 278-300 and 310-332 216592015135 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 216592015136 Repair protein; Region: Repair_PSII; pfam04536 216592015137 HMMPfam hit to PF04536, Domain of unknown function (DUF477), score 1.5e-57 216592015138 3 probable transmembrane helices predicted for EC042_2977 by TMHMM2.0 at aa 173-192, 197-214 and 224-246 216592015139 enolase; Provisional; Region: eno; PRK00077 216592015140 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216592015141 dimer interface [polypeptide binding]; other site 216592015142 metal binding site [ion binding]; metal-binding site 216592015143 substrate binding pocket [chemical binding]; other site 216592015144 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 1.2e-190 216592015145 PS00164 Enolase signature. 216592015146 HMMPfam hit to PF03952, Enolase, N-terminal domain, score 3.3e-71 216592015147 CTP synthetase; Validated; Region: pyrG; PRK05380 216592015148 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 216592015149 Catalytic site [active] 216592015150 active site 216592015151 UTP binding site [chemical binding]; other site 216592015152 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 216592015153 active site 216592015154 putative oxyanion hole; other site 216592015155 catalytic triad [active] 216592015156 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.3e-77 216592015157 PS00442 Glutamine amidotransferases class-I active site. 216592015158 HMMPfam hit to PF06418, CTP synthase N-terminus, score 1.2e-214 216592015159 1 probable transmembrane helix predicted for EC042_2979 by TMHMM2.0 at aa 7-29 216592015160 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 216592015161 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 216592015162 homodimer interface [polypeptide binding]; other site 216592015163 metal binding site [ion binding]; metal-binding site 216592015164 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 216592015165 homodimer interface [polypeptide binding]; other site 216592015166 active site 216592015167 putative chemical substrate binding site [chemical binding]; other site 216592015168 metal binding site [ion binding]; metal-binding site 216592015169 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 3.3e-43 216592015170 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 216592015171 HD domain; Region: HD_4; pfam13328 216592015172 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216592015173 synthetase active site [active] 216592015174 NTP binding site [chemical binding]; other site 216592015175 metal binding site [ion binding]; metal-binding site 216592015176 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 216592015177 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216592015178 HMMPfam hit to PF01842, ACT domain, score 1.4e-14 216592015179 HMMPfam hit to PF02824, TGS domain, score 5.5e-32 216592015180 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 1.7e-48 216592015181 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 216592015182 TRAM domain; Region: TRAM; pfam01938 216592015183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592015184 S-adenosylmethionine binding site [chemical binding]; other site 216592015185 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 1.7e-10 216592015186 PS01231 RNA methyltransferase trmA family signature 2. 216592015187 PS01230 RNA methyltransferase trmA family signature 1. 216592015188 HMMPfam hit to PF01938, TRAM domain, score 8.4e-17 216592015189 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 216592015190 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 216592015191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592015192 dimerization interface [polypeptide binding]; other site 216592015193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592015194 dimer interface [polypeptide binding]; other site 216592015195 phosphorylation site [posttranslational modification] 216592015196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592015197 ATP binding site [chemical binding]; other site 216592015198 Mg2+ binding site [ion binding]; other site 216592015199 G-X-G motif; other site 216592015200 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 216592015201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592015202 active site 216592015203 phosphorylation site [posttranslational modification] 216592015204 intermolecular recognition site; other site 216592015205 dimerization interface [polypeptide binding]; other site 216592015206 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216592015207 putative binding surface; other site 216592015208 active site 216592015209 2 probable transmembrane helices predicted for EC042_2983 by TMHMM2.0 at aa 10-32 and 177-199 216592015210 HMMPfam hit to PF00672, HAMP domain, score 1.7e-13 216592015211 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.6e-27 216592015212 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.1e-42 216592015213 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-43 216592015214 HMMPfam hit to PF01627, Hpt domain, score 4.1e-17 216592015215 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 216592015216 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 216592015217 active site 216592015218 tetramer interface [polypeptide binding]; other site 216592015219 PS00294 Prenyl group binding site (CAAX box). 216592015220 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 5.2e-06 216592015221 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 216592015222 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 216592015223 active site 216592015224 tetramer interface [polypeptide binding]; other site 216592015225 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 4.6e-06 216592015226 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 0.0004 216592015227 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216592015228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015229 D-galactonate transporter; Region: 2A0114; TIGR00893 216592015230 putative substrate translocation pore; other site 216592015231 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2e-05 216592015232 12 probable transmembrane helices predicted for EC042_2987 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 152-174, 179-201, 256-278, 293-315, 328-348, 352-374, 387-409 and 414-436 216592015233 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-62 216592015234 flavodoxin; Provisional; Region: PRK08105 216592015235 HMMPfam hit to PF00258, Flavodoxin, score 6.3e-35 216592015236 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216592015237 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 216592015238 probable active site [active] 216592015239 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4.7e-54 216592015240 PS01129 Rlu family of pseudouridine synthase signature. 216592015241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 216592015242 HMMPfam hit to PF04287, Domain of unknown function, DUF446, score 2.7e-67 216592015243 SecY interacting protein Syd; Provisional; Region: PRK04968 216592015244 HMMPfam hit to PF07348, Syd protein, score 1.4e-130 216592015245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 216592015246 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 216592015247 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 216592015248 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015249 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 3.1e-07 216592015250 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 216592015251 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 216592015252 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 1.6e-57 216592015253 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216592015254 serine transporter; Region: stp; TIGR00814 216592015255 11 probable transmembrane helices predicted for EC042_2994 by TMHMM2.0 at aa 24-41, 45-67, 103-125, 140-157, 164-186, 206-228, 249-271, 300-322, 351-373, 377-394 and 406-428 216592015256 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216592015257 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216592015258 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216592015259 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 1.8e-108 216592015260 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.4e-203 216592015261 flap endonuclease-like protein; Provisional; Region: PRK09482 216592015262 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216592015263 active site 216592015264 metal binding site 1 [ion binding]; metal-binding site 216592015265 putative 5' ssDNA interaction site; other site 216592015266 metal binding site 3; metal-binding site 216592015267 metal binding site 2 [ion binding]; metal-binding site 216592015268 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216592015269 putative DNA binding site [nucleotide binding]; other site 216592015270 putative metal binding site [ion binding]; other site 216592015271 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 1.8e-13 216592015272 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 9.4e-24 216592015273 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 216592015274 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 216592015275 dimer interface [polypeptide binding]; other site 216592015276 active site 216592015277 metal binding site [ion binding]; metal-binding site 216592015278 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 4e-206 216592015279 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592015280 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592015281 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 216592015282 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 216592015283 intersubunit interface [polypeptide binding]; other site 216592015284 active site 216592015285 Zn2+ binding site [ion binding]; other site 216592015286 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 8.7e-78 216592015287 1 probable transmembrane helix predicted for EC042_2999 by TMHMM2.0 at aa 23-42 216592015288 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 216592015289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015290 putative substrate translocation pore; other site 216592015291 12 probable transmembrane helices predicted for EC042_3000 by TMHMM2.0 at aa 21-41, 61-83, 88-110, 120-142, 155-177, 212-234, 260-282, 292-314, 327-346, 351-373, 382-404 and 414-431 216592015292 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.4e-19 216592015293 L-fucose isomerase; Provisional; Region: fucI; PRK10991 216592015294 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 216592015295 hexamer (dimer of trimers) interface [polypeptide binding]; other site 216592015296 trimer interface [polypeptide binding]; other site 216592015297 substrate binding site [chemical binding]; other site 216592015298 Mn binding site [ion binding]; other site 216592015299 HMMPfam hit to PF02952, L-fucose isomerase, C-terminal domain, score 1.3e-125 216592015300 L-fuculokinase; Provisional; Region: PRK10331 216592015301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216592015302 nucleotide binding site [chemical binding]; other site 216592015303 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 2.9e-127 216592015304 PS00933 FGGY family of carbohydrate kinases signature 1. 216592015305 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 4.7e-97 216592015306 PS00445 FGGY family of carbohydrate kinases signature 2. 216592015307 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 216592015308 HMMPfam hit to PF05025, RbsD / FucU transport protein family, score 4.9e-64 216592015309 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 216592015310 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216592015311 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592015312 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 6.1e-117 216592015313 PS00894 Bacterial regulatory proteins, deoR family signature. 216592015314 Predicted helix-turn-helix motif with score 1859.000, SD 5.52 at aa 22-43, sequence LTTEALSEQLKVSKETIRRDLN 216592015315 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 216592015316 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 216592015317 hypothetical protein; Provisional; Region: PRK10873 216592015318 3 probable transmembrane helices predicted for EC042_3006 by TMHMM2.0 at aa 15-29, 36-58 and 68-90 216592015319 HMMPfam hit to PF04241, Protein of unknown function (DUF423), score 3.2e-30 216592015320 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216592015321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592015322 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216592015323 dimerization interface [polypeptide binding]; other site 216592015324 substrate binding pocket [chemical binding]; other site 216592015325 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.5e-46 216592015326 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.4e-22 216592015327 PS00044 Bacterial regulatory proteins, lysR family signature. 216592015328 Predicted helix-turn-helix motif with score 1791.000, SD 5.29 at aa 21-42, sequence LSFTRAAEELFVTQAAVSHQIK 216592015329 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 216592015330 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 8.3e-48 216592015331 1 probable transmembrane helix predicted for EC042_3008 by TMHMM2.0 at aa 5-27 216592015332 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015333 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216592015334 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216592015335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592015336 catalytic residue [active] 216592015337 HMMPfam hit to PF00266, Aminotransferase class-V, score 2.6e-09 216592015338 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216592015339 CsdA-binding activator; Provisional; Region: PRK15019 216592015340 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 8.9e-73 216592015341 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 216592015342 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 216592015343 putative ATP binding site [chemical binding]; other site 216592015344 putative substrate interface [chemical binding]; other site 216592015345 1 probable transmembrane helix predicted for EC042_3011 by TMHMM2.0 at aa 235-257 216592015346 HMMPfam hit to PF00899, ThiF family, score 1.6e-55 216592015347 murein transglycosylase A; Provisional; Region: mltA; PRK11162 216592015348 MltA specific insert domain; Region: MltA; pfam03562 216592015349 3D domain; Region: 3D; pfam06725 216592015350 HMMPfam hit to PF06725, 3D domain, score 3.7e-36 216592015351 HMMPfam hit to PF03562, MltA N-terminal domain, score 1.6e-103 216592015352 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015353 AMIN domain; Region: AMIN; pfam11741 216592015354 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216592015355 active site 216592015356 metal binding site [ion binding]; metal-binding site 216592015357 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 5.9e-74 216592015358 N-acetylglutamate synthase; Validated; Region: PRK05279 216592015359 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 216592015360 putative feedback inhibition sensing region; other site 216592015361 putative nucleotide binding site [chemical binding]; other site 216592015362 putative substrate binding site [chemical binding]; other site 216592015363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592015364 Coenzyme A binding pocket [chemical binding]; other site 216592015365 HMMPfam hit to PF00696, Amino acid kinase family, score 4.8e-40 216592015366 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.7e-10 216592015367 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 216592015368 AAA domain; Region: AAA_30; pfam13604 216592015369 Family description; Region: UvrD_C_2; pfam13538 216592015370 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015371 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 216592015372 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.1e-179 216592015373 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015374 protease3; Provisional; Region: PRK15101 216592015375 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216592015376 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216592015377 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216592015378 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 2.7e-19 216592015379 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.6e-30 216592015380 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 2.4e-56 216592015381 PS00143 Insulinase family, zinc-binding region signature. 216592015382 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 216592015383 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 216592015384 HMMPfam hit to PF04257, Exodeoxyribonuclease V, gamma subunit, score 0 216592015385 hypothetical protein; Provisional; Region: PRK10332 216592015386 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 216592015387 1 probable transmembrane helix predicted for EC042_3019 by TMHMM2.0 at aa 15-37 216592015388 PS00409 Prokaryotic N-terminal methylation site. 216592015389 hypothetical protein; Provisional; Region: PRK11521 216592015390 1 probable transmembrane helix predicted for EC042_3020 by TMHMM2.0 at aa 7-29 216592015391 hypothetical protein; Provisional; Region: PRK10557 216592015392 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 216592015393 1 probable transmembrane helix predicted for EC042_3021 by TMHMM2.0 at aa 86-108 216592015394 hypothetical protein; Provisional; Region: PRK10506 216592015395 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 216592015396 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015397 thymidylate synthase; Reviewed; Region: thyA; PRK01827 216592015398 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216592015399 dimerization interface [polypeptide binding]; other site 216592015400 active site 216592015401 HMMPfam hit to PF00303, Thymidylate synthase, score 5.7e-192 216592015402 PS00091 Thymidylate synthase active site. 216592015403 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 216592015404 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 5e-148 216592015405 5 probable transmembrane helices predicted for EC042_3025 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282 216592015406 PS01311 Prolipoprotein diacylglyceryl transferase signature. 216592015407 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 216592015408 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 216592015409 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216592015410 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592015411 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216592015412 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.3e-167 216592015413 PS00742 PEP-utilizing enzymes signature 2. 216592015414 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 4.9e-22 216592015415 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216592015416 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 4.4e-43 216592015417 HMMPfam hit to PF01590, GAF domain, score 7.1e-27 216592015418 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 216592015419 putative active site [active] 216592015420 Ap4A binding site [chemical binding]; other site 216592015421 nudix motif; other site 216592015422 putative metal binding site [ion binding]; other site 216592015423 HMMPfam hit to PF00293, NUDIX domain, score 1.4e-29 216592015424 PS00893 mutT domain signature. 216592015425 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 216592015426 putative DNA-binding cleft [nucleotide binding]; other site 216592015427 putative DNA clevage site; other site 216592015428 molecular lever; other site 216592015429 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 5.3e-62 216592015430 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 216592015431 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 6.3e-104 216592015432 7 probable transmembrane helices predicted for EC042_3030 by TMHMM2.0 at aa 15-37, 50-69, 79-101, 122-139, 154-176, 183-202 and 212-230 216592015433 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 216592015434 HMMPfam hit to PF06004, Bacterial protein of unknown function (DUF90, score 1.6e-49 216592015435 1 probable transmembrane helix predicted for EC042_3031 by TMHMM2.0 at aa 4-26 216592015436 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592015438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592015439 active site 216592015440 catalytic tetrad [active] 216592015441 HMMPfam hit to PF00248, Aldo/keto reductase family, score 5.4e-48 216592015442 lysophospholipid transporter LplT; Provisional; Region: PRK11195 216592015443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015444 10 probable transmembrane helices predicted for EC042_3033 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 162-184, 220-242, 257-279, 286-303, 308-330, 343-365 and 370-392 216592015445 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.3e-07 216592015446 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 216592015447 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216592015448 putative acyl-acceptor binding pocket; other site 216592015449 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 216592015450 acyl-activating enzyme (AAE) consensus motif; other site 216592015451 putative AMP binding site [chemical binding]; other site 216592015452 HMMPfam hit to PF00501, AMP-binding enzyme, score 4.7e-77 216592015453 PS00455 Putative AMP-binding domain signature. 216592015454 HMMPfam hit to PF01553, Acyltransferase, score 6.1e-34 216592015455 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 216592015456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592015457 DNA binding site [nucleotide binding] 216592015458 domain linker motif; other site 216592015459 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 216592015460 dimerization interface (closed form) [polypeptide binding]; other site 216592015461 ligand binding site [chemical binding]; other site 216592015462 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.7e-14 216592015463 Predicted helix-turn-helix motif with score 2178.000, SD 6.60 at aa 2-23, sequence ATIKDVARLAGVSVATVSRVIN 216592015464 PS00356 Bacterial regulatory proteins, lacI family signature. 216592015465 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.5e-14 216592015466 diaminopimelate decarboxylase; Provisional; Region: PRK11165 216592015467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 216592015468 active site 216592015469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592015470 substrate binding site [chemical binding]; other site 216592015471 catalytic residues [active] 216592015472 dimer interface [polypeptide binding]; other site 216592015473 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 2.6e-56 216592015474 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 2.3e-106 216592015475 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 216592015476 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 216592015477 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 216592015478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592015479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592015480 dimerization interface [polypeptide binding]; other site 216592015481 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-11 216592015482 Predicted helix-turn-helix motif with score 2011.000, SD 6.04 at aa 4-25, sequence GSLTEAAHLLHTSQPTVSRELA 216592015483 PS00044 Bacterial regulatory proteins, lysR family signature. 216592015484 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.5e-49 216592015485 putative racemase; Provisional; Region: PRK10200 216592015486 aspartate racemase; Region: asp_race; TIGR00035 216592015487 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 3.2e-66 216592015488 PS00924 Aspartate and glutamate racemases signature 2. 216592015489 PS00923 Aspartate and glutamate racemases signature 1. 216592015490 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 216592015491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015492 putative substrate translocation pore; other site 216592015493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592015494 HMMPfam hit to PF00083, Sugar (and other) transporter, score 6.8e-173 216592015495 12 probable transmembrane helices predicted for EC042_3039 by TMHMM2.0 at aa 25-47, 62-84, 91-110, 115-137, 150-167, 177-199, 259-281, 296-318, 325-347, 362-384, 405-424 and 428-447 216592015496 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.3e-38 216592015497 PS00216 Sugar transport proteins signature 1. 216592015498 PS00217 Sugar transport proteins signature 2. 216592015499 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 216592015500 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 216592015501 NADP binding site [chemical binding]; other site 216592015502 homodimer interface [polypeptide binding]; other site 216592015503 active site 216592015504 HMMPfam hit to PF00106, short chain dehydrogenase, score 6.6e-86 216592015505 PS00061 Short-chain dehydrogenases/reductases family signature. 216592015506 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 216592015507 HMMPfam hit to PF04962, 5-keto 4-deoxyuronate isomerase, score 1.4e-228 216592015508 putative acyltransferase; Provisional; Region: PRK05790 216592015509 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216592015510 dimer interface [polypeptide binding]; other site 216592015511 active site 216592015512 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 4.9e-78 216592015513 PS00099 Thiolases active site. 216592015514 PS00737 Thiolases signature 2. 216592015515 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 1e-158 216592015516 PS00098 Thiolases acyl-enzyme intermediate signature. 216592015517 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216592015518 serine transporter; Region: stp; TIGR00814 216592015519 10 probable transmembrane helices predicted for EC042_3043 by TMHMM2.0 at aa 20-42, 86-108, 123-145, 152-174, 194-216, 236-258, 287-309, 334-356, 360-382 and 389-408 216592015520 Type III secretion system. Present in 0157, absent in Uropathogenic, APEC01 and EPEC. part of this region is in K12 (not TTSS) 216592015521 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 216592015522 DNA binding residues [nucleotide binding] 216592015523 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 216592015524 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 4.2e-18 216592015525 1 probable transmembrane helix predicted for EC042_3045 by TMHMM2.0 at aa 155-174 216592015526 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 216592015527 1 probable transmembrane helix predicted for EC042_3046 by TMHMM2.0 at aa 7-26 216592015528 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 216592015529 Tetratricopeptide repeat; Region: TPR_3; pfam07720 216592015530 Tetratricopeptide repeat; Region: TPR_3; pfam07720 216592015531 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 1.1e-11 216592015532 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 4.2e-11 216592015533 transcriptional regulator; Provisional; Region: PRK11906 216592015534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592015535 DNA binding site [nucleotide binding] 216592015536 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 1.1e-18 216592015537 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 5.6e-05 216592015538 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216592015539 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592015540 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592015541 catalytic residue [active] 216592015542 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 3.4e-41 216592015543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592015544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592015545 DNA binding residues [nucleotide binding] 216592015546 dimerization interface [polypeptide binding]; other site 216592015547 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1.9e-23 216592015548 PS00622 Bacterial regulatory proteins, luxR family signature. 216592015549 HMMPfam hit to PF00072, Response regulator receiver domain, score 0.00023 216592015550 invasion protein OrgB; Provisional; Region: PRK15322 216592015551 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 216592015552 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 216592015553 1 probable transmembrane helix predicted for EC042_3056 by TMHMM2.0 at aa 189-208 216592015554 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 1e-40 216592015555 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 216592015556 Type III secretion needle MxiH like; Region: MxiH; cl09641 216592015557 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 216592015558 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 216592015559 1 probable transmembrane helix predicted for EC042_3059 by TMHMM2.0 at aa 148-170 216592015560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592015561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592015562 DNA binding residues [nucleotide binding] 216592015563 dimerization interface [polypeptide binding]; other site 216592015564 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 2.3e-06 216592015565 Predicted helix-turn-helix motif with score 1131.000, SD 3.04 at aa 110-131, sequence YSLKQIAIIKGIDYKTVSYHKI 216592015566 type III secretion system protein SpaS; Validated; Region: PRK08156 216592015567 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 9.8e-129 216592015568 4 probable transmembrane helices predicted for EC042_3061 by TMHMM2.0 at aa 28-50, 75-97, 134-153 and 177-199 216592015569 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 216592015570 HMMPfam hit to PF01311, Bacterial export proteins, family, score 3.5e-65 216592015571 5 probable transmembrane helices predicted for EC042_3062 by TMHMM2.0 at aa 12-34, 78-100, 128-150, 180-202 and 209-231 216592015572 type III secretion system protein SpaQ; Provisional; Region: PRK15333 216592015573 HMMPfam hit to PF01313, Bacterial export proteins, family, score 1.5e-31 216592015574 2 probable transmembrane helices predicted for EC042_3063 by TMHMM2.0 at aa 12-34 and 49-68 216592015575 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 216592015576 HMMPfam hit to PF00813, FliP family, score 2.9e-103 216592015577 4 probable transmembrane helices predicted for EC042_3064 by TMHMM2.0 at aa 15-37, 50-67, 154-176 and 183-205 216592015578 PS01061 Flagella transport protein fliP family signature 2. 216592015579 type III secretion system protein SpaO; Validated; Region: PRK08158 216592015580 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 216592015581 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 1.3e-11 216592015582 potential frameshift: common BLAST hit: gi|218706364|ref|YP_002413883.1| type III secretion protein 216592015583 Surface presentation of antigens protein; Region: SPAN; pfam02510 216592015584 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 216592015585 ATP synthase SpaL; Validated; Region: PRK08149 216592015586 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216592015587 Walker A motif; other site 216592015588 ATP binding site [chemical binding]; other site 216592015589 Walker B motif; other site 216592015590 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 5.2e-104 216592015591 PS00152 ATP synthase alpha and beta subunits signature. 216592015592 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015593 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 216592015594 type III secretion system protein InvA; Provisional; Region: PRK15337 216592015595 HMMPfam hit to PF00771, FHIPEP family, score 0 216592015596 8 probable transmembrane helices predicted for EC042_3070 by TMHMM2.0 at aa 13-30, 35-57, 69-91, 106-128, 197-219, 239-261, 274-293 and 297-315 216592015597 PS00994 Bacterial export FHIPEP family signature. 216592015598 type III secretion system regulator InvE; Provisional; Region: PRK15338 216592015599 HrpJ-like domain; Region: HrpJ; pfam07201 216592015600 HMMPfam hit to PF02523, InvE invasion protein, score 7.1e-69 216592015601 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 216592015602 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216592015603 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 216592015604 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 8.6e-57 216592015605 PS00875 Bacterial type II secretion system protein D signature. 216592015606 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015607 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1.6e-10 216592015608 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 1.7e-06 216592015609 1 probable transmembrane helix predicted for EC042_3072 by TMHMM2.0 at aa 7-29 216592015610 transcriptional regulator InvF; Provisional; Region: PRK15340 216592015611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592015612 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.2e-06 216592015613 PS00041 Bacterial regulatory proteins, araC family signature. 216592015614 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.46 216592015615 Predicted helix-turn-helix motif with score 1534.000, SD 4.41 at aa 164-185, sequence TSLYDLGELYGVSYSHFRRLCS 216592015616 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 216592015617 2 probable transmembrane helices predicted for EC042_3074 by TMHMM2.0 at aa 20-42 and 52-74 216592015618 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 216592015619 1 probable transmembrane helix predicted for EC042_3075 by TMHMM2.0 at aa 20-39 216592015620 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015621 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216592015622 Peptidase family M23; Region: Peptidase_M23; pfam01551 216592015623 HMMPfam hit to PF01551, Peptidase family M23, score 5e-45 216592015624 HMMPfam hit to PF01476, LysM domain, score 2.5e-19 216592015625 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592015626 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 216592015627 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 216592015628 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216592015629 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydroge, score 2.2e-54 216592015630 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydroge, score 1.1e-244 216592015631 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 216592015632 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 216592015633 HMMPfam hit to PF00941, FAD binding domain in molybdopterin deh, score 3.6e-77 216592015634 HMMPfam hit to PF03450, CO dehydrogenase flavoprotein C-termina, score 2.7e-45 216592015635 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 216592015636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216592015637 catalytic loop [active] 216592015638 iron binding site [ion binding]; other site 216592015639 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216592015640 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 6.7e-05 216592015641 HMMPfam hit to PF01799, [2Fe-2S] binding domain, score 5.5e-41 216592015642 GAF domain; Region: GAF; cl17456 216592015643 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 216592015644 PAS domain; Region: PAS; smart00091 216592015645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592015646 Walker A motif; other site 216592015647 ATP binding site [chemical binding]; other site 216592015648 Walker B motif; other site 216592015649 arginine finger; other site 216592015650 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592015651 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 6.5e-16 216592015652 Predicted helix-turn-helix motif with score 1819.000, SD 5.38 at aa 564-585, sequence NSKKQVADELGIGIATLYRKIK 216592015653 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592015654 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.9e-148 216592015655 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015656 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592015657 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 216592015658 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216592015659 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216592015660 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 6.9e-11 216592015661 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 1.3e-06 216592015662 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 216592015663 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 216592015664 catalytic residue [active] 216592015665 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 3.5e-10 216592015666 peptidase; Reviewed; Region: PRK13004 216592015667 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 216592015668 putative metal binding site [ion binding]; other site 216592015669 putative dimer interface [polypeptide binding]; other site 216592015670 PS00148 Arginase family signature 2. 216592015671 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216592015672 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2.4e-17 216592015673 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1.9e-18 216592015674 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216592015675 D-hydantoinase; Region: D-hydantoinase; TIGR02033 216592015676 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 216592015677 tetramer interface [polypeptide binding]; other site 216592015678 active site 216592015679 HMMPfam hit to PF01979, Amidohydrolase family, score 2.3e-05 216592015680 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 216592015681 carbamate kinase; Reviewed; Region: PRK12686 216592015682 putative substrate binding site [chemical binding]; other site 216592015683 homodimer interface [polypeptide binding]; other site 216592015684 nucleotide binding site [chemical binding]; other site 216592015685 nucleotide binding site [chemical binding]; other site 216592015686 HMMPfam hit to PF00696, Amino acid kinase family, score 1e-99 216592015687 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216592015688 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216592015689 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216592015690 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 216592015691 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 216592015692 HMMPfam hit to PF02625, XdhC and CoxI family, score 2.9e-30 216592015693 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 216592015694 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 216592015695 Ligand binding site; other site 216592015696 metal-binding site 216592015697 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 216592015698 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216592015699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592015700 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 2.2e-32 216592015701 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.016 216592015702 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592015703 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 216592015704 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 216592015705 active site 216592015706 putative substrate binding pocket [chemical binding]; other site 216592015707 HMMPfam hit to PF01979, Amidohydrolase family, score 4.4e-72 216592015708 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216592015709 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 216592015710 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 216592015711 HMMPfam hit to PF00941, FAD binding domain in molybdopterin deh, score 8.7e-55 216592015712 HMMPfam hit to PF03450, CO dehydrogenase flavoprotein C-termina, score 3e-30 216592015713 additional locus_tag=EC042_3092 216592015714 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydrogen, score 9.6e-40 216592015715 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydroge, score 5.6e-239 216592015716 uracil-xanthine permease; Region: ncs2; TIGR00801 216592015717 HMMPfam hit to PF00860, Permease family, score 7.6e-158 216592015718 12 probable transmembrane helices predicted for EC042_3094 by TMHMM2.0 at aa 103-125, 135-152, 157-179, 194-216, 228-250, 265-282, 289-311, 331-353, 379-401, 416-438, 445-467 and 502-524 216592015719 PS01116 Xanthine/uracil permeases family signature. 216592015720 guanine deaminase; Provisional; Region: PRK09228 216592015721 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 216592015722 active site 216592015723 HMMPfam hit to PF01979, Amidohydrolase family, score 9.2e-92 216592015724 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 216592015725 HMMPfam hit to PF00860, Permease family, score 5.7e-92 216592015726 12 probable transmembrane helices predicted for EC042_3096 by TMHMM2.0 at aa 35-57, 62-84, 91-113, 118-140, 147-169, 179-201, 208-230, 250-272, 341-363, 367-384, 397-419 and 434-453 216592015727 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015728 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 216592015729 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 7.1e-07 216592015730 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592015731 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0081 216592015732 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 216592015733 4Fe-4S binding domain; Region: Fer4; pfam00037 216592015734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216592015735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592015736 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 3.1e-18 216592015737 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0096 216592015738 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.4e-07 216592015739 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592015740 PS00190 Cytochrome c family heme-binding site signature. 216592015741 xanthine permease; Region: pbuX; TIGR03173 216592015742 HMMPfam hit to PF00860, Permease family, score 1.2e-167 216592015743 12 probable transmembrane helices predicted for EC042_3099 by TMHMM2.0 at aa 73-95, 105-127, 132-154, 159-181, 188-210, 225-242, 247-269, 300-322, 376-398, 403-425, 434-451 and 466-488 216592015744 PS01116 Xanthine/uracil permeases family signature. 216592015745 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 216592015746 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 216592015747 active site 216592015748 metal binding site [ion binding]; metal-binding site 216592015749 nudix motif; other site 216592015750 HMMPfam hit to PF00293, NUDIX domain, score 2.8e-16 216592015751 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 216592015752 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216592015753 dimer interface [polypeptide binding]; other site 216592015754 putative anticodon binding site; other site 216592015755 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 216592015756 motif 1; other site 216592015757 active site 216592015758 motif 2; other site 216592015759 motif 3; other site 216592015760 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.2e-206 216592015761 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592015762 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015763 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592015764 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 4.9e-20 216592015765 peptide chain release factor 2; Provisional; Region: PRK08787 216592015766 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216592015767 RF-1 domain; Region: RF-1; pfam00472 216592015768 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1e-71 216592015769 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216592015770 HMMPfam hit to PF03462, PCRF domain, score 1.2e-61 216592015771 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 216592015772 DHH family; Region: DHH; pfam01368 216592015773 DHHA1 domain; Region: DHHA1; pfam02272 216592015774 HMMPfam hit to PF02272, DHHA1 domain, score 2.5e-17 216592015775 HMMPfam hit to PF01368, DHH family, score 9.4e-54 216592015776 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 216592015777 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 216592015778 dimerization domain [polypeptide binding]; other site 216592015779 dimer interface [polypeptide binding]; other site 216592015780 catalytic residues [active] 216592015781 PS00194 Thioredoxin family active site. 216592015782 PS00190 Cytochrome c family heme-binding site signature. 216592015783 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 216592015784 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 216592015785 active site 216592015786 Int/Topo IB signature motif; other site 216592015787 HMMPfam hit to PF00589, Phage integrase family, score 1.5e-76 216592015788 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 2.5e-31 216592015789 flavodoxin FldB; Provisional; Region: PRK12359 216592015790 HMMPfam hit to PF00258, Flavodoxin, score 1.1e-42 216592015791 PS00201 Flavodoxin signature. 216592015792 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 216592015793 HMMPfam hit to PF07254, Protein of unknown function (DUF1434), score 2.3e-113 216592015794 1 probable transmembrane helix predicted for EC042_3107 by TMHMM2.0 at aa 20-51 216592015795 hypothetical protein; Provisional; Region: PRK10878 216592015796 HMMPfam hit to PF03937, TPR repeat region, score 4.8e-40 216592015797 putative global regulator; Reviewed; Region: PRK09559 216592015798 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 216592015799 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 0.00013 216592015800 hemolysin; Provisional; Region: PRK15087 216592015801 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 216592015802 7 probable transmembrane helices predicted for EC042_3111 by TMHMM2.0 at aa 20-42, 46-68, 89-107, 112-134, 139-161, 165-187 and 194-216 216592015803 HMMPfam hit to PF03006, Haemolysin-III related, score 5.8e-63 216592015804 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 216592015805 HMMPfam hit to PF06164, Bacterial protein of unknown function (DUF97, score 1.7e-76 216592015806 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 216592015807 beta-galactosidase; Region: BGL; TIGR03356 216592015808 HMMPfam hit to PF00232, Glycosyl hydrolase family, score 1.2e-144 216592015809 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 216592015810 PS00572 Glycosyl hydrolases family 1 active site. 216592015811 glycine dehydrogenase; Provisional; Region: PRK05367 216592015812 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216592015813 tetramer interface [polypeptide binding]; other site 216592015814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592015815 catalytic residue [active] 216592015816 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216592015817 tetramer interface [polypeptide binding]; other site 216592015818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592015819 catalytic residue [active] 216592015820 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 3.3e-300 216592015821 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 216592015822 lipoyl attachment site [posttranslational modification]; other site 216592015823 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 3.8e-78 216592015824 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216592015825 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 216592015826 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216592015827 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 5.7e-144 216592015828 oxidoreductase; Provisional; Region: PRK08013 216592015829 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 216592015830 HMMPfam hit to PF01360, Monooxygenase, score 1.4e-48 216592015831 PS01304 ubiH/COQ6 monooxygenase family signature. 216592015832 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 216592015833 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 216592015834 HMMPfam hit to PF01360, Monooxygenase, score 6.7e-35 216592015835 PS01304 ubiH/COQ6 monooxygenase family signature. 216592015836 proline aminopeptidase P II; Provisional; Region: PRK10879 216592015837 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 216592015838 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 216592015839 active site 216592015840 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.4e-123 216592015841 PS00491 Aminopeptidase P and proline dipeptidase signature. 216592015842 HMMPfam hit to PF05195, Aminopeptidase P, N-terminal domain, score 4.4e-70 216592015843 hypothetical protein; Reviewed; Region: PRK01736 216592015844 HMMPfam hit to PF03695, Uncharacterised protein family (UPF0149), score 1.4e-127 216592015845 Z-ring-associated protein; Provisional; Region: PRK10972 216592015846 HMMPfam hit to PF05164, Family of unknown function (DUF710), score 1.4e-40 216592015847 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 216592015848 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 216592015849 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.1e-51 216592015850 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 216592015851 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 216592015852 ligand binding site [chemical binding]; other site 216592015853 NAD binding site [chemical binding]; other site 216592015854 tetramer interface [polypeptide binding]; other site 216592015855 catalytic site [active] 216592015856 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 216592015857 L-serine binding site [chemical binding]; other site 216592015858 ACT domain interface; other site 216592015859 HMMPfam hit to PF01842, ACT domain, score 4e-13 216592015860 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 2.1e-98 216592015861 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216592015862 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216592015863 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216592015864 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 2.1e-25 216592015865 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 216592015866 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592015867 active site 216592015868 dimer interface [polypeptide binding]; other site 216592015869 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 4.2e-98 216592015870 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 216592015871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592015872 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 216592015873 putative dimerization interface [polypeptide binding]; other site 216592015874 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.6e-17 216592015875 Predicted helix-turn-helix motif with score 1987.000, SD 5.95 at aa 35-56, sequence RGFERAAQKLCITQSAVSQRIK 216592015876 PS00044 Bacterial regulatory proteins, lysR family signature. 216592015877 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.3e-06 216592015878 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 216592015879 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 216592015880 active site 216592015881 substrate binding site [chemical binding]; other site 216592015882 coenzyme B12 binding site [chemical binding]; other site 216592015883 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216592015884 B12 binding site [chemical binding]; other site 216592015885 cobalt ligand [ion binding]; other site 216592015886 HMMPfam hit to PF01642, Methylmalonyl-CoA mutase, score 0 216592015887 Present in 0157, absent in Uropathogenic, fatty acid degradation cluster, deletion in uropathogenic to create gene fusion 216592015888 Predicted helix-turn-helix motif with score 1058.000, SD 2.79 at aa 337-358, sequence TTIEALAATLGGTQSLHTNAFD 216592015889 PS00544 Methylmalonyl-CoA mutase signature. 216592015890 HMMPfam hit to PF02310, B12 binding domain, score 3.3e-27 216592015891 membrane ATPase/protein kinase; Provisional; Region: PRK09435 216592015892 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 216592015893 Walker A; other site 216592015894 HMMPfam hit to PF03308, ArgK protein, score 9.8e-192 216592015895 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015896 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 216592015897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216592015898 substrate binding site [chemical binding]; other site 216592015899 oxyanion hole (OAH) forming residues; other site 216592015900 trimer interface [polypeptide binding]; other site 216592015901 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 7.1e-27 216592015902 PS00166 Enoyl-CoA hydratase/isomerase signature. 216592015903 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 216592015904 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 216592015905 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 216592015906 HMMPfam hit to PF02550, Acetyl-CoA hydrolase/transferase, score 0 216592015907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592015908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592015909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592015910 dimerization interface [polypeptide binding]; other site 216592015911 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.8e-05 216592015912 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1e-13 216592015913 PS00044 Bacterial regulatory proteins, lysR family signature. 216592015914 Uncharacterized conserved protein [Function unknown]; Region: COG2968 216592015915 oxidative stress defense protein; Provisional; Region: PRK11087 216592015916 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 3.9e-85 216592015917 arginine exporter protein; Provisional; Region: PRK09304 216592015918 HMMPfam hit to PF01810, LysE type translocator, score 5.8e-75 216592015919 6 probable transmembrane helices predicted for EC042_3132 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133, 148-170 and 182-199 216592015920 mechanosensitive channel MscS; Provisional; Region: PRK10334 216592015921 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592015922 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 5.8e-84 216592015923 PS01246 Uncharacterized protein family UPF0003 signature. 216592015924 3 probable transmembrane helices predicted for EC042_3133 by TMHMM2.0 at aa 22-44, 65-87 and 102-124 216592015925 HMMPfam hit to PF05552, Conserved TM helix, score 7.9e-15 216592015926 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216592015927 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 216592015928 active site 216592015929 intersubunit interface [polypeptide binding]; other site 216592015930 zinc binding site [ion binding]; other site 216592015931 Na+ binding site [ion binding]; other site 216592015932 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 1.6e-214 216592015933 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 216592015934 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 216592015935 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 216592015936 Phosphoglycerate kinase; Region: PGK; pfam00162 216592015937 substrate binding site [chemical binding]; other site 216592015938 hinge regions; other site 216592015939 ADP binding site [chemical binding]; other site 216592015940 catalytic site [active] 216592015941 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 1.9e-219 216592015942 PS00111 Phosphoglycerate kinase signature. 216592015943 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 216592015944 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 216592015945 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216592015946 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 3.1e-76 216592015947 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216592015948 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 5.5e-82 216592015949 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 216592015950 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 216592015951 active site 216592015952 PS00017 ATP/GTP-binding site motif A (P-loop). 216592015953 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 216592015954 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 216592015955 HMMPfam hit to PF05068, Mannitol repressor, score 3e-113 216592015956 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 216592015957 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 216592015958 putative active site [active] 216592015959 HMMPfam hit to PF03320, Bacterial fructose-1,6-bisphosphatase, gl, score 7.9e-248 216592015960 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 216592015961 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592015962 putative NAD(P) binding site [chemical binding]; other site 216592015963 catalytic Zn binding site [ion binding]; other site 216592015964 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.3e-39 216592015965 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 216592015966 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 216592015967 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 216592015968 active site 216592015969 P-loop; other site 216592015970 phosphorylation site [posttranslational modification] 216592015971 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 4.4e-25 216592015972 8 probable transmembrane helices predicted for EC042_3141 by TMHMM2.0 at aa 21-43, 53-75, 82-104, 136-158, 214-236, 246-264, 271-293 and 313-335 216592015973 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.7e-30 216592015974 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592015975 active site 216592015976 phosphorylation site [posttranslational modification] 216592015977 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 4.9e-68 216592015978 PS00372 PTS EIIA domains phosphorylation site signature 2. 216592015979 transketolase; Reviewed; Region: PRK12753 216592015980 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216592015981 TPP-binding site [chemical binding]; other site 216592015982 dimer interface [polypeptide binding]; other site 216592015983 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216592015984 PYR/PP interface [polypeptide binding]; other site 216592015985 dimer interface [polypeptide binding]; other site 216592015986 TPP binding site [chemical binding]; other site 216592015987 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216592015988 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 2.4e-19 216592015989 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 5.1e-61 216592015990 PS00802 Transketolase signature 2. 216592015991 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.6e-259 216592015992 PS00801 Transketolase signature 1. 216592015993 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 216592015994 HMMPfam hit to PF01435, Peptidase family M48, score 4.8e-25 216592015995 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 216592015996 agmatinase; Region: agmatinase; TIGR01230 216592015997 oligomer interface [polypeptide binding]; other site 216592015998 putative active site [active] 216592015999 Mn binding site [ion binding]; other site 216592016000 HMMPfam hit to PF00491, Arginase family, score 3.2e-141 216592016001 PS01053 Arginase family signature 3. 216592016002 PS00148 Arginase family signature 2. 216592016003 PS00147 Arginase family signature 1. 216592016004 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 216592016005 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 216592016006 dimer interface [polypeptide binding]; other site 216592016007 active site 216592016008 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592016009 catalytic residues [active] 216592016010 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 216592016011 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 3.2e-57 216592016012 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 2.9e-120 216592016013 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 216592016014 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 216592016015 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 216592016016 1 probable transmembrane helix predicted for EC042_3148 by TMHMM2.0 at aa 29-48 216592016017 S-adenosylmethionine synthetase; Validated; Region: PRK05250 216592016018 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 216592016019 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 216592016020 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 216592016021 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 5.4e-64 216592016022 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 1.8e-85 216592016023 PS00376 S-adenosylmethionine synthetase signature 1. 216592016024 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 3.5e-91 216592016025 PS00377 S-adenosylmethionine synthetase signature 2. 216592016026 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 216592016027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592016028 putative substrate translocation pore; other site 216592016029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592016030 12 probable transmembrane helices predicted for EC042_3150 by TMHMM2.0 at aa 20-42, 62-81, 88-107, 112-134, 146-163, 173-195, 256-278, 293-315, 322-344, 354-376, 389-411 and 421-440 216592016031 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4.6e-183 216592016032 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.2e-43 216592016033 PS00217 Sugar transport proteins signature 2. 216592016034 PS00216 Sugar transport proteins signature 1. 216592016035 hypothetical protein; Provisional; Region: PRK04860 216592016036 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 216592016037 HMMPfam hit to PF03926, Putative metallopeptidase (SprT family), score 2.1e-95 216592016038 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592016039 DNA-specific endonuclease I; Provisional; Region: PRK15137 216592016040 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 216592016041 HMMPfam hit to PF04231, Endonuclease I, score 1.2e-140 216592016042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 216592016043 RNA methyltransferase, RsmE family; Region: TIGR00046 216592016044 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 1.7e-40 216592016045 PS00215 Mitochondrial energy transfer proteins signature. 216592016046 glutathione synthetase; Provisional; Region: PRK05246 216592016047 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 216592016048 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 216592016049 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-termi, score 1.1e-83 216592016050 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-bin, score 5.9e-93 216592016051 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592016052 hypothetical protein; Validated; Region: PRK00228 216592016053 HMMPfam hit to PF02622, Uncharacterized ACR, COG1678, score 2.6e-99 216592016054 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 216592016055 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 5.4e-75 216592016056 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 216592016057 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 216592016058 Walker A motif; other site 216592016059 ATP binding site [chemical binding]; other site 216592016060 Walker B motif; other site 216592016061 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1.8e-26 216592016062 PS00662 Bacterial type II secretion system protein E signature. 216592016063 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016064 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 216592016065 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592016066 catalytic residue [active] 216592016067 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 2.8e-43 216592016068 PS01211 Uncharacterized protein family UPF0001 signature. 216592016069 YGGT family; Region: YGGT; pfam02325 216592016070 YGGT family; Region: YGGT; pfam02325 216592016071 HMMPfam hit to PF02325, YGGT family, score 8.4e-31 216592016072 4 probable transmembrane helices predicted for EC042_3159 by TMHMM2.0 at aa 5-27, 67-89, 96-118 and 144-166 216592016073 HMMPfam hit to PF02325, YGGT family, score 2.6e-30 216592016074 hypothetical protein; Validated; Region: PRK05090 216592016075 HMMPfam hit to PF02594, Uncharacterized ACR, YggU family COG1872, score 1.4e-38 216592016076 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 216592016077 active site 216592016078 dimerization interface [polypeptide binding]; other site 216592016079 HMMPfam hit to PF01725, Ham1 family, score 1.7e-120 216592016080 HemN family oxidoreductase; Provisional; Region: PRK05660 216592016081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592016082 FeS/SAM binding site; other site 216592016083 HemN C-terminal domain; Region: HemN_C; pfam06969 216592016084 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.3e-28 216592016085 HMMPfam hit to PF06969, HemN C-terminal region, score 6e-20 216592016086 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 216592016087 HMMPfam hit to PF06717, Protein of unknown function (DUF1202), score 7.3e-274 216592016088 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 216592016089 homodimer interface [polypeptide binding]; other site 216592016090 active site 216592016091 HMMPfam hit to PF00710, Asparaginase, score 1.1e-181 216592016092 PS00445 FGGY family of carbohydrate kinases signature 2. 216592016093 PS00917 Asparaginase / glutaminase active site signature 2. 216592016094 PS00144 Asparaginase / glutaminase active site signature 1. 216592016095 1 probable transmembrane helix predicted for EC042_3164 by TMHMM2.0 at aa 7-29 216592016096 hypothetical protein; Provisional; Region: PRK10626 216592016097 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 216592016098 hypothetical protein; Provisional; Region: PRK11702 216592016099 HMMPfam hit to PF04320, Protein with unknown function (DUF469), score 1.5e-86 216592016100 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 216592016101 HMMPfam hit to PF02390, Putative methyltransferase, score 1.1e-100 216592016102 adenine DNA glycosylase; Provisional; Region: PRK10880 216592016103 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216592016104 minor groove reading motif; other site 216592016105 helix-hairpin-helix signature motif; other site 216592016106 substrate binding pocket [chemical binding]; other site 216592016107 active site 216592016108 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 216592016109 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 216592016110 DNA binding and oxoG recognition site [nucleotide binding] 216592016111 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 1.6e-23 216592016112 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.3e-05 216592016113 PS01155 Endonuclease III family signature. 216592016114 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 108-129, sequence ETFEEVAALPGVGRSTAGAILS 216592016115 PS00764 Endonuclease III iron-sulfur binding region signature. 216592016116 oxidative damage protection protein; Provisional; Region: PRK05408 216592016117 HMMPfam hit to PF04362, Protein of unknown function (DUF495), score 3e-72 216592016118 murein transglycosylase C; Provisional; Region: mltC; PRK11671 216592016119 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 216592016120 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592016121 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592016122 catalytic residue [active] 216592016123 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592016124 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 7.1e-47 216592016125 PS00922 Prokaryotic transglycosylases signature. 216592016126 nucleoside transporter; Region: 2A0110; TIGR00889 216592016127 HMMPfam hit to PF03825, Nucleoside H+ symporter, score 5.4e-302 216592016128 12 probable transmembrane helices predicted for EC042_3171 by TMHMM2.0 at aa 25-47, 57-79, 86-105, 110-132, 153-175, 179-201, 227-249, 269-291, 298-317, 327-349, 362-381 and 396-418 216592016129 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.7e-08 216592016130 ornithine decarboxylase; Provisional; Region: PRK13578 216592016131 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 216592016132 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 216592016133 homodimer interface [polypeptide binding]; other site 216592016134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592016135 catalytic residue [active] 216592016136 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216592016137 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 1.8e-86 216592016138 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 0 216592016139 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 216592016140 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 4.5e-33 216592016141 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 216592016142 HMMPfam hit to PF04474, Protein of unknown function (DUF554), score 6.8e-137 216592016143 6 probable transmembrane helices predicted for EC042_3173 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167, 177-199 and 211-233 216592016144 Genomic island 2. Sequence divergence between 0157 and Uropathogenic strains, carries putative sulfatase and Tia homologue-epithelial adherence and invasion protein, helicase, plasmid replication proteins, hypothetical protein, exported/membrane proteins, bacteriocin biosynthesis-also may have a role in siderophore production, putative acetyltransferase) 216592016145 integrase; Provisional; Region: PRK09692 216592016146 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592016147 active site 216592016148 Int/Topo IB signature motif; other site 216592016149 HMMPfam hit to PF00589, Phage integrase family, score 3.6e-33 216592016150 PS00018 EF-hand calcium-binding domain. 216592016151 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 216592016152 Sulfatase; Region: Sulfatase; cl17466 216592016153 HMMPfam hit to PF00884, Sulfatase, score 1.4e-34 216592016154 4 probable transmembrane helices predicted for EC042_3175 by TMHMM2.0 at aa 10-32, 45-67, 87-109 and 122-144 216592016155 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216592016156 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 9.5e-05 216592016157 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 216592016158 tellurite resistance protein terB; Region: terB; cd07176 216592016159 putative metal binding site [ion binding]; other site 216592016160 2 probable transmembrane helices predicted for EC042_3177 by TMHMM2.0 at aa 4-18 and 90-112 216592016161 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 216592016162 AAA ATPase domain; Region: AAA_16; pfam13191 216592016163 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592016165 ATP binding site [chemical binding]; other site 216592016166 putative Mg++ binding site [ion binding]; other site 216592016167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592016168 nucleotide binding region [chemical binding]; other site 216592016169 ATP-binding site [chemical binding]; other site 216592016170 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.8e-35 216592016171 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016172 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.6e-11 216592016173 PerC transcriptional activator; Region: PerC; pfam06069 216592016174 HMMPfam hit to PF06069, PerC transcriptional activator, score 9.3e-57 216592016175 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216592016176 ParB-like nuclease domain; Region: ParBc; pfam02195 216592016177 HMMPfam hit to PF02195, ParB-like nuclease domain, score 4.5e-09 216592016178 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 216592016179 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592016180 Active Sites [active] 216592016181 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 216592016183 1 probable transmembrane helix predicted for EC042_3185 by TMHMM2.0 at aa 73-95 216592016184 HMMPfam hit to PF06812, ImpA-related N-terminal, score 1.1e-19 216592016185 Nuclease-related domain; Region: NERD; pfam08378 216592016186 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216592016187 Family description; Region: UvrD_C_2; pfam13538 216592016188 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016189 Integrase core domain; Region: rve_3; pfam13683 216592016190 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592016191 Predicted helix-turn-helix motif with score 1091.000, SD 2.90 at aa 142-163, sequence LPYQQVAREVKAPRERLKYALE 216592016192 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592016193 additional locus_tag=EC042_3193 216592016194 2 probable transmembrane helices predicted for EC042_3193 by TMHMM2.0 at aa 37-59 and 69-91 216592016195 2 probable transmembrane helices predicted for EC042_3194 by TMHMM2.0 at aa 5-22 and 54-76 216592016196 2 probable transmembrane helices predicted for EC042_3195 by TMHMM2.0 at aa 20-42 and 83-105 216592016197 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 216592016198 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 216592016199 putative active site [active] 216592016200 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216592016201 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 216592016202 Walker A/P-loop; other site 216592016203 ATP binding site [chemical binding]; other site 216592016204 Q-loop/lid; other site 216592016205 ABC transporter signature motif; other site 216592016206 Walker B; other site 216592016207 D-loop; other site 216592016208 H-loop/switch region; other site 216592016209 HMMPfam hit to PF00005, ABC transporter, score 1.7e-55 216592016210 PS00211 ABC transporters family signature. 216592016211 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016212 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.1e-48 216592016213 5 probable transmembrane helices predicted for EC042_3196 by TMHMM2.0 at aa 185-207, 217-239, 295-317, 321-343 and 403-425 216592016214 HMMPfam hit to PF03412, Peptidase C39 family, score 6.3e-52 216592016215 HlyD family secretion protein; Region: HlyD; pfam00529 216592016216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592016217 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592016218 PS00543 HlyD family secretion proteins signature. 216592016219 HMMPfam hit to PF00529, HlyD family secretion protein, score 3e-50 216592016220 1 probable transmembrane helix predicted for EC042_3197 by TMHMM2.0 at aa 20-42 216592016221 RTX toxin acyltransferase family; Region: HlyC; pfam02794 216592016222 PS00073 Acyl-CoA dehydrogenases signature 2. 216592016223 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 216592016224 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 216592016225 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 216592016226 HMMPfam hit to PF00756, Putative esterase, score 5.4e-34 216592016227 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 216592016228 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 216592016229 homodimer interface [polypeptide binding]; other site 216592016230 TDP-binding site; other site 216592016231 HMMPfam hit to PF06722, Protein of unknown function (DUF1205), score 9.1e-37 216592016232 1 probable transmembrane helix predicted for EC042_3203 by TMHMM2.0 at aa 61-83 216592016233 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 216592016234 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 4.5e-18 216592016235 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592016236 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592016237 Winged helix-turn helix; Region: HTH_29; pfam13551 216592016238 Homeodomain-like domain; Region: HTH_32; pfam13565 216592016239 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 216592016240 Predicted helix-turn-helix motif with score 1871.000, SD 5.56 at aa 19-40, sequence HGISAASEAFGVSCRTLYWWRQ 216592016241 1 probable transmembrane helix predicted for EC042_3208 by TMHMM2.0 at aa 6-25 216592016242 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 216592016243 putative trimer interface [polypeptide binding]; other site 216592016244 putative active site [active] 216592016245 putative substrate binding site [chemical binding]; other site 216592016246 putative CoA binding site [chemical binding]; other site 216592016247 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 216592016248 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 16 216592016249 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.024 216592016250 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.67 216592016251 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.26 216592016252 PS01186 EGF-like domain signature 2. 216592016254 HMMPfam hit to PF01527, Transposase, score 1.2e-22 216592016255 Predicted helix-turn-helix motif with score 1195.000, SD 3.26 at aa 25-46, sequence LSISEGASRLSLPEGTLGQWVT 216592016256 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216592016257 Helix-turn-helix domain; Region: HTH_38; pfam13936 216592016258 Integrase core domain; Region: rve; pfam00665 216592016259 HMMPfam hit to PF00665, Integrase core domain, score 2.8e-33 216592016260 PS01043 Transposases, IS30 family, signature. 216592016261 Predicted helix-turn-helix motif with score 1859.000, SD 5.52 at aa 75-96, sequence MSIRAIATALNRSPSTISREVQ 216592016262 Predicted helix-turn-helix motif with score 1036.000, SD 2.72 at aa 21-42, sequence TGFSEIANILGSKPGTIFTMLR 216592016263 putative transposase OrfB; Reviewed; Region: PHA02517 216592016264 Integrase core domain; Region: rve; pfam00665 216592016265 Integrase core domain; Region: rve_3; pfam13683 216592016266 HMMPfam hit to PF00665, Integrase core domain, score 2.6e-44 216592016267 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592016268 Predicted helix-turn-helix motif with score 1008.000, SD 2.62 at aa 100-121, sequence KHLFWLAEKLGRTPYSVACKVR 216592016269 Predicted GTPase [General function prediction only]; Region: COG3596 216592016270 YfjP GTPase; Region: YfjP; cd11383 216592016271 G1 box; other site 216592016272 GTP/Mg2+ binding site [chemical binding]; other site 216592016273 Switch I region; other site 216592016274 G2 box; other site 216592016275 Switch II region; other site 216592016276 G3 box; other site 216592016277 G4 box; other site 216592016278 G5 box; other site 216592016279 HMMPfam hit to PF01926, GTPase of unknown function, score 3e-19 216592016280 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016281 HTH domain; Region: HTH_11; cl17392 216592016282 WYL domain; Region: WYL; pfam13280 216592016283 Predicted helix-turn-helix motif with score 1645.000, SD 4.79 at aa 28-49, sequence LSLKTLSDEFGVTERTLQRDFH 216592016284 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 216592016285 HMMPfam hit to PF06006, Bacterial protein of unknown function (DUF90, score 4.1e-46 216592016286 Domain of unknown function (DUF932); Region: DUF932; pfam06067 216592016287 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 2e-216 216592016288 Antirestriction protein; Region: Antirestrict; pfam03230 216592016289 HMMPfam hit to PF03230, Antirestriction protein, score 7.3e-52 216592016290 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 216592016291 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216592016292 MPN+ (JAMM) motif; other site 216592016293 Zinc-binding site [ion binding]; other site 216592016294 HMMPfam hit to PF04002, RadC, DNA repair protein, score 1.6e-82 216592016295 PS01302 DNA repair protein radC family signature. 216592016296 Protein of unknown function (DUF987); Region: DUF987; pfam06174 216592016297 HMMPfam hit to PF06174, Protein of unknown function (DUF987), score 3.7e-56 216592016298 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 216592016299 HMMPfam hit to PF06154, YagB/YeeU/YfjZ family, score 9.8e-87 216592016300 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 216592016301 HMMPfam hit to PF06755, Protein of unknown function (DUF1219), score 1.2e-103 216592016302 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 216592016303 HMMPfam hit to PF06117, Enterobacterial protein of unknown function, score 7.5e-50 216592016304 Methyltransferase domain; Region: Methyltransf_27; pfam13708 216592016305 Partial present in Uropathogenic, absent in 0157, misc. island, capsule cluster, type II secretion system, accessory colonization factor AcfD , glycolate catabolism cluster, misc. secondary metabolism(?) 216592016306 capsular biosynthesis locus 216592016307 KpsF/GutQ family protein; Region: kpsF; TIGR00393 216592016308 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 216592016309 putative active site [active] 216592016310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216592016311 HMMPfam hit to PF01380, SIS domain, score 1.3e-39 216592016312 HMMPfam hit to PF00571, CBS domain, score 7.5e-09 216592016313 HMMPfam hit to PF00571, CBS domain, score 4.8e-06 216592016314 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 216592016315 HMMPfam hit to PF02706, Chain length determinant protein, score 0.067 216592016316 2 probable transmembrane helices predicted for EC042_3231 by TMHMM2.0 at aa 28-47 and 355-377 216592016317 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 216592016318 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216592016319 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 5.5e-54 216592016320 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 216592016321 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 216592016322 Ligand binding site; other site 216592016323 oligomer interface; other site 216592016324 HMMPfam hit to PF02348, Cytidylyltransferase, score 5.6e-92 216592016325 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 216592016326 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 1e-129 216592016327 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 2.4e-133 216592016328 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 216592016329 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 216592016330 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 3.1e-148 216592016331 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216592016332 trimer interface [polypeptide binding]; other site 216592016333 active site 216592016334 substrate binding site [chemical binding]; other site 216592016335 CoA binding site [chemical binding]; other site 216592016336 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 216592016337 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.041 216592016338 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 216592016339 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 216592016340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216592016341 active site 216592016342 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216592016343 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 216592016344 Walker A/P-loop; other site 216592016345 ATP binding site [chemical binding]; other site 216592016346 Q-loop/lid; other site 216592016347 ABC transporter signature motif; other site 216592016348 Walker B; other site 216592016349 D-loop; other site 216592016350 H-loop/switch region; other site 216592016351 HMMPfam hit to PF00005, ABC transporter, score 2.4e-22 216592016352 PS00211 ABC transporters family signature. 216592016353 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016354 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 216592016355 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216592016356 6 probable transmembrane helices predicted for EC042_3240 by TMHMM2.0 at aa 31-53, 63-85, 106-128, 143-165, 174-196 and 228-247 216592016357 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.7e-28 216592016358 PS00890 ABC-2 type transport system integral membrane proteins signature. 