-- dump date 20140619_080711 -- class Genbank::misc_feature -- table misc_feature_note -- id note 362663000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 362663000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 362663000003 putative catalytic residues [active] 362663000004 putative nucleotide binding site [chemical binding]; other site 362663000005 putative aspartate binding site [chemical binding]; other site 362663000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 362663000007 dimer interface [polypeptide binding]; other site 362663000008 putative threonine allosteric regulatory site; other site 362663000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 362663000010 putative threonine allosteric regulatory site; other site 362663000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 362663000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 362663000013 homoserine kinase; Region: thrB; TIGR00191 362663000014 Protein of unknown function; Region: YhfT; pfam10797 362663000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362663000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 362663000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 362663000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663000019 catalytic residue [active] 362663000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 362663000021 hypothetical protein; Validated; Region: PRK02101 362663000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 362663000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 362663000024 transaldolase-like protein; Provisional; Region: PTZ00411 362663000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 362663000026 active site 362663000027 dimer interface [polypeptide binding]; other site 362663000028 catalytic residue [active] 362663000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 362663000030 MPT binding site; other site 362663000031 trimer interface [polypeptide binding]; other site 362663000032 hypothetical protein; Provisional; Region: PRK10659 362663000033 hypothetical protein; Provisional; Region: PRK10236 362663000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 362663000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 362663000036 hypothetical protein; Provisional; Region: PRK10154 362663000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 362663000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 362663000039 nucleotide binding site [chemical binding]; other site 362663000040 NEF interaction site [polypeptide binding]; other site 362663000041 SBD interface [polypeptide binding]; other site 362663000042 chaperone protein DnaJ; Provisional; Region: PRK10767 362663000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 362663000044 HSP70 interaction site [polypeptide binding]; other site 362663000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 362663000046 substrate binding site [polypeptide binding]; other site 362663000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 362663000048 Zn binding sites [ion binding]; other site 362663000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 362663000050 dimer interface [polypeptide binding]; other site 362663000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 362663000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 362663000053 Sulfatase; Region: Sulfatase; pfam00884 362663000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 362663000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 362663000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 362663000058 putative dimerization interface [polypeptide binding]; other site 362663000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 362663000060 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 362663000061 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 362663000062 active site 362663000063 Riboflavin kinase; Region: Flavokinase; smart00904 362663000064 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 362663000065 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 362663000066 HIGH motif; other site 362663000067 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 362663000068 active site 362663000069 KMSKS motif; other site 362663000070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 362663000071 tRNA binding surface [nucleotide binding]; other site 362663000072 anticodon binding site; other site 362663000073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 362663000074 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 362663000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 362663000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362663000077 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 362663000078 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 362663000079 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 362663000080 active site 362663000081 tetramer interface [polypeptide binding]; other site 362663000082 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 362663000083 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 362663000084 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 362663000085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 362663000086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 362663000087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 362663000088 catalytic site [active] 362663000089 subunit interface [polypeptide binding]; other site 362663000090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 362663000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362663000092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 362663000093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 362663000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362663000095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 362663000096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 362663000097 IMP binding site; other site 362663000098 dimer interface [polypeptide binding]; other site 362663000099 interdomain contacts; other site 362663000100 partial ornithine binding site; other site 362663000101 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 362663000102 carnitine operon protein CaiE; Provisional; Region: PRK13627 362663000103 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 362663000104 putative trimer interface [polypeptide binding]; other site 362663000105 putative metal binding site [ion binding]; other site 362663000106 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 362663000107 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362663000108 substrate binding site [chemical binding]; other site 362663000109 oxyanion hole (OAH) forming residues; other site 362663000110 trimer interface [polypeptide binding]; other site 362663000111 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 362663000112 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 362663000113 acyl-activating enzyme (AAE) consensus motif; other site 362663000114 putative AMP binding site [chemical binding]; other site 362663000115 putative active site [active] 362663000116 putative CoA binding site [chemical binding]; other site 362663000117 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 362663000118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 362663000119 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 362663000120 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 362663000121 active site 362663000122 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 362663000123 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 362663000124 Ligand binding site [chemical binding]; other site 362663000125 Electron transfer flavoprotein domain; Region: ETF; pfam01012 362663000126 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 362663000127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 362663000128 Ligand binding site [chemical binding]; other site 362663000129 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 362663000130 putative oxidoreductase FixC; Provisional; Region: PRK10157 362663000131 ferredoxin-like protein FixX; Provisional; Region: PRK15449 362663000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663000133 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 362663000134 putative substrate translocation pore; other site 362663000135 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 362663000136 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 362663000137 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 362663000138 TrkA-N domain; Region: TrkA_N; pfam02254 362663000139 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 362663000140 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 362663000141 folate binding site [chemical binding]; other site 362663000142 NADP+ binding site [chemical binding]; other site 362663000143 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 362663000144 CcdB protein; Region: CcdB; pfam01845 362663000145 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 362663000146 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 362663000147 active site 362663000148 metal binding site [ion binding]; metal-binding site 362663000149 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 362663000150 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 362663000151 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 362663000152 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 362663000153 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 362663000154 peptidyl-prolyl cis-trans isomerase nonfunction due to the frame shift 362663000155 peptidyl-prolyl cis-trans isomerase nonfunction due to the frame shift 362663000156 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 362663000157 OstA-like protein; Region: OstA; pfam03968 362663000158 Organic solvent tolerance protein; Region: OstA_C; pfam04453 362663000159 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 362663000160 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 362663000161 putative metal binding site [ion binding]; other site 362663000162 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 362663000163 HSP70 interaction site [polypeptide binding]; other site 362663000164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 362663000165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362663000166 active site 362663000167 ATP-dependent helicase HepA; Validated; Region: PRK04914 362663000168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663000169 ATP binding site [chemical binding]; other site 362663000170 putative Mg++ binding site [ion binding]; other site 362663000171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663000172 nucleotide binding region [chemical binding]; other site 362663000173 ATP-binding site [chemical binding]; other site 362663000174 DNA polymerase II; Reviewed; Region: PRK05762 362663000175 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 362663000176 active site 362663000177 catalytic site [active] 362663000178 substrate binding site [chemical binding]; other site 362663000179 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 362663000180 active site 362663000181 metal-binding site 362663000182 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 362663000183 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 362663000184 intersubunit interface [polypeptide binding]; other site 362663000185 active site 362663000186 Zn2+ binding site [ion binding]; other site 362663000187 L-arabinose isomerase; Provisional; Region: PRK02929 362663000188 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 362663000189 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 362663000190 trimer interface [polypeptide binding]; other site 362663000191 putative substrate binding site [chemical binding]; other site 362663000192 putative metal binding site [ion binding]; other site 362663000193 ribulokinase; Provisional; Region: PRK04123 362663000194 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 362663000195 N- and C-terminal domain interface [polypeptide binding]; other site 362663000196 active site 362663000197 MgATP binding site [chemical binding]; other site 362663000198 catalytic site [active] 362663000199 metal binding site [ion binding]; metal-binding site 362663000200 carbohydrate binding site [chemical binding]; other site 362663000201 homodimer interface [polypeptide binding]; other site 362663000202 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 362663000203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362663000204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663000206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362663000207 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 362663000208 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 362663000209 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 362663000210 Walker A/P-loop; other site 362663000211 ATP binding site [chemical binding]; other site 362663000212 Q-loop/lid; other site 362663000213 ABC transporter signature motif; other site 362663000214 Walker B; other site 362663000215 D-loop; other site 362663000216 H-loop/switch region; other site 362663000217 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 362663000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663000219 dimer interface [polypeptide binding]; other site 362663000220 conserved gate region; other site 362663000221 putative PBP binding loops; other site 362663000222 ABC-ATPase subunit interface; other site 362663000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663000224 dimer interface [polypeptide binding]; other site 362663000225 conserved gate region; other site 362663000226 putative PBP binding loops; other site 362663000227 ABC-ATPase subunit interface; other site 362663000228 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 362663000229 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 362663000230 transcriptional regulator SgrR; Provisional; Region: PRK13626 362663000231 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 362663000232 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 362663000233 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 362663000234 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 362663000235 substrate binding site [chemical binding]; other site 362663000236 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 362663000237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 362663000238 substrate binding site [chemical binding]; other site 362663000239 ligand binding site [chemical binding]; other site 362663000240 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 362663000241 tartrate dehydrogenase; Region: TTC; TIGR02089 362663000242 2-isopropylmalate synthase; Validated; Region: PRK00915 362663000243 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 362663000244 active site 362663000245 catalytic residues [active] 362663000246 metal binding site [ion binding]; metal-binding site 362663000247 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 362663000248 leu operon leader peptide; Provisional; Region: PRK09925 362663000249 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 362663000250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663000251 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 362663000252 putative substrate binding pocket [chemical binding]; other site 362663000253 putative dimerization interface [polypeptide binding]; other site 362663000254 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 362663000255 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362663000256 PYR/PP interface [polypeptide binding]; other site 362663000257 dimer interface [polypeptide binding]; other site 362663000258 TPP binding site [chemical binding]; other site 362663000259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663000260 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 362663000261 TPP-binding site [chemical binding]; other site 362663000262 dimer interface [polypeptide binding]; other site 362663000263 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 362663000264 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 362663000265 putative valine binding site [chemical binding]; other site 362663000266 dimer interface [polypeptide binding]; other site 362663000267 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 362663000268 similar to fruR/shl operon leader peptide 362663000269 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 362663000270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663000271 DNA binding site [nucleotide binding] 362663000272 domain linker motif; other site 362663000273 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 362663000274 dimerization interface [polypeptide binding]; other site 362663000275 ligand binding site [chemical binding]; other site 362663000276 mraZ protein; Region: TIGR00242 362663000277 MraZ protein; Region: MraZ; pfam02381 362663000278 MraZ protein; Region: MraZ; pfam02381 362663000279 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 362663000280 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 362663000281 cell division protein FtsL; Provisional; Region: PRK10772 362663000282 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 362663000283 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 362663000284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 362663000285 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 362663000286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362663000287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663000288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663000289 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 362663000290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362663000291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663000292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663000293 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 362663000294 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 362663000295 Mg++ binding site [ion binding]; other site 362663000296 putative catalytic motif [active] 362663000297 putative substrate binding site [chemical binding]; other site 362663000298 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 362663000299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663000300 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663000301 cell division protein FtsW; Provisional; Region: PRK10774 362663000302 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 362663000303 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 362663000304 active site 362663000305 homodimer interface [polypeptide binding]; other site 362663000306 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 362663000307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362663000308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663000309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663000310 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 362663000311 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 362663000312 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 362663000313 cell division protein FtsQ; Provisional; Region: PRK10775 362663000314 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 362663000315 Cell division protein FtsQ; Region: FtsQ; pfam03799 362663000316 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 362663000317 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663000318 Cell division protein FtsA; Region: FtsA; pfam14450 362663000319 cell division protein FtsZ; Validated; Region: PRK09330 362663000320 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 362663000321 nucleotide binding site [chemical binding]; other site 362663000322 SulA interaction site; other site 362663000323 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 362663000324 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 362663000325 SecA regulator SecM; Provisional; Region: PRK02943 362663000326 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 362663000327 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 362663000328 SEC-C motif; Region: SEC-C; pfam02810 362663000329 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 362663000330 active site 362663000331 8-oxo-dGMP binding site [chemical binding]; other site 362663000332 nudix motif; other site 362663000333 metal binding site [ion binding]; metal-binding site 362663000334 DNA gyrase inhibitor; Reviewed; Region: PRK00418 362663000335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 362663000336 dephospho-CoA kinase; Region: TIGR00152 362663000337 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 362663000338 CoA-binding site [chemical binding]; other site 362663000339 ATP-binding [chemical binding]; other site 362663000340 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 362663000341 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 362663000342 active site 362663000343 type IV pilin biogenesis protein; Provisional; Region: PRK10573 362663000344 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663000346 hypothetical protein; Provisional; Region: PRK10436 362663000347 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 362663000348 Walker A motif; other site 362663000349 ATP binding site [chemical binding]; other site 362663000350 Walker B motif; other site 362663000351 putative major pilin subunit; Provisional; Region: PRK10574 362663000352 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 362663000353 Pilin (bacterial filament); Region: Pilin; pfam00114 362663000354 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 362663000355 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 362663000356 dimerization interface [polypeptide binding]; other site 362663000357 active site 362663000358 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 362663000359 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 362663000360 amidase catalytic site [active] 362663000361 Zn binding residues [ion binding]; other site 362663000362 substrate binding site [chemical binding]; other site 362663000363 regulatory protein AmpE; Provisional; Region: PRK10987 362663000364 aromatic amino acid transporter; Provisional; Region: PRK10238 362663000365 Protein of unknown function (DUF796); Region: DUF796; cl01226 362663000366 S-type Pyocin; Region: Pyocin_S; pfam06958 362663000367 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 362663000368 active site 362663000369 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 362663000370 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 362663000371 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 362663000372 Transcriptional regulators [Transcription]; Region: FadR; COG2186 362663000373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663000374 DNA-binding site [nucleotide binding]; DNA binding site 362663000375 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663000376 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 362663000377 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 362663000378 dimer interface [polypeptide binding]; other site 362663000379 TPP-binding site [chemical binding]; other site 362663000380 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 362663000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362663000382 E3 interaction surface; other site 362663000383 lipoyl attachment site [posttranslational modification]; other site 362663000384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362663000385 E3 interaction surface; other site 362663000386 lipoyl attachment site [posttranslational modification]; other site 362663000387 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362663000388 E3 interaction surface; other site 362663000389 lipoyl attachment site [posttranslational modification]; other site 362663000390 e3 binding domain; Region: E3_binding; pfam02817 362663000391 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 362663000392 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 362663000393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 362663000394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663000395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 362663000396 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 362663000397 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 362663000398 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 362663000399 substrate binding site [chemical binding]; other site 362663000400 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 362663000401 substrate binding site [chemical binding]; other site 362663000402 ligand binding site [chemical binding]; other site 362663000403 hypothetical protein; Provisional; Region: PRK05248 362663000404 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 362663000405 spermidine synthase; Provisional; Region: PRK00811 362663000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663000407 S-adenosylmethionine binding site [chemical binding]; other site 362663000408 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 362663000409 multicopper oxidase; Provisional; Region: PRK10965 362663000410 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 362663000411 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 362663000412 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 362663000413 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 362663000414 Trp docking motif [polypeptide binding]; other site 362663000415 putative active site [active] 362663000416 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663000417 active site 362663000418 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 362663000419 active site clefts [active] 362663000420 zinc binding site [ion binding]; other site 362663000421 dimer interface [polypeptide binding]; other site 362663000422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362663000423 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362663000424 Walker A/P-loop; other site 362663000425 ATP binding site [chemical binding]; other site 362663000426 Q-loop/lid; other site 362663000427 ABC transporter signature motif; other site 362663000428 Walker B; other site 362663000429 D-loop; other site 362663000430 H-loop/switch region; other site 362663000431 inner membrane transport permease; Provisional; Region: PRK15066 362663000432 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362663000433 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362663000434 active pocket/dimerization site; other site 362663000435 active site 362663000436 phosphorylation site [posttranslational modification] 362663000437 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 362663000438 putative active site [active] 362663000439 putative metal binding site [ion binding]; other site 362663000440 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 362663000441 tetramerization interface [polypeptide binding]; other site 362663000442 active site 362663000443 Uncharacterized conserved protein [Function unknown]; Region: COG5464 362663000444 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 362663000445 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 362663000446 pantoate--beta-alanine ligase; Region: panC; TIGR00018 362663000447 Pantoate-beta-alanine ligase; Region: PanC; cd00560 362663000448 active site 362663000449 ATP-binding site [chemical binding]; other site 362663000450 pantoate-binding site; other site 362663000451 HXXH motif; other site 362663000452 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 362663000453 oligomerization interface [polypeptide binding]; other site 362663000454 active site 362663000455 metal binding site [ion binding]; metal-binding site 362663000456 Fimbrial protein; Region: Fimbrial; cl01416 362663000457 Fimbrial protein; Region: Fimbrial; cl01416 362663000458 putative fimbrial protein StaF; Provisional; Region: PRK15262 362663000459 putative fimbrial protein StaE; Provisional; Region: PRK15263 362663000460 Fimbrial protein; Region: Fimbrial; cl01416 362663000461 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 362663000462 PapC N-terminal domain; Region: PapC_N; pfam13954 362663000463 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663000464 PapC C-terminal domain; Region: PapC_C; pfam13953 362663000465 putative chaperone protein EcpD; Provisional; Region: PRK09926 362663000466 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663000467 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663000468 Fimbrial protein; Region: Fimbrial; cl01416 362663000469 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 362663000470 catalytic center binding site [active] 362663000471 ATP binding site [chemical binding]; other site 362663000472 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 362663000473 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 362663000474 active site 362663000475 NTP binding site [chemical binding]; other site 362663000476 metal binding triad [ion binding]; metal-binding site 362663000477 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 362663000478 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 362663000479 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 362663000480 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 362663000481 active site 362663000482 nucleotide binding site [chemical binding]; other site 362663000483 HIGH motif; other site 362663000484 KMSKS motif; other site 362663000485 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 362663000486 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 362663000487 2'-5' RNA ligase; Provisional; Region: PRK15124 362663000488 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 362663000489 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 362663000490 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 362663000491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663000492 ATP binding site [chemical binding]; other site 362663000493 putative Mg++ binding site [ion binding]; other site 362663000494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663000495 nucleotide binding region [chemical binding]; other site 362663000496 ATP-binding site [chemical binding]; other site 362663000497 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 362663000498 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 362663000499 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 362663000500 Transglycosylase; Region: Transgly; pfam00912 362663000501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 362663000502 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 362663000503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663000504 N-terminal plug; other site 362663000505 ligand-binding site [chemical binding]; other site 362663000506 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 362663000507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663000508 Walker A/P-loop; other site 362663000509 ATP binding site [chemical binding]; other site 362663000510 Q-loop/lid; other site 362663000511 ABC transporter signature motif; other site 362663000512 Walker B; other site 362663000513 D-loop; other site 362663000514 H-loop/switch region; other site 362663000515 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 362663000516 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 362663000517 siderophore binding site; other site 362663000518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663000519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663000520 ABC-ATPase subunit interface; other site 362663000521 dimer interface [polypeptide binding]; other site 362663000522 putative PBP binding regions; other site 362663000523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663000524 ABC-ATPase subunit interface; other site 362663000525 dimer interface [polypeptide binding]; other site 362663000526 putative PBP binding regions; other site 362663000527 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 362663000528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663000529 inhibitor-cofactor binding pocket; inhibition site 362663000530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663000531 catalytic residue [active] 362663000532 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 362663000533 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 362663000534 Cl- selectivity filter; other site 362663000535 Cl- binding residues [ion binding]; other site 362663000536 pore gating glutamate residue; other site 362663000537 dimer interface [polypeptide binding]; other site 362663000538 H+/Cl- coupling transport residue; other site 362663000539 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 362663000540 hypothetical protein; Provisional; Region: PRK10578 362663000541 UPF0126 domain; Region: UPF0126; pfam03458 362663000542 UPF0126 domain; Region: UPF0126; pfam03458 362663000543 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 362663000544 intersubunit interface [polypeptide binding]; other site 362663000545 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 362663000546 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 362663000547 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 362663000548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362663000549 Zn2+ binding site [ion binding]; other site 362663000550 Mg2+ binding site [ion binding]; other site 362663000551 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 362663000552 serine endoprotease; Provisional; Region: PRK10942 362663000553 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 362663000554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663000555 protein binding site [polypeptide binding]; other site 362663000556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663000557 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 362663000558 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 362663000559 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 362663000560 hypothetical protein; Provisional; Region: PRK13677 362663000561 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 362663000562 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 362663000563 trimer interface [polypeptide binding]; other site 362663000564 active site 362663000565 substrate binding site [chemical binding]; other site 362663000566 CoA binding site [chemical binding]; other site 362663000567 PII uridylyl-transferase; Provisional; Region: PRK05007 362663000568 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 362663000569 metal binding triad; other site 362663000570 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 362663000571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362663000572 Zn2+ binding site [ion binding]; other site 362663000573 Mg2+ binding site [ion binding]; other site 362663000574 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 362663000575 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 362663000576 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 362663000577 active site 362663000578 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 362663000579 rRNA interaction site [nucleotide binding]; other site 362663000580 S8 interaction site; other site 362663000581 putative laminin-1 binding site; other site 362663000582 elongation factor Ts; Provisional; Region: tsf; PRK09377 362663000583 UBA/TS-N domain; Region: UBA; pfam00627 362663000584 Elongation factor TS; Region: EF_TS; pfam00889 362663000585 Elongation factor TS; Region: EF_TS; pfam00889 362663000586 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 362663000587 putative nucleotide binding site [chemical binding]; other site 362663000588 uridine monophosphate binding site [chemical binding]; other site 362663000589 homohexameric interface [polypeptide binding]; other site 362663000590 ribosome recycling factor; Reviewed; Region: frr; PRK00083 362663000591 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 362663000592 hinge region; other site 362663000593 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 362663000594 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 362663000595 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 362663000596 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 362663000597 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 362663000598 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 362663000599 catalytic residue [active] 362663000600 putative FPP diphosphate binding site; other site 362663000601 putative FPP binding hydrophobic cleft; other site 362663000602 dimer interface [polypeptide binding]; other site 362663000603 putative IPP diphosphate binding site; other site 362663000604 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 362663000605 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 362663000606 zinc metallopeptidase RseP; Provisional; Region: PRK10779 362663000607 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 362663000608 active site 362663000609 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 362663000610 protein binding site [polypeptide binding]; other site 362663000611 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 362663000612 putative substrate binding region [chemical binding]; other site 362663000613 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 362663000614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663000615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663000616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663000617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663000619 Surface antigen; Region: Bac_surface_Ag; pfam01103 362663000620 periplasmic chaperone; Provisional; Region: PRK10780 362663000621 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 362663000622 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 362663000623 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 362663000624 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 362663000625 trimer interface [polypeptide binding]; other site 362663000626 active site 362663000627 UDP-GlcNAc binding site [chemical binding]; other site 362663000628 lipid binding site [chemical binding]; lipid-binding site 362663000629 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 362663000630 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 362663000631 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 362663000632 active site 362663000633 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 362663000634 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 362663000635 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 362663000636 RNA/DNA hybrid binding site [nucleotide binding]; other site 362663000637 active site 362663000638 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 362663000639 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 362663000640 putative active site [active] 362663000641 putative PHP Thumb interface [polypeptide binding]; other site 362663000642 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 362663000643 generic binding surface II; other site 362663000644 generic binding surface I; other site 362663000645 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 362663000646 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 362663000647 lysine decarboxylase LdcC; Provisional; Region: PRK15399 362663000648 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663000649 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663000650 homodimer interface [polypeptide binding]; other site 362663000651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663000652 catalytic residue [active] 362663000653 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663000654 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 362663000655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 362663000656 putative metal binding site [ion binding]; other site 362663000657 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 362663000658 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 362663000659 Ligand Binding Site [chemical binding]; other site 362663000660 TilS substrate binding domain; Region: TilS; pfam09179 362663000661 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 362663000662 Rho-binding antiterminator; Provisional; Region: PRK11625 362663000663 hypothetical protein; Provisional; Region: PRK04964 362663000664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 362663000665 hypothetical protein; Provisional; Region: PRK09256 362663000666 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 362663000667 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 362663000668 NlpE N-terminal domain; Region: NlpE; pfam04170 362663000669 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 362663000670 hypothetical protein; Provisional; Region: PRK11479 362663000671 prolyl-tRNA synthetase; Provisional; Region: PRK09194 362663000672 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 362663000673 dimer interface [polypeptide binding]; other site 362663000674 motif 1; other site 362663000675 active site 362663000676 motif 2; other site 362663000677 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 362663000678 putative deacylase active site [active] 362663000679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 362663000680 active site 362663000681 motif 3; other site 362663000682 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 362663000683 anticodon binding site; other site 362663000684 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 362663000685 homodimer interaction site [polypeptide binding]; other site 362663000686 cofactor binding site; other site 362663000687 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 362663000688 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 362663000689 lipoprotein, YaeC family; Region: TIGR00363 362663000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663000691 dimer interface [polypeptide binding]; other site 362663000692 conserved gate region; other site 362663000693 ABC-ATPase subunit interface; other site 362663000694 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 362663000695 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 362663000696 Walker A/P-loop; other site 362663000697 ATP binding site [chemical binding]; other site 362663000698 Q-loop/lid; other site 362663000699 ABC transporter signature motif; other site 362663000700 Walker B; other site 362663000701 D-loop; other site 362663000702 H-loop/switch region; other site 362663000703 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 362663000704 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 362663000705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663000706 active site 362663000707 motif I; other site 362663000708 motif II; other site 362663000709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663000710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663000711 active site 362663000712 catalytic tetrad [active] 362663000713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663000714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663000715 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 362663000716 putative effector binding pocket; other site 362663000717 dimerization interface [polypeptide binding]; other site 362663000718 hypothetical protein; Provisional; Region: PRK05421 362663000719 putative catalytic site [active] 362663000720 putative metal binding site [ion binding]; other site 362663000721 putative phosphate binding site [ion binding]; other site 362663000722 putative catalytic site [active] 362663000723 putative phosphate binding site [ion binding]; other site 362663000724 putative metal binding site [ion binding]; other site 362663000725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 362663000726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663000727 S-adenosylmethionine binding site [chemical binding]; other site 362663000728 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 362663000729 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663000730 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663000731 catalytic residue [active] 362663000732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663000733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663000734 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 362663000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663000736 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 362663000737 RNA/DNA hybrid binding site [nucleotide binding]; other site 362663000738 active site 362663000739 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 362663000740 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 362663000741 active site 362663000742 catalytic site [active] 362663000743 substrate binding site [chemical binding]; other site 362663000744 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 362663000745 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 362663000746 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 362663000747 ImpA domain protein; Region: DUF3702; pfam12486 362663000748 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 362663000749 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 362663000750 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 362663000751 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 362663000752 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 362663000753 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 362663000754 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 362663000755 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 362663000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663000757 Walker A motif; other site 362663000758 ATP binding site [chemical binding]; other site 362663000759 Walker B motif; other site 362663000760 arginine finger; other site 362663000761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663000762 Walker A motif; other site 362663000763 ATP binding site [chemical binding]; other site 362663000764 Walker B motif; other site 362663000765 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362663000766 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 362663000767 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 362663000768 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 362663000769 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 362663000770 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 362663000771 FHA domain; Region: FHA; pfam00498 362663000772 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 362663000773 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 362663000774 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 362663000775 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 362663000776 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 362663000777 Protein of unknown function (DUF877); Region: DUF877; pfam05943 362663000778 Protein of unknown function (DUF770); Region: DUF770; pfam05591 362663000779 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 362663000780 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 362663000781 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 362663000782 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 362663000783 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 362663000784 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 362663000785 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 362663000786 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 362663000787 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 362663000788 putative active site [active] 362663000789 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 362663000790 H repeat-associated protein of Rhs element 362663000791 Transposase [DNA replication, recombination, and repair]; Region: COG5433 362663000792 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 362663000793 C-N hydrolase family amidase; Provisional; Region: PRK10438 362663000794 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 362663000795 putative active site [active] 362663000796 catalytic triad [active] 362663000797 dimer interface [polypeptide binding]; other site 362663000798 multimer interface [polypeptide binding]; other site 362663000799 C-lysozyme inhibitor; Provisional; Region: PRK09993 362663000800 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 362663000801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 362663000802 active site 362663000803 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 362663000804 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 362663000805 dimer interface [polypeptide binding]; other site 362663000806 active site 362663000807 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 362663000808 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 362663000809 putative active site [active] 362663000810 putative dimer interface [polypeptide binding]; other site 362663000811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 362663000812 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663000813 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 362663000814 NlpC/P60 family; Region: NLPC_P60; pfam00877 362663000815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 362663000816 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 362663000817 FHIPEP family; Region: FHIPEP; pfam00771 362663000818 hypothetical protein; Validated; Region: PRK06778 362663000819 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663000820 ligand binding site [chemical binding]; other site 362663000821 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 362663000822 active site 362663000823 DNA polymerase IV; Validated; Region: PRK02406 362663000824 DNA binding site [nucleotide binding] 362663000825 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 362663000826 putative toxin YafO; Provisional; Region: PRK09885 362663000827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362663000828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663000829 Coenzyme A binding pocket [chemical binding]; other site 362663000830 hypothetical protein; Reviewed; Region: PRK09588 362663000831 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 362663000832 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 362663000833 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 362663000834 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 362663000835 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 362663000836 metal binding site [ion binding]; metal-binding site 362663000837 dimer interface [polypeptide binding]; other site 362663000838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663000839 active site 362663000840 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 362663000841 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 362663000842 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663000843 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663000844 trimer interface [polypeptide binding]; other site 362663000845 eyelet of channel; other site 362663000846 gamma-glutamyl kinase; Provisional; Region: PRK05429 362663000847 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 362663000848 nucleotide binding site [chemical binding]; other site 362663000849 homotetrameric interface [polypeptide binding]; other site 362663000850 putative phosphate binding site [ion binding]; other site 362663000851 putative allosteric binding site; other site 362663000852 PUA domain; Region: PUA; pfam01472 362663000853 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 362663000854 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 362663000855 putative catalytic cysteine [active] 362663000856 integrase; Provisional; Region: int; PHA02601 362663000857 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 362663000858 Int/Topo IB signature motif; other site 362663000859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663000860 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663000861 DNA-binding interface [nucleotide binding]; DNA binding site 362663000862 Integrase core domain; Region: rve; pfam00665 362663000863 transposase/IS protein; Provisional; Region: PRK09183 362663000864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663000865 Walker A motif; other site 362663000866 ATP binding site [chemical binding]; other site 362663000867 Walker B motif; other site 362663000868 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 362663000869 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 362663000870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362663000871 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362663000872 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822 362663000873 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 362663000874 putative transposase OrfB; Reviewed; Region: PHA02517 362663000875 Integrase core domain; Region: rve; pfam00665 362663000876 Integrase core domain; Region: rve_2; pfam13333 362663000877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663000878 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 362663000879 Walker A/P-loop; other site 362663000880 ATP binding site [chemical binding]; other site 362663000881 ABC transporter; Region: ABC_tran; pfam00005 362663000882 Q-loop/lid; other site 362663000883 ABC transporter signature motif; other site 362663000884 Walker B; other site 362663000885 D-loop; other site 362663000886 CAAX protease self-immunity; Region: Abi; pfam02517 362663000887 FaeA-like protein; Region: FaeA; pfam04703 362663000888 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 362663000889 Fimbrial protein; Region: Fimbrial; cl01416 362663000890 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663000891 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 362663000892 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663000893 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663000894 outer membrane usher protein; Provisional; Region: PRK15193 362663000895 PapC N-terminal domain; Region: PapC_N; pfam13954 362663000896 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663000897 PapC C-terminal domain; Region: PapC_C; pfam13953 362663000898 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663000899 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663000900 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 362663000901 mannosyl binding site [chemical binding]; other site 362663000902 Fimbrial protein; Region: Fimbrial; pfam00419 362663000903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663000904 MarR family; Region: MarR_2; cl17246 362663000905 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663000906 outer membrane receptor FepA; Provisional; Region: PRK13528 362663000907 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663000908 N-terminal plug; other site 362663000909 ligand-binding site [chemical binding]; other site 362663000910 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 362663000911 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 362663000912 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 362663000913 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 362663000914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663000915 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362663000916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663000917 Walker A/P-loop; other site 362663000918 ATP binding site [chemical binding]; other site 362663000919 Q-loop/lid; other site 362663000920 ABC transporter signature motif; other site 362663000921 Walker B; other site 362663000922 D-loop; other site 362663000923 H-loop/switch region; other site 362663000924 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 362663000925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663000926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663000927 Walker A/P-loop; other site 362663000928 ATP binding site [chemical binding]; other site 362663000929 Q-loop/lid; other site 362663000930 ABC transporter signature motif; other site 362663000931 Walker B; other site 362663000932 D-loop; other site 362663000933 H-loop/switch region; other site 362663000934 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 362663000935 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 362663000936 homodimer interface [polypeptide binding]; other site 362663000937 active site 362663000938 TDP-binding site; other site 362663000939 acceptor substrate-binding pocket; other site 362663000940 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 362663000941 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 362663000942 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663000943 N-terminal plug; other site 362663000944 ligand-binding site [chemical binding]; other site 362663000945 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 362663000946 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 362663000947 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 362663000948 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 362663000949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663000950 Integrase core domain; Region: rve; pfam00665 362663000951 transposase/IS protein; Provisional; Region: PRK09183 362663000952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663000953 Walker A motif; other site 362663000954 ATP binding site [chemical binding]; other site 362663000955 Walker B motif; other site 362663000956 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 362663000957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 362663000958 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 362663000959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 362663000960 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 362663000961 Transposase; Region: HTH_Tnp_1; cl17663 362663000962 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 362663000963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663000964 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 362663000965 putative dimerization interface [polypeptide binding]; other site 362663000966 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 362663000967 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 362663000968 dimer interface [polypeptide binding]; other site 362663000969 putative anticodon binding site; other site 362663000970 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 362663000971 motif 1; other site 362663000972 active site 362663000973 motif 2; other site 362663000974 motif 3; other site 362663000975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663000976 lysine decarboxylase LdcC; Provisional; Region: PRK15399 362663000977 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663000978 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663000979 homodimer interface [polypeptide binding]; other site 362663000980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663000981 catalytic residue [active] 362663000982 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663000983 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 362663000984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663000985 Transposase; Region: HTH_Tnp_1; pfam01527 362663000986 Predicted GTPase [General function prediction only]; Region: COG3596 362663000987 YfjP GTPase; Region: YfjP; cd11383 362663000988 G1 box; other site 362663000989 GTP/Mg2+ binding site [chemical binding]; other site 362663000990 Switch I region; other site 362663000991 G2 box; other site 362663000992 Switch II region; other site 362663000993 G3 box; other site 362663000994 G4 box; other site 362663000995 G5 box; other site 362663000996 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 362663000997 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 362663000998 hypothetical protein; Provisional; Region: PRK09945 362663000999 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 362663001000 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663001001 Autotransporter beta-domain; Region: Autotransporter; smart00869 362663001002 Domain of unknown function (DUF932); Region: DUF932; pfam06067 362663001003 Antirestriction protein; Region: Antirestrict; pfam03230 362663001004 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 