216592016359 type II secretion system 216592016360 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 216592016361 HMMPfam hit to PF04612, General secretion pathway, M protein, score 1.8e-72 216592016362 1 probable transmembrane helix predicted for EC042_3242 by TMHMM2.0 at aa 38-60 216592016363 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 216592016364 GspL-like protein; Provisional; Region: PRK09662 216592016365 HMMPfam hit to PF05134, General secretion pathway protein L (GspL), score 4.9e-123 216592016366 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 216592016367 HMMPfam hit to PF03934, General secretion pathway protein K, score 5.4e-74 216592016368 1 probable transmembrane helix predicted for EC042_3244 by TMHMM2.0 at aa 9-31 216592016369 type II secretion system protein J; Region: gspJ; TIGR01711 216592016370 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 216592016371 type II secretion system protein I; Region: gspI; TIGR01707 216592016372 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 216592016373 HMMPfam hit to PF02501, Bacterial type II secretion system protein I, score 1e-24 216592016374 1 probable transmembrane helix predicted for EC042_3246 by TMHMM2.0 at aa 10-32 216592016375 PS00409 Prokaryotic N-terminal methylation site. 216592016376 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 216592016377 Type II transport protein GspH; Region: GspH; pfam12019 216592016378 1 probable transmembrane helix predicted for EC042_3247 by TMHMM2.0 at aa 7-29 216592016379 PS00409 Prokaryotic N-terminal methylation site. 216592016380 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 216592016381 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 216592016382 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 216592016383 1 probable transmembrane helix predicted for EC042_3248 by TMHMM2.0 at aa 12-34 216592016384 PS00409 Prokaryotic N-terminal methylation site. 216592016385 type II secretion system protein F; Region: GspF; TIGR02120 216592016386 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216592016387 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216592016388 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.8e-15 216592016389 3 probable transmembrane helices predicted for EC042_3249 by TMHMM2.0 at aa 172-194, 221-240 and 372-394 216592016390 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 3.6e-24 216592016391 PS00874 Bacterial type II secretion system protein F signature. 216592016392 type II secretion system protein E; Region: type_II_gspE; TIGR02533 216592016393 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216592016394 Walker A motif; other site 216592016395 ATP binding site [chemical binding]; other site 216592016396 Walker B motif; other site 216592016397 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 8.2e-146 216592016398 PS00662 Bacterial type II secretion system protein E signature. 216592016399 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016400 type II secretion system protein D; Region: type_II_gspD; TIGR02517 216592016401 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216592016402 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216592016403 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216592016404 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 216592016405 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 2.2e-84 216592016406 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 5.6e-11 216592016407 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 6.5e-15 216592016408 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.6e-09 216592016409 putative type II secretion protein GspC; Provisional; Region: PRK09681 216592016410 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 216592016411 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592016412 1 probable transmembrane helix predicted for EC042_3252 by TMHMM2.0 at aa 43-65 216592016413 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592016414 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 216592016415 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 216592016416 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 216592016417 7 probable transmembrane helices predicted for EC042_3254 by TMHMM2.0 at aa 10-32, 102-120, 124-141, 148-167, 177-196, 209-231 and 246-268 216592016418 HMMPfam hit to PF01478, Type IV leader peptidase family, score 3.4e-23 216592016419 HMMPfam hit to PF06750, Bacterial Peptidase A24 N-terminal doma, score 1.1e-48 216592016420 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 216592016421 Peptidase M60-like family; Region: M60-like; pfam13402 216592016422 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592016423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592016424 glycolate transporter; Provisional; Region: PRK09695 216592016425 L-lactate permease; Region: Lactate_perm; cl00701 216592016426 13 probable transmembrane helices predicted for EC042_3257 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 129-151, 158-180, 190-212, 224-242, 252-269, 307-326, 377-399, 411-430, 440-462 and 537-559 216592016427 HMMPfam hit to PF02652, L-lactate permease, score 5.8e-277 216592016428 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 216592016429 active site 216592016430 HMMPfam hit to PF01274, Malate synthase, score 0 216592016431 hypothetical protein; Provisional; Region: PRK09732 216592016432 HMMPfam hit to PF03928, Domain of unknown function (DUF336), score 2.1e-57 216592016433 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 216592016434 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592016435 Cysteine-rich domain; Region: CCG; pfam02754 216592016436 Cysteine-rich domain; Region: CCG; pfam02754 216592016437 HMMPfam hit to PF02754, Cysteine-rich domain, score 3.7e-17 216592016438 HMMPfam hit to PF02754, Cysteine-rich domain, score 8.5e-10 216592016439 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00086 216592016440 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592016441 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0043 216592016442 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592016443 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 216592016444 FAD binding domain; Region: FAD_binding_4; pfam01565 216592016445 HMMPfam hit to PF01565, FAD binding domain, score 4.6e-27 216592016446 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 216592016447 FAD binding domain; Region: FAD_binding_4; pfam01565 216592016448 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 5.1e-89 216592016449 HMMPfam hit to PF01565, FAD binding domain, score 2.2e-57 216592016450 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 216592016451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592016452 DNA-binding site [nucleotide binding]; DNA binding site 216592016453 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592016454 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 9.9e-13 216592016455 PS00043 Bacterial regulatory proteins, gntR family signature. 216592016456 HMMPfam hit to PF07729, FCD domain, score 3.3e-32 216592016457 acyl-CoA synthetase; Validated; Region: PRK09192 216592016458 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 216592016459 acyl-activating enzyme (AAE) consensus motif; other site 216592016460 active site 216592016461 HMMPfam hit to PF00501, AMP-binding enzyme, score 6.4e-71 216592016462 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216592016463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216592016464 NAD(P) binding site [chemical binding]; other site 216592016465 active site 216592016466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216592016467 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 1.9e-10 216592016468 PS00012 Phosphopantetheine attachment site. 216592016469 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216592016470 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216592016471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592016472 catalytic residue [active] 216592016473 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5e-15 216592016474 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216592016475 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 216592016476 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216592016477 6 probable transmembrane helices predicted for EC042_3269 by TMHMM2.0 at aa 12-34, 59-81, 94-116, 275-294, 301-323 and 333-355 216592016478 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 1.9e-53 216592016479 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216592016480 Predicted permeases [General function prediction only]; Region: COG0795 216592016481 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 8.9e-36 216592016482 5 probable transmembrane helices predicted for EC042_3270 by TMHMM2.0 at aa 15-32, 52-74, 102-121, 294-313 and 323-345 216592016483 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 216592016484 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016485 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216592016486 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216592016487 8 probable transmembrane helices predicted for EC042_3273 by TMHMM2.0 at aa 36-58, 96-118, 133-155, 176-198, 260-282, 312-334, 354-376 and 396-418 216592016488 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 2.7e-05 216592016489 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 216592016490 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 216592016491 active site 216592016492 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016493 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 216592016494 TMP-binding site; other site 216592016495 ATP-binding site [chemical binding]; other site 216592016496 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 216592016497 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 216592016498 TMP-binding site; other site 216592016499 ATP-binding site [chemical binding]; other site 216592016500 PS00017 ATP/GTP-binding site motif A (P-loop). 216592016501 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216592016502 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216592016503 10 probable transmembrane helices predicted for EC042_3277 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-140, 155-177, 207-224, 234-256, 381-403, 418-440 and 474-496 216592016504 HMMPfam hit to PF01384, Phosphate transporter family, score 1.2e-113 216592016505 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592016506 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 216592016507 CHAP domain; Region: CHAP; pfam05257 216592016508 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 216592016509 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 2e-22 216592016510 HMMPfam hit to PF05257, CHAP domain, score 5.1e-36 216592016511 1 probable transmembrane helix predicted for EC042_3278 by TMHMM2.0 at aa 67-86 216592016512 putative S-transferase; Provisional; Region: PRK11752 216592016513 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 216592016514 C-terminal domain interface [polypeptide binding]; other site 216592016515 GSH binding site (G-site) [chemical binding]; other site 216592016516 dimer interface [polypeptide binding]; other site 216592016517 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 216592016518 dimer interface [polypeptide binding]; other site 216592016519 N-terminal domain interface [polypeptide binding]; other site 216592016520 active site 216592016521 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 0.00015 216592016522 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 216592016523 HMMPfam hit to PF01455, HupF/HypC family, score 5e-41 216592016524 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 216592016525 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 216592016526 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 216592016527 HMMPfam hit to PF01155, Hydrogenase expression/synthesis hypA family, score 1e-64 216592016528 PS01249 Hydrogenases expression/synthesis hypA family signature. 216592016529 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 216592016530 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 216592016531 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 216592016532 putative substrate-binding site; other site 216592016533 nickel binding site [ion binding]; other site 216592016534 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 4.2e-51 216592016535 hydrogenase 2 large subunit; Provisional; Region: PRK10467 216592016536 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 216592016537 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, score 0 216592016538 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 216592016539 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 216592016540 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 216592016541 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 216592016542 10 probable transmembrane helices predicted for EC042_3285 by TMHMM2.0 at aa 13-32, 52-74, 86-108, 128-150, 171-193, 208-227, 246-268, 283-302, 315-337 and 352-374 216592016543 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 0.00068 216592016544 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 216592016545 4Fe-4S binding domain; Region: Fer4_6; pfam12837 216592016546 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.7e-06 216592016547 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592016548 hydrogenase 2 small subunit; Provisional; Region: PRK10468 216592016549 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 216592016550 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 216592016551 1 probable transmembrane helix predicted for EC042_3287 by TMHMM2.0 at aa 332-354 216592016552 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 0.00018 216592016553 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 216592016555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592016556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592016557 active site 216592016558 catalytic tetrad [active] 216592016559 HMMPfam hit to PF00248, Aldo/keto reductase family, score 3.4e-89 216592016560 hypothetical protein; Provisional; Region: PRK05208 216592016561 HMMPfam hit to PF03350, Uncharacterized protein family, UPF0114, score 9.7e-124 216592016562 3 probable transmembrane helices predicted for EC042_3293 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 216592016563 oxidoreductase; Provisional; Region: PRK07985 216592016564 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 216592016565 NAD binding site [chemical binding]; other site 216592016566 metal binding site [ion binding]; metal-binding site 216592016567 active site 216592016568 HMMPfam hit to PF00106, short chain dehydrogenase, score 3.4e-63 216592016569 PS00061 Short-chain dehydrogenases/reductases family signature. 216592016570 biopolymer transport protein ExbD; Provisional; Region: PRK11267 216592016571 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 216592016572 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 4e-20 216592016573 1 probable transmembrane helix predicted for EC042_3295 by TMHMM2.0 at aa 20-42 216592016574 biopolymer transport protein ExbB; Provisional; Region: PRK10414 216592016575 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.2e-58 216592016576 3 probable transmembrane helices predicted for EC042_3296 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 216592016577 cystathionine beta-lyase; Provisional; Region: PRK08114 216592016578 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216592016579 homodimer interface [polypeptide binding]; other site 216592016580 substrate-cofactor binding pocket; other site 216592016581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592016582 catalytic residue [active] 216592016583 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 5.4e-187 216592016584 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 216592016585 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216592016586 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216592016587 4 probable transmembrane helices predicted for EC042_3298 by TMHMM2.0 at aa 26-48, 68-90, 158-180 and 190-212 216592016588 HMMPfam hit to PF00597, DedA family, score 3.1e-65 216592016589 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216592016590 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216592016591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592016592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592016593 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.6e-06 216592016594 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2e-09 216592016595 Predicted helix-turn-helix motif with score 1287.000, SD 3.57 at aa 284-305, sequence LSVEQLAAEANMSVSAFHHNFK 216592016596 HMMPfam hit to PF06719, AraC-type transcriptional regulator N-termin, score 2.9e-77 216592016597 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 216592016598 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 216592016599 dimer interface [polypeptide binding]; other site 216592016600 active site 216592016601 metal binding site [ion binding]; metal-binding site 216592016602 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.9e-44 216592016603 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592016604 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592016605 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592016606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216592016607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216592016608 active site 216592016609 catalytic tetrad [active] 216592016610 HMMPfam hit to PF00248, Aldo/keto reductase family, score 1e-128 216592016611 PS00798 Aldo/keto reductase family signature 1. 216592016612 PS00062 Aldo/keto reductase family signature 2. 216592016613 Predicted helix-turn-helix motif with score 1106.000, SD 2.95 at aa 200-221, sequence KVIRDLADKYGKTPAQIVIRWH 216592016614 PS00063 Aldo/keto reductase family putative active site signature. 216592016615 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 216592016616 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 216592016617 putative outer membrane lipoprotein; Provisional; Region: PRK09973 216592016618 1 probable transmembrane helix predicted for EC042_3303 by TMHMM2.0 at aa 4-21 216592016619 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592016620 hypothetical protein; Provisional; Region: PRK01254 216592016621 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 216592016622 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 216592016623 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.6e-12 216592016624 PS01278 Uncharacterized protein family UPF0004 signature. 216592016625 FtsI repressor; Provisional; Region: PRK10883 216592016626 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216592016627 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216592016628 HMMPfam hit to PF07731, Multicopper oxidase, score 8e-17 216592016629 HMMPfam hit to PF07732, Multicopper oxidase, score 8.4e-40 216592016630 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 216592016631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216592016632 putative acyl-acceptor binding pocket; other site 216592016633 HMMPfam hit to PF01553, Acyltransferase, score 1.7e-48 216592016634 1 probable transmembrane helix predicted for EC042_3306 by TMHMM2.0 at aa 2-24 216592016635 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 216592016636 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216592016637 CAP-like domain; other site 216592016638 active site 216592016639 primary dimer interface [polypeptide binding]; other site 216592016640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216592016641 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.2e-06 216592016642 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3e-05 216592016643 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 3.5e-265 216592016644 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 216592016645 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 1.4e-41 216592016646 TIGR00156 family protein; Region: TIGR00156 216592016647 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 5.5e-83 216592016648 1 probable transmembrane helix predicted for EC042_3310 by TMHMM2.0 at aa 13-35 216592016649 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 216592016650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592016651 active site 216592016652 phosphorylation site [posttranslational modification] 216592016653 intermolecular recognition site; other site 216592016654 dimerization interface [polypeptide binding]; other site 216592016655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592016656 DNA binding site [nucleotide binding] 216592016657 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.6e-29 216592016658 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 7.2e-23 216592016659 sensor protein QseC; Provisional; Region: PRK10337 216592016660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592016661 dimer interface [polypeptide binding]; other site 216592016662 phosphorylation site [posttranslational modification] 216592016663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592016664 ATP binding site [chemical binding]; other site 216592016665 Mg2+ binding site [ion binding]; other site 216592016666 G-X-G motif; other site 216592016667 2 probable transmembrane helices predicted for EC042_3312 by TMHMM2.0 at aa 10-32 and 160-182 216592016668 HMMPfam hit to PF00672, HAMP domain, score 2.4e-07 216592016669 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-15 216592016670 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 7.1e-24 216592016671 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 216592016672 HMMPfam hit to PF02525, Flavodoxin-like fold, score 2.1e-75 216592016673 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216592016674 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 2.1e-13 216592016675 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216592016676 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216592016677 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216592016678 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 216592016679 HMMPfam hit to PF01380, SIS domain, score 2.4e-09 216592016680 Predicted helix-turn-helix motif with score 1171.000, SD 3.18 at aa 44-65, sequence QTAMEIAATLNTSDATVIRAIQ 216592016681 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216592016682 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216592016683 siderophore binding site; other site 216592016684 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.4e-08 216592016685 1 probable transmembrane helix predicted for EC042_3316 by TMHMM2.0 at aa 13-35 216592016686 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 216592016687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592016688 ABC-ATPase subunit interface; other site 216592016689 dimer interface [polypeptide binding]; other site 216592016690 putative PBP binding regions; other site 216592016691 HMMPfam hit to PF01032, FecCD transport family, score 1.5e-75 216592016692 9 probable transmembrane helices predicted for EC042_3317 by TMHMM2.0 at aa 4-26, 55-77, 109-131, 138-160, 180-202, 209-228, 232-254, 261-283 and 298-317 216592016693 PS00012 Phosphopantetheine attachment site. 216592016694 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592016695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592016696 dimer interface [polypeptide binding]; other site 216592016697 putative PBP binding regions; other site 216592016698 ABC-ATPase subunit interface; other site 216592016699 9 probable transmembrane helices predicted for EC042_3318 by TMHMM2.0 at aa 5-27, 55-77, 90-112, 117-136, 148-167, 195-217, 238-260, 275-297 and 304-326 216592016700 HMMPfam hit to PF01032, FecCD transport family, score 2.9e-103 216592016701 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216592016702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592016703 Walker A/P-loop; other site 216592016704 ATP binding site [chemical binding]; other site 216592016705 Q-loop/lid; other site 216592016706 ABC transporter signature motif; other site 216592016707 Walker B; other site 216592016708 D-loop; other site 216592016709 H-loop/switch region; other site 216592016710 HMMPfam hit to PF00005, ABC transporter, score 2e-31 216592016711 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216592016712 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592016713 N-terminal plug; other site 216592016714 ligand-binding site [chemical binding]; other site 216592016715 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 5.1e-16 216592016716 HMMPfam hit to PF00593, TonB dependent receptor, score 3.2e-34 216592016717 PS01156 TonB-dependent receptor proteins signature 2. 216592016718 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 216592016719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592016720 ATP binding site [chemical binding]; other site 216592016721 Mg2+ binding site [ion binding]; other site 216592016722 G-X-G motif; other site 216592016723 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216592016724 anchoring element; other site 216592016725 dimer interface [polypeptide binding]; other site 216592016726 ATP binding site [chemical binding]; other site 216592016727 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 216592016728 active site 216592016729 metal binding site [ion binding]; metal-binding site 216592016730 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216592016731 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 6.3e-34 216592016732 PS00177 DNA topoisomerase II signature. 216592016733 HMMPfam hit to PF00204, DNA gyrase B, score 1.2e-57 216592016734 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.5e-24 216592016735 esterase YqiA; Provisional; Region: PRK11071 216592016736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216592016737 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 7.7e-108 216592016738 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 216592016739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216592016740 active site 216592016741 metal binding site [ion binding]; metal-binding site 216592016742 hexamer interface [polypeptide binding]; other site 216592016743 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.1e-19 216592016744 putative dehydrogenase; Provisional; Region: PRK11039 216592016745 HMMPfam hit to PF06853, Protein of unknown function (DUF1249), score 2.3e-93 216592016746 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 216592016747 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216592016748 dimer interface [polypeptide binding]; other site 216592016749 ADP-ribose binding site [chemical binding]; other site 216592016750 active site 216592016751 nudix motif; other site 216592016752 metal binding site [ion binding]; metal-binding site 216592016753 HMMPfam hit to PF00293, NUDIX domain, score 8.1e-20 216592016754 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 216592016755 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.4e-45 216592016756 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.7e-56 216592016757 hypothetical protein; Provisional; Region: PRK11653 216592016758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592016759 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 216592016760 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 5.2e-277 216592016761 Present in Uropathogenic, absent in 0157, islet (arylsulfotransferase and Disulfide bond formation proteins, dsbl and dsbI) 216592016762 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 216592016763 1 probable transmembrane helix predicted for EC042_3329 by TMHMM2.0 at aa 7-29 216592016764 HMMPfam hit to PF05935, Arylsulfotransferase (ASST), score 0 216592016765 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 216592016766 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216592016767 catalytic residues [active] 216592016768 hinge region; other site 216592016769 alpha helical domain; other site 216592016770 1 probable transmembrane helix predicted for EC042_3330 by TMHMM2.0 at aa 7-29 216592016771 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.1e-06 216592016772 putative disulfide oxidoreductase; Provisional; Region: PRK04307 216592016773 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 0.00027 216592016774 4 probable transmembrane helices predicted for EC042_3331 by TMHMM2.0 at aa 26-48, 58-77, 82-104 and 196-218 216592016775 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 216592016776 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 216592016777 putative active site [active] 216592016778 metal binding site [ion binding]; metal-binding site 216592016779 HMMPfam hit to PF02900, Catalytic LigB subunit of aromatic ring-open, score 3.9e-98 216592016780 zinc transporter ZupT; Provisional; Region: PRK04201 216592016781 ZIP Zinc transporter; Region: Zip; pfam02535 216592016782 6 probable transmembrane helices predicted for EC042_3333 by TMHMM2.0 at aa 15-37, 46-68, 78-95, 183-205, 209-231 and 248-270 216592016783 HMMPfam hit to PF02535, ZIP Zinc transporter, score 8.5e-55 216592016784 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 216592016785 1 probable transmembrane helix predicted for EC042_3334 by TMHMM2.0 at aa 7-26 216592016786 Fimbrial operon 9. Present in Uropathogenic, absent in 0157, fimbrial usher genes 216592016787 putative fimbrial protein; Provisional; Region: PRK09733 216592016788 HMMPfam hit to PF00419, Fimbrial protein, score 1.6e-39 216592016789 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216592016790 PapC N-terminal domain; Region: PapC_N; pfam13954 216592016791 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592016792 PapC C-terminal domain; Region: PapC_C; pfam13953 216592016793 1 probable transmembrane helix predicted for EC042_3336 by TMHMM2.0 at aa 13-35 216592016794 HMMPfam hit to PF00577, Fimbrial Usher protein, score 2.3e-290 216592016795 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592016796 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 216592016797 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592016798 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592016799 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 7.9e-40 216592016800 PS00635 Gram-negative pili assembly chaperone signature. 216592016801 Fimbrial protein; Region: Fimbrial; pfam00419 216592016802 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 216592016803 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 216592016804 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate sy, score 1.7e-132 216592016805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 216592016806 HMMPfam hit to PF04380, Protein of unknown function (DUF526), score 6.7e-49 216592016807 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 216592016808 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 216592016809 HMMPfam hit to PF07290, Protein of unknown function (DUF1449), score 3.2e-151 216592016810 3 probable transmembrane helices predicted for EC042_3342 by TMHMM2.0 at aa 13-35, 63-85 and 97-119 216592016811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 216592016812 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 216592016813 2 probable transmembrane helices predicted for EC042_3343 by TMHMM2.0 at aa 11-33 and 46-68 216592016814 HMMPfam hit to PF01145, SPFH domain / Band, score 3.3e-34 216592016815 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 216592016816 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 216592016817 putative ribose interaction site [chemical binding]; other site 216592016818 putative ADP binding site [chemical binding]; other site 216592016819 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 216592016820 active site 216592016821 nucleotide binding site [chemical binding]; other site 216592016822 HIGH motif; other site 216592016823 KMSKS motif; other site 216592016824 HMMPfam hit to PF01467, Cytidylyltransferase, score 3.7e-23 216592016825 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 3.1e-62 216592016826 PS00583 pfkB family of carbohydrate kinases signature 1. 216592016827 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 216592016828 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216592016829 metal binding triad; other site 216592016830 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216592016831 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216592016832 metal binding triad; other site 216592016833 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216592016834 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 3.6e-137 216592016835 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 7.2e-133 216592016836 Uncharacterized conserved protein [Function unknown]; Region: COG3025 216592016837 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 216592016838 putative active site [active] 216592016839 putative metal binding residues [ion binding]; other site 216592016840 signature motif; other site 216592016841 putative triphosphate binding site [ion binding]; other site 216592016842 CHAD domain; Region: CHAD; pfam05235 216592016843 HMMPfam hit to PF05235, CHAD domain, score 7e-48 216592016844 HMMPfam hit to PF01928, CYTH domain, score 1.6e-65 216592016845 SH3 domain-containing protein; Provisional; Region: PRK10884 216592016846 Bacterial SH3 domain homologues; Region: SH3b; smart00287 216592016847 1 probable transmembrane helix predicted for EC042_3349 by TMHMM2.0 at aa 173-195 216592016848 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 216592016849 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216592016850 active site 216592016851 NTP binding site [chemical binding]; other site 216592016852 metal binding triad [ion binding]; metal-binding site 216592016853 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216592016854 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216592016855 Zn2+ binding site [ion binding]; other site 216592016856 Mg2+ binding site [ion binding]; other site 216592016857 HMMPfam hit to PF01743, Poly A polymerase family, score 2.7e-71 216592016858 HMMPfam hit to PF01966, HD domain, score 3.3e-20 216592016859 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 216592016860 7 probable transmembrane helices predicted for EC042_3351 by TMHMM2.0 at aa 7-29, 49-71, 91-110, 120-137, 188-210, 225-247 and 254-273 216592016861 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 9.3e-156 216592016862 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 216592016863 homooctamer interface [polypeptide binding]; other site 216592016864 active site 216592016865 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 1.4e-51 216592016866 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 216592016867 5 probable transmembrane helices predicted for EC042_3353 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158 216592016868 HMMPfam hit to PF02660, Domain of unknown function DUF, score 3.1e-108 216592016869 transcriptional activator TtdR; Provisional; Region: PRK09801 216592016870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592016871 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 216592016872 putative effector binding pocket; other site 216592016873 putative dimerization interface [polypeptide binding]; other site 216592016874 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-38 216592016875 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.8e-16 216592016876 PS00044 Bacterial regulatory proteins, lysR family signature. 216592016877 Predicted helix-turn-helix motif with score 1058.000, SD 2.79 at aa 21-42, sequence GSFSAAAATLGQTPAFVTKRIQ 216592016878 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 216592016879 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 4.6e-146 216592016880 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 216592016881 HMMPfam hit to PF05683, Fumarase C-terminus, score 4.7e-37 216592016882 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216592016883 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 216592016884 transmembrane helices; other site 216592016885 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 1.3e-286 216592016886 12 probable transmembrane helices predicted for EC042_3357 by TMHMM2.0 at aa 7-29, 33-50, 52-74, 94-116, 137-154, 197-219, 232-254, 306-328, 341-363, 378-400, 420-442 and 462-484 216592016887 UGMP family protein; Validated; Region: PRK09604 216592016888 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 216592016889 HMMPfam hit to PF00814, Glycoprotease family, score 6.7e-26 216592016890 PS01016 Glycoprotease family signature. 216592016891 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 216592016892 DNA primase; Validated; Region: dnaG; PRK05667 216592016893 CHC2 zinc finger; Region: zf-CHC2; pfam01807 216592016894 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 216592016895 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 216592016896 active site 216592016897 metal binding site [ion binding]; metal-binding site 216592016898 interdomain interaction site; other site 216592016899 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 216592016900 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 216592016901 HMMPfam hit to PF01807, CHC2 zinc finger, score 4.6e-66 216592016902 HMMPfam hit to PF01751, Toprim domain, score 1.7e-26 216592016903 1 probable transmembrane helix predicted for EC042_3360 by TMHMM2.0 at aa 21-43 216592016904 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 216592016905 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 216592016906 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216592016907 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 216592016908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592016909 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216592016910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592016911 DNA binding residues [nucleotide binding] 216592016912 HMMPfam hit to PF03979, Sigma-70 factor, region, score 1.8e-42 216592016913 HMMPfam hit to PF00140, Sigma-70 factor, region, score 2.4e-15 216592016914 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 6.4e-126 216592016915 HMMPfam hit to PF04542, Sigma-70 region, score 1.7e-28 216592016916 PS00715 Sigma-70 factors family signature 1. 216592016917 HMMPfam hit to PF04539, Sigma-70 region, score 2e-41 216592016918 HMMPfam hit to PF04545, Sigma-70, region, score 1.7e-22 216592016919 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 571-592, sequence HTLEEVGKQFDVTRERIRQIEA 216592016920 PS00716 Sigma-70 factors family signature 2. 216592016921 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 216592016922 active site 216592016923 SUMO-1 interface [polypeptide binding]; other site 216592016924 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 1.9e-27 216592016925 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 216592016926 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 216592016927 FAD binding pocket [chemical binding]; other site 216592016928 FAD binding motif [chemical binding]; other site 216592016929 phosphate binding motif [ion binding]; other site 216592016930 NAD binding pocket [chemical binding]; other site 216592016931 HMMPfam hit to PF04954, Siderophore-interacting protein, score 3e-139 216592016932 Predicted transcriptional regulators [Transcription]; Region: COG1695 216592016933 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216592016934 HMMPfam hit to PF03551, Transcriptional regulator PadR-like family, score 2.5e-18 216592016935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592016936 PAS fold; Region: PAS_3; pfam08447 216592016937 putative active site [active] 216592016938 heme pocket [chemical binding]; other site 216592016939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 216592016940 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216592016941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216592016942 dimer interface [polypeptide binding]; other site 216592016943 putative CheW interface [polypeptide binding]; other site 216592016944 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.4e-61 216592016945 HMMPfam hit to PF00672, HAMP domain, score 2e-05 216592016946 1 probable transmembrane helix predicted for EC042_3365 by TMHMM2.0 at aa 172-194 216592016947 HMMPfam hit to PF00785, PAC motif, score 7.6e-07 216592016948 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 216592016949 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592016950 inhibitor-cofactor binding pocket; inhibition site 216592016951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592016952 catalytic residue [active] 216592016953 HMMPfam hit to PF00202, Aminotransferase class-III, score 3.1e-204 216592016954 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592016955 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 216592016956 dimer interface [polypeptide binding]; other site 216592016957 putative tRNA-binding site [nucleotide binding]; other site 216592016958 HMMPfam hit to PF01588, Putative tRNA binding domain, score 1.6e-46 216592016959 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 216592016960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592016961 DNA binding site [nucleotide binding] 216592016962 domain linker motif; other site 216592016963 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 216592016964 putative dimerization interface [polypeptide binding]; other site 216592016965 putative ligand binding site [chemical binding]; other site 216592016966 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.2e-11 216592016967 Predicted helix-turn-helix motif with score 1898.000, SD 5.65 at aa 2-23, sequence ATLKDIAIEAGVSLATVSRVLN 216592016968 PS00356 Bacterial regulatory proteins, lacI family signature. 216592016969 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 6.4e-93 216592016970 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 216592016971 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216592016972 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216592016973 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216592016974 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 216592016975 HMMPfam hit to PF02837, Glycosyl hydrolases family 2, sugar b, score 4.2e-84 216592016976 HMMPfam hit to PF00703, Glycosyl hydrolases family 2, immunog, score 1.4e-50 216592016977 HMMPfam hit to PF02836, Glycosyl hydrolases family 2, TIM bar, score 2.4e-176 216592016978 PS00719 Glycosyl hydrolases family 2 signature 1. 216592016979 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 216592016980 HMMPfam hit to PF02929, Beta galactosidase small chain, N ter, score 1.1e-74 216592016981 HMMPfam hit to PF02930, Beta galactosidase small chain, C ter, score 7.9e-51 216592016982 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 216592016983 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 8e-59 216592016984 inner membrane transporter YjeM; Provisional; Region: PRK15238 216592016985 HMMPfam hit to PF00324, Amino acid permease, score 9e-05 216592016986 12 probable transmembrane helices predicted for EC042_3371 by TMHMM2.0 at aa 12-29, 42-64, 93-115, 120-142, 155-177, 197-219, 232-254, 282-304, 332-354, 364-386, 407-426 and 430-452 216592016987 PS00589 PTS HPR component serine phosphorylation site signature. 216592016988 alpha-glucosidase; Provisional; Region: PRK10137 216592016989 Protein of unknown function, DUF608; Region: DUF608; pfam04685 216592016990 Trehalase; Region: Trehalase; cl17346 216592016991 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216592016992 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 216592016993 active site 216592016994 FMN binding site [chemical binding]; other site 216592016995 2,4-decadienoyl-CoA binding site; other site 216592016996 catalytic residue [active] 216592016997 4Fe-4S cluster binding site [ion binding]; other site 216592016998 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 216592016999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592017000 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 5e-158 216592017001 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 3.2e-08 216592017002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592017003 non-specific DNA binding site [nucleotide binding]; other site 216592017004 salt bridge; other site 216592017005 sequence-specific DNA binding site [nucleotide binding]; other site 216592017006 HMMPfam hit to PF01381, Helix-turn-helix, score 4.7e-09 216592017007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 216592017008 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 216592017009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592017010 S-adenosylmethionine binding site [chemical binding]; other site 216592017011 HMMPfam hit to PF05175, Methyltransferase small domain, score 3.4e-19 216592017012 PS00092 N-6 Adenine-specific DNA methylases signature. 216592017013 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 216592017014 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216592017015 putative active site [active] 216592017016 1 probable transmembrane helix predicted for EC042_3379 by TMHMM2.0 at aa 21-38 216592017017 HMMPfam hit to PF02698, DUF218 domain, score 4.5e-43 216592017018 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216592017019 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216592017020 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 1.5e-47 216592017021 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 0.0015 216592017022 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 216592017023 9 probable transmembrane helices predicted for EC042_3381 by TMHMM2.0 at aa 10-29, 42-64, 88-110, 115-137, 142-161, 198-220, 235-257, 264-286 and 290-312 216592017024 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 1.8e-104 216592017025 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017026 serine/threonine transporter SstT; Provisional; Region: PRK13628 216592017027 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216592017028 8 probable transmembrane helices predicted for EC042_3383 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 141-163, 183-205, 215-237, 292-314 and 329-351 216592017029 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2e-177 216592017030 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 216592017031 4 probable transmembrane helices predicted for EC042_3384 by TMHMM2.0 at aa 5-22, 37-59, 72-89 and 134-156 216592017032 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 216592017033 galactarate dehydratase; Region: galactar-dH20; TIGR03248 216592017034 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 216592017035 HMMPfam hit to PF04295, D-galactarate dehydratase / Altronate hydrol, score 2.6e-271 216592017036 HMMPfam hit to PF04292, D-galactarate dehydratase / Altronate hydrol, score 4.6e-54 216592017037 Glucuronate isomerase; Region: UxaC; pfam02614 216592017038 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 216592017039 HMMPfam hit to PF02614, Glucuronate isomerase, score 0 216592017040 D-galactonate transporter; Region: 2A0114; TIGR00893 216592017041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592017042 putative substrate translocation pore; other site 216592017043 11 probable transmembrane helices predicted for EC042_3387 by TMHMM2.0 at aa 47-66, 87-109, 119-141, 176-198, 203-225, 272-294, 309-331, 344-363, 368-390, 403-425 and 430-452 216592017044 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-69 216592017045 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 216592017046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592017047 DNA-binding site [nucleotide binding]; DNA binding site 216592017048 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592017049 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 2.2e-28 216592017050 PS00043 Bacterial regulatory proteins, gntR family signature. 216592017051 HMMPfam hit to PF07729, FCD domain, score 9.8e-30 216592017052 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216592017053 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216592017054 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216592017055 6 probable transmembrane helices predicted for EC042_3389 by TMHMM2.0 at aa 19-38, 42-64, 71-93, 126-148, 153-175 and 190-212 216592017056 HMMPfam hit to PF00597, DedA family, score 2.5e-71 216592017057 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 216592017058 1 probable transmembrane helix predicted for EC042_3390 by TMHMM2.0 at aa 12-31 216592017059 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 216592017060 HMMPfam hit to PF06476, Protein of unknown function (DUF1090), score 2.3e-60 216592017061 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 216592017062 HMMPfam hit to PF05957, Bacterial protein of unknown function (DUF88, score 1.2e-52 216592017063 1 probable transmembrane helix predicted for EC042_3392 by TMHMM2.0 at aa 81-98 216592017064 Predicted membrane protein [Function unknown]; Region: COG5393 216592017065 2 probable transmembrane helices predicted for EC042_3393 by TMHMM2.0 at aa 73-95 and 105-127 216592017066 YqjK-like protein; Region: YqjK; pfam13997 216592017067 1 probable transmembrane helix predicted for EC042_3394 by TMHMM2.0 at aa 46-65 216592017068 Predicted membrane protein [Function unknown]; Region: COG2259 216592017069 HMMPfam hit to PF07681, DoxX, score 4e-38 216592017070 4 probable transmembrane helices predicted for EC042_3395 by TMHMM2.0 at aa 39-61, 76-98, 103-120 and 135-152 216592017071 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 216592017072 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 216592017073 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 216592017074 putative dimer interface [polypeptide binding]; other site 216592017075 N-terminal domain interface [polypeptide binding]; other site 216592017076 putative substrate binding pocket (H-site) [chemical binding]; other site 216592017077 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 0.00028 216592017078 Predicted membrane protein [Function unknown]; Region: COG3152 216592017079 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 6.8e-52 216592017080 3 probable transmembrane helices predicted for EC042_3397 by TMHMM2.0 at aa 23-40, 53-70 and 83-105 216592017081 Protein of unknown function (DUF805); Region: DUF805; pfam05656 216592017082 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 2e-47 216592017083 3 probable transmembrane helices predicted for EC042_3398 by TMHMM2.0 at aa 23-45, 49-71 and 78-100 216592017084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592017085 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 216592017086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592017087 dimerization interface [polypeptide binding]; other site 216592017088 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-13 216592017089 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.9e-15 216592017090 PS00044 Bacterial regulatory proteins, lysR family signature. 216592017091 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 22-43, sequence GSFAAAADELGRVPSALSYTMQ 216592017092 Pirin-related protein [General function prediction only]; Region: COG1741 216592017093 Pirin; Region: Pirin; pfam02678 216592017094 HMMPfam hit to PF02678, Pirin, score 9.7e-40 216592017095 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 216592017096 HMMPfam hit to PF06354, Protein of unknown function (DUF1063), score 2.3e-302 216592017097 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216592017098 serine transporter; Region: stp; TIGR00814 216592017099 11 probable transmembrane helices predicted for EC042_3403 by TMHMM2.0 at aa 38-60, 65-87, 112-134, 149-171, 184-206, 221-243, 264-286, 318-340, 363-385, 389-411 and 423-442 216592017100 L-serine dehydratase TdcG; Provisional; Region: PRK15040 216592017101 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216592017102 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216592017103 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 5.9e-194 216592017104 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 2.9e-105 216592017105 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017106 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216592017107 homotrimer interaction site [polypeptide binding]; other site 216592017108 putative active site [active] 216592017109 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.8e-65 216592017110 PS01094 Uncharacterized protein family UPF0076 signature. 216592017111 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 216592017112 Pyruvate formate lyase 1; Region: PFL1; cd01678 216592017113 coenzyme A binding site [chemical binding]; other site 216592017114 active site 216592017115 catalytic residues [active] 216592017116 glycine loop; other site 216592017117 HMMPfam hit to PF01228, Glycine radical, score 7.2e-69 216592017118 PS00850 Glycine radical signature. 216592017119 HMMPfam hit to PF02901, Pyruvate formate lyase, score 0 216592017120 propionate/acetate kinase; Provisional; Region: PRK12379 216592017121 Acetokinase family; Region: Acetate_kinase; cl17229 216592017122 HMMPfam hit to PF00871, Acetokinase family, score 8.4e-245 216592017123 PS00307 Legume lectins beta-chain signature. 216592017124 PS01076 Acetate and butyrate kinases family signature 2. 216592017125 PS01075 Acetate and butyrate kinases family signature 1. 216592017126 threonine/serine transporter TdcC; Provisional; Region: PRK13629 216592017127 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216592017128 11 probable transmembrane helices predicted for EC042_3408 by TMHMM2.0 at aa 23-40, 44-66, 97-119, 134-156, 163-185, 212-234, 255-277, 311-333, 358-380, 390-409 and 422-440 216592017129 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 216592017130 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216592017131 tetramer interface [polypeptide binding]; other site 216592017132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592017133 catalytic residue [active] 216592017134 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5e-95 216592017135 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216592017136 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 216592017137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592017138 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 216592017139 putative substrate binding pocket [chemical binding]; other site 216592017140 putative dimerization interface [polypeptide binding]; other site 216592017141 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.9e-33 216592017142 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3e-21 216592017143 PS00044 Bacterial regulatory proteins, lysR family signature. 216592017144 Predicted helix-turn-helix motif with score 2018.000, SD 6.06 at aa 22-43, sequence GSIGSAAKELGLTQPAVSKIIN 216592017145 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 216592017146 PS00070 Aldehyde dehydrogenases cysteine active site. 216592017147 hypothetical protein; Provisional; Region: PRK09716 216592017148 glycerate kinase I; Provisional; Region: PRK10342 216592017149 HMMPfam hit to PF02595, Glycerate kinase family, score 6.4e-292 216592017150 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017151 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 216592017152 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216592017153 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 3.8e-05 216592017154 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 216592017155 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 216592017156 HMMPfam hit to PF03328, HpcH/HpaI aldolase/citrate lyase family, score 2.2e-109 216592017157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592017158 D-galactonate transporter; Region: 2A0114; TIGR00893 216592017159 putative substrate translocation pore; other site 216592017160 HMMPfam hit to PF00083, Sugar (and other) transporter, score 0.00012 216592017161 11 probable transmembrane helices predicted for EC042_3417 by TMHMM2.0 at aa 15-32, 53-75, 90-112, 151-173, 177-199, 251-273, 288-310, 317-339, 349-371, 380-402 and 412-434 216592017162 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-58 216592017164 PS00430 TonB-dependent receptor proteins signature 1. 216592017165 HMMPfam hit to PF04292, D-galactarate dehydratase / Altronate hydrol, score 9.2e-34 216592017166 HMMPfam hit to PF04295, D-galactarate dehydratase / Altronate hydrol, score 3.3e-86 216592017167 putative regulator PrlF; Provisional; Region: PRK09974 216592017168 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 216592017169 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 216592017170 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 216592017171 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216592017172 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592017173 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 8.8e-124 216592017174 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592017175 PS00894 Bacterial regulatory proteins, deoR family signature. 216592017176 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 216592017177 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 216592017178 active site 216592017179 phosphorylation site [posttranslational modification] 216592017180 HMMPfam hit to PF03830, PTS system sorbose subfamily IIB componen, score 1.9e-91 216592017181 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 216592017182 HMMPfam hit to PF03609, PTS system sorbose-specific iic component, score 1.3e-124 216592017183 6 probable transmembrane helices predicted for EC042_3425 by TMHMM2.0 at aa 5-27, 34-56, 98-120, 141-163, 178-197 and 209-231 216592017184 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 216592017185 HMMPfam hit to PF03613, PTS system mannose/fructose/sorbose family I, score 1.8e-149 216592017186 4 probable transmembrane helices predicted for EC042_3426 by TMHMM2.0 at aa 91-113, 163-185, 206-228 and 251-268 216592017187 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 216592017188 active pocket/dimerization site; other site 216592017189 active site 216592017190 phosphorylation site [posttranslational modification] 216592017191 HMMPfam hit to PF03610, PTS system fructose IIA component, score 1e-45 216592017192 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 216592017193 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 216592017194 active site 216592017195 dimer interface [polypeptide binding]; other site 216592017196 HMMPfam hit to PF01979, Amidohydrolase family, score 5.5e-15 216592017197 1 probable transmembrane helix predicted for EC042_3429 by TMHMM2.0 at aa 42-64 216592017198 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 216592017199 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216592017200 dimer interface [polypeptide binding]; other site 216592017201 active site 216592017202 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 216592017203 putative active site [active] 216592017204 HMMPfam hit to PF01380, SIS domain, score 9.7e-21 216592017205 HMMPfam hit to PF01380, SIS domain, score 3.2e-22 216592017206 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 216592017207 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216592017208 active site 216592017209 intersubunit interface [polypeptide binding]; other site 216592017210 zinc binding site [ion binding]; other site 216592017211 Na+ binding site [ion binding]; other site 216592017212 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 3.2e-160 216592017213 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 216592017214 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 216592017215 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 216592017216 active site 216592017217 phosphorylation site [posttranslational modification] 216592017218 HMMPfam hit to PF03830, PTS system sorbose subfamily IIB componen, score 3e-85 216592017219 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 216592017220 HMMPfam hit to PF03609, PTS system sorbose-specific iic component, score 2.9e-112 216592017221 6 probable transmembrane helices predicted for EC042_3433 by TMHMM2.0 at aa 4-21, 28-50, 96-118, 139-161, 176-198 and 210-232 216592017222 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 216592017223 HMMPfam hit to PF03613, PTS system mannose/fructose/sorbose family I, score 1.9e-151 216592017224 5 probable transmembrane helices predicted for EC042_3434 by TMHMM2.0 at aa 121-143, 158-180, 200-222, 242-259 and 266-285 216592017225 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 216592017226 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 216592017227 active site 216592017228 trimer interface [polypeptide binding]; other site 216592017229 allosteric site; other site 216592017230 active site lid [active] 216592017231 hexamer (dimer of trimers) interface [polypeptide binding]; other site 216592017232 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 3e-09 216592017233 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 216592017234 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 216592017235 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 216592017236 putative SAM binding site [chemical binding]; other site 216592017237 putative homodimer interface [polypeptide binding]; other site 216592017238 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 1e-71 216592017239 PS01296 Uncharacterized protein family UPF0011 signature. 216592017240 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216592017241 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 216592017242 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 216592017243 putative ligand binding site [chemical binding]; other site 216592017244 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017245 HMMPfam hit to PF04348, LppC putative lipoprotein, score 1.2e-113 216592017246 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017247 TIGR00252 family protein; Region: TIGR00252 216592017248 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 216592017249 dimer interface [polypeptide binding]; other site 216592017250 active site 216592017251 HMMPfam hit to PF01380, SIS domain, score 9e-27 216592017252 outer membrane lipoprotein; Provisional; Region: PRK11023 216592017253 BON domain; Region: BON; pfam04972 216592017254 BON domain; Region: BON; pfam04972 216592017255 1 probable transmembrane helix predicted for EC042_3439 by TMHMM2.0 at aa 7-29 216592017256 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017257 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 7.4e-13 216592017258 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 2.5e-14 216592017259 Predicted permease; Region: DUF318; pfam03773 216592017260 9 probable transmembrane helices predicted for EC042_3440 by TMHMM2.0 at aa 15-32, 74-96, 111-133, 146-168, 172-191, 226-248, 263-285, 292-314 and 324-345 216592017261 HMMPfam hit to PF03773, Predicted permease, score 5e-120 216592017262 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 216592017263 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216592017264 NAD binding site [chemical binding]; other site 216592017265 active site 216592017266 intracellular protease, PfpI family; Region: PfpI; TIGR01382 216592017267 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 216592017268 proposed catalytic triad [active] 216592017269 conserved cys residue [active] 216592017270 HMMPfam hit to PF01965, DJ-1/PfpI family, score 3.8e-56 216592017271 1 probable transmembrane helix predicted for EC042_3443 by TMHMM2.0 at aa 20-42 216592017272 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 216592017273 GIY-YIG motif/motif A; other site 216592017274 putative active site [active] 216592017275 putative metal binding site [ion binding]; other site 216592017276 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 6.4e-16 216592017277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216592017278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592017279 Coenzyme A binding pocket [chemical binding]; other site 216592017280 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.6e-15 216592017281 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 216592017282 HMMPfam hit to PF02036, SCP-2 sterol transfer family, score 4.4e-33 216592017283 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 216592017284 Peptidase family U32; Region: Peptidase_U32; pfam01136 216592017285 HMMPfam hit to PF01136, Peptidase family U32, score 1.9e-122 216592017286 PS01276 Peptidase family U32 signature. 216592017287 putative protease; Provisional; Region: PRK15447 216592017288 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 216592017289 HMMPfam hit to PF01136, Peptidase family U32, score 6.5e-08 216592017290 hypothetical protein; Provisional; Region: PRK10508 216592017291 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216592017292 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 3.5e-15 216592017293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 216592017294 HMMPfam hit to PF06104, Bacterial protein of unknown function (DUF94, score 4.2e-152 216592017295 1 probable transmembrane helix predicted for EC042_3450 by TMHMM2.0 at aa 5-24 216592017296 tryptophan permease; Provisional; Region: PRK10483 216592017297 aromatic amino acid transport protein; Region: araaP; TIGR00837 216592017298 11 probable transmembrane helices predicted for EC042_3452 by TMHMM2.0 at aa 13-35, 39-61, 87-109, 124-146, 153-175, 190-212, 225-247, 284-306, 318-340, 345-367 and 388-410 216592017299 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 3.2e-239 216592017300 PS00594 Aromatic amino acids permeases signature. 216592017301 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 216592017302 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216592017303 ATP binding site [chemical binding]; other site 216592017304 Mg++ binding site [ion binding]; other site 216592017305 motif III; other site 216592017306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592017307 nucleotide binding region [chemical binding]; other site 216592017308 ATP-binding site [chemical binding]; other site 216592017309 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 216592017310 putative RNA binding site [nucleotide binding]; other site 216592017311 HMMPfam hit to PF03880, DbpA RNA binding domain, score 4.9e-42 216592017312 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 8e-34 216592017313 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.5e-74 216592017314 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592017315 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017316 lipoprotein NlpI; Provisional; Region: PRK11189 216592017317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592017318 binding surface 216592017319 TPR motif; other site 216592017320 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.13 216592017321 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.1 216592017322 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 9.2e-06 216592017323 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.00012 216592017324 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017325 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 216592017326 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 216592017327 RNase E interface [polypeptide binding]; other site 216592017328 trimer interface [polypeptide binding]; other site 216592017329 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 216592017330 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 216592017331 RNase E interface [polypeptide binding]; other site 216592017332 trimer interface [polypeptide binding]; other site 216592017333 active site 216592017334 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 216592017335 putative nucleic acid binding region [nucleotide binding]; other site 216592017336 G-X-X-G motif; other site 216592017337 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 216592017338 RNA binding site [nucleotide binding]; other site 216592017339 domain interface; other site 216592017340 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.1e-27 216592017341 HMMPfam hit to PF00013, KH domain, score 2.3e-16 216592017342 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 1.1e-21 216592017343 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 2.3e-55 216592017344 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 7.2e-39 216592017345 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 5.2e-19 216592017346 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 3e-44 216592017347 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 216592017348 16S/18S rRNA binding site [nucleotide binding]; other site 216592017349 S13e-L30e interaction site [polypeptide binding]; other site 216592017350 25S rRNA binding site [nucleotide binding]; other site 216592017351 HMMPfam hit to PF00312, Ribosomal protein S15, score 5.3e-50 216592017352 PS00362 Ribosomal protein S15 signature. 216592017353 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 216592017354 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 216592017355 RNA binding site [nucleotide binding]; other site 216592017356 active site 216592017357 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 216592017358 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 1e-92 216592017359 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 216592017360 HMMPfam hit to PF02033, Ribosome-binding factor A, score 2.4e-64 216592017361 PS01319 Ribosome-binding factor A signature. 216592017362 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216592017363 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 216592017364 translation initiation factor IF-2; Region: IF-2; TIGR00487 216592017365 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216592017366 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 216592017367 G1 box; other site 216592017368 putative GEF interaction site [polypeptide binding]; other site 216592017369 GTP/Mg2+ binding site [chemical binding]; other site 216592017370 Switch I region; other site 216592017371 G2 box; other site 216592017372 G3 box; other site 216592017373 Switch II region; other site 216592017374 G4 box; other site 216592017375 G5 box; other site 216592017376 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 216592017377 Translation-initiation factor 2; Region: IF-2; pfam11987 216592017378 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 216592017379 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.4e-10 216592017380 PS01176 Initiation factor 2 signature. 216592017381 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.9e-13 216592017382 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.4e-56 216592017383 HMMPfam hit to PF01926, GTPase of unknown function, score 2.5e-07 216592017384 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017385 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 3.3e-21 216592017386 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.4e-09 216592017387 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 216592017388 NusA N-terminal domain; Region: NusA_N; pfam08529 216592017389 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 216592017390 RNA binding site [nucleotide binding]; other site 216592017391 homodimer interface [polypeptide binding]; other site 216592017392 NusA-like KH domain; Region: KH_5; pfam13184 216592017393 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216592017394 G-X-X-G motif; other site 216592017395 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 216592017396 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 216592017397 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.3e-12 216592017398 ribosome maturation protein RimP; Reviewed; Region: PRK00092 216592017399 hypothetical protein; Provisional; Region: PRK14641 216592017400 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 216592017401 putative oligomer interface [polypeptide binding]; other site 216592017402 putative RNA binding site [nucleotide binding]; other site 216592017403 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 2.7e-73 216592017404 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 216592017405 ANP binding site [chemical binding]; other site 216592017406 Substrate Binding Site II [chemical binding]; other site 216592017407 Substrate Binding Site I [chemical binding]; other site 216592017408 HMMPfam hit to PF00764, Arginosuccinate synthase, score 5e-222 216592017409 PS00564 Argininosuccinate synthase signature 1. 216592017410 PS00565 Argininosuccinate synthase signature 2. 216592017411 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 216592017412 Sulfatase; Region: Sulfatase; pfam00884 216592017413 HMMPfam hit to PF00884, Sulfatase, score 8.7e-97 216592017414 5 probable transmembrane helices predicted for EC042_3464 by TMHMM2.0 at aa 21-40, 50-72, 85-107, 117-139 and 152-171 216592017415 Preprotein translocase SecG subunit; Region: SecG; pfam03840 216592017416 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 5.9e-35 216592017417 2 probable transmembrane helices predicted for EC042_3466 by TMHMM2.0 at aa 7-24 and 53-75 216592017418 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 216592017419 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 216592017420 active site 216592017421 substrate binding site [chemical binding]; other site 216592017422 metal binding site [ion binding]; metal-binding site 216592017423 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 8.4e-21 216592017424 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 2.9e-43 216592017425 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 1.8e-49 216592017426 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 8.4e-61 216592017427 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216592017428 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216592017429 dihydropteroate synthase; Region: DHPS; TIGR01496 216592017430 substrate binding pocket [chemical binding]; other site 216592017431 dimer interface [polypeptide binding]; other site 216592017432 inhibitor binding site; inhibition site 216592017433 HMMPfam hit to PF00809, Pterin binding enzyme, score 8.4e-112 216592017434 PS00793 Dihydropteroate synthase signature 2. 216592017435 PS00792 Dihydropteroate synthase signature 1. 216592017436 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 216592017437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592017438 Walker A motif; other site 216592017439 ATP binding site [chemical binding]; other site 216592017440 Walker B motif; other site 216592017441 arginine finger; other site 216592017442 Peptidase family M41; Region: Peptidase_M41; pfam01434 216592017443 HMMPfam hit to PF01434, Peptidase family M41, score 3.6e-131 216592017444 HMMPfam hit to PF00004, ATPase family associated with various c, score 1.4e-97 216592017445 PS00674 AAA-protein family signature. 216592017446 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017447 HMMPfam hit to PF06480, FtsH Extracellular, score 1.1e-49 216592017448 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017449 2 probable transmembrane helices predicted for EC042_3469 by TMHMM2.0 at aa 7-26 and 100-122 216592017450 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 216592017451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592017452 S-adenosylmethionine binding site [chemical binding]; other site 216592017453 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 7.5e-79 216592017454 RNA-binding protein YhbY; Provisional; Region: PRK10343 216592017455 HMMPfam hit to PF01985, CRS1 / YhbY domain, score 4.5e-38 216592017456 PS01301 Uncharacterized protein family UPF0044 signature. 216592017457 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 216592017458 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 216592017459 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216592017460 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 4.2e-48 216592017461 PS00830 Prokaryotic transcription elongation factors signature 2. 216592017462 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 3.6e-48 216592017463 PS00829 Prokaryotic transcription elongation factors signature 1. 216592017464 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 216592017465 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 216592017466 HMMPfam hit to PF02113, D-Ala-D-Ala carboxypeptidase 3 (S13) fa, score 2.3e-220 216592017467 GTPase CgtA; Reviewed; Region: obgE; PRK12298 216592017468 GTP1/OBG; Region: GTP1_OBG; pfam01018 216592017469 Obg GTPase; Region: Obg; cd01898 216592017470 G1 box; other site 216592017471 GTP/Mg2+ binding site [chemical binding]; other site 216592017472 Switch I region; other site 216592017473 G2 box; other site 216592017474 G3 box; other site 216592017475 Switch II region; other site 216592017476 G4 box; other site 216592017477 G5 box; other site 216592017478 HMMPfam hit to PF01926, GTPase of unknown function, score 3e-38 216592017479 PS00905 GTP1/OBG family signature. 216592017480 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017481 HMMPfam hit to PF01018, GTP1/OBG, score 4.2e-107 216592017482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216592017483 EamA-like transporter family; Region: EamA; pfam00892 216592017484 EamA-like transporter family; Region: EamA; pfam00892 216592017485 10 probable transmembrane helices predicted for EC042_3475 by TMHMM2.0 at aa 7-26, 36-58, 71-93, 103-120, 129-151, 155-177, 190-212, 217-239, 246-268 and 278-300 216592017486 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.8e-15 216592017487 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.9e-30 216592017488 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216592017489 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216592017490 substrate binding pocket [chemical binding]; other site 216592017491 chain length determination region; other site 216592017492 substrate-Mg2+ binding site; other site 216592017493 catalytic residues [active] 216592017494 aspartate-rich region 1; other site 216592017495 active site lid residues [active] 216592017496 aspartate-rich region 2; other site 216592017497 HMMPfam hit to PF00348, Polyprenyl synthetase, score 4.4e-131 216592017498 PS00723 Polyprenyl synthetases signature 1. 216592017499 PS00444 Polyprenyl synthetases signature 2. 216592017500 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 216592017501 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 216592017502 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 216592017503 hinge; other site 216592017504 active site 216592017505 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 2.8e-188 216592017506 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 216592017507 HMMPfam hit to PF01722, BolA-like protein, score 2.4e-39 216592017508 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216592017509 anti sigma factor interaction site; other site 216592017510 regulatory phosphorylation site [posttranslational modification]; other site 216592017511 HMMPfam hit to PF01740, STAS domain, score 0.04 216592017512 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 216592017513 HMMPfam hit to PF05494, Toluene tolerance, Ttg2, score 7.8e-97 216592017514 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216592017515 mce related protein; Region: MCE; pfam02470 216592017516 HMMPfam hit to PF02470, mce related protein, score 2.7e-58 216592017517 1 probable transmembrane helix predicted for EC042_3483 by TMHMM2.0 at aa 7-26 216592017518 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216592017519 conserved hypothetical integral membrane protein; Region: TIGR00056 216592017520 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 1.1e-129 216592017521 5 probable transmembrane helices predicted for EC042_3484 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258 216592017522 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 216592017523 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 216592017524 Walker A/P-loop; other site 216592017525 ATP binding site [chemical binding]; other site 216592017526 Q-loop/lid; other site 216592017527 ABC transporter signature motif; other site 216592017528 Walker B; other site 216592017529 D-loop; other site 216592017530 H-loop/switch region; other site 216592017531 HMMPfam hit to PF00005, ABC transporter, score 1.5e-53 216592017532 PS00211 ABC transporters family signature. 216592017533 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017534 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 216592017535 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216592017536 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216592017537 9 probable transmembrane helices predicted for EC042_3486 by TMHMM2.0 at aa 7-29, 39-61, 68-90, 129-146, 172-194, 204-226, 239-261, 276-293 and 300-322 216592017538 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 3.8e-44 216592017539 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 5.4e-38 216592017540 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 216592017541 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 216592017542 putative active site [active] 216592017543 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216592017544 HMMPfam hit to PF01380, SIS domain, score 4.5e-38 216592017545 HMMPfam hit to PF00571, CBS domain, score 6e-07 216592017546 HMMPfam hit to PF00571, CBS domain, score 3.2e-10 216592017547 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 216592017548 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 216592017549 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 216592017550 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 216592017551 1 probable transmembrane helix predicted for EC042_3489 by TMHMM2.0 at aa 7-25 216592017552 HMMPfam hit to PF06835, Protein of unknown function (DUF1239), score 5.1e-82 216592017553 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 216592017554 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 216592017555 HMMPfam hit to PF03968, OstA-like protein, score 7.1e-78 216592017556 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 216592017557 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 216592017558 Walker A/P-loop; other site 216592017559 ATP binding site [chemical binding]; other site 216592017560 Q-loop/lid; other site 216592017561 ABC transporter signature motif; other site 216592017562 Walker B; other site 216592017563 D-loop; other site 216592017564 H-loop/switch region; other site 216592017565 HMMPfam hit to PF00005, ABC transporter, score 1.3e-61 216592017566 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017567 PS00211 ABC transporters family signature. 216592017568 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 216592017569 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 216592017570 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 216592017571 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 216592017572 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 5.9e-20 216592017573 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 1e-120 216592017574 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 9.6e-108 216592017575 PS00717 Sigma-54 factors family signature 1. 216592017576 Predicted helix-turn-helix motif with score 1756.000, SD 5.17 at aa 365-386, sequence MVLADIAQAVEMHESTISRVTT 216592017577 PS00718 Sigma-54 factors family signature 2. 216592017578 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216592017579 30S subunit binding site; other site 216592017580 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 1.1e-53 216592017581 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592017582 active site 216592017583 phosphorylation site [posttranslational modification] 216592017584 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 4.4e-68 216592017585 PS00372 PTS EIIA domains phosphorylation site signature 2. 216592017586 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 216592017587 HMMPfam hit to PF03668, P-loop ATPase protein family, score 7.8e-218 216592017588 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017589 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592017590 dimerization domain swap beta strand [polypeptide binding]; other site 216592017591 regulatory protein interface [polypeptide binding]; other site 216592017592 active site 216592017593 regulatory phosphorylation site [posttranslational modification]; other site 216592017594 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 4.4e-42 216592017595 PS00369 PTS HPR component histidine phosphorylation site signature. 216592017596 PS00589 PTS HPR component serine phosphorylation site signature. 216592017597 hypothetical protein; Provisional; Region: PRK10345 216592017598 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 216592017599 Transglycosylase; Region: Transgly; cl17702 216592017600 HMMPfam hit to PF00912, Transglycosylase, score 1.2e-75 216592017601 1 probable transmembrane helix predicted for EC042_3498 by TMHMM2.0 at aa 21-43 216592017602 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 216592017603 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 216592017604 conserved cys residue [active] 216592017605 HMMPfam hit to PF01965, DJ-1/PfpI family, score 1.2e-26 216592017606 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 216592017607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592017608 putative active site [active] 216592017609 heme pocket [chemical binding]; other site 216592017610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592017611 dimer interface [polypeptide binding]; other site 216592017612 phosphorylation site [posttranslational modification] 216592017613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592017614 ATP binding site [chemical binding]; other site 216592017615 Mg2+ binding site [ion binding]; other site 216592017616 G-X-G motif; other site 216592017617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592017618 active site 216592017619 phosphorylation site [posttranslational modification] 216592017620 intermolecular recognition site; other site 216592017621 dimerization interface [polypeptide binding]; other site 216592017622 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216592017623 putative binding surface; other site 216592017624 active site 216592017625 HMMPfam hit to PF01627, Hpt domain, score 1.8e-13 216592017626 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.5e-33 216592017627 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.8e-42 216592017628 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.5e-21 216592017629 HMMPfam hit to PF00989, PAS domain, score 2.4e-12 216592017630 2 probable transmembrane helices predicted for EC042_3500 by TMHMM2.0 at aa 20-42 and 55-77 216592017631 radical SAM protein, TIGR01212 family; Region: TIGR01212 216592017632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592017633 FeS/SAM binding site; other site 216592017634 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.3e-14 216592017635 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 216592017636 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 216592017637 active site 216592017638 dimer interface [polypeptide binding]; other site 216592017639 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 216592017640 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216592017641 active site 216592017642 FMN binding site [chemical binding]; other site 216592017643 substrate binding site [chemical binding]; other site 216592017644 3Fe-4S cluster binding site [ion binding]; other site 216592017645 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 216592017646 domain interface; other site 216592017647 HMMPfam hit to PF04897, Glutamate synthase amidotransferase d, score 3.1e-276 216592017648 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017649 HMMPfam hit to PF04898, Glutamate synthase central domain, score 7.9e-177 216592017650 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 3e-246 216592017651 HMMPfam hit to PF01493, GXGXG motif, score 3.3e-106 216592017652 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 216592017653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592017654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592017655 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 7.9e-37 216592017656 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 216592017657 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 216592017658 HMMPfam hit to PF06250, Protein of unknown function (DUF1016), score 2.6e-208 216592017659 Predicted helix-turn-helix motif with score 1039.000, SD 2.73 at aa 123-144, sequence CHLAQLAKSFPLPWSTYVRLLS 216592017660 Domain of unknown function (DUF386); Region: DUF386; cl01047 216592017661 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 6.6e-81 216592017662 N-acetylmannosamine kinase; Provisional; Region: PRK05082 216592017663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216592017664 nucleotide binding site [chemical binding]; other site 216592017665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216592017666 HMMPfam hit to PF00480, ROK family, score 1.4e-84 216592017667 PS01125 ROK family signature. 216592017668 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 216592017669 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 216592017670 putative active site cavity [active] 216592017671 HMMPfam hit to PF04131, Putative N-acetylmannosamine-6-phosphate epi, score 2.7e-142 216592017672 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017673 putative sialic acid transporter; Provisional; Region: PRK03893 216592017674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592017675 putative substrate translocation pore; other site 216592017676 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.9e-11 216592017677 12 probable transmembrane helices predicted for EC042_3508 by TMHMM2.0 at aa 21-43, 53-72, 92-114, 146-168, 170-189, 224-241, 248-267, 277-299, 316-338, 353-375, 404-426 and 431-453 216592017678 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.3e-34 216592017679 PS00146 Beta-lactamase class-A active site. 216592017680 N-acetylneuraminate lyase; Region: nanA; TIGR00683 216592017681 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 216592017682 inhibitor site; inhibition site 216592017683 active site 216592017684 dimer interface [polypeptide binding]; other site 216592017685 catalytic residue [active] 216592017686 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 1.5e-159 216592017687 PS00666 Dihydrodipicolinate synthetase signature 2. 216592017688 PS00665 Dihydrodipicolinate synthetase signature 1. 216592017689 transcriptional regulator NanR; Provisional; Region: PRK03837 216592017690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592017691 DNA-binding site [nucleotide binding]; DNA binding site 216592017692 FCD domain; Region: FCD; pfam07729 216592017693 HMMPfam hit to PF07729, FCD domain, score 1.8e-28 216592017694 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.7e-24 216592017695 PS00043 Bacterial regulatory proteins, gntR family signature. 216592017696 13 probable transmembrane helices predicted for EC042_3511 by TMHMM2.0 at aa 6-25, 32-54, 74-96, 116-138, 158-180, 199-221, 248-270, 277-296, 311-333, 354-376, 381-403, 415-437 and 441-460 216592017697 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 216592017698 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 216592017699 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1e-196 216592017700 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 216592017701 HMMPfam hit to PF04386, Stringent starvation protein B, score 7.9e-110 216592017702 stringent starvation protein A; Provisional; Region: sspA; PRK09481 216592017703 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 216592017704 C-terminal domain interface [polypeptide binding]; other site 216592017705 putative GSH binding site (G-site) [chemical binding]; other site 216592017706 dimer interface [polypeptide binding]; other site 216592017707 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 216592017708 dimer interface [polypeptide binding]; other site 216592017709 N-terminal domain interface [polypeptide binding]; other site 216592017710 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 3.3e-16 216592017711 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 3.1e-24 216592017712 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 216592017713 HMMPfam hit to PF00380, Ribosomal protein S9/S16, score 1.1e-73 216592017714 PS00360 Ribosomal protein S9 signature. 216592017715 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 216592017716 23S rRNA interface [nucleotide binding]; other site 216592017717 L3 interface [polypeptide binding]; other site 216592017718 HMMPfam hit to PF00572, Ribosomal protein L13, score 1.2e-88 216592017719 PS00783 Ribosomal protein L13 signature. 216592017720 Predicted ATPase [General function prediction only]; Region: COG1485 216592017721 HMMPfam hit to PF03969, AFG1-like ATPase, score 3.7e-240 216592017722 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 216592017724 hypothetical protein; Provisional; Region: PRK11677 216592017725 HMMPfam hit to PF06295, Protein of unknown function (DUF1043), score 1.6e-85 216592017726 1 probable transmembrane helix predicted for EC042_3518 by TMHMM2.0 at aa 5-24 216592017727 serine endoprotease; Provisional; Region: PRK10139 216592017728 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216592017729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592017730 protein binding site [polypeptide binding]; other site 216592017731 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592017732 1 probable transmembrane helix predicted for EC042_3519 by TMHMM2.0 at aa 21-43 216592017733 HMMPfam hit to PF00089, Trypsin, score 4.4e-23 216592017734 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.3e-21 216592017735 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.1e-15 216592017736 serine endoprotease; Provisional; Region: PRK10898 216592017737 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216592017738 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216592017739 1 probable transmembrane helix predicted for EC042_3520 by TMHMM2.0 at aa 5-27 216592017740 HMMPfam hit to PF00089, Trypsin, score 4.4e-27 216592017741 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 9.1e-14 216592017742 malate dehydrogenase; Provisional; Region: PRK05086 216592017743 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 216592017744 NAD binding site [chemical binding]; other site 216592017745 dimerization interface [polypeptide binding]; other site 216592017746 Substrate binding site [chemical binding]; other site 216592017747 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 9e-67 216592017748 PS00068 Malate dehydrogenase active site signature. 216592017749 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 8.9e-70 216592017750 arginine repressor; Provisional; Region: PRK05066 216592017751 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 216592017752 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 216592017753 HMMPfam hit to PF01316, Arginine repressor, DNA binding domai, score 1.5e-34 216592017754 HMMPfam hit to PF02863, Arginine repressor, C-terminal domain, score 9.9e-26 216592017755 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592017756 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 6.6e-56 216592017757 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 216592017758 RNAase interaction site [polypeptide binding]; other site 216592017759 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 216592017760 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592017761 10 probable transmembrane helices predicted for EC042_3525 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112, 119-136, 151-168, 366-388, 403-425, 432-449 and 481-503 216592017762 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 4.5e-51 216592017763 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 216592017764 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592017765 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592017766 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.1e-42 216592017767 1 probable transmembrane helix predicted for EC042_3526 by TMHMM2.0 at aa 13-32 216592017768 efflux system membrane protein; Provisional; Region: PRK11594 216592017769 2 probable transmembrane helices predicted for EC042_3527 by TMHMM2.0 at aa 29-51 and 66-85 216592017770 transcriptional regulator; Provisional; Region: PRK10632 216592017771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592017772 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216592017773 putative effector binding pocket; other site 216592017774 dimerization interface [polypeptide binding]; other site 216592017775 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-18 216592017776 Predicted helix-turn-helix motif with score 1455.000, SD 4.14 at aa 17-38, sequence GSFTAAARQLQMSVSSISQTVS 216592017777 PS00044 Bacterial regulatory proteins, lysR family signature. 216592017778 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.7e-44 216592017779 protease TldD; Provisional; Region: tldD; PRK10735 216592017780 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 2.8e-115 216592017781 hypothetical protein; Provisional; Region: PRK10899 216592017782 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216592017783 1 probable transmembrane helix predicted for EC042_3530 by TMHMM2.0 at aa 7-29 216592017784 ribonuclease G; Provisional; Region: PRK11712 216592017785 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216592017786 homodimer interface [polypeptide binding]; other site 216592017787 oligonucleotide binding site [chemical binding]; other site 216592017788 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.4e-19 216592017789 Maf-like protein; Region: Maf; pfam02545 216592017790 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216592017791 active site 216592017792 dimer interface [polypeptide binding]; other site 216592017793 HMMPfam hit to PF02545, Maf-like protein, score 2.3e-105 216592017794 rod shape-determining protein MreD; Provisional; Region: PRK11060 216592017795 HMMPfam hit to PF04093, rod shape-determining protein MreD, score 1.8e-64 216592017796 5 probable transmembrane helices predicted for EC042_3533 by TMHMM2.0 at aa 10-24, 31-53, 68-90, 97-119 and 134-151 216592017797 rod shape-determining protein MreC; Region: mreC; TIGR00219 216592017798 rod shape-determining protein MreC; Region: MreC; pfam04085 216592017799 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 1.2e-72 216592017800 1 probable transmembrane helix predicted for EC042_3534 by TMHMM2.0 at aa 13-35 216592017801 rod shape-determining protein MreB; Provisional; Region: PRK13927 216592017802 MreB and similar proteins; Region: MreB_like; cd10225 216592017803 nucleotide binding site [chemical binding]; other site 216592017804 Mg binding site [ion binding]; other site 216592017805 putative protofilament interaction site [polypeptide binding]; other site 216592017806 RodZ interaction site [polypeptide binding]; other site 216592017807 HMMPfam hit to PF06723, MreB/Mbl protein, score 7e-239 216592017808 regulatory protein CsrD; Provisional; Region: PRK11059 216592017809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592017810 metal binding site [ion binding]; metal-binding site 216592017811 active site 216592017812 I-site; other site 216592017813 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592017814 HMMPfam hit to PF00563, EAL domain, score 2.8e-59 216592017815 HMMPfam hit to PF00990, GGDEF domain, score 4.1e-41 216592017816 2 probable transmembrane helices predicted for EC042_3536 by TMHMM2.0 at aa 10-32 and 130-152 216592017817 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017818 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 216592017819 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 216592017820 NADP binding site [chemical binding]; other site 216592017821 dimer interface [polypeptide binding]; other site 216592017822 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 2.5e-40 216592017823 PS00213 Lipocalin signature. 216592017824 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 216592017825 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216592017826 carboxyltransferase (CT) interaction site; other site 216592017827 biotinylation site [posttranslational modification]; other site 216592017828 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 2.7e-35 216592017829 PS00188 Biotin-requiring enzymes attachment site. 216592017830 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216592017831 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216592017832 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216592017833 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216592017834 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 6e-58 216592017835 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 4.4e-127 216592017836 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216592017837 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216592017838 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 1.5e-66 216592017839 hypothetical protein; Provisional; Region: PRK10633 216592017840 HMMPfam hit to PF06196, Protein of unknown function (DUF997), score 2.6e-52 216592017841 2 probable transmembrane helices predicted for EC042_3540 by TMHMM2.0 at aa 13-35 and 45-64 216592017842 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 216592017843 Na binding site [ion binding]; other site 216592017844 13 probable transmembrane helices predicted for EC042_3541 by TMHMM2.0 at aa 4-26, 39-61, 74-96, 125-147, 162-184, 191-213, 235-257, 270-292, 321-343, 371-388, 393-415, 427-449 and 454-473 216592017845 HMMPfam hit to PF00474, Sodium:solute symporter family, score 4.5e-207 216592017846 PS00456 Sodium:solute symporter family signature 1. 216592017847 PS00457 Sodium:solute symporter family signature 2. 216592017848 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 216592017849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216592017850 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransferase (Prm, score 2.3e-178 216592017851 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 216592017852 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216592017853 FMN binding site [chemical binding]; other site 216592017854 active site 216592017855 catalytic residues [active] 216592017856 substrate binding site [chemical binding]; other site 216592017857 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.2e-161 216592017858 PS01136 Uncharacterized protein family UPF0034 signature. 216592017859 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 216592017860 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 216592017861 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 2.8e-15 216592017862 Predicted helix-turn-helix motif with score 1824.000, SD 5.40 at aa 72-93, sequence GNQTRAALMMGINRGTLRKKLK 216592017863 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216592017864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592017865 DNA methylase; Region: N6_N4_Mtase; pfam01555 216592017866 PS00092 N-6 Adenine-specific DNA methylases signature. 216592017867 HMMPfam hit to PF01555, DNA methylase, score 1.9e-64 216592017868 PS00294 Prenyl group binding site (CAAX box). 216592017869 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 216592017870 1 probable transmembrane helix predicted for EC042_3546 by TMHMM2.0 at aa 13-35 216592017871 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 216592017872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592017873 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 216592017874 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4e-20 216592017875 PS01081 Bacterial regulatory proteins, tetR family signature. 216592017876 Predicted helix-turn-helix motif with score 2001.000, SD 6.00 at aa 32-53, sequence TTLNDIADAANVTRGAIYWHFE 216592017877 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 216592017878 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592017879 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592017880 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017881 HMMPfam hit to PF00529, HlyD family secretion protein, score 3e-95 216592017882 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216592017883 Protein export membrane protein; Region: SecD_SecF; cl14618 216592017884 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592017885 12 probable transmembrane helices predicted for EC042_3549 by TMHMM2.0 at aa 11-33, 337-359, 366-388, 392-414, 438-460, 470-492, 540-562, 869-891, 896-918, 923-945, 974-996 and 1006-1028 216592017886 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 216592017887 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592017888 1 probable transmembrane helix predicted for EC042_3550 by TMHMM2.0 at aa 50-72 216592017889 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216592017890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592017891 substrate binding pocket [chemical binding]; other site 216592017892 membrane-bound complex binding site; other site 216592017893 hinge residues; other site 216592017894 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592017895 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 216592017896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592017897 conserved gate region; other site 216592017898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592017899 dimer interface [polypeptide binding]; other site 216592017900 conserved gate region; other site 216592017901 putative PBP binding loops; other site 216592017902 ABC-ATPase subunit interface; other site 216592017903 7 probable transmembrane helices predicted for EC042_3552 by TMHMM2.0 at aa 27-46, 89-111, 187-209, 222-241, 261-283, 340-359 and 369-391 216592017904 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.3e-18 216592017905 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592017906 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216592017907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592017908 dimer interface [polypeptide binding]; other site 216592017909 conserved gate region; other site 216592017910 putative PBP binding loops; other site 216592017911 ABC-ATPase subunit interface; other site 216592017912 8 probable transmembrane helices predicted for EC042_3553 by TMHMM2.0 at aa 29-51, 98-120, 127-149, 159-181, 202-224, 279-301, 306-324 and 328-350 216592017913 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-32 216592017914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216592017915 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216592017916 Walker A/P-loop; other site 216592017917 ATP binding site [chemical binding]; other site 216592017918 Q-loop/lid; other site 216592017919 ABC transporter signature motif; other site 216592017920 Walker B; other site 216592017921 D-loop; other site 216592017922 H-loop/switch region; other site 216592017923 HMMPfam hit to PF00005, ABC transporter, score 3.3e-67 216592017924 PS00017 ATP/GTP-binding site motif A (P-loop). 216592017925 PS00211 ABC transporters family signature. 216592017926 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216592017927 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 216592017928 trimer interface [polypeptide binding]; other site 216592017929 putative metal binding site [ion binding]; other site 216592017930 1 probable transmembrane helix predicted for EC042_3556 by TMHMM2.0 at aa 13-41 216592017931 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.5 216592017932 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 28 216592017933 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 216592017934 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 13 216592017935 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 216592017936 HMMPfam hit to PF07369, Protein of unknown function (DUF1488), score 4.8e-63 216592017937 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 216592017938 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216592017939 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216592017940 shikimate binding site; other site 216592017941 NAD(P) binding site [chemical binding]; other site 216592017942 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 1.9e-116 216592017943 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 216592017944 HMMPfam hit to PF01300, yrdC domain, score 5.5e-79 216592017945 PS01147 SUA5/yciO/yrdC family signature. 216592017946 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216592017947 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 216592017948 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216592017949 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216592017950 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 1.4e-18 216592017951 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 6.4e-21 216592017952 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 8.4e-20 216592017953 hypothetical protein; Validated; Region: PRK03430 216592017954 HMMPfam hit to PF04361, Protein of unknown function (DUF494), score 1.2e-112 216592017955 hypothetical protein; Provisional; Region: PRK10736 216592017956 DNA protecting protein DprA; Region: dprA; TIGR00732 216592017957 HMMPfam hit to PF02481, SMF family, score 4.5e-126 216592017958 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 216592017959 active site 216592017960 catalytic residues [active] 216592017961 metal binding site [ion binding]; metal-binding site 216592017962 HMMPfam hit to PF01327, Polypeptide deformylase, score 1.5e-90 216592017963 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 216592017964 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 216592017965 putative active site [active] 216592017966 substrate binding site [chemical binding]; other site 216592017967 putative cosubstrate binding site; other site 216592017968 catalytic site [active] 216592017969 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 216592017970 substrate binding site [chemical binding]; other site 216592017971 HMMPfam hit to PF00551, Formyl transferase, score 3e-84 216592017972 PS00373 Phosphoribosylglycinamide formyltransferase active site. 216592017973 HMMPfam hit to PF02911, Formyl transferase, C-terminal domain, score 2.4e-50 216592017974 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 216592017975 putative RNA binding site [nucleotide binding]; other site 216592017976 16S rRNA methyltransferase B; Provisional; Region: PRK10901 216592017977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592017978 S-adenosylmethionine binding site [chemical binding]; other site 216592017979 HMMPfam hit to PF01029, NusB family, score 3.3e-46 216592017980 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 6e-149 216592017981 PS01153 NOL1/NOP2/sun family signature. 216592017982 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 216592017983 TrkA-N domain; Region: TrkA_N; pfam02254 216592017984 TrkA-C domain; Region: TrkA_C; pfam02080 216592017985 TrkA-N domain; Region: TrkA_N; pfam02254 216592017986 TrkA-C domain; Region: TrkA_C; pfam02080 216592017987 HMMPfam hit to PF02254, TrkA-N domain, score 5.4e-20 216592017988 HMMPfam hit to PF02080, TrkA-C domain, score 2.3e-11 216592017989 HMMPfam hit to PF02254, TrkA-N domain, score 5.2e-14 216592017990 HMMPfam hit to PF02080, TrkA-C domain, score 3.9e-11 216592017991 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 216592017992 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 216592017993 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel,, score 2.3e-90 216592017994 PS01327 Large-conductance mechanosensitive channels mscL family signature. 216592017995 2 probable transmembrane helices predicted for EC042_3567 by TMHMM2.0 at aa 20-42 and 77-99 216592017996 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 216592017997 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 216592017998 DNA binding residues [nucleotide binding] 216592017999 dimer interface [polypeptide binding]; other site 216592018000 metal binding site [ion binding]; metal-binding site 216592018001 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.1e-08 216592018002 PS00552 Bacterial regulatory proteins, merR family signature. 216592018003 Predicted helix-turn-helix motif with score 1802.000, SD 5.32 at aa 2-23, sequence YRIGELAKMAEVTPDTIRYYEK 216592018004 hypothetical protein; Provisional; Region: PRK10203 216592018005 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 216592018006 HMMPfam hit to PF01196, Ribosomal protein L17, score 8.1e-66 216592018007 PS01167 Ribosomal protein L17 signature. 216592018008 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 216592018009 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 216592018010 alphaNTD homodimer interface [polypeptide binding]; other site 216592018011 alphaNTD - beta interaction site [polypeptide binding]; other site 216592018012 alphaNTD - beta' interaction site [polypeptide binding]; other site 216592018013 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 216592018014 HMMPfam hit to PF03118, Bacterial RNA polymerase, alpha chain C, score 1.7e-35 216592018015 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 1.4e-21 216592018016 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 8.3e-58 216592018017 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 216592018018 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 216592018019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592018020 RNA binding surface [nucleotide binding]; other site 216592018021 HMMPfam hit to PF01479, S4 domain, score 2.7e-21 216592018022 PS00632 Ribosomal protein S4 signature. 216592018023 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 1.2e-36 216592018024 30S ribosomal protein S11; Validated; Region: PRK05309 216592018025 HMMPfam hit to PF00411, Ribosomal protein S11, score 4.2e-76 216592018026 PS00054 Ribosomal protein S11 signature. 216592018027 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 216592018028 30S ribosomal protein S13; Region: bact_S13; TIGR03631 216592018029 HMMPfam hit to PF00416, Ribosomal protein S13/S18, score 2.6e-63 216592018030 PS00646 Ribosomal protein S13 signature. 216592018031 PS00061 Short-chain dehydrogenases/reductases family signature. 216592018032 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 216592018033 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 216592018034 SecY translocase; Region: SecY; pfam00344 216592018035 HMMPfam hit to PF00344, eubacterial secY protein, score 1.1e-204 216592018036 10 probable transmembrane helices predicted for EC042_3575 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414 216592018037 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216592018038 PS00756 Protein secY signature 2. 216592018039 PS00755 Protein secY signature 1. 216592018040 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 216592018041 HMMPfam hit to PF00256, Ribosomal protein L15, score 2.3e-10 216592018042 PS00475 Ribosomal protein L15 signature. 216592018043 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 1.5e-56 216592018044 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 216592018045 23S rRNA binding site [nucleotide binding]; other site 216592018046 HMMPfam hit to PF00327, Ribosomal protein L30p/L7e, score 1e-23 216592018047 PS00634 Ribosomal protein L30 signature. 216592018048 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 216592018049 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 216592018050 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 216592018051 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal domai, score 5.8e-43 216592018052 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal domai, score 4.3e-41 216592018053 PS00585 Ribosomal protein S5 signature. 216592018054 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 216592018055 23S rRNA interface [nucleotide binding]; other site 216592018056 5S rRNA interface [nucleotide binding]; other site 216592018057 L27 interface [polypeptide binding]; other site 216592018058 L5 interface [polypeptide binding]; other site 216592018059 HMMPfam hit to PF00861, Ribosomal L18p/L5e family, score 1.5e-52 216592018060 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 216592018061 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216592018062 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216592018063 HMMPfam hit to PF00347, Ribosomal protein L6, score 5.4e-30 216592018064 PS00525 Ribosomal protein L6 signature 1. 216592018065 HMMPfam hit to PF00347, Ribosomal protein L6, score 8.1e-22 216592018066 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 216592018067 HMMPfam hit to PF00410, Ribosomal protein S8, score 5.6e-72 216592018068 PS00294 Prenyl group binding site (CAAX box). 216592018069 PS00053 Ribosomal protein S8 signature. 216592018070 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 216592018071 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 4.3e-25 216592018072 PS00527 Ribosomal protein S14 signature. 216592018073 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 216592018074 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 216592018075 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 216592018076 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 1.4e-58 216592018077 HMMPfam hit to PF00281, Ribosomal protein L5, score 1.4e-33 216592018078 PS00358 Ribosomal protein L5 signature. 216592018079 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 216592018080 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 216592018081 RNA binding site [nucleotide binding]; other site 216592018082 HMMPfam hit to PF00467, KOW motif, score 5.7e-07 216592018083 PS01108 Ribosomal protein L24 signature. 216592018084 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 216592018085 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 7.7e-81 216592018086 PS00049 Ribosomal protein L14 signature. 216592018087 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 216592018088 HMMPfam hit to PF00366, Ribosomal protein S17, score 1.1e-42 216592018089 PS00056 Ribosomal protein S17 signature. 216592018090 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 216592018091 23S rRNA interface [nucleotide binding]; other site 216592018092 putative translocon interaction site; other site 216592018093 signal recognition particle (SRP54) interaction site; other site 216592018094 L23 interface [polypeptide binding]; other site 216592018095 trigger factor interaction site; other site 216592018096 HMMPfam hit to PF00831, Ribosomal L29 protein, score 7.2e-29 216592018097 PS00579 Ribosomal protein L29 signature. 216592018098 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 216592018099 23S rRNA interface [nucleotide binding]; other site 216592018100 5S rRNA interface [nucleotide binding]; other site 216592018101 putative antibiotic binding site [chemical binding]; other site 216592018102 L25 interface [polypeptide binding]; other site 216592018103 L27 interface [polypeptide binding]; other site 216592018104 HMMPfam hit to PF00252, Ribosomal protein L16, score 1.7e-92 216592018105 PS00701 Ribosomal protein L16 signature 2. 216592018106 PS00586 Ribosomal protein L16 signature 1. 216592018107 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 216592018108 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 216592018109 G-X-X-G motif; other site 216592018110 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 216592018111 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal domai, score 1.9e-54 216592018112 PS00548 Ribosomal protein S3 signature. 216592018113 HMMPfam hit to PF07650, KH domain, score 1.8e-19 216592018114 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal domai, score 5.2e-29 216592018115 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 216592018116 protein-rRNA interface [nucleotide binding]; other site 216592018117 putative translocon binding site; other site 216592018118 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 2.9e-60 216592018119 PS00464 Ribosomal protein L22 signature. 216592018120 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 216592018121 HMMPfam hit to PF00203, Ribosomal protein S19, score 3.9e-54 216592018122 PS00323 Ribosomal protein S19 signature. 216592018123 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 216592018124 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 216592018125 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 216592018126 HMMPfam hit to PF03947, Ribosomal Proteins L2, C-terminal doma, score 6.1e-83 216592018127 PS00467 Ribosomal protein L2 signature. 216592018128 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 1.1e-46 216592018129 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 216592018130 HMMPfam hit to PF00276, Ribosomal protein L23, score 1.9e-44 216592018131 PS00050 Ribosomal protein L23 signature. 216592018132 PS00430 TonB-dependent receptor proteins signature 1. 216592018133 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 216592018134 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 1.3e-54 216592018135 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 216592018136 HMMPfam hit to PF00297, Ribosomal protein L3, score 8.9e-106 216592018137 PS00474 Ribosomal protein L3 signature. 216592018138 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 216592018139 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 3.7e-59 216592018140 PS00361 Ribosomal protein S10 signature. 216592018141 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 216592018142 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 216592018143 4 probable transmembrane helices predicted for EC042_3597 by TMHMM2.0 at aa 5-23, 51-73, 101-123 and 133-152 216592018144 HMMPfam hit to PF01478, Type IV leader peptidase family, score 1.3e-22 216592018145 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 216592018146 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 216592018147 heme binding site [chemical binding]; other site 216592018148 ferroxidase pore; other site 216592018149 ferroxidase diiron center [ion binding]; other site 216592018150 HMMPfam hit to PF00210, Ferritin-like domain, score 2.5e-50 216592018151 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 216592018152 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 6.8e-20 216592018153 elongation factor Tu; Reviewed; Region: PRK00049 216592018154 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216592018155 G1 box; other site 216592018156 GEF interaction site [polypeptide binding]; other site 216592018157 GTP/Mg2+ binding site [chemical binding]; other site 216592018158 Switch I region; other site 216592018159 G2 box; other site 216592018160 G3 box; other site 216592018161 Switch II region; other site 216592018162 G4 box; other site 216592018163 G5 box; other site 216592018164 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216592018165 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216592018166 Antibiotic Binding Site [chemical binding]; other site 216592018167 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 1.4e-60 216592018168 HMMPfam hit to PF03144, Elongation factor Tu domain, score 8.6e-26 216592018169 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3e-97 216592018170 PS00301 GTP-binding elongation factors signature. 216592018171 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018172 elongation factor G; Reviewed; Region: PRK00007 216592018173 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 216592018174 G1 box; other site 216592018175 putative GEF interaction site [polypeptide binding]; other site 216592018176 GTP/Mg2+ binding site [chemical binding]; other site 216592018177 Switch I region; other site 216592018178 G2 box; other site 216592018179 G3 box; other site 216592018180 Switch II region; other site 216592018181 G4 box; other site 216592018182 G5 box; other site 216592018183 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 216592018184 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 216592018185 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 216592018186 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 2.4e-46 216592018187 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 3.9e-71 216592018188 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.3e-20 216592018189 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1e-112 216592018190 PS00301 GTP-binding elongation factors signature. 216592018191 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018192 30S ribosomal protein S7; Validated; Region: PRK05302 216592018193 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e, score 1.1e-88 216592018194 PS00052 Ribosomal protein S7 signature. 216592018195 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 216592018196 S17 interaction site [polypeptide binding]; other site 216592018197 S8 interaction site; other site 216592018198 16S rRNA interaction site [nucleotide binding]; other site 216592018199 streptomycin interaction site [chemical binding]; other site 216592018200 23S rRNA interaction site [nucleotide binding]; other site 216592018201 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 216592018202 HMMPfam hit to PF00164, Ribosomal protein S12, score 1.9e-76 216592018203 PS00055 Ribosomal protein S12 signature. 216592018204 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 216592018205 HMMPfam hit to PF04077, DsrH like protein, score 2.1e-45 216592018206 sulfur relay protein TusC; Validated; Region: PRK00211 216592018207 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 4.6e-48 216592018208 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 216592018209 HMMPfam hit to PF02635, DsrE/DsrF-like family, score 1.8e-61 216592018210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 216592018211 YheO-like PAS domain; Region: PAS_6; pfam08348 216592018212 HTH domain; Region: HTH_22; pfam13309 216592018213 Predicted helix-turn-helix motif with score 1347.000, SD 3.77 at aa 211-232, sequence DAINQVADRLNISKHTVYLYIR 216592018214 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 216592018215 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 216592018216 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216592018217 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 2e-47 216592018218 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216592018219 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 1.3e-63 216592018220 phi X174 lysis protein; Provisional; Region: PRK02793 216592018221 HMMPfam hit to PF04102, SlyX, score 1.4e-39 216592018222 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 216592018223 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216592018224 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 0.00073 216592018225 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216592018226 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216592018227 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 216592018228 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 216592018229 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 216592018230 TrkA-N domain; Region: TrkA_N; pfam02254 216592018231 HMMPfam hit to PF02254, TrkA-N domain, score 2.6e-09 216592018232 10 probable transmembrane helices predicted for EC042_3612 by TMHMM2.0 at aa 5-24, 29-51, 56-73, 86-108, 113-135, 148-170, 180-202, 223-245, 265-287 and 294-316 216592018233 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 216592018234 HMMPfam hit to PF02525, Flavodoxin-like fold, score 5e-70 216592018235 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 216592018236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592018237 Walker A/P-loop; other site 216592018238 ATP binding site [chemical binding]; other site 216592018239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592018240 ABC transporter signature motif; other site 216592018241 Walker B; other site 216592018242 D-loop; other site 216592018243 ABC transporter; Region: ABC_tran_2; pfam12848 216592018244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592018245 HMMPfam hit to PF00005, ABC transporter, score 2.3e-45 216592018246 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018247 PS00211 ABC transporters family signature. 216592018248 HMMPfam hit to PF00005, ABC transporter, score 7.9e-40 216592018249 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018250 PS00211 ABC transporters family signature. 216592018251 putative hydrolase; Provisional; Region: PRK10985 216592018252 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1e-30 216592018253 PS01133 Uncharacterized protein family UPF0017 signature. 216592018254 hypothetical protein; Provisional; Region: PRK04966 216592018255 HMMPfam hit to PF06794, Uncharacterised protein family (UPF0270), score 3.3e-50 216592018256 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 216592018257 active site 216592018258 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2.9e-125 216592018259 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018260 PS00567 Phosphoribulokinase signature. 216592018261 hypothetical protein; Provisional; Region: PRK10738 216592018262 HMMPfam hit to PF02566, OsmC-like protein, score 4.1e-49 216592018263 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 216592018264 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216592018265 ligand binding site [chemical binding]; other site 216592018266 flexible hinge region; other site 216592018267 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216592018268 putative switch regulator; other site 216592018269 non-specific DNA interactions [nucleotide binding]; other site 216592018270 DNA binding site [nucleotide binding] 216592018271 sequence specific DNA binding site [nucleotide binding]; other site 216592018272 putative cAMP binding site [chemical binding]; other site 216592018273 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.4e-32 216592018274 PS00888 Cyclic nucleotide-binding domain signature 1. 216592018275 PS00889 Cyclic nucleotide-binding domain signature 2. 216592018276 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 1.3e-15 216592018277 PS00042 Bacterial regulatory proteins, crp family signature. 216592018278 Predicted helix-turn-helix motif with score 2127.000, SD 6.43 at aa 168-189, sequence ITRQEIGQIVGCSRETVGRILK 216592018279 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 216592018280 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 216592018281 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592018282 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 5.9e-09 216592018283 9 probable transmembrane helices predicted for EC042_3621 by TMHMM2.0 at aa 20-42, 63-85, 89-111, 116-133, 138-160, 416-435, 440-457, 462-481 and 491-510 216592018284 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 216592018285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216592018286 inhibitor-cofactor binding pocket; inhibition site 216592018287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592018288 catalytic residue [active] 216592018289 HMMPfam hit to PF00202, Aminotransferase class-III, score 7.3e-209 216592018290 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216592018291 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 216592018292 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216592018293 glutamine binding [chemical binding]; other site 216592018294 catalytic triad [active] 216592018295 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.7e-87 216592018296 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018297 PS00442 Glutamine amidotransferases class-I active site. 216592018298 PS00678 Trp-Asp (WD) repeats signature. 216592018299 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 216592018300 cell filamentation protein Fic; Provisional; Region: PRK10347 216592018301 HMMPfam hit to PF02661, Fic protein family, score 1.4e-35 216592018302 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 216592018303 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 216592018304 substrate binding site [chemical binding]; other site 216592018305 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 5.6e-73 216592018306 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 216592018307 putative transporter; Provisional; Region: PRK03699 216592018308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592018309 putative substrate translocation pore; other site 216592018310 12 probable transmembrane helices predicted for EC042_3626 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121, 134-156, 161-183, 204-226, 246-268, 273-292, 296-318, 330-352 and 362-381 216592018311 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-18 216592018312 PS00217 Sugar transport proteins signature 2. 216592018313 nitrite reductase subunit NirD; Provisional; Region: PRK14989 216592018314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592018315 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216592018316 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216592018317 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216592018318 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 1e-85 216592018319 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 8.8e-25 216592018320 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 5.5e-21 216592018321 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 5.6e-48 216592018322 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 216592018323 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 216592018324 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592018325 nitrite transporter NirC; Provisional; Region: PRK11562 216592018326 HMMPfam hit to PF01226, Formate/nitrite transporter, score 3.8e-143 216592018327 6 probable transmembrane helices predicted for EC042_3629 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 150-172, 184-206 and 226-248 216592018328 PS01005 Formate and nitrite transporters signature 1. 216592018329 PS01006 Formate and nitrite transporters signature 2. 216592018330 siroheme synthase; Provisional; Region: cysG; PRK10637 216592018331 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 216592018332 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 216592018333 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 216592018334 active site 216592018335 SAM binding site [chemical binding]; other site 216592018336 homodimer interface [polypeptide binding]; other site 216592018337 Predicted helix-turn-helix motif with score 1145.000, SD 3.09 at aa 149-170, sequence LHLGQVAKYAGQLRGRVKQQFA 216592018338 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 2.6e-103 216592018339 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 216592018340 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 216592018341 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 216592018342 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018343 Present in 0157, absent in Uropathogenic, fructoselysine utilization operon (transporter, regulator, enzymes) 216592018344 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 216592018345 hypothetical protein; Provisional; Region: PHA02764 216592018346 11 probable transmembrane helices predicted for EC042_3632 by TMHMM2.0 at aa 10-32, 39-61, 97-119, 126-143, 153-175, 188-210, 230-252, 272-294, 341-363, 384-406 and 411-433 216592018347 HMMPfam hit to PF00324, Amino acid permease, score 5.3e-24 216592018348 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 216592018349 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 216592018350 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216592018351 dimer interface [polypeptide binding]; other site 216592018352 active site 216592018353 HMMPfam hit to PF01380, SIS domain, score 0.027 216592018354 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018355 HMMPfam hit to PF01380, SIS domain, score 0.031 216592018356 fructoselysine 3-epimerase; Provisional; Region: PRK09856 216592018357 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216592018358 AP (apurinic/apyrimidinic) site pocket; other site 216592018359 DNA interaction; other site 216592018360 Metal-binding active site; metal-binding site 216592018361 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.1e-39 216592018362 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 216592018363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592018364 substrate binding site [chemical binding]; other site 216592018365 ATP binding site [chemical binding]; other site 216592018366 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 5.2e-56 216592018367 PS00583 pfkB family of carbohydrate kinases signature 1. 216592018368 PS00584 pfkB family of carbohydrate kinases signature 2. 216592018369 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 216592018370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592018371 DNA-binding site [nucleotide binding]; DNA binding site 216592018372 UTRA domain; Region: UTRA; pfam07702 216592018373 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.2e-29 216592018374 PS00043 Bacterial regulatory proteins, gntR family signature. 216592018375 Predicted helix-turn-helix motif with score 1160.000, SD 3.14 at aa 36-57, sequence PTENELCTQYNVSRITIRKAIS 216592018376 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 8.9e-38 216592018377 Present in Uropathogenic, absent in 0157, misc. metabolism (contains phosphotriesterase family protein) 216592018378 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 216592018379 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 35-56, sequence LTRGDLGLTPGLNQPRITQRVE 216592018380 Protein of unknown function; Region: YhfT; pfam10797 216592018381 11 probable transmembrane helices predicted for EC042_3638 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 133-155, 159-176, 183-200, 229-251, 289-311, 321-343, 371-393 and 408-430 216592018382 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592018383 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 216592018384 1 probable transmembrane helix predicted for EC042_3639 by TMHMM2.0 at aa 47-69 216592018385 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 216592018386 active site 216592018387 substrate binding pocket [chemical binding]; other site 216592018388 homodimer interaction site [polypeptide binding]; other site 216592018389 HMMPfam hit to PF02126, Phosphotriesterase family, score 1.1e-196 216592018390 PS01323 Phosphotriesterase family signature 2. 216592018391 PS01322 Phosphotriesterase family signature 1. 216592018392 putative mutase; Provisional; Region: PRK12383 216592018393 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 216592018394 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 6.3e-39 216592018395 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 216592018396 dimer interface [polypeptide binding]; other site 216592018397 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 216592018398 active site 216592018399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592018400 substrate binding site [chemical binding]; other site 216592018401 catalytic residue [active] 216592018402 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 2.9e-42 216592018403 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 216592018404 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 216592018405 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 216592018406 active site 216592018407 HIGH motif; other site 216592018408 dimer interface [polypeptide binding]; other site 216592018409 KMSKS motif; other site 216592018410 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.8e-126 216592018411 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592018412 phosphoglycolate phosphatase; Provisional; Region: PRK13222 216592018413 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216592018414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592018415 motif II; other site 216592018416 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.5e-47 216592018417 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 216592018418 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 216592018419 substrate binding site [chemical binding]; other site 216592018420 hexamer interface [polypeptide binding]; other site 216592018421 metal binding site [ion binding]; metal-binding site 216592018422 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 4.8e-139 216592018423 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 216592018424 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 216592018425 DNA adenine methylase; Provisional; Region: PRK10904 216592018426 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 2.4e-104 216592018427 PS00092 N-6 Adenine-specific DNA methylases signature. 216592018428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 216592018429 cell division protein DamX; Validated; Region: PRK10905 216592018430 1 probable transmembrane helix predicted for EC042_3649 by TMHMM2.0 at aa 99-121 216592018431 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 216592018432 active site 216592018433 dimer interface [polypeptide binding]; other site 216592018434 metal binding site [ion binding]; metal-binding site 216592018435 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 1.3e-183 216592018436 shikimate kinase; Reviewed; Region: aroK; PRK00131 216592018437 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 216592018438 ADP binding site [chemical binding]; other site 216592018439 magnesium binding site [ion binding]; other site 216592018440 putative shikimate binding site; other site 216592018441 HMMPfam hit to PF01202, Shikimate kinase, score 3.2e-82 216592018442 PS01128 Shikimate kinase signature. 216592018443 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018444 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 216592018445 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216592018446 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 216592018447 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 2.3e-88 216592018448 PS00875 Bacterial type II secretion system protein D signature. 216592018449 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 3.6e-10 216592018450 HMMPfam hit to PF07660, Secretin and TonB N terminus short domain, score 8.9e-09 216592018451 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 216592018452 1 probable transmembrane helix predicted for EC042_3654 by TMHMM2.0 at aa 20-37 216592018453 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 216592018454 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 216592018455 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 2.5e-57 216592018456 1 probable transmembrane helix predicted for EC042_3655 by TMHMM2.0 at aa 21-40 216592018457 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 216592018458 Transglycosylase; Region: Transgly; pfam00912 216592018459 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216592018460 1 probable transmembrane helix predicted for EC042_3657 by TMHMM2.0 at aa 12-34 216592018461 HMMPfam hit to PF00912, Transglycosylase, score 4.9e-95 216592018462 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018463 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 5e-19 216592018464 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 216592018465 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216592018466 ADP-ribose binding site [chemical binding]; other site 216592018467 dimer interface [polypeptide binding]; other site 216592018468 active site 216592018469 nudix motif; other site 216592018470 metal binding site [ion binding]; metal-binding site 216592018471 HMMPfam hit to PF00293, NUDIX domain, score 3.9e-14 216592018472 PS00893 mutT domain signature. 216592018473 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 216592018474 HMMPfam hit to PF07095, Intracellular growth attenuator protein IgaA, score 0 216592018475 5 probable transmembrane helices predicted for EC042_3659 by TMHMM2.0 at aa 4-22, 202-221, 225-247, 336-358 and 652-674 216592018476 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 216592018477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592018478 motif II; other site 216592018479 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 8.1e-25 216592018480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592018481 RNA binding surface [nucleotide binding]; other site 216592018482 HMMPfam hit to PF01479, S4 domain, score 1.2e-12 216592018483 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 216592018484 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 216592018485 dimerization interface [polypeptide binding]; other site 216592018486 domain crossover interface; other site 216592018487 redox-dependent activation switch; other site 216592018488 HMMPfam hit to PF01430, Hsp33 protein, score 1e-144 216592018489 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 216592018490 11 probable transmembrane helices predicted for EC042_3663 by TMHMM2.0 at aa 12-34, 39-61, 66-84, 99-118, 138-160, 183-200, 213-235, 250-268, 289-308, 318-340 and 353-375 216592018491 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 216592018492 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 216592018493 active site 216592018494 substrate-binding site [chemical binding]; other site 216592018495 metal-binding site [ion binding] 216592018496 ATP binding site [chemical binding]; other site 216592018497 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, score 0 216592018498 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018499 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 216592018500 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 216592018501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592018502 dimerization interface [polypeptide binding]; other site 216592018503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592018504 dimer interface [polypeptide binding]; other site 216592018505 phosphorylation site [posttranslational modification] 216592018506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592018507 ATP binding site [chemical binding]; other site 216592018508 G-X-G motif; other site 216592018509 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 9.4e-35 216592018510 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.3e-14 216592018511 HMMPfam hit to PF00672, HAMP domain, score 1.7e-10 216592018512 2 probable transmembrane helices predicted for EC042_3665 by TMHMM2.0 at aa 15-37 and 160-179 216592018513 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592018514 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216592018515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592018516 active site 216592018517 phosphorylation site [posttranslational modification] 216592018518 intermolecular recognition site; other site 216592018519 dimerization interface [polypeptide binding]; other site 216592018520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592018521 DNA binding site [nucleotide binding] 216592018522 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.1e-20 216592018523 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.1e-44 216592018524 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 216592018525 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 216592018526 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216592018527 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 8.6e-45 216592018528 PS00829 Prokaryotic transcription elongation factors signature 1. 216592018529 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 3.9e-45 216592018530 PS00830 Prokaryotic transcription elongation factors signature 2. 216592018531 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 216592018532 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 216592018533 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 216592018534 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 216592018535 RNA binding site [nucleotide binding]; other site 216592018536 HMMPfam hit to PF00575, S1 RNA binding domain, score 5.3e-31 216592018537 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 216592018538 HMMPfam hit to PF04023, FeoA domain, score 1.4e-14 216592018539 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 216592018540 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 216592018541 G1 box; other site 216592018542 GTP/Mg2+ binding site [chemical binding]; other site 216592018543 Switch I region; other site 216592018544 G2 box; other site 216592018545 G3 box; other site 216592018546 Switch II region; other site 216592018547 G4 box; other site 216592018548 G5 box; other site 216592018549 Nucleoside recognition; Region: Gate; pfam07670 216592018550 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 216592018551 Nucleoside recognition; Region: Gate; pfam07670 216592018552 HMMPfam hit to PF01926, GTPase of unknown function, score 9e-39 216592018553 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018554 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 1.9e-48 216592018555 10 probable transmembrane helices predicted for EC042_3670 by TMHMM2.0 at aa 281-303, 313-335, 348-370, 390-412, 425-447, 457-479, 514-536, 667-689, 696-718 and 724-746 216592018556 HMMPfam hit to PF07670, Nucleoside recognition, score 4e-14 216592018557 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018558 HMMPfam hit to PF07664, Ferrous iron transport protein B C terminus, score 1.4e-22 216592018559 HMMPfam hit to PF07670, Nucleoside recognition, score 5.6e-17 216592018560 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 216592018561 Predicted helix-turn-helix motif with score 988.000, SD 2.55 at aa 20-41, sequence MEAAQISQALNTPQPMINAMLQ 216592018562 putative transposase; Provisional; Region: PRK09857 216592018563 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 216592018564 HMMPfam hit to PF04754, Putative transposase, YhgA-like, score 6.2e-213 216592018565 carboxylesterase BioH; Provisional; Region: PRK10349 216592018566 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216592018567 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.2e-41 216592018568 DNA utilization protein GntX; Provisional; Region: PRK11595 216592018569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592018570 active site 216592018571 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592018572 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 216592018573 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 216592018574 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 216592018575 HMMPfam hit to PF01521, HesB-like domain, score 7.1e-40 216592018576 HMMPfam hit to PF01106, NifU-like domain, score 6.9e-07 216592018577 high-affinity gluconate transporter; Provisional; Region: PRK14984 216592018578 gluconate transporter; Region: gntP; TIGR00791 216592018579 HMMPfam hit to PF02447, GntP family permease, score 5e-294 216592018580 11 probable transmembrane helices predicted for EC042_3676 by TMHMM2.0 at aa 15-37, 50-72, 97-119, 124-146, 175-197, 221-243, 258-280, 293-312, 349-371, 378-400 and 415-437 216592018581 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 216592018582 4-alpha-glucanotransferase; Region: malQ; TIGR00217 216592018583 HMMPfam hit to PF02446, 4-alpha-glucanotransferase, score 9.4e-281 216592018584 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018585 maltodextrin phosphorylase; Provisional; Region: PRK14985 216592018586 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 216592018587 homodimer interface [polypeptide binding]; other site 216592018588 active site pocket [active] 216592018589 HMMPfam hit to PF00343, Carbohydrate phosphorylase, score 0 216592018590 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 216592018591 transcriptional regulator MalT; Provisional; Region: PRK04841 216592018592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592018593 DNA binding residues [nucleotide binding] 216592018594 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.21 216592018595 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 3.2e-24 216592018596 PS00622 Bacterial regulatory proteins, luxR family signature. 216592018597 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 216592018598 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 216592018599 putative active site [active] 216592018600 HMMPfam hit to PF01137, RNA 3'-terminal phosphate cyclase, score 2e-110 216592018601 HMMPfam hit to PF05189, RNA 3'-terminal phosphate cyclase (RTC), i, score 9.2e-27 216592018602 PS01287 RNA 3'-terminal phosphate cyclase signature. 216592018603 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 216592018604 hypothetical protein; Reviewed; Region: PRK09588 216592018605 HMMPfam hit to PF01139, Uncharacterized protein family UPF0027, score 4.9e-210 216592018606 PS01288 Uncharacterized protein family UPF0027 signature. 216592018607 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 216592018608 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 216592018609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592018610 Walker A motif; other site 216592018611 ATP binding site [chemical binding]; other site 216592018612 Walker B motif; other site 216592018613 arginine finger; other site 216592018614 HMMPfam hit to PF06956, Regulator of RNA terminal phosphate c, score 3.7e-141 216592018615 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 4.6e-90 216592018616 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018617 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592018618 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 216592018619 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216592018620 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592018621 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.7e-129 216592018622 Predicted helix-turn-helix motif with score 1617.000, SD 4.69 at aa 20-41, sequence VSTEELVEHFSVSPQTIRRDLN 216592018623 PS00894 Bacterial regulatory proteins, deoR family signature. 216592018624 intramembrane serine protease GlpG; Provisional; Region: PRK10907 216592018625 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 216592018626 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 216592018627 HMMPfam hit to PF01694, Rhomboid family, score 3.4e-41 216592018628 6 probable transmembrane helices predicted for EC042_3684 by TMHMM2.0 at aa 93-115, 135-157, 169-188, 192-214, 223-245 and 250-272 216592018629 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 216592018630 active site residue [active] 216592018631 HMMPfam hit to PF00581, Rhodanese-like domain, score 4.2e-21 216592018632 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 216592018633 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.7e-71 216592018634 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 216592018635 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 216592018636 1 probable transmembrane helix predicted for EC042_3687 by TMHMM2.0 at aa 15-37 216592018637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018638 Fimbrial operon 10. Sequence divergence between 0157 and Uropathogenic strains 216592018639 Fimbrial protein; Region: Fimbrial; cl01416 216592018640 HMMPfam hit to PF00419, Fimbrial protein, score 0.0034 216592018641 1 probable transmembrane helix predicted for EC042_3688 by TMHMM2.0 at aa 7-29 216592018642 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018643 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 216592018644 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592018645 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592018646 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 7.5e-06 216592018647 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.7e-26 216592018648 1 probable transmembrane helix predicted for EC042_3689 by TMHMM2.0 at aa 12-34 216592018649 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592018650 HMMPfam hit to PF00419, Fimbrial protein, score 6.2e-30 216592018651 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592018652 HMMPfam hit to PF00419, Fimbrial protein, score 3.7e-41 216592018653 outer membrane usher protein; Provisional; Region: PRK15193 216592018654 PapC N-terminal domain; Region: PapC_N; pfam13954 216592018655 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592018656 PapC C-terminal domain; Region: PapC_C; pfam13953 216592018657 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592018658 1 probable transmembrane helix predicted for EC042_3692 by TMHMM2.0 at aa 21-39 216592018660 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.6e-19 216592018661 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 9.1e-10 216592018662 PS00635 Gram-negative pili assembly chaperone signature. 216592018663 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 216592018664 HMMPfam hit to PF00419, Fimbrial protein, score 1.5e-24 216592018665 glycogen phosphorylase; Provisional; Region: PRK14986 216592018666 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 216592018667 homodimer interface [polypeptide binding]; other site 216592018668 active site pocket [active] 216592018669 HMMPfam hit to PF00343, Carbohydrate phosphorylase, score 0 216592018670 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 216592018671 glycogen synthase; Provisional; Region: glgA; PRK00654 216592018672 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 216592018673 ADP-binding pocket [chemical binding]; other site 216592018674 homodimer interface [polypeptide binding]; other site 216592018675 HMMPfam hit to PF00534, Glycosyl transferases group, score 9.1e-09 216592018676 PS00589 PTS HPR component serine phosphorylation site signature. 216592018677 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 216592018678 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 216592018679 ligand binding site; other site 216592018680 oligomer interface; other site 216592018681 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 216592018682 sulfate 1 binding site; other site 216592018683 HMMPfam hit to PF00483, Nucleotidyl transferase, score 8.1e-102 216592018684 PS00810 ADP-glucose pyrophosphorylase signature 3. 216592018685 PS00809 ADP-glucose pyrophosphorylase signature 2. 216592018686 PS00808 ADP-glucose pyrophosphorylase signature 1. 216592018687 glycogen debranching enzyme; Provisional; Region: PRK03705 216592018688 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 216592018689 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 216592018690 active site 216592018691 catalytic site [active] 216592018692 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.2e-10 216592018693 PS00062 Aldo/keto reductase family signature 2. 216592018694 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.1e-34 216592018695 glycogen branching enzyme; Provisional; Region: PRK05402 216592018696 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 216592018697 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 216592018698 active site 216592018699 catalytic site [active] 216592018700 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216592018701 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.1e-07 216592018702 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 2.8e-40 216592018703 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 216592018704 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216592018705 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 1.6e-85 216592018706 PS01103 Aspartate-semialdehyde dehydrogenase signature. 216592018707 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 6.3e-48 216592018708 putative antibiotic transporter; Provisional; Region: PRK10739 216592018709 HMMPfam hit to PF01914, MarC family integral membrane protein, score 3.1e-94 216592018710 6 probable transmembrane helices predicted for EC042_3701 by TMHMM2.0 at aa 4-26, 38-57, 72-94, 106-128, 138-160 and 173-195 216592018711 low affinity gluconate transporter; Provisional; Region: PRK10472 216592018712 gluconate transporter; Region: gntP; TIGR00791 216592018713 13 probable transmembrane helices predicted for EC042_3702 by TMHMM2.0 at aa 4-21, 28-47, 57-79, 104-126, 146-168, 175-197, 228-250, 262-284, 299-321, 328-350, 354-373, 386-408 and 423-445 216592018714 HMMPfam hit to PF02447, GntP family permease, score 1.2e-259 216592018715 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216592018716 ATP-binding site [chemical binding]; other site 216592018717 Gluconate-6-phosphate binding site [chemical binding]; other site 216592018718 Shikimate kinase; Region: SKI; pfam01202 216592018719 HMMPfam hit to PF01202, Shikimate kinase, score 1.9e-08 216592018720 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018721 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 216592018722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592018723 DNA binding site [nucleotide binding] 216592018724 domain linker motif; other site 216592018725 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216592018726 putative ligand binding site [chemical binding]; other site 216592018727 putative dimerization interface [polypeptide binding]; other site 216592018728 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 4.9e-25 216592018729 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.9e-09 216592018730 Predicted helix-turn-helix motif with score 1844.000, SD 5.47 at aa 6-27, sequence PVLQDVADRVGVTKMTVSRFLR 216592018731 PS00356 Bacterial regulatory proteins, lacI family signature. 216592018732 Pirin-related protein [General function prediction only]; Region: COG1741 216592018733 Pirin; Region: Pirin; pfam02678 216592018734 HMMPfam hit to PF02678, Pirin, score 2.2e-66 216592018735 putative oxidoreductase; Provisional; Region: PRK10206 216592018736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216592018737 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216592018738 HMMPfam hit to PF02894, Oxidoreductase family, C-terminal alph, score 4.1e-20 216592018739 HMMPfam hit to PF01408, Oxidoreductase family, NAD-binding Ros, score 8e-45 216592018740 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018741 putative acetyltransferase YhhY; Provisional; Region: PRK10140 216592018742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592018743 Coenzyme A binding pocket [chemical binding]; other site 216592018744 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1e-18 216592018745 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 216592018746 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 216592018747 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 2.8e-281 216592018748 PS00462 Gamma-glutamyltranspeptidase signature. 216592018749 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018750 hypothetical protein; Provisional; Region: PRK10350 216592018751 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 216592018752 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 216592018753 putative active site [active] 216592018754 catalytic site [active] 216592018755 putative metal binding site [ion binding]; other site 216592018756 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 8.7e-72 216592018757 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216592018758 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216592018759 Walker A/P-loop; other site 216592018760 ATP binding site [chemical binding]; other site 216592018761 Q-loop/lid; other site 216592018762 ABC transporter signature motif; other site 216592018763 Walker B; other site 216592018764 D-loop; other site 216592018765 H-loop/switch region; other site 216592018766 TOBE domain; Region: TOBE_2; pfam08402 216592018767 HMMPfam hit to PF03459, TOBE domain, score 3.2e-07 216592018768 HMMPfam hit to PF00005, ABC transporter, score 1.7e-60 216592018769 PS00211 ABC transporters family signature. 216592018770 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216592018772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592018773 dimer interface [polypeptide binding]; other site 216592018774 conserved gate region; other site 216592018775 putative PBP binding loops; other site 216592018776 ABC-ATPase subunit interface; other site 216592018777 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.4e-31 216592018778 6 probable transmembrane helices predicted for EC042_3712 by TMHMM2.0 at aa 7-29, 82-104, 111-130, 145-162, 200-222 and 251-273 216592018779 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592018780 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216592018781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592018782 dimer interface [polypeptide binding]; other site 216592018783 conserved gate region; other site 216592018784 putative PBP binding loops; other site 216592018785 ABC-ATPase subunit interface; other site 216592018786 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.4e-23 216592018787 6 probable transmembrane helices predicted for EC042_3713 by TMHMM2.0 at aa 12-34, 79-101, 108-130, 155-177, 206-228 and 266-288 216592018788 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592018789 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 216592018790 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216592018791 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.5e-38 216592018792 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 216592018793 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 216592018794 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216592018795 Walker A/P-loop; other site 216592018796 ATP binding site [chemical binding]; other site 216592018797 Q-loop/lid; other site 216592018798 ABC transporter signature motif; other site 216592018799 Walker B; other site 216592018800 D-loop; other site 216592018801 H-loop/switch region; other site 216592018802 HMMPfam hit to PF00005, ABC transporter, score 9.3e-58 216592018803 PS00211 ABC transporters family signature. 216592018804 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018805 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 216592018806 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216592018807 Walker A/P-loop; other site 216592018808 ATP binding site [chemical binding]; other site 216592018809 Q-loop/lid; other site 216592018810 ABC transporter signature motif; other site 216592018811 Walker B; other site 216592018812 D-loop; other site 216592018813 H-loop/switch region; other site 216592018814 HMMPfam hit to PF00005, ABC transporter, score 1.2e-58 216592018815 PS00211 ABC transporters family signature. 216592018816 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018817 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 216592018818 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 216592018819 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216592018820 TM-ABC transporter signature motif; other site 216592018821 10 probable transmembrane helices predicted for EC042_3717 by TMHMM2.0 at aa 4-26, 47-66, 91-108, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 381-400 216592018822 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.2e-75 216592018823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592018824 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216592018825 TM-ABC transporter signature motif; other site 216592018826 8 probable transmembrane helices predicted for EC042_3718 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301 216592018827 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 4e-69 216592018828 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216592018829 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216592018830 dimerization interface [polypeptide binding]; other site 216592018831 ligand binding site [chemical binding]; other site 216592018832 HMMPfam hit to PF01094, Receptor family ligand binding region, score 3.1e-75 216592018833 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 216592018834 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.00028 216592018835 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216592018836 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216592018837 dimerization interface [polypeptide binding]; other site 216592018838 ligand binding site [chemical binding]; other site 216592018839 HMMPfam hit to PF01094, Receptor family ligand binding region, score 1.5e-71 216592018840 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 216592018841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592018842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592018843 DNA binding residues [nucleotide binding] 216592018844 HMMPfam hit to PF04545, Sigma-70, region, score 1.4e-18 216592018845 PS00716 Sigma-70 factors family signature 2. 