362663001005 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663001006 MPN+ (JAMM) motif; other site 362663001007 Zinc-binding site [ion binding]; other site 362663001008 Protein of unknown function (DUF987); Region: DUF987; pfam06174 362663001009 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 362663001010 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 362663001011 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 362663001012 Methyltransferase domain; Region: Methyltransf_27; pfam13708 362663001013 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663001014 active site 362663001015 Int/Topo IB signature motif; other site 362663001016 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 362663001017 MarR family; Region: MarR_2; cl17246 362663001018 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663001019 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 362663001020 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 362663001021 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 362663001022 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663001023 Autotransporter beta-domain; Region: Autotransporter; pfam03797 362663001024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 362663001025 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 362663001026 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 362663001027 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 362663001028 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 362663001029 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 362663001030 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663001031 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 362663001032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663001033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663001034 DNA binding residues [nucleotide binding] 362663001035 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 362663001036 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 362663001037 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 362663001038 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 362663001039 putative active site [active] 362663001040 putative FMN binding site [chemical binding]; other site 362663001041 putative substrate binding site [chemical binding]; other site 362663001042 putative catalytic residue [active] 362663001043 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 362663001044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663001045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663001046 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 362663001047 putative effector binding pocket; other site 362663001048 putative dimerization interface [polypeptide binding]; other site 362663001049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663001050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663001051 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 362663001052 putative effector binding pocket; other site 362663001053 putative dimerization interface [polypeptide binding]; other site 362663001054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663001055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663001056 active site 362663001057 catalytic tetrad [active] 362663001058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663001059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663001060 active site 362663001061 catalytic tetrad [active] 362663001062 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 362663001063 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 362663001064 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 362663001065 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 362663001066 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 362663001067 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 362663001068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663001069 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 362663001070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663001071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663001072 active site 362663001073 catalytic tetrad [active] 362663001074 Predicted membrane protein [Function unknown]; Region: COG3059 362663001075 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663001076 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 362663001077 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 362663001078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663001079 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 362663001080 Cupin; Region: Cupin_6; pfam12852 362663001081 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 362663001082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663001083 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 362663001084 Cysteine-rich domain; Region: CCG; pfam02754 362663001085 Cysteine-rich domain; Region: CCG; pfam02754 362663001086 iron-sulfur cluster-binding protein; Region: TIGR00273 362663001087 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 362663001088 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663001089 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 362663001090 Uncharacterized conserved protein [Function unknown]; Region: COG1556 362663001091 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 362663001092 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 362663001093 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663001094 Autotransporter beta-domain; Region: Autotransporter; pfam03797 362663001095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663001096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663001097 DNA binding residues [nucleotide binding] 362663001098 dimerization interface [polypeptide binding]; other site 362663001099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663001100 active site 362663001101 DNA binding site [nucleotide binding] 362663001102 Int/Topo IB signature motif; other site 362663001103 choline dehydrogenase; Validated; Region: PRK02106 362663001104 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 362663001105 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 362663001106 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 362663001107 tetrameric interface [polypeptide binding]; other site 362663001108 NAD binding site [chemical binding]; other site 362663001109 catalytic residues [active] 362663001110 transcriptional regulator BetI; Validated; Region: PRK00767 362663001111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663001112 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 362663001113 choline transport protein BetT; Provisional; Region: PRK09928 362663001114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663001115 DNA binding residues [nucleotide binding] 362663001116 dimerization interface [polypeptide binding]; other site 362663001117 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663001118 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 362663001119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663001120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663001121 dimerization interface [polypeptide binding]; other site 362663001122 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 362663001123 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 362663001124 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 362663001125 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 362663001126 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 362663001127 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 362663001128 CoA binding domain; Region: CoA_binding; pfam02629 362663001129 CoA-ligase; Region: Ligase_CoA; pfam00549 362663001130 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 362663001131 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 362663001132 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 362663001133 putative substrate binding site [chemical binding]; other site 362663001134 nucleotide binding site [chemical binding]; other site 362663001135 nucleotide binding site [chemical binding]; other site 362663001136 homodimer interface [polypeptide binding]; other site 362663001137 putative deaminase; Validated; Region: PRK06846 362663001138 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 362663001139 active site 362663001140 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 362663001141 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 362663001142 putative NAD(P) binding site [chemical binding]; other site 362663001143 putative substrate binding site [chemical binding]; other site 362663001144 catalytic Zn binding site [ion binding]; other site 362663001145 structural Zn binding site [ion binding]; other site 362663001146 dimer interface [polypeptide binding]; other site 362663001147 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 362663001148 hypothetical protein; Provisional; Region: PRK09929 362663001149 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 362663001150 Propionate catabolism activator; Region: PrpR_N; pfam06506 362663001151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663001152 Walker A motif; other site 362663001153 ATP binding site [chemical binding]; other site 362663001154 Walker B motif; other site 362663001155 arginine finger; other site 362663001156 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663001157 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 362663001158 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 362663001159 tetramer interface [polypeptide binding]; other site 362663001160 active site 362663001161 Mg2+/Mn2+ binding site [ion binding]; other site 362663001162 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 362663001163 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 362663001164 dimer interface [polypeptide binding]; other site 362663001165 active site 362663001166 citrylCoA binding site [chemical binding]; other site 362663001167 oxalacetate/citrate binding site [chemical binding]; other site 362663001168 coenzyme A binding site [chemical binding]; other site 362663001169 catalytic triad [active] 362663001170 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 362663001171 2-methylcitrate dehydratase; Region: prpD; TIGR02330 362663001172 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 362663001173 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 362663001174 acyl-activating enzyme (AAE) consensus motif; other site 362663001175 putative AMP binding site [chemical binding]; other site 362663001176 putative active site [active] 362663001177 putative CoA binding site [chemical binding]; other site 362663001178 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 362663001179 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 362663001180 Na binding site [ion binding]; other site 362663001181 putative substrate binding site [chemical binding]; other site 362663001182 cytosine deaminase; Provisional; Region: PRK09230 362663001183 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 362663001184 active site 362663001185 Integrase core domain; Region: rve; pfam00665 362663001186 Integrase core domain; Region: rve_2; pfam13333 362663001187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663001188 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663001189 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663001190 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 362663001191 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 362663001192 active site 362663001193 substrate binding site [chemical binding]; other site 362663001194 trimer interface [polypeptide binding]; other site 362663001195 CoA binding site [chemical binding]; other site 362663001196 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 362663001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001198 putative substrate translocation pore; other site 362663001199 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 362663001200 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 362663001201 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 362663001202 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 362663001203 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 362663001204 lac repressor; Reviewed; Region: lacI; PRK09526 362663001205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663001206 DNA binding site [nucleotide binding] 362663001207 domain linker motif; other site 362663001208 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 362663001209 ligand binding site [chemical binding]; other site 362663001210 dimerization interface (open form) [polypeptide binding]; other site 362663001211 dimerization interface (closed form) [polypeptide binding]; other site 362663001212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 362663001213 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 362663001214 S-formylglutathione hydrolase; Region: PLN02442 362663001215 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 362663001216 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 362663001217 substrate binding site [chemical binding]; other site 362663001218 catalytic Zn binding site [ion binding]; other site 362663001219 NAD binding site [chemical binding]; other site 362663001220 structural Zn binding site [ion binding]; other site 362663001221 dimer interface [polypeptide binding]; other site 362663001222 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 362663001223 putative metal binding site [ion binding]; other site 362663001224 putative homodimer interface [polypeptide binding]; other site 362663001225 putative homotetramer interface [polypeptide binding]; other site 362663001226 putative homodimer-homodimer interface [polypeptide binding]; other site 362663001227 putative allosteric switch controlling residues; other site 362663001228 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362663001229 putative trimer interface [polypeptide binding]; other site 362663001230 putative CoA binding site [chemical binding]; other site 362663001231 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 362663001232 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 362663001233 DXD motif; other site 362663001234 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 362663001235 taurine-binding periplasmic protein 362663001236 taurine-binding periplasmic protein 362663001237 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 362663001238 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 362663001239 Walker A/P-loop; other site 362663001240 ATP binding site [chemical binding]; other site 362663001241 Q-loop/lid; other site 362663001242 ABC transporter signature motif; other site 362663001243 Walker B; other site 362663001244 D-loop; other site 362663001245 H-loop/switch region; other site 362663001246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 362663001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663001248 dimer interface [polypeptide binding]; other site 362663001249 conserved gate region; other site 362663001250 putative PBP binding loops; other site 362663001251 ABC-ATPase subunit interface; other site 362663001252 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 362663001253 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 362663001254 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 362663001255 dimer interface [polypeptide binding]; other site 362663001256 active site 362663001257 Schiff base residues; other site 362663001258 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 362663001259 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663001260 Autotransporter beta-domain; Region: Autotransporter; pfam03797 362663001261 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 362663001262 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 362663001263 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 362663001264 microcin B17 transporter; Reviewed; Region: PRK11098 362663001265 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 362663001266 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 362663001267 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 362663001268 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 362663001269 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 362663001270 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 362663001271 anti-RssB factor; Provisional; Region: PRK10244 362663001272 alkaline phosphatase; Provisional; Region: PRK10518 362663001273 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 362663001274 dimer interface [polypeptide binding]; other site 362663001275 active site 362663001276 hypothetical protein; Provisional; Region: PRK11505 362663001277 psiF repeat; Region: PsiF_repeat; pfam07769 362663001278 psiF repeat; Region: PsiF_repeat; pfam07769 362663001279 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 362663001280 MASE2 domain; Region: MASE2; pfam05230 362663001281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663001282 metal binding site [ion binding]; metal-binding site 362663001283 active site 362663001284 I-site; other site 362663001285 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 362663001286 pyrroline-5-carboxylate reductase; Region: PLN02688 362663001287 hypothetical protein; Validated; Region: PRK00124 362663001288 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 362663001289 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 362663001290 ADP binding site [chemical binding]; other site 362663001291 magnesium binding site [ion binding]; other site 362663001292 putative shikimate binding site; other site 362663001293 hypothetical protein; Provisional; Region: PRK10380 362663001294 hypothetical protein; Provisional; Region: PRK10481 362663001295 hypothetical protein; Provisional; Region: PRK10579 362663001296 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 362663001297 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 362663001298 fructokinase; Reviewed; Region: PRK09557 362663001299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663001300 nucleotide binding site [chemical binding]; other site 362663001301 MFS transport protein AraJ; Provisional; Region: PRK10091 362663001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001303 putative substrate translocation pore; other site 362663001304 exonuclease subunit SbcC; Provisional; Region: PRK10246 362663001305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663001306 Walker A/P-loop; other site 362663001307 ATP binding site [chemical binding]; other site 362663001308 Q-loop/lid; other site 362663001309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663001310 ABC transporter signature motif; other site 362663001311 Walker B; other site 362663001312 D-loop; other site 362663001313 H-loop/switch region; other site 362663001314 exonuclease subunit SbcD; Provisional; Region: PRK10966 362663001315 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 362663001316 active site 362663001317 metal binding site [ion binding]; metal-binding site 362663001318 DNA binding site [nucleotide binding] 362663001319 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 362663001320 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 362663001321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663001322 active site 362663001323 phosphorylation site [posttranslational modification] 362663001324 intermolecular recognition site; other site 362663001325 dimerization interface [polypeptide binding]; other site 362663001326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663001327 DNA binding site [nucleotide binding] 362663001328 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 362663001329 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 362663001330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663001331 putative active site [active] 362663001332 heme pocket [chemical binding]; other site 362663001333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663001334 dimer interface [polypeptide binding]; other site 362663001335 phosphorylation site [posttranslational modification] 362663001336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663001337 ATP binding site [chemical binding]; other site 362663001338 Mg2+ binding site [ion binding]; other site 362663001339 G-X-G motif; other site 362663001340 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 362663001341 putative proline-specific permease; Provisional; Region: proY; PRK10580 362663001342 Spore germination protein; Region: Spore_permease; cl17796 362663001343 maltodextrin glucosidase; Provisional; Region: PRK10785 362663001344 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 362663001345 homodimer interface [polypeptide binding]; other site 362663001346 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 362663001347 active site 362663001348 homodimer interface [polypeptide binding]; other site 362663001349 catalytic site [active] 362663001350 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 362663001351 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 362663001352 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 362663001353 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 362663001354 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 362663001355 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 362663001356 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 362663001357 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 362663001358 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 362663001359 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 362663001360 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 362663001361 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 362663001362 Protein export membrane protein; Region: SecD_SecF; pfam02355 362663001363 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 362663001364 active site 362663001365 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 362663001366 hypothetical protein; Provisional; Region: PRK11530 362663001367 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 362663001368 ATP cone domain; Region: ATP-cone; pfam03477 362663001369 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 362663001370 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 362663001371 catalytic motif [active] 362663001372 Zn binding site [ion binding]; other site 362663001373 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 362663001374 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 362663001375 homopentamer interface [polypeptide binding]; other site 362663001376 active site 362663001377 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 362663001378 putative RNA binding site [nucleotide binding]; other site 362663001379 thiamine monophosphate kinase; Provisional; Region: PRK05731 362663001380 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 362663001381 ATP binding site [chemical binding]; other site 362663001382 dimerization interface [polypeptide binding]; other site 362663001383 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 362663001384 tetramer interfaces [polypeptide binding]; other site 362663001385 binuclear metal-binding site [ion binding]; other site 362663001386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663001387 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663001388 active site 362663001389 catalytic tetrad [active] 362663001390 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 362663001391 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 362663001392 TPP-binding site; other site 362663001393 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362663001394 PYR/PP interface [polypeptide binding]; other site 362663001395 dimer interface [polypeptide binding]; other site 362663001396 TPP binding site [chemical binding]; other site 362663001397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362663001398 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 362663001399 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 362663001400 substrate binding pocket [chemical binding]; other site 362663001401 chain length determination region; other site 362663001402 substrate-Mg2+ binding site; other site 362663001403 catalytic residues [active] 362663001404 aspartate-rich region 1; other site 362663001405 active site lid residues [active] 362663001406 aspartate-rich region 2; other site 362663001407 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 362663001408 thiamine biosynthesis protein ThiI 362663001409 thiamine biosynthesis protein ThiI 362663001410 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 362663001411 conserved cys residue [active] 362663001412 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 362663001413 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 362663001414 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 362663001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 362663001416 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 362663001417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663001419 putative substrate translocation pore; other site 362663001420 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 362663001421 UbiA prenyltransferase family; Region: UbiA; pfam01040 362663001422 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 362663001423 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 362663001424 Subunit I/III interface [polypeptide binding]; other site 362663001425 Subunit III/IV interface [polypeptide binding]; other site 362663001426 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 362663001427 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 362663001428 D-pathway; other site 362663001429 Putative ubiquinol binding site [chemical binding]; other site 362663001430 Low-spin heme (heme b) binding site [chemical binding]; other site 362663001431 Putative water exit pathway; other site 362663001432 Binuclear center (heme o3/CuB) [ion binding]; other site 362663001433 K-pathway; other site 362663001434 Putative proton exit pathway; other site 362663001435 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 362663001436 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 362663001437 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 362663001438 muropeptide transporter; Reviewed; Region: ampG; PRK11902 362663001439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001440 putative substrate translocation pore; other site 362663001441 hypothetical protein; Provisional; Region: PRK11627 362663001442 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 362663001443 transcriptional regulator BolA; Provisional; Region: PRK11628 362663001444 trigger factor; Provisional; Region: tig; PRK01490 362663001445 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362663001446 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 362663001447 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 362663001448 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 362663001449 oligomer interface [polypeptide binding]; other site 362663001450 active site residues [active] 362663001451 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 362663001452 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 362663001453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663001454 Walker A motif; other site 362663001455 ATP binding site [chemical binding]; other site 362663001456 Walker B motif; other site 362663001457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362663001458 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 362663001459 Found in ATP-dependent protease La (LON); Region: LON; smart00464 362663001460 Found in ATP-dependent protease La (LON); Region: LON; smart00464 362663001461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663001462 Walker A motif; other site 362663001463 ATP binding site [chemical binding]; other site 362663001464 Walker B motif; other site 362663001465 arginine finger; other site 362663001466 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 362663001467 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 362663001468 IHF dimer interface [polypeptide binding]; other site 362663001469 IHF - DNA interface [nucleotide binding]; other site 362663001470 periplasmic folding chaperone; Provisional; Region: PRK10788 362663001471 SurA N-terminal domain; Region: SurA_N_3; cl07813 362663001472 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 362663001473 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 362663001474 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 362663001475 active site 362663001476 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 362663001477 Ligand Binding Site [chemical binding]; other site 362663001478 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 362663001479 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 362663001480 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 362663001481 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 362663001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663001483 active site 362663001484 motif I; other site 362663001485 motif II; other site 362663001486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663001487 dimerization interface [polypeptide binding]; other site 362663001488 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 362663001489 putative DNA binding site [nucleotide binding]; other site 362663001490 putative Zn2+ binding site [ion binding]; other site 362663001491 AsnC family; Region: AsnC_trans_reg; pfam01037 362663001492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663001493 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 362663001494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663001495 Walker A/P-loop; other site 362663001496 ATP binding site [chemical binding]; other site 362663001497 Q-loop/lid; other site 362663001498 ABC transporter signature motif; other site 362663001499 Walker B; other site 362663001500 D-loop; other site 362663001501 H-loop/switch region; other site 362663001502 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 362663001503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663001504 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 362663001505 Walker A/P-loop; other site 362663001506 ATP binding site [chemical binding]; other site 362663001507 Q-loop/lid; other site 362663001508 ABC transporter signature motif; other site 362663001509 Walker B; other site 362663001510 D-loop; other site 362663001511 H-loop/switch region; other site 362663001512 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 362663001513 Nitrogen regulatory protein P-II; Region: P-II; smart00938 362663001514 ammonium transporter; Provisional; Region: PRK10666 362663001515 acyl-CoA thioesterase II; Provisional; Region: PRK10526 362663001516 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 362663001517 active site 362663001518 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 362663001519 catalytic triad [active] 362663001520 dimer interface [polypeptide binding]; other site 362663001521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 362663001522 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 362663001523 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 362663001524 DNA binding site [nucleotide binding] 362663001525 active site 362663001526 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 362663001527 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 362663001528 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 362663001529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663001530 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 362663001531 maltose O-acetyltransferase; Provisional; Region: PRK10092 362663001532 Maltose acetyltransferase; Region: Mac; pfam12464 362663001533 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 362663001534 trimer interface [polypeptide binding]; other site 362663001535 active site 362663001536 substrate binding site [chemical binding]; other site 362663001537 CoA binding site [chemical binding]; other site 362663001538 gene expression modulator; Provisional; Region: PRK10945 362663001539 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 362663001540 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 362663001541 Protein export membrane protein; Region: SecD_SecF; cl14618 362663001542 Protein export membrane protein; Region: SecD_SecF; cl14618 362663001543 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 362663001544 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663001545 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 362663001546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663001547 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 362663001548 hypothetical protein; Provisional; Region: PRK11281 362663001549 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 362663001550 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 362663001551 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663001552 hypothetical protein; Provisional; Region: PRK11038 362663001553 primosomal replication protein N''; Provisional; Region: PRK10093 362663001554 hypothetical protein; Provisional; Region: PRK10527 362663001555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663001556 active site 362663001557 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 362663001558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663001559 Walker A motif; other site 362663001560 ATP binding site [chemical binding]; other site 362663001561 Walker B motif; other site 362663001562 DNA polymerase III subunit delta'; Validated; Region: PRK08485 362663001563 arginine finger; other site 362663001564 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 362663001565 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 362663001566 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 362663001567 hypothetical protein; Validated; Region: PRK00153 362663001568 recombination protein RecR; Reviewed; Region: recR; PRK00076 362663001569 RecR protein; Region: RecR; pfam02132 362663001570 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 362663001571 putative active site [active] 362663001572 putative metal-binding site [ion binding]; other site 362663001573 tetramer interface [polypeptide binding]; other site 362663001574 heat shock protein 90; Provisional; Region: PRK05218 362663001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663001576 ATP binding site [chemical binding]; other site 362663001577 Mg2+ binding site [ion binding]; other site 362663001578 G-X-G motif; other site 362663001579 adenylate kinase; Reviewed; Region: adk; PRK00279 362663001580 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 362663001581 AMP-binding site [chemical binding]; other site 362663001582 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 362663001583 ferrochelatase; Region: hemH; TIGR00109 362663001584 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 362663001585 C-terminal domain interface [polypeptide binding]; other site 362663001586 active site 362663001587 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 362663001588 active site 362663001589 N-terminal domain interface [polypeptide binding]; other site 362663001590 acetyl esterase; Provisional; Region: PRK10162 362663001591 inosine/guanosine kinase; Provisional; Region: PRK15074 362663001592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663001593 putative cation:proton antiport protein; Provisional; Region: PRK10669 362663001594 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 362663001595 TrkA-N domain; Region: TrkA_N; pfam02254 362663001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663001598 putative substrate translocation pore; other site 362663001599 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 362663001600 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 362663001601 active site 362663001602 metal binding site [ion binding]; metal-binding site 362663001603 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 362663001604 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 362663001605 putative deacylase active site [active] 362663001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 362663001607 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 362663001608 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 362663001609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663001610 non-specific DNA binding site [nucleotide binding]; other site 362663001611 salt bridge; other site 362663001612 sequence-specific DNA binding site [nucleotide binding]; other site 362663001613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663001614 motif II; other site 362663001615 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 362663001616 metal-binding site [ion binding] 362663001617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 362663001618 metal-binding site [ion binding] 362663001619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362663001620 glutaminase; Reviewed; Region: PRK12356 362663001621 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 362663001622 amino acid transporter; Region: 2A0306; TIGR00909 362663001623 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 362663001624 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 362663001625 DNA binding residues [nucleotide binding] 362663001626 dimer interface [polypeptide binding]; other site 362663001627 copper binding site [ion binding]; other site 362663001628 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 362663001629 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 362663001630 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 362663001631 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 362663001632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663001633 Walker A/P-loop; other site 362663001634 ATP binding site [chemical binding]; other site 362663001635 Q-loop/lid; other site 362663001636 ABC transporter signature motif; other site 362663001637 Walker B; other site 362663001638 D-loop; other site 362663001639 H-loop/switch region; other site 362663001640 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 362663001641 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 362663001642 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 362663001643 oxidoreductase; Provisional; Region: PRK08017 362663001644 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 362663001645 NADP binding site [chemical binding]; other site 362663001646 active site 362663001647 steroid binding site; other site 362663001648 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 362663001649 active site 362663001650 catalytic triad [active] 362663001651 oxyanion hole [active] 362663001652 switch loop; other site 362663001653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663001654 Walker A/P-loop; other site 362663001655 ATP binding site [chemical binding]; other site 362663001656 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362663001657 Q-loop/lid; other site 362663001658 ABC transporter signature motif; other site 362663001659 Walker B; other site 362663001660 D-loop; other site 362663001661 H-loop/switch region; other site 362663001662 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 362663001663 FtsX-like permease family; Region: FtsX; pfam02687 362663001664 FtsX-like permease family; Region: FtsX; pfam02687 362663001665 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 362663001666 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 362663001667 active site residue [active] 362663001668 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 362663001669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663001670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663001671 dimerization interface [polypeptide binding]; other site 362663001672 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 362663001673 ureidoglycolate hydrolase; Provisional; Region: PRK03606 362663001674 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 362663001675 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 362663001676 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663001677 glyoxylate carboligase; Provisional; Region: PRK11269 362663001678 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362663001679 PYR/PP interface [polypeptide binding]; other site 362663001680 dimer interface [polypeptide binding]; other site 362663001681 TPP binding site [chemical binding]; other site 362663001682 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663001683 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 362663001684 TPP-binding site [chemical binding]; other site 362663001685 hydroxypyruvate isomerase; Provisional; Region: PRK09997 362663001686 tartronate semialdehyde reductase; Provisional; Region: PRK15059 362663001687 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 362663001688 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 362663001689 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 362663001690 Na binding site [ion binding]; other site 362663001691 substrate binding site [chemical binding]; other site 362663001692 allantoinase; Provisional; Region: PRK08044 362663001693 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 362663001694 active site 362663001695 putative uracil/xanthine transporter; Provisional; Region: PRK11412 362663001696 glycerate kinase II; Provisional; Region: PRK09932 362663001697 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 362663001698 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 362663001699 Cupin domain; Region: Cupin_2; cl17218 362663001700 allantoate amidohydrolase; Region: AllC; TIGR03176 362663001701 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 362663001702 active site 362663001703 metal binding site [ion binding]; metal-binding site 362663001704 dimer interface [polypeptide binding]; other site 362663001705 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 362663001706 membrane protein FdrA; Validated; Region: PRK06091 362663001707 CoA binding domain; Region: CoA_binding; pfam02629 362663001708 CoA-ligase; Region: Ligase_CoA; pfam00549 362663001709 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 362663001710 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 362663001711 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 362663001712 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 362663001713 putative substrate binding site [chemical binding]; other site 362663001714 nucleotide binding site [chemical binding]; other site 362663001715 nucleotide binding site [chemical binding]; other site 362663001716 homodimer interface [polypeptide binding]; other site 362663001717 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 362663001718 ATP-grasp domain; Region: ATP-grasp; pfam02222 362663001719 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 362663001720 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 362663001721 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 362663001722 putative active site [active] 362663001723 putative metal binding site [ion binding]; other site 362663001724 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 362663001725 substrate binding site [chemical binding]; other site 362663001726 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 362663001727 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 362663001728 active site 362663001729 HIGH motif; other site 362663001730 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 362663001731 KMSKS motif; other site 362663001732 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 362663001733 tRNA binding surface [nucleotide binding]; other site 362663001734 anticodon binding site; other site 362663001735 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 362663001736 ribosome-associated protein; Provisional; Region: PRK11507 362663001737 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 362663001738 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 362663001739 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 362663001740 homodimer interface [polypeptide binding]; other site 362663001741 NADP binding site [chemical binding]; other site 362663001742 substrate binding site [chemical binding]; other site 362663001743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663001744 DNA binding site [nucleotide binding] 362663001745 active site 362663001746 Int/Topo IB signature motif; other site 362663001747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663001748 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 362663001749 Methyltransferase domain; Region: Methyltransf_12; pfam08242 362663001750 S-adenosylmethionine binding site [chemical binding]; other site 362663001751 outer membrane protease; Reviewed; Region: PRK10993 362663001752 hypothetical protein; Provisional; Region: PRK09936 362663001753 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 362663001754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663001755 TPR motif; other site 362663001756 binding surface 362663001757 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 362663001758 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 362663001759 active site 362663001760 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 362663001761 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 362663001762 sensor kinase CusS; Provisional; Region: PRK09835 362663001763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663001764 dimerization interface [polypeptide binding]; other site 362663001765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663001766 dimer interface [polypeptide binding]; other site 362663001767 phosphorylation site [posttranslational modification] 362663001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663001769 ATP binding site [chemical binding]; other site 362663001770 Mg2+ binding site [ion binding]; other site 362663001771 G-X-G motif; other site 362663001772 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 362663001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663001774 active site 362663001775 phosphorylation site [posttranslational modification] 362663001776 intermolecular recognition site; other site 362663001777 dimerization interface [polypeptide binding]; other site 362663001778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663001779 DNA binding site [nucleotide binding] 362663001780 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 362663001781 periplasmic copper-binding protein; Provisional; Region: PRK09838 362663001782 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 362663001783 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663001784 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 362663001785 phenylalanine transporter; Provisional; Region: PRK10249 362663001786 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 362663001787 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663001788 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 362663001789 dimer interface [polypeptide binding]; other site 362663001790 FMN binding site [chemical binding]; other site 362663001791 hypothetical protein; Provisional; Region: PRK10250 362663001792 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 362663001793 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 362663001794 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 362663001795 Hok/gef family; Region: HOK_GEF; pfam01848 362663001796 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 362663001797 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 362663001798 outer membrane receptor FepA; Provisional; Region: PRK13524 362663001799 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663001800 N-terminal plug; other site 362663001801 ligand-binding site [chemical binding]; other site 362663001802 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 362663001803 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 362663001804 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 362663001805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 362663001806 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 362663001807 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 362663001808 acyl-activating enzyme (AAE) consensus motif; other site 362663001809 AMP binding site [chemical binding]; other site 362663001810 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663001811 LPS O-antigen length regulator; Provisional; Region: PRK10381 362663001812 Chain length determinant protein; Region: Wzz; pfam02706 362663001813 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 362663001814 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 362663001815 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663001816 Walker A/P-loop; other site 362663001817 ATP binding site [chemical binding]; other site 362663001818 Q-loop/lid; other site 362663001819 ABC transporter signature motif; other site 362663001820 Walker B; other site 362663001821 D-loop; other site 362663001822 H-loop/switch region; other site 362663001823 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 362663001824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663001825 ABC-ATPase subunit interface; other site 362663001826 dimer interface [polypeptide binding]; other site 362663001827 putative PBP binding regions; other site 362663001828 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663001829 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663001830 ABC-ATPase subunit interface; other site 362663001831 dimer interface [polypeptide binding]; other site 362663001832 putative PBP binding regions; other site 362663001833 enterobactin exporter EntS; Provisional; Region: PRK10489 362663001834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663001835 putative substrate translocation pore; other site 362663001836 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 362663001837 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 362663001838 siderophore binding site; other site 362663001839 isochorismate synthase EntC; Provisional; Region: PRK15016 362663001840 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 362663001841 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 362663001842 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 362663001843 acyl-activating enzyme (AAE) consensus motif; other site 362663001844 active site 362663001845 AMP binding site [chemical binding]; other site 362663001846 substrate binding site [chemical binding]; other site 362663001847 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 362663001848 hydrophobic substrate binding pocket; other site 362663001849 Isochorismatase family; Region: Isochorismatase; pfam00857 362663001850 active site 362663001851 conserved cis-peptide bond; other site 362663001852 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 362663001853 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 362663001854 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 362663001855 putative NAD(P) binding site [chemical binding]; other site 362663001856 active site 362663001857 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 362663001858 CoenzymeA binding site [chemical binding]; other site 362663001859 subunit interaction site [polypeptide binding]; other site 362663001860 PHB binding site; other site 362663001861 carbon starvation protein A; Provisional; Region: PRK15015 362663001862 Carbon starvation protein CstA; Region: CstA; pfam02554 362663001863 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 362663001864 Uncharacterized small protein [Function unknown]; Region: COG2879 362663001865 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 362663001866 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 362663001867 putative active site [active] 362663001868 metal binding site [ion binding]; metal-binding site 362663001869 methionine aminotransferase; Validated; Region: PRK09082 362663001870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663001871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663001872 homodimer interface [polypeptide binding]; other site 362663001873 catalytic residue [active] 362663001874 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 362663001875 ParB-like nuclease domain; Region: ParBc; pfam02195 362663001876 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 362663001877 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 362663001878 Active Sites [active] 362663001879 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 362663001880 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 362663001881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663001882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663001883 dimerization interface [polypeptide binding]; other site 362663001884 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 362663001885 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 362663001886 dimerization domain [polypeptide binding]; other site 362663001887 dimer interface [polypeptide binding]; other site 362663001888 catalytic residues [active] 362663001889 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 362663001890 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 362663001891 dimer interface [polypeptide binding]; other site 362663001892 decamer (pentamer of dimers) interface [polypeptide binding]; other site 362663001893 catalytic triad [active] 362663001894 peroxidatic and resolving cysteines [active] 362663001895 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 362663001896 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 362663001897 catalytic residue [active] 362663001898 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 362663001899 catalytic residues [active] 362663001900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663001901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663001902 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663001903 Ligand Binding Site [chemical binding]; other site 362663001904 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 362663001905 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 362663001906 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 362663001907 B1 nucleotide binding pocket [chemical binding]; other site 362663001908 B2 nucleotide binding pocket [chemical binding]; other site 362663001909 CAS motifs; other site 362663001910 active site 362663001911 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663001912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 362663001913 transmembrane helices; other site 362663001914 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 362663001915 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 362663001916 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 362663001917 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 362663001918 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 362663001919 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 362663001920 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 362663001921 putative active site [active] 362663001922 (T/H)XGH motif; other site 362663001923 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 362663001924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663001925 putative active site [active] 362663001926 heme pocket [chemical binding]; other site 362663001927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663001928 ATP binding site [chemical binding]; other site 362663001929 Mg2+ binding site [ion binding]; other site 362663001930 G-X-G motif; other site 362663001931 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 362663001932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663001933 active site 362663001934 phosphorylation site [posttranslational modification] 362663001935 intermolecular recognition site; other site 362663001936 dimerization interface [polypeptide binding]; other site 362663001937 Transcriptional regulator; Region: CitT; pfam12431 362663001938 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 362663001939 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 362663001940 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 362663001941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663001942 DNA-binding site [nucleotide binding]; DNA binding site 362663001943 RNA-binding motif; other site 362663001944 chromosome condensation membrane protein; Provisional; Region: PRK14196 362663001945 Predicted amidohydrolase [General function prediction only]; Region: COG0388 362663001946 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 362663001947 putative active site [active] 362663001948 catalytic triad [active] 362663001949 putative dimer interface [polypeptide binding]; other site 362663001950 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 362663001951 lipoyl synthase; Provisional; Region: PRK05481 362663001952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663001953 FeS/SAM binding site; other site 362663001954 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 362663001955 lipoate-protein ligase B; Provisional; Region: PRK14342 362663001956 hypothetical protein; Provisional; Region: PRK04998 362663001957 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 362663001958 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 362663001959 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 362663001960 rare lipoprotein A; Provisional; Region: PRK10672 362663001961 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 362663001962 Sporulation related domain; Region: SPOR; pfam05036 362663001963 cell wall shape-determining protein; Provisional; Region: PRK10794 362663001964 penicillin-binding protein 2; Provisional; Region: PRK10795 362663001965 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 362663001966 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 362663001967 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 362663001968 ribosome-associated protein; Provisional; Region: PRK11538 362663001969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362663001970 catalytic core [active] 362663001971 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 362663001972 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 362663001973 active site 362663001974 (T/H)XGH motif; other site 362663001975 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 362663001976 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 362663001977 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 362663001978 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 362663001979 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 362663001980 HIGH motif; other site 362663001981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 362663001982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 362663001983 active site 362663001984 KMSKS motif; other site 362663001985 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 362663001986 tRNA binding surface [nucleotide binding]; other site 362663001987 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 362663001988 hypothetical protein; Provisional; Region: PRK11032 362663001989 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 362663001990 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 362663001991 active site 362663001992 tetramer interface [polypeptide binding]; other site 362663001993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362663001994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362663001995 Walker A/P-loop; other site 362663001996 ATP binding site [chemical binding]; other site 362663001997 Q-loop/lid; other site 362663001998 ABC transporter signature motif; other site 362663001999 Walker B; other site 362663002000 D-loop; other site 362663002001 H-loop/switch region; other site 362663002002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 362663002003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002004 dimer interface [polypeptide binding]; other site 362663002005 conserved gate region; other site 362663002006 putative PBP binding loops; other site 362663002007 ABC-ATPase subunit interface; other site 362663002008 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 