216592018846 Predicted helix-turn-helix motif with score 2058.000, SD 6.20 at aa 251-272, sequence STLQELADRYGVSAERVRQLEK 216592018847 HMMPfam hit to PF04542, Sigma-70 region, score 4.6e-22 216592018848 PS00715 Sigma-70 factors family signature 1. 216592018849 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 216592018850 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 216592018851 HMMPfam hit to PF02687, Predicted permease, score 7.3e-25 216592018852 4 probable transmembrane helices predicted for EC042_3723 by TMHMM2.0 at aa 73-95, 219-241, 274-296 and 317-339 216592018853 cell division protein FtsE; Provisional; Region: PRK10908 216592018854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592018855 Walker A/P-loop; other site 216592018856 ATP binding site [chemical binding]; other site 216592018857 Q-loop/lid; other site 216592018858 ABC transporter signature motif; other site 216592018859 Walker B; other site 216592018860 D-loop; other site 216592018861 H-loop/switch region; other site 216592018862 HMMPfam hit to PF00005, ABC transporter, score 3.2e-75 216592018863 PS00211 ABC transporters family signature. 216592018864 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018865 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 216592018866 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 216592018867 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216592018868 P loop; other site 216592018869 GTP binding site [chemical binding]; other site 216592018870 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 7.8e-127 216592018871 PS00300 SRP54-type proteins GTP-binding domain signature. 216592018872 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018873 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 8.3e-20 216592018874 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 216592018875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592018876 S-adenosylmethionine binding site [chemical binding]; other site 216592018877 HMMPfam hit to PF03602, Conserved hypothetical protein, score 2.2e-93 216592018878 PS00092 N-6 Adenine-specific DNA methylases signature. 216592018879 hypothetical protein; Provisional; Region: PRK10910 216592018880 HMMPfam hit to PF06611, Protein of unknown function (DUF1145), score 3.5e-46 216592018881 2 probable transmembrane helices predicted for EC042_3727 by TMHMM2.0 at aa 4-23 and 30-52 216592018882 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 216592018883 1 probable transmembrane helix predicted for EC042_3728 by TMHMM2.0 at aa 5-24 216592018884 Predicted membrane protein [Function unknown]; Region: COG3714 216592018885 6 probable transmembrane helices predicted for EC042_3729 by TMHMM2.0 at aa 28-45, 50-72, 79-96, 101-123, 130-152 and 156-178 216592018886 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 216592018887 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216592018888 metal-binding site [ion binding] 216592018889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216592018890 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216592018891 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1e-11 216592018892 PS01047 Heavy-metal-associated domain. 216592018893 5 probable transmembrane helices predicted for EC042_3730 by TMHMM2.0 at aa 147-169, 189-211, 350-372, 387-409 and 690-712 216592018894 HMMPfam hit to PF00122, E1-E2 ATPase, score 4.1e-92 216592018895 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592018896 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.3e-29 216592018897 PS00154 E1-E2 ATPases phosphorylation site. 216592018898 PS01229 Hypothetical cof family signature 2. 216592018899 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592018900 3 probable transmembrane helices predicted for EC042_3731 by TMHMM2.0 at aa 7-29, 39-61 and 73-95 216592018901 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 216592018902 CPxP motif; other site 216592018903 HMMPfam hit to PF01206, SirA-like protein, score 1.1e-42 216592018904 PS01148 Uncharacterized protein family UPF0033 signature. 216592018905 hypothetical protein; Provisional; Region: PRK11212 216592018906 6 probable transmembrane helices predicted for EC042_3733 by TMHMM2.0 at aa 13-32, 42-64, 71-93, 108-130, 142-164 and 179-201 216592018907 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 5e-73 216592018908 hypothetical protein; Provisional; Region: PRK11615 216592018909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018910 major facilitator superfamily transporter; Provisional; Region: PRK05122 216592018911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592018912 putative substrate translocation pore; other site 216592018913 12 probable transmembrane helices predicted for EC042_3735 by TMHMM2.0 at aa 33-55, 65-87, 99-121, 136-158, 165-187, 191-213, 234-256, 266-285, 292-314, 324-346, 353-375 and 380-402 216592018914 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.9e-24 216592018915 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 216592018916 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216592018917 8 probable transmembrane helices predicted for EC042_3736 by TMHMM2.0 at aa 37-56, 60-82, 89-111, 168-190, 224-246, 251-273, 280-302 and 322-344 216592018918 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.2e-102 216592018919 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 216592018920 Present in 0157, UPEC strain CFT073, ETEC. absent in APEC, EPEC, ETEC and UPEC strains UTI89 and 536. Carries misc. secondary metaoblism (fatty acid like?) 216592018921 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592018923 S-adenosylmethionine binding site [chemical binding]; other site 216592018924 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 216592018925 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216592018926 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216592018927 putative acyl-acceptor binding pocket; other site 216592018928 1 probable transmembrane helix predicted for EC042_3740 by TMHMM2.0 at aa 21-43 216592018929 HMMPfam hit to PF01553, Acyltransferase, score 8.9e-16 216592018930 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216592018931 PS00012 Phosphopantetheine attachment site. 216592018932 acyl carrier protein; Provisional; Region: PRK05350 216592018933 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 5.6e-11 216592018934 Predicted membrane protein [Function unknown]; Region: COG4648 216592018935 6 probable transmembrane helices predicted for EC042_3743 by TMHMM2.0 at aa 7-29, 33-49, 61-80, 85-107, 137-156 and 161-183 216592018936 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 216592018937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216592018938 acyl-activating enzyme (AAE) consensus motif; other site 216592018939 active site 216592018940 AMP binding site [chemical binding]; other site 216592018941 CoA binding site [chemical binding]; other site 216592018942 PS00579 Ribosomal protein L29 signature. 216592018943 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.5e-07 216592018944 PS00017 ATP/GTP-binding site motif A (P-loop). 216592018945 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 216592018946 active site 2 [active] 216592018947 active site 1 [active] 216592018948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216592018949 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216592018950 Ligand binding site; other site 216592018951 Putative Catalytic site; other site 216592018952 DXD motif; other site 216592018953 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216592018954 putative acyl-acceptor binding pocket; other site 216592018955 HMMPfam hit to PF00535, Glycosyl transferase, score 3.2e-15 216592018956 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216592018957 active site 216592018958 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.7e-08 216592018959 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 216592018960 Predicted exporter [General function prediction only]; Region: COG4258 216592018961 12 probable transmembrane helices predicted for EC042_3749 by TMHMM2.0 at aa 13-35, 258-277, 284-306, 310-332, 353-375, 379-401, 429-448, 630-652, 659-681, 685-707, 714-736 and 741-763 216592018962 Predicted helix-turn-helix motif with score 1101.000, SD 2.94 at aa 376-397, sequence IRQMAIFAAVGLSASCLTVLFW 216592018963 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 216592018964 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592018965 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 216592018966 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216592018967 dimer interface [polypeptide binding]; other site 216592018968 active site 216592018969 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 3.3e-09 216592018970 PS00606 Beta-ketoacyl synthases active site. 216592018971 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 5.4e-34 216592018972 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 216592018973 putative active site 1 [active] 216592018974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216592018975 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 216592018976 NAD(P) binding site [chemical binding]; other site 216592018977 active site 216592018978 HMMPfam hit to PF00106, short chain dehydrogenase, score 1.7e-69 216592018979 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 216592018980 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216592018981 dimer interface [polypeptide binding]; other site 216592018982 active site 216592018983 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 3.2e-45 216592018984 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.9e-49 216592018985 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 216592018986 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 216592018987 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 0.0017 216592018988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216592018989 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 216592018990 substrate binding site [chemical binding]; other site 216592018991 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 5.6e-82 216592018992 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592018993 nickel transporter permease NikB; Provisional; Region: PRK10352 216592018994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592018995 dimer interface [polypeptide binding]; other site 216592018996 conserved gate region; other site 216592018997 putative PBP binding loops; other site 216592018998 ABC-ATPase subunit interface; other site 216592018999 6 probable transmembrane helices predicted for EC042_3757 by TMHMM2.0 at aa 9-31, 101-123, 136-158, 173-195, 230-252 and 280-302 216592019000 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.4e-68 216592019001 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 216592019002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592019003 dimer interface [polypeptide binding]; other site 216592019004 conserved gate region; other site 216592019005 putative PBP binding loops; other site 216592019006 ABC-ATPase subunit interface; other site 216592019007 6 probable transmembrane helices predicted for EC042_3758 by TMHMM2.0 at aa 13-32, 78-100, 121-143, 179-198, 205-227 and 242-260 216592019008 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-47 216592019009 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 216592019010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592019011 Walker A/P-loop; other site 216592019012 ATP binding site [chemical binding]; other site 216592019013 Q-loop/lid; other site 216592019014 ABC transporter signature motif; other site 216592019015 Walker B; other site 216592019016 D-loop; other site 216592019017 H-loop/switch region; other site 216592019018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592019019 HMMPfam hit to PF00005, ABC transporter, score 5.5e-53 216592019020 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019021 PS00211 ABC transporters family signature. 216592019022 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 216592019023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592019024 Walker A/P-loop; other site 216592019025 ATP binding site [chemical binding]; other site 216592019026 Q-loop/lid; other site 216592019027 ABC transporter signature motif; other site 216592019028 Walker B; other site 216592019029 D-loop; other site 216592019030 H-loop/switch region; other site 216592019031 HMMPfam hit to PF00005, ABC transporter, score 1.6e-75 216592019032 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019033 PS00211 ABC transporters family signature. 216592019034 nickel responsive regulator; Provisional; Region: PRK02967 216592019035 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 216592019036 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 3.7e-12 216592019037 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216592019038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592019039 DNA-binding site [nucleotide binding]; DNA binding site 216592019040 UTRA domain; Region: UTRA; pfam07702 216592019041 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.1e-15 216592019042 PS00043 Bacterial regulatory proteins, gntR family signature. 216592019043 Predicted helix-turn-helix motif with score 1094.000, SD 2.91 at aa 39-60, sequence PSEYQIMDMLEVSRGTVKKAVA 216592019044 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.5e-30 216592019045 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592019046 active site 216592019047 phosphorylation site [posttranslational modification] 216592019048 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 4.3e-06 216592019049 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 216592019050 active site 216592019051 P-loop; other site 216592019052 phosphorylation site [posttranslational modification] 216592019053 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 9e-05 216592019054 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 216592019055 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 216592019056 10 probable transmembrane helices predicted for EC042_3765 by TMHMM2.0 at aa 21-43, 58-80, 107-129, 152-174, 187-209, 235-257, 262-284, 308-330, 374-396 and 431-453 216592019057 HMMPfam hit to PF03611, PTS system Galactitol-specific IIC component, score 8.1e-131 216592019058 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216592019059 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 216592019060 putative N- and C-terminal domain interface [polypeptide binding]; other site 216592019061 putative active site [active] 216592019062 putative MgATP binding site [chemical binding]; other site 216592019063 catalytic site [active] 216592019064 metal binding site [ion binding]; metal-binding site 216592019065 putative carbohydrate binding site [chemical binding]; other site 216592019066 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.2e-35 216592019067 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 2.3e-09 216592019068 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592019069 dimerization domain swap beta strand [polypeptide binding]; other site 216592019070 regulatory protein interface [polypeptide binding]; other site 216592019071 active site 216592019072 regulatory phosphorylation site [posttranslational modification]; other site 216592019073 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 2.2e-27 216592019074 PS00369 PTS HPR component histidine phosphorylation site signature. 216592019075 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019076 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 216592019077 intersubunit interface [polypeptide binding]; other site 216592019078 active site 216592019079 zinc binding site [ion binding]; other site 216592019080 Na+ binding site [ion binding]; other site 216592019081 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 3.7e-49 216592019082 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 216592019083 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216592019084 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216592019085 5 probable transmembrane helices predicted for EC042_3769 by TMHMM2.0 at aa 202-224, 254-276, 286-308, 315-332 and 372-394 216592019086 HMMPfam hit to PF01061, ABC-2 type transporter, score 4.2e-36 216592019087 PS00890 ABC-2 type transport system integral membrane proteins signature. 216592019088 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216592019089 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216592019090 Walker A/P-loop; other site 216592019091 ATP binding site [chemical binding]; other site 216592019092 Q-loop/lid; other site 216592019093 ABC transporter signature motif; other site 216592019094 Walker B; other site 216592019095 D-loop; other site 216592019096 H-loop/switch region; other site 216592019097 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216592019098 Walker A/P-loop; other site 216592019099 ATP binding site [chemical binding]; other site 216592019100 Q-loop/lid; other site 216592019101 ABC transporter signature motif; other site 216592019102 Walker B; other site 216592019103 D-loop; other site 216592019104 H-loop/switch region; other site 216592019105 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216592019106 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 216592019107 5 probable transmembrane helices predicted for EC042_3770 by TMHMM2.0 at aa 717-739, 768-790, 795-817, 824-841 and 884-906 216592019108 HMMPfam hit to PF01061, ABC-2 type transporter, score 1.3e-17 216592019109 HMMPfam hit to PF00005, ABC transporter, score 2e-53 216592019110 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019111 HMMPfam hit to PF00005, ABC transporter, score 1e-63 216592019112 PS00211 ABC transporters family signature. 216592019113 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019114 HlyD family secretion protein; Region: HlyD; pfam00529 216592019115 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592019116 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592019117 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.3e-44 216592019118 1 probable transmembrane helix predicted for EC042_3771 by TMHMM2.0 at aa 7-26 216592019119 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 216592019120 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 216592019121 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 216592019122 10 probable transmembrane helices predicted for EC042_3774 by TMHMM2.0 at aa 40-62, 72-94, 107-129, 144-166, 186-208, 223-245, 258-280, 290-312, 324-343 and 358-380 216592019123 Predicted flavoproteins [General function prediction only]; Region: COG2081 216592019124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592019125 HMMPfam hit to PF03486, HI0933-like protein, score 1.3e-210 216592019126 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216592019127 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216592019128 10 probable transmembrane helices predicted for EC042_3776 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145, 155-177, 207-224, 234-256, 381-403, 418-440 and 474-496 216592019129 HMMPfam hit to PF01384, Phosphate transporter family, score 2e-149 216592019130 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592019131 universal stress protein UspB; Provisional; Region: PRK04960 216592019132 2 probable transmembrane helices predicted for EC042_3777 by TMHMM2.0 at aa 5-24 and 90-109 216592019133 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592019134 Ligand Binding Site [chemical binding]; other site 216592019135 HMMPfam hit to PF00582, Universal stress protein family, score 2.6e-16 216592019136 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 216592019137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592019138 POT family; Region: PTR2; pfam00854 216592019139 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-06 216592019140 14 probable transmembrane helices predicted for EC042_3779 by TMHMM2.0 at aa 20-42, 52-74, 83-102, 107-124, 145-167, 171-193, 214-233, 237-255, 268-290, 314-336, 349-371, 386-408, 415-437 and 457-479 216592019141 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 216592019142 HMMPfam hit to PF00854, POT family, score 8.3e-116 216592019143 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 216592019144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592019145 S-adenosylmethionine binding site [chemical binding]; other site 216592019146 HMMPfam hit to PF04445, Protein of unknown function (DUF548), score 1.1e-167 216592019147 oligopeptidase A; Provisional; Region: PRK10911 216592019148 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 216592019149 active site 216592019150 Zn binding site [ion binding]; other site 216592019151 HMMPfam hit to PF01432, Peptidase family M3, score 2.7e-249 216592019152 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592019153 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 216592019154 HMMPfam hit to PF04378, Protein of unknown function (DUF519), score 1.1e-173 216592019155 PS00092 N-6 Adenine-specific DNA methylases signature. 216592019156 PS00092 N-6 Adenine-specific DNA methylases signature. 216592019157 glutathione reductase; Validated; Region: PRK06116 216592019158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592019159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592019160 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216592019161 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 4.3e-93 216592019162 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216592019163 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 3.5e-53 216592019164 Partially present in 0157 and Uropathogenic, arsenical resistance cluster (region deleted in other E. coli, 042 contains extra arsD and arsA) 216592019165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592019166 dimerization interface [polypeptide binding]; other site 216592019167 putative DNA binding site [nucleotide binding]; other site 216592019168 putative Zn2+ binding site [ion binding]; other site 216592019169 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 8.5e-29 216592019170 Predicted helix-turn-helix motif with score 1087.000, SD 2.89 at aa 31-52, sequence LCVCDLCTALDQSQPKISRHLA 216592019171 PS00846 Bacterial regulatory proteins, arsR family signature. 216592019172 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 216592019173 HMMPfam hit to PF06953, Arsenical resistance operon trans-acting rep, score 8.6e-86 216592019174 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 216592019175 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216592019176 P loop; other site 216592019177 Nucleotide binding site [chemical binding]; other site 216592019178 DTAP/Switch II; other site 216592019179 Switch I; other site 216592019180 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216592019181 P loop; other site 216592019182 Nucleotide binding site [chemical binding]; other site 216592019183 DTAP/Switch II; other site 216592019184 Switch I; other site 216592019185 HMMPfam hit to PF02374, Anion-transporting ATPase, score 2.5e-131 216592019186 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019187 HMMPfam hit to PF02374, Anion-transporting ATPase, score 8.9e-16 216592019188 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019189 arsenical pump membrane protein; Provisional; Region: PRK15445 216592019190 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 216592019191 transmembrane helices; other site 216592019192 HMMPfam hit to PF02040, Arsenical pump membrane protein, score 0 216592019193 10 probable transmembrane helices predicted for EC042_3787 by TMHMM2.0 at aa 21-43, 48-70, 91-110, 114-131, 138-160, 175-197, 228-262, 277-296, 308-330 and 405-427 216592019194 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216592019195 ArsC family; Region: ArsC; pfam03960 216592019196 catalytic residues [active] 216592019197 HMMPfam hit to PF03960, ArsC family, score 2.6e-47 216592019198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592019199 dimerization interface [polypeptide binding]; other site 216592019200 putative DNA binding site [nucleotide binding]; other site 216592019201 putative Zn2+ binding site [ion binding]; other site 216592019202 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 0.00018 216592019203 Predicted helix-turn-helix motif with score 1321.000, SD 3.69 at aa 33-54, sequence LPVGELQKQLGIPGSTLSHHIS 216592019204 Predicted permeases [General function prediction only]; Region: COG0701 216592019205 HMMPfam hit to PF03773, Predicted permease, score 2.1e-37 216592019206 8 probable transmembrane helices predicted for EC042_3790 by TMHMM2.0 at aa 18-40, 60-82, 92-114, 121-140, 222-244, 251-268, 283-305 and 312-334 216592019207 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 216592019208 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019209 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 2.1e-100 216592019210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592019211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592019212 DNA binding residues [nucleotide binding] 216592019213 dimerization interface [polypeptide binding]; other site 216592019214 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 9.1e-06 216592019215 Predicted helix-turn-helix motif with score 1033.000, SD 2.71 at aa 131-152, sequence MTTEDILEKLKISLKTFYCHKH 216592019216 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 216592019217 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 216592019218 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 216592019219 HMMPfam hit to PF05171, Haemin-degrading family, score 7.7e-92 216592019220 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 216592019221 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592019222 N-terminal plug; other site 216592019223 ligand-binding site [chemical binding]; other site 216592019224 HMMPfam hit to PF00593, TonB dependent receptor, score 8.6e-25 216592019225 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.1e-30 216592019226 PS00430 TonB-dependent receptor proteins signature 1. 216592019227 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 216592019228 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 216592019229 putative hemin binding site; other site 216592019230 1 probable transmembrane helix predicted for EC042_3796 by TMHMM2.0 at aa 60-82 216592019231 HMMPfam hit to PF01497, Periplasmic binding protein, score 6.2e-72 216592019232 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 216592019233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592019234 FeS/SAM binding site; other site 216592019235 HMMPfam hit to PF04055, Radical SAM superfamily, score 7.8e-22 216592019236 HMMPfam hit to PF06969, HemN C-terminal region, score 6.4e-20 216592019237 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 216592019238 HMMPfam hit to PF06228, Protein of unknown function (DUF1008), score 2.8e-94 216592019239 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 216592019240 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216592019241 NAD(P) binding site [chemical binding]; other site 216592019242 putative active site [active] 216592019243 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216592019244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592019245 ABC-ATPase subunit interface; other site 216592019246 dimer interface [polypeptide binding]; other site 216592019247 putative PBP binding regions; other site 216592019248 8 probable transmembrane helices predicted for EC042_3800 by TMHMM2.0 at aa 12-31, 51-73, 85-107, 112-134, 146-168, 194-216, 237-259 and 305-324 216592019249 HMMPfam hit to PF01032, FecCD transport family, score 8.8e-119 216592019250 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 216592019251 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592019252 Walker A/P-loop; other site 216592019253 ATP binding site [chemical binding]; other site 216592019254 Q-loop/lid; other site 216592019255 ABC transporter signature motif; other site 216592019256 Walker B; other site 216592019257 D-loop; other site 216592019258 H-loop/switch region; other site 216592019259 HMMPfam hit to PF00005, ABC transporter, score 5.1e-44 216592019260 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019261 PS00211 ABC transporters family signature. 216592019262 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 216592019263 MgtC family; Region: MgtC; pfam02308 216592019264 HMMPfam hit to PF02308, MgtC family, score 1.6e-58 216592019265 4 probable transmembrane helices predicted for EC042_3802 by TMHMM2.0 at aa 7-29, 44-63, 68-90 and 94-116 216592019266 acid-resistance protein; Provisional; Region: hdeB; PRK11566 216592019267 acid-resistance protein; Provisional; Region: PRK10208 216592019268 HMMPfam hit to PF06411, hns-dependent expression protein A (HdeA), score 5.5e-64 216592019269 1 probable transmembrane helix predicted for EC042_3804 by TMHMM2.0 at aa 4-22 216592019270 acid-resistance membrane protein; Provisional; Region: PRK10209 216592019271 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 216592019272 6 probable transmembrane helices predicted for EC042_3805 by TMHMM2.0 at aa 26-44, 48-70, 77-99, 104-126, 139-161 and 165-187 216592019273 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216592019274 pyruvate kinase; Provisional; Region: PRK05826 216592019275 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 216592019276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592019277 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592019278 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019279 HMMPfam hit to PF00529, HlyD family secretion protein, score 8.8e-86 216592019280 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216592019281 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 216592019282 Protein export membrane protein; Region: SecD_SecF; cl14618 216592019283 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 0 216592019284 11 probable transmembrane helices predicted for EC042_3809 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 442-464, 474-496, 539-561, 871-890, 895-914, 924-946, 973-995 and 1005-1027 216592019285 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019286 transcriptional regulator YdeO; Provisional; Region: PRK09940 216592019287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592019288 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-14 216592019289 PS00041 Bacterial regulatory proteins, araC family signature. 216592019290 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.11 216592019291 Predicted helix-turn-helix motif with score 1282.000, SD 3.55 at aa 153-174, sequence WYLRDIAERMYTSESLIKKKLQ 216592019292 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 216592019293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592019294 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.1e-12 216592019295 PS00041 Bacterial regulatory proteins, araC family signature. 216592019296 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-06 216592019297 Predicted helix-turn-helix motif with score 1169.000, SD 3.17 at aa 159-180, sequence WTLARIASELLMSPSLLKKKLR 216592019298 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 216592019299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592019300 catalytic residue [active] 216592019301 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 1.9e-175 216592019302 PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 216592019303 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216592019304 Haem-binding domain; Region: Haem_bd; pfam14376 216592019305 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 216592019306 HMMPfam hit to PF00034, Cytochrome c, score 0.045 216592019307 PS00190 Cytochrome c family heme-binding site signature. 216592019308 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 2.2e-118 216592019309 PS00190 Cytochrome c family heme-binding site signature. 216592019310 PS00190 Cytochrome c family heme-binding site signature. 216592019311 1 probable transmembrane helix predicted for EC042_3813 by TMHMM2.0 at aa 7-29 216592019312 trehalase; Provisional; Region: treF; PRK13270 216592019313 Trehalase; Region: Trehalase; pfam01204 216592019314 HMMPfam hit to PF01204, Trehalase, score 2.4e-265 216592019315 PS00927 Trehalase signature 1. 216592019316 PS00928 Trehalase signature 2. 216592019317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592019318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592019319 DNA binding residues [nucleotide binding] 216592019320 dimerization interface [polypeptide binding]; other site 216592019321 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 1.3e-25 216592019322 PS00622 Bacterial regulatory proteins, luxR family signature. 216592019323 Predicted helix-turn-helix motif with score 1490.000, SD 4.26 at aa 157-178, sequence ESNKEIGRALNISTGTVKAHLE 216592019324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592019325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592019326 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 216592019327 putative effector binding pocket; other site 216592019328 putative dimerization interface [polypeptide binding]; other site 216592019329 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.3e-15 216592019330 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 41-62, sequence ESFSRAADFFALPKGSVSRQIQ 216592019331 PS00044 Bacterial regulatory proteins, lysR family signature. 216592019332 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.5e-45 216592019333 inner membrane protein YhjD; Region: TIGR00766 216592019334 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 2.4e-31 216592019335 6 probable transmembrane helices predicted for EC042_3817 by TMHMM2.0 at aa 75-97, 134-156, 186-208, 228-250, 262-284 and 299-321 216592019336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592019337 metabolite-proton symporter; Region: 2A0106; TIGR00883 216592019338 putative substrate translocation pore; other site 216592019339 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.1e-98 216592019340 11 probable transmembrane helices predicted for EC042_3818 by TMHMM2.0 at aa 24-46, 66-88, 109-131, 166-188, 195-217, 247-269, 290-312, 322-341, 346-368, 383-405 and 410-432 216592019341 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.9e-20 216592019342 PS00359 Ribosomal protein L11 signature. 216592019343 PS00216 Sugar transport proteins signature 1. 216592019344 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 216592019345 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216592019346 HMMPfam hit to PF05170, AsmA family, score 0 216592019347 1 probable transmembrane helix predicted for EC042_3819 by TMHMM2.0 at aa 12-34 216592019348 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592019349 HMMPfam hit to PF00563, EAL domain, score 2.1e-48 216592019350 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592019351 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216592019352 substrate binding site [chemical binding]; other site 216592019353 ATP binding site [chemical binding]; other site 216592019354 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.1e-85 216592019355 PS00584 pfkB family of carbohydrate kinases signature 2. 216592019356 1 probable transmembrane helix predicted for EC042_3822 by TMHMM2.0 at aa 7-29 216592019357 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019358 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216592019359 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216592019360 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 2.8e-25 216592019361 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 0.0034 216592019362 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 216592019363 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216592019364 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 5.6e-218 216592019365 8 probable transmembrane helices predicted for EC042_3828 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 219-241, 326-348 and 352-374 216592019366 PS00714 Sodium:dicarboxylate symporter family signature 2. 216592019367 PS00713 Sodium:dicarboxylate symporter family signature 1. 216592019368 putative diguanylate cyclase; Provisional; Region: PRK13561 216592019369 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216592019370 metal binding site [ion binding]; metal-binding site 216592019371 active site 216592019372 I-site; other site 216592019373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592019374 HMMPfam hit to PF00563, EAL domain, score 4.4e-109 216592019375 HMMPfam hit to PF00990, GGDEF domain, score 2.4e-07 216592019376 HMMPfam hit to PF00672, HAMP domain, score 1.2e-08 216592019377 2 probable transmembrane helices predicted for EC042_3829 by TMHMM2.0 at aa 5-24 and 145-167 216592019378 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 216592019379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592019380 binding surface 216592019381 TPR motif; other site 216592019382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592019383 binding surface 216592019384 TPR motif; other site 216592019385 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 216592019386 HMMPfam hit to PF05420, Cellulose synthase operon protein C C-termin, score 1.2e-196 216592019387 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.6 216592019388 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.3 216592019389 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.03 216592019390 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.56 216592019391 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 2e-06 216592019392 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.62 216592019393 endo-1,4-D-glucanase; Provisional; Region: PRK11097 216592019394 HMMPfam hit to PF01270, Glycosyl hydrolases family, score 2.9e-179 216592019395 PS00812 Glycosyl hydrolases family 8 signature. 216592019396 cellulose synthase regulator protein; Provisional; Region: PRK11114 216592019397 2 probable transmembrane helices predicted for EC042_3832 by TMHMM2.0 at aa 34-56 and 770-792 216592019398 HMMPfam hit to PF03170, Bacterial cellulose synthase subunit, score 0 216592019399 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 216592019400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216592019401 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 216592019402 DXD motif; other site 216592019403 PilZ domain; Region: PilZ; pfam07238 216592019404 PS00047 Histone H4 signature. 216592019405 10 probable transmembrane helices predicted for EC042_3833 by TMHMM2.0 at aa 28-50, 150-169, 173-190, 197-216, 229-251, 522-541, 545-567, 588-610, 633-655 and 668-690 216592019406 HMMPfam hit to PF00535, Glycosyl transferase, score 1.2e-23 216592019407 PS00215 Mitochondrial energy transfer proteins signature. 216592019408 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019409 cell division protein; Provisional; Region: PRK10037 216592019410 HMMPfam hit to PF06564, YhjQ protein, score 2.5e-155 216592019411 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 216592019412 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 216592019413 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 216592019414 PS00228 Tubulin-beta mRNA autoregulation signal. 216592019415 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 216592019416 1 probable transmembrane helix predicted for EC042_3837 by TMHMM2.0 at aa 7-29 216592019417 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 216592019418 4 probable transmembrane helices predicted for EC042_3838 by TMHMM2.0 at aa 33-55, 68-85, 114-133 and 140-162 216592019419 repetitive region 216592019420 putative antisense RNA 216592019421 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592019422 putative antisense RNA 216592019423 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592019424 putative antisense RNA 216592019425 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592019426 putative antisense RNA 216592019427 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592019428 putative antisense RNA 216592019429 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 216592019430 putative antisense RNA 216592019431 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216592019432 serine transporter; Region: stp; TIGR00814 216592019433 11 probable transmembrane helices predicted for EC042_3845 by TMHMM2.0 at aa 41-63, 68-85, 116-138, 158-180, 187-209, 224-246, 267-289, 318-340, 361-383, 389-411 and 424-443 216592019434 PS00307 Legume lectins beta-chain signature. 216592019435 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 216592019436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592019437 Walker A/P-loop; other site 216592019438 ATP binding site [chemical binding]; other site 216592019439 Q-loop/lid; other site 216592019440 ABC transporter signature motif; other site 216592019441 Walker B; other site 216592019442 D-loop; other site 216592019443 H-loop/switch region; other site 216592019444 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216592019445 HMMPfam hit to PF00005, ABC transporter, score 1e-61 216592019446 PS00211 ABC transporters family signature. 216592019447 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019448 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 216592019449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592019450 Walker A/P-loop; other site 216592019451 ATP binding site [chemical binding]; other site 216592019452 Q-loop/lid; other site 216592019453 ABC transporter signature motif; other site 216592019454 Walker B; other site 216592019455 D-loop; other site 216592019456 H-loop/switch region; other site 216592019457 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216592019458 HMMPfam hit to PF00005, ABC transporter, score 1.2e-59 216592019459 PS00211 ABC transporters family signature. 216592019460 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019461 dipeptide transporter; Provisional; Region: PRK10913 216592019462 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216592019463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592019464 dimer interface [polypeptide binding]; other site 216592019465 conserved gate region; other site 216592019466 putative PBP binding loops; other site 216592019467 ABC-ATPase subunit interface; other site 216592019468 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 9.3e-47 216592019469 5 probable transmembrane helices predicted for EC042_3848 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 216592019470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216592019471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592019472 dimer interface [polypeptide binding]; other site 216592019473 conserved gate region; other site 216592019474 putative PBP binding loops; other site 216592019475 ABC-ATPase subunit interface; other site 216592019476 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-55 216592019477 6 probable transmembrane helices predicted for EC042_3849 by TMHMM2.0 at aa 61-83, 151-173, 186-208, 254-273, 310-332 and 361-383 216592019478 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592019479 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592019480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216592019481 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216592019482 peptide binding site [polypeptide binding]; other site 216592019483 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.7e-101 216592019484 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216592019486 phosphoethanolamine transferase; Provisional; Region: PRK11560 216592019487 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 216592019488 Sulfatase; Region: Sulfatase; pfam00884 216592019489 HMMPfam hit to PF00884, Sulfatase, score 7.9e-98 216592019490 5 probable transmembrane helices predicted for EC042_3852 by TMHMM2.0 at aa 23-42, 57-79, 92-114, 129-151 and 172-189 216592019491 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 216592019492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592019493 putative substrate translocation pore; other site 216592019494 12 probable transmembrane helices predicted for EC042_3853 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 100-122, 135-154, 169-186, 217-236, 251-273, 280-302, 307-329, 342-364 and 368-387 216592019495 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.7e-35 216592019496 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 216592019497 1 probable transmembrane helix predicted for EC042_3854 by TMHMM2.0 at aa 12-34 216592019498 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 216592019499 HMMPfam hit to PF03352, Methyladenine glycosylase, score 1.1e-137 216592019500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216592019501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592019502 Coenzyme A binding pocket [chemical binding]; other site 216592019503 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.5e-18 216592019504 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 216592019505 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 216592019506 molybdopterin cofactor binding site [chemical binding]; other site 216592019507 substrate binding site [chemical binding]; other site 216592019508 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 216592019509 molybdopterin cofactor binding site; other site 216592019510 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 5.7e-48 216592019511 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592019512 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019513 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.1e-194 216592019514 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592019515 putative outer membrane lipoprotein; Provisional; Region: PRK10510 216592019516 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592019517 ligand binding site [chemical binding]; other site 216592019518 3 probable transmembrane helices predicted for EC042_3858 by TMHMM2.0 at aa 5-27, 37-55 and 62-84 216592019519 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019520 HMMPfam hit to PF00691, OmpA family, score 1.7e-47 216592019521 PS01068 OmpA-like domain. 216592019522 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 216592019523 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 216592019524 dimerization interface [polypeptide binding]; other site 216592019525 ligand binding site [chemical binding]; other site 216592019526 NADP binding site [chemical binding]; other site 216592019527 catalytic site [active] 216592019528 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 1.1e-22 216592019529 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.5e-97 216592019530 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216592019531 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216592019532 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 216592019533 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019534 Predicted transcriptional regulator [Transcription]; Region: COG2944 216592019535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592019536 non-specific DNA binding site [nucleotide binding]; other site 216592019537 salt bridge; other site 216592019538 sequence-specific DNA binding site [nucleotide binding]; other site 216592019539 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 47-68, sequence LKIDDFARVLGVSVAMVKEWES 216592019540 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216592019541 DNA-binding site [nucleotide binding]; DNA binding site 216592019542 RNA-binding motif; other site 216592019543 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.9e-44 216592019544 PS00352 'Cold-shock' DNA-binding domain signature. 216592019545 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 216592019546 DALR anticodon binding domain; Region: DALR_1; pfam05746 216592019547 anticodon binding site; other site 216592019548 tRNA binding surface [nucleotide binding]; other site 216592019549 HMMPfam hit to PF05746, DALR anticodon binding domain, score 1.5e-05 216592019550 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 216592019551 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 216592019552 dimer interface [polypeptide binding]; other site 216592019553 motif 1; other site 216592019554 active site 216592019555 motif 2; other site 216592019556 motif 3; other site 216592019557 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 1.3e-249 216592019558 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592019559 YsaB-like lipoprotein; Region: YsaB; pfam13983 216592019560 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019561 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 216592019562 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216592019563 HMMPfam hit to PF01757, Acyltransferase family, score 0.00033 216592019564 10 probable transmembrane helices predicted for EC042_3867 by TMHMM2.0 at aa 13-30, 45-67, 79-101, 114-136, 143-160, 170-189, 202-224, 234-256, 269-288 and 298-320 216592019565 hypothetical protein; Provisional; Region: PRK11383 216592019566 yiaA/B two helix domain; Region: YiaAB; pfam05360 216592019567 yiaA/B two helix domain; Region: YiaAB; pfam05360 216592019568 HMMPfam hit to PF05360, yiaA/B two helix domain, score 9e-21 216592019569 4 probable transmembrane helices predicted for EC042_3868 by TMHMM2.0 at aa 13-33, 43-60, 73-95 and 100-122 216592019570 HMMPfam hit to PF05360, yiaA/B two helix domain, score 5.5e-22 216592019571 hypothetical protein; Provisional; Region: PRK11403 216592019572 yiaA/B two helix domain; Region: YiaAB; pfam05360 216592019573 HMMPfam hit to PF05360, yiaA/B two helix domain, score 1.9e-16 216592019574 4 probable transmembrane helices predicted for EC042_3869 by TMHMM2.0 at aa 7-29, 34-51, 63-82 and 92-110 216592019575 HMMPfam hit to PF05360, yiaA/B two helix domain, score 4.3e-19 216592019576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019577 xylulokinase; Provisional; Region: PRK15027 216592019578 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 216592019579 N- and C-terminal domain interface [polypeptide binding]; other site 216592019580 active site 216592019581 MgATP binding site [chemical binding]; other site 216592019582 catalytic site [active] 216592019583 metal binding site [ion binding]; metal-binding site 216592019584 xylulose binding site [chemical binding]; other site 216592019585 homodimer interface [polypeptide binding]; other site 216592019586 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 7.3e-108 216592019587 PS00445 FGGY family of carbohydrate kinases signature 2. 216592019588 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 2.4e-132 216592019589 PS00933 FGGY family of carbohydrate kinases signature 1. 216592019590 xylose isomerase; Provisional; Region: PRK05474 216592019591 xylose isomerase; Region: xylose_isom_A; TIGR02630 216592019592 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 2e-09 216592019593 PS00172 Xylose isomerase signature 1. 216592019594 PS00173 Xylose isomerase signature 2. 216592019595 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 216592019596 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 216592019597 putative ligand binding site [chemical binding]; other site 216592019598 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 8.9e-06 216592019599 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 216592019600 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592019601 Walker A/P-loop; other site 216592019602 ATP binding site [chemical binding]; other site 216592019603 Q-loop/lid; other site 216592019604 ABC transporter signature motif; other site 216592019605 Walker B; other site 216592019606 D-loop; other site 216592019607 H-loop/switch region; other site 216592019608 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592019609 HMMPfam hit to PF00005, ABC transporter, score 2.8e-47 216592019610 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019611 HMMPfam hit to PF00005, ABC transporter, score 2.6e-29 216592019612 PS00211 ABC transporters family signature. 216592019613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592019614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592019615 TM-ABC transporter signature motif; other site 216592019616 10 probable transmembrane helices predicted for EC042_3874 by TMHMM2.0 at aa 24-46, 61-80, 85-107, 111-133, 140-162, 177-196, 216-235, 240-259, 331-353 and 368-385 216592019617 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.4e-62 216592019619 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 4.1e-11 216592019620 PS00041 Bacterial regulatory proteins, araC family signature. 216592019621 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 5.5e-15 216592019622 hypothetical protein; Provisional; Region: PRK10356 216592019623 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 216592019624 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglu, score 4.4e-51 216592019625 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019626 alpha-amylase; Reviewed; Region: malS; PRK09505 216592019627 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 216592019628 active site 216592019629 catalytic site [active] 216592019630 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 5.6e-99 216592019631 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 216592019632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592019633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592019634 homodimer interface [polypeptide binding]; other site 216592019635 catalytic residue [active] 216592019636 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 216592019637 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.8e-07 216592019638 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592019639 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.01 216592019640 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216592019641 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216592019642 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592019643 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 3.8e-94 216592019644 PS01051 Bacterial regulatory proteins, iclR family signature. 216592019645 Predicted helix-turn-helix motif with score 1737.000, SD 5.10 at aa 43-64, sequence CPLAHLSELAGLNKSTVHRLLQ 216592019646 Partial present in Uropathogenic, absent in 0157, misc. carbohydrate catabolism (regulator, transporter, enzymes including: 3-keto-L-gulonate 6-phosphate decarboxylase, 3-epimerase, L-xylulose kinase) 216592019647 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 216592019648 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 4.8e-211 216592019649 Domain of unknown function (DUF386); Region: DUF386; pfam04074 216592019650 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 2.2e-80 216592019651 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 216592019652 4 probable transmembrane helices predicted for EC042_3883 by TMHMM2.0 at aa 7-29, 44-66, 79-98 and 113-135 216592019653 HMMPfam hit to PF04290, Tripartite ATP-independent periplasmic trans, score 5.4e-48 216592019654 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 216592019655 DctM-like transporters; Region: DctM; pfam06808 216592019656 11 probable transmembrane helices predicted for EC042_3884 by TMHMM2.0 at aa 4-26, 47-69, 102-124, 137-159, 169-191, 211-230, 234-256, 277-299, 314-343, 355-377 and 397-419 216592019657 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport (Dct) system, score 1.3e-36 216592019658 HMMPfam hit to PF00597, DedA family, score 9e-63 216592019659 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 216592019660 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 216592019661 HMMPfam hit to PF03480, Bacterial extracellular solute-binding prot, score 1.1e-133 216592019662 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216592019663 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 216592019664 putative N- and C-terminal domain interface [polypeptide binding]; other site 216592019665 putative active site [active] 216592019666 MgATP binding site [chemical binding]; other site 216592019667 catalytic site [active] 216592019668 metal binding site [ion binding]; metal-binding site 216592019669 putative xylulose binding site [chemical binding]; other site 216592019670 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 2.1e-138 216592019671 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 2.9e-105 216592019672 PS00445 FGGY family of carbohydrate kinases signature 2. 216592019673 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 216592019674 active site 216592019675 dimer interface [polypeptide binding]; other site 216592019676 magnesium binding site [ion binding]; other site 216592019677 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 8e-57 216592019678 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 216592019679 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 216592019680 AP (apurinic/apyrimidinic) site pocket; other site 216592019681 DNA interaction; other site 216592019682 Metal-binding active site; metal-binding site 216592019683 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 3.3e-46 216592019684 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 216592019685 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 216592019686 intersubunit interface [polypeptide binding]; other site 216592019687 active site 216592019688 Zn2+ binding site [ion binding]; other site 216592019689 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 2.2e-98 216592019690 Present in 0157, absent in UPEC, EPEC and EPEC. misc transport islet (regulators, transporter 216592019691 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216592019692 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216592019693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592019694 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 1.5e-08 216592019695 PS00041 Bacterial regulatory proteins, araC family signature. 216592019696 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 0.022 216592019697 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 3e-21 216592019698 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 216592019699 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 216592019700 12 probable transmembrane helices predicted for EC042_3891 by TMHMM2.0 at aa 26-48, 53-75, 96-113, 123-145, 164-186, 196-218, 245-267, 277-299, 311-328, 338-360, 381-403 and 423-445 216592019701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 216592019702 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 216592019703 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 216592019704 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 3.3e-100 216592019705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216592019706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592019707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216592019708 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-14 216592019709 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 21-42, sequence ENISHAATVLGIAQANVSKYLA 216592019710 PS00044 Bacterial regulatory proteins, lysR family signature. 216592019711 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.4e-05 216592019712 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216592019713 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592019714 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592019715 HMMPfam hit to PF00529, HlyD family secretion protein, score 1e-66 216592019716 2 probable transmembrane helices predicted for EC042_3895 by TMHMM2.0 at aa 3-17 and 27-49 216592019717 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 216592019718 FlxA-like protein; Region: FlxA; pfam14282 216592019719 2 probable transmembrane helices predicted for EC042_3896 by TMHMM2.0 at aa 7-29 and 44-66 216592019720 1 probable transmembrane helix predicted for EC042_3897 by TMHMM2.0 at aa 42-64 216592019721 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 216592019722 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216592019723 NAD(P) binding site [chemical binding]; other site 216592019724 catalytic residues [active] 216592019725 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 2.7e-249 216592019726 PS00070 Aldehyde dehydrogenases cysteine active site. 216592019727 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592019728 Fic family protein [Function unknown]; Region: COG3177 216592019729 Fic/DOC family; Region: Fic; pfam02661 216592019730 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216592019731 HMMPfam hit to PF02661, Fic protein family, score 5.9e-21 216592019732 putative alcohol dehydrogenase; Provisional; Region: PRK09860 216592019733 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 216592019734 dimer interface [polypeptide binding]; other site 216592019735 active site 216592019736 metal binding site [ion binding]; metal-binding site 216592019737 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.8e-229 216592019738 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592019739 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592019740 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 216592019741 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 216592019742 G1 box; other site 216592019743 putative GEF interaction site [polypeptide binding]; other site 216592019744 GTP/Mg2+ binding site [chemical binding]; other site 216592019745 Switch I region; other site 216592019746 G2 box; other site 216592019747 G3 box; other site 216592019748 Switch II region; other site 216592019749 G4 box; other site 216592019750 G5 box; other site 216592019751 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 216592019752 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 216592019753 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 216592019754 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 216592019755 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.5e-12 216592019756 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.9e-39 216592019757 PS00301 GTP-binding elongation factors signature. 216592019758 PS00017 ATP/GTP-binding site motif A (P-loop). 216592019759 selenocysteine synthase; Provisional; Region: PRK04311 216592019760 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 216592019761 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 216592019762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592019763 catalytic residue [active] 216592019764 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 2.6e-259 216592019765 putative glutathione S-transferase; Provisional; Region: PRK10357 216592019766 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 216592019767 putative C-terminal domain interface [polypeptide binding]; other site 216592019768 putative GSH binding site (G-site) [chemical binding]; other site 216592019769 putative dimer interface [polypeptide binding]; other site 216592019770 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 216592019771 dimer interface [polypeptide binding]; other site 216592019772 N-terminal domain interface [polypeptide binding]; other site 216592019773 putative substrate binding pocket (H-site) [chemical binding]; other site 216592019774 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 6.5e-20 216592019775 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.6e-16 216592019776 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216592019777 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592019778 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592019779 HMMPfam hit to PF00529, HlyD family secretion protein, score 7.1e-68 216592019780 2 probable transmembrane helices predicted for EC042_3904 by TMHMM2.0 at aa 5-22 and 27-49 216592019781 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 216592019782 2 probable transmembrane helices predicted for EC042_3905 by TMHMM2.0 at aa 2-24 and 44-66 216592019783 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 216592019784 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 216592019785 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 216592019786 active site 216592019787 P-loop; other site 216592019788 phosphorylation site [posttranslational modification] 216592019789 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592019790 active site 216592019791 phosphorylation site [posttranslational modification] 216592019792 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.8e-25 216592019793 8 probable transmembrane helices predicted for EC042_3906 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151, 212-234, 244-263, 270-292 and 312-334 216592019794 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific II, score 4.1e-14 216592019795 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 8.4e-84 216592019796 PS00372 PTS EIIA domains phosphorylation site signature 2. 216592019797 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 216592019798 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216592019799 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216592019800 HMMPfam hit to PF01232, Mannitol dehydrogenase, score 8e-186 216592019801 PS00974 Mannitol dehydrogenases signature. 216592019802 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 216592019803 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 216592019804 HMMPfam hit to PF05068, Mannitol repressor, score 6.7e-135 216592019805 hypothetical protein; Provisional; Region: PRK11020 216592019806 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 216592019807 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592019808 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592019809 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 216592019810 trimer interface [polypeptide binding]; other site 216592019811 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 216592019812 trimer interface [polypeptide binding]; other site 216592019813 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 216592019814 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 216592019815 trimer interface [polypeptide binding]; other site 216592019816 Haemagglutinin; Region: HIM; pfam05662 216592019817 Haemagglutinin; Region: HIM; pfam05662 216592019818 YadA-like C-terminal region; Region: YadA; pfam03895 216592019819 HMMPfam hit to PF05658, Hep_Hag, score 0.00049 216592019820 HMMPfam hit to PF05658, Hep_Hag, score 5e-05 216592019821 HMMPfam hit to PF05658, Hep_Hag, score 0.003 216592019822 HMMPfam hit to PF05658, Hep_Hag, score 0.0014 216592019823 HMMPfam hit to PF05658, Hep_Hag, score 0.00086 216592019824 HMMPfam hit to PF05658, Hep_Hag, score 0.0006 216592019825 HMMPfam hit to PF05658, Hep_Hag, score 9.3e-07 216592019826 HMMPfam hit to PF05658, Hep_Hag, score 4.1e-05 216592019827 HMMPfam hit to PF05658, Hep_Hag, score 0.0033 216592019828 HMMPfam hit to PF05658, Hep_Hag, score 0.0085 216592019829 HMMPfam hit to PF05662, Haemagglutinin, score 4.1e-08 216592019830 HMMPfam hit to PF05662, Haemagglutinin, score 5.2e-06 216592019831 HMMPfam hit to PF05662, Haemagglutinin, score 4.6e-07 216592019832 HMMPfam hit to PF05662, Haemagglutinin, score 4.6e-07 216592019833 HMMPfam hit to PF05662, Haemagglutinin, score 2.1e-06 216592019834 HMMPfam hit to PF05662, Haemagglutinin, score 4.6e-07 216592019835 HMMPfam hit to PF05662, Haemagglutinin, score 7.1e-05 216592019836 HMMPfam hit to PF05662, Haemagglutinin, score 3.2e-05 216592019837 HMMPfam hit to PF05662, Haemagglutinin, score 8e-06 216592019838 HMMPfam hit to PF05662, Haemagglutinin, score 0.00031 216592019839 HMMPfam hit to PF05658, Hep_Hag, score 1.1e-05 216592019840 HMMPfam hit to PF05662, Haemagglutinin, score 3.2e-06 216592019841 HMMPfam hit to PF05658, Hep_Hag, score 0.00013 216592019842 HMMPfam hit to PF05658, Hep_Hag, score 4.5e-05 216592019843 HMMPfam hit to PF05662, Haemagglutinin, score 7.8e-08 216592019844 HMMPfam hit to PF05658, Hep_Hag, score 2 216592019845 HMMPfam hit to PF05658, Hep_Hag, score 0.00017 216592019846 HMMPfam hit to PF05662, Haemagglutinin, score 3.4e-09 216592019847 HMMPfam hit to PF05662, Haemagglutinin, score 2.1e-06 216592019848 HMMPfam hit to PF03895, YadA-like C-terminal region, score 5.9e-36 216592019849 L-lactate permease; Provisional; Region: PRK10420 216592019850 glycolate transporter; Provisional; Region: PRK09695 216592019851 12 probable transmembrane helices predicted for EC042_3913 by TMHMM2.0 at aa 10-32, 39-58, 68-90, 119-141, 161-183, 195-217, 244-266, 368-387, 407-426, 433-455, 498-515 and 528-550 216592019852 HMMPfam hit to PF02652, L-lactate permease, score 0 216592019853 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 216592019854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592019855 DNA-binding site [nucleotide binding]; DNA binding site 216592019856 FCD domain; Region: FCD; pfam07729 216592019857 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.8e-27 216592019858 PS00043 Bacterial regulatory proteins, gntR family signature. 216592019859 HMMPfam hit to PF07729, FCD domain, score 8.9e-41 216592019860 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 216592019861 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216592019862 phosphate binding site [ion binding]; other site 216592019863 HMMPfam hit to PF01070, FMN-dependent dehydrogenase, score 4.2e-235 216592019864 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 216592019865 putative rRNA methylase; Provisional; Region: PRK10358 216592019866 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.5e-62 216592019867 serine acetyltransferase; Provisional; Region: cysE; PRK11132 216592019868 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 216592019869 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216592019870 trimer interface [polypeptide binding]; other site 216592019871 active site 216592019872 substrate binding site [chemical binding]; other site 216592019873 CoA binding site [chemical binding]; other site 216592019874 PS00101 Hexapeptide-repeat containing-transferases signature. 216592019875 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2 216592019876 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 8.8 216592019877 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 216592019878 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 2.8e-66 216592019879 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 216592019880 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216592019881 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216592019882 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 6.9e-84 216592019883 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 216592019884 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 6.2e-82 216592019885 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 216592019886 SecA binding site; other site 216592019887 Preprotein binding site; other site 216592019888 HMMPfam hit to PF02556, Preprotein translocase subunit SecB, score 4.5e-102 216592019889 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 216592019890 GSH binding site [chemical binding]; other site 216592019891 catalytic residues [active] 216592019892 HMMPfam hit to PF00462, Glutaredoxin, score 2.7e-34 216592019893 PS00195 Glutaredoxin active site. 216592019894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216592019895 active site residue [active] 216592019896 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.1e-22 216592019897 1 probable transmembrane helix predicted for EC042_3921 by TMHMM2.0 at aa 15-37 216592019898 phosphoglyceromutase; Provisional; Region: PRK05434 216592019899 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 216592019900 HMMPfam hit to PF06415, BPG-independent PGAM N-terminus (iPGM_N, score 1.2e-254 216592019901 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 9.1e-56 216592019902 AmiB activator; Provisional; Region: PRK11637 216592019903 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 216592019904 Peptidase family M23; Region: Peptidase_M23; pfam01551 216592019905 1 probable transmembrane helix predicted for EC042_3923 by TMHMM2.0 at aa 12-34 216592019906 HMMPfam hit to PF01551, Peptidase family M23, score 2.1e-40 216592019907 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 216592019908 NodB motif; other site 216592019909 putative active site [active] 216592019910 putative catalytic site [active] 216592019911 Zn binding site [ion binding]; other site 216592019912 1 probable transmembrane helix predicted for EC042_3924 by TMHMM2.0 at aa 7-29 216592019913 HMMPfam hit to PF04748, Divergent polysaccharide deacetylase, score 6.4e-126 216592019914 putative glycosyl transferase; Provisional; Region: PRK10073 216592019915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216592019916 active site 216592019917 HMMPfam hit to PF00535, Glycosyl transferase, score 1.5e-41 216592019918 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 216592019919 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216592019920 NAD(P) binding site [chemical binding]; other site 216592019921 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.6e-110 216592019922 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592019923 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216592019924 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216592019925 substrate-cofactor binding pocket; other site 216592019926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592019927 catalytic residue [active] 216592019928 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2e-81 216592019929 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216592019930 hypothetical protein; Provisional; Region: PRK11346 216592019931 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 216592019932 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 216592019933 NADP binding site [chemical binding]; other site 216592019934 homopentamer interface [polypeptide binding]; other site 216592019935 substrate binding site [chemical binding]; other site 216592019936 active site 216592019937 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9.8e-13 216592019938 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216592019939 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216592019940 putative active site [active] 216592019941 HMMPfam hit to PF01075, Glycosyltransferase family, score 2.2e-127 216592019942 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216592019943 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216592019944 putative active site [active] 216592019945 HMMPfam hit to PF01075, Glycosyltransferase family, score 1.6e-117 216592019946 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 216592019947 O-antigen ligase RfaL; Provisional; Region: PRK15487 216592019948 Present in 0157, divergent in Uropathogenic, LPS biosynthetesis genes, orthologous replacement 216592019949 11 probable transmembrane helices predicted for EC042_3932 by TMHMM2.0 at aa 13-35, 40-55, 62-84, 97-116, 128-146, 166-183, 190-207, 211-226, 231-248, 323-345 and 358-377 216592019950 HMMPfam hit to PF04932, O-Antigen Polymerase, score 5.9e-19 216592019951 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 216592019952 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216592019953 HMMPfam hit to PF00534, Glycosyl transferases group, score 2.2e-49 216592019954 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 216592019955 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 216592019956 Ligand binding site; other site 216592019957 metal-binding site 216592019958 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 216592019959 HMMPfam hit to PF01501, Glycosyl transferase family, score 1.2e-68 216592019960 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 216592019961 HMMPfam hit to PF06176, Lipopolysaccharide core biosynthesis protein, score 1.3e-185 216592019962 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 216592019963 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 216592019964 Ligand binding site; other site 216592019965 metal-binding site 216592019966 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 216592019967 HMMPfam hit to PF01501, Glycosyl transferase family, score 1.7e-89 216592019968 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 216592019969 HMMPfam hit to PF06293, Lipopolysaccharide kinase (Kdo/WaaP) family, score 6.1e-102 216592019970 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216592019971 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216592019972 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.3e-39 216592019973 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592019974 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 216592019975 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216592019976 putative active site [active] 216592019977 HMMPfam hit to PF01075, Glycosyltransferase family, score 1.2e-77 216592019978 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 216592019979 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 216592019980 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216592019981 HMMPfam hit to PF04413, 3-Deoxy-D-manno-octulosonic-acid tran, score 4.8e-120 216592019982 HMMPfam hit to PF00534, Glycosyl transferases group, score 3.4e-05 216592019983 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 216592019984 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 216592019985 active site 216592019986 (T/H)XGH motif; other site 216592019987 HMMPfam hit to PF01467, Cytidylyltransferase, score 3.9e-42 216592019988 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 216592019989 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 216592019990 DNA binding site [nucleotide binding] 216592019991 catalytic residue [active] 216592019992 H2TH interface [polypeptide binding]; other site 216592019993 putative catalytic residues [active] 216592019994 turnover-facilitating residue; other site 216592019995 intercalation triad [nucleotide binding]; other site 216592019996 8OG recognition residue [nucleotide binding]; other site 216592019997 putative reading head residues; other site 216592019998 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216592019999 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216592020000 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 0.012 216592020001 PS01242 Formamidopyrimidine-DNA glycosylase signature. 216592020002 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycosylase H2, score 2.9e-53 216592020003 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 1.5e-62 216592020004 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 216592020005 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 216592020006 HMMPfam hit to PF00830, Ribosomal L28 family, score 6.3e-36 216592020007 hypothetical protein; Reviewed; Region: PRK00024 216592020008 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216592020009 MPN+ (JAMM) motif; other site 216592020010 Zinc-binding site [ion binding]; other site 216592020011 HMMPfam hit to PF04002, RadC, DNA repair protein, score 4.6e-83 216592020012 PS01302 DNA repair protein radC family signature. 216592020013 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 216592020014 Flavoprotein; Region: Flavoprotein; pfam02441 216592020015 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 216592020016 HMMPfam hit to PF02441, Flavoprotein, score 3.8e-47 216592020017 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 4.8e-40 216592020018 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216592020019 trimer interface [polypeptide binding]; other site 216592020020 active site 216592020021 HMMPfam hit to PF00692, dUTPase, score 2.5e-57 216592020022 division inhibitor protein; Provisional; Region: slmA; PRK09480 216592020023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592020024 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.7e-10 216592020025 PS01081 Bacterial regulatory proteins, tetR family signature. 216592020026 Predicted helix-turn-helix motif with score 1937.000, SD 5.78 at aa 46-67, sequence ITTAKLAASVGVSEAALYRHFP 216592020027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216592020028 active site 216592020029 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 3e-33 216592020030 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216592020031 ribonuclease PH; Reviewed; Region: rph; PRK00173 216592020032 Ribonuclease PH; Region: RNase_PH_bact; cd11362 216592020033 hexamer interface [polypeptide binding]; other site 216592020034 active site 216592020035 HMMPfam hit to PF03725, 3' exoribonuclease family, domain, score 6.2e-24 216592020036 HMMPfam hit to PF01138, 3' exoribonuclease family, domain, score 3.9e-58 216592020037 PS01277 Ribonuclease PH signature. 216592020038 hypothetical protein; Provisional; Region: PRK11820 216592020039 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 216592020040 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 216592020041 HMMPfam hit to PF03755, YicC-like family, N-terminal region, score 1.7e-88 216592020042 prophage 7. Unique to 042 (hypothetical protein, prophage maintenance system killer protein) 216592020043 integrase; Provisional; Region: PRK09692 216592020044 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592020045 active site 216592020046 Int/Topo IB signature motif; other site 216592020047 HMMPfam hit to PF00589, Phage integrase family, score 2.7e-17 216592020048 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 216592020049 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 1.7e-09 216592020050 Predicted helix-turn-helix motif with score 1849.000, SD 5.48 at aa 12-33, sequence IRRFRLAELLGVSVSTIDRKVR 216592020051 AntA/AntB antirepressor; Region: AntA; pfam08346 216592020052 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020053 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592020054 Ash protein family; Region: Phage_ASH; pfam10554 216592020055 1 probable transmembrane helix predicted for EC042_3956 by TMHMM2.0 at aa 260-282 216592020056 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020057 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 216592020058 Kinase binding protein CGI-121; Region: CGI-121; cl00698 216592020059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 216592020060 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 216592020061 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 216592020062 active site 216592020063 metal binding site [ion binding]; metal-binding site 216592020064 interdomain interaction site; other site 216592020065 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 216592020066 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 216592020067 4 probable transmembrane helices predicted for EC042_3970 by TMHMM2.0 at aa 21-38, 48-67, 80-102 and 115-132 216592020068 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 216592020069 PerC transcriptional activator; Region: PerC; pfam06069 216592020070 Fic/DOC family; Region: Fic; cl00960 216592020071 HMMPfam hit to PF05012, Prophage maintenance system killer protein, score 1.8e-12 216592020072 Predicted helix-turn-helix motif with score 1283.000, SD 3.56 at aa 42-63, sequence FTKNQLVDLFDVSDATIERYIA 216592020073 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 216592020074 BRO family, N-terminal domain; Region: Bro-N; cl10591 216592020075 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592020076 Predicted membrane protein [Function unknown]; Region: COG2860 216592020077 UPF0126 domain; Region: UPF0126; pfam03458 216592020078 UPF0126 domain; Region: UPF0126; pfam03458 216592020079 6 probable transmembrane helices predicted for EC042_3978 by TMHMM2.0 at aa 21-40, 82-99, 106-127, 132-154, 166-185 and 190-207 216592020080 HMMPfam hit to PF03458, UPF0126 domain, score 8.7e-35 216592020081 HMMPfam hit to PF03458, UPF0126 domain, score 7.2e-39 216592020082 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 216592020083 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 216592020084 nucleotide binding pocket [chemical binding]; other site 216592020085 K-X-D-G motif; other site 216592020086 catalytic site [active] 216592020087 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216592020088 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592020089 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 6.8e-33 216592020090 PS01056 NAD-dependent DNA ligase signature 2. 216592020091 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 7.8e-72 216592020092 PS01055 NAD-dependent DNA ligase signature 1. 216592020093 2 probable transmembrane helices predicted for EC042_3980 by TMHMM2.0 at aa 20-39 and 52-69 216592020094 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 216592020095 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 216592020096 catalytic site [active] 216592020097 G-X2-G-X-G-K; other site 216592020098 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020099 PS00856 Guanylate kinase signature. 216592020100 HMMPfam hit to PF00625, Guanylate kinase, score 1.6e-63 216592020101 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 216592020102 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 3.4e-22 216592020103 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 216592020104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216592020105 Zn2+ binding site [ion binding]; other site 216592020106 Mg2+ binding site [ion binding]; other site 216592020107 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216592020108 synthetase active site [active] 216592020109 NTP binding site [chemical binding]; other site 216592020110 metal binding site [ion binding]; metal-binding site 216592020111 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 216592020112 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216592020113 HMMPfam hit to PF01966, HD domain, score 1.6e-19 216592020114 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 1.8e-45 216592020115 HMMPfam hit to PF02824, TGS domain, score 4.7e-30 216592020116 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 216592020117 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216592020118 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 216592020119 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 8.7e-62 216592020120 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 216592020121 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 216592020122 generic binding surface II; other site 216592020123 ssDNA binding site; other site 216592020124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592020125 ATP binding site [chemical binding]; other site 216592020126 putative Mg++ binding site [ion binding]; other site 216592020127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592020128 nucleotide binding region [chemical binding]; other site 216592020129 ATP-binding site [chemical binding]; other site 216592020130 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.1e-11 216592020131 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 3.6e-36 216592020132 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020133 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.4e-23 216592020134 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 216592020135 9 probable transmembrane helices predicted for EC042_3986 by TMHMM2.0 at aa 70-87, 94-116, 157-179, 215-237, 241-263, 270-292, 302-324, 336-358 and 368-390 216592020136 HMMPfam hit to PF03616, Sodium/glutamate symporter, score 3.4e-257 216592020137 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 216592020138 HMMPfam hit to PF00860, Permease family, score 7.7e-163 216592020139 11 probable transmembrane helices predicted for EC042_3987 by TMHMM2.0 at aa 43-65, 90-112, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458 216592020140 PS01116 Xanthine/uracil permeases family signature. 216592020141 AsmA family; Region: AsmA; pfam05170 216592020142 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216592020143 HMMPfam hit to PF07089, Protein of unknown function (DUF1354), score 0 216592020144 1 probable transmembrane helix predicted for EC042_3988 by TMHMM2.0 at aa 12-34 216592020145 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592020146 putative alpha-glucosidase; Provisional; Region: PRK10658 216592020147 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 216592020148 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 216592020149 active site 216592020150 homotrimer interface [polypeptide binding]; other site 216592020151 catalytic site [active] 216592020152 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 216592020153 HMMPfam hit to PF01055, Glycosyl hydrolases family, score 1.1e-178 216592020154 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 216592020155 putative transporter; Provisional; Region: PRK11462 216592020156 11 probable transmembrane helices predicted for EC042_3990 by TMHMM2.0 at aa 51-73, 100-119, 134-156, 169-189, 199-221, 251-273, 283-305, 312-334, 339-361, 382-404 and 419-441 216592020157 PS00872 Sodium:galactoside symporter family signature. 216592020158 prophage-like. Sequence divergence between 0157 and Uropathogenic strains (various phage proteins, amber mutation-suppressing protein, DNA primase), inserted at tRNA, flanked by repeats 216592020159 integrase; Provisional; Region: PRK09692 216592020160 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592020161 active site 216592020162 Int/Topo IB signature motif; other site 216592020163 HMMPfam hit to PF00589, Phage integrase family, score 8e-28 216592020164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592020165 AAA domain; Region: AAA_23; pfam13476 216592020166 Walker A/P-loop; other site 216592020167 ATP binding site [chemical binding]; other site 216592020168 AAA domain; Region: AAA_21; pfam13304 216592020169 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020170 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 216592020171 HMMPfam hit to PF07455, Phage polarity suppression protein (Psu), score 3.1e-132 216592020172 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 216592020173 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 216592020174 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 2.2e-31 216592020175 Predicted helix-turn-helix motif with score 1779.000, SD 5.25 at aa 28-49, sequence LRLPEVMHLCGLSRSTIYELIR 216592020176 Ash protein family; Region: Phage_ASH; pfam10554 216592020177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 216592020178 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 216592020179 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 216592020180 active site 216592020181 metal binding site [ion binding]; metal-binding site 216592020182 interdomain interaction site; other site 216592020183 D5 N terminal like; Region: D5_N; smart00885 216592020184 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 216592020185 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 216592020186 HMMPfam hit to PF01751, Toprim domain, score 3.3e-09 216592020187 HMMPfam hit to PF03288, Poxvirus D5 protein-like, score 3.2e-147 216592020188 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020189 sugar efflux transporter; Region: 2A0120; TIGR00899 216592020190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020191 putative substrate translocation pore; other site 216592020192 12 probable transmembrane helices predicted for EC042_4003 by TMHMM2.0 at aa 12-34, 49-71, 83-100, 104-121, 141-163, 173-195, 222-244, 254-276, 283-302, 312-331, 351-368 and 372-391 216592020193 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.7e-36 216592020194 EamA-like transporter family; Region: EamA; pfam00892 216592020195 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216592020196 EamA-like transporter family; Region: EamA; pfam00892 216592020197 10 probable transmembrane helices predicted for EC042_4004 by TMHMM2.0 at aa 7-29, 39-59, 72-94, 98-120, 127-144, 154-176, 183-205, 215-237, 250-272 and 276-293 216592020198 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.2e-18 216592020199 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1e-24 216592020200 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 216592020201 lipoprotein, YaeC family; Region: TIGR00363 216592020202 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.5e-136 216592020203 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592020204 1 probable transmembrane helix predicted for EC042_4006 by TMHMM2.0 at aa 21-43 216592020205 Unique to 042, pathogenicity island (homologues of salmonella invasin chaperone, sicA; cell invasion protein, SipB; cell invasion protein, SipD; transcriptional regulator, HilA; large repetative protein-possible invasin) 216592020206 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 216592020207 Tetratricopeptide repeat; Region: TPR_3; pfam07720 216592020208 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 3.1e-10 216592020209 HMMPfam hit to PF07720, Tetratricopeptide repeat, score 1.8e-06 216592020210 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 216592020211 3 probable transmembrane helices predicted for EC042_4008 by TMHMM2.0 at aa 314-336, 346-364 and 429-451 216592020212 1 probable transmembrane helix predicted for EC042_4009 by TMHMM2.0 at aa 174-196 216592020213 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 216592020214 invasion protein regulator; Provisional; Region: PRK12370 216592020215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592020216 DNA binding site [nucleotide binding] 216592020217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592020218 TPR motif; other site 216592020219 binding surface 216592020220 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 4e-16 216592020221 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.0013 216592020222 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 216592020223 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 216592020224 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020225 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020226 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020227 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020228 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020229 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020230 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020231 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020232 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020233 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020234 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020235 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020236 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020237 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020238 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020239 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020240 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020241 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020242 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020243 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020244 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 216592020245 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 3.1e-16 216592020246 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.2e-10 216592020247 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 3.4e-11 216592020248 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 9.4e-13 216592020249 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 4.3e-11 216592020250 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.3e-10 216592020251 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.1e-07 216592020252 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1e-11 216592020253 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 8.9e-13 216592020254 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 6.3e-15 216592020255 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.4e-09 216592020256 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 3.3e-12 216592020257 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 7.5e-15 216592020258 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 2.3e-14 216592020259 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 5e-10 216592020260 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.4e-14 216592020261 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 7.4e-10 216592020262 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 3.1e-12 216592020263 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 1.5e-12 216592020264 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 5.3e-12 216592020265 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 3.8e-12 216592020266 HMMPfam hit to PF02369, Bacterial Ig-like domain (group 1), score 7.5e-07 216592020267 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 216592020268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020269 putative substrate translocation pore; other site 216592020270 12 probable transmembrane helices predicted for EC042_4013 by TMHMM2.0 at aa 34-56, 71-90, 102-121, 126-148, 161-183, 193-212, 233-255, 270-292, 299-318, 322-344, 357-379 and 383-405 216592020271 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-40 216592020272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 216592020273 HMMPfam hit to PF06296, Protein of unknown function (DUF1044), score 4e-68 216592020274 Predicted transcriptional regulator [Transcription]; Region: COG2944 216592020275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592020276 non-specific DNA binding site [nucleotide binding]; other site 216592020277 salt bridge; other site 216592020278 sequence-specific DNA binding site [nucleotide binding]; other site 216592020279 Predicted helix-turn-helix motif with score 1679.000, SD 4.91 at aa 50-82, sequence VEIKALREKLKVSQPVFAHYLNTSVSTVQKWES 216592020280 Predicted helix-turn-helix motif with score 1098.000, SD 2.93 at aa 50-71, sequence VEIKALREKLKVSQPVFAHYLN 216592020281 HMMPfam hit to PF01381, Helix-turn-helix, score 3.1e-07 216592020282 Predicted helix-turn-helix motif with score 1679.000, SD 4.91 at aa 61-82, sequence VSQPVFAHYLNTSVSTVQKWES 216592020283 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 216592020284 HMMPfam hit to PF06711, Protein of unknown function (DUF1198), score 9.8e-130 216592020285 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 216592020286 13 probable transmembrane helices predicted for EC042_4017 by TMHMM2.0 at aa 57-79, 89-111, 113-135, 140-162, 169-188, 203-225, 232-254, 280-302, 322-344, 354-376, 383-401, 416-438 and 451-469 216592020287 HMMPfam hit to PF00860, Permease family, score 3.3e-26 216592020288 cryptic adenine deaminase; Provisional; Region: PRK10027 216592020289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216592020290 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 216592020291 active site 216592020292 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216592020293 HMMPfam hit to PF01979, Amidohydrolase family, score 5.1e-53 216592020294 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 216592020295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020296 putative substrate translocation pore; other site 216592020297 12 probable transmembrane helices predicted for EC042_4019 by TMHMM2.0 at aa 28-46, 66-88, 97-116, 126-148, 160-182, 192-214, 254-276, 296-318, 325-347, 357-379, 392-411 and 426-445 216592020298 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6e-31 216592020299 PS00942 glpT family of transporters signature. 216592020300 regulatory protein UhpC; Provisional; Region: PRK11663 216592020301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020302 putative substrate translocation pore; other site 216592020303 12 probable transmembrane helices predicted for EC042_4020 by TMHMM2.0 at aa 27-46, 68-90, 97-119, 123-145, 157-179, 184-206, 246-268, 288-310, 323-345, 349-371, 378-400 and 410-432 216592020304 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3e-62 216592020305 PS00942 glpT family of transporters signature. 216592020306 sensory histidine kinase UhpB; Provisional; Region: PRK11644 216592020307 MASE1; Region: MASE1; pfam05231 216592020308 Histidine kinase; Region: HisKA_3; pfam07730 216592020309 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.8e-20 216592020310 HMMPfam hit to PF07730, Histidine kinase, score 1.5e-16 216592020311 HMMPfam hit to PF05231, MASE1, score 1.8e-76 216592020312 7 probable transmembrane helices predicted for EC042_4021 by TMHMM2.0 at aa 12-34, 79-101, 113-132, 142-164, 185-202, 222-244 and 256-275 216592020313 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 216592020314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592020315 active site 216592020316 phosphorylation site [posttranslational modification] 216592020317 intermolecular recognition site; other site 216592020318 dimerization interface [polypeptide binding]; other site 216592020319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592020320 DNA binding residues [nucleotide binding] 216592020321 dimerization interface [polypeptide binding]; other site 216592020322 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 1e-29 216592020323 PS00622 Bacterial regulatory proteins, luxR family signature. 216592020324 Predicted helix-turn-helix motif with score 1192.000, SD 3.25 at aa 153-174, sequence MAVKEIAAELGLSPKTVHVHRA 216592020325 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.2e-40 216592020326 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 216592020327 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 216592020328 putative valine binding site [chemical binding]; other site 216592020329 dimer interface [polypeptide binding]; other site 216592020330 HMMPfam hit to PF01842, ACT domain, score 4e-11 216592020331 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 216592020332 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216592020333 PYR/PP interface [polypeptide binding]; other site 216592020334 dimer interface [polypeptide binding]; other site 216592020335 TPP binding site [chemical binding]; other site 216592020336 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216592020337 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216592020338 TPP-binding site [chemical binding]; other site 216592020339 dimer interface [polypeptide binding]; other site 216592020340 PS00187 Thiamine pyrophosphate enzymes signature. 216592020341 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.6e-73 216592020342 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 4.6e-108 216592020344 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 216592020345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020346 putative substrate translocation pore; other site 216592020347 12 probable transmembrane helices predicted for EC042_4030 by TMHMM2.0 at aa 12-34, 47-69, 76-95, 100-122, 135-157, 167-184, 205-227, 242-264, 277-296, 301-323, 330-352 and 367-386 216592020348 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.9e-42 216592020349 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216592020350 Domain of unknown function (DUF202); Region: DUF202; pfam02656 216592020351 3 probable transmembrane helices predicted for EC042_4032 by TMHMM2.0 at aa 22-39, 43-65 and 91-113 216592020352 Predicted membrane protein [Function unknown]; Region: COG2149 216592020353 HMMPfam hit to PF02656, Domain of unknown function DUF, score 1.7e-69 216592020354 3 probable transmembrane helices predicted for EC042_4033 by TMHMM2.0 at aa 21-40, 50-72 and 92-114 216592020355 3 probable transmembrane helices predicted for EC042_4034 by TMHMM2.0 at aa 9-31, 78-97 and 118-140 216592020356 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216592020357 Sulfatase; Region: Sulfatase; pfam00884 216592020358 HMMPfam hit to PF00884, Sulfatase, score 9.5e-95 216592020359 PS00149 Sulfatases signature 2. 216592020360 PS00523 Sulfatases signature 1. 216592020361 putative transporter; Provisional; Region: PRK10484 216592020362 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 216592020363 Na binding site [ion binding]; other site 216592020364 15 probable transmembrane helices predicted for EC042_4036 by TMHMM2.0 at aa 4-22, 35-57, 72-94, 123-145, 160-182, 191-213, 242-261, 282-304, 327-349, 375-397, 412-429, 434-453, 458-480, 501-523 and 528-550 216592020365 HMMPfam hit to PF00474, Sodium:solute symporter family, score 1.7e-37 216592020366 PS00456 Sodium:solute symporter family signature 1. 216592020367 Present in 0157, absent in Uropathogenic, misc. sugar uptake operon (regulator, PTS protein and 6-phospho-beta-glucosidase) 216592020368 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216592020369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592020370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592020371 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 8.9e-21 216592020372 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.8e-08 216592020373 PS00041 Bacterial regulatory proteins, araC family signature. 216592020374 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.7e-09 216592020375 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 216592020376 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 216592020377 NAD binding site [chemical binding]; other site 216592020378 sugar binding site [chemical binding]; other site 216592020379 divalent metal binding site [ion binding]; other site 216592020380 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592020381 dimer interface [polypeptide binding]; other site 216592020382 HMMPfam hit to PF02056, Family 4 glycosyl hydrolase, score 2.7e-206 216592020383 PS01324 Glycosyl hydrolases family 4 signature. 216592020384 1 probable transmembrane helix predicted for EC042_4038 by TMHMM2.0 at aa 5-27 216592020385 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 216592020386 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 216592020387 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592020388 active site turn [active] 216592020389 phosphorylation site [posttranslational modification] 216592020390 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 2.7e-16 216592020391 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592020392 11 probable transmembrane helices predicted for EC042_4039 by TMHMM2.0 at aa 97-119, 178-200, 215-237, 249-271, 286-308, 320-342, 365-387, 394-411, 416-433, 440-459 and 474-496 216592020393 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1e-90 216592020394 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216592020395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592020396 DNA-binding site [nucleotide binding]; DNA binding site 216592020397 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 216592020398 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 5.6e-25 216592020399 PS00043 Bacterial regulatory proteins, gntR family signature. 216592020400 Predicted helix-turn-helix motif with score 1273.000, SD 3.52 at aa 26-47, sequence PGEKKLAEEFAVSRMTIRKAID 216592020401 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 2.1e-37 216592020402 putative transporter; Validated; Region: PRK03818 216592020403 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 216592020404 TrkA-C domain; Region: TrkA_C; pfam02080 216592020405 TrkA-C domain; Region: TrkA_C; pfam02080 216592020406 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 216592020407 10 probable transmembrane helices predicted for EC042_4041 by TMHMM2.0 at aa 4-22, 29-51, 61-83, 90-112, 160-182, 371-393, 403-425, 437-459, 463-485 and 530-552 216592020408 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1.2e-65 216592020409 HMMPfam hit to PF02080, TrkA-C domain, score 3.1e-14 216592020410 HMMPfam hit to PF02080, TrkA-C domain, score 1e-10 216592020411 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 4.4e-65 216592020412 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216592020413 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 216592020414 putative dimer interface [polypeptide binding]; other site 216592020415 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 1.6e-29 216592020416 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216592020417 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 216592020418 putative dimer interface [polypeptide binding]; other site 216592020419 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 9.9e-33 216592020420 hypothetical protein; Provisional; Region: PRK11616 216592020421 HMMPfam hit to PF07119, Protein of unknown function (DUF1375), score 1.1e-47 216592020422 1 probable transmembrane helix predicted for EC042_4044 by TMHMM2.0 at aa 29-51 216592020423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592020424 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 216592020425 putative oxidoreductase; Provisional; Region: PRK11445 216592020426 hypothetical protein; Provisional; Region: PRK07236 216592020427 Present in Uropathogenic, absent in 0157, galactonate utilization operon 216592020428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020429 D-galactonate transporter; Region: 2A0114; TIGR00893 216592020430 putative substrate translocation pore; other site 216592020431 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.2e-05 216592020432 10 probable transmembrane helices predicted for EC042_4047 by TMHMM2.0 at aa 31-53, 68-90, 97-119, 181-203, 257-278, 293-315, 322-344, 354-376, 389-411 and 416-438 216592020433 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.3e-66 216592020434 galactonate dehydratase; Provisional; Region: PRK14017 216592020435 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 216592020436 putative active site pocket [active] 216592020437 putative metal binding site [ion binding]; other site 216592020438 HMMPfam hit to PF01188, Mandelate racemase / muconate lactonizing en, score 5.7e-124 216592020439 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 216592020440 HMMPfam hit to PF02746, Mandelate racemase / muconate lactonizing en, score 4.1e-54 216592020441 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216592020442 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 216592020443 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216592020444 active site 216592020445 intersubunit interface [polypeptide binding]; other site 216592020446 catalytic residue [active] 216592020447 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.5e-10 216592020448 PS00606 Beta-ketoacyl synthases active site. 216592020449 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 216592020450 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 216592020451 HMMPfam hit to PF05035, 2-keto-3-deoxy-galactonokinase, score 1.1e-214 216592020452 PS00761 Signal peptidases I signature 3. 216592020453 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216592020454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592020455 DNA-binding site [nucleotide binding]; DNA binding site 216592020456 FCD domain; Region: FCD; pfam07729 216592020457 HMMPfam hit to PF07729, FCD domain, score 2.6e-36 216592020458 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.9e-14 216592020459 PS00043 Bacterial regulatory proteins, gntR family signature. 216592020460 hypothetical protein; Provisional; Region: PRK10215 216592020461 1 probable transmembrane helix predicted for EC042_4052 by TMHMM2.0 at aa 7-29 216592020462 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592020463 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216592020464 sugar phosphate phosphatase; Provisional; Region: PRK10513 216592020465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592020466 active site 216592020467 motif I; other site 216592020468 motif II; other site 216592020469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592020470 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 6.9e-15 216592020471 PS01229 Hypothetical cof family signature 2. 216592020472 PS01228 Hypothetical cof family signature 1. 216592020473 hypothetical protein; Provisional; Region: PRK11426 216592020474 HMMPfam hit to PF06078, Bacterial protein of unknown function (DUF93, score 7.6e-45 216592020475 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 216592020476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592020477 Mg2+ binding site [ion binding]; other site 216592020478 G-X-G motif; other site 216592020479 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216592020480 anchoring element; other site 216592020481 dimer interface [polypeptide binding]; other site 216592020482 ATP binding site [chemical binding]; other site 216592020483 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 216592020484 active site 216592020485 putative metal-binding site [ion binding]; other site 216592020486 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216592020487 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 1.9e-47 216592020488 HMMPfam hit to PF01751, Toprim domain, score 2e-05 216592020489 PS00177 DNA topoisomerase II signature. 216592020490 HMMPfam hit to PF00204, DNA gyrase B, score 5e-95 216592020491 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.8e-33 216592020492 recF protein; Region: recf; TIGR00611 216592020493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592020494 Walker A/P-loop; other site 216592020495 ATP binding site [chemical binding]; other site 216592020496 Q-loop/lid; other site 216592020497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592020498 ABC transporter signature motif; other site 216592020499 Walker B; other site 216592020500 D-loop; other site 216592020501 H-loop/switch region; other site 216592020502 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 1.3e-158 216592020503 PS00618 RecF protein signature 2. 216592020504 PS00617 RecF protein signature 1. 216592020505 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020506 DNA polymerase III subunit beta; Validated; Region: PRK05643 216592020507 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 216592020508 putative DNA binding surface [nucleotide binding]; other site 216592020509 dimer interface [polypeptide binding]; other site 216592020510 beta-clamp/clamp loader binding surface; other site 216592020511 beta-clamp/translesion DNA polymerase binding surface; other site 216592020512 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 2.9e-64 216592020513 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 1e-67 216592020514 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 5.1e-67 216592020515 DnaA N-terminal domain; Region: DnaA_N; pfam11638 216592020516 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 216592020517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592020518 Walker A motif; other site 216592020519 ATP binding site [chemical binding]; other site 216592020520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216592020521 Walker B motif; other site 216592020522 arginine finger; other site 216592020523 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 216592020524 DnaA box-binding interface [nucleotide binding]; other site 216592020525 HMMPfam hit to PF00308, Bacterial dnaA protein, score 1.2e-218 216592020526 PS01008 DnaA protein signature. 216592020527 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020528 ribonuclease P; Reviewed; Region: rnpA; PRK01732 216592020529 HMMPfam hit to PF00825, Ribonuclease P, score 1.3e-52 216592020530 PS00648 Bacterial ribonuclease P protein component signature. 216592020531 hypothetical protein; Validated; Region: PRK00041 216592020532 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 6.1e-49 216592020533 membrane protein insertase; Provisional; Region: PRK01318 216592020534 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 216592020535 4 probable transmembrane helices predicted for EC042_4062 by TMHMM2.0 at aa 7-24, 346-368, 419-441 and 497-519 216592020536 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 9.2e-125 216592020537 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 216592020538 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 216592020539 trmE is a tRNA modification GTPase; Region: trmE; cd04164 216592020540 G1 box; other site 216592020541 GTP/Mg2+ binding site [chemical binding]; other site 216592020542 Switch I region; other site 216592020543 G2 box; other site 216592020544 Switch II region; other site 216592020545 G3 box; other site 216592020546 G4 box; other site 216592020547 G5 box; other site 216592020548 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 216592020549 HMMPfam hit to PF01926, GTPase of unknown function, score 1e-42 216592020550 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020551 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 216592020552 Predicted helix-turn-helix motif with score 1053.000, SD 2.77 at aa 409-430, sequence INLKELARKYNFSYGDLENILL 216592020553 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 216592020554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216592020555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216592020556 catalytic residue [active] 216592020557 HMMPfam hit to PF01212, Beta-eliminating lyase, score 1.1e-198 216592020558 PS00853 Beta-eliminating lyases pyridoxal-phosphate attachment site. 216592020559 tryptophan permease TnaB; Provisional; Region: PRK09664 216592020560 aromatic amino acid transport protein; Region: araaP; TIGR00837 216592020561 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 1.9e-230 216592020562 11 probable transmembrane helices predicted for EC042_4066 by TMHMM2.0 at aa 12-34, 39-61, 82-104, 124-146, 153-175, 195-217, 230-252, 285-307, 320-342, 347-369 and 382-404 216592020563 PS00594 Aromatic amino acids permeases signature. 216592020564 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 216592020565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020566 putative substrate translocation pore; other site 216592020567 11 probable transmembrane helices predicted for EC042_4067 by TMHMM2.0 at aa 5-27, 42-59, 72-94, 99-116, 129-151, 156-178, 203-222, 242-264, 276-309, 324-346 and 353-375 216592020568 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4.8e-05 216592020569 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-50 216592020570 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 216592020571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592020572 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 216592020573 substrate binding pocket [chemical binding]; other site 216592020574 dimerization interface [polypeptide binding]; other site 216592020575 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3e-16 216592020576 Predicted helix-turn-helix motif with score 1761.000, SD 5.18 at aa 26-47, sequence RSVTKAAKRMNVTPSAVSKSLA 216592020577 PS00044 Bacterial regulatory proteins, lysR family signature. 216592020578 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.8e-11 216592020579 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 216592020580 Predicted flavoprotein [General function prediction only]; Region: COG0431 216592020581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216592020582 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 9.3e-65 216592020583 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 216592020584 13 probable transmembrane helices predicted for EC042_4071 by TMHMM2.0 at aa 30-52, 62-84, 86-108, 113-135, 142-161, 176-198, 205-222, 253-275, 295-317, 327-349, 356-374, 389-411 and 424-442 216592020585 HMMPfam hit to PF00860, Permease family, score 7.2e-25 216592020586 PS00267 Tachykinin family signature. 216592020587 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 216592020588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592020589 active site 216592020590 motif I; other site 216592020591 motif II; other site 216592020592 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.1e-21 216592020593 Present in 0157, divergent in Uropathogenic, misc. proteins 216592020594 chromosome segregation protein; Provisional; Region: PRK02224 216592020595 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216592020596 transcriptional regulator PhoU; Provisional; Region: PRK11115 216592020597 PhoU domain; Region: PhoU; pfam01895 216592020598 PhoU domain; Region: PhoU; pfam01895 216592020599 HMMPfam hit to PF01895, PhoU family, score 1.4e-30 216592020600 HMMPfam hit to PF01895, PhoU family, score 2.5e-31 216592020601 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 216592020602 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 216592020603 Walker A/P-loop; other site 216592020604 ATP binding site [chemical binding]; other site 216592020605 Q-loop/lid; other site 216592020606 ABC transporter signature motif; other site 216592020607 Walker B; other site 216592020608 D-loop; other site 216592020609 H-loop/switch region; other site 216592020610 HMMPfam hit to PF00005, ABC transporter, score 1.2e-72 216592020611 PS00211 ABC transporters family signature. 216592020612 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020613 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 216592020614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592020615 dimer interface [polypeptide binding]; other site 216592020616 conserved gate region; other site 216592020617 putative PBP binding loops; other site 216592020618 ABC-ATPase subunit interface; other site 216592020619 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.5e-39 216592020620 6 probable transmembrane helices predicted for EC042_4078 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 216592020621 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592020622 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 216592020623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592020624 dimer interface [polypeptide binding]; other site 216592020625 conserved gate region; other site 216592020626 putative PBP binding loops; other site 216592020627 ABC-ATPase subunit interface; other site 216592020628 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.6e-09 216592020629 6 probable transmembrane helices predicted for EC042_4079 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 216592020630 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592020631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592020632 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 9.2e-33 216592020633 1 probable transmembrane helix predicted for EC042_4080 by TMHMM2.0 at aa 7-29 216592020634 Absent in Uropathogenic, divergent in 0157, putative composite island containing integron (?), (fimbrial usher genes, chloramphenicol acteyl transferase, transposase, Streptomycin adenyltransferase, thidium bromide resistance protein, mercuric resistance operon, tetracycline resistance), IS element repeats flank integron 216592020635 Fimbrial operon 11 216592020636 Fimbrial protein; Region: Fimbrial; cl01416 216592020637 1 probable transmembrane helix predicted for EC042_4081 by TMHMM2.0 at aa 5-24 216592020638 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216592020639 PapC N-terminal domain; Region: PapC_N; pfam13954 216592020640 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592020641 PapC C-terminal domain; Region: PapC_C; pfam13953 216592020642 HMMPfam hit to PF00577, Fimbrial Usher protein, score 0 216592020643 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 216592020644 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592020645 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592020646 HMMPfam hit to PF02753, Gram-negative pili assembly chaperone, score 1.5e-09 216592020647 HMMPfam hit to PF00345, Gram-negative pili assembly chaperone, score 1.5e-41 216592020648 PS00635 Gram-negative pili assembly chaperone signature. 216592020649 1 probable transmembrane helix predicted for EC042_4083 by TMHMM2.0 at aa 19-41 216592020650 fimbrial protein; Provisional; Region: lpfA; PRK15289 216592020651 HMMPfam hit to PF00419, Fimbrial protein, score 3.4e-41 216592020652 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 216592020653 HMMPfam hit to PF03400, IS1 transposase, score 5.9e-113 216592020654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592020655 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592020656 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592020657 HMMPfam hit to PF03811, Insertion element protein, score 5.7e-69 216592020658 Predicted helix-turn-helix motif with score 1462.000, SD 4.17 at aa 64-85, sequence VGCRATARIMGVGLNTIFRHLK 216592020659 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020660 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 216592020661 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 216592020662 HMMPfam hit to PF00302, Chloramphenicol acetyltransferase, score 5.3e-156 216592020663 PS00100 Chloramphenicol acetyltransferase active site. 216592020664 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216592020665 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 216592020666 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 216592020667 Tn2411 216592020668 HMMPfam hit to PF01526, Transposase, score 0 216592020669 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216592020670 multiple promoter invertase; Provisional; Region: mpi; PRK13413 216592020671 catalytic residues [active] 216592020672 catalytic nucleophile [active] 216592020673 Presynaptic Site I dimer interface [polypeptide binding]; other site 216592020674 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216592020675 Synaptic Flat tetramer interface [polypeptide binding]; other site 216592020676 Synaptic Site I dimer interface [polypeptide binding]; other site 216592020677 DNA binding site [nucleotide binding] 216592020678 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216592020679 DNA-binding interface [nucleotide binding]; DNA binding site 216592020680 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 2.6e-16 216592020681 Predicted helix-turn-helix motif with score 2227.000, SD 6.77 at aa 162-183, sequence EQKTKLAREFGISRETLYQYLR 216592020682 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 3.4e-72 216592020683 PS00398 Site-specific recombinases signature 2. 216592020684 PS00397 Site-specific recombinases active site. 216592020685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592020686 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 216592020687 boundaries of In2; a class 1, sul1-associated integron 216592020688 integrase/recombinase; Provisional; Region: PRK15417 216592020689 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216592020690 Int/Topo IB signature motif; other site 216592020691 HMMPfam hit to PF00589, Phage integrase family, score 3.1e-58 216592020692 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 0.00088 216592020693 aminoglycoside resistance protein; Provisional; Region: PRK13746 216592020694 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216592020695 active site 216592020696 NTP binding site [chemical binding]; other site 216592020697 metal binding triad [ion binding]; metal-binding site 216592020698 antibiotic binding site [chemical binding]; other site 216592020699 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 216592020700 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 2.3e-14 216592020701 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 216592020702 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.7e-49 216592020703 4 probable transmembrane helices predicted for EC042_4094 by TMHMM2.0 at aa 3-20, 30-49, 56-78 and 83-101 216592020704 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216592020705 dihydropteroate synthase; Region: DHPS; TIGR01496 216592020706 substrate binding pocket [chemical binding]; other site 216592020707 dimer interface [polypeptide binding]; other site 216592020708 inhibitor binding site; inhibition site 216592020709 PS00792 Dihydropteroate synthase signature 1. 216592020710 HMMPfam hit to PF00809, Pterin binding enzyme, score 2.8e-84 216592020711 PS00793 Dihydropteroate synthase signature 2. 216592020712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216592020713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592020714 Coenzyme A binding pocket [chemical binding]; other site 216592020715 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.6e-18 216592020716 transposase/IS protein; Provisional; Region: PRK09183 216592020717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592020718 Walker A motif; other site 216592020719 ATP binding site [chemical binding]; other site 216592020720 Walker B motif; other site 216592020721 arginine finger; other site 216592020722 HMMPfam hit to PF01695, IstB-like ATP binding protein, score 2e-100 216592020723 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020724 PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 216592020725 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216592020726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 216592020727 Integrase core domain; Region: rve; pfam00665 216592020728 HMMPfam hit to PF00665, Integrase core domain, score 4e-15 216592020729 Predicted helix-turn-helix motif with score 2056.000, SD 6.19 at aa 19-40, sequence ASIREIARRSGLSRNTVRKYLQ 216592020730 Bacterial TniB protein; Region: TniB; pfam05621 216592020731 HMMPfam hit to PF05621, Bacterial TniB protein, score 3.3e-248 216592020732 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020733 Integrase core domain; Region: rve; pfam00665 216592020734 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 216592020735 HMMPfam hit to PF00665, Integrase core domain, score 1.9e-26 216592020736 Predicted helix-turn-helix motif with score 1212.000, SD 3.31 at aa 55-76, sequence EAADMAAQALGLSRRQVYVLIR 216592020737 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592020738 HMMPfam hit to PF00563, EAL domain, score 1.3e-82 216592020739 putative mercury resistance protein; Provisional; Region: PRK13747 216592020740 transcriptional regulator MerD; Provisional; Region: PRK13749 216592020741 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216592020742 DNA binding residues [nucleotide binding] 216592020743 HMMPfam hit to PF00376, MerR family regulatory protein, score 5.5e-05 216592020744 putative mercuric reductase; Provisional; Region: PRK13748 216592020745 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216592020746 metal-binding site [ion binding] 216592020747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216592020748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592020749 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216592020750 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 1e-45 216592020751 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 5.2e-85 216592020752 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216592020753 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 5.3e-12 216592020754 PS01047 Heavy-metal-associated domain. 216592020755 putative mercury transport protein MerC; Provisional; Region: PRK13755 216592020756 HMMPfam hit to PF03203, MerC mercury resistance protein, score 4e-100 216592020757 4 probable transmembrane helices predicted for EC042_4105 by TMHMM2.0 at aa 13-35, 45-67, 72-94 and 99-118 216592020758 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216592020759 metal-binding site [ion binding] 216592020760 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 8e-13 216592020761 PS01047 Heavy-metal-associated domain. 216592020762 putative mercuric transport protein; Provisional; Region: PRK13751 216592020763 HMMPfam hit to PF02411, MerT mercuric transport protein, score 5e-88 216592020764 3 probable transmembrane helices predicted for EC042_4107 by TMHMM2.0 at aa 12-34, 49-66 and 93-115 216592020765 putative transcriptional regulator MerR; Provisional; Region: PRK13752 216592020766 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 216592020767 DNA binding residues [nucleotide binding] 216592020768 dimer interface [polypeptide binding]; other site 216592020769 mercury binding site [ion binding]; other site 216592020770 Predicted helix-turn-helix motif with score 1571.000, SD 4.54 at aa 24-45, sequence LTIGVFAKAAGVNVETIRFYQR 216592020771 HMMPfam hit to PF00376, MerR family regulatory protein, score 5.2e-09 216592020772 PS00552 Bacterial regulatory proteins, merR family signature. 216592020773 tetracycline repressor protein TetR; Provisional; Region: PRK13756 216592020774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592020775 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 216592020776 HMMPfam hit to PF02909, Tetracyclin repressor, C-terminal all-alpha, score 4.1e-69 216592020777 PS00777 Glycosyl hydrolases family 11 active site signature 2. 216592020778 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.3e-18 216592020779 PS01081 Bacterial regulatory proteins, tetR family signature. 216592020780 Predicted helix-turn-helix motif with score 2151.000, SD 6.51 at aa 34-55, sequence LTTRKLAERLGVQQPALYWHFR 216592020781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216592020783 putative substrate translocation pore; other site 216592020784 12 probable transmembrane helices predicted for EC042_4111 by TMHMM2.0 at aa 32-54, 69-91, 98-120, 124-146, 158-180, 185-207, 228-250, 270-292, 304-323, 327-349, 361-383 and 393-415 216592020785 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-53 216592020786 PS00216 Sugar transport proteins signature 1. 216592020787 CDS is truncated by the insertion of the upstream IS1R element and subsequent recombination events. Similar to the C-terminal region of Erwinia chrysanthemi protein PecM UniProt:P42194 (EMBL:ECPEC) (297 aa) fasta scores: E()=4.6e-28, 43.781% id in 201 aa 216592020788 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.3e-27 216592020789 7 probable transmembrane helices predicted for EC042_4112 by TMHMM2.0 at aa 10-32, 39-61, 65-83, 90-112, 127-149, 156-175 and 180-198 216592020790 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 216592020791 HMMPfam hit to PF03400, IS1 transposase, score 5.9e-113 216592020792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592020793 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592020794 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592020795 HMMPfam hit to PF03811, Insertion element protein, score 5.7e-69 216592020796 Predicted helix-turn-helix motif with score 1462.000, SD 4.17 at aa 64-85, sequence VGCRATARIMGVGLNTIFRHLK 216592020797 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020798 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216592020799 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 216592020800 glutaminase active site [active] 216592020801 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216592020802 dimer interface [polypeptide binding]; other site 216592020803 active site 216592020804 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216592020805 dimer interface [polypeptide binding]; other site 216592020806 active site 216592020807 HMMPfam hit to PF01380, SIS domain, score 8.5e-40 216592020808 HMMPfam hit to PF01380, SIS domain, score 3.4e-41 216592020809 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 4.3e-73 216592020810 PS00443 Glutamine amidotransferases class-II active site. 216592020811 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 216592020812 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 216592020813 Substrate binding site; other site 216592020814 Mg++ binding site; other site 216592020815 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 216592020816 active site 216592020817 substrate binding site [chemical binding]; other site 216592020818 CoA binding site [chemical binding]; other site 216592020819 PS00101 Hexapeptide-repeat containing-transferases signature. 216592020820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 2.5 216592020821 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 12 216592020822 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 1.9 216592020823 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 27 216592020824 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.038 216592020825 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.074 216592020826 HMMPfam hit to PF00483, Nucleotidyl transferase, score 7.7e-08 216592020827 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 216592020828 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 216592020829 gamma subunit interface [polypeptide binding]; other site 216592020830 epsilon subunit interface [polypeptide binding]; other site 216592020831 LBP interface [polypeptide binding]; other site 216592020832 HMMPfam hit to PF00401, ATP synthase, Delta/Epsilon chain, long, score 1.4e-12 216592020833 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 1.1e-39 216592020834 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 216592020835 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216592020836 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 216592020837 alpha subunit interaction interface [polypeptide binding]; other site 216592020838 Walker A motif; other site 216592020839 ATP binding site [chemical binding]; other site 216592020840 Walker B motif; other site 216592020841 inhibitor binding site; inhibition site 216592020842 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216592020843 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 1e-49 216592020844 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1.1e-90 216592020845 PS00152 ATP synthase alpha and beta subunits signature. 216592020846 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020847 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 1.5e-25 216592020848 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 216592020849 core domain interface [polypeptide binding]; other site 216592020850 delta subunit interface [polypeptide binding]; other site 216592020851 epsilon subunit interface [polypeptide binding]; other site 216592020852 HMMPfam hit to PF00231, ATP synthase, score 5.8e-179 216592020853 PS00153 ATP synthase gamma subunit signature. 216592020854 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 216592020855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216592020856 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 216592020857 beta subunit interaction interface [polypeptide binding]; other site 216592020858 Walker A motif; other site 216592020859 ATP binding site [chemical binding]; other site 216592020860 Walker B motif; other site 216592020861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216592020862 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 2.6e-25 216592020863 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 8.1e-112 216592020864 PS00152 ATP synthase alpha and beta subunits signature. 216592020865 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020866 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.2e-16 216592020867 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 216592020868 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 216592020869 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 2.1e-76 216592020870 PS00389 ATP synthase delta (OSCP) subunit signature. 216592020871 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 216592020872 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 216592020873 HMMPfam hit to PF00430, ATP synthase B/B' CF(0), score 1.1e-44 216592020874 1 probable transmembrane helix predicted for EC042_4123 by TMHMM2.0 at aa 5-27 216592020875 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 216592020876 HMMPfam hit to PF00137, ATP synthase subunit C, score 1.1e-24 216592020877 2 probable transmembrane helices predicted for EC042_4124 by TMHMM2.0 at aa 10-32 and 53-75 216592020878 PS00605 ATP synthase c subunit signature. 216592020879 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 216592020880 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 216592020881 HMMPfam hit to PF00119, ATP synthase A chain, score 7.8e-75 216592020882 5 probable transmembrane helices predicted for EC042_4125 by TMHMM2.0 at aa 38-60, 100-122, 147-166, 211-233 and 243-265 216592020883 PS00449 ATP synthase a subunit signature. 216592020884 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 216592020885 HMMPfam hit to PF03899, ATP synthase I chain, score 1.7e-71 216592020886 4 probable transmembrane helices predicted for EC042_4126 by TMHMM2.0 at aa 15-32, 37-59, 74-96 and 101-123 216592020887 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 216592020888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592020889 S-adenosylmethionine binding site [chemical binding]; other site 216592020890 HMMPfam hit to PF02527, Glucose inhibited division protein, score 1.2e-99 216592020891 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 216592020892 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 216592020893 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 216592020894 Predicted helix-turn-helix motif with score 1120.000, SD 3.00 at aa 596-617, sequence ASIGQASRISGVTPAAISILLV 216592020895 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 2.4e-278 216592020896 PS01281 Glucose inhibited division protein A family signature 2. 216592020897 PS01280 Glucose inhibited division protein A family signature 1. 216592020898 FMN-binding protein MioC; Provisional; Region: PRK09004 216592020899 HMMPfam hit to PF00258, Flavodoxin, score 9.8e-32 216592020900 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 216592020901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592020902 putative DNA binding site [nucleotide binding]; other site 216592020903 putative Zn2+ binding site [ion binding]; other site 216592020904 AsnC family; Region: AsnC_trans_reg; pfam01037 216592020905 HMMPfam hit to PF01037, AsnC family, score 1.3e-17 216592020906 PS00519 Bacterial regulatory proteins, asnC family signature. 216592020907 Predicted helix-turn-helix motif with score 1689.000, SD 4.94 at aa 23-44, sequence TAYAELAKQFGVSPGTIHVRVE 216592020908 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 216592020909 dimer interface [polypeptide binding]; other site 216592020910 active site 216592020911 HMMPfam hit to PF03590, Aspartate-ammonia ligase, score 1.2e-183 216592020912 hypothetical protein; Provisional; Region: yieM; PRK10997 216592020913 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 216592020914 metal ion-dependent adhesion site (MIDAS); other site 216592020915 regulatory ATPase RavA; Provisional; Region: PRK13531 216592020916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592020917 Walker A motif; other site 216592020918 ATP binding site [chemical binding]; other site 216592020919 Walker B motif; other site 216592020920 arginine finger; other site 216592020921 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 216592020922 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.2e-70 216592020923 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 216592020924 potassium uptake protein; Region: kup; TIGR00794 216592020925 12 probable transmembrane helices predicted for EC042_4134 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 335-357, 363-385, 392-414 and 419-441 216592020926 HMMPfam hit to PF02705, K+ potassium transporter, score 0 216592020927 D-ribose pyranase; Provisional; Region: PRK11797 216592020928 HMMPfam hit to PF05025, RbsD / FucU transport protein family, score 2.6e-90 216592020929 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 216592020930 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216592020931 Walker A/P-loop; other site 216592020932 ATP binding site [chemical binding]; other site 216592020933 Q-loop/lid; other site 216592020934 ABC transporter signature motif; other site 216592020935 Walker B; other site 216592020936 D-loop; other site 216592020937 H-loop/switch region; other site 216592020938 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216592020939 HMMPfam hit to PF00005, ABC transporter, score 1.1e-51 216592020940 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020941 HMMPfam hit to PF00005, ABC transporter, score 6.9e-34 216592020942 PS00211 ABC transporters family signature. 216592020943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592020944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592020945 TM-ABC transporter signature motif; other site 216592020946 8 probable transmembrane helices predicted for EC042_4137 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 97-119, 126-145, 165-187, 221-243 and 275-297 216592020947 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 8.8e-73 216592020948 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 216592020949 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 216592020950 ligand binding site [chemical binding]; other site 216592020951 dimerization interface [polypeptide binding]; other site 216592020952 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 4.1e-21 216592020953 PS00017 ATP/GTP-binding site motif A (P-loop). 216592020954 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 216592020955 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592020956 substrate binding site [chemical binding]; other site 216592020957 dimer interface [polypeptide binding]; other site 216592020958 ATP binding site [chemical binding]; other site 216592020959 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 8.8e-98 216592020960 PS00583 pfkB family of carbohydrate kinases signature 1. 216592020961 PS00584 pfkB family of carbohydrate kinases signature 2. 216592020962 transcriptional repressor RbsR; Provisional; Region: PRK10423 216592020963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592020964 DNA binding site [nucleotide binding] 216592020965 domain linker motif; other site 216592020966 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 216592020967 dimerization interface [polypeptide binding]; other site 216592020968 ligand binding site [chemical binding]; other site 216592020969 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.2e-12 216592020970 Predicted helix-turn-helix motif with score 2156.000, SD 6.53 at aa 2-23, sequence ATMKDVARLAGVSTSTVSHVIN 216592020971 PS00356 Bacterial regulatory proteins, lacI family signature. 216592020972 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 5.6e-24 216592020973 putative transporter; Provisional; Region: PRK10504 216592020974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020975 putative substrate translocation pore; other site 216592020976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592020977 14 probable transmembrane helices predicted for EC042_4141 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 103-125, 137-159, 164-183, 196-218, 222-244, 264-286, 291-313, 325-347, 351-373, 394-416 and 431-450 216592020978 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-46 216592020979 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216592020980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592020981 DNA-binding site [nucleotide binding]; DNA binding site 216592020982 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592020983 HMMPfam hit to PF07729, FCD domain, score 2.2e-32 216592020984 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 5e-21 216592020985 PS00043 Bacterial regulatory proteins, gntR family signature. 216592020986 Predicted helix-turn-helix motif with score 1101.000, SD 2.94 at aa 38-59, sequence PGEIELGEQFGVSRTAVREAVK 216592020987 transcriptional regulator HdfR; Provisional; Region: PRK03601 216592020988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592020989 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216592020990 dimerization interface [polypeptide binding]; other site 216592020991 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-05 216592020992 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.1e-19 216592020993 PS00044 Bacterial regulatory proteins, lysR family signature. 216592020994 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 16-37, sequence RHFGRAAESLYLTQSAVSFRIR 216592020995 hypothetical protein; Provisional; Region: PRK11027 216592020996 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 4.3e-49 216592020997 putative ATP-dependent protease; Provisional; Region: PRK09862 216592020998 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216592020999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592021000 Walker A motif; other site 216592021001 ATP binding site [chemical binding]; other site 216592021002 Walker B motif; other site 216592021003 arginine finger; other site 216592021004 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 216592021005 HMMPfam hit to PF01078, Magnesium chelatase, subunit ChlI, score 2.5e-121 216592021006 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021007 ilvG operon leader peptide; Provisional; Region: PRK10424 216592021008 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 216592021009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216592021010 PYR/PP interface [polypeptide binding]; other site 216592021011 dimer interface [polypeptide binding]; other site 216592021012 TPP binding site [chemical binding]; other site 216592021013 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216592021014 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216592021015 TPP-binding site [chemical binding]; other site 216592021016 dimer interface [polypeptide binding]; other site 216592021017 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.2e-104 216592021018 PS00044 Bacterial regulatory proteins, lysR family signature. 216592021019 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 1.8e-76 216592021020 PS00187 Thiamine pyrophosphate enzymes signature. 216592021021 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 216592021022 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216592021023 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 216592021024 homodimer interface [polypeptide binding]; other site 216592021025 substrate-cofactor binding pocket; other site 216592021026 catalytic residue [active] 216592021027 HMMPfam hit to PF01063, Aminotransferase class IV, score 2.1e-143 216592021028 PS00770 Aminotransferases class-IV signature. 216592021029 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 216592021030 HMMPfam hit to PF00920, Dehydratase family, score 0 216592021031 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 216592021032 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021033 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 216592021034 threonine dehydratase; Reviewed; Region: PRK09224 216592021035 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216592021036 tetramer interface [polypeptide binding]; other site 216592021037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592021038 catalytic residue [active] 216592021039 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 216592021040 putative Ile/Val binding site [chemical binding]; other site 216592021041 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 216592021042 putative Ile/Val binding site [chemical binding]; other site 216592021043 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.7e-105 216592021044 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216592021045 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 1e-48 216592021046 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 7.3e-44 216592021047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592021048 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 216592021049 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 216592021050 putative dimerization interface [polypeptide binding]; other site 216592021051 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-32 216592021052 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.1e-23 216592021053 PS00044 Bacterial regulatory proteins, lysR family signature. 216592021054 Predicted helix-turn-helix motif with score 1925.000, SD 5.74 at aa 44-65, sequence RHFGRSARAMHVSPSTLSRQIQ 216592021055 ketol-acid reductoisomerase; Validated; Region: PRK05225 216592021056 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 216592021057 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 216592021058 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 216592021059 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 4.3e-135 216592021060 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 216592021061 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 216592021062 HMMPfam hit to PF00639, PPIC-type PPIASE domain, score 1.2e-45 216592021063 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216592021064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 216592021065 PS00215 Mitochondrial energy transfer proteins signature. 216592021066 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 216592021067 Part of AAA domain; Region: AAA_19; pfam13245 216592021068 Family description; Region: UvrD_C_2; pfam13538 216592021069 HMMPfam hit to PF00580, UvrD/REP helicase, score 1e-223 216592021070 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021071 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 216592021072 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216592021073 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 1.6e-143 216592021074 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 216592021075 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216592021076 ATP binding site [chemical binding]; other site 216592021077 Mg++ binding site [ion binding]; other site 216592021078 motif III; other site 216592021079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592021080 nucleotide binding region [chemical binding]; other site 216592021081 ATP-binding site [chemical binding]; other site 216592021082 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.7e-33 216592021083 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.5e-60 216592021084 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216592021085 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021086 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216592021087 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216592021088 catalytic residues [active] 216592021089 HMMPfam hit to PF00085, Thioredoxin, score 1.2e-52 216592021090 PS00194 Thioredoxin family active site. 216592021091 transcription termination factor Rho; Provisional; Region: rho; PRK09376 216592021092 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 216592021093 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 216592021094 RNA binding site [nucleotide binding]; other site 216592021095 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 216592021096 multimer interface [polypeptide binding]; other site 216592021097 Walker A motif; other site 216592021098 ATP binding site [chemical binding]; other site 216592021099 Walker B motif; other site 216592021100 HMMPfam hit to PF07498, Rho termination factor, N-terminal domai, score 1.8e-20 216592021101 HMMPfam hit to PF07497, Rho termination factor, RNA-binding doma, score 3.4e-59 216592021102 PS00464 Ribosomal protein L22 signature. 216592021103 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 1.3e-68 216592021104 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021105 1 probable transmembrane helix predicted for EC042_4160 by TMHMM2.0 at aa 7-29 216592021106 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 216592021107 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 216592021108 Mg++ binding site [ion binding]; other site 216592021109 putative catalytic motif [active] 216592021110 substrate binding site [chemical binding]; other site 216592021111 11 probable transmembrane helices predicted for EC042_4161 by TMHMM2.0 at aa 5-24, 45-66, 70-89, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338 216592021112 HMMPfam hit to PF00953, Glycosyl transferase, score 2.7e-11 216592021113 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 216592021114 Chain length determinant protein; Region: Wzz; pfam02706 216592021115 HMMPfam hit to PF02706, Chain length determinant protein, score 4.7e-19 216592021116 2 probable transmembrane helices predicted for EC042_4162 by TMHMM2.0 at aa 30-52 and 324-343 216592021117 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 216592021118 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 216592021119 active site 216592021120 homodimer interface [polypeptide binding]; other site 216592021121 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 1.4e-214 216592021122 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 216592021123 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 216592021124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216592021125 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 216592021126 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 2.9e-97 216592021127 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 9.5e-47 216592021128 PS00678 Trp-Asp (WD) repeats signature. 216592021129 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 9.8e-32 216592021130 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 216592021131 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 216592021132 NAD binding site [chemical binding]; other site 216592021133 substrate binding site [chemical binding]; other site 216592021134 homodimer interface [polypeptide binding]; other site 216592021135 active site 216592021136 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1e-220 216592021137 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216592021138 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216592021139 substrate binding site; other site 216592021140 tetramer interface; other site 216592021141 HMMPfam hit to PF00483, Nucleotidyl transferase, score 4.7e-117 216592021142 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 216592021143 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1e-06 216592021144 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216592021145 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216592021146 inhibitor-cofactor binding pocket; inhibition site 216592021147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592021148 catalytic residue [active] 216592021149 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 3.5e-84 216592021150 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216592021151 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 216592021152 12 probable transmembrane helices predicted for EC042_4169 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 116-138, 145-167, 177-199, 220-238, 253-275, 296-318, 333-355, 362-384 and 390-412 216592021153 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 216592021154 HMMPfam hit to PF07429, 4-alpha-L-fucosyltransferase (Fuc4NAc, score 4.4e-298 216592021155 putative common antigen polymerase; Provisional; Region: PRK02975 216592021156 HMMPfam hit to PF06899, WzyE protein, score 0 216592021157 11 probable transmembrane helices predicted for EC042_4171 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138, 153-175, 182-201, 205-224, 226-245, 338-360, 381-398 and 408-430 216592021158 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592021159 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 216592021160 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 216592021161 HMMPfam hit to PF03808, Glycosyl transferase WecB/TagA/CpsF f, score 1.9e-89 216592021162 putative transport protein YifK; Provisional; Region: PRK10746 216592021163 HMMPfam hit to PF00324, Amino acid permease, score 1.1e-124 216592021164 12 probable transmembrane helices predicted for EC042_4173 by TMHMM2.0 at aa 19-36, 40-59, 93-115, 125-147, 154-176, 191-213, 240-262, 277-299, 331-353, 358-380, 401-423 and 428-450 216592021165 PS00218 Amino acid permeases signature. 216592021166 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216592021167 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 216592021168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592021169 FeS/SAM binding site; other site 216592021170 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 216592021171 HMMPfam hit to PF04055, Radical SAM superfamily, score 9.6e-15 216592021172 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216592021173 Sulfatase; Region: Sulfatase; pfam00884 216592021174 HMMPfam hit to PF00884, Sulfatase, score 2.5e-98 216592021175 PS00149 Sulfatases signature 2. 216592021176 PS00523 Sulfatases signature 1. 216592021177 2 probable transmembrane helices predicted for EC042_4176 by TMHMM2.0 at aa 21-43 and 48-65 216592021178 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 216592021179 HemY protein N-terminus; Region: HemY_N; pfam07219 216592021180 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 1.8e-06 216592021181 PS00215 Mitochondrial energy transfer proteins signature. 216592021182 HMMPfam hit to PF07719, Tetratricopeptide repeat, score 0.79 216592021183 HMMPfam hit to PF07219, HemY protein N-terminus, score 1.3e-67 216592021184 2 probable transmembrane helices predicted for EC042_4177 by TMHMM2.0 at aa 5-27 and 40-62 216592021185 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 216592021186 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 216592021187 HMMPfam hit to PF04375, HemX, score 6e-200 216592021188 1 probable transmembrane helix predicted for EC042_4178 by TMHMM2.0 at aa 36-58 216592021189 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 216592021190 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216592021191 active site 216592021192 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 4.2e-81 216592021193 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 216592021194 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 216592021195 domain interfaces; other site 216592021196 active site 216592021197 HMMPfam hit to PF03900, Porphobilinogen deaminase, C-terminal, score 9.7e-38 216592021198 PS00533 Porphobilinogen deaminase cofactor-binding site. 216592021199 HMMPfam hit to PF01379, Porphobilinogen deaminase, dipyrometh, score 1.6e-145 216592021200 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 216592021201 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 216592021202 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 216592021203 HMMPfam hit to PF01295, Adenylate cyclase, class-I, score 0 216592021204 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592021205 PS01092 Adenylate cyclases class-I signature 1. 216592021206 PS01093 Adenylate cyclases class-I signature 2. 216592021207 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 216592021208 putative iron binding site [ion binding]; other site 216592021209 HMMPfam hit to PF01491, Frataxin-like domain, score 8.3e-74 216592021210 Unique to 042, islet, exported proteins 216592021211 1 probable transmembrane helix predicted for EC042_4184 by TMHMM2.0 at aa 7-29 216592021212 DKNYY family; Region: DKNYY; pfam13644 216592021213 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 216592021214 1 probable transmembrane helix predicted for EC042_4186 by TMHMM2.0 at aa 24-46 216592021215 1 probable transmembrane helix predicted for EC042_4187 by TMHMM2.0 at aa 6-28 216592021216 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 216592021217 1 probable transmembrane helix predicted for EC042_4188 by TMHMM2.0 at aa 7-29 216592021218 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592021219 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216592021220 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216592021221 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216592021222 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 2.5e-57 216592021223 PS01326 Diaminopimelate epimerase signature. 216592021224 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 1.1e-54 216592021225 hypothetical protein; Provisional; Region: PRK10963 216592021226 HMMPfam hit to PF04340, Protein of unknown function, DUF484, score 7.8e-126 216592021227 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 216592021228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216592021229 active site 216592021230 DNA binding site [nucleotide binding] 216592021231 Int/Topo IB signature motif; other site 216592021232 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 2.5e-34 216592021233 HMMPfam hit to PF00589, Phage integrase family, score 1.9e-66 216592021234 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 216592021235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592021236 motif II; other site 216592021237 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.4e-23 216592021238 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 216592021239 Part of AAA domain; Region: AAA_19; pfam13245 216592021240 Family description; Region: UvrD_C_2; pfam13538 216592021241 HMMPfam hit to PF00580, UvrD/REP helicase, score 3.8e-230 216592021242 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021243 Uncharacterized conserved protein [Function unknown]; Region: COG1912 216592021244 HMMPfam hit to PF01887, Protein of unknown function DUF62, score 8.9e-174 216592021245 Predicted periplasmic protein [Function unknown]; Region: COG3698 216592021246 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 216592021247 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216592021248 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 216592021249 Cl binding site [ion binding]; other site 216592021250 oligomer interface [polypeptide binding]; other site 216592021251 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 2.5e-103 216592021252 2 probable transmembrane helices predicted for EC042_4196 by TMHMM2.0 at aa 255-273 and 288-310 216592021253 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 216592021254 2 probable transmembrane helices predicted for EC042_4197 by TMHMM2.0 at aa 45-67 and 74-96 216592021255 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592021256 hypothetical protein; Provisional; Region: PRK11371 216592021257 4 probable transmembrane helices predicted for EC042_4198 by TMHMM2.0 at aa 38-56, 60-77, 89-111 and 121-140 216592021258 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 216592021259 EamA-like transporter family; Region: EamA; cl17759 216592021260 10 probable transmembrane helices predicted for EC042_4199 by TMHMM2.0 at aa 12-34, 38-60, 73-95, 100-122, 129-146, 150-167, 180-197, 212-234, 239-261 and 271-290 216592021261 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.4e-11 216592021262 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216592021263 CoenzymeA binding site [chemical binding]; other site 216592021264 subunit interaction site [polypeptide binding]; other site 216592021265 PHB binding site; other site 216592021266 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.2e-13 216592021267 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 216592021268 dimerization interface [polypeptide binding]; other site 216592021269 substrate binding site [chemical binding]; other site 216592021270 active site 216592021271 calcium binding site [ion binding]; other site 216592021272 HMMPfam hit to PF02253, Phospholipase A1, score 1.5e-173 216592021273 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 216592021274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592021275 ATP binding site [chemical binding]; other site 216592021276 putative Mg++ binding site [ion binding]; other site 216592021277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592021278 nucleotide binding region [chemical binding]; other site 216592021279 ATP-binding site [chemical binding]; other site 216592021280 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 216592021281 Helicase and RNase D C-terminal; Region: HRDC; smart00341 216592021282 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.8e-34 216592021283 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 7.6e-30 216592021284 HMMPfam hit to PF00570, HRDC domain, score 1.3e-35 216592021285 threonine efflux system; Provisional; Region: PRK10229 216592021286 6 probable transmembrane helices predicted for EC042_4203 by TMHMM2.0 at aa 5-27, 40-62, 67-86, 119-141, 151-173 and 186-205 216592021287 HMMPfam hit to PF01810, LysE type translocator, score 1.5e-76 216592021288 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 216592021289 5 probable transmembrane helices predicted for EC042_4204 by TMHMM2.0 at aa 7-29, 44-66, 115-137, 147-169 and 188-205 216592021290 HMMPfam hit to PF01810, LysE type translocator, score 2.7e-68 216592021291 lysophospholipase L2; Provisional; Region: PRK10749 216592021292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216592021293 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 2.2e-40 216592021294 putative hydrolase; Provisional; Region: PRK10976 216592021295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592021296 active site 216592021297 motif I; other site 216592021298 motif II; other site 216592021299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592021300 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-07 216592021301 PS01228 Hypothetical cof family signature 1. 