362663002009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002010 dimer interface [polypeptide binding]; other site 362663002011 conserved gate region; other site 362663002012 putative PBP binding loops; other site 362663002013 ABC-ATPase subunit interface; other site 362663002014 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 362663002015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663002016 substrate binding pocket [chemical binding]; other site 362663002017 membrane-bound complex binding site; other site 362663002018 hinge residues; other site 362663002019 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 362663002020 Uncharacterized conserved protein [Function unknown]; Region: COG3391 362663002021 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 362663002022 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 362663002023 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 362663002024 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 362663002025 putative active site [active] 362663002026 catalytic triad [active] 362663002027 putative dimer interface [polypeptide binding]; other site 362663002028 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 362663002029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362663002030 Transporter associated domain; Region: CorC_HlyC; smart01091 362663002031 metal-binding heat shock protein; Provisional; Region: PRK00016 362663002032 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 362663002033 PhoH-like protein; Region: PhoH; pfam02562 362663002034 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 362663002035 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 362663002036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663002037 FeS/SAM binding site; other site 362663002038 TRAM domain; Region: TRAM; pfam01938 362663002039 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 362663002040 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 362663002041 asparagine synthetase B; Provisional; Region: asnB; PRK09431 362663002042 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 362663002043 active site 362663002044 dimer interface [polypeptide binding]; other site 362663002045 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 362663002046 Ligand Binding Site [chemical binding]; other site 362663002047 Molecular Tunnel; other site 362663002048 UMP phosphatase; Provisional; Region: PRK10444 362663002049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002050 active site 362663002051 motif I; other site 362663002052 motif II; other site 362663002053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002054 MarR family; Region: MarR; pfam01047 362663002055 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 362663002056 ROK family; Region: ROK; pfam00480 362663002057 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 362663002058 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 362663002059 active site 362663002060 dimer interface [polypeptide binding]; other site 362663002061 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 362663002062 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 362663002063 active site 362663002064 trimer interface [polypeptide binding]; other site 362663002065 allosteric site; other site 362663002066 active site lid [active] 362663002067 hexamer (dimer of trimers) interface [polypeptide binding]; other site 362663002068 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 362663002069 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663002070 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663002071 active site turn [active] 362663002072 phosphorylation site [posttranslational modification] 362663002073 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 362663002074 HPr interaction site; other site 362663002075 glycerol kinase (GK) interaction site [polypeptide binding]; other site 362663002076 active site 362663002077 phosphorylation site [posttranslational modification] 362663002078 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 362663002079 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663002080 transmembrane helices; other site 362663002081 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 362663002082 BNR repeat-like domain; Region: BNR_2; pfam13088 362663002083 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 362663002084 dihydrodipicolinate synthase; Region: dapA; TIGR00674 362663002085 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 362663002086 inhibitor site; inhibition site 362663002087 active site 362663002088 dimer interface [polypeptide binding]; other site 362663002089 catalytic residue [active] 362663002090 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 362663002091 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 362663002092 putative active site [active] 362663002093 metal binding site [ion binding]; metal-binding site 362663002094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 362663002095 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 362663002096 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 362663002097 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663002098 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663002099 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663002100 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 362663002101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 362663002102 active site 362663002103 HIGH motif; other site 362663002104 nucleotide binding site [chemical binding]; other site 362663002105 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 362663002106 KMSKS motif; other site 362663002107 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 362663002108 outer membrane porin, OprD family; Region: OprD; pfam03573 362663002109 YbfN-like lipoprotein; Region: YbfN; pfam13982 362663002110 ferric uptake regulator; Provisional; Region: fur; PRK09462 362663002111 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 362663002112 metal binding site 2 [ion binding]; metal-binding site 362663002113 putative DNA binding helix; other site 362663002114 metal binding site 1 [ion binding]; metal-binding site 362663002115 dimer interface [polypeptide binding]; other site 362663002116 structural Zn2+ binding site [ion binding]; other site 362663002117 flavodoxin FldA; Validated; Region: PRK09267 362663002118 LexA regulated protein; Provisional; Region: PRK11675 362663002119 acyl-CoA esterase; Provisional; Region: PRK10673 362663002120 PGAP1-like protein; Region: PGAP1; pfam07819 362663002121 replication initiation regulator SeqA; Provisional; Region: PRK11187 362663002122 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 362663002123 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 362663002124 active site 362663002125 substrate binding site [chemical binding]; other site 362663002126 metal binding site [ion binding]; metal-binding site 362663002127 putrescine transporter; Provisional; Region: potE; PRK10655 362663002128 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 362663002129 ornithine decarboxylase; Provisional; Region: PRK13578 362663002130 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663002131 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663002132 homodimer interface [polypeptide binding]; other site 362663002133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002134 catalytic residue [active] 362663002135 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663002136 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 362663002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663002138 active site 362663002139 phosphorylation site [posttranslational modification] 362663002140 intermolecular recognition site; other site 362663002141 dimerization interface [polypeptide binding]; other site 362663002142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663002143 DNA binding site [nucleotide binding] 362663002144 sensory kinase in two-component regulatory system nonfunction due to the frame shift 362663002145 sensory kinase in two-component regulatory system nonfunction due to the frame shift 362663002146 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 362663002147 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 362663002148 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362663002149 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 362663002150 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 362663002151 hypothetical protein; Provisional; Region: PRK10167 362663002152 Uncharacterized conserved protein [Function unknown]; Region: COG3272 362663002153 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 362663002154 DNA photolyase; Region: DNA_photolyase; pfam00875 362663002155 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 362663002156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663002157 putative substrate translocation pore; other site 362663002158 POT family; Region: PTR2; pfam00854 362663002159 Uncharacterized conserved protein [Function unknown]; Region: COG0327 362663002160 metal-binding protein; Provisional; Region: PRK10799 362663002161 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 362663002162 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 362663002163 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 362663002164 putative active site [active] 362663002165 endonuclease VIII; Provisional; Region: PRK10445 362663002166 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 362663002167 DNA binding site [nucleotide binding] 362663002168 catalytic residue [active] 362663002169 putative catalytic residues [active] 362663002170 H2TH interface [polypeptide binding]; other site 362663002171 intercalation triad [nucleotide binding]; other site 362663002172 substrate specificity determining residue; other site 362663002173 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 362663002174 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 362663002175 Putative ammonia monooxygenase; Region: AmoA; pfam05145 362663002176 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 362663002177 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 362663002178 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 362663002179 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 362663002180 dimer interface [polypeptide binding]; other site 362663002181 active site 362663002182 citrylCoA binding site [chemical binding]; other site 362663002183 NADH binding [chemical binding]; other site 362663002184 cationic pore residues; other site 362663002185 oxalacetate/citrate binding site [chemical binding]; other site 362663002186 coenzyme A binding site [chemical binding]; other site 362663002187 catalytic triad [active] 362663002188 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 362663002189 Iron-sulfur protein interface; other site 362663002190 proximal quinone binding site [chemical binding]; other site 362663002191 SdhD (CybS) interface [polypeptide binding]; other site 362663002192 proximal heme binding site [chemical binding]; other site 362663002193 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 362663002194 SdhC subunit interface [polypeptide binding]; other site 362663002195 proximal heme binding site [chemical binding]; other site 362663002196 cardiolipin binding site; other site 362663002197 Iron-sulfur protein interface; other site 362663002198 proximal quinone binding site [chemical binding]; other site 362663002199 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 362663002200 L-aspartate oxidase; Provisional; Region: PRK06175 362663002201 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 362663002202 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 362663002203 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 362663002204 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 362663002205 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 362663002206 TPP-binding site [chemical binding]; other site 362663002207 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 362663002208 dimer interface [polypeptide binding]; other site 362663002209 PYR/PP interface [polypeptide binding]; other site 362663002210 TPP binding site [chemical binding]; other site 362663002211 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 362663002212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362663002213 E3 interaction surface; other site 362663002214 lipoyl attachment site [posttranslational modification]; other site 362663002215 e3 binding domain; Region: E3_binding; pfam02817 362663002216 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 362663002217 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 362663002218 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 362663002219 CoA-ligase; Region: Ligase_CoA; pfam00549 362663002220 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 362663002221 CoA binding domain; Region: CoA_binding; smart00881 362663002222 CoA-ligase; Region: Ligase_CoA; pfam00549 362663002223 TPR repeat; Region: TPR_11; pfam13414 362663002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663002225 binding surface 362663002226 TPR motif; other site 362663002227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 362663002228 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 362663002229 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 362663002230 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 362663002231 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 362663002232 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 362663002233 hypothetical protein; Provisional; Region: PRK10588 362663002234 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 362663002235 active site 362663002236 colicin uptake protein TolQ; Provisional; Region: PRK10801 362663002237 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 362663002238 colicin uptake protein TolR; Provisional; Region: PRK11024 362663002239 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 362663002240 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 362663002241 TolA C-terminal; Region: TolA; pfam06519 362663002242 translocation protein TolB; Provisional; Region: tolB; PRK03629 362663002243 TolB amino-terminal domain; Region: TolB_N; pfam04052 362663002244 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 362663002245 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 362663002246 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 362663002247 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 362663002248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663002249 ligand binding site [chemical binding]; other site 362663002250 tol-pal system protein YbgF; Provisional; Region: PRK10803 362663002251 Tetratricopeptide repeat; Region: TPR_6; pfam13174 362663002252 Tetratricopeptide repeat; Region: TPR_6; pfam13174 362663002253 quinolinate synthetase; Provisional; Region: PRK09375 362663002254 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 362663002255 zinc transporter ZitB; Provisional; Region: PRK03557 362663002256 YbgS-like protein; Region: YbgS; pfam13985 362663002257 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 362663002258 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 362663002259 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362663002260 catalytic core [active] 362663002261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362663002262 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 362663002263 active site 362663002264 catalytic residues [active] 362663002265 galactokinase; Provisional; Region: PRK05101 362663002266 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 362663002267 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362663002268 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 362663002269 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 362663002270 dimer interface [polypeptide binding]; other site 362663002271 active site 362663002272 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 362663002273 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 362663002274 NAD binding site [chemical binding]; other site 362663002275 homodimer interface [polypeptide binding]; other site 362663002276 active site 362663002277 substrate binding site [chemical binding]; other site 362663002278 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 362663002279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 362663002280 Walker A/P-loop; other site 362663002281 ATP binding site [chemical binding]; other site 362663002282 Q-loop/lid; other site 362663002283 ABC transporter signature motif; other site 362663002284 Walker B; other site 362663002285 D-loop; other site 362663002286 H-loop/switch region; other site 362663002287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002288 Walker A/P-loop; other site 362663002289 ATP binding site [chemical binding]; other site 362663002290 Q-loop/lid; other site 362663002291 ABC transporter signature motif; other site 362663002292 Walker B; other site 362663002293 D-loop; other site 362663002294 H-loop/switch region; other site 362663002295 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 362663002296 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 362663002297 molybdenum-pterin binding domain; Region: Mop; TIGR00638 362663002298 TOBE domain; Region: TOBE; pfam03459 362663002299 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 362663002300 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 362663002301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663002302 substrate binding pocket [chemical binding]; other site 362663002303 membrane-bound complex binding site; other site 362663002304 hinge residues; other site 362663002305 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 362663002306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002307 dimer interface [polypeptide binding]; other site 362663002308 conserved gate region; other site 362663002309 putative PBP binding loops; other site 362663002310 ABC-ATPase subunit interface; other site 362663002311 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 362663002312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002313 Walker A/P-loop; other site 362663002314 ATP binding site [chemical binding]; other site 362663002315 Q-loop/lid; other site 362663002316 ABC transporter signature motif; other site 362663002317 Walker B; other site 362663002318 D-loop; other site 362663002319 H-loop/switch region; other site 362663002320 molybdenum-pterin binding domain; Region: Mop; TIGR00638 362663002321 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 362663002322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002323 motif II; other site 362663002324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002325 6-phosphogluconolactonase; Provisional; Region: PRK11028 362663002326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663002327 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 362663002328 putative dimerization interface [polypeptide binding]; other site 362663002329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663002330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663002331 PrpF protein; Region: PrpF; pfam04303 362663002332 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663002333 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 362663002334 transmembrane helices; other site 362663002335 putative hydratase; Provisional; Region: PRK11413 362663002336 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 362663002337 substrate binding site [chemical binding]; other site 362663002338 ligand binding site [chemical binding]; other site 362663002339 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 362663002340 substrate binding site [chemical binding]; other site 362663002341 acyl-CoA thioesterase; Provisional; Region: PRK10531 362663002342 putative pectinesterase; Region: PLN02432; cl01911 362663002343 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 362663002344 substrate binding site [chemical binding]; other site 362663002345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 362663002346 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 362663002347 Probable transposase; Region: OrfB_IS605; pfam01385 362663002348 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 362663002349 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 362663002350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663002351 inhibitor-cofactor binding pocket; inhibition site 362663002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002353 catalytic residue [active] 362663002354 biotin synthase; Provisional; Region: PRK15108 362663002355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663002356 FeS/SAM binding site; other site 362663002357 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 362663002358 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 362663002359 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 362663002360 substrate-cofactor binding pocket; other site 362663002361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002362 catalytic residue [active] 362663002363 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 362663002364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663002365 S-adenosylmethionine binding site [chemical binding]; other site 362663002366 AAA domain; Region: AAA_26; pfam13500 362663002367 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 362663002368 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 362663002369 ADP binding site [chemical binding]; other site 362663002370 excinuclease ABC subunit B; Provisional; Region: PRK05298 362663002371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663002372 ATP binding site [chemical binding]; other site 362663002373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663002374 nucleotide binding region [chemical binding]; other site 362663002375 ATP-binding site [chemical binding]; other site 362663002376 Ultra-violet resistance protein B; Region: UvrB; pfam12344 362663002377 UvrB/uvrC motif; Region: UVR; pfam02151 362663002378 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 362663002379 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 362663002380 putative substrate binding pocket [chemical binding]; other site 362663002381 dimer interface [polypeptide binding]; other site 362663002382 phosphate binding site [ion binding]; other site 362663002383 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 362663002384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663002385 FeS/SAM binding site; other site 362663002386 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 362663002387 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 362663002388 MPT binding site; other site 362663002389 trimer interface [polypeptide binding]; other site 362663002390 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 362663002391 trimer interface [polypeptide binding]; other site 362663002392 dimer interface [polypeptide binding]; other site 362663002393 putative active site [active] 362663002394 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 362663002395 MoaE interaction surface [polypeptide binding]; other site 362663002396 MoeB interaction surface [polypeptide binding]; other site 362663002397 thiocarboxylated glycine; other site 362663002398 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 362663002399 MoaE homodimer interface [polypeptide binding]; other site 362663002400 MoaD interaction [polypeptide binding]; other site 362663002401 active site residues [active] 362663002402 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 362663002403 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 362663002404 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 362663002405 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 362663002406 Predicted integral membrane protein [Function unknown]; Region: COG0392 362663002407 cardiolipin synthase 2; Provisional; Region: PRK11263 362663002408 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 362663002409 putative active site [active] 362663002410 catalytic site [active] 362663002411 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 362663002412 putative active site [active] 362663002413 catalytic site [active] 362663002414 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 362663002415 putative catalytic site [active] 362663002416 putative metal binding site [ion binding]; other site 362663002417 putative phosphate binding site [ion binding]; other site 362663002418 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 362663002419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362663002420 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 362663002421 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362663002422 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 362663002423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 362663002424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362663002425 Walker A/P-loop; other site 362663002426 ATP binding site [chemical binding]; other site 362663002427 Q-loop/lid; other site 362663002428 ABC transporter signature motif; other site 362663002429 Walker B; other site 362663002430 D-loop; other site 362663002431 H-loop/switch region; other site 362663002432 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 362663002433 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362663002434 Walker A/P-loop; other site 362663002435 ATP binding site [chemical binding]; other site 362663002436 Q-loop/lid; other site 362663002437 ABC transporter signature motif; other site 362663002438 Walker B; other site 362663002439 D-loop; other site 362663002440 H-loop/switch region; other site 362663002441 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 362663002442 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663002443 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663002444 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 362663002445 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 362663002446 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 362663002447 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362663002448 ATP binding site [chemical binding]; other site 362663002449 Mg++ binding site [ion binding]; other site 362663002450 motif III; other site 362663002451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663002452 nucleotide binding region [chemical binding]; other site 362663002453 ATP-binding site [chemical binding]; other site 362663002454 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 362663002455 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 362663002456 DEAD_2; Region: DEAD_2; pfam06733 362663002457 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 362663002458 glycosyl transferase family protein; Provisional; Region: PRK08136 362663002459 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 362663002460 putative dehydrogenase; Provisional; Region: PRK10098 362663002461 hypothetical protein; Provisional; Region: PRK10259 362663002462 hypothetical protein; Provisional; Region: PRK11019 362663002463 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 362663002464 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 362663002465 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663002466 N-terminal plug; other site 362663002467 ligand-binding site [chemical binding]; other site 362663002468 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663002469 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 362663002470 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 362663002471 putative mechanosensitive channel protein; Provisional; Region: PRK11465 362663002472 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663002473 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 362663002474 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362663002475 Walker A/P-loop; other site 362663002476 ATP binding site [chemical binding]; other site 362663002477 Q-loop/lid; other site 362663002478 ABC transporter signature motif; other site 362663002479 Walker B; other site 362663002480 D-loop; other site 362663002481 H-loop/switch region; other site 362663002482 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 362663002483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002484 dimer interface [polypeptide binding]; other site 362663002485 conserved gate region; other site 362663002486 putative PBP binding loops; other site 362663002487 ABC-ATPase subunit interface; other site 362663002488 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 362663002489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663002490 substrate binding pocket [chemical binding]; other site 362663002491 membrane-bound complex binding site; other site 362663002492 hinge residues; other site 362663002493 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 362663002494 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 362663002495 dimerization interface [polypeptide binding]; other site 362663002496 DPS ferroxidase diiron center [ion binding]; other site 362663002497 ion pore; other site 362663002498 threonine and homoserine efflux system; Provisional; Region: PRK10532 362663002499 EamA-like transporter family; Region: EamA; pfam00892 362663002500 outer membrane protein X; Provisional; Region: ompX; PRK09408 362663002501 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 362663002502 Sulfatase; Region: Sulfatase; pfam00884 362663002503 manganese transport regulator MntR; Provisional; Region: PRK11050 362663002504 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 362663002505 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 362663002506 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663002507 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 362663002508 transmembrane helices; other site 362663002509 L,D-transpeptidase; Provisional; Region: PRK10260 362663002510 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663002511 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 362663002512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002513 Walker A/P-loop; other site 362663002514 ATP binding site [chemical binding]; other site 362663002515 Q-loop/lid; other site 362663002516 ABC transporter signature motif; other site 362663002517 Walker B; other site 362663002518 D-loop; other site 362663002519 H-loop/switch region; other site 362663002520 ABC transporter; Region: ABC_tran_2; pfam12848 362663002521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663002522 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 362663002523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002524 active site 362663002525 motif I; other site 362663002526 motif II; other site 362663002527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002528 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 362663002529 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 362663002530 dimer interface [polypeptide binding]; other site 362663002531 active site 362663002532 glycine loop; other site 362663002533 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 362663002534 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 362663002535 active site 362663002536 intersubunit interactions; other site 362663002537 catalytic residue [active] 362663002538 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 362663002539 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 362663002540 ATP binding site [chemical binding]; other site 362663002541 substrate interface [chemical binding]; other site 362663002542 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 362663002543 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 362663002544 dimer interface [polypeptide binding]; other site 362663002545 putative functional site; other site 362663002546 putative MPT binding site; other site 362663002547 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 362663002548 catalytic nucleophile [active] 362663002549 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 362663002550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663002551 Walker A/P-loop; other site 362663002552 ATP binding site [chemical binding]; other site 362663002553 Q-loop/lid; other site 362663002554 ABC transporter signature motif; other site 362663002555 Walker B; other site 362663002556 D-loop; other site 362663002557 H-loop/switch region; other site 362663002558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362663002559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663002560 Walker A/P-loop; other site 362663002561 ATP binding site [chemical binding]; other site 362663002562 Q-loop/lid; other site 362663002563 ABC transporter signature motif; other site 362663002564 Walker B; other site 362663002565 D-loop; other site 362663002566 H-loop/switch region; other site 362663002567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 362663002568 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 362663002569 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 362663002570 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 362663002571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002572 dimer interface [polypeptide binding]; other site 362663002573 conserved gate region; other site 362663002574 putative PBP binding loops; other site 362663002575 ABC-ATPase subunit interface; other site 362663002576 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 362663002577 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362663002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002579 dimer interface [polypeptide binding]; other site 362663002580 conserved gate region; other site 362663002581 putative PBP binding loops; other site 362663002582 ABC-ATPase subunit interface; other site 362663002583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663002584 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663002585 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663002586 metal binding site [ion binding]; metal-binding site 362663002587 active site 362663002588 I-site; other site 362663002589 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 362663002590 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 362663002591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663002592 FeS/SAM binding site; other site 362663002593 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 362663002594 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 362663002595 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 362663002596 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 362663002597 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 362663002598 putative C-terminal domain interface [polypeptide binding]; other site 362663002599 putative GSH binding site (G-site) [chemical binding]; other site 362663002600 putative dimer interface [polypeptide binding]; other site 362663002601 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 362663002602 N-terminal domain interface [polypeptide binding]; other site 362663002603 dimer interface [polypeptide binding]; other site 362663002604 substrate binding pocket (H-site) [chemical binding]; other site 362663002605 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 362663002606 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 362663002607 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 362663002608 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 362663002609 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362663002610 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663002611 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 362663002612 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362663002613 active site 362663002614 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 362663002615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663002616 putative substrate translocation pore; other site 362663002617 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 362663002618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002619 active site 362663002620 motif I; other site 362663002621 motif II; other site 362663002622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663002623 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 362663002624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663002625 putative substrate translocation pore; other site 362663002626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663002627 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 362663002628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663002629 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 362663002630 putative transporter; Provisional; Region: PRK04972 362663002631 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 362663002632 TrkA-C domain; Region: TrkA_C; pfam02080 362663002633 TrkA-C domain; Region: TrkA_C; pfam02080 362663002634 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 362663002635 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 362663002636 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 362663002637 GSH binding site [chemical binding]; other site 362663002638 catalytic residues [active] 362663002639 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 362663002640 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 362663002641 dimer interface [polypeptide binding]; other site 362663002642 FMN binding site [chemical binding]; other site 362663002643 NADPH bind site [chemical binding]; other site 362663002644 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 362663002645 RimK-like ATP-grasp domain; Region: RimK; pfam08443 362663002646 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 362663002647 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 362663002648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 362663002649 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 362663002650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002651 Walker A/P-loop; other site 362663002652 ATP binding site [chemical binding]; other site 362663002653 Q-loop/lid; other site 362663002654 ABC transporter signature motif; other site 362663002655 Walker B; other site 362663002656 D-loop; other site 362663002657 H-loop/switch region; other site 362663002658 TOBE domain; Region: TOBE_2; pfam08402 362663002659 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 362663002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002661 dimer interface [polypeptide binding]; other site 362663002662 conserved gate region; other site 362663002663 putative PBP binding loops; other site 362663002664 ABC-ATPase subunit interface; other site 362663002665 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 362663002666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002667 dimer interface [polypeptide binding]; other site 362663002668 conserved gate region; other site 362663002669 putative PBP binding loops; other site 362663002670 ABC-ATPase subunit interface; other site 362663002671 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 362663002672 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 362663002673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663002674 S-adenosylmethionine binding site [chemical binding]; other site 362663002675 arginine-binding periplasmic protein nonfunction due to the frame shift 362663002676 arginine-binding periplasmic protein nonfunction due to the frame shift 362663002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002678 dimer interface [polypeptide binding]; other site 362663002679 conserved gate region; other site 362663002680 putative PBP binding loops; other site 362663002681 ABC-ATPase subunit interface; other site 362663002682 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 362663002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002684 dimer interface [polypeptide binding]; other site 362663002685 conserved gate region; other site 362663002686 putative PBP binding loops; other site 362663002687 ABC-ATPase subunit interface; other site 362663002688 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 362663002689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663002690 substrate binding pocket [chemical binding]; other site 362663002691 membrane-bound complex binding site; other site 362663002692 hinge residues; other site 362663002693 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 362663002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002695 Walker A/P-loop; other site 362663002696 ATP binding site [chemical binding]; other site 362663002697 Q-loop/lid; other site 362663002698 ABC transporter signature motif; other site 362663002699 Walker B; other site 362663002700 D-loop; other site 362663002701 H-loop/switch region; other site 362663002702 putative lipoprotein; Provisional; Region: PRK10533 362663002703 hypothetical protein; Provisional; Region: PRK02877 362663002704 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 362663002705 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 362663002706 amidase catalytic site [active] 362663002707 Zn binding residues [ion binding]; other site 362663002708 substrate binding site [chemical binding]; other site 362663002709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362663002710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362663002711 NAD(P) binding site [chemical binding]; other site 362663002712 active site 362663002713 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 362663002714 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 362663002715 putative NAD(P) binding site [chemical binding]; other site 362663002716 putative active site [active] 362663002717 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 362663002718 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 362663002719 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 362663002720 tetramer interface [polypeptide binding]; other site 362663002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002722 catalytic residue [active] 362663002723 pyruvate dehydrogenase; Provisional; Region: PRK09124 362663002724 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 362663002725 PYR/PP interface [polypeptide binding]; other site 362663002726 dimer interface [polypeptide binding]; other site 362663002727 tetramer interface [polypeptide binding]; other site 362663002728 TPP binding site [chemical binding]; other site 362663002729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663002730 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 362663002731 TPP-binding site [chemical binding]; other site 362663002732 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 362663002733 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 362663002734 FAD binding pocket [chemical binding]; other site 362663002735 FAD binding motif [chemical binding]; other site 362663002736 phosphate binding motif [ion binding]; other site 362663002737 beta-alpha-beta structure motif; other site 362663002738 NAD binding pocket [chemical binding]; other site 362663002739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663002740 catalytic loop [active] 362663002741 iron binding site [ion binding]; other site 362663002742 hybrid cluster protein; Provisional; Region: PRK05290 362663002743 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663002744 ACS interaction site; other site 362663002745 CODH interaction site; other site 362663002746 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 362663002747 hybrid metal cluster; other site 362663002748 Predicted membrane protein [Function unknown]; Region: COG2431 362663002749 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 362663002750 amphipathic channel; other site 362663002751 Asn-Pro-Ala signature motifs; other site 362663002752 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 362663002753 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 362663002754 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 362663002755 putative active site [active] 362663002756 putative metal-binding site [ion binding]; other site 362663002757 Protein of unknown function (DUF535); Region: DUF535; pfam04393 362663002758 macrolide transporter subunit MacA; Provisional; Region: PRK11578 362663002759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663002760 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663002761 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 362663002762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362663002763 Walker A/P-loop; other site 362663002764 ATP binding site [chemical binding]; other site 362663002765 Q-loop/lid; other site 362663002766 ABC transporter signature motif; other site 362663002767 Walker B; other site 362663002768 D-loop; other site 362663002769 H-loop/switch region; other site 362663002770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362663002771 FtsX-like permease family; Region: FtsX; pfam02687 362663002772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663002773 DNA-binding site [nucleotide binding]; DNA binding site 362663002774 RNA-binding motif; other site 362663002775 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 362663002776 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 362663002777 Clp amino terminal domain; Region: Clp_N; pfam02861 362663002778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663002779 Walker A motif; other site 362663002780 ATP binding site [chemical binding]; other site 362663002781 Walker B motif; other site 362663002782 arginine finger; other site 362663002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663002784 Walker A motif; other site 362663002785 ATP binding site [chemical binding]; other site 362663002786 Walker B motif; other site 362663002787 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362663002788 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 362663002789 rRNA binding site [nucleotide binding]; other site 362663002790 predicted 30S ribosome binding site; other site 362663002791 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 362663002792 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 362663002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663002794 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 362663002795 Walker A/P-loop; other site 362663002796 ATP binding site [chemical binding]; other site 362663002797 Q-loop/lid; other site 362663002798 ABC transporter signature motif; other site 362663002799 Walker B; other site 362663002800 D-loop; other site 362663002801 H-loop/switch region; other site 362663002802 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 362663002803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663002804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663002805 Walker A/P-loop; other site 362663002806 ATP binding site [chemical binding]; other site 362663002807 Q-loop/lid; other site 362663002808 ABC transporter signature motif; other site 362663002809 Walker B; other site 362663002810 D-loop; other site 362663002811 H-loop/switch region; other site 362663002812 thioredoxin reductase; Provisional; Region: PRK10262 362663002813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663002814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663002815 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 362663002816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663002817 putative DNA binding site [nucleotide binding]; other site 362663002818 putative Zn2+ binding site [ion binding]; other site 362663002819 AsnC family; Region: AsnC_trans_reg; pfam01037 362663002820 DNA translocase FtsK; Provisional; Region: PRK10263 362663002821 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 362663002822 DNA translocase FtsK; Provisional; Region: PRK10263 362663002823 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 362663002824 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 362663002825 periplasmic chaperone LolA; Region: lolA; TIGR00547 362663002826 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 362663002827 recombination factor protein RarA; Reviewed; Region: PRK13342 362663002828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663002829 Walker A motif; other site 362663002830 ATP binding site [chemical binding]; other site 362663002831 Walker B motif; other site 362663002832 arginine finger; other site 362663002833 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 362663002834 seryl-tRNA synthetase; Provisional; Region: PRK05431 362663002835 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 362663002836 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 362663002837 dimer interface [polypeptide binding]; other site 362663002838 active site 362663002839 motif 1; other site 362663002840 motif 2; other site 362663002841 motif 3; other site 362663002842 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 362663002843 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 362663002844 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 362663002845 putative [Fe4-S4] binding site [ion binding]; other site 362663002846 putative molybdopterin cofactor binding site [chemical binding]; other site 362663002847 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 362663002848 putative molybdopterin cofactor binding site; other site 362663002849 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 362663002850 4Fe-4S binding domain; Region: Fer4; pfam00037 362663002851 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 362663002852 Isochorismatase family; Region: Isochorismatase; pfam00857 362663002853 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 362663002854 catalytic triad [active] 362663002855 dimer interface [polypeptide binding]; other site 362663002856 conserved cis-peptide bond; other site 362663002857 putative MFS family transporter protein; Provisional; Region: PRK03633 362663002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663002859 putative substrate translocation pore; other site 362663002860 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 362663002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663002862 FeS/SAM binding site; other site 362663002863 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 362663002864 Pyruvate formate lyase 1; Region: PFL1; cd01678 362663002865 coenzyme A binding site [chemical binding]; other site 362663002866 active site 362663002867 catalytic residues [active] 362663002868 glycine loop; other site 362663002869 formate transporter; Provisional; Region: PRK10805 362663002870 uncharacterized domain; Region: TIGR00702 362663002871 YcaO-like family; Region: YcaO; pfam02624 362663002872 Predicted membrane protein [Function unknown]; Region: COG2323 362663002873 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 362663002874 homodimer interface [polypeptide binding]; other site 362663002875 substrate-cofactor binding pocket; other site 362663002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002877 catalytic residue [active] 362663002878 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 362663002879 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 362663002880 hinge; other site 362663002881 active site 362663002882 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 362663002883 cytidylate kinase; Provisional; Region: cmk; PRK00023 362663002884 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 362663002885 CMP-binding site; other site 362663002886 The sites determining sugar specificity; other site 362663002887 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 362663002888 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 362663002889 RNA binding site [nucleotide binding]; other site 362663002890 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 362663002891 RNA binding site [nucleotide binding]; other site 362663002892 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 362663002893 RNA binding site [nucleotide binding]; other site 362663002894 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 362663002895 RNA binding site [nucleotide binding]; other site 362663002896 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 362663002897 RNA binding site [nucleotide binding]; other site 362663002898 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 362663002899 IHF dimer interface [polypeptide binding]; other site 362663002900 IHF - DNA interface [nucleotide binding]; other site 362663002901 ComEC family competence protein; Provisional; Region: PRK11539 362663002902 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 362663002903 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 362663002904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 362663002905 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 362663002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663002907 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 362663002908 Walker A/P-loop; other site 362663002909 ATP binding site [chemical binding]; other site 362663002910 Q-loop/lid; other site 362663002911 ABC transporter signature motif; other site 362663002912 Walker B; other site 362663002913 D-loop; other site 362663002914 H-loop/switch region; other site 362663002915 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 362663002916 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 362663002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 362663002918 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 362663002919 hypothetical protein; Provisional; Region: PRK11827 362663002920 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 362663002921 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 362663002922 Ligand binding site; other site 362663002923 oligomer interface; other site 362663002924 hypothetical protein; Provisional; Region: PRK10593 362663002925 Uncharacterized conserved protein [Function unknown]; Region: COG1434 362663002926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 362663002927 putative active site [active] 362663002928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 362663002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663002930 S-adenosylmethionine binding site [chemical binding]; other site 362663002931 condesin subunit F; Provisional; Region: PRK05260 362663002932 condesin subunit E; Provisional; Region: PRK05256 362663002933 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 362663002934 MukB N-terminal; Region: MukB; pfam04310 362663002935 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 362663002936 murein L,D-transpeptidase; Provisional; Region: PRK10594 362663002937 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 362663002938 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663002939 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 362663002941 Peptidase M15; Region: Peptidase_M15_3; cl01194 362663002942 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 362663002943 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 362663002944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663002945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663002946 homodimer interface [polypeptide binding]; other site 362663002947 catalytic residue [active] 362663002948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663002949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663002950 trimer interface [polypeptide binding]; other site 362663002951 eyelet of channel; other site 362663002952 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 362663002953 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 362663002954 putative dimer interface [polypeptide binding]; other site 362663002955 putative anticodon binding site; other site 362663002956 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 362663002957 homodimer interface [polypeptide binding]; other site 362663002958 motif 1; other site 362663002959 motif 2; other site 362663002960 active site 362663002961 motif 3; other site 362663002962 nicotinate phosphoribosyltransferase 362663002963 nicotinate phosphoribosyltransferase 362663002964 aminopeptidase N; Provisional; Region: pepN; PRK14015 362663002965 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 362663002966 active site 362663002967 Zn binding site [ion binding]; other site 362663002968 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 362663002969 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 362663002970 Walker A/P-loop; other site 362663002971 ATP binding site [chemical binding]; other site 362663002972 Q-loop/lid; other site 362663002973 ABC transporter signature motif; other site 362663002974 Walker B; other site 362663002975 D-loop; other site 362663002976 H-loop/switch region; other site 362663002977 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 362663002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663002979 dimer interface [polypeptide binding]; other site 362663002980 conserved gate region; other site 362663002981 putative PBP binding loops; other site 362663002982 ABC-ATPase subunit interface; other site 362663002983 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 362663002984 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 362663002985 active site 362663002986 dimer interface [polypeptide binding]; other site 362663002987 non-prolyl cis peptide bond; other site 362663002988 insertion regions; other site 362663002989 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 362663002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663002991 substrate binding pocket [chemical binding]; other site 362663002992 membrane-bound complex binding site; other site 362663002993 hinge residues; other site 362663002994 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 362663002995 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362663002996 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 362663002997 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 362663002998 quinone interaction residues [chemical binding]; other site 362663002999 active site 362663003000 catalytic residues [active] 362663003001 FMN binding site [chemical binding]; other site 362663003002 substrate binding site [chemical binding]; other site 362663003003 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 362663003004 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 362663003005 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 362663003006 MOSC domain; Region: MOSC; pfam03473 362663003007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663003008 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 362663003009 catalytic loop [active] 362663003010 iron binding site [ion binding]; other site 362663003011 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 362663003012 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 362663003013 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 362663003014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663003015 S-adenosylmethionine binding site [chemical binding]; other site 362663003016 ABC transporter ATPase component; Reviewed; Region: PRK11147 362663003017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663003018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663003019 Walker A/P-loop; other site 362663003020 Walker A/P-loop; other site 362663003021 ATP binding site [chemical binding]; other site 362663003022 ATP binding site [chemical binding]; other site 362663003023 Q-loop/lid; other site 362663003024 Q-loop/lid; other site 362663003025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663003026 ABC transporter signature motif; other site 362663003027 Walker B; other site 362663003028 D-loop; other site 362663003029 ABC transporter; Region: ABC_tran_2; pfam12848 362663003030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663003031 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 362663003032 Paraquat-inducible protein A; Region: PqiA; pfam04403 362663003033 Paraquat-inducible protein A; Region: PqiA; pfam04403 362663003034 paraquat-inducible protein B; Provisional; Region: PRK10807 362663003035 mce related protein; Region: MCE; pfam02470 362663003036 mce related protein; Region: MCE; pfam02470 362663003037 mce related protein; Region: MCE; pfam02470 362663003038 