216592021302 PS01229 Hypothetical cof family signature 2. 216592021303 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216592021304 EamA-like transporter family; Region: EamA; pfam00892 216592021305 10 probable transmembrane helices predicted for EC042_4207 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102, 109-128, 138-157, 170-192, 202-224, 231-253 and 258-275 216592021306 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.5e-11 216592021307 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 216592021308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592021309 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 216592021310 putative dimerization interface [polypeptide binding]; other site 216592021311 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-48 216592021312 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-16 216592021313 PS00044 Bacterial regulatory proteins, lysR family signature. 216592021314 Predicted helix-turn-helix motif with score 1573.000, SD 4.54 at aa 17-38, sequence GSLAAAAATLHQTQSALSHQFS 216592021315 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 216592021316 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 216592021317 THF binding site; other site 216592021318 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 216592021319 substrate binding site [chemical binding]; other site 216592021320 THF binding site; other site 216592021321 zinc-binding site [ion binding]; other site 216592021322 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 inde, score 3.1e-236 216592021323 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216592021324 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 216592021325 HMMPfam hit to PF01738, Dienelactone hydrolase family, score 2.3e-113 216592021326 uridine phosphorylase; Provisional; Region: PRK11178 216592021327 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 216592021328 HMMPfam hit to PF01048, Phosphorylase family, score 5.6e-114 216592021329 PS01232 Purine and other phosphorylases family 1 signature. 216592021330 DNA recombination protein RmuC; Provisional; Region: PRK10361 216592021331 RmuC family; Region: RmuC; pfam02646 216592021332 1 probable transmembrane helix predicted for EC042_4212 by TMHMM2.0 at aa 5-24 216592021333 HMMPfam hit to PF02646, RmuC family, score 9.7e-160 216592021334 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 216592021335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592021336 S-adenosylmethionine binding site [chemical binding]; other site 216592021337 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 4.7e-183 216592021338 PS01183 ubiE/COQ5 methyltransferase family signature 1. 216592021339 PS01184 ubiE/COQ5 methyltransferase family signature 2. 216592021340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 216592021341 SCP-2 sterol transfer family; Region: SCP2; pfam02036 216592021342 HMMPfam hit to PF06843, Protein of unknown function (DUF1243), score 2.2e-96 216592021343 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 216592021344 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 216592021345 HMMPfam hit to PF03109, ABC1 family, score 2.4e-57 216592021346 2 probable transmembrane helices predicted for EC042_4215 by TMHMM2.0 at aa 501-518 and 523-542 216592021347 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 216592021348 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 216592021349 1 probable transmembrane helix predicted for EC042_4216 by TMHMM2.0 at aa 12-34 216592021350 HMMPfam hit to PF02416, mttA/Hcf106 family, score 1.4e-13 216592021351 sec-independent translocase; Provisional; Region: PRK01770 216592021352 sec-independent translocase; Provisional; Region: tatB; PRK00404 216592021353 HMMPfam hit to PF02416, mttA/Hcf106 family, score 0.001 216592021354 1 probable transmembrane helix predicted for EC042_4217 by TMHMM2.0 at aa 4-21 216592021355 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 216592021356 HMMPfam hit to PF00902, Sec-independent protein translocase protein, score 1.7e-99 216592021357 6 probable transmembrane helices predicted for EC042_4218 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-210 and 215-237 216592021358 PS01218 Uncharacterized protein family UPF0032 signature. 216592021359 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216592021360 active site 216592021361 HMMPfam hit to PF01026, TatD related DNase, score 1.9e-106 216592021362 PS01090 Uncharacterized protein family UPF0006 signature 2. 216592021363 PS01091 Uncharacterized protein family UPF0006 signature 3. 216592021364 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 216592021365 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 216592021366 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 216592021367 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 216592021368 HMMPfam hit to PF01977, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 8.2e-257 216592021369 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021370 FMN reductase; Validated; Region: fre; PRK08051 216592021371 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 216592021372 FAD binding pocket [chemical binding]; other site 216592021373 FAD binding motif [chemical binding]; other site 216592021374 phosphate binding motif [ion binding]; other site 216592021375 beta-alpha-beta structure motif; other site 216592021376 NAD binding pocket [chemical binding]; other site 216592021377 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 2.2e-06 216592021378 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.2e-38 216592021379 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 216592021380 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216592021381 dimer interface [polypeptide binding]; other site 216592021382 active site 216592021383 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1.3e-77 216592021384 PS00099 Thiolases active site. 216592021385 PS00737 Thiolases signature 2. 216592021386 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 4.5e-142 216592021387 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592021388 PS00098 Thiolases acyl-enzyme intermediate signature. 216592021389 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 216592021390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216592021391 substrate binding site [chemical binding]; other site 216592021392 oxyanion hole (OAH) forming residues; other site 216592021393 trimer interface [polypeptide binding]; other site 216592021394 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216592021395 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216592021396 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216592021397 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 3.7e-36 216592021398 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 216592021399 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 8.1e-115 216592021400 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 1.3e-87 216592021401 PS00166 Enoyl-CoA hydratase/isomerase signature. 216592021402 proline dipeptidase; Provisional; Region: PRK13607 216592021403 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 216592021404 active site 216592021405 HMMPfam hit to PF00557, metallopeptidase family M24, score 6.6e-118 216592021406 PS00491 Aminopeptidase P and proline dipeptidase signature. 216592021407 hypothetical protein; Provisional; Region: PRK11568 216592021408 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 216592021409 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 216592021410 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 1e-64 216592021411 PS00910 Uncharacterized protein family UPF0029 signature. 216592021412 potassium transporter; Provisional; Region: PRK10750 216592021413 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 216592021414 10 probable transmembrane helices predicted for EC042_4227 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-204, 238-260, 273-295, 332-354, 396-418 and 456-478 216592021415 HMMPfam hit to PF02386, Cation transport protein, score 3.4e-119 216592021416 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 216592021417 PS00201 Flavodoxin signature. 216592021418 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 216592021419 Walker A motif; other site 216592021420 HMMPfam hit to PF03205, Molybdopterin guanine dinucleotide synthesis, score 5.6e-67 216592021421 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021422 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 216592021423 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 216592021424 GTP binding site; other site 216592021425 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 216592021426 HMMPfam hit to PF06288, Protein of unknown function (DUF1040), score 8.5e-63 216592021427 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 216592021428 serine/threonine protein kinase; Provisional; Region: PRK11768 216592021429 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 6.9e-45 216592021430 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 216592021431 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216592021432 catalytic residues [active] 216592021433 hinge region; other site 216592021434 alpha helical domain; other site 216592021435 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.8e-56 216592021436 PS00194 Thioredoxin family active site. 216592021437 hypothetical protein; Provisional; Region: PRK11367 216592021438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 216592021439 HMMPfam hit to PF06097, Bacterial protein of unknown function (DUF94, score 3.2e-302 216592021440 1 probable transmembrane helix predicted for EC042_4234 by TMHMM2.0 at aa 21-40 216592021441 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216592021442 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 216592021443 putative acyl-acceptor binding pocket; other site 216592021444 HMMPfam hit to PF01553, Acyltransferase, score 7.3e-31 216592021445 3 probable transmembrane helices predicted for EC042_4235 by TMHMM2.0 at aa 21-40, 44-61 and 139-157 216592021446 1 probable transmembrane helix predicted for EC042_4236 by TMHMM2.0 at aa 50-69 216592021447 DNA polymerase I; Provisional; Region: PRK05755 216592021448 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216592021449 active site 216592021450 metal binding site 1 [ion binding]; metal-binding site 216592021451 putative 5' ssDNA interaction site; other site 216592021452 metal binding site 3; metal-binding site 216592021453 metal binding site 2 [ion binding]; metal-binding site 216592021454 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216592021455 putative DNA binding site [nucleotide binding]; other site 216592021456 putative metal binding site [ion binding]; other site 216592021457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 216592021458 active site 216592021459 catalytic site [active] 216592021460 substrate binding site [chemical binding]; other site 216592021461 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 216592021462 active site 216592021463 DNA binding site [nucleotide binding] 216592021464 catalytic site [active] 216592021465 HMMPfam hit to PF02739, 5'-3' exonuclease, N-terminal resolvase-, score 8.9e-96 216592021466 HMMPfam hit to PF01367, 5'-3' exonuclease, C-terminal SAM fold, score 2e-55 216592021467 HMMPfam hit to PF01612, 3'-5' exonuclease, score 5.3e-70 216592021468 HMMPfam hit to PF00476, DNA polymerase family A, score 1.9e-239 216592021469 PS00447 DNA polymerase family A signature. 216592021470 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 216592021471 G1 box; other site 216592021472 GTP/Mg2+ binding site [chemical binding]; other site 216592021473 Switch I region; other site 216592021474 G2 box; other site 216592021475 G3 box; other site 216592021476 Switch II region; other site 216592021477 G4 box; other site 216592021478 G5 box; other site 216592021479 HMMPfam hit to PF01926, GTPase of unknown function, score 4.8e-28 216592021480 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 216592021482 HMMPfam hit to PF04220, Protein of unknown function, DUF414, score 1.5e-105 216592021483 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 216592021484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592021485 FeS/SAM binding site; other site 216592021486 HemN C-terminal domain; Region: HemN_C; pfam06969 216592021487 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.1e-24 216592021488 HMMPfam hit to PF06969, HemN C-terminal region, score 5.2e-55 216592021489 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 216592021490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592021491 active site 216592021492 phosphorylation site [posttranslational modification] 216592021493 intermolecular recognition site; other site 216592021494 dimerization interface [polypeptide binding]; other site 216592021495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592021496 Walker A motif; other site 216592021497 ATP binding site [chemical binding]; other site 216592021498 Walker B motif; other site 216592021499 arginine finger; other site 216592021500 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592021501 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 3.3e-16 216592021502 Predicted helix-turn-helix motif with score 1763.000, SD 5.19 at aa 463-484, sequence GHKQEAARLLGWGRNTLTRKLK 216592021503 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592021504 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 3.5e-147 216592021505 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592021506 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592021507 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-40 216592021508 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 216592021509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216592021510 putative active site [active] 216592021511 heme pocket [chemical binding]; other site 216592021512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592021513 dimer interface [polypeptide binding]; other site 216592021514 phosphorylation site [posttranslational modification] 216592021515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592021516 ATP binding site [chemical binding]; other site 216592021517 Mg2+ binding site [ion binding]; other site 216592021518 G-X-G motif; other site 216592021519 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.1e-31 216592021520 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.7e-15 216592021521 glutamine synthetase; Provisional; Region: glnA; PRK09469 216592021522 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216592021523 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216592021524 PS00182 Glutamine synthetase class-I adenylation site. 216592021525 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 1.7e-174 216592021526 PS00181 Glutamine synthetase putative ATP-binding region signature. 216592021527 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp domain, score 2e-48 216592021528 PS00180 Glutamine synthetase signature 1. 216592021529 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 216592021530 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 216592021531 G1 box; other site 216592021532 putative GEF interaction site [polypeptide binding]; other site 216592021533 GTP/Mg2+ binding site [chemical binding]; other site 216592021534 Switch I region; other site 216592021535 G2 box; other site 216592021536 G3 box; other site 216592021537 Switch II region; other site 216592021538 G4 box; other site 216592021539 G5 box; other site 216592021540 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 216592021541 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 216592021542 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 9.7e-75 216592021543 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021544 PS00301 GTP-binding elongation factors signature. 216592021545 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.3e-13 216592021546 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1e-31 216592021547 transcriptional regulator protein; Region: phnR; TIGR03337 216592021548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592021549 DNA-binding site [nucleotide binding]; DNA binding site 216592021550 UTRA domain; Region: UTRA; pfam07702 216592021551 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 2e-23 216592021552 PS00043 Bacterial regulatory proteins, gntR family signature. 216592021553 Predicted helix-turn-helix motif with score 1141.000, SD 3.07 at aa 31-52, sequence PSERELGELLGIKRMTLRQALL 216592021554 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.7e-20 216592021555 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216592021556 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.3e-20 216592021557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592021558 putative substrate translocation pore; other site 216592021559 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 216592021560 12 probable transmembrane helices predicted for EC042_4247 by TMHMM2.0 at aa 7-25, 45-67, 74-91, 96-118, 138-160, 170-189, 221-243, 248-267, 287-309, 314-336, 352-374 and 384-406 216592021561 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-24 216592021562 Present in 0157, absent in Uropathogenic, sugar transport and utilization operon 216592021563 outer membrane porin L; Provisional; Region: ompL; PRK09980 216592021564 HMMPfam hit to PF06178, Oligogalacturonate-specific porin protein (K, score 1.8e-115 216592021565 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 216592021566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592021567 putative substrate translocation pore; other site 216592021568 11 probable transmembrane helices predicted for EC042_4249 by TMHMM2.0 at aa 20-39, 54-76, 88-110, 120-142, 163-182, 186-208, 273-295, 305-323, 330-352, 381-403 and 416-438 216592021569 PS00872 Sodium:galactoside symporter family signature. 216592021570 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 216592021571 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 216592021572 11 probable transmembrane helices predicted for EC042_4250 by TMHMM2.0 at aa 47-69, 90-112, 122-144, 157-179, 189-211, 245-267, 277-296, 309-329, 334-356, 388-410 and 420-442 216592021573 PS00872 Sodium:galactoside symporter family signature. 216592021574 alpha-glucosidase; Provisional; Region: PRK10426 216592021575 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 216592021576 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 216592021577 putative active site [active] 216592021578 putative catalytic site [active] 216592021579 HMMPfam hit to PF01055, Glycosyl hydrolases family, score 1.7e-112 216592021580 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216592021581 9 probable transmembrane helices predicted for EC042_4252 by TMHMM2.0 at aa 20-42, 47-69, 84-106, 113-135, 139-161, 174-196, 200-222, 234-251 and 255-277 216592021582 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 9.5e-26 216592021583 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 216592021584 active site 216592021585 catalytic residues [active] 216592021586 HMMPfam hit to PF01263, Aldose 1-epimerase, score 4.9e-69 216592021587 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 216592021588 dimerization interface [polypeptide binding]; other site 216592021589 putative active cleft [active] 216592021590 HMMPfam hit to PF07221, N-acylglucosamine 2-epimerase (GlcNAc, score 1.2e-198 216592021591 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 216592021592 catalytic residue [active] 216592021593 HMMPfam hit to PF04274, Tagatose 1,6-diphosphate aldolase, (LacD), score 1.7e-139 216592021594 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 216592021595 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216592021596 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 0.0024 216592021597 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 216592021598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592021599 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 216592021600 substrate binding site [chemical binding]; other site 216592021601 ATP binding site [chemical binding]; other site 216592021602 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.6e-78 216592021603 PS00584 pfkB family of carbohydrate kinases signature 2. 216592021604 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216592021605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592021606 putative DNA binding site [nucleotide binding]; other site 216592021607 putative Zn2+ binding site [ion binding]; other site 216592021608 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592021609 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.7e-119 216592021610 PS00894 Bacterial regulatory proteins, deoR family signature. 216592021611 Predicted helix-turn-helix motif with score 1795.000, SD 5.30 at aa 25-46, sequence MNIDELANLLDVSTQTVRRDIR 216592021612 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 216592021613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592021614 motif II; other site 216592021615 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.1e-24 216592021616 hypothetical protein; Reviewed; Region: PRK01637 216592021617 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 5.3e-94 216592021618 6 probable transmembrane helices predicted for EC042_4260 by TMHMM2.0 at aa 39-61, 101-120, 141-163, 183-205, 212-234 and 244-266 216592021619 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592021620 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 216592021621 putative active site [active] 216592021622 dimerization interface [polypeptide binding]; other site 216592021623 putative tRNAtyr binding site [nucleotide binding]; other site 216592021624 HMMPfam hit to PF02580, D-Tyr-tRNA(Tyr) deacylase, score 1.1e-79 216592021625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592021626 Coenzyme A binding pocket [chemical binding]; other site 216592021627 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 216592021628 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.4e-16 216592021629 Predicted helix-turn-helix motif with score 1295.000, SD 3.60 at aa 107-128, sequence MTLESVARQEGVKRVTCSARED 216592021630 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 216592021631 HMMPfam hit to PF01402, Ribbon-helix-helix protein, copG family, score 2.4e-12 216592021632 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 216592021633 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 216592021634 HMMPfam hit to PF04216, Protein involved in formate dehydrogenase fo, score 6.3e-221 216592021635 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 216592021636 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 216592021637 HMMPfam hit to PF01292, Cytochrome b561 family, score 0.00032 216592021638 4 probable transmembrane helices predicted for EC042_4266 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173 216592021639 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 216592021640 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 216592021641 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.5e-05 216592021642 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592021643 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 216592021644 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 216592021645 [4Fe-4S] binding site [ion binding]; other site 216592021646 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216592021647 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 216592021648 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 216592021649 molybdopterin cofactor binding site; other site 216592021650 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.6e-42 216592021651 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592021652 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.4e-06 216592021653 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 9.3e-23 216592021654 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592021655 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 216592021656 HMMPfam hit to PF02634, FdhD/NarQ family, score 1.5e-154 216592021657 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 216592021658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592021659 PS00037 Myb DNA-binding domain repeat signature 1. 216592021660 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 216592021661 HMMPfam hit to PF05336, Protein of unknown function (DUF718), score 6.3e-60 216592021662 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 216592021663 intersubunit interface [polypeptide binding]; other site 216592021664 active site 216592021665 Zn2+ binding site [ion binding]; other site 216592021666 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 1.1e-29 216592021667 L-rhamnose isomerase; Provisional; Region: PRK01076 216592021668 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 216592021669 HMMPfam hit to PF06134, L-rhamnose isomerase (RhaA), score 0 216592021670 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 216592021671 N- and C-terminal domain interface [polypeptide binding]; other site 216592021672 active site 216592021673 putative catalytic site [active] 216592021674 metal binding site [ion binding]; metal-binding site 216592021675 ATP binding site [chemical binding]; other site 216592021676 rhamnulokinase; Provisional; Region: rhaB; PRK10640 216592021677 carbohydrate binding site [chemical binding]; other site 216592021678 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 2.6e-12 216592021679 transcriptional activator RhaS; Provisional; Region: PRK13503 216592021680 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216592021681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592021682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592021683 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 2.8e-31 216592021684 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2e-08 216592021685 Predicted helix-turn-helix motif with score 1331.000, SD 3.72 at aa 188-209, sequence VNWDAVADQFSLSLRTLHRQLK 216592021686 PS00041 Bacterial regulatory proteins, araC family signature. 216592021687 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 3.1e-14 216592021688 transcriptional activator RhaR; Provisional; Region: PRK13500 216592021689 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216592021690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592021691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592021692 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 5e-30 216592021693 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 1.2e-05 216592021694 PS00041 Bacterial regulatory proteins, araC family signature. 216592021695 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 6.7e-14 216592021696 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 216592021697 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 216592021698 HMMPfam hit to PF06379, L-rhamnose-proton symport protein (RhaT), score 8.4e-284 216592021699 10 probable transmembrane helices predicted for EC042_4280 by TMHMM2.0 at aa 4-26, 38-60, 70-92, 99-121, 136-155, 175-192, 212-234, 254-276, 291-310 and 323-342 216592021700 superoxide dismutase; Provisional; Region: PRK10925 216592021701 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216592021702 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216592021703 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 2.5e-54 216592021704 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 1.5e-68 216592021705 PS00088 Manganese and iron superoxide dismutases signature. 216592021706 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 216592021707 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 1.8e-255 216592021708 10 probable transmembrane helices predicted for EC042_4282 by TMHMM2.0 at aa 13-30, 40-62, 75-97, 107-129, 142-164, 168-187, 194-211, 221-243, 255-277 and 287-309 216592021709 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 216592021710 MOSC domain; Region: MOSC; pfam03473 216592021711 3-alpha domain; Region: 3-alpha; pfam03475 216592021712 HMMPfam hit to PF03473, MOSC domain, score 1.9e-48 216592021713 HMMPfam hit to PF03475, 3-alpha domain, score 3.3e-18 216592021714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592021715 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592021716 Helix-turn-helix domain; Region: HTH_28; pfam13518 216592021717 Predicted helix-turn-helix motif with score 1343.000, SD 3.76 at aa 20-41, sequence AGIISTAKLFQLSHTSLSHWIN 216592021718 HTH-like domain; Region: HTH_21; pfam13276 216592021719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216592021720 Integrase core domain; Region: rve; pfam00665 216592021721 Integrase core domain; Region: rve_2; pfam13333 216592021722 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021723 HMMPfam hit to PF00665, Integrase core domain, score 7.6e-45 216592021724 two-component sensor protein; Provisional; Region: cpxA; PRK09470 216592021725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592021726 dimerization interface [polypeptide binding]; other site 216592021727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592021728 dimer interface [polypeptide binding]; other site 216592021729 phosphorylation site [posttranslational modification] 216592021730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592021731 ATP binding site [chemical binding]; other site 216592021732 Mg2+ binding site [ion binding]; other site 216592021733 G-X-G motif; other site 216592021734 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.8e-38 216592021735 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2e-17 216592021736 HMMPfam hit to PF00672, HAMP domain, score 3.2e-14 216592021737 2 probable transmembrane helices predicted for EC042_4286 by TMHMM2.0 at aa 5-27 and 165-187 216592021738 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 216592021739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592021740 active site 216592021741 intermolecular recognition site; other site 216592021742 dimerization interface [polypeptide binding]; other site 216592021743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592021744 DNA binding site [nucleotide binding] 216592021745 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 9.6e-23 216592021746 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-39 216592021747 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 216592021748 dimer interface [polypeptide binding]; other site 216592021749 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 216592021750 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216592021751 HMMPfam hit to PF01545, Cation efflux family, score 6.1e-110 216592021752 6 probable transmembrane helices predicted for EC042_4289 by TMHMM2.0 at aa 20-39, 44-66, 86-108, 123-145, 164-181 and 186-205 216592021753 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 216592021754 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 216592021755 active site 216592021756 ADP/pyrophosphate binding site [chemical binding]; other site 216592021757 dimerization interface [polypeptide binding]; other site 216592021758 allosteric effector site; other site 216592021759 fructose-1,6-bisphosphate binding site; other site 216592021760 HMMPfam hit to PF00365, Phosphofructokinase, score 1.8e-195 216592021761 PS00433 Phosphofructokinase signature. 216592021762 sulfate transporter subunit; Provisional; Region: PRK10752 216592021763 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216592021764 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.4e-14 216592021765 PS00401 Prokaryotic sulfate-binding proteins signature 1. 216592021766 PS00757 Prokaryotic sulfate-binding proteins signature 2. 216592021767 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 216592021768 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, score 2.7e-189 216592021769 1 probable transmembrane helix predicted for EC042_4292 by TMHMM2.0 at aa 69-88 216592021770 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216592021771 triosephosphate isomerase; Provisional; Region: PRK14567 216592021772 substrate binding site [chemical binding]; other site 216592021773 dimer interface [polypeptide binding]; other site 216592021774 catalytic triad [active] 216592021775 HMMPfam hit to PF00121, Triosephosphate isomerase, score 3.3e-161 216592021776 PS00171 Triosephosphate isomerase active site. 216592021777 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021778 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 216592021779 HMMPfam hit to PF07305, Protein of unknown function (DUF1454), score 3.7e-167 216592021780 Predicted membrane protein [Function unknown]; Region: COG3152 216592021781 HMMPfam hit to PF05656, Protein of unknown function (DUF805), score 2.4e-55 216592021782 4 probable transmembrane helices predicted for EC042_4295 by TMHMM2.0 at aa 20-37, 41-63, 72-94 and 99-121 216592021783 hypothetical protein; Provisional; Region: PRK09981 216592021784 HMMPfam hit to PF04175, Protein of unknown function (DUF406), score 3.8e-56 216592021785 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216592021786 Ligand Binding Site [chemical binding]; other site 216592021787 HMMPfam hit to PF00582, Universal stress protein family, score 4.2e-17 216592021788 ferredoxin-NADP reductase; Provisional; Region: PRK10926 216592021789 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 216592021790 FAD binding pocket [chemical binding]; other site 216592021791 FAD binding motif [chemical binding]; other site 216592021792 phosphate binding motif [ion binding]; other site 216592021793 beta-alpha-beta structure motif; other site 216592021794 NAD binding pocket [chemical binding]; other site 216592021795 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 2.4e-27 216592021796 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 2.9e-05 216592021797 PS00430 TonB-dependent receptor proteins signature 1. 216592021798 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 216592021799 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 216592021800 putative active site [active] 216592021801 HMMPfam hit to PF03320, Bacterial fructose-1,6-bisphosphatase, gl, score 3.4e-251 216592021802 glycerol kinase; Provisional; Region: glpK; PRK00047 216592021803 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 216592021804 N- and C-terminal domain interface [polypeptide binding]; other site 216592021805 active site 216592021806 MgATP binding site [chemical binding]; other site 216592021807 catalytic site [active] 216592021808 metal binding site [ion binding]; metal-binding site 216592021809 glycerol binding site [chemical binding]; other site 216592021810 homotetramer interface [polypeptide binding]; other site 216592021811 homodimer interface [polypeptide binding]; other site 216592021812 FBP binding site [chemical binding]; other site 216592021813 protein IIAGlc interface [polypeptide binding]; other site 216592021814 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 5.1e-112 216592021815 PS00445 FGGY family of carbohydrate kinases signature 2. 216592021816 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.2e-141 216592021817 PS00933 FGGY family of carbohydrate kinases signature 1. 216592021818 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 216592021819 amphipathic channel; other site 216592021820 Asn-Pro-Ala signature motifs; other site 216592021821 HMMPfam hit to PF00230, Major intrinsic protein, score 8.5e-137 216592021822 6 probable transmembrane helices predicted for EC042_4301 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 143-165, 178-200 and 229-251 216592021823 PS00221 MIP family signature. 216592021824 septal ring assembly protein ZapB; Provisional; Region: PRK15422 216592021825 HMMPfam hit to PF06005, Protein of unknown function (DUF904), score 4.7e-42 216592021826 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 216592021827 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 2.1e-77 216592021828 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 216592021829 UbiA prenyltransferase family; Region: UbiA; pfam01040 216592021830 9 probable transmembrane helices predicted for EC042_4304 by TMHMM2.0 at aa 24-43, 48-67, 102-121, 125-147, 154-176, 181-203, 232-251, 255-274 and 294-311 216592021831 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 4.6e-54 216592021832 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 216592021833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592021834 Walker A motif; other site 216592021835 ATP binding site [chemical binding]; other site 216592021836 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 216592021837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216592021838 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.1e-06 216592021839 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 3.9e-55 216592021840 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021841 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 216592021842 active site 216592021843 HslU subunit interaction site [polypeptide binding]; other site 216592021844 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 9.3e-46 216592021845 essential cell division protein FtsN; Provisional; Region: PRK10927 216592021846 cell division protein FtsN; Provisional; Region: PRK12757 216592021847 HMMPfam hit to PF05036, Sporulation related repeat, score 1.9e-08 216592021848 HMMPfam hit to PF05036, Sporulation related repeat, score 5.3e-10 216592021849 1 probable transmembrane helix predicted for EC042_4307 by TMHMM2.0 at aa 29-51 216592021850 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592021851 DNA binding site [nucleotide binding] 216592021852 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 216592021853 domain linker motif; other site 216592021854 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 216592021855 dimerization interface [polypeptide binding]; other site 216592021856 ligand binding site [chemical binding]; other site 216592021857 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 7e-28 216592021858 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.3e-10 216592021859 Predicted helix-turn-helix motif with score 1497.000, SD 4.29 at aa 10-31, sequence ATMKDVALKAKVSTATVSRALM 216592021860 PS00356 Bacterial regulatory proteins, lacI family signature. 216592021861 primosome assembly protein PriA; Validated; Region: PRK05580 216592021862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592021863 ATP binding site [chemical binding]; other site 216592021864 putative Mg++ binding site [ion binding]; other site 216592021865 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216592021866 ATP-binding site [chemical binding]; other site 216592021867 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.7e-07 216592021868 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.5e-28 216592021869 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.8e-08 216592021870 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021871 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 216592021872 HMMPfam hit to PF01197, Ribosomal protein L31, score 5.4e-45 216592021873 PS00190 Cytochrome c family heme-binding site signature. 216592021874 PS01143 Ribosomal protein L31 signature. 216592021875 hypothetical protein; Provisional; Region: PRK10030 216592021876 HMMPfam hit to PF06520, Protein of unknown function (DUF1105), score 2.4e-132 216592021877 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 216592021878 dimerization interface [polypeptide binding]; other site 216592021879 DNA binding site [nucleotide binding] 216592021880 corepressor binding sites; other site 216592021881 HMMPfam hit to PF01340, Met Apo-repressor, MetJ, score 9.8e-89 216592021882 cystathionine gamma-synthase; Provisional; Region: PRK08045 216592021883 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216592021884 homodimer interface [polypeptide binding]; other site 216592021885 substrate-cofactor binding pocket; other site 216592021886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592021887 catalytic residue [active] 216592021888 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 6.5e-225 216592021889 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 216592021890 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 216592021891 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 216592021892 putative catalytic residues [active] 216592021893 putative nucleotide binding site [chemical binding]; other site 216592021894 putative aspartate binding site [chemical binding]; other site 216592021895 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 216592021896 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216592021897 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216592021898 HMMPfam hit to PF00696, Amino acid kinase family, score 1.9e-49 216592021899 PS00324 Aspartokinase signature. 216592021900 Predicted helix-turn-helix motif with score 1063.000, SD 2.81 at aa 212-233, sequence YSATQIGALAGVSRVTIWSDVA 216592021901 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 1.8e-55 216592021902 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 1.8e-109 216592021903 PS01042 Homoserine dehydrogenase signature. 216592021904 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 216592021905 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 216592021906 active site 216592021907 metal binding site [ion binding]; metal-binding site 216592021908 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216592021909 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 8e-16 216592021910 PS00786 5'-nucleotidase signature 2. 216592021911 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.3e-48 216592021912 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592021913 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 216592021914 FAD binding site [chemical binding]; other site 216592021915 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 3.4e-160 216592021916 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 216592021917 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 216592021918 heme binding site [chemical binding]; other site 216592021919 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 216592021920 HMMPfam hit to PF00141, Peroxidase, score 4.1e-86 216592021921 PS00436 Peroxidases active site signature. 216592021922 PS00435 Peroxidases proximal heme-ligand signature. 216592021923 PS00017 ATP/GTP-binding site motif A (P-loop). 216592021924 HMMPfam hit to PF00141, Peroxidase, score 2.9e-109 216592021925 EamA-like transporter family; Region: EamA; pfam00892 216592021926 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216592021927 EamA-like transporter family; Region: EamA; pfam00892 216592021928 10 probable transmembrane helices predicted for EC042_4319 by TMHMM2.0 at aa 21-38, 48-70, 83-102, 112-131, 138-155, 165-187, 194-216, 226-248, 255-277 and 281-300 216592021929 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.9e-27 216592021930 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.2e-33 216592021931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 216592021932 HMMPfam hit to PF06940, Protein of unknown function (DUF1287), score 8.7e-144 216592021933 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 216592021934 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 216592021935 dimer interface [polypeptide binding]; other site 216592021936 active site 216592021937 metal binding site [ion binding]; metal-binding site 216592021938 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.2e-82 216592021939 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216592021940 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592021941 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216592021942 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 216592021943 active site 216592021944 intersubunit interactions; other site 216592021945 catalytic residue [active] 216592021946 HMMPfam hit to PF00923, Transaldolase, score 3.4e-102 216592021947 PS00958 Transaldolase active site. 216592021948 PS01054 Transaldolase signature 1. 216592021949 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216592021950 dimerization domain swap beta strand [polypeptide binding]; other site 216592021951 regulatory protein interface [polypeptide binding]; other site 216592021952 active site 216592021953 regulatory phosphorylation site [posttranslational modification]; other site 216592021954 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216592021955 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216592021956 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216592021957 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216592021958 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592021959 active site 216592021960 phosphorylation site [posttranslational modification] 216592021961 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar p, score 2e-10 216592021962 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 2.2e-177 216592021963 PS00742 PEP-utilizing enzymes signature 2. 216592021964 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 9e-23 216592021965 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216592021966 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 0.00088 216592021967 HMMPfam hit to PF00381, PTS HPr component phosphorylation sit, score 3.8e-06 216592021968 PS00369 PTS HPR component histidine phosphorylation site signature. 216592021969 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 216592021970 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 216592021971 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 8.3e-29 216592021972 8 probable transmembrane helices predicted for EC042_4324 by TMHMM2.0 at aa 25-47, 67-89, 102-124, 139-161, 182-201, 221-243, 290-312 and 322-341 216592021973 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 216592021974 active site 216592021975 P-loop; other site 216592021976 phosphorylation site [posttranslational modification] 216592021977 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 6.8e-65 216592021978 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 216592021979 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 216592021980 dimer interface [polypeptide binding]; other site 216592021981 active site 216592021982 glycine loop; other site 216592021983 HMMPfam hit to PF02901, Pyruvate formate lyase, score 0 216592021984 HMMPfam hit to PF01228, Glycine radical, score 1.5e-45 216592021985 PS00850 Glycine radical signature. 216592021986 pyruvate formate lyase II activase; Provisional; Region: PRK10076 216592021987 PS01087 Radical activating enzymes signature. 216592021988 HMMPfam hit to PF04055, Radical SAM superfamily, score 4.6e-15 216592021989 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 216592021990 active site 216592021991 P-loop; other site 216592021992 phosphorylation site [posttranslational modification] 216592021993 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 9.1e-58 216592021994 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592021995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592021996 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.8e-14 216592021997 PS00041 Bacterial regulatory proteins, araC family signature. 216592021998 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 6.8e-07 216592021999 Predicted helix-turn-helix motif with score 1877.000, SD 5.58 at aa 186-207, sequence LTRESVAQAFYISPNYLSHLFQ 216592022000 hypothetical protein; Provisional; Region: PRK10649 216592022001 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 216592022002 Sulfatase; Region: Sulfatase; pfam00884 216592022003 HMMPfam hit to PF00884, Sulfatase, score 5.3e-93 216592022004 4 probable transmembrane helices predicted for EC042_4330 by TMHMM2.0 at aa 31-53, 85-107, 133-155 and 168-185 216592022005 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 216592022006 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 216592022007 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 1.6e-227 216592022008 PS00393 Phosphoenolpyruvate carboxylase active site 2. 216592022009 PS00781 Phosphoenolpyruvate carboxylase active site 1. 216592022010 acetylornithine deacetylase; Provisional; Region: PRK05111 216592022011 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 216592022012 metal binding site [ion binding]; metal-binding site 216592022013 putative dimer interface [polypeptide binding]; other site 216592022014 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.3e-35 216592022015 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 4.8e-33 216592022016 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 216592022017 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216592022018 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 216592022019 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216592022020 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 4.3e-62 216592022021 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592022022 PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 216592022023 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 1.3e-43 216592022024 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 216592022025 nucleotide binding site [chemical binding]; other site 216592022026 N-acetyl-L-glutamate binding site [chemical binding]; other site 216592022027 HMMPfam hit to PF00696, Amino acid kinase family, score 1.5e-46 216592022028 argininosuccinate lyase; Provisional; Region: PRK04833 216592022029 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 216592022030 active sites [active] 216592022031 tetramer interface [polypeptide binding]; other site 216592022032 HMMPfam hit to PF00206, Lyase, score 8.9e-146 216592022033 PS00163 Fumarate lyases signature. 216592022034 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 216592022035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592022036 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 216592022037 dimerization interface [polypeptide binding]; other site 216592022038 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.9e-21 216592022039 Predicted helix-turn-helix motif with score 1674.000, SD 4.89 at aa 16-37, sequence RHFRRAADSCHVSQPTLSGQIR 216592022040 PS00044 Bacterial regulatory proteins, lysR family signature. 216592022041 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-59 216592022042 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 216592022043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216592022044 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216592022045 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 1.1e-38 216592022046 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 8.7e-51 216592022047 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 216592022048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592022049 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 1.2e-11 216592022050 Predicted helix-turn-helix motif with score 1809.000, SD 5.35 at aa 79-100, sequence LSLREVAREAGIAPTSFYRHFR 216592022051 hypothetical protein; Provisional; Region: PRK11056 216592022052 HMMPfam hit to PF07226, Protein of unknown function (DUF1422), score 2.1e-85 216592022053 4 probable transmembrane helices predicted for EC042_4339 by TMHMM2.0 at aa 9-28, 32-50, 62-84 and 89-108 216592022054 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 216592022055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592022056 S-adenosylmethionine binding site [chemical binding]; other site 216592022057 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 3.5e-282 216592022058 PS01231 RNA methyltransferase trmA family signature 2. 216592022059 PS01230 RNA methyltransferase trmA family signature 1. 216592022060 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 216592022061 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592022062 N-terminal plug; other site 216592022063 ligand-binding site [chemical binding]; other site 216592022064 PS00430 TonB-dependent receptor proteins signature 1. 216592022065 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 6.2e-27 216592022066 HMMPfam hit to PF00593, TonB dependent receptor, score 8.7e-26 216592022067 PS01156 TonB-dependent receptor proteins signature 2. 216592022068 glutamate racemase; Provisional; Region: PRK00865 216592022069 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 1.3e-90 216592022070 PS00923 Aspartate and glutamate racemases signature 1. 216592022071 PS00924 Aspartate and glutamate racemases signature 2. 216592022072 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 216592022073 FAD binding domain; Region: FAD_binding_4; pfam01565 216592022074 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 216592022075 HMMPfam hit to PF01565, FAD binding domain, score 8.6e-16 216592022076 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine red, score 3e-77 216592022077 Biotin operon repressor [Transcription]; Region: BirA; COG1654 216592022078 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 216592022079 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 216592022080 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 216592022081 Predicted helix-turn-helix motif with score 1652.000, SD 4.81 at aa 20-41, sequence HSGEQLGETLGMSRAAINKHIQ 216592022082 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 9e-41 216592022083 HMMPfam hit to PF02237, Biotin protein ligase C terminal domain, score 7.8e-11 216592022084 pantothenate kinase; Provisional; Region: PRK05439 216592022085 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 216592022086 ATP-binding site [chemical binding]; other site 216592022087 CoA-binding site [chemical binding]; other site 216592022088 Mg2+-binding site [ion binding]; other site 216592022089 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2.9e-07 216592022090 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022091 elongation factor Tu; Reviewed; Region: PRK00049 216592022092 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216592022093 G1 box; other site 216592022094 GEF interaction site [polypeptide binding]; other site 216592022095 GTP/Mg2+ binding site [chemical binding]; other site 216592022096 Switch I region; other site 216592022097 G2 box; other site 216592022098 G3 box; other site 216592022099 Switch II region; other site 216592022100 G4 box; other site 216592022101 G5 box; other site 216592022102 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216592022103 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216592022104 Antibiotic Binding Site [chemical binding]; other site 216592022105 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3e-97 216592022106 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022107 PS00301 GTP-binding elongation factors signature. 216592022108 HMMPfam hit to PF03144, Elongation factor Tu domain, score 8.6e-26 216592022109 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 1.4e-60 216592022110 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 216592022111 3 probable transmembrane helices predicted for EC042_4348 by TMHMM2.0 at aa 19-36, 40-62 and 94-116 216592022112 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 3.9e-26 216592022113 PS01067 Protein secE/sec61-gamma signature. 216592022114 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 216592022115 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 216592022116 putative homodimer interface [polypeptide binding]; other site 216592022117 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 216592022118 heterodimer interface [polypeptide binding]; other site 216592022119 homodimer interface [polypeptide binding]; other site 216592022120 HMMPfam hit to PF02357, Transcription termination factor nusG, score 5e-24 216592022121 HMMPfam hit to PF00467, KOW motif, score 1.8e-11 216592022122 PS01014 Transcription termination factor nusG signature. 216592022123 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 216592022124 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 216592022125 23S rRNA interface [nucleotide binding]; other site 216592022126 L7/L12 interface [polypeptide binding]; other site 216592022127 putative thiostrepton binding site; other site 216592022128 L25 interface [polypeptide binding]; other site 216592022129 HMMPfam hit to PF03946, Ribosomal protein L11, N-terminal dom, score 1.9e-38 216592022130 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 6.2e-39 216592022131 PS00359 Ribosomal protein L11 signature. 216592022132 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 216592022133 mRNA/rRNA interface [nucleotide binding]; other site 216592022134 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 2.4e-130 216592022135 PS01199 Ribosomal protein L1 signature. 216592022136 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 216592022137 23S rRNA interface [nucleotide binding]; other site 216592022138 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 216592022139 HMMPfam hit to PF00466, Ribosomal protein L10, score 1.9e-39 216592022140 PS01109 Ribosomal protein L10 signature. 216592022141 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 216592022142 core dimer interface [polypeptide binding]; other site 216592022143 peripheral dimer interface [polypeptide binding]; other site 216592022144 L10 interface [polypeptide binding]; other site 216592022145 L11 interface [polypeptide binding]; other site 216592022146 putative EF-Tu interaction site [polypeptide binding]; other site 216592022147 putative EF-G interaction site [polypeptide binding]; other site 216592022148 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 2e-37 216592022149 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 216592022150 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 216592022151 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 216592022152 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216592022153 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 216592022154 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216592022155 RPB3 interaction site [polypeptide binding]; other site 216592022156 RPB1 interaction site [polypeptide binding]; other site 216592022157 RPB11 interaction site [polypeptide binding]; other site 216592022158 RPB10 interaction site [polypeptide binding]; other site 216592022159 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 5.6e-08 216592022160 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain, score 3.4e-06 216592022161 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain, score 9.2e-45 216592022162 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain, score 1.5e-184 216592022163 PS01166 RNA polymerases beta chain signature. 216592022164 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain, score 5.6e-52 216592022165 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 216592022166 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 216592022167 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 216592022168 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 216592022169 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 216592022170 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 216592022171 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216592022172 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 216592022173 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216592022174 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216592022175 DNA binding site [nucleotide binding] 216592022176 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 216592022177 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain, score 5.1e-159 216592022178 HMMPfam hit to PF00623, RNA polymerase Rpb1, domain, score 1.8e-83 216592022179 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain, score 2.3e-52 216592022180 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain, score 2.8e-32 216592022181 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain, score 3e-78 216592022182 stationary phase growth adaptation protein; Provisional; Region: PRK09717 216592022183 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 216592022184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592022185 FeS/SAM binding site; other site 216592022186 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 216592022187 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 1.1e-41 216592022188 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.1e-09 216592022189 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 216592022190 ThiS interaction site; other site 216592022191 putative active site [active] 216592022192 tetramer interface [polypeptide binding]; other site 216592022193 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 1e-177 216592022194 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 216592022195 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 216592022196 ATP binding site [chemical binding]; other site 216592022197 substrate interface [chemical binding]; other site 216592022198 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 5.3e-38 216592022199 HMMPfam hit to PF00899, ThiF family, score 3.2e-58 216592022200 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 216592022201 thiamine phosphate binding site [chemical binding]; other site 216592022202 active site 216592022203 pyrophosphate binding site [ion binding]; other site 216592022204 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 3.4e-101 216592022205 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 216592022206 ThiC-associated domain; Region: ThiC-associated; pfam13667 216592022207 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 216592022208 HMMPfam hit to PF01964, ThiC family, score 0 216592022209 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 216592022210 HMMPfam hit to PF04353, Regulator of RNA polymerase sigma(70) subuni, score 7.5e-115 216592022211 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 216592022212 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 216592022213 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 216592022214 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 216592022215 putative NADH binding site [chemical binding]; other site 216592022216 putative active site [active] 216592022217 nudix motif; other site 216592022218 putative metal binding site [ion binding]; other site 216592022219 HMMPfam hit to PF00293, NUDIX domain, score 2.5e-28 216592022220 PS00893 mutT domain signature. 216592022221 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 216592022222 substrate binding site [chemical binding]; other site 216592022223 active site 216592022224 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 1e-220 216592022225 PS00906 Uroporphyrinogen decarboxylase signature 1. 216592022226 PS00907 Uroporphyrinogen decarboxylase signature 2. 216592022227 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 216592022228 Active_site [active] 216592022229 HMMPfam hit to PF04493, Endonuclease V, score 3e-111 216592022230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 216592022231 HMMPfam hit to PF04222, Protein of unknown function, DUF, score 1.5e-166 216592022232 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216592022233 IHF dimer interface [polypeptide binding]; other site 216592022234 IHF - DNA interface [nucleotide binding]; other site 216592022235 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.1e-50 216592022236 PS00045 Bacterial histone-like DNA-binding proteins signature. 216592022237 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 216592022238 HMMPfam hit to PF07356, Protein of unknown function (DUF1481), score 1.8e-185 216592022239 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592022240 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 216592022241 dimer interface [polypeptide binding]; other site 216592022242 1 probable transmembrane helix predicted for EC042_4369 by TMHMM2.0 at aa 54-76 216592022243 sensor protein ZraS; Provisional; Region: PRK10364 216592022244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592022245 dimer interface [polypeptide binding]; other site 216592022246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592022247 ATP binding site [chemical binding]; other site 216592022248 Mg2+ binding site [ion binding]; other site 216592022249 G-X-G motif; other site 216592022250 2 probable transmembrane helices predicted for EC042_4370 by TMHMM2.0 at aa 10-32 and 190-212 216592022251 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.7e-16 216592022252 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.9e-41 216592022253 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 216592022254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592022255 active site 216592022256 phosphorylation site [posttranslational modification] 216592022257 intermolecular recognition site; other site 216592022258 dimerization interface [polypeptide binding]; other site 216592022259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592022260 Walker A motif; other site 216592022261 ATP binding site [chemical binding]; other site 216592022262 Walker B motif; other site 216592022263 arginine finger; other site 216592022264 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216592022265 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.8e-45 216592022266 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.3e-158 216592022267 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216592022268 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216592022269 PS00688 Sigma-54 interaction domain C-terminal part signature. 216592022270 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 3.7e-15 216592022271 Predicted helix-turn-helix motif with score 1472.000, SD 4.20 at aa 419-440, sequence GNKTEAARQLGITRKTLLAKLS 216592022272 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 216592022273 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 216592022274 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 216592022275 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 216592022276 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C doma, score 1.6e-58 216592022277 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP-gr, score 1.7e-100 216592022278 PS00184 Phosphoribosylglycinamide synthetase signature. 216592022279 HMMPfam hit to PF02842, Phosphoribosylglycinamide synthetase, B doma, score 8.6e-53 216592022280 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N doma, score 1.2e-65 216592022281 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 216592022282 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 216592022283 purine monophosphate binding site [chemical binding]; other site 216592022284 dimer interface [polypeptide binding]; other site 216592022285 putative catalytic residues [active] 216592022286 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 216592022287 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 6.5e-225 216592022288 HMMPfam hit to PF02142, MGS-like domain, score 1.6e-66 216592022289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216592022290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592022291 Coenzyme A binding pocket [chemical binding]; other site 216592022292 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.1e-17 216592022293 homoserine O-succinyltransferase; Provisional; Region: PRK05368 216592022294 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 216592022295 proposed active site lysine [active] 216592022296 conserved cys residue [active] 216592022297 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 6.4e-210 216592022298 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 216592022299 malate synthase A; Region: malate_syn_A; TIGR01344 216592022300 active site 216592022301 HMMPfam hit to PF01274, Malate synthase, score 0 216592022302 PS00510 Malate synthase signature. 216592022303 Predicted helix-turn-helix motif with score 1042.000, SD 2.74 at aa 448-469, sequence YGLMEDAATAEISRTSIWQWIH 216592022304 isocitrate lyase; Provisional; Region: PRK15063 216592022305 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216592022306 tetramer interface [polypeptide binding]; other site 216592022307 active site 216592022308 Mg2+/Mn2+ binding site [ion binding]; other site 216592022309 HMMPfam hit to PF00463, Isocitrate lyase family, score 2.8e-295 216592022310 PS00161 Isocitrate lyase signature. 216592022311 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216592022312 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 216592022313 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 216592022314 HMMPfam hit to PF06315, Isocitrate dehydrogenase kinase/phosphatase, score 0 216592022315 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592022316 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 216592022317 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216592022318 transcriptional repressor IclR; Provisional; Region: PRK11569 216592022319 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216592022320 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592022321 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 7.8e-88 216592022322 PS01051 Bacterial regulatory proteins, iclR family signature. 216592022323 Predicted helix-turn-helix motif with score 1185.000, SD 3.22 at aa 57-78, sequence VALTELAQQAGLPNSTTHRLLT 216592022324 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 216592022325 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 216592022326 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 216592022327 substrate binding pocket [chemical binding]; other site 216592022328 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 216592022329 B12 binding site [chemical binding]; other site 216592022330 cobalt ligand [ion binding]; other site 216592022331 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 216592022332 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 3.6e-168 216592022333 HMMPfam hit to PF00809, Pterin binding enzyme, score 1.7e-79 216592022334 HMMPfam hit to PF02607, B12 binding domain, score 2.1e-49 216592022335 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022336 HMMPfam hit to PF02310, B12 binding domain, score 6.1e-29 216592022337 HMMPfam hit to PF02965, Vitamin B12 dependent methionine synth, score 2.4e-197 216592022338 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 216592022339 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 216592022340 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 216592022341 8 probable transmembrane helices predicted for EC042_4382 by TMHMM2.0 at aa 4-26, 67-89, 99-121, 133-155, 175-194, 201-223, 238-260 and 272-294 216592022342 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 1.8e-64 216592022343 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 216592022344 active site pocket [active] 216592022345 oxyanion hole [active] 216592022346 catalytic triad [active] 216592022347 active site nucleophile [active] 216592022348 HMMPfam hit to PF03575, Peptidase family S51, score 4.2e-79 216592022349 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 216592022350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592022351 putative NAD(P) binding site [chemical binding]; other site 216592022352 catalytic Zn binding site [ion binding]; other site 216592022353 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 6.3e-15 216592022354 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 216592022355 HMMPfam hit to PF03613, PTS system mannose/fructose/sorbose family I, score 6.5e-179 216592022356 4 probable transmembrane helices predicted for EC042_4385 by TMHMM2.0 at aa 134-156, 195-217, 232-254 and 261-283 216592022357 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 216592022358 7 probable transmembrane helices predicted for EC042_4386 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 141-163, 184-202 and 217-239 216592022359 HMMPfam hit to PF03609, PTS system sorbose-specific iic component, score 9.9e-141 216592022360 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 216592022361 active site 216592022362 phosphorylation site [posttranslational modification] 216592022363 HMMPfam hit to PF03830, PTS system sorbose subfamily IIB componen, score 4.2e-90 216592022364 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 216592022365 active pocket/dimerization site; other site 216592022366 active site 216592022367 phosphorylation site [posttranslational modification] 216592022368 HMMPfam hit to PF03610, PTS system fructose IIA component, score 4.8e-33 216592022369 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 216592022370 classical (c) SDRs; Region: SDR_c; cd05233 216592022371 NAD(P) binding site [chemical binding]; other site 216592022372 active site 216592022373 HMMPfam hit to PF00106, short chain dehydrogenase, score 4.9e-87 216592022374 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216592022375 PS00061 Short-chain dehydrogenases/reductases family signature. 216592022376 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216592022377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216592022378 putative DNA binding site [nucleotide binding]; other site 216592022379 putative Zn2+ binding site [ion binding]; other site 216592022380 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216592022381 HMMPfam hit to PF04198, Putative sugar-binding domain, score 6.3e-105 216592022382 Predicted helix-turn-helix motif with score 2409.000, SD 7.39 at aa 50-71, sequence MTQAQIARELGIYRTTISRLLK 216592022383 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 216592022384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216592022385 RNA binding surface [nucleotide binding]; other site 216592022386 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 216592022387 probable active site [active] 216592022388 HMMPfam hit to PF01479, S4 domain, score 3e-15 216592022389 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 7.6e-29 216592022390 PS01149 Rsu family of pseudouridine synthase signature. 216592022391 hypothetical protein; Provisional; Region: PRK10515 216592022392 aspartate kinase III; Validated; Region: PRK09084 216592022393 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 216592022394 nucleotide binding site [chemical binding]; other site 216592022395 substrate binding site [chemical binding]; other site 216592022396 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 216592022397 lysine allosteric regulatory site; other site 216592022398 dimer interface [polypeptide binding]; other site 216592022399 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 216592022400 dimer interface [polypeptide binding]; other site 216592022401 HMMPfam hit to PF01842, ACT domain, score 1e-06 216592022402 HMMPfam hit to PF00696, Amino acid kinase family, score 4.6e-63 216592022403 PS00324 Aspartokinase signature. 216592022404 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 216592022405 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 216592022406 active site 216592022407 dimer interface [polypeptide binding]; other site 216592022408 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 216592022409 dimer interface [polypeptide binding]; other site 216592022410 active site 216592022411 HMMPfam hit to PF00342, Phosphoglucose isomerase, score 0 216592022412 PS00765 Phosphoglucose isomerase signature 1. 216592022413 PS00174 Phosphoglucose isomerase signature 2. 216592022414 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 216592022415 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592022416 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 216592022417 HMMPfam hit to PF06251, Protein of unknown function (DUF1017), score 3.2e-148 216592022418 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 216592022419 HMMPfam hit to PF06082, Bacterial putative lipoprotein (DUF940), score 0 216592022420 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592022421 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 216592022422 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 216592022423 HMMPfam hit to PF06146, Phosphate-starvation-inducible E, score 4.1e-72 216592022424 4 probable transmembrane helices predicted for EC042_4400 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130 216592022425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216592022426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592022427 dimer interface [polypeptide binding]; other site 216592022428 conserved gate region; other site 216592022429 putative PBP binding loops; other site 216592022430 ABC-ATPase subunit interface; other site 216592022431 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-16 216592022432 6 probable transmembrane helices predicted for EC042_4401 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175, 205-227 and 258-280 216592022433 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592022434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592022435 dimer interface [polypeptide binding]; other site 216592022436 conserved gate region; other site 216592022437 putative PBP binding loops; other site 216592022438 ABC-ATPase subunit interface; other site 216592022439 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1e-12 216592022440 8 probable transmembrane helices predicted for EC042_4402 by TMHMM2.0 at aa 17-36, 40-57, 70-92, 284-306, 319-341, 370-392, 413-435 and 484-506 216592022441 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216592022442 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 216592022443 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 216592022444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216592022445 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2.5e-42 216592022446 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 216592022447 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 216592022448 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216592022449 Walker A/P-loop; other site 216592022450 ATP binding site [chemical binding]; other site 216592022451 Q-loop/lid; other site 216592022452 ABC transporter signature motif; other site 216592022453 Walker B; other site 216592022454 D-loop; other site 216592022455 H-loop/switch region; other site 216592022456 TOBE domain; Region: TOBE_2; pfam08402 216592022457 HMMPfam hit to PF00005, ABC transporter, score 3.7e-63 216592022458 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022459 PS00211 ABC transporters family signature. 216592022460 HMMPfam hit to PF03459, TOBE domain, score 1.1e-06 216592022461 HMMPfam hit to PF03459, TOBE domain, score 7.2e-08 216592022462 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 216592022463 trimer interface; other site 216592022464 sugar binding site [chemical binding]; other site 216592022465 HMMPfam hit to PF02264, LamB porin, score 3.8e-236 216592022466 maltose regulon periplasmic protein; Provisional; Region: PRK10564 216592022467 HMMPfam hit to PF07148, Maltose operon periplasmic protein precursor, score 5.2e-194 216592022468 hypothetical protein; Validated; Region: PRK09718 216592022469 SopA-like central domain; Region: SopA; pfam13981 216592022470 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 216592022471 HMMPfam hit to PF04345, Chorismate lyase, score 1.7e-21 216592022472 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022473 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 216592022474 UbiA prenyltransferase family; Region: UbiA; pfam01040 216592022475 7 probable transmembrane helices predicted for EC042_4409 by TMHMM2.0 at aa 23-40, 45-67, 99-132, 160-182, 213-230, 235-252 and 272-289 216592022476 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 7.7e-87 216592022477 PS00943 UbiA prenyltransferase family signature. 216592022478 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 216592022479 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 216592022480 putative acyl-acceptor binding pocket; other site 216592022481 HMMPfam hit to PF01553, Acyltransferase, score 1.2e-42 216592022482 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 216592022483 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 1.9e-69 216592022484 2 probable transmembrane helices predicted for EC042_4411 by TMHMM2.0 at aa 57-79 and 99-121 216592022485 PS01069 Prokaryotic diacylglycerol kinase signature. 216592022486 LexA repressor; Validated; Region: PRK00215 216592022487 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 216592022488 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216592022489 Catalytic site [active] 216592022490 HMMPfam hit to PF01726, LexA DNA binding domain, score 2.7e-41 216592022491 HMMPfam hit to PF00717, Peptidase S24-like, score 1.4e-22 216592022492 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 216592022493 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 216592022494 13 probable transmembrane helices predicted for EC042_4413 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 107-129, 149-171, 178-200, 205-227, 259-281, 285-307, 339-361, 371-393, 406-423 and 427-446 216592022495 HMMPfam hit to PF01554, MatE, score 3.2e-43 216592022496 hypothetical protein; Provisional; Region: PRK10428 216592022497 HMMPfam hit to PF05532, CsbD-like, score 1.5e-24 216592022498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216592022499 metal binding site 2 [ion binding]; metal-binding site 216592022500 putative DNA binding helix; other site 216592022501 metal binding site 1 [ion binding]; metal-binding site 216592022502 dimer interface [polypeptide binding]; other site 216592022503 structural Zn2+ binding site [ion binding]; other site 216592022504 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.9e-06 216592022505 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 216592022506 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 216592022507 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216592022508 FMN binding site [chemical binding]; other site 216592022509 active site 216592022510 catalytic residues [active] 216592022511 substrate binding site [chemical binding]; other site 216592022512 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.5e-148 216592022513 PS01136 Uncharacterized protein family UPF0034 signature. 