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 362663003039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 362663003040 Protein of unknown function (DUF330); Region: DUF330; pfam03886 362663003041 ribosome modulation factor; Provisional; Region: PRK14563 362663003042 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 362663003043 active site 1 [active] 362663003044 dimer interface [polypeptide binding]; other site 362663003045 active site 2 [active] 362663003046 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 362663003047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 362663003048 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 362663003049 outer membrane protein A; Reviewed; Region: PRK10808 362663003050 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 362663003051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663003052 ligand binding site [chemical binding]; other site 362663003053 SOS cell division inhibitor; Provisional; Region: PRK10595 362663003054 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 362663003055 TfoX C-terminal domain; Region: TfoX_C; pfam04994 362663003056 TIGR01666 family membrane protein; Region: YCCS 362663003057 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 362663003058 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663003059 Predicted membrane protein [Function unknown]; Region: COG3304 362663003060 Domain of unknown function (DUF307); Region: DUF307; pfam03733 362663003061 Domain of unknown function (DUF307); Region: DUF307; pfam03733 362663003062 DNA helicase IV; Provisional; Region: helD; PRK11054 362663003063 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 362663003064 Part of AAA domain; Region: AAA_19; pfam13245 362663003065 Family description; Region: UvrD_C_2; pfam13538 362663003066 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 362663003067 active site 362663003068 dimer interfaces [polypeptide binding]; other site 362663003069 catalytic residues [active] 362663003070 hypothetical protein; Provisional; Region: PRK03641 362663003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 362663003072 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 362663003073 heat shock protein HspQ; Provisional; Region: PRK14129 362663003074 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 362663003075 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 362663003076 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 362663003077 putative RNA binding site [nucleotide binding]; other site 362663003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663003079 S-adenosylmethionine binding site [chemical binding]; other site 362663003080 Acylphosphatase; Region: Acylphosphatase; cl00551 362663003081 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 362663003082 sulfur transfer protein TusE; Provisional; Region: PRK11508 362663003083 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 362663003084 YccA-like proteins; Region: YccA_like; cd10433 362663003085 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 362663003086 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 362663003087 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 362663003088 hydrogenase 1 large subunit; Provisional; Region: PRK10170 362663003089 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 362663003090 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 362663003091 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 362663003092 putative substrate-binding site; other site 362663003093 nickel binding site [ion binding]; other site 362663003094 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 362663003095 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 362663003096 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 362663003097 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 362663003098 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 362663003099 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 362663003100 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 362663003101 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 362663003102 catalytic core [active] 362663003103 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 362663003104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663003105 DNA-binding site [nucleotide binding]; DNA binding site 362663003106 RNA-binding motif; other site 362663003107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663003108 DNA-binding site [nucleotide binding]; DNA binding site 362663003109 RNA-binding motif; other site 362663003110 GnsA/GnsB family; Region: GnsAB; pfam08178 362663003111 4Fe-4S binding domain; Region: Fer4_5; pfam12801 362663003112 4Fe-4S binding domain; Region: Fer4_5; pfam12801 362663003113 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663003114 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 362663003115 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 362663003116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 362663003117 dimerization interface [polypeptide binding]; other site 362663003118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663003119 dimer interface [polypeptide binding]; other site 362663003120 phosphorylation site [posttranslational modification] 362663003121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663003122 ATP binding site [chemical binding]; other site 362663003123 Mg2+ binding site [ion binding]; other site 362663003124 G-X-G motif; other site 362663003125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663003126 active site 362663003127 phosphorylation site [posttranslational modification] 362663003128 intermolecular recognition site; other site 362663003129 dimerization interface [polypeptide binding]; other site 362663003130 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663003131 putative binding surface; other site 362663003132 active site 362663003133 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 362663003134 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 362663003135 putative ligand binding site [chemical binding]; other site 362663003136 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 362663003137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663003138 active site 362663003139 phosphorylation site [posttranslational modification] 362663003140 intermolecular recognition site; other site 362663003141 dimerization interface [polypeptide binding]; other site 362663003142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663003143 DNA binding site [nucleotide binding] 362663003144 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 362663003145 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 362663003146 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 362663003147 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 362663003148 molybdopterin cofactor binding site [chemical binding]; other site 362663003149 substrate binding site [chemical binding]; other site 362663003150 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 362663003151 molybdopterin cofactor binding site; other site 362663003152 chaperone protein TorD; Validated; Region: torD; PRK04976 362663003153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663003154 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663003155 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663003156 Integrase core domain; Region: rve; pfam00665 362663003157 Integrase core domain; Region: rve_2; pfam13333 362663003158 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 362663003159 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 362663003160 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 362663003161 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 362663003162 HSP70 interaction site [polypeptide binding]; other site 362663003163 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 362663003164 substrate binding site [polypeptide binding]; other site 362663003165 dimer interface [polypeptide binding]; other site 362663003166 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 362663003167 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 362663003168 catalytic core [active] 362663003169 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 362663003170 hypothetical protein; Provisional; Region: PRK10174 362663003171 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 362663003172 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362663003173 General stress protein [General function prediction only]; Region: GsiB; COG3729 362663003174 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 362663003175 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 362663003176 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 362663003177 putative FMN binding site [chemical binding]; other site 362663003178 pyrimidine utilization protein D; Region: RutD; TIGR03611 362663003179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 362663003180 homotrimer interaction site [polypeptide binding]; other site 362663003181 putative active site [active] 362663003182 Isochorismatase family; Region: Isochorismatase; pfam00857 362663003183 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 362663003184 catalytic triad [active] 362663003185 conserved cis-peptide bond; other site 362663003186 pyrimidine utilization protein A; Region: RutA; TIGR03612 362663003187 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 362663003188 active site 362663003189 dimer interface [polypeptide binding]; other site 362663003190 non-prolyl cis peptide bond; other site 362663003191 insertion regions; other site 362663003192 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 362663003193 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 362663003194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663003195 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 362663003196 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 362663003197 Predicted transcriptional regulator [Transcription]; Region: COG3905 362663003198 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 362663003199 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 362663003200 Glutamate binding site [chemical binding]; other site 362663003201 NAD binding site [chemical binding]; other site 362663003202 catalytic residues [active] 362663003203 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 362663003204 Na binding site [ion binding]; other site 362663003205 FTR1 family protein; Region: TIGR00145 362663003206 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 362663003207 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 362663003208 Imelysin; Region: Peptidase_M75; pfam09375 362663003209 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 362663003210 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 362663003211 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 362663003212 hypothetical protein; Provisional; Region: PRK10536 362663003213 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 362663003214 N-glycosyltransferase; Provisional; Region: PRK11204 362663003215 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 362663003216 DXD motif; other site 362663003217 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 362663003218 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 362663003219 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 362663003220 putative active site [active] 362663003221 putative metal binding site [ion binding]; other site 362663003222 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 362663003223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663003224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663003225 metal binding site [ion binding]; metal-binding site 362663003226 active site 362663003227 I-site; other site 362663003228 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 362663003229 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 362663003230 putative ligand binding site [chemical binding]; other site 362663003231 NAD binding site [chemical binding]; other site 362663003232 dimerization interface [polypeptide binding]; other site 362663003233 catalytic site [active] 362663003234 putative hydrolase; Validated; Region: PRK09248 362663003235 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 362663003236 active site 362663003237 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 362663003238 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 362663003239 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 362663003240 curli assembly protein CsgF; Provisional; Region: PRK10050 362663003241 curli assembly protein CsgE; Provisional; Region: PRK10386 362663003242 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 362663003243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663003244 DNA binding residues [nucleotide binding] 362663003245 dimerization interface [polypeptide binding]; other site 362663003246 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 362663003247 Curlin associated repeat; Region: Curlin_rpt; pfam07012 362663003248 Curlin associated repeat; Region: Curlin_rpt; pfam07012 362663003249 major curlin subunit; Provisional; Region: csgA; PRK10051 362663003250 Curlin associated repeat; Region: Curlin_rpt; pfam07012 362663003251 Curlin associated repeat; Region: Curlin_rpt; pfam07012 362663003252 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 362663003253 Fimbrial protein; Region: Fimbrial; cl01416 362663003254 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 362663003255 putative ADP-ribose binding site [chemical binding]; other site 362663003256 putative active site [active] 362663003257 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 362663003258 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 362663003259 putative active site [active] 362663003260 catalytic site [active] 362663003261 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 362663003262 putative active site [active] 362663003263 catalytic site [active] 362663003264 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 362663003265 Acyltransferase family; Region: Acyl_transf_3; pfam01757 362663003266 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 362663003267 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 362663003268 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 362663003269 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 362663003270 Ligand binding site; other site 362663003271 DXD motif; other site 362663003272 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 362663003273 lipoprotein; Provisional; Region: PRK10175 362663003274 secY/secA suppressor protein; Provisional; Region: PRK11467 362663003275 drug efflux system protein MdtG; Provisional; Region: PRK09874 362663003276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663003277 putative substrate translocation pore; other site 362663003278 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 362663003279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 362663003280 putative acyl-acceptor binding pocket; other site 362663003281 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 362663003282 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 362663003283 active site residue [active] 362663003284 hypothetical protein; Provisional; Region: PRK03757 362663003285 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 362663003286 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 362663003287 hydroxyglutarate oxidase; Provisional; Region: PRK11728 362663003288 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 362663003289 DNA damage-inducible protein I; Provisional; Region: PRK10597 362663003290 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 362663003291 active site 362663003292 substrate binding pocket [chemical binding]; other site 362663003293 dimer interface [polypeptide binding]; other site 362663003294 lipoprotein; Provisional; Region: PRK10598 362663003295 glutaredoxin 2; Provisional; Region: PRK10387 362663003296 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 362663003297 C-terminal domain interface [polypeptide binding]; other site 362663003298 GSH binding site (G-site) [chemical binding]; other site 362663003299 catalytic residues [active] 362663003300 putative dimer interface [polypeptide binding]; other site 362663003301 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 362663003302 N-terminal domain interface [polypeptide binding]; other site 362663003303 multidrug resistance protein MdtH; Provisional; Region: PRK11646 362663003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663003305 putative substrate translocation pore; other site 362663003306 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 362663003307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 362663003308 hypothetical protein; Provisional; Region: PRK11239 362663003309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 362663003310 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362663003311 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663003312 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362663003313 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 362663003314 MviN-like protein; Region: MVIN; pfam03023 362663003315 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 362663003316 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 362663003317 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 362663003318 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 362663003319 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 362663003320 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 362663003321 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 362663003322 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 362663003323 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 362663003324 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 362663003325 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 362663003326 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 362663003327 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 362663003328 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 362663003329 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 362663003330 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 362663003331 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 362663003332 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 362663003333 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 362663003334 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 362663003335 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 362663003336 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 362663003337 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 362663003338 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 362663003339 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 362663003340 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 362663003341 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 362663003342 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 362663003343 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 362663003344 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 362663003345 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 362663003346 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 362663003347 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 362663003348 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 362663003349 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 362663003350 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 362663003351 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 362663003352 homodimer interface [polypeptide binding]; other site 362663003353 oligonucleotide binding site [chemical binding]; other site 362663003354 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 362663003355 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 362663003356 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 362663003357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663003358 RNA binding surface [nucleotide binding]; other site 362663003359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362663003360 active site 362663003361 Maf-like protein; Region: Maf; pfam02545 362663003362 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 362663003363 active site 362663003364 dimer interface [polypeptide binding]; other site 362663003365 hypothetical protein; Provisional; Region: PRK11193 362663003366 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 362663003367 putative phosphate acyltransferase; Provisional; Region: PRK05331 362663003368 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 362663003369 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 362663003370 dimer interface [polypeptide binding]; other site 362663003371 active site 362663003372 CoA binding pocket [chemical binding]; other site 362663003373 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 362663003374 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 362663003375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 362663003376 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 362663003377 NAD(P) binding site [chemical binding]; other site 362663003378 homotetramer interface [polypeptide binding]; other site 362663003379 homodimer interface [polypeptide binding]; other site 362663003380 active site 362663003381 acyl carrier protein; Provisional; Region: acpP; PRK00982 362663003382 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 362663003383 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 362663003384 dimer interface [polypeptide binding]; other site 362663003385 active site 362663003386 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 362663003387 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 362663003388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663003389 catalytic residue [active] 362663003390 conserved hypothetical protein, YceG family; Region: TIGR00247 362663003391 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 362663003392 dimerization interface [polypeptide binding]; other site 362663003393 thymidylate kinase; Validated; Region: tmk; PRK00698 362663003394 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 362663003395 TMP-binding site; other site 362663003396 ATP-binding site [chemical binding]; other site 362663003397 DNA polymerase III subunit delta'; Validated; Region: PRK07993 362663003398 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 362663003399 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 362663003400 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 362663003401 active site 362663003402 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 362663003403 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663003404 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663003405 active site turn [active] 362663003406 phosphorylation site [posttranslational modification] 362663003407 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 362663003408 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663003409 N-terminal plug; other site 362663003410 ligand-binding site [chemical binding]; other site 362663003411 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 362663003412 nucleotide binding site/active site [active] 362663003413 HIT family signature motif; other site 362663003414 catalytic residue [active] 362663003415 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 362663003416 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 362663003417 putative dimer interface [polypeptide binding]; other site 362663003418 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 362663003419 thiamine kinase; Region: ycfN_thiK; TIGR02721 362663003420 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 362663003421 active site 362663003422 substrate binding site [chemical binding]; other site 362663003423 ATP binding site [chemical binding]; other site 362663003424 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 362663003425 beta-hexosaminidase; Provisional; Region: PRK05337 362663003426 hypothetical protein; Provisional; Region: PRK04940 362663003427 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 362663003428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663003429 hypothetical protein; Provisional; Region: PRK11280 362663003430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663003431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663003432 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663003433 L,D-transpeptidase; Provisional; Region: PRK10260 362663003434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663003435 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663003436 transcription-repair coupling factor; Provisional; Region: PRK10689 362663003437 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 362663003438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663003439 ATP binding site [chemical binding]; other site 362663003440 putative Mg++ binding site [ion binding]; other site 362663003441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663003442 nucleotide binding region [chemical binding]; other site 362663003443 ATP-binding site [chemical binding]; other site 362663003444 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 362663003445 Predicted membrane protein [Function unknown]; Region: COG4763 362663003446 Predicted membrane protein [Function unknown]; Region: COG4763 362663003447 Acyltransferase family; Region: Acyl_transf_3; pfam01757 362663003448 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 362663003449 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 362663003450 FtsX-like permease family; Region: FtsX; pfam02687 362663003451 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 362663003452 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362663003453 Walker A/P-loop; other site 362663003454 ATP binding site [chemical binding]; other site 362663003455 Q-loop/lid; other site 362663003456 ABC transporter signature motif; other site 362663003457 Walker B; other site 362663003458 D-loop; other site 362663003459 H-loop/switch region; other site 362663003460 lipoprotein releasing system transmembrane protein LolE nonfunction due to the frame shift 362663003461 lipoprotein releasing system transmembrane protein LolE nonfunction due to the frame shift 362663003462 fructokinase; Reviewed; Region: PRK09557 362663003463 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663003464 nucleotide binding site [chemical binding]; other site 362663003465 NAD-dependent deacetylase; Provisional; Region: PRK00481 362663003466 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 362663003467 NAD+ binding site [chemical binding]; other site 362663003468 substrate binding site [chemical binding]; other site 362663003469 Zn binding site [ion binding]; other site 362663003470 Repair protein; Region: Repair_PSII; pfam04536 362663003471 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 362663003472 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 362663003473 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 362663003474 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 362663003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663003476 dimer interface [polypeptide binding]; other site 362663003477 conserved gate region; other site 362663003478 putative PBP binding loops; other site 362663003479 ABC-ATPase subunit interface; other site 362663003480 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 362663003481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663003482 dimer interface [polypeptide binding]; other site 362663003483 conserved gate region; other site 362663003484 putative PBP binding loops; other site 362663003485 ABC-ATPase subunit interface; other site 362663003486 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 362663003487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663003488 Walker A/P-loop; other site 362663003489 ATP binding site [chemical binding]; other site 362663003490 Q-loop/lid; other site 362663003491 ABC transporter signature motif; other site 362663003492 Walker B; other site 362663003493 D-loop; other site 362663003494 H-loop/switch region; other site 362663003495 TOBE domain; Region: TOBE_2; pfam08402 362663003496 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 362663003497 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 362663003498 metal binding site [ion binding]; metal-binding site 362663003499 dimer interface [polypeptide binding]; other site 362663003500 Uncharacterized conserved protein [Function unknown]; Region: COG2850 362663003501 Cupin-like domain; Region: Cupin_8; pfam13621 362663003502 sensor protein PhoQ; Provisional; Region: PRK10815 362663003503 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 362663003504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 362663003505 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 362663003506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663003507 ATP binding site [chemical binding]; other site 362663003508 Mg2+ binding site [ion binding]; other site 362663003509 G-X-G motif; other site 362663003510 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 362663003511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663003512 active site 362663003513 phosphorylation site [posttranslational modification] 362663003514 intermolecular recognition site; other site 362663003515 dimerization interface [polypeptide binding]; other site 362663003516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663003517 DNA binding site [nucleotide binding] 362663003518 adenylosuccinate lyase; Provisional; Region: PRK09285 362663003519 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 362663003520 tetramer interface [polypeptide binding]; other site 362663003521 active site 362663003522 putative lysogenization regulator; Reviewed; Region: PRK00218 362663003523 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 362663003524 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 362663003525 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 362663003526 nudix motif; other site 362663003527 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 362663003528 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 362663003529 probable active site [active] 362663003530 isocitrate dehydrogenase; Validated; Region: PRK07362 362663003531 isocitrate dehydrogenase; Reviewed; Region: PRK07006 362663003532 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 362663003533 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362663003534 active site 362663003535 Int/Topo IB signature motif; other site 362663003536 transposase/IS protein; Provisional; Region: PRK09183 362663003537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663003538 Walker A motif; other site 362663003539 ATP binding site [chemical binding]; other site 362663003540 Walker B motif; other site 362663003541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663003542 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663003543 DNA-binding interface [nucleotide binding]; DNA binding site 362663003544 Integrase core domain; Region: rve; pfam00665 362663003545 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 362663003546 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 362663003547 DksA-like zinc finger domain containing protein; Region: PHA00080 362663003548 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 362663003549 phage recombination protein Bet; Region: bet_lambda; TIGR01913 362663003550 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 362663003551 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 362663003552 Uncharacterized conserved protein [Function unknown]; Region: COG4933 362663003553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663003554 non-specific DNA binding site [nucleotide binding]; other site 362663003555 Predicted transcriptional regulator [Transcription]; Region: COG2932 362663003556 salt bridge; other site 362663003557 sequence-specific DNA binding site [nucleotide binding]; other site 362663003558 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 362663003559 Catalytic site [active] 362663003560 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 362663003561 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 362663003562 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 362663003563 Replication protein P; Region: Phage_lambda_P; pfam06992 362663003564 hypothetical protein; Provisional; Region: PRK09741 362663003565 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 362663003566 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 362663003567 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 362663003568 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663003569 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663003570 trimer interface [polypeptide binding]; other site 362663003571 eyelet of channel; other site 362663003572 Lysis protein S; Region: Lysis_S; pfam04971 362663003573 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 362663003574 catalytic residues [active] 362663003575 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 362663003576 Bor protein; Region: Lambda_Bor; pfam06291 362663003577 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 362663003578 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 362663003579 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 362663003580 gpW; Region: gpW; pfam02831 362663003581 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 362663003582 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 362663003583 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 362663003584 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 362663003585 tandem repeat interface [polypeptide binding]; other site 362663003586 oligomer interface [polypeptide binding]; other site 362663003587 active site residues [active] 362663003588 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 362663003589 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 362663003590 DNA packaging protein FI; Region: Packaging_FI; pfam14000 362663003591 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 362663003592 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 362663003593 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 362663003594 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 362663003595 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 362663003596 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 362663003597 Minor tail protein T; Region: Phage_tail_T; pfam06223 362663003598 Phage-related minor tail protein [Function unknown]; Region: COG5281 362663003599 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 362663003600 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 362663003601 Phage-related protein [Function unknown]; Region: COG4718 362663003602 Phage-related protein [Function unknown]; Region: gp18; COG4672 362663003603 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 362663003604 MPN+ (JAMM) motif; other site 362663003605 Zinc-binding site [ion binding]; other site 362663003606 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 362663003607 NlpC/P60 family; Region: NLPC_P60; cl17555 362663003608 Phage-related protein, tail component [Function unknown]; Region: COG4723 362663003609 Phage-related protein, tail component [Function unknown]; Region: COG4733 362663003610 Putative phage tail protein; Region: Phage-tail_3; pfam13550 362663003611 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 362663003612 Interdomain contacts; other site 362663003613 Cytokine receptor motif; other site 362663003614 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 362663003615 Fibronectin type III protein; Region: DUF3672; pfam12421 362663003616 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 362663003617 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 362663003618 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362663003619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663003620 ABC-ATPase subunit interface; other site 362663003621 dimer interface [polypeptide binding]; other site 362663003622 putative PBP binding regions; other site 362663003623 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362663003624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663003625 ABC-ATPase subunit interface; other site 362663003626 dimer interface [polypeptide binding]; other site 362663003627 putative PBP binding regions; other site 362663003628 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 362663003629 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 362663003630 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 362663003631 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 362663003632 metal binding site [ion binding]; metal-binding site 362663003633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 362663003634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663003635 Coenzyme A binding pocket [chemical binding]; other site 362663003636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362663003637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663003638 sequence-specific DNA binding site [nucleotide binding]; other site 362663003639 salt bridge; other site 362663003640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362663003641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663003642 Coenzyme A binding pocket [chemical binding]; other site 362663003643 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 362663003644 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 362663003645 transcriptional regulator MirA; Provisional; Region: PRK15043 362663003646 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 362663003647 DNA binding residues [nucleotide binding] 362663003648 Sensors of blue-light using FAD; Region: BLUF; smart01034 362663003649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663003650 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 362663003651 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 362663003652 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663003653 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 362663003654 Autotransporter beta-domain; Region: Autotransporter; cl17461 362663003655 Autotransporter beta-domain; Region: Autotransporter; smart00869 362663003656 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 362663003657 cell division inhibitor MinD; Provisional; Region: PRK10818 362663003658 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 362663003659 Switch I; other site 362663003660 Switch II; other site 362663003661 septum formation inhibitor; Reviewed; Region: minC; PRK03511 362663003662 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 362663003663 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 362663003664 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 362663003665 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 362663003666 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 362663003667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 362663003668 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 362663003669 hypothetical protein; Provisional; Region: PRK10691 362663003670 hypothetical protein; Provisional; Region: PRK05170 362663003671 Haemolysin E (HlyE); Region: HlyE; cl11627 362663003672 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 362663003673 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 362663003674 Catalytic site [active] 362663003675 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 362663003676 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 362663003677 active site 362663003678 DNA binding site [nucleotide binding] 362663003679 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 362663003680 disulfide bond formation protein B; Provisional; Region: PRK01749 362663003681 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 362663003682 transmembrane helices; other site 362663003683 fatty acid metabolism regulator; Provisional; Region: PRK04984 362663003684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663003685 DNA-binding site [nucleotide binding]; DNA binding site 362663003686 FadR C-terminal domain; Region: FadR_C; pfam07840 362663003687 SpoVR family protein; Provisional; Region: PRK11767 362663003688 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 362663003689 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 362663003690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663003691 alanine racemase; Reviewed; Region: dadX; PRK03646 362663003692 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 362663003693 active site 362663003694 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663003695 substrate binding site [chemical binding]; other site 362663003696 catalytic residues [active] 362663003697 dimer interface [polypeptide binding]; other site 362663003698 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 362663003699 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 362663003700 TrkA-C domain; Region: TrkA_C; pfam02080 362663003701 Transporter associated domain; Region: CorC_HlyC; smart01091 362663003702 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 362663003703 dimer interface [polypeptide binding]; other site 362663003704 catalytic triad [active] 362663003705 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 362663003706 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663003707 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663003708 catalytic residue [active] 362663003709 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 362663003710 Flagellar regulator YcgR; Region: YcgR; pfam07317 362663003711 PilZ domain; Region: PilZ; pfam07238 362663003712 hypothetical protein; Provisional; Region: PRK10457 362663003713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663003714 N-terminal plug; other site 362663003715 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 362663003716 ligand-binding site [chemical binding]; other site 362663003717 molybdenum transport protein ModD; Provisional; Region: PRK06096 362663003718 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 362663003719 dimerization interface [polypeptide binding]; other site 362663003720 active site 362663003721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 362663003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663003723 S-adenosylmethionine binding site [chemical binding]; other site 362663003724 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 362663003725 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663003726 Walker A/P-loop; other site 362663003727 ATP binding site [chemical binding]; other site 362663003728 Q-loop/lid; other site 362663003729 ABC transporter signature motif; other site 362663003730 Walker B; other site 362663003731 D-loop; other site 362663003732 H-loop/switch region; other site 362663003733 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663003734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663003735 ABC-ATPase subunit interface; other site 362663003736 dimer interface [polypeptide binding]; other site 362663003737 putative PBP binding regions; other site 362663003738 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 362663003739 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 362663003740 putative metal binding site [ion binding]; other site 362663003741 trehalase; Provisional; Region: treA; PRK13271 362663003742 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 362663003743 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 362663003744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 362663003745 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663003746 dimerization domain swap beta strand [polypeptide binding]; other site 362663003747 regulatory protein interface [polypeptide binding]; other site 362663003748 active site 362663003749 regulatory phosphorylation site [posttranslational modification]; other site 362663003750 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 362663003751 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663003752 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 362663003753 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 362663003754 Dak1 domain; Region: Dak1; pfam02733 362663003755 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 362663003756 PAS domain; Region: PAS; smart00091 362663003757 putative active site [active] 362663003758 heme pocket [chemical binding]; other site 362663003759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663003760 Walker A motif; other site 362663003761 ATP binding site [chemical binding]; other site 362663003762 Walker B motif; other site 362663003763 arginine finger; other site 362663003764 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663003765 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 362663003766 GTP-binding protein YchF; Reviewed; Region: PRK09601 362663003767 YchF GTPase; Region: YchF; cd01900 362663003768 G1 box; other site 362663003769 GTP/Mg2+ binding site [chemical binding]; other site 362663003770 Switch I region; other site 362663003771 G2 box; other site 362663003772 Switch II region; other site 362663003773 G3 box; other site 362663003774 G4 box; other site 362663003775 G5 box; other site 362663003776 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 362663003777 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 362663003778 putative active site [active] 362663003779 catalytic residue [active] 362663003780 hypothetical protein; Provisional; Region: PRK10692 362663003781 putative transporter; Provisional; Region: PRK11660 362663003782 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 362663003783 Sulfate transporter family; Region: Sulfate_transp; pfam00916 362663003784 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 362663003785 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 362663003786 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 362663003787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663003788 active site 362663003789 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 362663003790 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 362663003791 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 362663003792 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 362663003793 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 362663003794 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 362663003795 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 362663003796 tRNA; other site 362663003797 putative tRNA binding site [nucleotide binding]; other site 362663003798 putative NADP binding site [chemical binding]; other site 362663003799 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 362663003800 peptide chain release factor 1; Validated; Region: prfA; PRK00591 362663003801 This domain is found in peptide chain release factors; Region: PCRF; smart00937 362663003802 RF-1 domain; Region: RF-1; pfam00472 362663003803 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 362663003804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663003805 hypothetical protein; Provisional; Region: PRK10278 362663003806 hypothetical protein; Provisional; Region: PRK10941 362663003807 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 362663003808 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 362663003809 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 362663003810 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 362663003811 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 362663003812 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 362663003813 cation transport regulator; Reviewed; Region: chaB; PRK09582 362663003814 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 362663003815 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 362663003816 putative active site pocket [active] 362663003817 dimerization interface [polypeptide binding]; other site 362663003818 putative catalytic residue [active] 362663003819 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 362663003820 putative invasin; Provisional; Region: PRK10177 362663003821 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 362663003822 transcriptional regulator NarL; Provisional; Region: PRK10651 362663003823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663003824 active site 362663003825 phosphorylation site [posttranslational modification] 362663003826 intermolecular recognition site; other site 362663003827 dimerization interface [polypeptide binding]; other site 362663003828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663003829 DNA binding residues [nucleotide binding] 362663003830 dimerization interface [polypeptide binding]; other site 362663003831 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 362663003832 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 362663003833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663003834 dimerization interface [polypeptide binding]; other site 362663003835 Histidine kinase; Region: HisKA_3; pfam07730 362663003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663003837 ATP binding site [chemical binding]; other site 362663003838 Mg2+ binding site [ion binding]; other site 362663003839 G-X-G motif; other site 362663003840 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 362663003841 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 362663003842 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 362663003843 [4Fe-4S] binding site [ion binding]; other site 362663003844 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663003845 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663003846 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663003847 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 362663003848 molybdopterin cofactor binding site; other site 362663003849 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 362663003850 4Fe-4S binding domain; Region: Fer4; cl02805 362663003851 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 362663003852 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 362663003853 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 362663003854 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 362663003855 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 362663003856 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 362663003857 putative active site [active] 362663003858 putative substrate binding site [chemical binding]; other site 362663003859 putative cosubstrate binding site; other site 362663003860 catalytic site [active] 362663003861 SEC-C motif; Region: SEC-C; pfam02810 362663003862 hypothetical protein; Provisional; Region: PRK04233 362663003863 hypothetical protein; Provisional; Region: PRK10279 362663003864 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 362663003865 active site 362663003866 nucleophile elbow; other site 362663003867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663003868 active site 362663003869 response regulator of RpoS; Provisional; Region: PRK10693 362663003870 phosphorylation site [posttranslational modification] 362663003871 intermolecular recognition site; other site 362663003872 dimerization interface [polypeptide binding]; other site 362663003873 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 362663003874 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 362663003875 active site 362663003876 tetramer interface; other site 362663003877 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 362663003878 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 362663003879 thymidine kinase; Provisional; Region: PRK04296 362663003880 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 362663003881 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 362663003882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 362663003883 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 362663003884 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 362663003885 putative catalytic cysteine [active] 362663003886 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 362663003887 putative active site [active] 362663003888 metal binding site [ion binding]; metal-binding site 362663003889 hypothetical protein; Provisional; Region: PRK11111 362663003890 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 362663003891 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 362663003892 peptide binding site [polypeptide binding]; other site 362663003893 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 362663003894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663003895 dimer interface [polypeptide binding]; other site 362663003896 conserved gate region; other site 362663003897 putative PBP binding loops; other site 362663003898 ABC-ATPase subunit interface; other site 362663003899 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 362663003900 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362663003901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663003902 dimer interface [polypeptide binding]; other site 362663003903 conserved gate region; other site 362663003904 putative PBP binding loops; other site 362663003905 ABC-ATPase subunit interface; other site 362663003906 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 362663003907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663003908 Walker A/P-loop; other site 362663003909 ATP binding site [chemical binding]; other site 362663003910 Q-loop/lid; other site 362663003911 ABC transporter signature motif; other site 362663003912 Walker B; other site 362663003913 D-loop; other site 362663003914 H-loop/switch region; other site 362663003915 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 362663003916 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 362663003917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663003918 Walker A/P-loop; other site 362663003919 ATP binding site [chemical binding]; other site 362663003920 Q-loop/lid; other site 362663003921 ABC transporter signature motif; other site 362663003922 Walker B; other site 362663003923 D-loop; other site 362663003924 H-loop/switch region; other site 362663003925 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 362663003926 dsDNA-mimic protein; Reviewed; Region: PRK05094 362663003927 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 362663003928 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 362663003929 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 362663003930 putative active site [active] 362663003931 catalytic site [active] 362663003932 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 362663003933 putative active site [active] 362663003934 catalytic site [active] 362663003935 voltage-gated potassium channel; Provisional; Region: PRK10537 362663003936 Ion channel; Region: Ion_trans_2; pfam07885 362663003937 TrkA-N domain; Region: TrkA_N; pfam02254 362663003938 YciI-like protein; Reviewed; Region: PRK11370 362663003939 transport protein TonB; Provisional; Region: PRK10819 362663003940 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 362663003941 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 362663003942 intracellular septation protein A; Reviewed; Region: PRK00259 362663003943 hypothetical protein; Provisional; Region: PRK02868 362663003944 outer membrane protein W; Provisional; Region: PRK10959 362663003945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 362663003946 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 362663003947 dimerization interface [polypeptide binding]; other site 362663003948 metal binding site [ion binding]; metal-binding site 362663003949 General stress protein [General function prediction only]; Region: GsiB; COG3729 362663003950 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 362663003951 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 362663003952 substrate binding site [chemical binding]; other site 362663003953 active site 362663003954 catalytic residues [active] 362663003955 heterodimer interface [polypeptide binding]; other site 362663003956 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 362663003957 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 362663003958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663003959 catalytic residue [active] 362663003960 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 362663003961 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 362663003962 active site 362663003963 ribulose/triose binding site [chemical binding]; other site 362663003964 phosphate binding site [ion binding]; other site 362663003965 substrate (anthranilate) binding pocket [chemical binding]; other site 362663003966 product (indole) binding pocket [chemical binding]; other site 362663003967 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 362663003968 active site 362663003969 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 362663003970 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 362663003971 glutamine binding [chemical binding]; other site 362663003972 catalytic triad [active] 362663003973 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 362663003974 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 362663003975 anthranilate synthase component I; Provisional; Region: PRK13564 362663003976 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 362663003977 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 362663003978 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 362663003979 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 362663003980 active site 362663003981 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 362663003982 hypothetical protein; Provisional; Region: PRK11630 362663003983 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 362663003984 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 362663003985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663003986 RNA binding surface [nucleotide binding]; other site 362663003987 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 362663003988 probable active site [active] 362663003989 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 362663003990 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 362663003991 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 362663003992 homodimer interface [polypeptide binding]; other site 362663003993 Walker A motif; other site 362663003994 ATP binding site [chemical binding]; other site 362663003995 hydroxycobalamin binding site [chemical binding]; other site 362663003996 Walker B motif; other site 362663003997 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 362663003998 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 362663003999 NADP binding site [chemical binding]; other site 362663004000 homodimer interface [polypeptide binding]; other site 362663004001 active site 362663004002 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 362663004003 putative inner membrane peptidase; Provisional; Region: PRK11778 362663004004 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 362663004005 tandem repeat interface [polypeptide binding]; other site 362663004006 oligomer interface [polypeptide binding]; other site 362663004007 active site residues [active] 362663004008 hypothetical protein; Provisional; Region: PRK11037 362663004009 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 362663004010 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 362663004011 active site 362663004012 interdomain interaction site; other site 362663004013 putative metal-binding site [ion binding]; other site 362663004014 nucleotide binding site [chemical binding]; other site 362663004015 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 362663004016 domain I; other site 362663004017 DNA binding groove [nucleotide binding] 362663004018 phosphate binding site [ion binding]; other site 362663004019 domain II; other site 362663004020 domain III; other site 362663004021 nucleotide binding site [chemical binding]; other site 362663004022 catalytic site [active] 362663004023 domain IV; other site 362663004024 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362663004025 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362663004026 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 362663004027 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 362663004028 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 362663004029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004030 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 362663004031 substrate binding site [chemical binding]; other site 362663004032 putative dimerization interface [polypeptide binding]; other site 362663004033 aconitate hydratase; Validated; Region: PRK09277 362663004034 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 362663004035 substrate binding site [chemical binding]; other site 362663004036 ligand binding site [chemical binding]; other site 362663004037 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 362663004038 substrate binding site [chemical binding]; other site 362663004039 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 362663004040 dimerization interface [polypeptide binding]; other site 362663004041 active site 362663004042 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362663004043 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 362663004044 active site 362663004045 Predicted membrane protein [Function unknown]; Region: COG3771 362663004046 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 362663004047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 362663004048 TPR motif; other site 362663004049 binding surface 362663004050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663004051 binding surface 362663004052 TPR motif; other site 362663004053 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 362663004054 active site 362663004055 dimer interface [polypeptide binding]; other site 362663004056 translation initiation factor Sui1; Validated; Region: PRK06824 362663004057 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 362663004058 putative rRNA binding site [nucleotide binding]; other site 362663004059 lipoprotein; Provisional; Region: PRK10540 362663004060 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663004061 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663004062 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663004063 hypothetical protein; Provisional; Region: PRK13658 362663004064 RNase II stability modulator; Provisional; Region: PRK10060 362663004065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663004066 putative active site [active] 362663004067 heme pocket [chemical binding]; other site 362663004068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004069 metal binding site [ion binding]; metal-binding site 362663004070 active site 362663004071 I-site; other site 362663004072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663004073 exoribonuclease II; Provisional; Region: PRK05054 362663004074 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 362663004075 RNB domain; Region: RNB; pfam00773 362663004076 S1 RNA binding domain; Region: S1; pfam00575 362663004077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 362663004078 Uncharacterized conserved protein [Function unknown]; Region: COG2128 362663004079 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 362663004080 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 362663004081 NAD binding site [chemical binding]; other site 362663004082 homotetramer interface [polypeptide binding]; other site 362663004083 homodimer interface [polypeptide binding]; other site 362663004084 substrate binding site [chemical binding]; other site 362663004085 active site 362663004086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663004087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663004088 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 362663004089 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663004090 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663004091 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 362663004092 Protein export membrane protein; Region: SecD_SecF; cl14618 362663004093 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 362663004094 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 362663004095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004096 putative substrate translocation pore; other site 362663004097 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 362663004098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663004099 Walker A/P-loop; other site 362663004100 ATP binding site [chemical binding]; other site 362663004101 Q-loop/lid; other site 362663004102 ABC transporter signature motif; other site 362663004103 Walker B; other site 362663004104 D-loop; other site 362663004105 H-loop/switch region; other site 362663004106 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 362663004107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663004108 Walker A/P-loop; other site 362663004109 ATP binding site [chemical binding]; other site 362663004110 Q-loop/lid; other site 362663004111 ABC transporter signature motif; other site 362663004112 Walker B; other site 362663004113 D-loop; other site 362663004114 H-loop/switch region; other site 362663004115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362663004116 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 362663004117 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362663004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004119 dimer interface [polypeptide binding]; other site 362663004120 conserved gate region; other site 362663004121 putative PBP binding loops; other site 362663004122 ABC-ATPase subunit interface; other site 362663004123 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 362663004124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004125 dimer interface [polypeptide binding]; other site 362663004126 conserved gate region; other site 362663004127 putative PBP binding loops; other site 362663004128 ABC-ATPase subunit interface; other site 362663004129 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 362663004130 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 362663004131 peptide binding site [polypeptide binding]; other site 362663004132 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 362663004133 4-aminobutyrate transaminase; Provisional; Region: PRK09792 362663004134 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 362663004135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663004136 Walker A motif; other site 362663004137 ATP binding site [chemical binding]; other site 362663004138 Walker B motif; other site 362663004139 arginine finger; other site 362663004140 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 362663004141 phage shock protein PspA; Provisional; Region: PRK10698 362663004142 phage shock protein B; Provisional; Region: pspB; PRK09458 362663004143 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 362663004144 phage shock protein C; Region: phageshock_pspC; TIGR02978 362663004145 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 362663004146 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 362663004147 active site residue [active] 362663004148 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 362663004149 sucrose phosphorylase; Provisional; Region: PRK13840 362663004150 active site 362663004151 homodimer interface [polypeptide binding]; other site 362663004152 catalytic site [active] 362663004153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 362663004154 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 362663004155 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 362663004156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004157 dimer interface [polypeptide binding]; other site 362663004158 conserved gate region; other site 362663004159 putative PBP binding loops; other site 362663004160 ABC-ATPase subunit interface; other site 362663004161 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 362663004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004163 dimer interface [polypeptide binding]; other site 362663004164 conserved gate region; other site 362663004165 putative PBP binding loops; other site 362663004166 ABC-ATPase subunit interface; other site 362663004167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663004168 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 362663004169 putative NAD(P) binding site [chemical binding]; other site 362663004170 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 362663004171 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362663004172 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663004173 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362663004174 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 362663004175 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 362663004176 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 362663004177 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 362663004178 beta-phosphoglucomutase; Region: bPGM; TIGR01990 362663004179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663004180 motif II; other site 362663004181 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 362663004182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663004183 Walker A/P-loop; other site 362663004184 ATP binding site [chemical binding]; other site 362663004185 Q-loop/lid; other site 362663004186 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 362663004187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663004188 ABC transporter signature motif; other site 362663004189 Walker B; other site 362663004190 D-loop; other site 362663004191 H-loop/switch region; other site 362663004192 TOBE domain; Region: TOBE_2; pfam08402 362663004193 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 362663004194 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362663004195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663004196 DNA binding site [nucleotide binding] 362663004197 domain linker motif; other site 362663004198 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 362663004199 putative dimerization interface [polypeptide binding]; other site 362663004200 putative ligand binding site [chemical binding]; other site 362663004201 Predicted ATPase [General function prediction only]; Region: COG3106 362663004202 hypothetical protein; Provisional; Region: PRK05415 362663004203 TIGR01620 family protein; Region: hyp_HI0043 362663004204 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 362663004205 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 362663004206 putative aromatic amino acid binding site; other site 362663004207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663004208 Walker A motif; other site 362663004209 ATP binding site [chemical binding]; other site 362663004210 Walker B motif; other site 362663004211 arginine finger; other site 362663004212 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 362663004213 dimer interface [polypeptide binding]; other site 362663004214 catalytic triad [active] 362663004215 peroxidatic and resolving cysteines [active] 362663004216 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 362663004217 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 362663004218 active site 362663004219 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 362663004220 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 362663004221 putative active site [active] 362663004222 Zn binding site [ion binding]; other site 362663004223 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 362663004224 NADH(P)-binding; Region: NAD_binding_10; pfam13460 362663004225 putative NAD(P) binding site [chemical binding]; other site 362663004226 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 362663004227 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 362663004228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663004229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004230 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 362663004231 putative effector binding pocket; other site 362663004232 putative dimerization interface [polypeptide binding]; other site 362663004233 periplasmic murein peptide-binding protein precursor nonfunction due to the frame shift 362663004234 periplasmic murein peptide-binding protein precursor nonfunction due to the frame shift 362663004235 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 362663004236 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663004237 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 362663004238 universal stress protein UspE; Provisional; Region: PRK11175 362663004239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663004240 Ligand Binding Site [chemical binding]; other site 362663004241 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663004242 Ligand Binding Site [chemical binding]; other site 362663004243 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 362663004244 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 362663004245 ligand binding site [chemical binding]; other site 362663004246 flexible hinge region; other site 362663004247 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 362663004248 putative switch regulator; other site 362663004249 non-specific DNA interactions [nucleotide binding]; other site 362663004250 DNA binding site [nucleotide binding] 362663004251 sequence specific DNA binding site [nucleotide binding]; other site 362663004252 putative cAMP binding site [chemical binding]; other site 362663004253 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 362663004254 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 362663004255 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 362663004256 DNA binding site [nucleotide binding] 362663004257 active site 362663004258 Cupin domain; Region: Cupin_2; cl17218 362663004259 Helix-turn-helix domain; Region: HTH_18; pfam12833 362663004260 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 362663004261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663004262 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663004263 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 362663004264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004265 putative substrate translocation pore; other site 362663004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 362663004268 Smr domain; Region: Smr; pfam01713 362663004269 PAS domain S-box; Region: sensory_box; TIGR00229 362663004270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663004271 putative active site [active] 362663004272 heme pocket [chemical binding]; other site 362663004273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663004274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004275 metal binding site [ion binding]; metal-binding site 362663004276 active site 362663004277 I-site; other site 362663004278 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 362663004279 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 362663004280 Cl binding site [ion binding]; other site 362663004281 oligomer interface [polypeptide binding]; other site 362663004282 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 362663004283 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362663004284 ATP binding site [chemical binding]; other site 362663004285 Mg++ binding site [ion binding]; other site 362663004286 motif III; other site 362663004287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663004288 nucleotide binding region [chemical binding]; other site 362663004289 ATP-binding site [chemical binding]; other site 362663004290 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 362663004291 putative RNA binding site [nucleotide binding]; other site 362663004292 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 362663004293 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 362663004294 Ligand Binding Site [chemical binding]; other site 362663004295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663004296 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 362663004297 DNA binding site [nucleotide binding] 362663004298 active site 362663004299 Int/Topo IB signature motif; other site 362663004300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 362663004301 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362663004302 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663004303 Ligand Binding Site [chemical binding]; other site 362663004304 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663004305 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663004306 trimer interface [polypeptide binding]; other site 362663004307 eyelet of channel; other site 362663004308 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 362663004309 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 362663004310 dimer interface [polypeptide binding]; other site 362663004311 PYR/PP interface [polypeptide binding]; other site 362663004312 TPP binding site [chemical binding]; other site 362663004313 substrate binding site [chemical binding]; other site 362663004314 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 362663004315 Domain of unknown function; Region: EKR; smart00890 362663004316 4Fe-4S binding domain; Region: Fer4_6; pfam12837 362663004317 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663004318 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 362663004319 TPP-binding site [chemical binding]; other site 362663004320 dimer interface [polypeptide binding]; other site 362663004321 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 362663004322 Domain of unknown function (DUF333); Region: DUF333; pfam03891 362663004323 heat-inducible protein; Provisional; Region: PRK10449 362663004324 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 362663004325 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 362663004326 putative ligand binding site [chemical binding]; other site 362663004327 putative NAD binding site [chemical binding]; other site 362663004328 catalytic site [active] 362663004329 hypothetical protein; Provisional; Region: PRK10695 362663004330 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 362663004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 362663004332 Autotransporter beta-domain; Region: Autotransporter; pfam03797 362663004333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663004334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663004335 active site 362663004336 catalytic tetrad [active] 362663004337 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 362663004338 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 362663004339 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 362663004340 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 362663004341 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 362663004342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663004343 S-adenosylmethionine binding site [chemical binding]; other site 362663004344 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 362663004345 active site 362663004346 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 362663004347 active site 362663004348 catalytic residues [active] 362663004349 azoreductase; Reviewed; Region: PRK00170 362663004350 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362663004351 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 362663004352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663004353 ATP binding site [chemical binding]; other site 362663004354 putative Mg++ binding site [ion binding]; other site 362663004355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663004356 nucleotide binding region [chemical binding]; other site 362663004357 ATP-binding site [chemical binding]; other site 362663004358 Helicase associated domain (HA2); Region: HA2; pfam04408 362663004359 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 362663004360 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 362663004361 Uncharacterized conserved protein [Function unknown]; Region: COG1434 362663004362 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 362663004363 putative active site [active] 362663004364 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 362663004365 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 362663004366 NAD binding site [chemical binding]; other site 362663004367 catalytic residues [active] 362663004368 substrate binding site [chemical binding]; other site 362663004369 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 362663004370 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 362663004371 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 362663004372 cytochrome b561; Provisional; Region: PRK11513 362663004373 hypothetical protein; Provisional; Region: PRK10040 362663004374 methyl-accepting chemotaxis protein III nonfunction due to the frame shift 362663004375 methyl-accepting chemotaxis protein III nonfunction due to the frame shift 362663004376 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 362663004377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663004379 dimerization interface [polypeptide binding]; other site 362663004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 362663004381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 362663004382 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 362663004383 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 362663004384 hypothetical protein; Provisional; Region: PRK11415 362663004385 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 362663004386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663004387 Coenzyme A binding pocket [chemical binding]; other site 362663004388 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362663004389 putative trimer interface [polypeptide binding]; other site 362663004390 putative CoA binding site [chemical binding]; other site 362663004391 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 362663004392 putative trimer interface [polypeptide binding]; other site 362663004393 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362663004394 putative CoA binding site [chemical binding]; other site 362663004395 putative trimer interface [polypeptide binding]; other site 362663004396 putative CoA binding site [chemical binding]; other site 362663004397 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 362663004398 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 362663004399 gating phenylalanine in ion channel; other site 362663004400 tellurite resistance protein TehB; Provisional; Region: PRK11207 362663004401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663004402 S-adenosylmethionine binding site [chemical binding]; other site 362663004403 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 362663004404 benzoate transporter; Region: benE; TIGR00843 362663004405 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 362663004406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362663004407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663004408 non-specific DNA binding site [nucleotide binding]; other site 362663004409 salt bridge; other site 362663004410 sequence-specific DNA binding site [nucleotide binding]; other site 362663004411 Cupin domain; Region: Cupin_2; pfam07883 362663004412 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 362663004413 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 362663004414 Peptidase family U32; Region: Peptidase_U32; pfam01136 362663004415 Collagenase; Region: DUF3656; pfam12392 362663004416 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 362663004417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 362663004418 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 362663004419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663004420 DNA-binding site [nucleotide binding]; DNA binding site 362663004421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663004422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663004423 homodimer interface [polypeptide binding]; other site 362663004424 catalytic residue [active] 362663004425 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 362663004426 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 362663004427 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 362663004428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663004429 Walker A/P-loop; other site 362663004430 ATP binding site [chemical binding]; other site 362663004431 Q-loop/lid; other site 362663004432 ABC transporter signature motif; other site 362663004433 Walker B; other site 362663004434 D-loop; other site 362663004435 H-loop/switch region; other site 362663004436 TOBE domain; Region: TOBE_2; pfam08402 362663004437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004438 dimer interface [polypeptide binding]; other site 362663004439 conserved gate region; other site 362663004440 putative PBP binding loops; other site 362663004441 ABC-ATPase subunit interface; other site 362663004442 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 362663004443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663004444 ABC-ATPase subunit interface; other site 362663004445 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 362663004446 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 362663004447 tetrameric interface [polypeptide binding]; other site 362663004448 NAD binding site [chemical binding]; other site 362663004449 catalytic residues [active] 362663004450 substrate binding site [chemical binding]; other site 362663004451 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 362663004452 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 362663004453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 362663004454 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 362663004455 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 362663004456 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 362663004457 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 362663004458 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663004459 N-terminal plug; other site 362663004460 ligand-binding site [chemical binding]; other site 362663004461 PQQ-like domain; Region: PQQ_2; pfam13360 362663004462 L-asparagine permease; Provisional; Region: PRK15049 362663004463 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 362663004464 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 362663004465 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 362663004466 N-terminal domain interface [polypeptide binding]; other site 362663004467 dimer interface [polypeptide binding]; other site 362663004468 substrate binding pocket (H-site) [chemical binding]; other site 362663004469 PAAR motif; Region: PAAR_motif; pfam05488 362663004470 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 362663004471 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 362663004472 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 362663004473 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 362663004474 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 362663004475 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 362663004476 putative active site [active] 362663004477 putative Zn binding site [ion binding]; other site 362663004478 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 362663004479 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 362663004480 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 362663004481 hypothetical protein; Provisional; Region: PRK10281 362663004482 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 362663004483 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 362663004484 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 362663004485 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 362663004486 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 362663004487 [4Fe-4S] binding site [ion binding]; other site 362663004488 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004489 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004490 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004491 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 362663004492 molybdopterin cofactor binding site; other site 362663004493 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 362663004494 aromatic amino acid exporter; Provisional; Region: PRK11689 362663004495 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004496 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004497 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 362663004498 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 362663004499 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 362663004500 molybdopterin cofactor binding site; other site 362663004501 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 362663004502 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 362663004503 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 362663004504 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 362663004505 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 362663004506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663004507 non-specific DNA binding site [nucleotide binding]; other site 362663004508 salt bridge; other site 362663004509 sequence-specific DNA binding site [nucleotide binding]; other site 362663004510 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 362663004511 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 362663004512 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 362663004513 NAD binding site [chemical binding]; other site 362663004514 substrate binding site [chemical binding]; other site 362663004515 catalytic Zn binding site [ion binding]; other site 362663004516 tetramer interface [polypeptide binding]; other site 362663004517 structural Zn binding site [ion binding]; other site 362663004518 malate dehydrogenase; Provisional; Region: PRK13529 362663004519 Malic enzyme, N-terminal domain; Region: malic; pfam00390 362663004520 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 362663004521 NAD(P) binding site [chemical binding]; other site 362663004522 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 362663004523 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 362663004524 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 362663004525 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 362663004526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663004527 putative active site [active] 362663004528 heme pocket [chemical binding]; other site 362663004529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663004530 putative active site [active] 362663004531 heme pocket [chemical binding]; other site 362663004532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004533 metal binding site [ion binding]; metal-binding site 362663004534 active site 362663004535 I-site; other site 362663004536 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663004537 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663004538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 362663004540 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 362663004541 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 362663004542 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 362663004543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663004544 catalytic residue [active] 362663004545 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 362663004546 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 362663004547 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362663004548 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 362663004549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362663004550 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 362663004551 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 362663004552 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 362663004553 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 362663004554 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 362663004555 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 362663004556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663004557 FeS/SAM binding site; other site 362663004558 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 362663004559 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 362663004560 Sulfatase; Region: Sulfatase; pfam00884 362663004561 transcriptional regulator YdeO; Provisional; Region: PRK09940 362663004562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663004563 putative oxidoreductase; Provisional; Region: PRK09939 362663004564 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 362663004565 putative molybdopterin cofactor binding site [chemical binding]; other site 362663004566 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 362663004567 putative molybdopterin cofactor binding site; other site 362663004568 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663004569 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663004570 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 362663004571 PapC C-terminal domain; Region: PapC_C; pfam13953 362663004572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663004573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663004575 dimerization interface [polypeptide binding]; other site 362663004576 HipA N-terminal domain; Region: Couple_hipA; pfam13657 362663004577 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 362663004578 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 362663004579 HipA-like C-terminal domain; Region: HipA_C; pfam07804 362663004580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362663004581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663004582 non-specific DNA binding site [nucleotide binding]; other site 362663004583 salt bridge; other site 362663004584 sequence-specific DNA binding site [nucleotide binding]; other site 362663004585 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 362663004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663004587 S-adenosylmethionine binding site [chemical binding]; other site 362663004588 Predicted membrane protein [Function unknown]; Region: COG3781 362663004589 altronate oxidoreductase; Provisional; Region: PRK03643 362663004590 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663004591 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663004592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663004593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004594 metal binding site [ion binding]; metal-binding site 362663004595 active site 362663004596 I-site; other site 362663004597 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 362663004598 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 362663004599 glutaminase; Provisional; Region: PRK00971 362663004600 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 362663004601 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 362663004602 NAD(P) binding site [chemical binding]; other site 362663004603 catalytic residues [active] 362663004604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663004605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004606 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 362663004607 putative dimerization interface [polypeptide binding]; other site 362663004608 putative arabinose transporter; Provisional; Region: PRK03545 362663004609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004610 putative substrate translocation pore; other site 362663004611 inner membrane protein; Provisional; Region: PRK10995 362663004612 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 362663004613 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663004614 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 362663004615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663004616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663004617 hypothetical protein; Provisional; Region: PRK10106 362663004618 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 362663004619 beta-galactosidase; Region: BGL; TIGR03356 362663004620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 362663004621 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 362663004622 UTRA domain; Region: UTRA; pfam07702 362663004623 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 362663004624 EamA-like transporter family; Region: EamA; pfam00892 362663004625 EamA-like transporter family; Region: EamA; pfam00892 362663004626 putative transporter; Provisional; Region: PRK10054 362663004627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004628 putative substrate translocation pore; other site 362663004629 diguanylate cyclase; Provisional; Region: PRK09894 362663004630 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 362663004631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663004632 metal binding site [ion binding]; metal-binding site 362663004633 active site 362663004634 I-site; other site 362663004635 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 362663004636 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 362663004637 active site 362663004638 Zn binding site [ion binding]; other site 362663004639 malonic semialdehyde reductase; Provisional; Region: PRK10538 362663004640 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 362663004641 putative NAD(P) binding site [chemical binding]; other site 362663004642 homodimer interface [polypeptide binding]; other site 362663004643 homotetramer interface [polypeptide binding]; other site 362663004644 active site 362663004645 Transcriptional regulators [Transcription]; Region: GntR; COG1802 362663004646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663004647 DNA-binding site [nucleotide binding]; DNA binding site 362663004648 FCD domain; Region: FCD; pfam07729 362663004649 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 362663004650 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 362663004651 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663004652 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663004653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004654 metabolite-proton symporter; Region: 2A0106; TIGR00883 362663004655 putative substrate translocation pore; other site 362663004656 putative oxidoreductase; Provisional; Region: PRK10083 362663004657 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 362663004658 putative NAD(P) binding site [chemical binding]; other site 362663004659 catalytic Zn binding site [ion binding]; other site 362663004660 structural Zn binding site [ion binding]; other site 362663004661 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 362663004662 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 362663004663 putative active site pocket [active] 362663004664 putative metal binding site [ion binding]; other site 362663004665 hypothetical protein; Provisional; Region: PRK02237 362663004666 hypothetical protein; Provisional; Region: PRK13659 362663004667 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 362663004668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663004669 Coenzyme A binding pocket [chemical binding]; other site 362663004670 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 362663004671 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 362663004672 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 362663004673 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 362663004674 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 362663004675 Cl- selectivity filter; other site 362663004676 Cl- binding residues [ion binding]; other site 362663004677 pore gating glutamate residue; other site 362663004678 dimer interface [polypeptide binding]; other site 362663004679 putative dithiobiotin synthetase; Provisional; Region: PRK12374 362663004680 AAA domain; Region: AAA_26; pfam13500 362663004681 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 362663004682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 362663004683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663004684 nucleotide binding site [chemical binding]; other site 362663004685 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 362663004686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004687 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 362663004688 dimerization interface [polypeptide binding]; other site 362663004689 substrate binding pocket [chemical binding]; other site 362663004690 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 362663004691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004692 putative substrate translocation pore; other site 362663004693 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 362663004694 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 362663004695 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 362663004696 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 362663004697 Domain of unknown function DUF20; Region: UPF0118; pfam01594 362663004698 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 362663004699 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 362663004700 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 362663004701 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 362663004702 ligand binding site [chemical binding]; other site 362663004703 homodimer interface [polypeptide binding]; other site 362663004704 NAD(P) binding site [chemical binding]; other site 362663004705 trimer interface B [polypeptide binding]; other site 362663004706 trimer interface A [polypeptide binding]; other site 362663004707 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 362663004708 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663004709 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663004710 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663004711 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 362663004712 Spore germination protein; Region: Spore_permease; cl17796 362663004713 dihydromonapterin reductase; Provisional; Region: PRK06483 362663004714 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 362663004715 NADP binding site [chemical binding]; other site 362663004716 substrate binding pocket [chemical binding]; other site 362663004717 active site 362663004718 GlpM protein; Region: GlpM; pfam06942 362663004719 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 362663004720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663004721 active site 362663004722 phosphorylation site [posttranslational modification] 362663004723 intermolecular recognition site; other site 362663004724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663004725 DNA binding site [nucleotide binding] 362663004726 sensor protein RstB; Provisional; Region: PRK10604 362663004727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663004728 dimerization interface [polypeptide binding]; other site 362663004729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663004730 dimer interface [polypeptide binding]; other site 362663004731 phosphorylation site [posttranslational modification] 362663004732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663004733 ATP binding site [chemical binding]; other site 362663004734 Mg2+ binding site [ion binding]; other site 362663004735 G-X-G motif; other site 362663004736 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 362663004737 fumarate hydratase; Reviewed; Region: fumC; PRK00485 362663004738 Class II fumarases; Region: Fumarase_classII; cd01362 362663004739 active site 362663004740 tetramer interface [polypeptide binding]; other site 362663004741 fumarate hydratase; Provisional; Region: PRK15389 362663004742 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 362663004743 Fumarase C-terminus; Region: Fumerase_C; pfam05683 362663004744 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 362663004745 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 362663004746 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 362663004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 362663004748 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 362663004749 putative outer membrane porin protein; Provisional; Region: PRK11379 362663004750 glucuronide transporter; Provisional; Region: PRK09848 362663004751 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 362663004752 beta-D-glucuronidase; Provisional; Region: PRK10150 362663004753 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 362663004754 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 362663004755 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 362663004756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663004757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663004758 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 362663004759 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 362663004760 NAD binding site [chemical binding]; other site 362663004761 substrate binding site [chemical binding]; other site 362663004762 homotetramer interface [polypeptide binding]; other site 362663004763 homodimer interface [polypeptide binding]; other site 362663004764 active site 362663004765 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 362663004766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663004767 DNA binding site [nucleotide binding] 362663004768 domain linker motif; other site 362663004769 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 362663004770 putative dimerization interface [polypeptide binding]; other site 362663004771 putative ligand binding site [chemical binding]; other site 362663004772 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 362663004773 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 362663004774 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663004775 active site turn [active] 362663004776 phosphorylation site [posttranslational modification] 362663004777 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 362663004778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663004779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663004780 homodimer interface [polypeptide binding]; other site 362663004781 catalytic residue [active] 362663004782 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 362663004783 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 362663004784 active site 362663004785 purine riboside binding site [chemical binding]; other site 362663004786 putative oxidoreductase; Provisional; Region: PRK11579 362663004787 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663004788 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362663004789 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 362663004790 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 362663004791 electron transport complex protein RsxA; Provisional; Region: PRK05151 362663004792 electron transport complex protein RnfB; Provisional; Region: PRK05113 362663004793 Putative Fe-S cluster; Region: FeS; pfam04060 362663004794 4Fe-4S binding domain; Region: Fer4; pfam00037 362663004795 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 362663004796 SLBB domain; Region: SLBB; pfam10531 362663004797 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663004798 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 362663004799 electron transport complex protein RnfG; Validated; Region: PRK01908 362663004800 electron transport complex RsxE subunit; Provisional; Region: PRK12405 362663004801 endonuclease III; Provisional; Region: PRK10702 362663004802 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 362663004803 minor groove reading motif; other site 362663004804 helix-hairpin-helix signature motif; other site 362663004805 substrate binding pocket [chemical binding]; other site 362663004806 active site 362663004807 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 362663004808 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 362663004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004810 putative substrate translocation pore; other site 362663004811 POT family; Region: PTR2; pfam00854 362663004812 glutathionine S-transferase; Provisional; Region: PRK10542 362663004813 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 362663004814 C-terminal domain interface [polypeptide binding]; other site 362663004815 GSH binding site (G-site) [chemical binding]; other site 362663004816 dimer interface [polypeptide binding]; other site 362663004817 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 362663004818 N-terminal domain interface [polypeptide binding]; other site 362663004819 dimer interface [polypeptide binding]; other site 362663004820 substrate binding pocket (H-site) [chemical binding]; other site 362663004821 pyridoxamine kinase; Validated; Region: PRK05756 362663004822 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 362663004823 dimer interface [polypeptide binding]; other site 362663004824 pyridoxal binding site [chemical binding]; other site 362663004825 ATP binding site [chemical binding]; other site 362663004826 tyrosyl-tRNA synthetase nonfunction due to the frame shift 362663004827 tyrosyl-tRNA synthetase nonfunction due to the frame shift 362663004828 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 362663004829 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 362663004830 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 362663004831 lysozyme inhibitor; Provisional; Region: PRK11372 362663004832 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 362663004833 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 362663004834 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 362663004835 transcriptional regulator SlyA; Provisional; Region: PRK03573 362663004836 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 362663004837 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 362663004838 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 362663004839 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663004840 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663004841 Fusaric acid resistance protein family; Region: FUSC; pfam04632 362663004842 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663004843 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 362663004844 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 362663004845 E-class dimer interface [polypeptide binding]; other site 362663004846 P-class dimer interface [polypeptide binding]; other site 362663004847 active site 362663004848 Cu2+ binding site [ion binding]; other site 362663004849 Zn2+ binding site [ion binding]; other site 362663004850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663004851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663004852 active site 362663004853 catalytic tetrad [active] 362663004854 Predicted Fe-S protein [General function prediction only]; Region: COG3313 362663004855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663004856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663004857 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 362663004858 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 362663004859 FMN binding site [chemical binding]; other site 362663004860 active site 362663004861 substrate binding site [chemical binding]; other site 362663004862 catalytic residue [active] 362663004863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 362663004864 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 362663004865 dimer interface [polypeptide binding]; other site 362663004866 active site 362663004867 metal binding site [ion binding]; metal-binding site 362663004868 glutathione binding site [chemical binding]; other site 362663004869 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 362663004870 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 362663004871 dimer interface [polypeptide binding]; other site 362663004872 catalytic site [active] 362663004873 putative active site [active] 362663004874 putative substrate binding site [chemical binding]; other site 362663004875 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 362663004876 putative GSH binding site [chemical binding]; other site 362663004877 catalytic residues [active] 362663004878 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 362663004879 NlpC/P60 family; Region: NLPC_P60; pfam00877 362663004880 superoxide dismutase; Provisional; Region: PRK10543 362663004881 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 362663004882 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 362663004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004884 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663004885 putative substrate translocation pore; other site 362663004886 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 362663004887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663004888 DNA binding site [nucleotide binding] 362663004889 domain linker motif; other site 362663004890 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 362663004891 dimerization interface [polypeptide binding]; other site 362663004892 ligand binding site [chemical binding]; other site 362663004893 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 362663004894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663004895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663004896 dimerization interface [polypeptide binding]; other site 362663004897 putative transporter; Provisional; Region: PRK11043 362663004898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004899 putative substrate translocation pore; other site 362663004900 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 362663004901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 362663004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663004903 S-adenosylmethionine binding site [chemical binding]; other site 362663004904 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 362663004905 Lumazine binding domain; Region: Lum_binding; pfam00677 362663004906 Lumazine binding domain; Region: Lum_binding; pfam00677 362663004907 multidrug efflux protein; Reviewed; Region: PRK01766 362663004908 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 362663004909 cation binding site [ion binding]; other site 362663004910 hypothetical protein; Provisional; Region: PRK09945 362663004911 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 362663004912 putative monooxygenase; Provisional; Region: PRK11118 362663004913 hypothetical protein; Provisional; Region: PRK09897 362663004914 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 362663004915 hypothetical protein; Provisional; Region: PRK09946 362663004916 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 362663004917 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 362663004918 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 362663004919 hypothetical protein; Provisional; Region: PRK09947 362663004920 putative oxidoreductase; Provisional; Region: PRK09849 362663004921 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 362663004922 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 362663004923 hypothetical protein; Provisional; Region: PRK09898 362663004924 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663004925 hypothetical protein; Provisional; Region: PRK10292 362663004926 pyruvate kinase; Provisional; Region: PRK09206 362663004927 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 362663004928 active site 362663004929 domain interfaces; other site 362663004930 murein lipoprotein; Provisional; Region: PRK15396 362663004931 L,D-transpeptidase; Provisional; Region: PRK10190 362663004932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663004933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663004934 cysteine desufuration protein SufE; Provisional; Region: PRK09296 362663004935 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 362663004936 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 362663004937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663004938 catalytic residue [active] 362663004939 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 362663004940 FeS assembly protein SufD; Region: sufD; TIGR01981 362663004941 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 362663004942 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 362663004943 Walker A/P-loop; other site 362663004944 ATP binding site [chemical binding]; other site 362663004945 Q-loop/lid; other site 362663004946 ABC transporter signature motif; other site 362663004947 Walker B; other site 362663004948 D-loop; other site 362663004949 H-loop/switch region; other site 362663004950 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 362663004951 putative ABC transporter; Region: ycf24; CHL00085 362663004952 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 362663004953 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 362663004954 CoenzymeA binding site [chemical binding]; other site 362663004955 subunit interaction site [polypeptide binding]; other site 362663004956 PHB binding site; other site 362663004957 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 362663004958 FAD binding domain; Region: FAD_binding_4; pfam01565 362663004959 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 362663004960 putative inner membrane protein; Provisional; Region: PRK10983 362663004961 Domain of unknown function DUF20; Region: UPF0118; pfam01594 362663004962 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 362663004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663004965 putative substrate translocation pore; other site 362663004966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663004967 putative substrate translocation pore; other site 362663004968 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 362663004969 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 362663004970 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 362663004971 shikimate binding site; other site 362663004972 NAD(P) binding site [chemical binding]; other site 362663004973 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 362663004974 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 362663004975 active site 362663004976 catalytic residue [active] 362663004977 dimer interface [polypeptide binding]; other site 362663004978 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 362663004979 Coenzyme A transferase; Region: CoA_trans; smart00882 362663004980 Coenzyme A transferase; Region: CoA_trans; cl17247 362663004981 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 362663004982 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 362663004983 active site 362663004984 Cupin domain; Region: Cupin_2; pfam07883 362663004985 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 362663004986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663004987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663004988 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 362663004989 Ligand binding site [chemical binding]; other site 362663004990 Electron transfer flavoprotein domain; Region: ETF; pfam01012 362663004991 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 362663004992 Electron transfer flavoprotein domain; Region: ETF; smart00893 362663004993 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 362663004994 oxidoreductase; Provisional; Region: PRK10015 362663004995 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 362663004996 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 362663004997 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 362663004998 acyl-activating enzyme (AAE) consensus motif; other site 362663004999 putative AMP binding site [chemical binding]; other site 362663005000 putative active site [active] 362663005001 putative CoA binding site [chemical binding]; other site 362663005002 phosphoenolpyruvate synthase; Validated; Region: PRK06464 362663005003 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 362663005004 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663005005 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663005006 PEP synthetase regulatory protein; Provisional; Region: PRK05339 362663005007 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 362663005008 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 362663005009 