216592022514 phage shock protein G; Reviewed; Region: pspG; PRK09459 216592022515 2 probable transmembrane helices predicted for EC042_4418 by TMHMM2.0 at aa 61-83 and 98-120 216592022516 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 216592022517 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 216592022518 NADP binding site [chemical binding]; other site 216592022519 dimer interface [polypeptide binding]; other site 216592022520 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 4.9e-82 216592022521 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 216592022522 replicative DNA helicase; Provisional; Region: PRK08006 216592022523 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216592022524 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216592022525 Walker A motif; other site 216592022526 ATP binding site [chemical binding]; other site 216592022527 Walker B motif; other site 216592022528 DNA binding loops [nucleotide binding] 216592022529 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 3e-58 216592022530 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 7.8e-138 216592022531 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022532 Predicted helix-turn-helix motif with score 1557.000, SD 4.49 at aa 366-387, sequence RSLKALAKELNVPVVALSQLNR 216592022533 alanine racemase; Reviewed; Region: alr; PRK00053 216592022534 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 216592022535 active site 216592022536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216592022537 substrate binding site [chemical binding]; other site 216592022538 catalytic residues [active] 216592022539 dimer interface [polypeptide binding]; other site 216592022540 HMMPfam hit to PF01168, Alanine racemase, N-terminal domain, score 1.2e-96 216592022541 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 216592022542 HMMPfam hit to PF00842, Alanine racemase, C-terminal domain, score 1.6e-69 216592022543 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 216592022544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216592022545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592022546 homodimer interface [polypeptide binding]; other site 216592022547 catalytic residue [active] 216592022548 HMMPfam hit to PF00155, Aminotransferase class I and II, score 9.8e-106 216592022549 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216592022550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592022551 active site 216592022552 motif I; other site 216592022553 motif II; other site 216592022554 HMMPfam hit to PF03767, HAD superfamily, subfamily IIIB (Acid, score 5.1e-61 216592022555 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 216592022556 HMMPfam hit to PF01894, Uncharacterised protein family UPF0047, score 3.3e-65 216592022557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 216592022558 HMMPfam hit to PF04237, Protein of unknown function (DUF419), score 2.8e-51 216592022559 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216592022560 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216592022561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216592022562 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 216592022563 HMMPfam hit to PF00005, ABC transporter, score 1.8e-42 216592022564 PS00211 ABC transporters family signature. 216592022565 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022566 PS00211 ABC transporters family signature. 216592022567 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022568 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216592022569 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592022570 dimer interface [polypeptide binding]; other site 216592022571 ssDNA binding site [nucleotide binding]; other site 216592022572 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592022573 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 216592022574 HMMPfam hit to PF00436, Single-strand binding protein family, score 1.2e-38 216592022575 PS00735 Single-strand binding protein family signature 1. 216592022576 PS00736 Single-strand binding protein family signature 2. 216592022577 2 probable transmembrane helices predicted for EC042_4429 by TMHMM2.0 at aa 40-62 and 72-94 216592022578 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 216592022579 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216592022580 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216592022581 2 probable transmembrane helices predicted for EC042_4430 by TMHMM2.0 at aa 10-32 and 239-261 216592022582 HMMPfam hit to PF00563, EAL domain, score 3.8e-116 216592022583 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 216592022584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592022585 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.5e-13 216592022586 PS00041 Bacterial regulatory proteins, araC family signature. 216592022587 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.6e-10 216592022588 Predicted helix-turn-helix motif with score 1180.000, SD 3.21 at aa 22-43, sequence LNIDVVAKKSGYSKWYLQRMFR 216592022589 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 216592022590 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 216592022591 DNA binding residues [nucleotide binding] 216592022592 dimer interface [polypeptide binding]; other site 216592022593 [2Fe-2S] cluster binding site [ion binding]; other site 216592022594 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 12-33, sequence LTPGEVAKRSGVAVSALHFYES 216592022595 HMMPfam hit to PF00376, MerR family regulatory protein, score 7.3e-12 216592022596 PS00552 Bacterial regulatory proteins, merR family signature. 216592022597 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 216592022598 HMMPfam hit to PF00860, Permease family, score 4.1e-112 216592022599 13 probable transmembrane helices predicted for EC042_4434 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 146-165, 175-197, 202-224, 244-266, 307-329, 334-351, 356-378, 393-415 and 428-447 216592022600 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022601 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 216592022602 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216592022603 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 1.6e-130 216592022604 11 probable transmembrane helices predicted for EC042_4435 by TMHMM2.0 at aa 4-21, 28-50, 85-107, 114-136, 159-181, 188-205, 233-255, 276-298, 313-335, 361-383 and 398-420 216592022606 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 0.97 216592022607 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 8.1e-06 216592022608 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 216592022609 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 216592022610 Na binding site [ion binding]; other site 216592022611 13 probable transmembrane helices predicted for EC042_4438 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 146-168, 183-205, 212-234, 261-283, 303-325, 359-381, 402-424, 428-450, 462-484 and 494-516 216592022612 PS00457 Sodium:solute symporter family signature 2. 216592022613 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2.6e-205 216592022614 PS00456 Sodium:solute symporter family signature 1. 216592022615 Predicted membrane protein [Function unknown]; Region: COG3162 216592022616 HMMPfam hit to PF04341, Protein of unknown function, DUF485, score 1.1e-63 216592022617 2 probable transmembrane helices predicted for EC042_4439 by TMHMM2.0 at aa 26-48 and 63-85 216592022618 acetyl-CoA synthetase; Provisional; Region: PRK00174 216592022619 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 216592022620 active site 216592022621 CoA binding site [chemical binding]; other site 216592022622 acyl-activating enzyme (AAE) consensus motif; other site 216592022623 AMP binding site [chemical binding]; other site 216592022624 acetate binding site [chemical binding]; other site 216592022625 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.1e-140 216592022626 PS00455 Putative AMP-binding domain signature. 216592022627 PS00018 EF-hand calcium-binding domain. 216592022628 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 216592022629 HMMPfam hit to PF02335, Cytochrome c552, score 0 216592022630 PS00190 Cytochrome c family heme-binding site signature. 216592022631 PS00190 Cytochrome c family heme-binding site signature. 216592022632 PS00190 Cytochrome c family heme-binding site signature. 216592022633 PS00190 Cytochrome c family heme-binding site signature. 216592022634 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 216592022635 PS00190 Cytochrome c family heme-binding site signature. 216592022636 PS00190 Cytochrome c family heme-binding site signature. 216592022637 PS00190 Cytochrome c family heme-binding site signature. 216592022638 PS00190 Cytochrome c family heme-binding site signature. 216592022639 PS00190 Cytochrome c family heme-binding site signature. 216592022640 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 216592022641 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216592022642 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0003 216592022643 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 8.2e-06 216592022644 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592022645 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.007 216592022646 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 216592022647 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 216592022648 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 2.4e-163 216592022649 8 probable transmembrane helices predicted for EC042_4444 by TMHMM2.0 at aa 15-37, 57-76, 91-113, 151-170, 180-202, 222-241, 256-278 and 290-312 216592022650 heme lyase subunit NrfE; Provisional; Region: PRK10369 216592022651 12 probable transmembrane helices predicted for EC042_4445 by TMHMM2.0 at aa 32-54, 86-105, 112-134, 164-186, 199-221, 236-255, 268-290, 300-322, 343-365, 380-402, 409-431 and 534-553 216592022652 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 3e-78 216592022653 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 216592022654 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 2.3e-44 216592022655 1 probable transmembrane helix predicted for EC042_4446 by TMHMM2.0 at aa 99-121 216592022656 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 216592022657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216592022658 binding surface 216592022659 TPR motif; other site 216592022660 1 probable transmembrane helix predicted for EC042_4447 by TMHMM2.0 at aa 10-29 216592022661 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.00018 216592022662 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 0.8 216592022663 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 216592022664 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216592022665 10 probable transmembrane helices predicted for EC042_4448 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 159-181, 202-224, 234-256, 293-310, 325-347, 354-376 and 391-409 216592022666 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.8e-230 216592022667 PS00713 Sodium:dicarboxylate symporter family signature 1. 216592022668 Predicted helix-turn-helix motif with score 1016.000, SD 2.65 at aa 247-268, sequence VVLGIVARLCGLSVWILIRILK 216592022669 PS00714 Sodium:dicarboxylate symporter family signature 2. 216592022670 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216592022671 Sel1-like repeats; Region: SEL1; smart00671 216592022672 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 216592022673 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 216592022674 [4Fe-4S] binding site [ion binding]; other site 216592022675 molybdopterin cofactor binding site; other site 216592022676 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 216592022677 molybdopterin cofactor binding site; other site 216592022678 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.8e-34 216592022679 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 216592022680 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.5e-114 216592022681 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216592022682 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 6.3e-22 216592022683 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022684 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216592022685 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 216592022686 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.3e-43 216592022687 HMMPfam hit to PF02321, Outer membrane efflux protein, score 0.0011 216592022688 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592022689 PS00443 Glutamine amidotransferases class-II active site. 216592022690 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 216592022691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216592022692 9 probable transmembrane helices predicted for EC042_4453 by TMHMM2.0 at aa 42-64, 71-93, 103-120, 127-146, 156-178, 400-422, 426-445, 452-474 and 484-501 216592022693 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved re, score 5e-47 216592022694 multidrug resistance protein MdtN; Provisional; Region: PRK10476 216592022695 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216592022696 HlyD family secretion protein; Region: HlyD_3; pfam13437 216592022697 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.1e-64 216592022698 1 probable transmembrane helix predicted for EC042_4454 by TMHMM2.0 at aa 13-31 216592022699 3 probable transmembrane helices predicted for EC042_4455 by TMHMM2.0 at aa 32-54, 58-77 and 84-106 216592022700 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 216592022701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216592022702 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592022703 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1e-15 216592022704 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 216592022705 1 probable transmembrane helix predicted for EC042_4457 by TMHMM2.0 at aa 13-35 216592022706 HMMPfam hit to PF02502, Ribose/Galactose Isomerase, score 5.6e-07 216592022707 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 216592022708 putative hydrolase; Provisional; Region: PRK02113 216592022709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592022710 Coenzyme A binding pocket [chemical binding]; other site 216592022711 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.1e-17 216592022712 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 216592022713 Guanylate kinase; Region: Guanylate_kin; pfam00625 216592022714 active site 216592022715 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 216592022716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216592022717 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 216592022718 active site 216592022719 HMMPfam hit to PF01979, Amidohydrolase family, score 0.0033 216592022720 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 216592022721 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216592022722 Walker A/P-loop; other site 216592022723 ATP binding site [chemical binding]; other site 216592022724 Q-loop/lid; other site 216592022725 ABC transporter signature motif; other site 216592022726 Walker B; other site 216592022727 D-loop; other site 216592022728 H-loop/switch region; other site 216592022729 HMMPfam hit to PF00005, ABC transporter, score 6.5e-59 216592022730 PS00211 ABC transporters family signature. 216592022731 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022732 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 216592022733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216592022734 Walker A/P-loop; other site 216592022735 ATP binding site [chemical binding]; other site 216592022736 Q-loop/lid; other site 216592022737 ABC transporter signature motif; other site 216592022738 Walker B; other site 216592022739 D-loop; other site 216592022740 H-loop/switch region; other site 216592022741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216592022742 HMMPfam hit to PF00005, ABC transporter, score 1.4e-64 216592022743 PS00211 ABC transporters family signature. 216592022744 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022745 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 216592022746 HMMPfam hit to PF06007, Phosphonate metabolism protein PhnJ, score 5.5e-239 216592022747 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 216592022748 HMMPfam hit to PF05861, Bacterial phosphonate metabolism protein (Ph, score 5.9e-247 216592022749 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 216592022750 HMMPfam hit to PF05845, Bacterial phosphonate metabolism protein (Ph, score 1.4e-115 216592022751 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 216592022752 HMMPfam hit to PF06754, Phosphonate metabolism protein PhnG, score 1.6e-95 216592022753 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 216592022754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592022755 DNA-binding site [nucleotide binding]; DNA binding site 216592022756 UTRA domain; Region: UTRA; pfam07702 216592022757 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 2e-41 216592022758 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.1e-27 216592022759 PS00043 Bacterial regulatory proteins, gntR family signature. 216592022760 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 216592022761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216592022762 dimer interface [polypeptide binding]; other site 216592022763 conserved gate region; other site 216592022764 putative PBP binding loops; other site 216592022765 ABC-ATPase subunit interface; other site 216592022766 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.4e-25 216592022767 6 probable transmembrane helices predicted for EC042_4470 by TMHMM2.0 at aa 13-32, 70-92, 121-143, 179-196, 203-225 and 229-251 216592022768 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 216592022769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216592022770 substrate binding pocket [chemical binding]; other site 216592022771 membrane-bound complex binding site; other site 216592022772 hinge residues; other site 216592022773 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 216592022774 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 216592022775 Walker A/P-loop; other site 216592022776 ATP binding site [chemical binding]; other site 216592022777 Q-loop/lid; other site 216592022778 ABC transporter signature motif; other site 216592022779 Walker B; other site 216592022780 D-loop; other site 216592022781 H-loop/switch region; other site 216592022782 HMMPfam hit to PF00005, ABC transporter, score 4.6e-71 216592022783 PS00211 ABC transporters family signature. 216592022784 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022785 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216592022786 dimer interface [polypeptide binding]; other site 216592022787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216592022788 hypothetical protein; Provisional; Region: PRK10220 216592022789 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 216592022790 PhnA protein; Region: PhnA; pfam03831 216592022791 HMMPfam hit to PF03831, PhnA protein, score 1.8e-37 216592022792 hypothetical protein; Provisional; Region: PRK09866 216592022793 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216592022794 G1 box; other site 216592022795 GTP/Mg2+ binding site [chemical binding]; other site 216592022796 G2 box; other site 216592022797 Switch I region; other site 216592022798 G3 box; other site 216592022799 Switch II region; other site 216592022800 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 216592022801 G2 box; other site 216592022802 Switch I region; other site 216592022803 G3 box; other site 216592022804 Switch II region; other site 216592022805 G4 box; other site 216592022806 G5 box; other site 216592022807 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022808 YjcZ-like protein; Region: YjcZ; pfam13990 216592022809 proline/glycine betaine transporter; Provisional; Region: PRK10642 216592022810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592022811 putative substrate translocation pore; other site 216592022812 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 216592022813 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2.9e-108 216592022814 12 probable transmembrane helices predicted for EC042_4477 by TMHMM2.0 at aa 41-63, 78-100, 109-128, 132-154, 179-201, 211-228, 271-293, 308-330, 337-357, 362-384, 397-419 and 429-448 216592022815 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.6e-28 216592022816 PS00216 Sugar transport proteins signature 1. 216592022817 sensor protein BasS/PmrB; Provisional; Region: PRK10755 216592022818 HAMP domain; Region: HAMP; pfam00672 216592022819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592022820 dimer interface [polypeptide binding]; other site 216592022821 phosphorylation site [posttranslational modification] 216592022822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592022823 ATP binding site [chemical binding]; other site 216592022824 Mg2+ binding site [ion binding]; other site 216592022825 G-X-G motif; other site 216592022826 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.3e-25 216592022827 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 6.5e-11 216592022828 HMMPfam hit to PF00672, HAMP domain, score 5.8e-08 216592022829 2 probable transmembrane helices predicted for EC042_4478 by TMHMM2.0 at aa 15-37 and 69-91 216592022830 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 216592022831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592022832 active site 216592022833 phosphorylation site [posttranslational modification] 216592022834 intermolecular recognition site; other site 216592022835 dimerization interface [polypeptide binding]; other site 216592022836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592022837 DNA binding site [nucleotide binding] 216592022838 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.6e-19 216592022839 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.5e-44 216592022840 PS00217 Sugar transport proteins signature 2. 216592022841 putative metal dependent hydrolase; Provisional; Region: PRK11598 216592022842 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 216592022843 Sulfatase; Region: Sulfatase; pfam00884 216592022844 HMMPfam hit to PF00884, Sulfatase, score 3.8e-102 216592022845 5 probable transmembrane helices predicted for EC042_4480 by TMHMM2.0 at aa 26-48, 63-88, 93-115, 135-157 and 169-191 216592022846 arginine:agmatin antiporter; Provisional; Region: PRK10644 216592022847 HMMPfam hit to PF00324, Amino acid permease, score 5.3e-12 216592022848 12 probable transmembrane helices predicted for EC042_4481 by TMHMM2.0 at aa 10-32, 39-61, 94-116, 123-142, 152-171, 184-206, 226-248, 275-297, 320-342, 354-376, 386-403 and 410-428 216592022849 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592022850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592022851 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.3e-07 216592022852 PS00041 Bacterial regulatory proteins, araC family signature. 216592022853 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.1e-05 216592022854 Predicted helix-turn-helix motif with score 1218.000, SD 3.34 at aa 163-184, sequence WNLSMVAGCLCLSPSLLKKKLK 216592022855 arginine decarboxylase; Provisional; Region: PRK15029 216592022856 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 216592022857 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 216592022858 homodimer interface [polypeptide binding]; other site 216592022859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592022860 catalytic residue [active] 216592022861 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216592022862 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 2.1e-78 216592022863 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 4.7e-292 216592022864 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 216592022865 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 1.8e-53 216592022866 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 216592022867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592022868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592022869 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.2e-14 216592022870 PS00041 Bacterial regulatory proteins, araC family signature. 216592022871 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 9.6e-06 216592022872 alpha-galactosidase; Provisional; Region: PRK15076 216592022873 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 216592022874 NAD binding site [chemical binding]; other site 216592022875 sugar binding site [chemical binding]; other site 216592022876 divalent metal binding site [ion binding]; other site 216592022877 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592022878 dimer interface [polypeptide binding]; other site 216592022879 HMMPfam hit to PF02056, Family 4 glycosyl hydrolase, score 2.5e-248 216592022880 PS01324 Glycosyl hydrolases family 4 signature. 216592022881 Predicted helix-turn-helix motif with score 1347.000, SD 3.77 at aa 178-199, sequence GTAEELARDLNIDPATLRYRCA 216592022882 hypothetical protein; Provisional; Region: PRK09867 216592022883 6 probable transmembrane helices predicted for EC042_4486 by TMHMM2.0 at aa 7-29, 33-52, 59-81, 104-121, 133-155 and 175-194 216592022884 fumarate hydratase; Provisional; Region: PRK15389 216592022885 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 216592022886 Fumarase C-terminus; Region: Fumerase_C; pfam05683 216592022887 HMMPfam hit to PF05683, Fumarase C-terminus, score 1.9e-113 216592022888 PS00163 Fumarate lyases signature. 216592022889 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 1.1e-150 216592022890 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 216592022891 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 216592022892 11 probable transmembrane helices predicted for EC042_4488 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 142-164, 171-193, 236-253, 266-288, 303-325, 346-368, 378-400 and 421-443 216592022893 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 1.9e-261 216592022894 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 216592022895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592022896 active site 216592022897 phosphorylation site [posttranslational modification] 216592022898 intermolecular recognition site; other site 216592022899 dimerization interface [polypeptide binding]; other site 216592022900 Transcriptional regulator; Region: CitT; pfam12431 216592022901 Predicted helix-turn-helix motif with score 1148.000, SD 3.10 at aa 179-200, sequence FSTDELANEVNISRVSCRKYLI 216592022902 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-17 216592022903 sensory histidine kinase DcuS; Provisional; Region: PRK11086 216592022904 PAS domain; Region: PAS; smart00091 216592022905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592022906 ATP binding site [chemical binding]; other site 216592022907 Mg2+ binding site [ion binding]; other site 216592022908 G-X-G motif; other site 216592022909 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.4e-30 216592022910 HMMPfam hit to PF00989, PAS domain, score 1.1e-11 216592022911 2 probable transmembrane helices predicted for EC042_4490 by TMHMM2.0 at aa 20-42 and 183-205 216592022912 Uncharacterized conserved protein [Function unknown]; Region: COG3592 216592022913 HMMPfam hit to PF06902, Protein of unknown function (DUF1271), score 5.8e-47 216592022914 Predicted acetyltransferase [General function prediction only]; Region: COG2388 216592022915 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 216592022916 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 216592022917 2 probable transmembrane helices predicted for EC042_4494 by TMHMM2.0 at aa 7-24 and 34-56 216592022918 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 216592022919 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216592022920 dimer interface [polypeptide binding]; other site 216592022921 putative anticodon binding site; other site 216592022922 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 216592022923 motif 1; other site 216592022924 active site 216592022925 motif 2; other site 216592022926 motif 3; other site 216592022927 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.7e-208 216592022928 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592022929 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592022930 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.3e-20 216592022931 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 216592022932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592022933 putative substrate translocation pore; other site 216592022934 POT family; Region: PTR2; pfam00854 216592022935 14 probable transmembrane helices predicted for EC042_4496 by TMHMM2.0 at aa 9-31, 46-68, 71-93, 103-125, 138-160, 164-186, 207-229, 234-251, 264-281, 307-329, 341-360, 375-397, 404-426 and 452-474 216592022936 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.1e-10 216592022937 HMMPfam hit to PF00854, POT family, score 4.8e-106 216592022938 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 216592022939 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592022940 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 216592022941 lysine decarboxylase CadA; Provisional; Region: PRK15400 216592022942 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 216592022943 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 216592022944 homodimer interface [polypeptide binding]; other site 216592022945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216592022946 catalytic residue [active] 216592022947 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216592022948 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 1.9e-90 216592022949 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 1.2e-288 216592022950 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 216592022951 PS00237 G-protein coupled receptors signature. 216592022952 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 2.3e-62 216592022953 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 216592022954 HMMPfam hit to PF00324, Amino acid permease, score 2.1e-06 216592022955 12 probable transmembrane helices predicted for EC042_4498 by TMHMM2.0 at aa 7-29, 39-58, 93-115, 120-142, 149-171, 186-208, 220-242, 271-293, 322-344, 354-371, 384-403 and 407-424 216592022956 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 216592022957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592022958 DNA binding site [nucleotide binding] 216592022959 1 probable transmembrane helix predicted for EC042_4499 by TMHMM2.0 at aa 159-181 216592022960 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 1.7e-20 216592022961 Genomic island 3. Absent in 0157, divergent in Uropathogenic, inserted at tRNA, flanked by repeats 216592022962 Methyltransferase domain; Region: Methyltransf_27; pfam13708 216592022963 Herpes virus major capsid protein; Region: Herpes_MCP; pfam03122 216592022964 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 216592022965 HMMPfam hit to PF06117, Enterobacterial protein of unknown function, score 1.2e-47 216592022966 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 216592022967 HMMPfam hit to PF06755, Protein of unknown function (DUF1219), score 6.8e-103 216592022968 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 216592022969 HMMPfam hit to PF06154, YagB/YeeU/YfjZ family, score 1.3e-86 216592022970 Protein of unknown function (DUF987); Region: DUF987; pfam06174 216592022971 HMMPfam hit to PF06174, Protein of unknown function (DUF987), score 3.2e-57 216592022972 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 216592022973 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216592022974 MPN+ (JAMM) motif; other site 216592022975 Zinc-binding site [ion binding]; other site 216592022976 Antirestriction protein; Region: Antirestrict; pfam03230 216592022977 Domain of unknown function (DUF932); Region: DUF932; pfam06067 216592022978 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 1.5e-220 216592022979 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 216592022980 8 probable transmembrane helices predicted for EC042_4510 by TMHMM2.0 at aa 7-24, 29-51, 64-83, 98-115, 136-158, 168-187, 680-702 and 717-739 216592022981 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022982 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592022983 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592022984 hypothetical protein; Provisional; Region: PRK09945 216592022985 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592022986 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592022987 Autotransporter beta-domain; Region: Autotransporter; smart00869 216592022988 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.8e-33 216592022989 HMMPfam hit to PF03212, Pertactin, score 4.4e-06 216592022990 PS00017 ATP/GTP-binding site motif A (P-loop). 216592022991 HMMPfam hit to PF05594, no description, score 4.1 216592022992 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592022993 HMMPfam hit to PF05594, no description, score 8.5 216592022994 Predicted GTPase [General function prediction only]; Region: COG3596 216592022995 YfjP GTPase; Region: YfjP; cd11383 216592022996 G1 box; other site 216592022997 GTP/Mg2+ binding site [chemical binding]; other site 216592022998 Switch I region; other site 216592022999 G2 box; other site 216592023000 Switch II region; other site 216592023001 G3 box; other site 216592023002 G4 box; other site 216592023003 G5 box; other site 216592023004 HMMPfam hit to PF01926, GTPase of unknown function, score 8.6e-20 216592023005 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023006 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 216592023007 PS00818 Dps protein family signature 1. 216592023008 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 216592023009 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 2e-22 216592023010 Haemolysin expression modulating protein; Region: HHA; pfam05321 216592023011 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 8e-32 216592023012 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592023013 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 216592023014 PS00190 Cytochrome c family heme-binding site signature. 216592023015 PS00190 Cytochrome c family heme-binding site signature. 216592023016 This CDS carries a frameshift mutation following codon 5, within a homopolymeric tract 5xA. 216592023017 Predicted helix-turn-helix motif with score 1091.000, SD 2.90 at aa 130-151, sequence LPYQQVAREVKAPRERLKYALE 216592023018 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 216592023019 Type VI secretion system 2 216592023020 Protein of unknown function (DUF770); Region: DUF770; pfam05591 216592023021 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 1.9e-69 216592023022 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 216592023023 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216592023024 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 2.6e-296 216592023025 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 216592023026 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 216592023027 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 2.8e-157 216592023028 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 216592023029 1 probable transmembrane helix predicted for EC042_4527 by TMHMM2.0 at aa 206-228 216592023030 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216592023031 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216592023032 ligand binding site [chemical binding]; other site 216592023033 3 probable transmembrane helices predicted for EC042_4528 by TMHMM2.0 at aa 37-59, 64-81 and 362-379 216592023034 HMMPfam hit to PF00691, OmpA family, score 3.5e-23 216592023035 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 216592023036 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 4.9e-58 216592023037 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 216592023038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023039 Walker A motif; other site 216592023040 ATP binding site [chemical binding]; other site 216592023041 Walker B motif; other site 216592023042 arginine finger; other site 216592023043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023044 Walker A motif; other site 216592023045 ATP binding site [chemical binding]; other site 216592023046 Walker B motif; other site 216592023047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216592023048 HMMPfam hit to PF02861, Clp amino terminal domain, score 0.038 216592023049 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.2e-09 216592023050 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023051 PS00870 Chaperonins clpA/B signature 1. 216592023052 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 5.7e-81 216592023053 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023054 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592023055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023056 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 216592023057 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216592023058 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 216592023059 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 216592023060 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 216592023061 PS00141 Eukaryotic and viral aspartyl proteases active site. 216592023062 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.9e-13 216592023063 Predicted helix-turn-helix motif with score 986.000, SD 2.55 at aa 592-613, sequence RSMAKAATAANATQGDISCQQR 216592023064 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 216592023065 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 216592023066 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023067 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 216592023068 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023069 PAAR motif; Region: PAAR_motif; pfam05488 216592023070 HMMPfam hit to PF05488, PAAR motif, score 5.6e-06 216592023071 HMMPfam hit to PF05488, PAAR motif, score 1.2 216592023072 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 216592023073 2 probable transmembrane helices predicted for EC042_4538 by TMHMM2.0 at aa 20-39 and 52-74 216592023074 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 216592023075 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 216592023076 2 probable transmembrane helices predicted for EC042_4539 by TMHMM2.0 at aa 15-37 and 44-63 216592023077 HMMPfam hit to PF06761, ImcF-related, score 1.5e-71 216592023078 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 1.8e-38 216592023079 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592023080 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 216592023081 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023082 HMMPfam hit to PF06812, ImpA-related N-terminal, score 3.3e-26 216592023083 3 probable transmembrane helices predicted for EC042_4541 by TMHMM2.0 at aa 41-63, 165-187 and 197-219 216592023084 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 216592023085 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 216592023086 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 8.8e-202 216592023087 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 216592023088 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 8.9e-29 216592023089 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 216592023090 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023091 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 216592023092 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 8.6e-29 216592023093 hypothetical protein; Provisional; Region: PRK10040 216592023094 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 216592023095 2 probable transmembrane helices predicted for EC042_4547 by TMHMM2.0 at aa 13-32 and 47-69 216592023096 Nuclease-related domain; Region: NERD; pfam08378 216592023097 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 216592023098 Part of AAA domain; Region: AAA_19; pfam13245 216592023099 Family description; Region: UvrD_C_2; pfam13538 216592023100 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023101 1 probable transmembrane helix predicted for EC042_4549 by TMHMM2.0 at aa 12-34 216592023102 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592023103 ImpA domain protein; Region: DUF3702; pfam12486 216592023104 HMMPfam hit to PF06812, ImpA-related N-terminal, score 6.2e-19 216592023105 4 probable transmembrane helices predicted for EC042_4551 by TMHMM2.0 at aa 5-27, 53-75, 95-117 and 121-140 216592023106 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 216592023107 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592023108 Active Sites [active] 216592023109 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 216592023110 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216592023111 ParB-like nuclease domain; Region: ParBc; pfam02195 216592023112 HMMPfam hit to PF02195, ParB-like nuclease domain, score 2.2e-08 216592023113 PerC transcriptional activator; Region: PerC; pfam06069 216592023114 HMMPfam hit to PF06069, PerC transcriptional activator, score 2.2e-57 216592023116 Note this CDS carries two frameshifts and lacks any obvious N-terminus, based on similarity searches. 216592023117 Note this CDS appears to have undergone multiple deletions including a large region connecting the two sequence remnants that remain 216592023118 Similar to Shigella sonnei insertion element is630 hypothetical 39 kDa protein SWALL:YIS5_SHISO (SWALL:P16943) (343 aa) fasta scores: E(): 3.3e-122, 83.09% id in 343 aa, and to Escherichia coli tnpa-like protein SWALL:AAP70294 (EMBL:AY233333) (343 aa) fasta scores: E(): 3e-126, 84.54% id in 343 aa, and to Photorhabdus luminescens transposase, is630 family isplu10k or plu0385 or isplu10g or plu1898 or isplu10f or plu2414 SWALL:Q7M775 (EMBL:BX571860) (337 aa) fasta scores: E(): 2.3e-74, 55.25% id in 333 aa; Note this CDS carries multiple frameshift mutations. 216592023119 Type VI secretion system 3 216592023120 Protein of unknown function (DUF770); Region: DUF770; pfam05591 216592023121 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 4e-54 216592023122 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 216592023123 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216592023124 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 2.9e-272 216592023125 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 216592023126 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 216592023127 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 216592023128 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 6.4e-84 216592023129 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 216592023130 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 3.9e-22 216592023131 1 probable transmembrane helix predicted for EC042_4568 by TMHMM2.0 at aa 149-171 216592023132 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216592023133 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216592023134 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 216592023135 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 1.3e-31 216592023136 PAAR motif; Region: PAAR_motif; cl15808 216592023137 HMMPfam hit to PF05488, PAAR motif, score 16 216592023138 HMMPfam hit to PF05488, PAAR motif, score 0.063 216592023139 HMMPfam hit to PF05488, PAAR motif, score 0.0014 216592023140 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 216592023141 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592023142 HMMPfam hit to PF06812, ImpA-related N-terminal, score 2.4e-21 216592023143 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 216592023144 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023145 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 216592023146 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 216592023147 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 4.6e-12 216592023148 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 216592023149 1 probable transmembrane helix predicted for EC042_4575 by TMHMM2.0 at aa 177-199 216592023150 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 216592023151 2 probable transmembrane helices predicted for EC042_4576 by TMHMM2.0 at aa 5-27 and 39-61 216592023152 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 216592023153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023154 Walker A motif; other site 216592023155 ATP binding site [chemical binding]; other site 216592023156 Walker B motif; other site 216592023157 arginine finger; other site 216592023158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023159 Walker A motif; other site 216592023160 ATP binding site [chemical binding]; other site 216592023161 Walker B motif; other site 216592023162 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216592023163 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 4.9e-07 216592023164 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023165 PS00870 Chaperonins clpA/B signature 1. 216592023166 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.2e-75 216592023167 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023168 Note this CDS carries a frameshift mutation. 216592023169 Note this CDS carries a frameshift mutation and a premature stop codon. 216592023171 Protein of unknown function (DUF770); Region: DUF770; cl01402 216592023172 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216592023173 ImpA domain protein; Region: DUF3702; pfam12486 216592023174 1 probable transmembrane helix predicted for EC042_4582 by TMHMM2.0 at aa 180-202 216592023175 Similar to Escherichia coli hypothetical protein SWALL:Q8VR74 (EMBL:AF447814) (153 aa) fasta scores: E(): 1e-11, 85.71% id in 35 aa; Note this CDS appears to have been disrupted by the insertion of an IS element. 216592023176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216592023177 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216592023178 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216592023179 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 5.4e-33 216592023180 Similar to Escherichia coli putative transposase insk for insertion sequence element is150 insk or b3558 SWALL:INSK_ECOLI (SWALL:P19769) (283 aa) fasta scores: E(): 4.8e-26, 60.16% id in 118 aa, and to Shigella flexneri is103 orf s1482 SWALL:Q7UCM4 (EMBL:AE016982) (283 aa) fasta scores: E(): 1.3e-26, 61.01% id in 118 aa; Note this CDS appears to have been disrupted by the insertion of another IS element. 216592023181 Note this CDS appears to have been disrupted by the insertion of an IS element. 216592023182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216592023183 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216592023184 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216592023185 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2.7e-32 216592023186 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216592023187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592023188 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216592023189 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216592023190 HMMPfam hit to PF03050, Transposase IS66 family, score 9.1e-108 216592023191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592023192 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216592023193 HMMPfam hit to PF05717, IS66 Orf2 like protein, score 7.5e-64 216592023194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592023195 Transposase; Region: HTH_Tnp_1; pfam01527 216592023196 HMMPfam hit to PF01527, Transposase, score 2e-06 216592023197 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216592023198 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216592023199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 216592023200 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 216592023201 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 216592023202 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592023203 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592023204 HMMPfam hit to PF03797, Autotransporter beta-domain, score 4.6e-45 216592023205 HMMPfam hit to PF02395, Immunoglobulin A1 protease, score 0 216592023206 1 probable transmembrane helix predicted for EC042_4593 by TMHMM2.0 at aa 34-53 216592023207 Note this CDS is disrupted by the insertion of IS element 216592023208 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216592023209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216592023210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216592023211 HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family, score 2.4e-09 216592023212 Note this CDS is disrupted by the insertion of IS element 216592023213 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216592023214 Helix-turn-helix domain; Region: HTH_38; pfam13936 216592023215 Integrase core domain; Region: rve; pfam00665 216592023216 Predicted helix-turn-helix motif with score 1859.000, SD 5.52 at aa 21-96, sequence TGFSEIANILGSKPGTIFTMLRDTGGIKPHERKRAVAHLTLSEREEIRAGLSAKMSI RAIATALNRSPSTISREVQ 216592023217 Predicted helix-turn-helix motif with score 1036.000, SD 2.72 at aa 21-42, sequence TGFSEIANILGSKPGTIFTMLR 216592023218 Predicted helix-turn-helix motif with score 1859.000, SD 5.52 at aa 75-96, sequence MSIRAIATALNRSPSTISREVQ 216592023219 HMMPfam hit to PF00665, Integrase core domain, score 2.8e-33 216592023220 PS01043 Transposases, IS30 family, signature. 216592023221 1 probable transmembrane helix predicted for EC042_4598 by TMHMM2.0 at aa 74-96 216592023222 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 216592023223 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 216592023224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 216592023225 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.6e-16 216592023226 Note the frameshift mutation, following codon 246, which is situated within a homopolymeric tract 6xA. 216592023227 HMMPfam hit to PF01555, DNA methylase, score 1.6e-05 216592023228 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 216592023229 active site 216592023230 catalytic triad [active] 216592023231 HMMPfam hit to PF00082, Subtilase family, score 2.6e-07 216592023232 PS00136 Serine proteases, subtilase family, aspartic acid active site. 216592023233 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216592023234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023235 Walker A motif; other site 216592023236 ATP binding site [chemical binding]; other site 216592023237 Walker B motif; other site 216592023238 arginine finger; other site 216592023239 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 4.3e-48 216592023240 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023241 Note the frameshift mutation following codon 77. 216592023242 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.7e-20 216592023243 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 5.1e-08 216592023244 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 216592023246 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 216592023247 HMMPfam hit to PF03400, IS1 transposase, score 5.9e-113 216592023248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592023249 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592023250 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592023251 HMMPfam hit to PF03811, Insertion element protein, score 9.5e-70 216592023252 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592023253 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023254 integrase; Provisional; Region: PRK09692 216592023255 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592023256 active site 216592023257 Int/Topo IB signature motif; other site 216592023258 PS00018 EF-hand calcium-binding domain. 216592023259 HMMPfam hit to PF00589, Phage integrase family, score 1.9e-33 216592023260 putative transcriptional regulator; Provisional; Region: PRK11640 216592023261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592023262 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 216592023263 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 216592023264 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 216592023265 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 216592023266 DsbD alpha interface [polypeptide binding]; other site 216592023267 catalytic residues [active] 216592023268 HMMPfam hit to PF00085, Thioredoxin, score 2.8e-06 216592023269 PS00194 Thioredoxin family active site. 216592023270 8 probable transmembrane helices predicted for EC042_4612 by TMHMM2.0 at aa 5-22, 165-187, 207-229, 242-264, 294-316, 323-345, 360-377 and 384-406 216592023271 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmemb, score 1.1e-07 216592023272 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 216592023273 HMMPfam hit to PF03091, CutA1 divalent ion tolerance protein, score 4.4e-37 216592023274 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 216592023275 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 216592023276 11 probable transmembrane helices predicted for EC042_4614 by TMHMM2.0 at aa 15-37, 50-72, 87-109, 130-152, 162-184, 226-243, 258-277, 284-306, 326-345, 358-380 and 410-432 216592023277 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 1.2e-244 216592023278 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 216592023279 Aspartase; Region: Aspartase; cd01357 216592023280 active sites [active] 216592023281 tetramer interface [polypeptide binding]; other site 216592023282 HMMPfam hit to PF00206, Lyase, score 4.3e-180 216592023283 PS00163 Fumarate lyases signature. 216592023284 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 216592023285 3 probable transmembrane helices predicted for EC042_4616 by TMHMM2.0 at aa 4-21, 26-48 and 79-101 216592023286 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 1.6e-63 216592023287 putative transporter; Provisional; Region: PRK11021 216592023288 HMMPfam hit to PF00324, Amino acid permease, score 0.00016 216592023289 11 probable transmembrane helices predicted for EC042_4617 by TMHMM2.0 at aa 34-56, 61-83, 107-129, 134-156, 163-185, 205-227, 240-262, 285-307, 336-358, 363-385 and 392-426 216592023290 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216592023291 oligomerisation interface [polypeptide binding]; other site 216592023292 mobile loop; other site 216592023293 roof hairpin; other site 216592023294 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit, score 3.1e-51 216592023295 PS00681 Chaperonins cpn10 signature. 216592023296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216592023297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216592023298 ring oligomerisation interface [polypeptide binding]; other site 216592023299 ATP/Mg binding site [chemical binding]; other site 216592023300 stacking interactions; other site 216592023301 hinge regions; other site 216592023302 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 1.1e-192 216592023303 PS00296 Chaperonins cpn60 signature. 216592023304 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 216592023305 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023306 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 216592023307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592023308 FeS/SAM binding site; other site 216592023309 HMMPfam hit to PF04055, Radical SAM superfamily, score 5e-09 216592023310 elongation factor P; Validated; Region: PRK00529 216592023311 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216592023312 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 216592023313 RNA binding site [nucleotide binding]; other site 216592023314 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 216592023315 RNA binding site [nucleotide binding]; other site 216592023316 HMMPfam hit to PF01132, Elongation factor P (EF-P), score 1.3e-124 216592023317 PS01275 Elongation factor P signature. 216592023318 multidrug efflux system protein; Provisional; Region: PRK11431 216592023319 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 2.3e-49 216592023320 4 probable transmembrane helices predicted for EC042_4624 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104 216592023321 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 216592023322 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 216592023323 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592023324 PS00213 Lipocalin signature. 216592023325 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023326 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 216592023327 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216592023328 HMMPfam hit to PF00144, Beta-lactamase, score 2.5e-110 216592023329 PS00336 Beta-lactamase class-C active site. 216592023330 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023331 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 216592023332 Iron-sulfur protein interface; other site 216592023333 proximal quinone binding site [chemical binding]; other site 216592023334 C-subunit interface; other site 216592023335 distal quinone binding site; other site 216592023336 HMMPfam hit to PF02313, Fumarate reductase subunit D, score 9.7e-88 216592023337 3 probable transmembrane helices predicted for EC042_4627 by TMHMM2.0 at aa 13-46, 56-78 and 99-118 216592023338 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 216592023339 D-subunit interface [polypeptide binding]; other site 216592023340 Iron-sulfur protein interface; other site 216592023341 proximal quinone binding site [chemical binding]; other site 216592023342 distal quinone binding site [chemical binding]; other site 216592023343 HMMPfam hit to PF02300, Fumarate reductase subunit C, score 1.7e-103 216592023344 3 probable transmembrane helices predicted for EC042_4628 by TMHMM2.0 at aa 27-49, 69-91 and 112-130 216592023345 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 216592023346 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216592023347 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00075 216592023348 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592023349 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.011 216592023350 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216592023351 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 216592023352 L-aspartate oxidase; Provisional; Region: PRK06175 216592023353 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216592023354 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 2e-67 216592023355 HMMPfam hit to PF00890, FAD binding domain, score 5.1e-207 216592023356 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 216592023357 poxB regulator PoxA; Provisional; Region: PRK09350 216592023358 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216592023359 motif 1; other site 216592023360 dimer interface [polypeptide binding]; other site 216592023361 active site 216592023362 motif 2; other site 216592023363 motif 3; other site 216592023364 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3e-158 216592023365 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216592023366 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592023367 inner membrane transporter YjeM; Provisional; Region: PRK15238 216592023368 HMMPfam hit to PF00324, Amino acid permease, score 8.2e-05 216592023369 12 probable transmembrane helices predicted for EC042_4632 by TMHMM2.0 at aa 24-46, 50-72, 93-115, 142-164, 176-198, 222-244, 257-279, 324-346, 375-397, 407-429, 449-471 and 481-498 216592023370 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 216592023371 3 probable transmembrane helices predicted for EC042_4633 by TMHMM2.0 at aa 7-26, 55-72 and 79-98 216592023372 putative mechanosensitive channel protein; Provisional; Region: PRK10929 216592023373 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 216592023374 DNA-binding site [nucleotide binding]; DNA binding site 216592023375 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 216592023376 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216592023377 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 1.4e-77 216592023378 PS01246 Uncharacterized protein family UPF0003 signature. 216592023379 11 probable transmembrane helices predicted for EC042_4634 by TMHMM2.0 at aa 476-495, 516-538, 553-575, 596-617, 627-649, 670-692, 696-718, 784-806, 826-848, 879-898 and 908-930 216592023380 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 216592023381 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 3.1e-120 216592023382 GTPase RsgA; Reviewed; Region: PRK12288 216592023383 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216592023384 RNA binding site [nucleotide binding]; other site 216592023385 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 216592023386 GTPase/Zn-binding domain interface [polypeptide binding]; other site 216592023387 GTP/Mg2+ binding site [chemical binding]; other site 216592023388 G4 box; other site 216592023389 G5 box; other site 216592023390 G1 box; other site 216592023391 Switch I region; other site 216592023392 G2 box; other site 216592023393 G3 box; other site 216592023394 Switch II region; other site 216592023395 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 5.5e-149 216592023396 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023397 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 216592023398 catalytic site [active] 216592023399 putative active site [active] 216592023400 putative substrate binding site [chemical binding]; other site 216592023401 dimer interface [polypeptide binding]; other site 216592023402 HMMPfam hit to PF00929, Exonuclease, score 7e-38 216592023403 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 216592023404 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 216592023405 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00029 216592023406 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592023407 putative carbohydrate kinase; Provisional; Region: PRK10565 216592023408 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 216592023409 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 216592023410 putative substrate binding site [chemical binding]; other site 216592023411 putative ATP binding site [chemical binding]; other site 216592023412 HMMPfam hit to PF03853, YjeF-related protein N-terminus, score 7.5e-78 216592023413 HMMPfam hit to PF01256, Carbohydrate kinase, score 2.3e-124 216592023414 PS00147 Arginase family signature 1. 216592023415 PS01049 Uncharacterized protein family UPF0031 signature 1. 216592023416 PS01050 Uncharacterized protein family UPF0031 signature 2. 216592023417 ADP-binding protein; Provisional; Region: PRK10646 216592023418 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 7.4e-70 216592023419 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023420 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 216592023421 AMIN domain; Region: AMIN; pfam11741 216592023422 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216592023423 active site 216592023424 metal binding site [ion binding]; metal-binding site 216592023425 1 probable transmembrane helix predicted for EC042_4642 by TMHMM2.0 at aa 13-35 216592023426 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 4.5e-78 216592023427 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 216592023428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592023429 ATP binding site [chemical binding]; other site 216592023430 Mg2+ binding site [ion binding]; other site 216592023431 G-X-G motif; other site 216592023432 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 216592023433 ATP binding site [chemical binding]; other site 216592023434 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 216592023435 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 1.5e-07 216592023436 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 216592023437 HMMPfam hit to PF01119, DNA mismatch repair protein, C-termina, score 7.2e-48 216592023438 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 216592023439 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 216592023440 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023441 HMMPfam hit to PF01715, IPP transferase, score 4.6e-164 216592023442 bacterial Hfq-like; Region: Hfq; cd01716 216592023443 hexamer interface [polypeptide binding]; other site 216592023444 Sm1 motif; other site 216592023445 RNA binding site [nucleotide binding]; other site 216592023446 Sm2 motif; other site 216592023447 HMMPfam hit to PF01423, LSM domain, score 1.2e-11 216592023448 GTPase HflX; Provisional; Region: PRK11058 216592023449 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 216592023450 HflX GTPase family; Region: HflX; cd01878 216592023451 G1 box; other site 216592023452 GTP/Mg2+ binding site [chemical binding]; other site 216592023453 Switch I region; other site 216592023454 G2 box; other site 216592023455 G3 box; other site 216592023456 Switch II region; other site 216592023457 G4 box; other site 216592023458 G5 box; other site 216592023459 HMMPfam hit to PF01926, GTPase of unknown function, score 1.3e-40 216592023460 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023461 FtsH protease regulator HflK; Provisional; Region: PRK10930 216592023462 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 216592023463 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 216592023464 1 probable transmembrane helix predicted for EC042_4647 by TMHMM2.0 at aa 76-98 216592023465 HMMPfam hit to PF01145, SPFH domain / Band, score 1.7e-52 216592023466 FtsH protease regulator HflC; Provisional; Region: PRK11029 216592023467 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 216592023468 1 probable transmembrane helix predicted for EC042_4648 by TMHMM2.0 at aa 5-23 216592023469 HMMPfam hit to PF01145, SPFH domain / Band, score 3.9e-59 216592023470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 216592023471 2 probable transmembrane helices predicted for EC042_4649 by TMHMM2.0 at aa 5-27 and 42-60 216592023472 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 216592023473 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 216592023474 GDP-binding site [chemical binding]; other site 216592023475 ACT binding site; other site 216592023476 IMP binding site; other site 216592023477 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 216592023478 PS01266 Adenylosuccinate synthetase GTP-binding site. 216592023479 PS00513 Adenylosuccinate synthetase active site. 216592023480 Predicted transcriptional regulator [Transcription]; Region: COG1959 216592023481 transcriptional repressor NsrR; Provisional; Region: PRK11014 216592023482 HMMPfam hit to PF02082, Transcriptional regulator, score 1.3e-45 216592023483 Predicted helix-turn-helix motif with score 1165.000, SD 3.15 at aa 26-47, sequence TSISEVTDVYGVSRNHMVKIIN 216592023484 PS01332 Uncharacterized protein family UPF0074 signature. 216592023485 exoribonuclease R; Provisional; Region: PRK11642 216592023486 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 216592023487 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 216592023488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216592023489 RNB domain; Region: RNB; pfam00773 216592023490 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 216592023491 RNA binding site [nucleotide binding]; other site 216592023492 HMMPfam hit to PF00773, RNB-like protein, score 9.7e-143 216592023493 PS01175 Ribonuclease II family signature. 216592023494 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.2e-23 216592023495 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023496 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 216592023497 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 216592023498 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216592023499 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 2.3e-67 216592023500 Unique to 042, islet, misc. utilization (regulator, transporter, enzymes) 216592023501 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216592023502 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216592023503 Bacterial transcriptional regulator; Region: IclR; pfam01614 216592023504 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 2.2e-23 216592023505 Predicted helix-turn-helix motif with score 1123.000, SD 3.01 at aa 23-44, sequence VSLTHLSEKTGILKGTIFPILK 216592023506 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216592023507 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216592023508 inhibitor site; inhibition site 216592023509 active site 216592023510 dimer interface [polypeptide binding]; other site 216592023511 catalytic residue [active] 216592023512 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 9.6e-43 216592023513 PS00666 Dihydrodipicolinate synthetase signature 2. 216592023514 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216592023515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592023516 putative substrate translocation pore; other site 216592023517 12 probable transmembrane helices predicted for EC042_4656 by TMHMM2.0 at aa 23-40, 60-82, 89-108, 113-135, 148-170, 180-202, 246-268, 283-301, 313-332, 337-359, 368-390 and 400-422 216592023518 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-46 216592023519 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 216592023520 galactarate dehydratase; Region: galactar-dH20; TIGR03248 216592023521 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 216592023522 HMMPfam hit to PF04292, D-galactarate dehydratase / Altronate hydrol, score 3.1e-12 216592023523 HMMPfam hit to PF04295, D-galactarate dehydratase / Altronate hydrol, score 3.4e-91 216592023524 PS00024 Hemopexin domain signature. 216592023527 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 216592023528 Predicted membrane protein [Function unknown]; Region: COG3766 216592023529 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 216592023530 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 216592023531 HMMPfam hit to PF03994, Domain of Unknown Function (DUF350), score 6.8e-23 216592023532 4 probable transmembrane helices predicted for EC042_4663 by TMHMM2.0 at aa 6-28, 48-70, 75-97 and 104-126 216592023533 HMMPfam hit to PF03994, Domain of Unknown Function (DUF350), score 1.4e-19 216592023535 HMMPfam hit to PF06693, Protein of unknown function (DUF1190), score 3.7e-62 216592023536 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 216592023537 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 2.7e-268 216592023538 PS00107 Protein kinases ATP-binding region signature. 216592023539 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 216592023540 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 216592023541 FAD binding site [chemical binding]; other site 216592023542 substrate binding site [chemical binding]; other site 216592023543 catalytic residues [active] 216592023544 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal doma, score 4.1e-55 216592023545 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase, middle domain, score 3.3e-48 216592023546 PS00072 Acyl-CoA dehydrogenases signature 1. 216592023547 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 6.2e-49 216592023548 PS00073 Acyl-CoA dehydrogenases signature 2. 216592023549 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592023550 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.9e-49 216592023551 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 216592023552 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 2.2e-05 216592023553 1 probable transmembrane helix predicted for EC042_4669 by TMHMM2.0 at aa 9-31 216592023554 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592023555 esterase; Provisional; Region: PRK10566 216592023556 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216592023557 transcriptional repressor UlaR; Provisional; Region: PRK13509 216592023558 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216592023559 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592023560 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.5e-108 216592023561 Predicted helix-turn-helix motif with score 1406.000, SD 3.98 at aa 20-41, sequence VTVEKVVERLGISPATARRDIN 216592023562 PS00894 Bacterial regulatory proteins, deoR family signature. 216592023564 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 216592023565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 216592023566 HMMPfam hit to PF04215, Putative sugar-specific permease, SgaT/UlaA, score 4.8e-278 216592023567 10 probable transmembrane helices predicted for EC042_4674 by TMHMM2.0 at aa 30-52, 59-81, 118-140, 160-191, 252-271, 283-305, 325-347, 359-381, 396-418 and 443-465 216592023568 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216592023569 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 216592023570 active site 216592023571 P-loop; other site 216592023572 phosphorylation site [posttranslational modification] 216592023573 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 1.1e-33 216592023574 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592023575 active site 216592023576 phosphorylation site [posttranslational modification] 216592023577 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 2.6e-74 216592023578 PS00372 PTS EIIA domains phosphorylation site signature 2. 216592023579 PS00387 Inorganic pyrophosphatase signature. 216592023581 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 4.6e-15 216592023583 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 7e-44 216592023584 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 216592023585 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 216592023586 intersubunit interface [polypeptide binding]; other site 216592023587 active site 216592023588 Zn2+ binding site [ion binding]; other site 216592023589 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 1.7e-100 216592023590 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 216592023591 HMMPfam hit to PF07338, Protein of unknown function (DUF1471), score 1.1e-48 216592023592 1 probable transmembrane helix predicted for EC042_4681 by TMHMM2.0 at aa 23-45 216592023593 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 216592023594 HMMPfam hit to PF01250, Ribosomal protein S6, score 5.4e-51 216592023595 PS01048 Ribosomal protein S6 signature. 216592023596 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592023597 dimer interface [polypeptide binding]; other site 216592023598 ssDNA binding site [nucleotide binding]; other site 216592023599 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592023600 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 216592023601 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.2e-32 216592023602 PS00057 Ribosomal protein S18 signature. 216592023603 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 216592023604 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 216592023605 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 216592023606 HMMPfam hit to PF01281, Ribosomal protein L9, N-terminal domai, score 4e-30 216592023607 PS00651 Ribosomal protein L9 signature. 216592023608 HMMPfam hit to PF03948, Ribosomal protein L9, C-terminal domai, score 3e-44 216592023609 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 216592023610 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 216592023611 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 216592023612 HMMPfam hit to PF04225, Opacity-associated protein A, score 4.1e-08 216592023613 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 216592023614 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 216592023615 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216592023616 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 8.3e-08 216592023617 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 2.9e-47 216592023618 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216592023619 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216592023620 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 216592023621 HMMPfam hit to PF00324, Amino acid permease, score 2e-173 216592023622 12 probable transmembrane helices predicted for EC042_4689 by TMHMM2.0 at aa 27-44, 49-71, 104-126, 136-158, 165-187, 210-232, 252-274, 289-311, 342-364, 374-396, 417-435 and 439-461 216592023623 PS00218 Amino acid permeases signature. 216592023624 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 216592023625 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 216592023626 Hemerythrin-like domain; Region: Hr-like; cd12108 216592023627 Fe binding site [ion binding]; other site 216592023628 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 4.8e-08 216592023629 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 3.5e-06 216592023630 HMMPfam hit to PF04405, Domain of Unknown function (DUF542), score 3.7e-43 216592023631 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216592023632 EamA-like transporter family; Region: EamA; pfam00892 216592023633 10 probable transmembrane helices predicted for EC042_4691 by TMHMM2.0 at aa 7-29, 33-55, 67-89, 94-116, 123-145, 155-177, 198-220, 235-257, 264-286 and 290-309 216592023634 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.3e-08 216592023635 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216592023636 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 216592023637 NADP binding site [chemical binding]; other site 216592023638 Predicted transcriptional regulators [Transcription]; Region: COG1733 216592023639 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216592023640 HMMPfam hit to PF01638, Transcriptional regulator, score 1.1e-48 216592023641 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 216592023642 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 216592023643 active site 216592023644 metal binding site [ion binding]; metal-binding site 216592023645 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216592023646 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.5e-63 216592023647 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 4e-19 216592023648 PS00786 5'-nucleotidase signature 2. 216592023649 PS00785 5'-nucleotidase signature 1. 216592023650 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216592023651 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216592023652 active site 216592023653 HMMPfam hit to PF00459, Inositol monophosphatase family, score 2.6e-79 216592023654 PS00629 Inositol monophosphatase family signature 1. 216592023655 PS00630 Inositol monophosphatase family signature 2. 216592023656 1 probable transmembrane helix predicted for EC042_4696 by TMHMM2.0 at aa 25-47 216592023658 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 216592023659 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 216592023660 HMMPfam hit to PF06526, Protein of unknown function (DUF1107), score 2e-46 216592023661 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216592023662 Domain of unknown function DUF21; Region: DUF21; pfam01595 216592023663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216592023664 Transporter associated domain; Region: CorC_HlyC; smart01091 216592023665 HMMPfam hit to PF03471, Transporter associated domain, score 4.2e-23 216592023666 HMMPfam hit to PF00571, CBS domain, score 1.1e-05 216592023667 HMMPfam hit to PF00571, CBS domain, score 6.3e-07 216592023668 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 6.7e-73 216592023669 4 probable transmembrane helices predicted for EC042_4700 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 142-164 216592023670 methionine sulfoxide reductase A; Provisional; Region: PRK00058 216592023671 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 1.2e-111 216592023672 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 216592023673 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216592023674 Surface antigen; Region: Bac_surface_Ag; pfam01103 216592023675 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.4 216592023676 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3.2e-07 216592023677 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2.7 216592023678 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592023679 HMMPfam hit to PF01103, Surface antigen, score 7.3e-81 216592023680 PS00213 Lipocalin signature. 216592023681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 216592023682 Family of unknown function (DUF490); Region: DUF490; pfam04357 216592023683 1 probable transmembrane helix predicted for EC042_4703 by TMHMM2.0 at aa 7-29 216592023684 PS00213 Lipocalin signature. 216592023685 HMMPfam hit to PF04357, Family of unknown function (DUF490), score 1.9e-174 216592023686 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216592023687 putative active site pocket [active] 216592023688 dimerization interface [polypeptide binding]; other site 216592023689 putative catalytic residue [active] 216592023690 HMMPfam hit to PF03674, Uncharacterised protein family (UPF0131), score 2.2e-53 216592023691 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216592023692 dimer interface [polypeptide binding]; other site 216592023693 substrate binding site [chemical binding]; other site 216592023694 metal binding sites [ion binding]; metal-binding site 216592023695 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 6.6e-64 216592023696 PS00387 Inorganic pyrophosphatase signature. 216592023697 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 216592023698 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216592023699 putative ligand binding site [chemical binding]; other site 216592023700 1 probable transmembrane helix predicted for EC042_4706 by TMHMM2.0 at aa 5-27 216592023701 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 5.6e-05 216592023702 PS00063 Aldo/keto reductase family putative active site signature. 216592023704 HMMPfam hit to PF00005, ABC transporter, score 5.5e-61 216592023705 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023706 HMMPfam hit to PF00005, ABC transporter, score 1.7e-25 216592023707 PS00211 ABC transporters family signature. 216592023708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592023709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592023710 TM-ABC transporter signature motif; other site 216592023711 8 probable transmembrane helices predicted for EC042_4708 by TMHMM2.0 at aa 32-54, 74-96, 109-131, 180-202, 231-253, 263-282, 289-311 and 321-338 216592023712 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.4e-78 216592023713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216592023714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216592023715 TM-ABC transporter signature motif; other site 216592023716 8 probable transmembrane helices predicted for EC042_4709 by TMHMM2.0 at aa 10-32, 44-77, 87-109, 116-135, 158-180, 210-232, 247-269 and 290-312 216592023717 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 5.5e-53 216592023718 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 216592023719 AMP binding site [chemical binding]; other site 216592023720 metal binding site [ion binding]; metal-binding site 216592023721 active site 216592023722 HMMPfam hit to PF00316, Fructose-1-6-bisphosphatase, score 1.1e-220 216592023723 PS00124 Fructose-1-6-bisphosphatase active site. 216592023724 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 216592023725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216592023726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216592023727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216592023728 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 1.1e-60 216592023729 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 9.4e-23 216592023730 hypothetical protein; Provisional; Region: PRK05255 216592023731 HMMPfam hit to PF04751, Protein of unknown function (DUF615), score 1.9e-121 216592023732 peptidase PmbA; Provisional; Region: PRK11040 216592023733 HMMPfam hit to PF01523, Putative modulator of DNA gyrase, score 6.4e-106 216592023734 cytochrome b562; Provisional; Region: PRK15058 216592023735 HMMPfam hit to PF07361, Cytochrome b562, score 1.1e-60 216592023736 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 216592023737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592023738 FeS/SAM binding site; other site 216592023739 PS01087 Radical activating enzymes signature. 216592023740 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 216592023741 ATP cone domain; Region: ATP-cone; pfam03477 216592023742 Class III ribonucleotide reductase; Region: RNR_III; cd01675 216592023743 effector binding site; other site 216592023744 active site 216592023745 Zn binding site [ion binding]; other site 216592023746 glycine loop; other site 216592023747 HMMPfam hit to PF01228, Glycine radical, score 1e-56 216592023748 PS00850 Glycine radical signature. 216592023749 HMMPfam hit to PF03477, ATP cone domain, score 1.7e-30 216592023750 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 216592023751 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 216592023752 Ca binding site [ion binding]; other site 216592023753 active site 216592023754 catalytic site [active] 216592023755 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 216592023756 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 7e-152 216592023757 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 216592023758 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 216592023759 active site turn [active] 216592023760 phosphorylation site [posttranslational modification] 216592023761 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 216592023762 10 probable transmembrane helices predicted for EC042_4718 by TMHMM2.0 at aa 107-129, 155-177, 184-206, 226-245, 257-279, 299-321, 342-361, 371-393, 406-428 and 438-460 216592023763 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.5e-30 216592023764 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 5.7e-09 216592023765 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216592023766 trehalose repressor; Provisional; Region: treR; PRK09492 216592023767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592023768 DNA binding site [nucleotide binding] 216592023769 domain linker motif; other site 216592023770 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 216592023771 dimerization interface [polypeptide binding]; other site 216592023772 ligand binding site [chemical binding]; other site 216592023773 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.0032 216592023774 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.1e-11 216592023775 Predicted helix-turn-helix motif with score 2311.000, SD 7.06 at aa 5-26, sequence LTIKDIARLSGVGKSTVSRVLN 216592023776 PS00356 Bacterial regulatory proteins, lacI family signature. 