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 362663005010 Uncharacterized conserved protein [Function unknown]; Region: COG0397 362663005011 hypothetical protein; Validated; Region: PRK00029 362663005012 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 362663005013 NlpC/P60 family; Region: NLPC_P60; pfam00877 362663005014 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 362663005015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663005016 Walker A/P-loop; other site 362663005017 ATP binding site [chemical binding]; other site 362663005018 Q-loop/lid; other site 362663005019 ABC transporter signature motif; other site 362663005020 Walker B; other site 362663005021 D-loop; other site 362663005022 H-loop/switch region; other site 362663005023 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 362663005024 catalytic residues [active] 362663005025 dimer interface [polypeptide binding]; other site 362663005026 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663005027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663005028 ABC-ATPase subunit interface; other site 362663005029 dimer interface [polypeptide binding]; other site 362663005030 putative PBP binding regions; other site 362663005031 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 362663005032 IHF dimer interface [polypeptide binding]; other site 362663005033 IHF - DNA interface [nucleotide binding]; other site 362663005034 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 362663005035 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 362663005036 putative tRNA-binding site [nucleotide binding]; other site 362663005037 B3/4 domain; Region: B3_4; pfam03483 362663005038 tRNA synthetase B5 domain; Region: B5; smart00874 362663005039 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 362663005040 dimer interface [polypeptide binding]; other site 362663005041 motif 1; other site 362663005042 motif 3; other site 362663005043 motif 2; other site 362663005044 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 362663005045 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 362663005046 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 362663005047 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 362663005048 dimer interface [polypeptide binding]; other site 362663005049 motif 1; other site 362663005050 active site 362663005051 motif 2; other site 362663005052 motif 3; other site 362663005053 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 362663005054 23S rRNA binding site [nucleotide binding]; other site 362663005055 L21 binding site [polypeptide binding]; other site 362663005056 L13 binding site [polypeptide binding]; other site 362663005057 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 362663005058 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 362663005059 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 362663005060 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 362663005061 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 362663005062 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 362663005063 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 362663005064 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 362663005065 active site 362663005066 dimer interface [polypeptide binding]; other site 362663005067 motif 1; other site 362663005068 motif 2; other site 362663005069 motif 3; other site 362663005070 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 362663005071 anticodon binding site; other site 362663005072 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 362663005073 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 362663005074 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 362663005075 6-phosphofructokinase 2; Provisional; Region: PRK10294 362663005076 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 362663005077 putative substrate binding site [chemical binding]; other site 362663005078 putative ATP binding site [chemical binding]; other site 362663005079 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 362663005080 Phosphotransferase enzyme family; Region: APH; pfam01636 362663005081 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 362663005082 active site 362663005083 ATP binding site [chemical binding]; other site 362663005084 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 362663005085 YniB-like protein; Region: YniB; pfam14002 362663005086 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 362663005087 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 362663005088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663005089 motif II; other site 362663005090 inner membrane protein; Provisional; Region: PRK11648 362663005091 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 362663005092 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 362663005093 cell division modulator; Provisional; Region: PRK10113 362663005094 hydroperoxidase II; Provisional; Region: katE; PRK11249 362663005095 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 362663005096 tetramer interface [polypeptide binding]; other site 362663005097 heme binding pocket [chemical binding]; other site 362663005098 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 362663005099 domain interactions; other site 362663005100 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 362663005101 putative active site [active] 362663005102 YdjC motif; other site 362663005103 Mg binding site [ion binding]; other site 362663005104 putative homodimer interface [polypeptide binding]; other site 362663005105 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 362663005106 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 362663005107 NAD binding site [chemical binding]; other site 362663005108 sugar binding site [chemical binding]; other site 362663005109 divalent metal binding site [ion binding]; other site 362663005110 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362663005111 dimer interface [polypeptide binding]; other site 362663005112 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 362663005113 Cupin domain; Region: Cupin_2; pfam07883 362663005114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663005115 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 362663005116 methionine cluster; other site 362663005117 active site 362663005118 phosphorylation site [posttranslational modification] 362663005119 metal binding site [ion binding]; metal-binding site 362663005120 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 362663005121 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 362663005122 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 362663005123 active site 362663005124 P-loop; other site 362663005125 phosphorylation site [posttranslational modification] 362663005126 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 362663005127 NAD+ synthetase; Region: nadE; TIGR00552 362663005128 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 362663005129 homodimer interface [polypeptide binding]; other site 362663005130 NAD binding pocket [chemical binding]; other site 362663005131 ATP binding pocket [chemical binding]; other site 362663005132 Mg binding site [ion binding]; other site 362663005133 active-site loop [active] 362663005134 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 362663005135 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 362663005136 GIY-YIG motif/motif A; other site 362663005137 active site 362663005138 catalytic site [active] 362663005139 putative DNA binding site [nucleotide binding]; other site 362663005140 metal binding site [ion binding]; metal-binding site 362663005141 hypothetical protein; Provisional; Region: PRK11396 362663005142 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 362663005143 dimer interface [polypeptide binding]; other site 362663005144 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 362663005145 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 362663005146 putative active site [active] 362663005147 Zn binding site [ion binding]; other site 362663005148 succinylarginine dihydrolase; Provisional; Region: PRK13281 362663005149 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 362663005150 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 362663005151 NAD(P) binding site [chemical binding]; other site 362663005152 catalytic residues [active] 362663005153 arginine succinyltransferase; Provisional; Region: PRK10456 362663005154 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 362663005155 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 362663005156 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663005157 inhibitor-cofactor binding pocket; inhibition site 362663005158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663005159 catalytic residue [active] 362663005160 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 362663005161 putative catalytic site [active] 362663005162 putative phosphate binding site [ion binding]; other site 362663005163 active site 362663005164 metal binding site A [ion binding]; metal-binding site 362663005165 DNA binding site [nucleotide binding] 362663005166 putative AP binding site [nucleotide binding]; other site 362663005167 putative metal binding site B [ion binding]; other site 362663005168 Uncharacterized conserved protein [Function unknown]; Region: COG0398 362663005169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 362663005170 Uncharacterized conserved protein [Function unknown]; Region: COG0398 362663005171 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 362663005172 Uncharacterized conserved protein [Function unknown]; Region: COG2128 362663005173 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 362663005174 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 362663005175 hypothetical protein; Provisional; Region: PRK11622 362663005176 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 362663005177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663005178 dimer interface [polypeptide binding]; other site 362663005179 conserved gate region; other site 362663005180 putative PBP binding loops; other site 362663005181 ABC-ATPase subunit interface; other site 362663005182 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 362663005183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663005184 Walker A/P-loop; other site 362663005185 ATP binding site [chemical binding]; other site 362663005186 Q-loop/lid; other site 362663005187 ABC transporter signature motif; other site 362663005188 Walker B; other site 362663005189 D-loop; other site 362663005190 H-loop/switch region; other site 362663005191 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 362663005192 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 362663005193 active site residue [active] 362663005194 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 362663005195 active site residue [active] 362663005196 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 362663005197 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 362663005198 active site 362663005199 8-oxo-dGMP binding site [chemical binding]; other site 362663005200 nudix motif; other site 362663005201 metal binding site [ion binding]; metal-binding site 362663005202 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 362663005203 glutamate dehydrogenase; Provisional; Region: PRK09414 362663005204 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 362663005205 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 362663005206 NAD(P) binding site [chemical binding]; other site 362663005207 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 362663005208 HSP70 interaction site [polypeptide binding]; other site 362663005209 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 362663005210 Sel1-like repeats; Region: SEL1; smart00671 362663005211 Sel1-like repeats; Region: SEL1; smart00671 362663005212 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 362663005213 Sel1-like repeats; Region: SEL1; smart00671 362663005214 Sel1-like repeats; Region: SEL1; smart00671 362663005215 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 362663005216 HSP70 interaction site [polypeptide binding]; other site 362663005217 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 362663005218 Sel1-like repeats; Region: SEL1; smart00671 362663005219 Sel1-like repeats; Region: SEL1; smart00671 362663005220 Sel1-like repeats; Region: SEL1; smart00671 362663005221 Sel1-like repeats; Region: SEL1; smart00671 362663005222 Sel1-like repeats; Region: SEL1; smart00671 362663005223 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 362663005224 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 362663005225 nucleotide binding site [chemical binding]; other site 362663005226 putative NEF/HSP70 interaction site [polypeptide binding]; other site 362663005227 SBD interface [polypeptide binding]; other site 362663005228 DNA topoisomerase III; Provisional; Region: PRK07726 362663005229 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 362663005230 active site 362663005231 putative interdomain interaction site [polypeptide binding]; other site 362663005232 putative metal-binding site [ion binding]; other site 362663005233 putative nucleotide binding site [chemical binding]; other site 362663005234 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 362663005235 domain I; other site 362663005236 DNA binding groove [nucleotide binding] 362663005237 phosphate binding site [ion binding]; other site 362663005238 domain II; other site 362663005239 domain III; other site 362663005240 nucleotide binding site [chemical binding]; other site 362663005241 catalytic site [active] 362663005242 domain IV; other site 362663005243 selenophosphate synthetase; Provisional; Region: PRK00943 362663005244 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 362663005245 dimerization interface [polypeptide binding]; other site 362663005246 putative ATP binding site [chemical binding]; other site 362663005247 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 362663005248 putative FMN binding site [chemical binding]; other site 362663005249 protease 4; Provisional; Region: PRK10949 362663005250 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 362663005251 tandem repeat interface [polypeptide binding]; other site 362663005252 oligomer interface [polypeptide binding]; other site 362663005253 active site residues [active] 362663005254 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 362663005255 tandem repeat interface [polypeptide binding]; other site 362663005256 oligomer interface [polypeptide binding]; other site 362663005257 active site residues [active] 362663005258 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 362663005259 active site 362663005260 homodimer interface [polypeptide binding]; other site 362663005261 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 362663005262 Isochorismatase family; Region: Isochorismatase; pfam00857 362663005263 catalytic triad [active] 362663005264 metal binding site [ion binding]; metal-binding site 362663005265 conserved cis-peptide bond; other site 362663005266 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 362663005267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005268 putative substrate translocation pore; other site 362663005269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005270 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663005271 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663005272 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663005273 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663005274 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663005275 active site 362663005276 catalytic tetrad [active] 362663005277 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663005278 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 362663005279 substrate binding site [chemical binding]; other site 362663005280 ATP binding site [chemical binding]; other site 362663005281 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362663005282 intersubunit interface [polypeptide binding]; other site 362663005283 active site 362663005284 zinc binding site [ion binding]; other site 362663005285 Na+ binding site [ion binding]; other site 362663005286 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663005287 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 362663005288 inhibitor binding site; inhibition site 362663005289 catalytic Zn binding site [ion binding]; other site 362663005290 structural Zn binding site [ion binding]; other site 362663005291 NADP binding site [chemical binding]; other site 362663005292 tetramer interface [polypeptide binding]; other site 362663005293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005295 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663005296 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 362663005297 putative NAD(P) binding site [chemical binding]; other site 362663005298 catalytic Zn binding site [ion binding]; other site 362663005299 structural Zn binding site [ion binding]; other site 362663005300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 362663005301 methionine sulfoxide reductase B; Provisional; Region: PRK00222 362663005302 SelR domain; Region: SelR; pfam01641 362663005303 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 362663005304 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 362663005305 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 362663005306 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 362663005307 active site 362663005308 phosphate binding residues; other site 362663005309 catalytic residues [active] 362663005310 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663005311 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663005312 active site 362663005313 catalytic tetrad [active] 362663005314 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 362663005315 PrkA family serine protein kinase; Provisional; Region: PRK15455 362663005316 AAA ATPase domain; Region: AAA_16; pfam13191 362663005317 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 362663005318 hypothetical protein; Provisional; Region: PRK05325 362663005319 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663005320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663005321 metal binding site [ion binding]; metal-binding site 362663005322 active site 362663005323 I-site; other site 362663005324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663005325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663005326 metal binding site [ion binding]; metal-binding site 362663005327 active site 362663005328 I-site; other site 362663005329 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 362663005330 putative deacylase active site [active] 362663005331 Predicted membrane protein [Function unknown]; Region: COG2707 362663005332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663005333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663005334 cyanate transporter; Region: CynX; TIGR00896 362663005335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005336 Uncharacterized conserved protein [Function unknown]; Region: COG3189 362663005337 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 362663005338 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 362663005339 Domain of unknown function (DUF333); Region: DUF333; pfam03891 362663005340 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 362663005341 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 362663005342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663005343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663005344 metal binding site [ion binding]; metal-binding site 362663005345 active site 362663005346 I-site; other site 362663005347 hypothetical protein; Provisional; Region: PRK10457 362663005348 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 362663005349 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 362663005350 leucine export protein LeuE; Provisional; Region: PRK10958 362663005351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663005352 ribonuclease D; Provisional; Region: PRK10829 362663005353 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 362663005354 catalytic site [active] 362663005355 putative active site [active] 362663005356 putative substrate binding site [chemical binding]; other site 362663005357 Helicase and RNase D C-terminal; Region: HRDC; smart00341 362663005358 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 362663005359 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 362663005360 acyl-activating enzyme (AAE) consensus motif; other site 362663005361 putative AMP binding site [chemical binding]; other site 362663005362 putative active site [active] 362663005363 putative CoA binding site [chemical binding]; other site 362663005364 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 362663005365 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 362663005366 Glycoprotease family; Region: Peptidase_M22; pfam00814 362663005367 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 362663005368 DEAD/DEAH box helicase; Region: DEAD; pfam00270 362663005369 DEAD_2; Region: DEAD_2; pfam06733 362663005370 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 362663005371 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 362663005372 homotrimer interaction site [polypeptide binding]; other site 362663005373 putative active site [active] 362663005374 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 362663005375 hypothetical protein; Provisional; Region: PRK05114 362663005376 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 362663005377 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 362663005378 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 362663005379 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 362663005380 putative active site [active] 362663005381 putative CoA binding site [chemical binding]; other site 362663005382 nudix motif; other site 362663005383 metal binding site [ion binding]; metal-binding site 362663005384 L-serine deaminase; Provisional; Region: PRK15023 362663005385 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 362663005386 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 362663005387 phage resistance protein; Provisional; Region: PRK10551 362663005388 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 362663005389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663005390 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 362663005391 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 362663005392 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362663005393 Transporter associated domain; Region: CorC_HlyC; smart01091 362663005394 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 362663005395 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362663005396 active pocket/dimerization site; other site 362663005397 active site 362663005398 phosphorylation site [posttranslational modification] 362663005399 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362663005400 active site 362663005401 phosphorylation site [posttranslational modification] 362663005402 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 362663005403 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 362663005404 Predicted membrane protein [Function unknown]; Region: COG4811 362663005405 hypothetical protein; Provisional; Region: PRK11469 362663005406 Domain of unknown function DUF; Region: DUF204; pfam02659 362663005407 Domain of unknown function DUF; Region: DUF204; pfam02659 362663005408 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 362663005409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005410 S-adenosylmethionine binding site [chemical binding]; other site 362663005411 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663005412 DNA-binding site [nucleotide binding]; DNA binding site 362663005413 RNA-binding motif; other site 362663005414 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 362663005415 YebO-like protein; Region: YebO; pfam13974 362663005416 YobH-like protein; Region: YobH; pfam13996 362663005417 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 362663005418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663005419 dimerization interface [polypeptide binding]; other site 362663005420 putative Zn2+ binding site [ion binding]; other site 362663005421 putative DNA binding site [nucleotide binding]; other site 362663005422 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663005423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663005425 putative substrate translocation pore; other site 362663005426 Predicted integral membrane protein [Function unknown]; Region: COG5521 362663005427 heat shock protein HtpX; Provisional; Region: PRK05457 362663005428 carboxy-terminal protease; Provisional; Region: PRK11186 362663005429 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 362663005430 protein binding site [polypeptide binding]; other site 362663005431 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 362663005432 Catalytic dyad [active] 362663005433 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 362663005434 ProP expression regulator; Provisional; Region: PRK04950 362663005435 ProQ/FINO family; Region: ProQ; pfam04352 362663005436 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 362663005437 GAF domain; Region: GAF_2; pfam13185 362663005438 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 362663005439 Paraquat-inducible protein A; Region: PqiA; pfam04403 362663005440 Paraquat-inducible protein A; Region: PqiA; pfam04403 362663005441 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 362663005442 mce related protein; Region: MCE; pfam02470 362663005443 mce related protein; Region: MCE; pfam02470 362663005444 mce related protein; Region: MCE; pfam02470 362663005445 mce related protein; Region: MCE; pfam02470 362663005446 mce related protein; Region: MCE; pfam02470 362663005447 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 362663005448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005449 S-adenosylmethionine binding site [chemical binding]; other site 362663005450 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 362663005451 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 362663005452 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 362663005453 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 362663005454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 362663005455 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 362663005456 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 362663005457 hypothetical protein; Provisional; Region: PRK10301 362663005458 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 362663005459 Predicted amidohydrolase [General function prediction only]; Region: COG0388 362663005460 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 362663005461 exodeoxyribonuclease X; Provisional; Region: PRK07983 362663005462 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 362663005463 active site 362663005464 catalytic site [active] 362663005465 substrate binding site [chemical binding]; other site 362663005466 protease 2; Provisional; Region: PRK10115 362663005467 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 362663005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 362663005469 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 362663005470 putative metal binding site [ion binding]; other site 362663005471 hypothetical protein; Provisional; Region: PRK13680 362663005472 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 362663005473 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 362663005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362663005475 ATP-grasp domain; Region: ATP-grasp; pfam02222 362663005476 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 362663005477 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 362663005478 active site 362663005479 intersubunit interface [polypeptide binding]; other site 362663005480 catalytic residue [active] 362663005481 phosphogluconate dehydratase; Validated; Region: PRK09054 362663005482 6-phosphogluconate dehydratase; Region: edd; TIGR01196 362663005483 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 362663005484 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 362663005485 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 362663005486 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 362663005487 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362663005488 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362663005489 putative active site [active] 362663005490 pyruvate kinase; Provisional; Region: PRK05826 362663005491 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 362663005492 domain interfaces; other site 362663005493 active site 362663005494 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 362663005495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 362663005496 putative acyl-acceptor binding pocket; other site 362663005497 putative peptidase; Provisional; Region: PRK11649 362663005498 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 362663005499 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663005500 Peptidase family M23; Region: Peptidase_M23; pfam01551 362663005501 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 362663005502 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 362663005503 metal binding site [ion binding]; metal-binding site 362663005504 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 362663005505 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 362663005506 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362663005507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663005508 ABC-ATPase subunit interface; other site 362663005509 dimer interface [polypeptide binding]; other site 362663005510 putative PBP binding regions; other site 362663005511 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 362663005512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663005513 Walker A motif; other site 362663005514 ATP binding site [chemical binding]; other site 362663005515 Walker B motif; other site 362663005516 arginine finger; other site 362663005517 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 362663005518 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 362663005519 RuvA N terminal domain; Region: RuvA_N; pfam01330 362663005520 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 362663005521 hypothetical protein; Provisional; Region: PRK11470 362663005522 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 362663005523 active site 362663005524 putative DNA-binding cleft [nucleotide binding]; other site 362663005525 dimer interface [polypeptide binding]; other site 362663005526 hypothetical protein; Validated; Region: PRK00110 362663005527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 362663005528 nudix motif; other site 362663005529 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 362663005530 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 362663005531 dimer interface [polypeptide binding]; other site 362663005532 anticodon binding site; other site 362663005533 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 362663005534 homodimer interface [polypeptide binding]; other site 362663005535 motif 1; other site 362663005536 active site 362663005537 motif 2; other site 362663005538 GAD domain; Region: GAD; pfam02938 362663005539 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 362663005540 motif 3; other site 362663005541 Isochorismatase family; Region: Isochorismatase; pfam00857 362663005542 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 362663005543 catalytic triad [active] 362663005544 conserved cis-peptide bond; other site 362663005545 hypothetical protein; Provisional; Region: PRK10302 362663005546 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 362663005547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005548 S-adenosylmethionine binding site [chemical binding]; other site 362663005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005550 S-adenosylmethionine binding site [chemical binding]; other site 362663005551 trimethylamine-N-oxide reductase 2 precursor nonfunction due to the frame shift 362663005552 trimethylamine-N-oxide reductase 2 precursor nonfunction due to the frame shift 362663005553 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 362663005554 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 362663005555 copper homeostasis protein CutC; Provisional; Region: PRK11572 362663005556 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 362663005557 putative metal binding site [ion binding]; other site 362663005558 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 362663005559 arginyl-tRNA synthetase; Region: argS; TIGR00456 362663005560 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 362663005561 active site 362663005562 HIGH motif; other site 362663005563 KMSK motif region; other site 362663005564 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 362663005565 tRNA binding surface [nucleotide binding]; other site 362663005566 anticodon binding site; other site 362663005567 Flagellar protein FlhE; Region: FlhE; pfam06366 362663005568 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 362663005569 FHIPEP family; Region: FHIPEP; pfam00771 362663005570 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 362663005571 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 362663005572 chemotaxis regulator CheZ; Provisional; Region: PRK11166 362663005573 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 362663005574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663005575 active site 362663005576 phosphorylation site [posttranslational modification] 362663005577 intermolecular recognition site; other site 362663005578 dimerization interface [polypeptide binding]; other site 362663005579 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 362663005580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663005581 active site 362663005582 phosphorylation site [posttranslational modification] 362663005583 intermolecular recognition site; other site 362663005584 dimerization interface [polypeptide binding]; other site 362663005585 CheB methylesterase; Region: CheB_methylest; pfam01339 362663005586 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 362663005587 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 362663005588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005589 S-adenosylmethionine binding site [chemical binding]; other site 362663005590 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 362663005591 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 362663005592 dimer interface [polypeptide binding]; other site 362663005593 ligand binding site [chemical binding]; other site 362663005594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663005595 dimerization interface [polypeptide binding]; other site 362663005596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 362663005597 dimer interface [polypeptide binding]; other site 362663005598 putative CheW interface [polypeptide binding]; other site 362663005599 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 362663005600 putative CheA interaction surface; other site 362663005601 chemotaxis protein CheA; Provisional; Region: PRK10547 362663005602 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663005603 putative binding surface; other site 362663005604 active site 362663005605 CheY binding; Region: CheY-binding; pfam09078 362663005606 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 362663005607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663005608 ATP binding site [chemical binding]; other site 362663005609 Mg2+ binding site [ion binding]; other site 362663005610 G-X-G motif; other site 362663005611 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 362663005612 flagellar motor protein MotB; Validated; Region: motB; PRK09041 362663005613 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 362663005614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663005615 ligand binding site [chemical binding]; other site 362663005616 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 362663005617 flagellar motor protein MotA; Validated; Region: PRK09110 362663005618 transcriptional activator FlhC; Provisional; Region: PRK12722 362663005619 transcriptional activator FlhD; Provisional; Region: PRK02909 362663005620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663005621 Ligand Binding Site [chemical binding]; other site 362663005622 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 362663005623 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 362663005624 active site 362663005625 homotetramer interface [polypeptide binding]; other site 362663005626 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 362663005627 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 362663005628 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663005629 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663005630 TM-ABC transporter signature motif; other site 362663005631 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 362663005632 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663005633 Walker A/P-loop; other site 362663005634 ATP binding site [chemical binding]; other site 362663005635 Q-loop/lid; other site 362663005636 ABC transporter signature motif; other site 362663005637 Walker B; other site 362663005638 D-loop; other site 362663005639 H-loop/switch region; other site 362663005640 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663005641 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 362663005642 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 362663005643 ligand binding site [chemical binding]; other site 362663005644 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 362663005645 Ferritin-like domain; Region: Ferritin; pfam00210 362663005646 ferroxidase diiron center [ion binding]; other site 362663005647 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 362663005648 YecR-like lipoprotein; Region: YecR; pfam13992 362663005649 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 362663005650 Ferritin-like domain; Region: Ferritin; pfam00210 362663005651 ferroxidase diiron center [ion binding]; other site 362663005652 probable metal-binding protein; Region: matur_matur; TIGR03853 362663005653 tyrosine transporter TyrP; Provisional; Region: PRK15132 362663005654 aromatic amino acid transport protein; Region: araaP; TIGR00837 362663005655 hypothetical protein; Provisional; Region: PRK10396 362663005656 yecA family protein; Region: ygfB_yecA; TIGR02292 362663005657 SEC-C motif; Region: SEC-C; pfam02810 362663005658 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 362663005659 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 362663005660 UvrB/uvrC motif; Region: UVR; pfam02151 362663005661 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 362663005662 Helix-hairpin-helix motif; Region: HHH; pfam00633 362663005663 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 362663005664 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 362663005665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362663005666 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 362663005667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362663005668 DNA binding residues [nucleotide binding] 362663005669 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 362663005670 flagellin; Validated; Region: PRK08026 362663005671 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 362663005672 Flagellin protein; Region: FliC; pfam12445 362663005673 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 362663005674 flagellar capping protein; Reviewed; Region: fliD; PRK08032 362663005675 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 362663005676 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 362663005677 Flagellar protein FliS; Region: FliS; cl00654 362663005678 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 362663005679 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 362663005680 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 362663005681 active site 362663005682 Na/Ca binding site [ion binding]; other site 362663005683 catalytic site [active] 362663005684 lipoprotein; Provisional; Region: PRK10397 362663005685 putative inner membrane protein; Provisional; Region: PRK11099 362663005686 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 362663005687 CPxP motif; other site 362663005688 hypothetical protein; Provisional; Region: PRK09951 362663005689 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663005690 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663005691 trimer interface [polypeptide binding]; other site 362663005692 eyelet of channel; other site 362663005693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663005694 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 362663005695 substrate binding site [chemical binding]; other site 362663005696 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 362663005697 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 362663005698 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 362663005699 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 362663005700 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 362663005701 flagellar motor switch protein FliG; Region: fliG; TIGR00207 362663005702 FliG C-terminal domain; Region: FliG_C; pfam01706 362663005703 flagellar assembly protein H; Validated; Region: fliH; PRK05687 362663005704 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 362663005705 Flagellar assembly protein FliH; Region: FliH; pfam02108 362663005706 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 362663005707 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 362663005708 Walker A motif/ATP binding site; other site 362663005709 Walker B motif; other site 362663005710 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 362663005711 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 362663005712 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 362663005713 flagellar hook-length control protein; Provisional; Region: PRK10118 362663005714 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 362663005715 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 362663005716 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 362663005717 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 362663005718 flagellar motor switch protein; Validated; Region: fliN; PRK05698 362663005719 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 362663005720 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 362663005721 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 362663005722 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 362663005723 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 362663005724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663005725 DNA binding residues [nucleotide binding] 362663005726 dimerization interface [polypeptide binding]; other site 362663005727 hypothetical protein; Provisional; Region: PRK10708 362663005728 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 362663005729 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 362663005730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663005731 active site 362663005732 motif I; other site 362663005733 motif II; other site 362663005734 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 362663005735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663005736 metal binding site [ion binding]; metal-binding site 362663005737 active site 362663005738 I-site; other site 362663005739 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 362663005740 hypothetical protein; Provisional; Region: PRK10062 362663005741 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 362663005742 EamA-like transporter family; Region: EamA; pfam00892 362663005743 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 362663005744 additional DNA contacts [nucleotide binding]; other site 362663005745 mismatch recognition site; other site 362663005746 active site 362663005747 zinc binding site [ion binding]; other site 362663005748 DNA intercalation site [nucleotide binding]; other site 362663005749 DNA cytosine methylase; Provisional; Region: PRK10458 362663005750 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 362663005751 cofactor binding site; other site 362663005752 DNA binding site [nucleotide binding] 362663005753 substrate interaction site [chemical binding]; other site 362663005754 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 362663005755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362663005756 Zn2+ binding site [ion binding]; other site 362663005757 Mg2+ binding site [ion binding]; other site 362663005758 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 362663005759 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663005760 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663005761 trimer interface [polypeptide binding]; other site 362663005762 eyelet of channel; other site 362663005763 chaperone protein HchA; Provisional; Region: PRK04155 362663005764 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 362663005765 dimer interface [polypeptide binding]; other site 362663005766 metal binding site [ion binding]; metal-binding site 362663005767 potential oxyanion hole; other site 362663005768 potential catalytic triad [active] 362663005769 conserved cys residue [active] 362663005770 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 362663005771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663005772 dimer interface [polypeptide binding]; other site 362663005773 phosphorylation site [posttranslational modification] 362663005774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663005775 ATP binding site [chemical binding]; other site 362663005776 Mg2+ binding site [ion binding]; other site 362663005777 G-X-G motif; other site 362663005778 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 362663005779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663005780 active site 362663005781 phosphorylation site [posttranslational modification] 362663005782 intermolecular recognition site; other site 362663005783 dimerization interface [polypeptide binding]; other site 362663005784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663005785 DNA binding site [nucleotide binding] 362663005786 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 362663005787 active site 362663005788 homotetramer interface [polypeptide binding]; other site 362663005789 TMAO/DMSO reductase; Reviewed; Region: PRK05363 362663005790 TMAO/DMSO reductase; Reviewed; Region: PRK05363 362663005791 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 362663005792 Moco binding site; other site 362663005793 metal coordination site [ion binding]; other site 362663005794 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 362663005795 zinc/cadmium-binding protein; Provisional; Region: PRK10306 362663005796 integrase; Provisional; Region: PRK09692 362663005797 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663005798 active site 362663005799 Int/Topo IB signature motif; other site 362663005800 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 362663005801 PilS N terminal; Region: PilS; pfam08805 362663005802 Conjugal transfer protein TraD; Region: TraD; pfam06412 362663005803 MobA/MobL family; Region: MobA_MobL; pfam03389 362663005804 TIR domain; Region: TIR_2; pfam13676 362663005805 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 362663005806 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 362663005807 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 362663005808 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 362663005809 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 362663005810 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 362663005811 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 362663005812 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663005813 active site 362663005814 Int/Topo IB signature motif; other site 362663005815 salicylate synthase Irp9; Reviewed; Region: PRK06772 362663005816 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 362663005817 muropeptide transporter; Validated; Region: ampG; cl17669 362663005818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362663005819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663005820 Walker A/P-loop; other site 362663005821 ATP binding site [chemical binding]; other site 362663005822 Q-loop/lid; other site 362663005823 ABC transporter signature motif; other site 362663005824 Walker B; other site 362663005825 D-loop; other site 362663005826 H-loop/switch region; other site 362663005827 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663005828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 362663005829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663005830 Walker A/P-loop; other site 362663005831 ATP binding site [chemical binding]; other site 362663005832 Q-loop/lid; other site 362663005833 ABC transporter signature motif; other site 362663005834 Walker B; other site 362663005835 D-loop; other site 362663005836 H-loop/switch region; other site 362663005837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663005838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663005839 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 362663005840 Condensation domain; Region: Condensation; pfam00668 362663005841 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005842 Nonribosomal peptide synthase; Region: NRPS; pfam08415 362663005843 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 362663005844 acyl-activating enzyme (AAE) consensus motif; other site 362663005845 AMP binding site [chemical binding]; other site 362663005846 Methyltransferase domain; Region: Methyltransf_23; pfam13489 362663005847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663005848 S-adenosylmethionine binding site [chemical binding]; other site 362663005849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 362663005850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005851 Condensation domain; Region: Condensation; pfam00668 362663005852 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005853 Nonribosomal peptide synthase; Region: NRPS; pfam08415 362663005854 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005855 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663005856 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663005857 active site 362663005858 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 362663005859 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 362663005860 Methyltransferase domain; Region: Methyltransf_12; pfam08242 362663005861 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 362663005862 KR domain; Region: KR; pfam08659 362663005863 NADP binding site [chemical binding]; other site 362663005864 active site 362663005865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005866 Condensation domain; Region: Condensation; pfam00668 362663005867 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005868 Nonribosomal peptide synthase; Region: NRPS; pfam08415 362663005869 Methyltransferase domain; Region: Methyltransf_12; pfam08242 362663005870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005871 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 362663005872 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 362663005873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663005874 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 362663005875 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 362663005876 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 362663005877 acyl-activating enzyme (AAE) consensus motif; other site 362663005878 active site 362663005879 AMP binding site [chemical binding]; other site 362663005880 substrate binding site [chemical binding]; other site 362663005881 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 362663005882 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663005883 N-terminal plug; other site 362663005884 ligand-binding site [chemical binding]; other site 362663005885 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 362663005886 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 362663005887 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 362663005888 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 362663005889 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 362663005890 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 362663005891 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 362663005892 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362663005893 shikimate transporter; Provisional; Region: PRK09952 362663005894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663005895 putative substrate translocation pore; other site 362663005896 AMP nucleosidase; Provisional; Region: PRK08292 362663005897 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 362663005898 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 362663005899 hypothetical protein; Provisional; Region: PRK12378 362663005900 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 362663005901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663005902 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 362663005903 putative dimerization interface [polypeptide binding]; other site 362663005904 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 362663005905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663005906 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 362663005907 putative substrate binding site [chemical binding]; other site 362663005908 dimerization interface [polypeptide binding]; other site 362663005909 MATE family multidrug exporter; Provisional; Region: PRK10189 362663005910 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 362663005911 integrase; Provisional; Region: PRK09692 362663005912 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663005913 active site 362663005914 Int/Topo IB signature motif; other site 362663005915 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 362663005916 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 362663005917 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 362663005918 Beta-lactamase; Region: Beta-lactamase; pfam00144 362663005919 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663005920 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663005921 active site 362663005922 Condensation domain; Region: Condensation; pfam00668 362663005923 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 362663005924 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 362663005925 acyl-activating enzyme (AAE) consensus motif; other site 362663005926 AMP binding site [chemical binding]; other site 362663005927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005928 Condensation domain; Region: Condensation; pfam00668 362663005929 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 362663005930 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 362663005931 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 362663005932 amidase; Provisional; Region: PRK06170 362663005933 Amidase; Region: Amidase; cl11426 362663005934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663005935 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663005936 active site 362663005937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005938 Condensation domain; Region: Condensation; pfam00668 362663005939 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005940 Nonribosomal peptide synthase; Region: NRPS; pfam08415 362663005941 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 362663005942 acyl-activating enzyme (AAE) consensus motif; other site 362663005943 AMP binding site [chemical binding]; other site 362663005944 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 362663005945 putative FMN binding site [chemical binding]; other site 362663005946 NADPH bind site [chemical binding]; other site 362663005947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 362663005948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005949 Condensation domain; Region: Condensation; pfam00668 362663005950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 362663005952 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 362663005953 acyl-activating enzyme (AAE) consensus motif; other site 362663005954 AMP binding site [chemical binding]; other site 362663005955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005956 Condensation domain; Region: Condensation; pfam00668 362663005957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005958 Nonribosomal peptide synthase; Region: NRPS; pfam08415 362663005959 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 362663005960 acyl-activating enzyme (AAE) consensus motif; other site 362663005961 AMP binding site [chemical binding]; other site 362663005962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005963 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663005964 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663005965 active site 362663005966 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 362663005967 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 362663005968 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005969 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 362663005970 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 362663005971 acyl-activating enzyme (AAE) consensus motif; other site 362663005972 AMP binding site [chemical binding]; other site 362663005973 Condensation domain; Region: Condensation; pfam00668 362663005974 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005975 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 362663005976 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 362663005977 acyl-activating enzyme (AAE) consensus motif; other site 362663005978 AMP binding site [chemical binding]; other site 362663005979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005980 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 362663005981 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 362663005982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 362663005983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 362663005984 active site 362663005985 acyl carrier protein; Provisional; Region: PRK07081 362663005986 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 362663005987 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 362663005988 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 362663005989 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663005990 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663005991 active site 362663005992 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005993 Condensation domain; Region: Condensation; pfam00668 362663005994 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 362663005995 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 362663005996 acyl-activating enzyme (AAE) consensus motif; other site 362663005997 AMP binding site [chemical binding]; other site 362663005998 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663005999 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 362663006000 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 362663006001 active site 362663006002 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 362663006003 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 362663006004 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 362663006005 KR domain; Region: KR; pfam08659 362663006006 putative NADP binding site [chemical binding]; other site 362663006007 active site 362663006008 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 362663006009 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 362663006010 Enoylreductase; Region: PKS_ER; smart00829 362663006011 NAD(P) binding site [chemical binding]; other site 362663006012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663006013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663006014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663006015 DNA binding residues [nucleotide binding] 362663006016 dimerization interface [polypeptide binding]; other site 362663006017 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 362663006018 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663006019 DNA-binding interface [nucleotide binding]; DNA binding site 362663006020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 362663006021 Integrase core domain; Region: rve; pfam00665 362663006022 Integrase core domain; Region: rve_3; pfam13683 362663006023 Integrase core domain; Region: rve_2; pfam13333 362663006024 L,D-transpeptidase; Provisional; Region: PRK10190 362663006025 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 362663006026 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 362663006027 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 362663006028 putative dimer interface [polypeptide binding]; other site 362663006029 active site pocket [active] 362663006030 putative cataytic base [active] 362663006031 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 362663006032 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 362663006033 homotrimer interface [polypeptide binding]; other site 362663006034 Walker A motif; other site 362663006035 GTP binding site [chemical binding]; other site 362663006036 Walker B motif; other site 362663006037 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 362663006038 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663006039 N-terminal plug; other site 362663006040 ligand-binding site [chemical binding]; other site 362663006041 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 362663006042 ParB-like nuclease domain; Region: ParBc; cl02129 362663006043 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 362663006044 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 362663006045 Active Sites [active] 362663006046 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 362663006047 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 362663006048 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 362663006049 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 362663006050 DXD motif; other site 362663006051 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 362663006052 putative trimer interface [polypeptide binding]; other site 362663006053 putative CoA binding site [chemical binding]; other site 362663006054 Predicted GTPase [General function prediction only]; Region: COG3596 362663006055 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 362663006056 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663006057 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663006058 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663006059 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 362663006060 substrate binding site [chemical binding]; other site 362663006061 dimer interface [polypeptide binding]; other site 362663006062 ATP binding site [chemical binding]; other site 362663006063 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 362663006064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 362663006065 Protein of unknown function, DUF606; Region: DUF606; pfam04657 362663006066 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 362663006067 active site 362663006068 substrate binding pocket [chemical binding]; other site 362663006069 homodimer interaction site [polypeptide binding]; other site 362663006070 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 362663006071 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 362663006072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362663006073 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362663006074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 362663006075 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362663006076 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 362663006077 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 362663006078 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 362663006079 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 362663006080 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663006081 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663006082 Transposase; Region: DEDD_Tnp_IS110; pfam01548 362663006083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663006084 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663006085 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 362663006086 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 362663006087 transposase/IS protein; Provisional; Region: PRK09183 362663006088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663006089 Walker A motif; other site 362663006090 ATP binding site [chemical binding]; other site 362663006091 Walker B motif; other site 362663006092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663006093 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663006094 DNA-binding interface [nucleotide binding]; DNA binding site 362663006095 Integrase core domain; Region: rve; pfam00665 362663006096 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 362663006097 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663006098 Walker A/P-loop; other site 362663006099 ATP binding site [chemical binding]; other site 362663006100 Q-loop/lid; other site 362663006101 ABC transporter signature motif; other site 362663006102 Walker B; other site 362663006103 D-loop; other site 362663006104 H-loop/switch region; other site 362663006105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663006106 dimer interface [polypeptide binding]; other site 362663006107 putative PBP binding regions; other site 362663006108 ABC-ATPase subunit interface; other site 362663006109 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 362663006110 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 362663006111 putative ligand binding residues [chemical binding]; other site 362663006112 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 362663006113 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663006114 N-terminal plug; other site 362663006115 ligand-binding site [chemical binding]; other site 362663006116 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362663006117 G1 box; other site 362663006118 GTP/Mg2+ binding site [chemical binding]; other site 362663006119 G2 box; other site 362663006120 Switch I region; other site 362663006121 Switch II region; other site 362663006122 hypothetical protein; Provisional; Region: PRK09866 362663006123 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362663006124 G1 box; other site 362663006125 GTP/Mg2+ binding site [chemical binding]; other site 362663006126 G2 box; other site 362663006127 Switch I region; other site 362663006128 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362663006129 G3 box; other site 362663006130 Switch II region; other site 362663006131 GTP/Mg2+ binding site [chemical binding]; other site 362663006132 G4 box; other site 362663006133 G5 box; other site 362663006134 YjcZ-like protein; Region: YjcZ; pfam13990 362663006135 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 362663006136 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 362663006137 nucleophile elbow; other site 362663006138 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 362663006139 Domain of unknown function (DUF932); Region: DUF932; pfam06067 362663006140 Antirestriction protein; Region: Antirestrict; pfam03230 362663006141 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 362663006142 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663006143 MPN+ (JAMM) motif; other site 362663006144 Zinc-binding site [ion binding]; other site 362663006145 Protein of unknown function (DUF987); Region: DUF987; pfam06174 362663006146 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 362663006147 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 362663006148 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 362663006149 Switch II region; other site 362663006150 G4 box; other site 362663006151 G5 box; other site 362663006152 hypothetical protein; Provisional; Region: PRK05423 362663006153 Predicted membrane protein [Function unknown]; Region: COG1289 362663006154 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663006155 DNA gyrase inhibitor; Provisional; Region: PRK10016 362663006156 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 362663006157 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 362663006158 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 362663006159 exonuclease I; Provisional; Region: sbcB; PRK11779 362663006160 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 362663006161 active site 362663006162 catalytic site [active] 362663006163 substrate binding site [chemical binding]; other site 362663006164 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 362663006165 amino acid transporter; Region: 2A0306; TIGR00909 362663006166 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 362663006167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663006168 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 362663006169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663006170 dimerization interface [polypeptide binding]; other site 362663006171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362663006172 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 362663006173 putative NAD(P) binding site [chemical binding]; other site 362663006174 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 362663006175 antitoxin YefM; Provisional; Region: PRK11409 362663006176 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 362663006177 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 362663006178 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 362663006179 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 362663006180 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 362663006181 NAD binding site [chemical binding]; other site 362663006182 dimerization interface [polypeptide binding]; other site 362663006183 product binding site; other site 362663006184 substrate binding site [chemical binding]; other site 362663006185 zinc binding site [ion binding]; other site 362663006186 catalytic residues [active] 362663006187 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 362663006188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663006189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663006190 homodimer interface [polypeptide binding]; other site 362663006191 catalytic residue [active] 362663006192 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 362663006193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663006194 active site 362663006195 motif I; other site 362663006196 motif II; other site 362663006197 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 362663006198 putative active site pocket [active] 362663006199 4-fold oligomerization interface [polypeptide binding]; other site 362663006200 metal binding residues [ion binding]; metal-binding site 362663006201 3-fold/trimer interface [polypeptide binding]; other site 362663006202 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 362663006203 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 362663006204 putative active site [active] 362663006205 oxyanion strand; other site 362663006206 catalytic triad [active] 362663006207 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 362663006208 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 362663006209 catalytic residues [active] 362663006210 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 362663006211 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 362663006212 substrate binding site [chemical binding]; other site 362663006213 glutamase interaction surface [polypeptide binding]; other site 362663006214 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 362663006215 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 362663006216 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 362663006217 metal binding site [ion binding]; metal-binding site 362663006218 chain length determinant protein WzzB; Provisional; Region: PRK15471 362663006219 Chain length determinant protein; Region: Wzz; pfam02706 362663006220 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 362663006221 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 362663006222 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 362663006223 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 362663006224 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 362663006225 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 362663006226 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 362663006227 phosphomannomutase CpsG; Provisional; Region: PRK15414 362663006228 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 362663006229 active site 362663006230 substrate binding site [chemical binding]; other site 362663006231 metal binding site [ion binding]; metal-binding site 362663006232 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 362663006233 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 362663006234 Substrate binding site; other site 362663006235 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 362663006236 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 362663006237 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 362663006238 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 362663006239 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 362663006240 NAD binding site [chemical binding]; other site 362663006241 homodimer interface [polypeptide binding]; other site 362663006242 active site 362663006243 substrate binding site [chemical binding]; other site 362663006244 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 362663006245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362663006246 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 362663006247 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362663006248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362663006249 active site 362663006250 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 362663006251 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 362663006252 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 362663006253 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 362663006254 active site 362663006255 tetramer interface; other site 362663006256 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 362663006257 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 362663006258 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 362663006259 putative ADP-binding pocket [chemical binding]; other site 362663006260 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 362663006261 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 362663006262 colanic acid exporter; Provisional; Region: PRK10459 362663006263 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 362663006264 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 362663006265 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 362663006266 phosphomannomutase CpsG; Provisional; Region: PRK15414 362663006267 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 362663006268 active site 362663006269 substrate binding site [chemical binding]; other site 362663006270 metal binding site [ion binding]; metal-binding site 362663006271 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 362663006272 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 362663006273 Substrate binding site; other site 362663006274 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 362663006275 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 362663006276 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 362663006277 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 362663006278 active site 362663006279 GDP-Mannose binding site [chemical binding]; other site 362663006280 dimer interface [polypeptide binding]; other site 362663006281 modified nudix motif 362663006282 metal binding site [ion binding]; metal-binding site 362663006283 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 362663006284 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 362663006285 NADP binding site [chemical binding]; other site 362663006286 active site 362663006287 putative substrate binding site [chemical binding]; other site 362663006288 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 362663006289 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 362663006290 NADP-binding site; other site 362663006291 homotetramer interface [polypeptide binding]; other site 362663006292 substrate binding site [chemical binding]; other site 362663006293 homodimer interface [polypeptide binding]; other site 362663006294 active site 362663006295 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 362663006296 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 362663006297 putative trimer interface [polypeptide binding]; other site 362663006298 putative active site [active] 362663006299 putative substrate binding site [chemical binding]; other site 362663006300 putative CoA binding site [chemical binding]; other site 362663006301 putative glycosyl transferase; Provisional; Region: PRK10063 362663006302 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 362663006303 metal-binding site 362663006304 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 362663006305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362663006306 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 362663006307 putative acyl transferase; Provisional; Region: PRK10191 362663006308 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 362663006309 trimer interface [polypeptide binding]; other site 362663006310 active site 362663006311 substrate binding site [chemical binding]; other site 362663006312 CoA binding site [chemical binding]; other site 362663006313 putative glycosyl transferase; Provisional; Region: PRK10018 362663006314 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 362663006315 active site 362663006316 tyrosine kinase; Provisional; Region: PRK11519 362663006317 Chain length determinant protein; Region: Wzz; pfam02706 362663006318 Chain length determinant protein; Region: Wzz; cl15801 362663006319 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 362663006320 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 362663006321 Low molecular weight phosphatase family; Region: LMWPc; cd00115 362663006322 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 362663006323 active site 362663006324 polysaccharide export protein Wza; Provisional; Region: PRK15078 362663006325 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 362663006326 SLBB domain; Region: SLBB; pfam10531 362663006327 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 362663006328 FOG: CBS domain [General function prediction only]; Region: COG0517 362663006329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362663006330 Transporter associated domain; Region: CorC_HlyC; smart01091 362663006331 putative assembly protein; Provisional; Region: PRK10833 362663006332 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 362663006333 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 362663006334 trimer interface [polypeptide binding]; other site 362663006335 active site 362663006336 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 362663006337 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 362663006338 ATP-binding site [chemical binding]; other site 362663006339 Sugar specificity; other site 362663006340 Pyrimidine base specificity; other site 362663006341 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 362663006342 putative diguanylate cyclase; Provisional; Region: PRK09776 362663006343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663006344 putative active site [active] 362663006345 heme pocket [chemical binding]; other site 362663006346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663006347 putative active site [active] 362663006348 heme pocket [chemical binding]; other site 362663006349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663006350 putative active site [active] 362663006351 heme pocket [chemical binding]; other site 362663006352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663006353 metal binding site [ion binding]; metal-binding site 362663006354 active site 362663006355 I-site; other site 362663006356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663006357 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 362663006358 AlkA N-terminal domain; Region: AlkA_N; smart01009 362663006359 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 362663006360 minor groove reading motif; other site 362663006361 helix-hairpin-helix signature motif; other site 362663006362 substrate binding pocket [chemical binding]; other site 362663006363 active site 362663006364 putative chaperone; Provisional; Region: PRK11678 362663006365 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 362663006366 nucleotide binding site [chemical binding]; other site 362663006367 putative NEF/HSP70 interaction site [polypeptide binding]; other site 362663006368 SBD interface [polypeptide binding]; other site 362663006369 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 362663006370 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 362663006371 substrate binding site [chemical binding]; other site 362663006372 activation loop (A-loop); other site 362663006373 Y-family of DNA polymerases; Region: PolY; cl12025 362663006374 Protein phosphatase 2C; Region: PP2C_2; pfam13672 362663006375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 362663006376 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 362663006377 metal ion-dependent adhesion site (MIDAS); other site 362663006378 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 362663006379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663006380 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663006381 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 362663006382 Protein export membrane protein; Region: SecD_SecF; cl14618 362663006383 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 362663006384 putative transporter; Provisional; Region: PRK10504 362663006385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006386 putative substrate translocation pore; other site 362663006387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 362663006388 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 362663006389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663006390 dimerization interface [polypeptide binding]; other site 362663006391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663006392 dimer interface [polypeptide binding]; other site 362663006393 phosphorylation site [posttranslational modification] 362663006394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663006395 ATP binding site [chemical binding]; other site 362663006396 Mg2+ binding site [ion binding]; other site 362663006397 G-X-G motif; other site 362663006398 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 362663006399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006400 active site 362663006401 phosphorylation site [posttranslational modification] 362663006402 intermolecular recognition site; other site 362663006403 dimerization interface [polypeptide binding]; other site 362663006404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663006405 DNA binding site [nucleotide binding] 362663006406 Uncharacterized conserved protein [Function unknown]; Region: COG3422 362663006407 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 362663006408 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 362663006409 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 362663006410 PcfJ-like protein; Region: PcfJ; pfam14284 362663006411 putative protease; Provisional; Region: PRK15452 362663006412 Peptidase family U32; Region: Peptidase_U32; pfam01136 362663006413 lipid kinase; Reviewed; Region: PRK13054 362663006414 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 362663006415 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663006416 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663006417 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663006418 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 362663006419 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 362663006420 putative NAD(P) binding site [chemical binding]; other site 362663006421 catalytic Zn binding site [ion binding]; other site 362663006422 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 362663006423 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 362663006424 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 362663006425 active site 362663006426 P-loop; other site 362663006427 phosphorylation site [posttranslational modification] 362663006428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663006429 active site 362663006430 phosphorylation site [posttranslational modification] 362663006431 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 362663006432 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362663006433 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 362663006434 intersubunit interface [polypeptide binding]; other site 362663006435 active site 362663006436 zinc binding site [ion binding]; other site 362663006437 Na+ binding site [ion binding]; other site 362663006438 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 362663006439 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 362663006440 putative active site; other site 362663006441 catalytic residue [active] 362663006442 nucleoside transporter; Region: 2A0110; TIGR00889 362663006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006444 putative substrate translocation pore; other site 362663006445 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 362663006446 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663006447 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 362663006448 substrate binding site [chemical binding]; other site 362663006449 ATP binding site [chemical binding]; other site 362663006450 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 362663006451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663006452 DNA-binding site [nucleotide binding]; DNA binding site 362663006453 UTRA domain; Region: UTRA; pfam07702 362663006454 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 362663006455 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 362663006456 active site 362663006457 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 362663006458 dimer interface [polypeptide binding]; other site 362663006459 substrate binding site [chemical binding]; other site 362663006460 ATP binding site [chemical binding]; other site 362663006461 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 362663006462 substrate binding site [chemical binding]; other site 362663006463 multimerization interface [polypeptide binding]; other site 362663006464 ATP binding site [chemical binding]; other site 362663006465 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 362663006466 putative metal binding site [ion binding]; other site 362663006467 putative homodimer interface [polypeptide binding]; other site 362663006468 putative homotetramer interface [polypeptide binding]; other site 362663006469 putative homodimer-homodimer interface [polypeptide binding]; other site 362663006470 putative allosteric switch controlling residues; other site 362663006471 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 362663006472 Predicted integral membrane protein [Function unknown]; Region: COG5455 362663006473 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 362663006474 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 362663006475 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 362663006476 PapC N-terminal domain; Region: PapC_N; pfam13954 362663006477 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663006478 PapC C-terminal domain; Region: PapC_C; pfam13953 362663006479 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 362663006480 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663006481 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663006482 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663006483 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 362663006484 antiporter inner membrane protein; Provisional; Region: PRK11670 362663006485 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 362663006486 Walker A motif; other site 362663006487 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 362663006488 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 362663006489 active site 362663006490 HIGH motif; other site 362663006491 KMSKS motif; other site 362663006492 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 362663006493 tRNA binding surface [nucleotide binding]; other site 362663006494 anticodon binding site; other site 362663006495 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 362663006496 dimer interface [polypeptide binding]; other site 362663006497 putative tRNA-binding site [nucleotide binding]; other site 362663006498 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 362663006499 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 362663006500 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 362663006501 MoxR-like ATPases [General function prediction only]; Region: COG0714 362663006502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663006503 Walker A motif; other site 362663006504 ATP binding site [chemical binding]; other site 362663006505 Walker B motif; other site 362663006506 arginine finger; other site 362663006507 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 362663006508 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 362663006509 metal ion-dependent adhesion site (MIDAS); other site 362663006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 362663006511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 362663006512 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 362663006513 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 362663006514 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 362663006515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006516 active site 362663006517 phosphorylation site [posttranslational modification] 362663006518 intermolecular recognition site; other site 362663006519 dimerization interface [polypeptide binding]; other site 362663006520 LytTr DNA-binding domain; Region: LytTR; pfam04397 362663006521 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 362663006522 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 362663006523 GAF domain; Region: GAF; pfam01590 362663006524 Histidine kinase; Region: His_kinase; pfam06580 362663006525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663006526 ATP binding site [chemical binding]; other site 362663006527 Mg2+ binding site [ion binding]; other site 362663006528 G-X-G motif; other site 362663006529 transcriptional regulator MirA; Provisional; Region: PRK15043 362663006530 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 362663006531 DNA binding residues [nucleotide binding] 362663006532 hypothetical protein; Provisional; Region: PRK13681 362663006533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 362663006534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663006535 dimer interface [polypeptide binding]; other site 362663006536 conserved gate region; other site 362663006537 putative PBP binding loops; other site 362663006538 ABC-ATPase subunit interface; other site 362663006539 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362663006540 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 362663006541 Walker A/P-loop; other site 362663006542 ATP binding site [chemical binding]; other site 362663006543 Q-loop/lid; other site 362663006544 ABC transporter signature motif; other site 362663006545 Walker B; other site 362663006546 D-loop; other site 362663006547 H-loop/switch region; other site 362663006548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663006549 dimer interface [polypeptide binding]; other site 362663006550 conserved gate region; other site 362663006551 ABC-ATPase subunit interface; other site 362663006552 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 362663006553 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 362663006554 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 362663006555 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 362663006556 D-lactate dehydrogenase; Provisional; Region: PRK11183 362663006557 FAD binding domain; Region: FAD_binding_4; pfam01565 362663006558 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 362663006559 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 362663006560 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 362663006561 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 362663006562 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362663006563 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 362663006564 oxidoreductase; Provisional; Region: PRK12743 362663006565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362663006566 NAD(P) binding site [chemical binding]; other site 362663006567 active site 362663006568 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 362663006569 Class I aldolases; Region: Aldolase_Class_I; cl17187 362663006570 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 362663006571 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 362663006572 FMN binding site [chemical binding]; other site 362663006573 active site 362663006574 catalytic residues [active] 362663006575 substrate binding site [chemical binding]; other site 362663006576 hypothetical protein; Provisional; Region: PRK01821 362663006577 hypothetical protein; Provisional; Region: PRK10711 362663006578 cytidine deaminase; Provisional; Region: PRK09027 362663006579 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 362663006580 active site 362663006581 catalytic motif [active] 362663006582 Zn binding site [ion binding]; other site 362663006583 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 362663006584 active site 362663006585 catalytic motif [active] 362663006586 Zn binding site [ion binding]; other site 362663006587 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 362663006588 putative active site [active] 362663006589 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 362663006590 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 362663006591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 362663006592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663006593 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 362663006594 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 362663006595 homodimer interface [polypeptide binding]; other site 362663006596 active site 362663006597 FMN binding site [chemical binding]; other site 362663006598 substrate binding site [chemical binding]; other site 362663006599 4Fe-4S binding domain; Region: Fer4; pfam00037 362663006600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663006601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663006602 TM-ABC transporter signature motif; other site 362663006603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663006604 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 362663006605 Walker A/P-loop; other site 362663006606 ATP binding site [chemical binding]; other site 362663006607 Q-loop/lid; other site 362663006608 ABC transporter signature motif; other site 362663006609 Walker B; other site 362663006610 D-loop; other site 362663006611 H-loop/switch region; other site 362663006612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663006613 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 362663006614 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 362663006615 ligand binding site [chemical binding]; other site 362663006616 calcium binding site [ion binding]; other site 362663006617 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 362663006618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663006619 DNA binding site [nucleotide binding] 362663006620 domain linker motif; other site 362663006621 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 362663006622 dimerization interface (closed form) [polypeptide binding]; other site 362663006623 ligand binding site [chemical binding]; other site 362663006624 Predicted membrane protein [Function unknown]; Region: COG2311 362663006625 hypothetical protein; Provisional; Region: PRK10835 362663006626 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 362663006627 homodecamer interface [polypeptide binding]; other site 362663006628 GTP cyclohydrolase I; Provisional; Region: PLN03044 362663006629 active site 362663006630 putative catalytic site residues [active] 362663006631 zinc binding site [ion binding]; other site 362663006632 GTP-CH-I/GFRP interaction surface; other site 362663006633 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 362663006634 S-formylglutathione hydrolase; Region: PLN02442 362663006635 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 362663006636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663006637 N-terminal plug; other site 362663006638 ligand-binding site [chemical binding]; other site 362663006639 lysine transporter; Provisional; Region: PRK10836 362663006640 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 362663006641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663006642 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 362663006643 putative dimerization interface [polypeptide binding]; other site 362663006644 conserved hypothetical integral membrane protein; Region: TIGR00698 362663006645 endonuclease IV; Provisional; Region: PRK01060 362663006646 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 362663006647 AP (apurinic/apyrimidinic) site pocket; other site 362663006648 DNA interaction; other site 362663006649 Metal-binding active site; metal-binding site 362663006650 putative kinase; Provisional; Region: PRK09954 362663006651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663006652 putative DNA binding site [nucleotide binding]; other site 362663006653 putative Zn2+ binding site [ion binding]; other site 362663006654 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 362663006655 substrate binding site [chemical binding]; other site 362663006656 ATP binding site [chemical binding]; other site 362663006657 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 362663006658 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 362663006659 Nucleoside recognition; Region: Gate; pfam07670 362663006660 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 362663006661 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 362663006662 active site 362663006663 tetramer interface [polypeptide binding]; other site 362663006664 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 362663006665 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 362663006666 ligand binding site [chemical binding]; other site 362663006667 flexible hinge region; other site 362663006668 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 362663006669 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 362663006670 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 362663006671 Nucleoside recognition; Region: Gate; pfam07670 362663006672 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 362663006673 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 362663006674 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 362663006675 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663006676 substrate binding site [chemical binding]; other site 362663006677 ATP binding site [chemical binding]; other site 362663006678 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 362663006679 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 362663006680 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362663006681 active site 362663006682 P-loop; other site 362663006683 phosphorylation site [posttranslational modification] 362663006684 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 362663006685 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 362663006686 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 362663006687 putative substrate binding site [chemical binding]; other site 362663006688 putative ATP binding site [chemical binding]; other site 362663006689 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 362663006690 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663006691 active site 362663006692 phosphorylation site [posttranslational modification] 362663006693 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663006694 dimerization domain swap beta strand [polypeptide binding]; other site 362663006695 regulatory protein interface [polypeptide binding]; other site 362663006696 active site 362663006697 regulatory phosphorylation site [posttranslational modification]; other site 362663006698 sugar efflux transporter B; Provisional; Region: PRK15011 362663006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006700 putative substrate translocation pore; other site 362663006701 Flagellin N-methylase; Region: FliB; pfam03692 362663006702 elongation factor P; Provisional; Region: PRK04542 362663006703 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 362663006704 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 362663006705 RNA binding site [nucleotide binding]; other site 362663006706 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 362663006707 RNA binding site [nucleotide binding]; other site 362663006708 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 362663006709 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663006710 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663006711 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 362663006712 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 362663006713 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 362663006714 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 362663006715 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 362663006716 active site 362663006717 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 362663006718 NlpC/P60 family; Region: NLPC_P60; pfam00877 362663006719 phage resistance protein; Provisional; Region: PRK10551 362663006720 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 362663006721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663006722 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 362663006723 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 362663006724 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 362663006725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663006726 dimer interface [polypeptide binding]; other site 362663006727 conserved gate region; other site 362663006728 putative PBP binding loops; other site 362663006729 ABC-ATPase subunit interface; other site 362663006730 microcin C ABC transporter permease; Provisional; Region: PRK15021 362663006731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663006732 dimer interface [polypeptide binding]; other site 362663006733 conserved gate region; other site 362663006734 ABC-ATPase subunit interface; other site 362663006735 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 362663006736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663006737 Walker A/P-loop; other site 362663006738 ATP binding site [chemical binding]; other site 362663006739 Q-loop/lid; other site 362663006740 ABC transporter signature motif; other site 362663006741 Walker B; other site 362663006742 D-loop; other site 362663006743 H-loop/switch region; other site 362663006744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362663006745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663006746 Walker A/P-loop; other site 362663006747 ATP binding site [chemical binding]; other site 362663006748 Q-loop/lid; other site 362663006749 ABC transporter signature motif; other site 362663006750 Walker B; other site 362663006751 D-loop; other site 362663006752 H-loop/switch region; other site 362663006753 hypothetical protein; Provisional; Region: PRK11835 362663006754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006755 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 362663006756 putative substrate translocation pore; other site 362663006757 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 362663006758 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663006759 RNA binding surface [nucleotide binding]; other site 362663006760 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 362663006761 active site 362663006762 uracil binding [chemical binding]; other site 362663006763 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 362663006764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663006765 ATP binding site [chemical binding]; other site 362663006766 putative Mg++ binding site [ion binding]; other site 362663006767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663006768 nucleotide binding region [chemical binding]; other site 362663006769 ATP-binding site [chemical binding]; other site 362663006770 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 362663006771 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 362663006772 5S rRNA interface [nucleotide binding]; other site 362663006773 CTC domain interface [polypeptide binding]; other site 362663006774 L16 interface [polypeptide binding]; other site 362663006775 Nucleoid-associated protein [General function prediction only]; Region: COG3081 362663006776 nucleoid-associated protein NdpA; Validated; Region: PRK00378 362663006777 hypothetical protein; Provisional; Region: PRK13689 362663006778 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 362663006779 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 362663006780 Sulfatase; Region: Sulfatase; pfam00884 362663006781 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663006782 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 362663006783 transcriptional regulator NarP; Provisional; Region: PRK10403 362663006784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006785 active site 362663006786 phosphorylation site [posttranslational modification] 362663006787 intermolecular recognition site; other site 362663006788 dimerization interface [polypeptide binding]; other site 362663006789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663006790 DNA binding residues [nucleotide binding] 362663006791 dimerization interface [polypeptide binding]; other site 362663006792 Cytochrome C biogenesis protein; Region: CcmH; cl01179 362663006793 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 362663006794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663006795 binding surface 362663006796 TPR motif; other site 362663006797 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 362663006798 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 362663006799 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 362663006800 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 362663006801 cytochrome c-type biogenesis protein CcmC nonfunction due to the frame shift 362663006802 cytochrome c-type biogenesis protein CcmC nonfunction due to the frame shift 362663006803 heme exporter protein CcmB; Region: ccmB; TIGR01190 362663006804 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 362663006805 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 362663006806 Walker A/P-loop; other site 362663006807 ATP binding site [chemical binding]; other site 362663006808 Q-loop/lid; other site 362663006809 ABC transporter signature motif; other site 362663006810 Walker B; other site 362663006811 D-loop; other site 362663006812 H-loop/switch region; other site 362663006813 cytochrome c-type protein NapC; Provisional; Region: PRK10617 362663006814 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 362663006815 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 362663006816 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 362663006817 4Fe-4S binding domain; Region: Fer4_5; pfam12801 362663006818 4Fe-4S binding domain; Region: Fer4_6; pfam12837 362663006819 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 362663006820 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 362663006821 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 362663006822 [4Fe-4S] binding site [ion binding]; other site 362663006823 molybdopterin cofactor binding site; other site 362663006824 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 362663006825 molybdopterin cofactor binding site; other site 362663006826 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 362663006827 ferredoxin-type protein; Provisional; Region: PRK10194 362663006828 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 362663006829 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 362663006830 secondary substrate binding site; other site 362663006831 primary substrate binding site; other site 362663006832 inhibition loop; other site 362663006833 dimerization interface [polypeptide binding]; other site 362663006834 malate:quinone oxidoreductase; Validated; Region: PRK05257 362663006835 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 362663006836 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 362663006837 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 362663006838 Walker A/P-loop; other site 362663006839 ATP binding site [chemical binding]; other site 362663006840 Q-loop/lid; other site 362663006841 ABC transporter signature motif; other site 362663006842 Walker B; other site 362663006843 D-loop; other site 362663006844 H-loop/switch region; other site 362663006845 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 362663006846 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 362663006847 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 362663006848 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 362663006849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663006850 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 362663006851 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 362663006852 DNA binding site [nucleotide binding] 362663006853 active site 362663006854 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 362663006855 ApbE family; Region: ApbE; pfam02424 362663006856 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 362663006857 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 362663006858 trimer interface [polypeptide binding]; other site 362663006859 eyelet of channel; other site 362663006860 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 362663006861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663006862 ATP binding site [chemical binding]; other site 362663006863 G-X-G motif; other site 362663006864 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663006865 putative binding surface; other site 362663006866 active site 362663006867 transcriptional regulator RcsB; Provisional; Region: PRK10840 362663006868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006869 active site 362663006870 phosphorylation site [posttranslational modification] 362663006871 intermolecular recognition site; other site 362663006872 dimerization interface [polypeptide binding]; other site 362663006873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663006874 DNA binding residues [nucleotide binding] 362663006875 dimerization interface [polypeptide binding]; other site 362663006876 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 362663006877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663006878 dimer interface [polypeptide binding]; other site 362663006879 phosphorylation site [posttranslational modification] 362663006880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663006881 ATP binding site [chemical binding]; other site 362663006882 Mg2+ binding site [ion binding]; other site 362663006883 G-X-G motif; other site 362663006884 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 362663006885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006886 active site 362663006887 phosphorylation site [posttranslational modification] 362663006888 intermolecular recognition site; other site 362663006889 dimerization interface [polypeptide binding]; other site 362663006890 sensory histidine kinase AtoS; Provisional; Region: PRK11360 362663006891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663006892 putative active site [active] 362663006893 heme pocket [chemical binding]; other site 362663006894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663006895 dimer interface [polypeptide binding]; other site 362663006896 phosphorylation site [posttranslational modification] 362663006897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663006898 ATP binding site [chemical binding]; other site 362663006899 Mg2+ binding site [ion binding]; other site 362663006900 G-X-G motif; other site 362663006901 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 362663006902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663006903 active site 362663006904 phosphorylation site [posttranslational modification] 362663006905 intermolecular recognition site; other site 362663006906 dimerization interface [polypeptide binding]; other site 362663006907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663006908 Walker A motif; other site 362663006909 ATP binding site [chemical binding]; other site 362663006910 Walker B motif; other site 362663006911 arginine finger; other site 362663006912 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663006913 acetate CoA-transferase alpha subunit nonfunction due to the frame shift 362663006914 acetate CoA-transferase alpha subunit nonfunction due to the frame shift 362663006915 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 362663006916 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 362663006917 putative acyltransferase; Provisional; Region: PRK05790 362663006918 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 362663006919 dimer interface [polypeptide binding]; other site 362663006920 active site 362663006921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 362663006922 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 362663006923 Predicted secreted protein [Function unknown]; Region: COG5445 362663006924 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 362663006925 Predicted secreted protein [Function unknown]; Region: COG5445 362663006926 Stage II sporulation protein; Region: SpoIID; pfam08486 362663006927 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 362663006928 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 362663006929 MG2 domain; Region: A2M_N; pfam01835 362663006930 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 362663006931 Alpha-2-macroglobulin family; Region: A2M; pfam00207 362663006932 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 362663006933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 362663006934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 362663006935 DNA gyrase subunit A; Validated; Region: PRK05560 362663006936 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 362663006937 CAP-like domain; other site 362663006938 active site 362663006939 primary dimer interface [polypeptide binding]; other site 362663006940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006941 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006942 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006944 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006945 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663006946 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 362663006947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663006948 S-adenosylmethionine binding site [chemical binding]; other site 362663006949 adhesin; Provisional; Region: PRK09752 362663006950 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 362663006951 Autotransporter beta-domain; Region: Autotransporter; pfam03797 362663006952 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 362663006953 ATP cone domain; Region: ATP-cone; pfam03477 362663006954 Class I ribonucleotide reductase; Region: RNR_I; cd01679 362663006955 active site 362663006956 dimer interface [polypeptide binding]; other site 362663006957 catalytic residues [active] 362663006958 effector binding site; other site 362663006959 R2 peptide binding site; other site 362663006960 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 362663006961 dimer interface [polypeptide binding]; other site 362663006962 putative radical transfer pathway; other site 362663006963 diiron center [ion binding]; other site 362663006964 tyrosyl radical; other site 362663006965 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 362663006966 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663006967 catalytic loop [active] 362663006968 iron binding site [ion binding]; other site 362663006969 hypothetical protein; Provisional; Region: PRK09902 362663006970 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 362663006971 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 362663006972 active site 362663006973 catalytic site [active] 362663006974 metal binding site [ion binding]; metal-binding site 362663006975 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 362663006976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006977 putative substrate translocation pore; other site 362663006978 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 362663006979 hydroxyglutarate oxidase; Provisional; Region: PRK11728 362663006980 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 362663006981 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 362663006982 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 362663006983 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 362663006984 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663006985 Cysteine-rich domain; Region: CCG; pfam02754 362663006986 Cysteine-rich domain; Region: CCG; pfam02754 362663006987 hypothetical protein; Provisional; Region: PRK09956 362663006988 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 362663006989 hypothetical protein; Provisional; Region: PRK09956 362663006990 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 362663006991 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 362663006992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663006993 putative substrate translocation pore; other site 362663006994 L-rhamnonate dehydratase; Provisional; Region: PRK15440 362663006995 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 362663006996 putative active site pocket [active] 362663006997 putative metal binding site [ion binding]; other site 362663006998 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 362663006999 Transcriptional regulator [Transcription]; Region: IclR; COG1414 362663007000 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663007001 hypothetical protein; Provisional; Region: PRK03673 362663007002 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 362663007003 putative MPT binding site; other site 362663007004 Competence-damaged protein; Region: CinA; cl00666 362663007005 YfaZ precursor; Region: YfaZ; pfam07437 362663007006 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 362663007007 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 362663007008 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 362663007009 catalytic core [active] 362663007010 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 362663007011 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 362663007012 inhibitor-cofactor binding pocket; inhibition site 362663007013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663007014 catalytic residue [active] 362663007015 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 362663007016 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 362663007017 Ligand binding site; other site 362663007018 Putative Catalytic site; other site 362663007019 DXD motif; other site 362663007020 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 362663007021 