216592023777 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 216592023778 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 216592023779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216592023780 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 216592023781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592023782 motif II; other site 216592023783 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216592023784 HMMPfam hit to PF00690, Cation transporter/ATPase, N-terminus, score 1.3e-16 216592023785 7 probable transmembrane helices predicted for EC042_4720 by TMHMM2.0 at aa 123-142, 296-315, 325-347, 715-737, 774-796, 837-859 and 874-896 216592023786 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.1e-92 216592023787 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.6e-15 216592023788 PS00154 E1-E2 ATPases phosphorylation site. 216592023789 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216592023790 homotrimer interaction site [polypeptide binding]; other site 216592023791 putative active site [active] 216592023792 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 4.5e-65 216592023793 PS01094 Uncharacterized protein family UPF0076 signature. 216592023794 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 216592023795 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 216592023796 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 216592023797 HMMPfam hit to PF02748, Aspartate carbamoyltransferase regulatory ch, score 7.7e-30 216592023798 HMMPfam hit to PF01948, Aspartate carbamoyltransferase regulatory ch, score 2.1e-63 216592023799 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 216592023800 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216592023801 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216592023802 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 5.6e-71 216592023803 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 1.1e-77 216592023804 PS00097 Aspartate and ornithine carbamoyltransferases signature. 216592023805 Present in 0157, divergent in Uropathogenic, misc. metabolism (regulator, hypothetical proteins, oxidoreductase) 216592023806 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 216592023807 homotrimer interaction site [polypeptide binding]; other site 216592023808 putative active site [active] 216592023809 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 3e-47 216592023810 oxidoreductase; Provisional; Region: PRK12742 216592023811 classical (c) SDRs; Region: SDR_c; cd05233 216592023812 NAD(P) binding site [chemical binding]; other site 216592023813 active site 216592023814 HMMPfam hit to PF00106, short chain dehydrogenase, score 9.8e-81 216592023815 PS00061 Short-chain dehydrogenases/reductases family signature. 216592023816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216592023817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216592023818 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.2e-12 216592023819 Predicted helix-turn-helix motif with score 1204.000, SD 3.29 at aa 37-58, sequence VSVAEVTDYLGINPPSLYAAFG 216592023820 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 216592023821 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 1.1e-78 216592023823 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 216592023824 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216592023825 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216592023826 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 7.8e-102 216592023827 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 6.2e-87 216592023828 PS00097 Aspartate and ornithine carbamoyltransferases signature. 216592023829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 216592023830 RNase E inhibitor protein; Provisional; Region: PRK11191 216592023831 HMMPfam hit to PF06877, Protein of unknown function (DUF1260), score 5.9e-84 216592023832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216592023833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592023834 Coenzyme A binding pocket [chemical binding]; other site 216592023835 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.6e-21 216592023836 Predicted membrane protein [Function unknown]; Region: COG4269 216592023837 HMMPfam hit to PF05987, Bacterial protein of unknown function (DUF89, score 8.7e-229 216592023838 8 probable transmembrane helices predicted for EC042_4732 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 150-172, 185-216, 236-258, 288-310 and 341-363 216592023839 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 216592023840 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216592023841 HIGH motif; other site 216592023842 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216592023843 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216592023844 active site 216592023845 KMSKS motif; other site 216592023846 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 216592023847 tRNA binding surface [nucleotide binding]; other site 216592023848 anticodon binding site; other site 216592023849 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 216592023850 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 216592023851 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216592023852 DNA polymerase III subunit chi; Validated; Region: PRK05728 216592023853 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 4e-82 216592023854 multifunctional aminopeptidase A; Provisional; Region: PRK00913 216592023855 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 216592023856 interface (dimer of trimers) [polypeptide binding]; other site 216592023857 Substrate-binding/catalytic site; other site 216592023858 Zn-binding sites [ion binding]; other site 216592023859 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 9.8e-211 216592023860 PS00631 Cytosol aminopeptidase signature. 216592023861 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 3.8e-53 216592023862 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 216592023863 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216592023864 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 6.8e-76 216592023865 6 probable transmembrane helices predicted for EC042_4736 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289, 296-314 and 329-348 216592023866 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 216592023867 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216592023868 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 8.2e-93 216592023869 6 probable transmembrane helices predicted for EC042_4737 by TMHMM2.0 at aa 12-34, 65-84, 105-127, 280-299, 306-328 and 338-357 216592023870 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 216592023871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216592023872 Walker A motif; other site 216592023873 ATP binding site [chemical binding]; other site 216592023874 HMMPfam hit to PF05872, Bacterial protein of unknown function (DUF85, score 0 216592023875 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023876 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216592023877 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216592023878 putative NAD(P) binding site [chemical binding]; other site 216592023879 putative substrate binding site [chemical binding]; other site 216592023880 catalytic Zn binding site [ion binding]; other site 216592023881 structural Zn binding site [ion binding]; other site 216592023882 dimer interface [polypeptide binding]; other site 216592023883 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 7.1e-89 216592023884 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216592023885 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592023886 PS00190 Cytochrome c family heme-binding site signature. 216592023887 Divergent in 0157 and Uropathogenic, pathogenicity island, similarity to plasmid bourne proteins, (signal transduction protein, LacI regulator, PTS transporter, Major Facilitator Superfamily protein, DeoR regulator, putative choline transporter, LPS biosynthesis protein, VirK-required for proper localization of icsa (virg) at the surface of Shigella, glycosyl transferase, Fec iron(iii) dicitrate transport transport system, including fecR and fecI, aemolysin expression modulating protein, pertactin-domain autotransporter protein, ntirestriction protein, helicase, putative restriction system proteins), posible composite with insertion of island witin unique region, island inserted at a tRNA and is flanked by repeats 216592023888 Genomic island 4. misc island region within 042_ROD72 216592023889 integrase; Provisional; Region: PRK09692 216592023890 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216592023891 active site 216592023892 Int/Topo IB signature motif; other site 216592023893 HMMPfam hit to PF00589, Phage integrase family, score 2.1e-42 216592023894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216592023895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216592023896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592023897 ATP binding site [chemical binding]; other site 216592023898 Mg2+ binding site [ion binding]; other site 216592023899 G-X-G motif; other site 216592023900 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 8.4e-19 216592023901 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216592023902 PS00190 Cytochrome c family heme-binding site signature. 216592023903 PS00215 Mitochondrial energy transfer proteins signature. 216592023904 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023905 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 216592023906 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216592023907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216592023908 DNA binding site [nucleotide binding] 216592023909 domain linker motif; other site 216592023910 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216592023911 putative dimerization interface [polypeptide binding]; other site 216592023912 putative ligand binding site [chemical binding]; other site 216592023913 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.6e-05 216592023914 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 3.8e-07 216592023915 Predicted helix-turn-helix motif with score 1795.000, SD 5.30 at aa 13-34, sequence VTLQEVANFAGVGTMTVSRALR 216592023916 PS00356 Bacterial regulatory proteins, lacI family signature. 216592023917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216592023918 active site 216592023919 phosphorylation site [posttranslational modification] 216592023920 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 4e-38 216592023921 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 216592023922 active site 216592023923 P-loop; other site 216592023924 phosphorylation site [posttranslational modification] 216592023925 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific IIB, score 7.3e-29 216592023926 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 216592023927 HMMPfam hit to PF04215, Putative sugar-specific permease, SgaT/UlaA, score 3.9e-130 216592023928 12 probable transmembrane helices predicted for EC042_4750 by TMHMM2.0 at aa 7-29, 44-63, 98-115, 119-141, 148-170, 180-202, 223-245, 255-274, 307-329, 339-361, 368-390 and 394-416 216592023929 Transposase; Region: HTH_Tnp_1; pfam01527 216592023930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592023931 HMMPfam hit to PF01527, Transposase, score 1.4e-14 216592023932 putative transposase OrfB; Reviewed; Region: PHA02517 216592023933 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 216592023934 active site 216592023935 catalytic residues [active] 216592023936 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216592023937 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 216592023938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592023939 putative substrate translocation pore; other site 216592023940 12 probable transmembrane helices predicted for EC042_4754 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 109-128, 149-171, 205-227, 256-278, 293-312, 319-336, 340-362, 375-397 and 401-423 216592023941 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.7e-23 216592023942 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216592023943 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 216592023944 substrate binding site [chemical binding]; other site 216592023945 dimer interface [polypeptide binding]; other site 216592023946 ATP binding site [chemical binding]; other site 216592023947 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 6.4e-68 216592023948 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 216592023949 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216592023950 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216592023951 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 1.6e-37 216592023952 PS00894 Bacterial regulatory proteins, deoR family signature. 216592023953 Predicted helix-turn-helix motif with score 1703.000, SD 4.99 at aa 23-44, sequence IHLKDAARMLEVSVMTIRRDLH 216592023954 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216592023955 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 216592023956 IS2 repressor TnpA; Reviewed; Region: PRK09413 216592023957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592023958 HMMPfam hit to PF01527, Transposase, score 2.7e-34 216592023959 CDS lacks appropriate translational stop site, due to the insertion of the downstream IS66 family element 216592023960 HMMPfam hit to PF00665, Integrase core domain, score 2.1e-35 216592023961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592023962 Transposase; Region: HTH_Tnp_1; pfam01527 216592023963 HMMPfam hit to PF01527, Transposase, score 5.5e-15 216592023964 Predicted helix-turn-helix motif with score 1020.000, SD 2.66 at aa 31-52, sequence ACVAQIARENGVNDNVIFKWLR 216592023965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592023966 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216592023967 HMMPfam hit to PF05717, IS66 Orf2 like protein, score 1.3e-63 216592023968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592023969 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216592023970 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216592023971 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216592023972 HMMPfam hit to PF03050, Transposase IS66 family, score 1.4e-107 216592023973 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216592023974 CDS is disrupted by the insertion of an IS100 element after codon 67. Similar to Burkholderia sp. 383 transcriptional TetR family regulator UniProt:Q39AZ4 (EMBL:CP000152) (212 aa) fasta scores: E()=1.4e-32, 43.902% id in 205 aa 216592023975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 216592023976 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216592023977 DNA-binding interface [nucleotide binding]; DNA binding site 216592023978 Integrase core domain; Region: rve; pfam00665 216592023979 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 1.2e-05 216592023980 Predicted helix-turn-helix motif with score 2147.000, SD 6.50 at aa 18-39, sequence MSSRAIARELGISRNTVKRYLQ 216592023981 HMMPfam hit to PF00665, Integrase core domain, score 4.2e-22 216592023982 transposase/IS protein; Provisional; Region: PRK09183 216592023983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592023984 Walker A motif; other site 216592023985 ATP binding site [chemical binding]; other site 216592023986 Walker B motif; other site 216592023987 HMMPfam hit to PF01695, IstB-like ATP binding protein, score 3.7e-108 216592023988 PS00017 ATP/GTP-binding site motif A (P-loop). 216592023989 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.2e-10 216592023990 HMMPfam hit to PF02178, AT hook motif, score 0.039 216592023991 Predicted membrane protein [Function unknown]; Region: COG4325 216592023992 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 216592023993 4 probable transmembrane helices predicted for EC042_4766 by TMHMM2.0 at aa 15-37, 57-79, 104-126 and 133-155 216592023994 BCCT family transporter; Region: BCCT; cl00569 216592023995 HMMPfam hit to PF02028, BCCT family transporter, score 5.6e-225 216592023996 12 probable transmembrane helices predicted for EC042_4767 by TMHMM2.0 at aa 20-39, 54-76, 97-119, 152-174, 194-216, 236-255, 267-289, 320-342, 355-374, 409-431, 455-477 and 481-500 216592023997 PS01303 BCCT family of transporters signature. 216592023998 similar to transposase 216592023999 HMMPfam hit to PF00665, Integrase core domain, score 2.6e-44 216592024000 CDS contains an internal deletion (18bp) that results in a frameshift after codon 84. Similar to Shigella flexneri protein TnpJ UniProt:Q9XCG9 (EMBL:AE005674) (100 aa) fasta scores: E()=1.2e-28, 93.000% id in 100 aa 216592024001 HMMPfam hit to PF01527, Transposase, score 3e-23 216592024002 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216592024003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216592024004 putative acyl-acceptor binding pocket; other site 216592024005 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 8e-129 216592024006 1 probable transmembrane helix predicted for EC042_4769 by TMHMM2.0 at aa 19-41 216592024007 Protein of unknown function (DUF535); Region: DUF535; pfam04393 216592024008 HMMPfam hit to PF04393, Protein of unknown function (DUF535), score 1.7e-148 216592024009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216592024010 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216592024011 HMMPfam hit to PF00534, Glycosyl transferases group, score 2e-17 216592024012 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 216592024013 putative active site [active] 216592024014 putative metal binding site [ion binding]; other site 216592024015 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 3.5e-43 216592024016 IS911 family element 216592024017 frameshifted following codon 2 216592024018 HMMPfam hit to PF01527, Transposase, score 1.9e-15 216592024019 Predicted helix-turn-helix motif with score 1244.000, SD 3.42 at aa 33-54, sequence YTVADAASAMDVGLSTMTRWVK 216592024021 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 216592024022 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 216592024023 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216592024024 Walker A/P-loop; other site 216592024025 ATP binding site [chemical binding]; other site 216592024026 Q-loop/lid; other site 216592024027 ABC transporter signature motif; other site 216592024028 Walker B; other site 216592024029 D-loop; other site 216592024030 H-loop/switch region; other site 216592024031 PS00294 Prenyl group binding site (CAAX box). 216592024032 HMMPfam hit to PF00005, ABC transporter, score 6.3e-67 216592024033 PS00211 ABC transporters family signature. 216592024034 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024035 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 216592024036 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592024037 ABC-ATPase subunit interface; other site 216592024038 dimer interface [polypeptide binding]; other site 216592024039 putative PBP binding regions; other site 216592024040 HMMPfam hit to PF01032, FecCD transport family, score 1.3e-140 216592024041 8 probable transmembrane helices predicted for EC042_4777 by TMHMM2.0 at aa 13-35, 60-82, 95-114, 118-140, 190-212, 236-258, 278-300 and 306-325 216592024042 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 216592024043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216592024044 dimer interface [polypeptide binding]; other site 216592024045 ABC-ATPase subunit interface; other site 216592024046 putative PBP binding regions; other site 216592024047 HMMPfam hit to PF01032, FecCD transport family, score 3.2e-135 216592024048 7 probable transmembrane helices predicted for EC042_4778 by TMHMM2.0 at aa 4-26, 57-79, 114-136, 145-167, 191-213, 234-256 and 299-321 216592024049 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 216592024050 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216592024051 siderophore binding site; other site 216592024052 HMMPfam hit to PF01497, Periplasmic binding protein, score 3.5e-77 216592024053 1 probable transmembrane helix predicted for EC042_4779 by TMHMM2.0 at aa 2-24 216592024054 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 216592024055 Secretin and TonB N terminus short domain; Region: STN; smart00965 216592024056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216592024057 N-terminal plug; other site 216592024058 ligand-binding site [chemical binding]; other site 216592024059 HMMPfam hit to PF00593, TonB dependent receptor, score 1.8e-26 216592024060 PS01156 TonB-dependent receptor proteins signature 2. 216592024061 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.1e-18 216592024062 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 2.1e-11 216592024063 PS00430 TonB-dependent receptor proteins signature 1. 216592024064 Predicted helix-turn-helix motif with score 1074.000, SD 2.84 at aa 27-48, sequence LSFSAFAAQVNIAPGSLDKALN 216592024065 fec operon regulator FecR; Reviewed; Region: PRK09774 216592024066 FecR protein; Region: FecR; pfam04773 216592024067 HMMPfam hit to PF04773, FecR protein, score 1.3e-46 216592024068 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 216592024069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216592024070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216592024071 DNA binding residues [nucleotide binding] 216592024072 Predicted helix-turn-helix motif with score 1972.000, SD 5.90 at aa 137-158, sequence LTYSEIAHKLGVSISSVKKYVA 216592024073 HMMPfam hit to PF04542, Sigma-70 region, score 9e-15 216592024074 PS01063 Sigma-70 factors ECF subfamily signature. 216592024075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592024076 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592024077 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592024078 HMMPfam hit to PF03811, Insertion element protein, score 7.6e-66 216592024079 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024080 Predicted helix-turn-helix motif with score 1178.000, SD 3.20 at aa 64-85, sequence VGCRASARIMGVGLNTVLRHLK 216592024082 HMMPfam hit to PF03400, IS1 transposase, score 1.7e-12 216592024083 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216592024084 HMMPfam hit to PF03400, IS1 transposase, score 8.6e-27 216592024086 no significant database matches 216592024087 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216592024088 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 216592024089 homodimer interface [polypeptide binding]; other site 216592024090 putative GKAP docking site [polypeptide binding]; other site 216592024091 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216592024092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592024093 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216592024094 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216592024095 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216592024096 HMMPfam hit to PF03050, Transposase IS66 family, score 6.3e-128 216592024097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592024098 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216592024099 HMMPfam hit to PF05717, IS66 Orf2 like protein, score 1.6e-67 216592024100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024101 Transposase; Region: HTH_Tnp_1; pfam01527 216592024102 HMMPfam hit to PF01527, Transposase, score 8.2e-23 216592024103 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 216592024104 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 216592024105 PS00190 Cytochrome c family heme-binding site signature. 216592024106 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 216592024107 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 216592024108 PS00881 Protein splicing signature. 216592024109 1 probable transmembrane helix predicted for EC042_4795 by TMHMM2.0 at aa 41-63 216592024110 Haemolysin expression modulating protein; Region: HHA; pfam05321 216592024111 HMMPfam hit to PF05321, Haemolysin expression modulating protein, score 1.3e-11 216592024112 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 216592024113 HMMPfam hit to PF05930, Prophage CP4-57 regulatory protein (AlpA), score 4.9e-22 216592024115 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 216592024116 Predicted GTPase [General function prediction only]; Region: COG3596 216592024117 YfjP GTPase; Region: YfjP; cd11383 216592024118 G1 box; other site 216592024119 GTP/Mg2+ binding site [chemical binding]; other site 216592024120 Switch I region; other site 216592024121 G2 box; other site 216592024122 Switch II region; other site 216592024123 G3 box; other site 216592024124 G4 box; other site 216592024125 G5 box; other site 216592024126 HMMPfam hit to PF01926, GTPase of unknown function, score 1.4e-19 216592024127 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024128 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592024129 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 216592024130 hypothetical protein; Provisional; Region: PRK09945 216592024131 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216592024132 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592024133 Autotransporter beta-domain; Region: Autotransporter; smart00869 216592024134 HMMPfam hit to PF05594, no description, score 6.6 216592024135 HMMPfam hit to PF05594, no description, score 4.4 216592024136 HMMPfam hit to PF03212, Pertactin, score 4.7e-05 216592024137 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024138 HMMPfam hit to PF03797, Autotransporter beta-domain, score 4.3e-30 216592024139 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 216592024140 HMMPfam hit to PF06006, Bacterial protein of unknown function (DUF90, score 3.2e-13 216592024141 Domain of unknown function (DUF932); Region: DUF932; pfam06067 216592024142 HMMPfam hit to PF06067, Domain of unknown function (DUF932), score 1e-220 216592024143 Antirestriction protein; Region: Antirestrict; pfam03230 216592024144 HMMPfam hit to PF03230, Antirestriction protein, score 7.3e-52 216592024145 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 216592024146 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216592024147 MPN+ (JAMM) motif; other site 216592024148 Zinc-binding site [ion binding]; other site 216592024149 HMMPfam hit to PF04002, RadC, DNA repair protein, score 1.6e-82 216592024150 PS01302 DNA repair protein radC family signature. 216592024151 Protein of unknown function (DUF987); Region: DUF987; pfam06174 216592024152 HMMPfam hit to PF06174, Protein of unknown function (DUF987), score 8.1e-56 216592024153 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 216592024154 HMMPfam hit to PF06154, YagB/YeeU/YfjZ family, score 5.2e-86 216592024155 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 216592024156 HMMPfam hit to PF06755, Protein of unknown function (DUF1219), score 2e-99 216592024158 IS2 transposase TnpB; Reviewed; Region: PRK09409 216592024159 HTH-like domain; Region: HTH_21; pfam13276 216592024160 Integrase core domain; Region: rve; pfam00665 216592024161 Integrase core domain; Region: rve_3; pfam13683 216592024162 HMMPfam hit to PF00665, Integrase core domain, score 1.2e-32 216592024163 IS2 repressor TnpA; Reviewed; Region: PRK09413 216592024164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024165 HMMPfam hit to PF01527, Transposase, score 2.7e-34 216592024167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216592024168 ATP binding site [chemical binding]; other site 216592024169 putative Mg++ binding site [ion binding]; other site 216592024170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216592024171 nucleotide binding region [chemical binding]; other site 216592024172 ATP-binding site [chemical binding]; other site 216592024173 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 8.2e-08 216592024174 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 1.5e-27 216592024175 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.4e-18 216592024176 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 216592024177 DNA methylase; Region: N6_N4_Mtase; cl17433 216592024178 PS00092 N-6 Adenine-specific DNA methylases signature. 216592024179 HNH endonuclease; Region: HNH_2; pfam13391 216592024180 Domain of unknown function (DUF303); Region: DUF303; pfam03629 216592024181 HMMPfam hit to PF03629, Domain of unknown function (DUF303), score 3e-55 216592024182 Predicted helix-turn-helix motif with score 1047.000, SD 2.75 at aa 48-69, sequence PRIKQLARFAHTHPGGPSCHFN 216592024183 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 216592024184 Kelch motif; Region: Kelch_1; pfam01344 216592024185 HMMPfam hit to PF01344, Kelch motif, score 0.53 216592024186 HMMPfam hit to PF01344, Kelch motif, score 2.2e-09 216592024187 HMMPfam hit to PF07646, Kelch motif, score 1e-06 216592024188 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 216592024189 HMMPfam hit to PF06178, Oligogalacturonate-specific porin protein (K, score 3.7e-124 216592024191 1 probable transmembrane helix predicted for EC042_4823 by TMHMM2.0 at aa 47-69 216592024192 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 216592024193 HMMPfam hit to PF03400, IS1 transposase, score 5.9e-113 216592024194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592024195 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592024196 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592024197 HMMPfam hit to PF03811, Insertion element protein, score 9e-68 216592024198 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592024199 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024200 fructuronate transporter; Provisional; Region: PRK10034 216592024201 gluconate transporter; Region: gntP; TIGR00791 216592024202 13 probable transmembrane helices predicted for EC042_4826 by TMHMM2.0 at aa 4-21, 28-50, 55-74, 95-117, 122-144, 174-196, 227-249, 261-283, 298-315, 328-350, 354-373, 380-402 and 424-446 216592024203 HMMPfam hit to PF02447, GntP family permease, score 3.2e-261 216592024204 mannonate dehydratase; Region: uxuA; TIGR00695 216592024205 mannonate dehydratase; Provisional; Region: PRK03906 216592024206 HMMPfam hit to PF03786, D-mannonate dehydratase (UxuA), score 3.7e-291 216592024207 D-mannonate oxidoreductase; Provisional; Region: PRK15037 216592024208 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216592024209 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216592024210 HMMPfam hit to PF01232, Mannitol dehydrogenase, score 1.5e-261 216592024211 PS00974 Mannitol dehydrogenases signature. 216592024212 Predicted helix-turn-helix motif with score 984.000, SD 2.54 at aa 235-256, sequence ETLQEIADQLGVYDPCAIACEP 216592024213 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 216592024214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592024215 DNA-binding site [nucleotide binding]; DNA binding site 216592024216 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592024217 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.1e-28 216592024218 PS00043 Bacterial regulatory proteins, gntR family signature. 216592024219 HMMPfam hit to PF07729, FCD domain, score 9e-39 216592024221 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 216592024222 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 5.6e-36 216592024223 cell density-dependent motility repressor; Provisional; Region: PRK10082 216592024224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216592024225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216592024226 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-25 216592024227 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.7e-14 216592024228 PS00044 Bacterial regulatory proteins, lysR family signature. 216592024229 Predicted helix-turn-helix motif with score 1201.000, SD 3.28 at aa 26-47, sequence RNFSQAAVSRNVSQPAFSRRIR 216592024230 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 216592024231 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 216592024232 dimer interface [polypeptide binding]; other site 216592024233 active site 216592024234 HMMPfam hit to PF01979, Amidohydrolase family, score 0.0035 216592024235 hypothetical protein; Provisional; Region: PRK10519 216592024236 3 probable transmembrane helices predicted for EC042_4835 by TMHMM2.0 at aa 20-42, 68-90 and 130-152 216592024237 HMMPfam hit to PF07670, Nucleoside recognition, score 4e-13 216592024238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 216592024239 Nucleoside recognition; Region: Gate; pfam07670 216592024240 HMMPfam hit to PF07670, Nucleoside recognition, score 1.9e-12 216592024241 4 probable transmembrane helices predicted for EC042_4836 by TMHMM2.0 at aa 21-43, 84-103, 116-138 and 183-205 216592024242 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 216592024243 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 216592024244 HMMPfam hit to PF01885, RNA 2'-phosphotransferase, Tpt1 / KptA fami, score 7.6e-107 216592024245 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 216592024246 12 probable transmembrane helices predicted for EC042_4838 by TMHMM2.0 at aa 12-34, 54-76, 83-105, 109-131, 138-160, 170-192, 212-234, 244-266, 271-293, 298-320, 333-355 and 360-382 216592024247 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2e-16 216592024248 HMMPfam hit to PF06779, Protein of unknown function (DUF1228), score 2e-47 216592024249 SdiA-regulated; Region: SdiA-regulated; pfam06977 216592024250 SdiA-regulated; Region: SdiA-regulated; cd09971 216592024251 putative active site [active] 216592024252 HMMPfam hit to PF06977, SdiA-regulated, score 1.5e-48 216592024253 2 probable transmembrane helices predicted for EC042_4839 by TMHMM2.0 at aa 21-38 and 48-65 216592024254 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 216592024255 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 216592024256 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 216592024257 HMMPfam hit to PF01869, BadF/BadG/BcrA/BcrD ATPase family, score 1.1e-96 216592024258 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 216592024259 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 216592024260 HMMPfam hit to PF06050, 2-hydroxyglutaryl-CoA dehydratase, D-compone, score 1.4e-165 216592024261 Predicted membrane protein [Function unknown]; Region: COG2733 216592024262 3 probable transmembrane helices predicted for EC042_4843 by TMHMM2.0 at aa 57-76, 86-106 and 442-464 216592024263 HMMPfam hit to PF04286, Protein of unknown function (DUF445), score 2e-168 216592024264 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 216592024265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592024266 putative substrate translocation pore; other site 216592024267 12 probable transmembrane helices predicted for EC042_4844 by TMHMM2.0 at aa 20-42, 57-79, 91-110, 114-136, 148-170, 174-196, 226-248, 263-285, 292-314, 319-341, 354-376 and 386-405 216592024268 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.1e-30 216592024269 PS00216 Sugar transport proteins signature 1. 216592024270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592024271 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592024272 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592024273 HMMPfam hit to PF03811, Insertion element protein, score 5.8e-67 216592024274 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024275 Predicted helix-turn-helix motif with score 1178.000, SD 3.20 at aa 64-85, sequence VGCRASARIMGVGLNTVLRHLK 216592024277 HMMPfam hit to PF03400, IS1 transposase, score 3.5e-28 216592024278 Protein of unknown function (DUF497); Region: DUF497; cl01108 216592024279 HMMPfam hit to PF04365, Protein of unknown function (DUF497), score 2e-23 216592024280 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 216592024281 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 216592024282 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 216592024283 P-loop, Walker A motif; other site 216592024284 Base recognition motif; other site 216592024285 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216592024286 HMMPfam hit to PF07683, Cobalamin synthesis protein cobW C-terminal, score 8.2e-35 216592024287 HMMPfam hit to PF02492, CobW/HypB/UreG, nucleotide-binding domain, score 2.1e-77 216592024288 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024289 carbon starvation protein A; Provisional; Region: PRK15015 216592024290 Carbon starvation protein CstA; Region: CstA; pfam02554 216592024291 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 216592024292 16 probable transmembrane helices predicted for EC042_4851 by TMHMM2.0 at aa 12-34, 39-61, 94-116, 126-145, 166-188, 198-220, 225-247, 262-284, 291-310, 330-352, 369-391, 491-510, 537-556, 571-593, 600-622 and 671-693 216592024293 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 5.7e-290 216592024294 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 216592024295 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 216592024296 dimer interface [polypeptide binding]; other site 216592024297 ligand binding site [chemical binding]; other site 216592024298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592024299 dimerization interface [polypeptide binding]; other site 216592024300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216592024301 dimer interface [polypeptide binding]; other site 216592024302 putative CheW interface [polypeptide binding]; other site 216592024303 2 probable transmembrane helices predicted for EC042_4852 by TMHMM2.0 at aa 7-29 and 192-214 216592024304 HMMPfam hit to PF02203, Tar ligand binding domain homologue, score 3.8e-69 216592024305 HMMPfam hit to PF00672, HAMP domain, score 5.8e-17 216592024306 PS00538 Bacterial chemotaxis sensory transducers signature. 216592024307 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.4e-123 216592024308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592024309 D-galactonate transporter; Region: 2A0114; TIGR00893 216592024310 putative substrate translocation pore; other site 216592024311 11 probable transmembrane helices predicted for EC042_4853 by TMHMM2.0 at aa 39-56, 72-94, 109-131, 169-191, 195-217, 260-282, 297-319, 332-354, 358-380, 393-415 and 421-443 216592024312 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.8e-72 216592024313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216592024314 DNA-binding site [nucleotide binding]; DNA binding site 216592024315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216592024316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216592024317 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216592024318 HMMPfam hit to PF07729, FCD domain, score 4.5e-05 216592024319 Predicted helix-turn-helix motif with score 1971.000, SD 5.90 at aa 29-50, sequence PSQSALAEMYNISRTTVRHILS 216592024320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216592024321 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 216592024322 putative NAD(P) binding site [chemical binding]; other site 216592024323 catalytic Zn binding site [ion binding]; other site 216592024324 structural Zn binding site [ion binding]; other site 216592024325 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 5.5e-91 216592024326 PS00059 Zinc-containing alcohol dehydrogenases signature. 216592024327 phosphoglycerol transferase I; Provisional; Region: PRK03776 216592024328 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 216592024329 HMMPfam hit to PF00884, Sulfatase, score 9.1e-10 216592024330 4 probable transmembrane helices predicted for EC042_4856 by TMHMM2.0 at aa 4-19, 26-48, 76-98 and 105-127 216592024331 hypothetical protein; Provisional; Region: PRK11667 216592024332 DNA replication protein DnaC; Validated; Region: PRK07952 216592024333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592024334 Walker A motif; other site 216592024335 ATP binding site [chemical binding]; other site 216592024336 Walker B motif; other site 216592024337 primosomal protein DnaI; Provisional; Region: PRK02854 216592024338 hypothetical protein; Provisional; Region: PRK09917 216592024339 4 probable transmembrane helices predicted for EC042_4860 by TMHMM2.0 at aa 20-42, 57-79, 92-114 and 134-156 216592024340 Uncharacterized conserved protein [Function unknown]; Region: COG2966 216592024341 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 216592024342 4 probable transmembrane helices predicted for EC042_4861 by TMHMM2.0 at aa 158-175, 188-210, 215-237 and 250-272 216592024343 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 2e-80 216592024344 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216592024345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592024346 DNA binding residues [nucleotide binding] 216592024347 dimerization interface [polypeptide binding]; other site 216592024348 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 5.6e-06 216592024349 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 169-190, sequence WGINQIASLLKKSNKTISAQKN 216592024350 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 216592024351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216592024352 DNA binding residues [nucleotide binding] 216592024353 dimerization interface [polypeptide binding]; other site 216592024354 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 2.3e-13 216592024355 Predicted helix-turn-helix motif with score 1011.000, SD 2.63 at aa 168-189, sequence YSMTQIAEQLKRNIKTIRAHKF 216592024356 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 216592024357 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 216592024358 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 216592024359 HMMPfam hit to PF06276, Ferric iron reductase protein FhuF, score 6.2e-151 216592024360 PS00294 Prenyl group binding site (CAAX box). 216592024361 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 216592024362 HMMPfam hit to PF07256, Protein of unknown function (DUF1435), score 1.1e-53 216592024363 3 probable transmembrane helices predicted for EC042_4865 by TMHMM2.0 at aa 43-65, 69-86 and 93-112 216592024364 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 216592024365 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 216592024366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592024367 S-adenosylmethionine binding site [chemical binding]; other site 216592024368 HMMPfam hit to PF05175, Methyltransferase small domain, score 7.1e-22 216592024369 PS00092 N-6 Adenine-specific DNA methylases signature. 216592024370 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.4e-12 216592024371 DNA polymerase III subunit psi; Validated; Region: PRK06856 216592024372 HMMPfam hit to PF03603, DNA polymerase III psi subunit, score 2.2e-63 216592024373 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 216592024374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216592024375 Coenzyme A binding pocket [chemical binding]; other site 216592024376 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-23 216592024377 dUMP phosphatase; Provisional; Region: PRK09449 216592024378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592024379 motif II; other site 216592024380 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-29 216592024381 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 216592024382 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 216592024383 G1 box; other site 216592024384 putative GEF interaction site [polypeptide binding]; other site 216592024385 GTP/Mg2+ binding site [chemical binding]; other site 216592024386 Switch I region; other site 216592024387 G2 box; other site 216592024388 G3 box; other site 216592024389 Switch II region; other site 216592024390 G4 box; other site 216592024391 G5 box; other site 216592024392 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 216592024393 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.8e-60 216592024394 PS00301 GTP-binding elongation factors signature. 216592024395 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.6e-13 216592024396 periplasmic protein; Provisional; Region: PRK10568 216592024397 BON domain; Region: BON; pfam04972 216592024398 BON domain; Region: BON; pfam04972 216592024399 1 probable transmembrane helix predicted for EC042_4872 by TMHMM2.0 at aa 21-43 216592024400 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 4.9e-17 216592024401 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 2.1e-14 216592024402 HMMPfam hit to PF07043, Protein of unknown function (DUF1328), score 4.2e-23 216592024403 2 probable transmembrane helices predicted for EC042_4873 by TMHMM2.0 at aa 12-34 and 38-57 216592024404 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 216592024405 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 216592024406 active site 216592024407 nucleophile elbow; other site 216592024408 HMMPfam hit to PF01734, Patatin-like phospholipase, score 4.6e-34 216592024409 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216592024410 active site 216592024411 HMMPfam hit to PF01026, TatD related DNase, score 4.2e-101 216592024412 PS01137 Uncharacterized protein family UPF0006 signature 1. 216592024413 PS01090 Uncharacterized protein family UPF0006 signature 2. 216592024414 PS01091 Uncharacterized protein family UPF0006 signature 3. 216592024415 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 216592024416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216592024417 FeS/SAM binding site; other site 216592024418 HMMPfam hit to PF04055, Radical SAM superfamily, score 5.6e-12 216592024419 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.015 216592024420 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592024421 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 4.9e-05 216592024422 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216592024423 PS01087 Radical activating enzymes signature. 216592024424 PS00190 Cytochrome c family heme-binding site signature. 216592024425 hypothetical protein; Provisional; Region: PRK10977 216592024426 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 216592024427 intersubunit interface [polypeptide binding]; other site 216592024428 active site 216592024429 catalytic residue [active] 216592024430 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase, score 1.4e-102 216592024431 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 216592024432 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216592024433 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216592024434 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 216592024435 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 4e-25 216592024436 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 8.2e-86 216592024437 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 216592024438 phosphopentomutase; Provisional; Region: PRK05362 216592024439 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 216592024440 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 8.2e-48 216592024441 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 216592024442 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 216592024443 HMMPfam hit to PF01048, Phosphorylase family, score 3.1e-118 216592024444 PS01232 Purine and other phosphorylases family 1 signature. 216592024445 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216592024446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592024447 non-specific DNA binding site [nucleotide binding]; other site 216592024448 salt bridge; other site 216592024449 sequence-specific DNA binding site [nucleotide binding]; other site 216592024450 HMMPfam hit to PF01381, Helix-turn-helix, score 2.1e-07 216592024451 Predicted helix-turn-helix motif with score 1715.000, SD 5.03 at aa 32-53, sequence LSLAEVSKMLGISINSLKQIEK 216592024452 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 216592024453 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 216592024454 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 216592024455 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 4.6e-33 216592024456 hypothetical protein; Provisional; Region: PRK11246 216592024457 1 probable transmembrane helix predicted for EC042_4884 by TMHMM2.0 at aa 13-32 216592024458 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 216592024459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216592024460 motif II; other site 216592024461 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.5e-27 216592024462 DNA repair protein RadA; Region: sms; TIGR00416 216592024463 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 216592024464 Walker A motif/ATP binding site; other site 216592024465 ATP binding site [chemical binding]; other site 216592024466 Walker B motif; other site 216592024467 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216592024468 PS00190 Cytochrome c family heme-binding site signature. 216592024469 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216592024471 non-specific DNA binding site [nucleotide binding]; other site 216592024472 salt bridge; other site 216592024473 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 216592024474 sequence-specific DNA binding site [nucleotide binding]; other site 216592024475 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 216592024476 active site 216592024477 (T/H)XGH motif; other site 216592024478 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 216592024479 HMMPfam hit to PF01381, Helix-turn-helix, score 2.8e-09 216592024480 Predicted helix-turn-helix motif with score 1877.000, SD 5.58 at aa 23-44, sequence CTLQQVADASGMTKGYLSQLLN 216592024481 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024482 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216592024483 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 216592024484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216592024485 Walker A/P-loop; other site 216592024486 ATP binding site [chemical binding]; other site 216592024487 Q-loop/lid; other site 216592024488 ABC transporter signature motif; other site 216592024489 Walker B; other site 216592024490 D-loop; other site 216592024491 H-loop/switch region; other site 216592024492 ABC transporter; Region: ABC_tran_2; pfam12848 216592024493 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216592024494 HMMPfam hit to PF00005, ABC transporter, score 3.7e-49 216592024495 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024496 HMMPfam hit to PF00005, ABC transporter, score 3.3e-57 216592024497 PS00211 ABC transporters family signature. 216592024498 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024499 lytic murein transglycosylase; Provisional; Region: PRK11619 216592024500 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592024501 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592024502 catalytic residue [active] 216592024503 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.7e-46 216592024504 PS00922 Prokaryotic transglycosylases signature. 216592024505 Trp operon repressor; Provisional; Region: PRK01381 216592024506 HMMPfam hit to PF01371, Trp repressor protein, score 6e-41 216592024507 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 216592024508 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 2.8e-118 216592024509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216592024510 catalytic core [active] 216592024511 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 1.2e-83 216592024512 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 216592024513 1 probable transmembrane helix predicted for EC042_4892 by TMHMM2.0 at aa 146-168 216592024514 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 216592024515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592024516 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 216592024517 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 1.5e-26 216592024518 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 5.8e-09 216592024519 PS00041 Bacterial regulatory proteins, araC family signature. 216592024520 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1e-10 216592024521 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 22-43, sequence LSLDNVAAKAGYSKWHLQRMFK 216592024522 hypothetical protein; Provisional; Region: PRK10756 216592024523 CreA protein; Region: CreA; pfam05981 216592024524 HMMPfam hit to PF05981, CreA protein, score 1.5e-98 216592024525 DNA-binding response regulator CreB; Provisional; Region: PRK11083 216592024526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592024527 active site 216592024528 phosphorylation site [posttranslational modification] 216592024529 intermolecular recognition site; other site 216592024530 dimerization interface [polypeptide binding]; other site 216592024531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592024532 DNA binding site [nucleotide binding] 216592024533 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-37 216592024534 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 8.1e-21 216592024535 sensory histidine kinase CreC; Provisional; Region: PRK11100 216592024536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216592024537 dimerization interface [polypeptide binding]; other site 216592024538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216592024539 dimer interface [polypeptide binding]; other site 216592024540 phosphorylation site [posttranslational modification] 216592024541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216592024542 ATP binding site [chemical binding]; other site 216592024543 Mg2+ binding site [ion binding]; other site 216592024544 G-X-G motif; other site 216592024545 2 probable transmembrane helices predicted for EC042_4896 by TMHMM2.0 at aa 5-27 and 184-206 216592024546 HMMPfam hit to PF00672, HAMP domain, score 1.5e-13 216592024547 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.5e-16 216592024548 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.9e-31 216592024549 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 216592024550 HMMPfam hit to PF06123, Inner membrane protein CreD, score 6e-277 216592024551 5 probable transmembrane helices predicted for EC042_4897 by TMHMM2.0 at aa 10-32, 298-317, 321-343, 350-372 and 402-424 216592024552 two-component response regulator; Provisional; Region: PRK11173 216592024553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216592024554 active site 216592024555 phosphorylation site [posttranslational modification] 216592024556 intermolecular recognition site; other site 216592024557 dimerization interface [polypeptide binding]; other site 216592024558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216592024559 DNA binding site [nucleotide binding] 216592024560 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.1e-18 216592024561 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-35 216592024562 putative RNA methyltransferase; Provisional; Region: PRK10433 216592024563 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 216592024564 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 1.7e-54 216592024565 replication protein; Provisional; Region: PRK13750 216592024566 HMMPfam hit to PF02387, IncFII_repA, score 7e-08 216592024568 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 216592024569 substrate binding pocket [chemical binding]; other site 216592024570 aspartate-rich region 2; other site 216592024571 substrate-Mg2+ binding site; other site 216592024572 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 216592024573 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 216592024574 active site 216592024575 metal binding site [ion binding]; metal-binding site 216592024576 nudix motif; other site 216592024577 HMMPfam hit to PF00293, NUDIX, score 2.3e-16 216592024578 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216592024579 hit to IS1203 1..421 score: 1901 percent id: 94.77 216592024581 HMMPfam hit to PF01527, Transposase_8, score 1.8e-13 216592024582 Predicted helix-turn-helix motif with score 1470.000, SD 4.19 at aa 31-52, sequence AVICSIAPKIGCTPETLRVWVR 216592024583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216592024584 4 probable transmembrane helices predicted for EC042_pAA007 by TMHMM2.0 at aa 22-44, 248-270, 303-325 and 340-362 216592024585 Outer membrane efflux protein; Region: OEP; pfam02321 216592024586 Signal peptide predicted for EC042_pAA008 by SignalP 2.0 HMM (Signal peptide probability 0.929) with cleavage site probability 0.926 between residues 22 and 23 216592024587 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 216592024588 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216592024589 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 216592024590 Walker A/P-loop; other site 216592024591 ATP binding site [chemical binding]; other site 216592024592 Q-loop/lid; other site 216592024593 ABC transporter signature motif; other site 216592024594 Walker B; other site 216592024595 D-loop; other site 216592024596 H-loop/switch region; other site 216592024597 HMMPfam hit to PF00005, ABC_tran, score 1.2e-40 216592024598 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024599 PS00211 ABC transporters family signature. 216592024600 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 216592024601 4 probable transmembrane helices predicted for EC042_pAA011 by TMHMM2.0 at aa 22-44, 51-73, 86-108 and 121-143 216592024602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024604 HMMPfam hit to PF03050, Transposase_25, score 1.5e-129 216592024605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592024606 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216592024607 HMMPfam hit to PF05717, Transposase_34, score 1.1e-67 216592024608 Transposase; Region: HTH_Tnp_1; pfam01527 216592024609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024610 HMMPfam hit to PF01527, Transposase_8, score 2.2e-24 216592024611 Phage integrase family; Region: Phage_integrase; pfam00589 216592024612 active site 216592024613 DNA binding site [nucleotide binding] 216592024614 Int/Topo IB signature motif; other site 216592024615 HMMPfam hit to PF00589, Phage_integrase, score 3.9e-50 216592024616 Predicted helix-turn-helix motif with score 1562.000, SD 4.51 at aa 161-182, sequence TGRTEKARIWEVTDRTVRIWIG 216592024617 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 216592024618 HMMPfam hit to PF01845, CcdB, score 3.9e-91 216592024619 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 216592024620 HMMPfam hit to PF07362, CcdA, score 2e-54 216592024622 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 216592024623 putative active site [active] 216592024624 putative metal binding site [ion binding]; other site 216592024625 HMMPfam hit to PF01522, Polysacc_deac_1, score 5.4e-45 216592024626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216592024627 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216592024628 HMMPfam hit to PF00534, Glycos_transf_1, score 8.2e-19 216592024629 Protein of unknown function (DUF535); Region: DUF535; pfam04393 216592024630 HMMPfam hit to PF04393, DUF535, score 5.7e-149 216592024632 HMMPfam hit to PF05717, Transposase_34, score 4.4e-37 216592024634 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 216592024635 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 216592024636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216592024637 Walker A motif; other site 216592024638 ATP binding site [chemical binding]; other site 216592024639 HMMPfam hit to PF01695, IstB, score 2.8e-74 216592024640 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024641 HMMPfam hit to PF08483, IstB_N, score 4.3e-14 216592024642 hit to IS1203 1..1310 score: 6136 percent id: 96.49 216592024643 putative transposase OrfB; Reviewed; Region: PHA02517 216592024644 HTH-like domain; Region: HTH_21; pfam13276 216592024645 Integrase core domain; Region: rve; pfam00665 216592024646 Integrase core domain; Region: rve_3; pfam13683 216592024647 HMMPfam hit to PF00665, rve, score 3.6e-45 216592024648 Transposase; Region: HTH_Tnp_1; cl17663 216592024649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024650 HMMPfam hit to PF01527, Transposase_8, score 8.3e-12 216592024651 Predicted helix-turn-helix motif with score 1328.000, SD 3.71 at aa 31-52, sequence AAICSIAPKIGCTPETLRVWVR 216592024653 HMMPfam hit to PF00665, rve, score 5.5e-31 216592024654 PS00019 Actinin-type actin-binding domain signature 1. 216592024655 PS00294 Prenyl group binding site (CAAX box). 216592024656 Enterobacteria AfaD invasin protein; Region: AfaD; pfam05775 216592024657 HMMPfam hit to PF05775, AfaD, score 8.9e-104 216592024658 Signal peptide predicted for EC042_pAA030 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 23 and 24 216592024659 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 216592024660 PapC N-terminal domain; Region: PapC_N; pfam13954 216592024661 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 216592024662 PapC C-terminal domain; Region: PapC_C; pfam13953 216592024663 HMMPfam hit to PF00577, Usher, score 0 216592024664 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216592024665 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216592024667 HMMPfam hit to PF02753, Pili_assembly_C, score 0.00013 216592024668 HMMPfam hit to PF00345, Pili_assembly_N, score 1e-13 216592024669 hit to IS1A 1..768 score: 3804 percent id: 99.48; IS1A 216592024670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592024671 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592024672 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592024673 HMMPfam hit to PF03811, Ins_element1, score 7.7e-68 216592024674 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024675 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592024676 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 216592024677 HMMPfam hit to PF03400, Transposase_27, score 1.1e-103 216592024678 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 216592024679 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 216592024680 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 216592024681 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216592024682 Autotransporter beta-domain; Region: Autotransporter; pfam03797 216592024683 Signal peptide predicted for EC042_pAA035 by SignalP 2.0 HMM (Signal peptide probability 0.856) with cleavage site probability 0.396 between residues 23 and 24 216592024684 1 probable transmembrane helix predicted for EC042_pAA035 by TMHMM2.0 at aa 34-53 216592024685 HMMPfam hit to PF02395, Peptidase_S6, score 0 216592024686 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024687 HMMPfam hit to PF03797, Autotransporter, score 2.4e-43 216592024689 HMMPfam hit to PF00872, Transposase_mut, score 1.9e-66 216592024690 PS01007 Transposases, Mutator family, signature. 216592024691 HMMPfam hit to PF00872, Transposase_mut, score 6.3e-40 216592024692 IS629 216592024693 Transposase; Region: HTH_Tnp_1; cl17663 216592024694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024695 HMMPfam hit to PF01527, Transposase_8, score 8.3e-12 216592024696 Predicted helix-turn-helix motif with score 1328.000, SD 3.71 at aa 31-52, sequence AAICSIAPKIGCTPETLRVWVR 216592024697 putative transposase OrfB; Reviewed; Region: PHA02517 216592024698 HTH-like domain; Region: HTH_21; pfam13276 216592024699 Integrase core domain; Region: rve; pfam00665 216592024700 Integrase core domain; Region: rve_3; pfam13683 216592024701 HMMPfam hit to PF00665, rve, score 3.6e-45 216592024702 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216592024703 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216592024704 P-loop; other site 216592024705 Magnesium ion binding site [ion binding]; other site 216592024707 HMMPfam hit to PF00665, rve, score 1.4e-42 216592024708 IS30 216592024710 HMMPfam hit to PF01527, Transposase_8, score 5.8e-08 216592024712 HMMPfam hit to PF00665, rve, score 2.9e-05 216592024713 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 216592024714 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216592024715 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216592024716 Signal peptide predicted for EC042_pAA046 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.999 between residues 22 and 23 216592024717 HMMPfam hit to PF00345, Pili_assembly_N, score 5.8e-62 216592024718 PS00635 Gram-negative pili assembly chaperone signature. 216592024719 HMMPfam hit to PF02753, Pili_assembly_C, score 4.9e-21 216592024720 Signal peptide predicted for EC042_pAA048 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.887 between residues 25 and 26 216592024721 hit to IS1414 1054..1123 score: 314 percent id: 94.29 216592024723 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 216592024724 HMMPfam hit to PF03400, Transposase_27, score 3.1e-112 216592024725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 216592024726 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 216592024727 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 216592024728 HMMPfam hit to PF03811, Ins_element1, score 7.7e-68 216592024729 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 64-85, sequence VGCRATARIMGVGLNTILRHLK 216592024730 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024731 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216592024732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216592024733 HMMPfam hit to PF00165, HTH_AraC, score 1.7e-12 216592024734 PS00041 Bacterial regulatory proteins, araC family signature. 216592024735 HMMPfam hit to PF00165, HTH_AraC, score 0.00025 216592024736 Predicted helix-turn-helix motif with score 1775.000, SD 5.23 at aa 178-199, sequence WTLAIIADEFNVSEITIRKRLE 216592024739 hit to IS3E 1120..1181 score: 256 percent id: 90.32 216592024740 Signal peptide predicted for EC042_pAA055 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 21 and 22 216592024742 HMMPfam hit to PF00665, rve, score 1.6e-21 216592024743 Predicted helix-turn-helix motif with score 1094.000, SD 2.91 at aa 23-44, sequence SNVSKACKIMGVSRDTFYRYRE 216592024745 HMMPfam hit to PF00665, rve, score 3.1e-23 216592024746 Transposase; Region: HTH_Tnp_1; cl17663 216592024747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024748 HMMPfam hit to PF01527, Transposase_8, score 3.8e-17 216592024749 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 216592024750 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216592024751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592024752 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216592024753 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216592024754 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216592024755 HMMPfam hit to PF03050, Transposase_25, score 4.1e-129 216592024756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216592024757 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216592024758 HMMPfam hit to PF05717, Transposase_34, score 1.1e-69 216592024759 Transposase; Region: HTH_Tnp_1; pfam01527 216592024760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024761 HMMPfam hit to PF01527, Transposase_8, score 2e-22 216592024762 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 216592024763 hit to IS1414 1..213 score: 1038 percent id: 98.59 216592024765 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 216592024766 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 216592024767 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 216592024768 putative RNA binding sites [nucleotide binding]; other site 216592024769 HMMPfam hit to PF05286, FINO, score 3.4e-125 216592024770 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 216592024771 5 probable transmembrane helices predicted for EC042_pAA067 by TMHMM2.0 at aa 102-124, 144-166, 179-196,200-219 and 226-247 216592024772 HMMPfam hit to PF05857, TraX, score 1.3e-82 216592024773 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 216592024774 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 216592024775 AAA domain; Region: AAA_30; pfam13604 216592024776 DNA helicase TraI; Region: TraI; pfam07057 216592024777 HMMPfam hit to PF07057, TraI, score 4.1e-100 216592024778 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024779 HMMPfam hit to PF08751, TrwC, score 3.6e-139 216592024780 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 216592024781 F sex factor protein N terminal; Region: TraD_N; pfam12615 216592024782 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 216592024783 multimer interface [polypeptide binding]; other site 216592024784 Walker A motif; other site 216592024785 ATP binding site [chemical binding]; other site 216592024786 Walker B motif; other site 216592024787 HMMPfam hit to PF02534, TraG, score 0.00062 216592024788 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024789 2 probable transmembrane helices predicted for EC042_pAA069 by TMHMM2.0 at aa 25-47 and 108-130 216592024790 1 probable transmembrane helix predicted for EC042_pAA070 by TMHMM2.0 at aa 47-69 216592024791 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 216592024792 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 216592024793 HMMPfam hit to PF05818, TraT, score 1.9e-195 216592024794 1 probable transmembrane helix predicted for EC042_pAA071 by TMHMM2.0 at aa 21-43 216592024795 Signal peptide predicted for EC042_pAA071 by SignalP 2.0 HMM (Signal peptide probability 0.984) with cleavage site probability 0.409 between residues 40 and 41 216592024796 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024797 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 216592024798 3 probable transmembrane helices predicted for EC042_pAA072 by TMHMM2.0 at aa 4-21, 28-50 and 65-87 216592024799 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 216592024800 HMMPfam hit to PF07916, TraG_N, score 5.1e-231 216592024801 2 probable transmembrane helices predicted for EC042_pAA073 by TMHMM2.0 at aa 327-349 and 356-378 216592024802 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 216592024803 HMMPfam hit to PF06122, TraH, score 6.8e-219 216592024804 PS00214 Cytosolic fatty-acid binding proteins signature. 216592024805 Signal peptide predicted for EC042_pAA074 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.704 between residues 23 and 24 216592024806 conjugal transfer protein TrbF; Provisional; Region: PRK13743 216592024807 2 probable transmembrane helices predicted for EC042_pAA075 by TMHMM2.0 at aa 29-51 and 71-93 216592024808 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 216592024809 2 probable transmembrane helices predicted for EC042_pAA076 by TMHMM2.0 at aa 7-29 and 44-66 216592024810 Signal peptide predicted for EC042_pAA076 by SignalP 2.0 HMM (Signal peptide probability 0.902) with cleavage site probability 0.644 between residues 19 and 20 216592024811 conjugal transfer protein TrbB; Provisional; Region: PRK13728 216592024812 Signal peptide predicted for EC042_pAA077 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.989 between residues 20 and 21 216592024813 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 216592024814 2 probable transmembrane helices predicted for EC042_pAA078 by TMHMM2.0 at aa 12-34 and 38-60 216592024815 conjugal transfer protein TrbA; Provisional; Region: PRK13712 216592024816 4 probable transmembrane helices predicted for EC042_pAA079 by TMHMM2.0 at aa 5-27, 34-53, 57-79 and 91-109 216592024817 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 216592024818 F plasmid transfer operon protein; Region: TraF; pfam13728 216592024819 Signal peptide predicted for EC042_pAA080 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 19 and 20 216592024820 conjugal transfer protein TrbE; Provisional; Region: PRK13718 216592024821 2 probable transmembrane helices predicted for EC042_pAA081 by TMHMM2.0 at aa 13-31 and 46-68 216592024822 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 216592024823 HMMPfam hit to PF06986, TraN, score 1.1e-13 216592024824 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024825 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024826 Signal peptide predicted for EC042_pAA082 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.995 between residues 18 and 19 216592024827 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 216592024828 Signal peptide predicted for EC042_pAA083 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 21 and 22 216592024829 2 probable transmembrane helices predicted for EC042_pAA084 by TMHMM2.0 at aa 20-42 and 70-92 216592024830 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 216592024831 HMMPfam hit to PF06834, TraU, score 2.6e-223 216592024832 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024833 Signal peptide predicted for EC042_pAA085 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.471 between residues 22 and 23 216592024834 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 216592024835 Signal peptide predicted for EC042_pAA086 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.824 between residues 18 and 19 216592024836 conjugal transfer protein TrbI; Provisional; Region: PRK13717 216592024837 1 probable transmembrane helix predicted for EC042_pAA087 by TMHMM2.0 at aa 20-42 216592024838 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 216592024839 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 216592024840 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024841 conjugal transfer protein TraR; Provisional; Region: PRK13715 216592024842 HMMPfam hit to PF01258, zf-dskA_traR, score 4e-39 216592024843 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 216592024844 conjugal transfer protein TraV; Provisional; Region: PRK13733 216592024845 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 216592024846 Signal peptide predicted for EC042_pAA090 by SignalP 2.0 HMM (Signal peptide probability 0.983) with cleavage site probability 0.549 between residues 22 and 23 216592024847 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024848 conjugal transfer protein TrbD; Provisional; Region: PRK13724 216592024849 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024850 conjugal transfer protein TraP; Provisional; Region: PRK13739 216592024851 HMMPfam hit to PF07296, TraP, score 4.4e-107 216592024852 2 probable transmembrane helices predicted for EC042_pAA092 by TMHMM2.0 at aa 19-41 and 106-128 216592024853 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 216592024854 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 216592024855 HMMPfam hit to PF06447, TraB_pillus, score 1.1e-213 216592024856 1 probable transmembrane helix predicted for EC042_pAA093 by TMHMM2.0 at aa 13-32 216592024857 Signal peptide predicted for EC042_pAA093 by SignalP 2.0 HMM (Signal peptide probability 0.911) with cleavage site probability 0.395 between residues 28 and 29 216592024858 conjugal transfer protein TraK; Provisional; Region: PRK13736 216592024859 TraK protein; Region: TraK; pfam06586 216592024860 HMMPfam hit to PF06586, TraK, score 1.9e-189 216592024861 1 probable transmembrane helix predicted for EC042_pAA094 by TMHMM2.0 at aa 7-29 216592024862 Signal peptide predicted for EC042_pAA094 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 between residues 21 and 22 216592024863 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024864 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 216592024865 HMMPfam hit to PF05309, TraE, score 1.4e-128 216592024866 1 probable transmembrane helix predicted for EC042_pAA095 by TMHMM2.0 at aa 10-32 216592024867 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 216592024868 HMMPfam hit to PF07178, TraL, score 6.7e-35 216592024869 1 probable transmembrane helix predicted for EC042_pAA096 by TMHMM2.0 at aa 38-60 216592024870 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 216592024871 HMMPfam hit to PF05513, TraA, score 5.8e-79 216592024872 3 probable transmembrane helices predicted for EC042_pAA097 by TMHMM2.0 at aa 29-51, 77-94 and 101-120 216592024873 Signal peptide predicted for EC042_pAA097 by SignalP 2.0 HMM (Signal peptide probability 0.998) with cleavage site probability 0.947 between residues 51 and 52 216592024874 conjugal transfer protein TraY; Provisional; Region: PRK13740 216592024875 HMMPfam hit to PF05509, TraY, score 3.6e-37 216592024876 PAS fold; Region: PAS; pfam00989 216592024877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216592024878 HMMPfam hit to PF00989, PAS, score 2.3e-20 216592024879 TraM protein; Region: Tra_M; pfam05261 216592024880 HMMPfam hit to PF05261, Tra_M, score 1.5e-88 216592024881 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216592024882 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216592024883 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216592024884 catalytic residue [active] 216592024885 Signal peptide predicted for EC042_pAA101 by SignalP 2.0 HMM (Signal peptide probability 0.990) with cleavage site probability 0.988 between residues 19 and 20 216592024886 HMMPfam hit to PF01464, SLT, score 4.2e-42 216592024887 Domain of unknown function (DUF932); Region: DUF932; pfam06067 216592024888 HMMPfam hit to PF06067, DUF932, score 1.1e-225 216592024889 excinuclease ABC subunit B; Provisional; Region: PRK05298 216592024891 1 probable transmembrane helix predicted for EC042_pAA105 by TMHMM2.0 at aa 47-69 216592024893 small toxic polypeptide; Provisional; Region: PRK09738 216592024894 modulator of post-segregation killing protein; Provisional; Region: PRK13720 216592024895 HMMPfam hit to PF01848, HOK_GEF, score 1.2e-22 216592024896 1 probable transmembrane helix predicted for EC042_pAA106 by TMHMM2.0 at aa 4-26 216592024897 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 216592024898 HMMPfam hit to PF06952, PsiA, score 3e-177 216592024899 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 216592024900 HMMPfam hit to PF06290, PsiB, score 1.5e-124 216592024901 ParB-like nuclease domain; Region: ParB; smart00470 216592024902 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 216592024903 KorB domain; Region: KorB; pfam08535 216592024904 Predicted helix-turn-helix motif with score 1473.000, SD 4.20 at aa 156-177, sequence KTPAQIGDLLGYSPRHVQRMLK 216592024905 PS00017 ATP/GTP-binding site motif A (P-loop). 216592024906 HMMPfam hit to PF02195, ParBc, score 3.6e-28 216592024907 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 216592024908 HMMPfam hit to PF06006, DUF905, score 3.4e-47 216592024909 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216592024910 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216592024911 dimer interface [polypeptide binding]; other site 216592024912 ssDNA binding site [nucleotide binding]; other site 216592024913 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216592024914 HMMPfam hit to PF00436, SSB, score 1.2e-32 216592024915 PS00736 Single-strand binding protein family signature 2. 216592024916 PS00735 Single-strand binding protein family signature 1. 216592024918 Signal peptide predicted for EC042_pAA119 by SignalP 2.0 HMM (Signal peptide probability 0.997) with cleavage site probability 0.946 between residues 27 and 28 216592024919 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216592024920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216592024921 S-adenosylmethionine binding site [chemical binding]; other site 216592024922 PS00092 N-6 Adenine-specific DNA methylases signature. 216592024923 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 216592024924 1 probable transmembrane helix predicted for EC042_pAA127 by TMHMM2.0 at aa 91-110 216592024925 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 216592024926 Antirestriction protein; Region: Antirestrict; pfam03230 216592024927 HMMPfam hit to PF03230, Antirestrict, score 1.9e-62 216592024929 HMMPfam hit to PF07339, DUF1472, score 8.4e-46 216592024930 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 216592024931 HMMPfam hit to PF07128, DUF1380, score 4.6e-114 216592024932 putative methylase; Provisional; Region: PRK13699 216592024933 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216592024934 HMMPfam hit to PF01555, N6_N4_Mtase, score 1.5e-52 216592024935 PS00092 N-6 Adenine-specific DNA methylases signature. 216592024937 1 probable transmembrane helix predicted for EC042_pAA135 by TMHMM2.0 at aa 2-24 216592024938 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 216592024939 nucleotide binding site [chemical binding]; other site 216592024940 putative protofilament interface [polypeptide binding]; other site 216592024941 HMMPfam hit to PF06406, StbA, score 2.9e-237 216592024942 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 216592024944 HMMPfam hit to PF00239, Resolvase, score 8.1e-09 216592024945 HMMPfam hit to PF02796, HTH_7, score 2.2e-11 216592024947 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216592024948 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 216592024949 intersubunit interface [polypeptide binding]; other site 216592024950 Signal peptide predicted for EC042_pAA142 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.947 between residues 20 and 21 216592024951 1 probable transmembrane helix predicted for EC042_pAA142 by TMHMM2.0 at aa 5-27 216592024952 HMMPfam hit to PF01497, Peripla_BP_2, score 4.8e-22 216592024954 HMMPfam hit to PF01032, FecCD, score 5.8e-10 216592024956 HMMPfam hit to PF00005, ABC_tran, score 2e-28 216592024957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216592024958 11 probable transmembrane helices predicted for EC042_pAA145 by TMHMM2.0 at aa 15-37, 44-66, 104-126,147-169, 173-195, 215-237, 252-274, 281-303, 308-330,350-372 and 382-404 216592024959 HMMPfam hit to PF07690, MFS_1, score 2.8e-31 216592024961 HMMPfam hit to PF01320, Colicin_Pyocin, score 3.5e-41 216592024962 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216592024963 HMMPfam hit to PF05016, Plasmid_stabil, score 3.5e-12 216592024964 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00014 Endoplasmic reticulum targeting sequence. 216592024966 replication protein; Provisional; Region: PRK13750 216592024967 HMMPfam hit to PF02387, IncFII_repA, score 7e-08 216592024968 replication protein; Provisional; Region: PRK13702 216592024969 hit to IS1414 1..639 score: 3150 percent id: 99.22 216592024971 HMMPfam hit to PF00872, Transposase_mut, score 4.4e-53 216592024972 putative transposase OrfB; Reviewed; Region: PHA02517 216592024973 HTH-like domain; Region: HTH_21; pfam13276 216592024974 Integrase core domain; Region: rve; pfam00665 216592024975 Integrase core domain; Region: rve_3; pfam13683 216592024976 HMMPfam hit to PF00665, rve, score 3.6e-45 216592024978 HMMPfam hit to PF01527, Transposase_8, score 4e-09 216592024979 Predicted helix-turn-helix motif with score 1328.000, SD 3.71 at aa 45-66, sequence AAICSIAPKIGCTPETLRVWVR 216592024980 putative transposase OrfB; Reviewed; Region: PHA02517 216592024981 HTH-like domain; Region: HTH_21; pfam13276 216592024982 Integrase core domain; Region: rve; pfam00665 216592024983 Integrase core domain; Region: rve_3; pfam13683 216592024984 HMMPfam hit to PF00665, rve, score 2.9e-45 216592024985 Transposase; Region: HTH_Tnp_1; cl17663 216592024986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216592024987 HMMPfam hit to PF01527, Transposase_8, score 4.5e-13 216592024988 Predicted helix-turn-helix motif with score 1711.000, SD 5.01 at aa 31-52, sequence ATICSIAPKIGCTPETLRVWVR 216592024989 hit to IS1414 1..649 score: 3203 percent id: 99.38 216592024990 HMMPfam hit to PF00872, Transposase_mut, score 4e-55 216592024991 replication protein; Provisional; Region: PRK13702