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 362663007022 substrate binding site [chemical binding]; other site 362663007023 cosubstrate binding site; other site 362663007024 catalytic site [active] 362663007025 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 362663007026 active site 362663007027 hexamer interface [polypeptide binding]; other site 362663007028 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 362663007029 NAD binding site [chemical binding]; other site 362663007030 substrate binding site [chemical binding]; other site 362663007031 active site 362663007032 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 362663007033 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 362663007034 putative active site [active] 362663007035 putative catalytic site [active] 362663007036 putative Zn binding site [ion binding]; other site 362663007037 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 362663007038 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 362663007039 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 362663007040 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 362663007041 signal transduction protein PmrD; Provisional; Region: PRK15450 362663007042 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 362663007043 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 362663007044 acyl-activating enzyme (AAE) consensus motif; other site 362663007045 putative AMP binding site [chemical binding]; other site 362663007046 putative active site [active] 362663007047 putative CoA binding site [chemical binding]; other site 362663007048 O-succinylbenzoate synthase; Provisional; Region: PRK05105 362663007049 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 362663007050 active site 362663007051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362663007052 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 362663007053 substrate binding site [chemical binding]; other site 362663007054 oxyanion hole (OAH) forming residues; other site 362663007055 trimer interface [polypeptide binding]; other site 362663007056 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 362663007057 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 362663007058 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 362663007059 dimer interface [polypeptide binding]; other site 362663007060 tetramer interface [polypeptide binding]; other site 362663007061 PYR/PP interface [polypeptide binding]; other site 362663007062 TPP binding site [chemical binding]; other site 362663007063 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 362663007064 TPP-binding site; other site 362663007065 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 362663007066 chorismate binding enzyme; Region: Chorismate_bind; cl10555 362663007067 hypothetical protein; Provisional; Region: PRK10404 362663007068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663007069 Coenzyme A binding pocket [chemical binding]; other site 362663007070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 362663007071 M28 Zn-Peptidases; Region: M28_like_1; cd05640 362663007072 Peptidase family M28; Region: Peptidase_M28; pfam04389 362663007073 metal binding site [ion binding]; metal-binding site 362663007074 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 362663007075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 362663007076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 362663007077 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 362663007078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 362663007079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 362663007080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 362663007081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 362663007082 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 362663007083 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 362663007084 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 362663007085 4Fe-4S binding domain; Region: Fer4; pfam00037 362663007086 4Fe-4S binding domain; Region: Fer4; pfam00037 362663007087 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 362663007088 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 362663007089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663007090 catalytic loop [active] 362663007091 iron binding site [ion binding]; other site 362663007092 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 362663007093 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 362663007094 [4Fe-4S] binding site [ion binding]; other site 362663007095 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 362663007096 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 362663007097 SLBB domain; Region: SLBB; pfam10531 362663007098 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 362663007099 NADH dehydrogenase subunit E; Validated; Region: PRK07539 362663007100 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 362663007101 putative dimer interface [polypeptide binding]; other site 362663007102 [2Fe-2S] cluster binding site [ion binding]; other site 362663007103 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 362663007104 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 362663007105 NADH dehydrogenase subunit D; Validated; Region: PRK06075 362663007106 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 362663007107 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 362663007108 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 362663007109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663007110 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 362663007111 putative dimerization interface [polypeptide binding]; other site 362663007112 aminotransferase AlaT; Validated; Region: PRK09265 362663007113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663007114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663007115 homodimer interface [polypeptide binding]; other site 362663007116 catalytic residue [active] 362663007117 5'-nucleotidase; Provisional; Region: PRK03826 362663007118 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 362663007119 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663007120 TrkA-C domain; Region: TrkA_C; pfam02080 362663007121 TrkA-C domain; Region: TrkA_C; pfam02080 362663007122 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 362663007123 putative phosphatase; Provisional; Region: PRK11587 362663007124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663007125 motif II; other site 362663007126 hypothetical protein; Validated; Region: PRK05445 362663007127 hypothetical protein; Provisional; Region: PRK01816 362663007128 propionate/acetate kinase; Provisional; Region: PRK12379 362663007129 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 362663007130 phosphate acetyltransferase; Reviewed; Region: PRK05632 362663007131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 362663007132 DRTGG domain; Region: DRTGG; pfam07085 362663007133 phosphate acetyltransferase; Region: pta; TIGR00651 362663007134 hypothetical protein; Provisional; Region: PRK11588 362663007135 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 362663007136 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 362663007137 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 362663007138 nudix motif; other site 362663007139 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 362663007140 active site 362663007141 metal binding site [ion binding]; metal-binding site 362663007142 homotetramer interface [polypeptide binding]; other site 362663007143 glutathione S-transferase; Provisional; Region: PRK15113 362663007144 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 362663007145 C-terminal domain interface [polypeptide binding]; other site 362663007146 GSH binding site (G-site) [chemical binding]; other site 362663007147 dimer interface [polypeptide binding]; other site 362663007148 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 362663007149 N-terminal domain interface [polypeptide binding]; other site 362663007150 putative dimer interface [polypeptide binding]; other site 362663007151 putative substrate binding pocket (H-site) [chemical binding]; other site 362663007152 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 362663007153 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 362663007154 C-terminal domain interface [polypeptide binding]; other site 362663007155 GSH binding site (G-site) [chemical binding]; other site 362663007156 dimer interface [polypeptide binding]; other site 362663007157 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 362663007158 N-terminal domain interface [polypeptide binding]; other site 362663007159 putative dimer interface [polypeptide binding]; other site 362663007160 active site 362663007161 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 362663007162 homooctamer interface [polypeptide binding]; other site 362663007163 active site 362663007164 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 362663007165 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 362663007166 putative NAD(P) binding site [chemical binding]; other site 362663007167 putative active site [active] 362663007168 putative transposase; Provisional; Region: PRK09857 362663007169 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 362663007170 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 362663007171 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362663007172 Walker A/P-loop; other site 362663007173 ATP binding site [chemical binding]; other site 362663007174 Q-loop/lid; other site 362663007175 ABC transporter signature motif; other site 362663007176 Walker B; other site 362663007177 D-loop; other site 362663007178 H-loop/switch region; other site 362663007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663007180 dimer interface [polypeptide binding]; other site 362663007181 conserved gate region; other site 362663007182 putative PBP binding loops; other site 362663007183 ABC-ATPase subunit interface; other site 362663007184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663007185 dimer interface [polypeptide binding]; other site 362663007186 conserved gate region; other site 362663007187 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 362663007188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663007189 substrate binding pocket [chemical binding]; other site 362663007190 membrane-bound complex binding site; other site 362663007191 hinge residues; other site 362663007192 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 362663007193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663007194 substrate binding pocket [chemical binding]; other site 362663007195 membrane-bound complex binding site; other site 362663007196 hinge residues; other site 362663007197 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 362663007198 Flavoprotein; Region: Flavoprotein; pfam02441 362663007199 amidophosphoribosyltransferase; Provisional; Region: PRK09246 362663007200 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 362663007201 active site 362663007202 tetramer interface [polypeptide binding]; other site 362663007203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663007204 active site 362663007205 colicin V production protein; Provisional; Region: PRK10845 362663007206 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 362663007207 cell division protein DedD; Provisional; Region: PRK11633 362663007208 Sporulation related domain; Region: SPOR; pfam05036 362663007209 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 362663007210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663007211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663007212 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 362663007213 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 362663007214 hypothetical protein; Provisional; Region: PRK10847 362663007215 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362663007216 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 362663007217 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 362663007218 dimerization interface 3.5A [polypeptide binding]; other site 362663007219 active site 362663007220 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 362663007221 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 362663007222 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 362663007223 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 362663007224 ligand binding site [chemical binding]; other site 362663007225 NAD binding site [chemical binding]; other site 362663007226 catalytic site [active] 362663007227 homodimer interface [polypeptide binding]; other site 362663007228 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 362663007229 putative transporter; Provisional; Region: PRK12382 362663007230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007231 putative substrate translocation pore; other site 362663007232 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 362663007233 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 362663007234 dimer interface [polypeptide binding]; other site 362663007235 active site 362663007236 Uncharacterized conserved protein [Function unknown]; Region: COG4121 362663007237 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 362663007238 YfcL protein; Region: YfcL; pfam08891 362663007239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 362663007240 hypothetical protein; Provisional; Region: PRK10621 362663007241 Predicted permeases [General function prediction only]; Region: COG0730 362663007242 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 362663007243 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 362663007244 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 362663007245 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 362663007246 Tetramer interface [polypeptide binding]; other site 362663007247 active site 362663007248 FMN-binding site [chemical binding]; other site 362663007249 HemK family putative methylases; Region: hemK_fam; TIGR00536 362663007250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663007251 S-adenosylmethionine binding site [chemical binding]; other site 362663007252 hypothetical protein; Provisional; Region: PRK04946 362663007253 Smr domain; Region: Smr; pfam01713 362663007254 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 362663007255 Fimbrial protein; Region: Fimbrial; cl01416 362663007256 Fimbrial protein; Region: Fimbrial; cl01416 362663007257 Fimbrial protein; Region: Fimbrial; cl01416 362663007258 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663007259 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663007260 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 362663007261 PapC N-terminal domain; Region: PapC_N; pfam13954 362663007262 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663007263 PapC C-terminal domain; Region: PapC_C; pfam13953 362663007264 Fimbrial protein; Region: Fimbrial; cl01416 362663007265 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362663007266 catalytic core [active] 362663007267 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 362663007268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362663007269 substrate binding site [chemical binding]; other site 362663007270 oxyanion hole (OAH) forming residues; other site 362663007271 trimer interface [polypeptide binding]; other site 362663007272 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 362663007273 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 362663007274 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 362663007275 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 362663007276 dimer interface [polypeptide binding]; other site 362663007277 active site 362663007278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 362663007279 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 362663007280 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 362663007281 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 362663007282 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 362663007283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007284 putative substrate translocation pore; other site 362663007285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663007286 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 362663007287 putative substrate binding site [chemical binding]; other site 362663007288 putative ATP binding site [chemical binding]; other site 362663007289 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 362663007290 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 362663007291 substrate binding [chemical binding]; other site 362663007292 active site 362663007293 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 362663007294 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663007295 DNA binding site [nucleotide binding] 362663007296 domain linker motif; other site 362663007297 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 362663007298 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 362663007299 putative dimerization interface [polypeptide binding]; other site 362663007300 putative ligand binding site [chemical binding]; other site 362663007301 fructuronate transporter; Provisional; Region: PRK10034; cl15264 362663007302 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 362663007303 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 362663007304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663007305 catalytic residue [active] 362663007306 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 362663007307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007308 putative substrate translocation pore; other site 362663007309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007310 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 362663007311 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663007312 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 362663007313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663007314 active site 362663007315 phosphorylation site [posttranslational modification] 362663007316 intermolecular recognition site; other site 362663007317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663007318 DNA binding residues [nucleotide binding] 362663007319 dimerization interface [polypeptide binding]; other site 362663007320 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 362663007321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663007322 substrate binding pocket [chemical binding]; other site 362663007323 membrane-bound complex binding site; other site 362663007324 hinge residues; other site 362663007325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663007326 substrate binding pocket [chemical binding]; other site 362663007327 membrane-bound complex binding site; other site 362663007328 hinge residues; other site 362663007329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663007330 dimer interface [polypeptide binding]; other site 362663007331 phosphorylation site [posttranslational modification] 362663007332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663007333 ATP binding site [chemical binding]; other site 362663007334 Mg2+ binding site [ion binding]; other site 362663007335 G-X-G motif; other site 362663007336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663007337 active site 362663007338 phosphorylation site [posttranslational modification] 362663007339 intermolecular recognition site; other site 362663007340 dimerization interface [polypeptide binding]; other site 362663007341 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663007342 putative binding surface; other site 362663007343 active site 362663007344 putative CoA-transferase; Provisional; Region: PRK11430 362663007345 CoA-transferase family III; Region: CoA_transf_3; pfam02515 362663007346 putative transporter YfdV; Provisional; Region: PRK09903 362663007347 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 362663007348 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362663007349 PYR/PP interface [polypeptide binding]; other site 362663007350 dimer interface [polypeptide binding]; other site 362663007351 TPP binding site [chemical binding]; other site 362663007352 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663007353 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 362663007354 TPP-binding site; other site 362663007355 dimer interface [polypeptide binding]; other site 362663007356 formyl-coenzyme A transferase; Provisional; Region: PRK05398 362663007357 CoA-transferase family III; Region: CoA_transf_3; pfam02515 362663007358 hypothetical protein; Provisional; Region: PRK10316 362663007359 YfdX protein; Region: YfdX; pfam10938 362663007360 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 362663007361 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 362663007362 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 362663007363 putative acyl-acceptor binding pocket; other site 362663007364 aminotransferase; Validated; Region: PRK08175 362663007365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663007366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663007367 homodimer interface [polypeptide binding]; other site 362663007368 catalytic residue [active] 362663007369 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 362663007370 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 362663007371 GAF domain; Region: GAF; cl17456 362663007372 Histidine kinase; Region: His_kinase; pfam06580 362663007373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663007374 ATP binding site [chemical binding]; other site 362663007375 Mg2+ binding site [ion binding]; other site 362663007376 G-X-G motif; other site 362663007377 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 362663007378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663007379 active site 362663007380 phosphorylation site [posttranslational modification] 362663007381 intermolecular recognition site; other site 362663007382 dimerization interface [polypeptide binding]; other site 362663007383 LytTr DNA-binding domain; Region: LytTR; pfam04397 362663007384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663007385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663007386 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663007387 dimerization domain swap beta strand [polypeptide binding]; other site 362663007388 regulatory protein interface [polypeptide binding]; other site 362663007389 active site 362663007390 regulatory phosphorylation site [posttranslational modification]; other site 362663007391 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 362663007392 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 362663007393 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663007394 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663007395 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663007396 active site 362663007397 phosphorylation site [posttranslational modification] 362663007398 exoaminopeptidase; Provisional; Region: PRK09961 362663007399 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 362663007400 oligomer interface [polypeptide binding]; other site 362663007401 active site 362663007402 metal binding site [ion binding]; metal-binding site 362663007403 aminopeptidase; Provisional; Region: PRK09795 362663007404 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 362663007405 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 362663007406 active site 362663007407 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 362663007408 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362663007409 active site 362663007410 P-loop; other site 362663007411 phosphorylation site [posttranslational modification] 362663007412 glucokinase, proteobacterial type; Region: glk; TIGR00749 362663007413 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663007414 nucleotide binding site [chemical binding]; other site 362663007415 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 362663007416 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 362663007417 Cl- selectivity filter; other site 362663007418 Cl- binding residues [ion binding]; other site 362663007419 pore gating glutamate residue; other site 362663007420 dimer interface [polypeptide binding]; other site 362663007421 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 362663007422 manganese transport protein MntH; Reviewed; Region: PRK00701 362663007423 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 362663007424 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 362663007425 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 362663007426 Nucleoside recognition; Region: Gate; pfam07670 362663007427 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 362663007428 MASE1; Region: MASE1; pfam05231 362663007429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663007430 diguanylate cyclase; Region: GGDEF; smart00267 362663007431 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663007432 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 362663007433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663007434 salt bridge; other site 362663007435 non-specific DNA binding site [nucleotide binding]; other site 362663007436 sequence-specific DNA binding site [nucleotide binding]; other site 362663007437 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 362663007438 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 362663007439 active site 362663007440 HIGH motif; other site 362663007441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 362663007442 active site 362663007443 KMSKS motif; other site 362663007444 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 362663007445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663007446 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 362663007447 putative dimerization interface [polypeptide binding]; other site 362663007448 putative substrate binding pocket [chemical binding]; other site 362663007449 XapX domain; Region: XapX; TIGR03510 362663007450 nucleoside transporter; Region: 2A0110; TIGR00889 362663007451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007452 putative substrate translocation pore; other site 362663007453 purine nucleoside phosphorylase; Provisional; Region: PRK08202 362663007454 hypothetical protein; Provisional; Region: PRK11528 362663007455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663007456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663007457 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 362663007458 putative dimerization interface [polypeptide binding]; other site 362663007459 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 362663007460 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 362663007461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 362663007462 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 362663007463 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 362663007464 nucleotide binding pocket [chemical binding]; other site 362663007465 K-X-D-G motif; other site 362663007466 catalytic site [active] 362663007467 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 362663007468 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 362663007469 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 362663007470 Dimer interface [polypeptide binding]; other site 362663007471 BRCT sequence motif; other site 362663007472 cell division protein ZipA; Provisional; Region: PRK03427 362663007473 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 362663007474 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 362663007475 FtsZ protein binding site [polypeptide binding]; other site 362663007476 putative sulfate transport protein CysZ; Validated; Region: PRK04949 362663007477 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 362663007478 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 362663007479 dimer interface [polypeptide binding]; other site 362663007480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663007481 catalytic residue [active] 362663007482 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663007483 dimerization domain swap beta strand [polypeptide binding]; other site 362663007484 regulatory protein interface [polypeptide binding]; other site 362663007485 active site 362663007486 regulatory phosphorylation site [posttranslational modification]; other site 362663007487 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 362663007488 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 362663007489 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663007490 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663007491 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 362663007492 HPr interaction site; other site 362663007493 glycerol kinase (GK) interaction site [polypeptide binding]; other site 362663007494 active site 362663007495 phosphorylation site [posttranslational modification] 362663007496 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 362663007497 dimer interface [polypeptide binding]; other site 362663007498 pyridoxamine kinase; Validated; Region: PRK05756 362663007499 pyridoxal binding site [chemical binding]; other site 362663007500 ATP binding site [chemical binding]; other site 362663007501 hypothetical protein; Provisional; Region: PRK10318 362663007502 cysteine synthase B; Region: cysM; TIGR01138 362663007503 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 362663007504 dimer interface [polypeptide binding]; other site 362663007505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663007506 catalytic residue [active] 362663007507 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 362663007508 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 362663007509 Walker A/P-loop; other site 362663007510 ATP binding site [chemical binding]; other site 362663007511 Q-loop/lid; other site 362663007512 ABC transporter signature motif; other site 362663007513 Walker B; other site 362663007514 D-loop; other site 362663007515 H-loop/switch region; other site 362663007516 TOBE-like domain; Region: TOBE_3; pfam12857 362663007517 sulfate transport protein; Provisional; Region: cysT; CHL00187 362663007518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663007519 dimer interface [polypeptide binding]; other site 362663007520 conserved gate region; other site 362663007521 putative PBP binding loops; other site 362663007522 ABC-ATPase subunit interface; other site 362663007523 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 362663007524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663007525 dimer interface [polypeptide binding]; other site 362663007526 conserved gate region; other site 362663007527 putative PBP binding loops; other site 362663007528 ABC-ATPase subunit interface; other site 362663007529 thiosulfate transporter subunit; Provisional; Region: PRK10852 362663007530 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 362663007531 short chain dehydrogenase; Provisional; Region: PRK08226 362663007532 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 362663007533 NAD binding site [chemical binding]; other site 362663007534 homotetramer interface [polypeptide binding]; other site 362663007535 homodimer interface [polypeptide binding]; other site 362663007536 active site 362663007537 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 362663007538 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 362663007539 putative active site [active] 362663007540 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 362663007541 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663007542 active site turn [active] 362663007543 phosphorylation site [posttranslational modification] 362663007544 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663007545 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 362663007546 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 362663007547 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 362663007548 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 362663007549 putative acetyltransferase; Provisional; Region: PRK03624 362663007550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663007551 Coenzyme A binding pocket [chemical binding]; other site 362663007552 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 362663007553 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 362663007554 active site 362663007555 metal binding site [ion binding]; metal-binding site 362663007556 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 362663007557 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 362663007558 transcriptional regulator EutR; Provisional; Region: PRK10130 362663007559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663007560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663007561 carboxysome structural protein EutK; Provisional; Region: PRK15466 362663007562 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 362663007563 Hexamer interface [polypeptide binding]; other site 362663007564 Hexagonal pore residue; other site 362663007565 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 362663007566 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 362663007567 putative hexamer interface [polypeptide binding]; other site 362663007568 putative hexagonal pore; other site 362663007569 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 362663007570 putative hexamer interface [polypeptide binding]; other site 362663007571 putative hexagonal pore; other site 362663007572 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 362663007573 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 362663007574 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 362663007575 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 362663007576 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 362663007577 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 362663007578 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 362663007579 active site 362663007580 metal binding site [ion binding]; metal-binding site 362663007581 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 362663007582 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663007583 nucleotide binding site [chemical binding]; other site 362663007584 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 362663007585 putative catalytic cysteine [active] 362663007586 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 362663007587 Hexamer/Pentamer interface [polypeptide binding]; other site 362663007588 central pore; other site 362663007589 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 362663007590 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 362663007591 Hexamer interface [polypeptide binding]; other site 362663007592 Putative hexagonal pore residue; other site 362663007593 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 362663007594 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 362663007595 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 362663007596 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 362663007597 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 362663007598 G1 box; other site 362663007599 GTP/Mg2+ binding site [chemical binding]; other site 362663007600 G2 box; other site 362663007601 Switch I region; other site 362663007602 G3 box; other site 362663007603 Switch II region; other site 362663007604 G4 box; other site 362663007605 G5 box; other site 362663007606 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 362663007607 putative hexamer interface [polypeptide binding]; other site 362663007608 putative hexagonal pore; other site 362663007609 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 362663007610 Malic enzyme, N-terminal domain; Region: malic; pfam00390 362663007611 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 362663007612 putative NAD(P) binding site [chemical binding]; other site 362663007613 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 362663007614 transaldolase-like protein; Provisional; Region: PTZ00411 362663007615 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 362663007616 active site 362663007617 dimer interface [polypeptide binding]; other site 362663007618 catalytic residue [active] 362663007619 transketolase; Reviewed; Region: PRK12753 362663007620 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 362663007621 TPP-binding site [chemical binding]; other site 362663007622 dimer interface [polypeptide binding]; other site 362663007623 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362663007624 PYR/PP interface [polypeptide binding]; other site 362663007625 dimer interface [polypeptide binding]; other site 362663007626 TPP binding site [chemical binding]; other site 362663007627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362663007628 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 362663007629 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 362663007630 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 362663007631 dimer interface [polypeptide binding]; other site 362663007632 ADP-ribose binding site [chemical binding]; other site 362663007633 active site 362663007634 nudix motif; other site 362663007635 metal binding site [ion binding]; metal-binding site 362663007636 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 362663007637 4Fe-4S binding domain; Region: Fer4; pfam00037 362663007638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 362663007639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663007640 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 362663007641 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 362663007642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663007643 dimerization interface [polypeptide binding]; other site 362663007644 Histidine kinase; Region: HisKA_3; pfam07730 362663007645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663007646 ATP binding site [chemical binding]; other site 362663007647 Mg2+ binding site [ion binding]; other site 362663007648 G-X-G motif; other site 362663007649 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 362663007650 Protein export membrane protein; Region: SecD_SecF; cl14618 362663007651 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 362663007652 ArsC family; Region: ArsC; pfam03960 362663007653 putative catalytic residues [active] 362663007654 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 362663007655 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 362663007656 metal binding site [ion binding]; metal-binding site 362663007657 dimer interface [polypeptide binding]; other site 362663007658 hypothetical protein; Provisional; Region: PRK13664 362663007659 putative hydrolase; Provisional; Region: PRK11460 362663007660 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 362663007661 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 362663007662 Helicase; Region: Helicase_RecD; pfam05127 362663007663 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 362663007664 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 362663007665 Predicted metalloprotease [General function prediction only]; Region: COG2321 362663007666 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 362663007667 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 362663007668 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 362663007669 ATP binding site [chemical binding]; other site 362663007670 active site 362663007671 substrate binding site [chemical binding]; other site 362663007672 lipoprotein; Provisional; Region: PRK11679 362663007673 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 362663007674 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 362663007675 dihydrodipicolinate synthase; Region: dapA; TIGR00674 362663007676 dimer interface [polypeptide binding]; other site 362663007677 active site 362663007678 catalytic residue [active] 362663007679 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 362663007680 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 362663007681 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 362663007682 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 362663007683 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 362663007684 catalytic triad [active] 362663007685 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 362663007686 Domain of unknown function DUF20; Region: UPF0118; pfam01594 362663007687 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 362663007688 Peptidase family M48; Region: Peptidase_M48; cl12018 362663007689 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 362663007690 ArsC family; Region: ArsC; pfam03960 362663007691 catalytic residues [active] 362663007692 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 362663007693 DNA replication initiation factor; Provisional; Region: PRK08084 362663007694 uracil transporter; Provisional; Region: PRK10720 362663007695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663007696 active site 362663007697 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 362663007698 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 362663007699 dimerization interface [polypeptide binding]; other site 362663007700 putative ATP binding site [chemical binding]; other site 362663007701 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 362663007702 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 362663007703 active site 362663007704 substrate binding site [chemical binding]; other site 362663007705 cosubstrate binding site; other site 362663007706 catalytic site [active] 362663007707 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 362663007708 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 362663007709 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 362663007710 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 362663007711 domain interface [polypeptide binding]; other site 362663007712 active site 362663007713 catalytic site [active] 362663007714 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 362663007715 putative active site [active] 362663007716 catalytic site [active] 362663007717 exopolyphosphatase; Provisional; Region: PRK10854 362663007718 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 362663007719 MASE1; Region: MASE1; pfam05231 362663007720 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 362663007721 diguanylate cyclase; Region: GGDEF; smart00267 362663007722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663007723 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 362663007724 GMP synthase; Reviewed; Region: guaA; PRK00074 362663007725 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 362663007726 AMP/PPi binding site [chemical binding]; other site 362663007727 candidate oxyanion hole; other site 362663007728 catalytic triad [active] 362663007729 potential glutamine specificity residues [chemical binding]; other site 362663007730 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 362663007731 ATP Binding subdomain [chemical binding]; other site 362663007732 Ligand Binding sites [chemical binding]; other site 362663007733 Dimerization subdomain; other site 362663007734 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 362663007735 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 362663007736 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 362663007737 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 362663007738 active site 362663007739 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 362663007740 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 362663007741 generic binding surface II; other site 362663007742 generic binding surface I; other site 362663007743 RatA-like protein; Provisional; Region: PRK15316 362663007744 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007745 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007746 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007747 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007748 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007749 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007750 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007751 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007752 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007753 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007754 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007755 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007756 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007757 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007758 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007759 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007760 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 362663007761 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 362663007762 intimin-like protein SinH; Provisional; Region: PRK15318 362663007763 intimin-like protein SinH; Provisional; Region: PRK15318 362663007764 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 362663007765 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 362663007766 GTP-binding protein Der; Reviewed; Region: PRK00093 362663007767 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 362663007768 G1 box; other site 362663007769 GTP/Mg2+ binding site [chemical binding]; other site 362663007770 Switch I region; other site 362663007771 G2 box; other site 362663007772 Switch II region; other site 362663007773 G3 box; other site 362663007774 G4 box; other site 362663007775 G5 box; other site 362663007776 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 362663007777 G1 box; other site 362663007778 GTP/Mg2+ binding site [chemical binding]; other site 362663007779 Switch I region; other site 362663007780 G2 box; other site 362663007781 G3 box; other site 362663007782 Switch II region; other site 362663007783 G4 box; other site 362663007784 G5 box; other site 362663007785 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 362663007786 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 362663007787 Trp docking motif [polypeptide binding]; other site 362663007788 active site 362663007789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 362663007790 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 362663007791 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 362663007792 dimer interface [polypeptide binding]; other site 362663007793 motif 1; other site 362663007794 active site 362663007795 motif 2; other site 362663007796 motif 3; other site 362663007797 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 362663007798 anticodon binding site; other site 362663007799 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 362663007800 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 362663007801 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 362663007802 cytoskeletal protein RodZ; Provisional; Region: PRK10856 362663007803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663007804 non-specific DNA binding site [nucleotide binding]; other site 362663007805 salt bridge; other site 362663007806 sequence-specific DNA binding site [nucleotide binding]; other site 362663007807 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 362663007808 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 362663007809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663007810 FeS/SAM binding site; other site 362663007811 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 362663007812 active site 362663007813 multimer interface [polypeptide binding]; other site 362663007814 penicillin-binding protein 1C; Provisional; Region: PRK11240 362663007815 Transglycosylase; Region: Transgly; pfam00912 362663007816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 362663007817 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 362663007818 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 362663007819 MG2 domain; Region: A2M_N; pfam01835 362663007820 Alpha-2-macroglobulin family; Region: A2M; pfam00207 362663007821 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 362663007822 surface patch; other site 362663007823 thioester region; other site 362663007824 specificity defining residues; other site 362663007825 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 362663007826 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 362663007827 active site residue [active] 362663007828 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 362663007829 active site residue [active] 362663007830 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 362663007831 aminopeptidase B; Provisional; Region: PRK05015 362663007832 Peptidase; Region: DUF3663; pfam12404 362663007833 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 362663007834 interface (dimer of trimers) [polypeptide binding]; other site 362663007835 Substrate-binding/catalytic site; other site 362663007836 Zn-binding sites [ion binding]; other site 362663007837 hypothetical protein; Provisional; Region: PRK10721 362663007838 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 362663007839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663007840 catalytic loop [active] 362663007841 iron binding site [ion binding]; other site 362663007842 chaperone protein HscA; Provisional; Region: hscA; PRK05183 362663007843 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 362663007844 nucleotide binding site [chemical binding]; other site 362663007845 putative NEF/HSP70 interaction site [polypeptide binding]; other site 362663007846 SBD interface [polypeptide binding]; other site 362663007847 co-chaperone HscB; Provisional; Region: hscB; PRK05014 362663007848 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 362663007849 HSP70 interaction site [polypeptide binding]; other site 362663007850 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 362663007851 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 362663007852 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 362663007853 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 362663007854 trimerization site [polypeptide binding]; other site 362663007855 active site 362663007856 cysteine desulfurase; Provisional; Region: PRK14012 362663007857 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 362663007858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663007859 catalytic residue [active] 362663007860 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 362663007861 Rrf2 family protein; Region: rrf2_super; TIGR00738 362663007862 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 362663007863 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 362663007864 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 362663007865 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 362663007866 active site 362663007867 dimerization interface [polypeptide binding]; other site 362663007868 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 362663007869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 362663007870 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 362663007871 PRD domain; Region: PRD; pfam00874 362663007872 PRD domain; Region: PRD; pfam00874 362663007873 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 362663007874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663007875 putative substrate translocation pore; other site 362663007876 Predicted membrane protein [Function unknown]; Region: COG2259 362663007877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663007878 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663007879 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663007880 Integrase core domain; Region: rve; pfam00665 362663007881 Integrase core domain; Region: rve_2; pfam13333 362663007882 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 362663007883 active site 362663007884 catalytic residues [active] 362663007885 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663007886 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 362663007887 putative NAD(P) binding site [chemical binding]; other site 362663007888 catalytic Zn binding site [ion binding]; other site 362663007889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663007890 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663007891 TM-ABC transporter signature motif; other site 362663007892 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 362663007893 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663007894 Walker A/P-loop; other site 362663007895 ATP binding site [chemical binding]; other site 362663007896 Q-loop/lid; other site 362663007897 ABC transporter signature motif; other site 362663007898 Walker B; other site 362663007899 D-loop; other site 362663007900 H-loop/switch region; other site 362663007901 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663007902 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 362663007903 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 362663007904 ligand binding site [chemical binding]; other site 362663007905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663007906 TPR motif; other site 362663007907 Tetratricopeptide repeat; Region: TPR_16; pfam13432 362663007908 binding surface 362663007909 TPR repeat; Region: TPR_11; pfam13414 362663007910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663007911 TPR motif; other site 362663007912 binding surface 362663007913 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 362663007914 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 362663007915 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663007916 nucleotide binding site [chemical binding]; other site 362663007917 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 362663007918 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 362663007919 dimer interface [polypeptide binding]; other site 362663007920 active site 362663007921 glycine-pyridoxal phosphate binding site [chemical binding]; other site 362663007922 folate binding site [chemical binding]; other site 362663007923 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 362663007924 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 362663007925 heme-binding site [chemical binding]; other site 362663007926 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 362663007927 FAD binding pocket [chemical binding]; other site 362663007928 FAD binding motif [chemical binding]; other site 362663007929 phosphate binding motif [ion binding]; other site 362663007930 beta-alpha-beta structure motif; other site 362663007931 NAD binding pocket [chemical binding]; other site 362663007932 Heme binding pocket [chemical binding]; other site 362663007933 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 362663007934 Nitrogen regulatory protein P-II; Region: P-II; smart00938 362663007935 response regulator GlrR; Provisional; Region: PRK15115 362663007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663007937 active site 362663007938 phosphorylation site [posttranslational modification] 362663007939 intermolecular recognition site; other site 362663007940 dimerization interface [polypeptide binding]; other site 362663007941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663007942 Walker A motif; other site 362663007943 ATP binding site [chemical binding]; other site 362663007944 Walker B motif; other site 362663007945 arginine finger; other site 362663007946 hypothetical protein; Provisional; Region: PRK10722 362663007947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 362663007948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663007949 dimer interface [polypeptide binding]; other site 362663007950 phosphorylation site [posttranslational modification] 362663007951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663007952 ATP binding site [chemical binding]; other site 362663007953 Mg2+ binding site [ion binding]; other site 362663007954 G-X-G motif; other site 362663007955 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 362663007956 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 362663007957 dimerization interface [polypeptide binding]; other site 362663007958 ATP binding site [chemical binding]; other site 362663007959 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 362663007960 dimerization interface [polypeptide binding]; other site 362663007961 ATP binding site [chemical binding]; other site 362663007962 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 362663007963 putative active site [active] 362663007964 catalytic triad [active] 362663007965 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 362663007966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663007967 substrate binding pocket [chemical binding]; other site 362663007968 membrane-bound complex binding site; other site 362663007969 hinge residues; other site 362663007970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663007971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663007972 catalytic residue [active] 362663007973 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 362663007974 nucleoside/Zn binding site; other site 362663007975 dimer interface [polypeptide binding]; other site 362663007976 catalytic motif [active] 362663007977 hypothetical protein; Provisional; Region: PRK11590 362663007978 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 362663007979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362663007980 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 362663007981 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362663007982 putative active site [active] 362663007983 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 362663007984 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 362663007985 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 362663007986 active site 362663007987 hydrophilic channel; other site 362663007988 dimerization interface [polypeptide binding]; other site 362663007989 catalytic residues [active] 362663007990 active site lid [active] 362663007991 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 362663007992 Recombination protein O N terminal; Region: RecO_N; pfam11967 362663007993 Recombination protein O C terminal; Region: RecO_C; pfam02565 362663007994 GTPase Era; Reviewed; Region: era; PRK00089 362663007995 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 362663007996 G1 box; other site 362663007997 GTP/Mg2+ binding site [chemical binding]; other site 362663007998 Switch I region; other site 362663007999 G2 box; other site 362663008000 Switch II region; other site 362663008001 G3 box; other site 362663008002 G4 box; other site 362663008003 G5 box; other site 362663008004 KH domain; Region: KH_2; pfam07650 362663008005 ribonuclease III; Reviewed; Region: rnc; PRK00102 362663008006 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 362663008007 dimerization interface [polypeptide binding]; other site 362663008008 active site 362663008009 metal binding site [ion binding]; metal-binding site 362663008010 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 362663008011 dsRNA binding site [nucleotide binding]; other site 362663008012 signal peptidase I; Provisional; Region: PRK10861 362663008013 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 362663008014 Catalytic site [active] 362663008015 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 362663008016 GTP-binding protein LepA; Provisional; Region: PRK05433 362663008017 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 362663008018 G1 box; other site 362663008019 putative GEF interaction site [polypeptide binding]; other site 362663008020 GTP/Mg2+ binding site [chemical binding]; other site 362663008021 Switch I region; other site 362663008022 G2 box; other site 362663008023 G3 box; other site 362663008024 Switch II region; other site 362663008025 G4 box; other site 362663008026 G5 box; other site 362663008027 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 362663008028 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 362663008029 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 362663008030 SoxR reducing system protein RseC; Provisional; Region: PRK10862 362663008031 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 362663008032 anti-sigma E factor; Provisional; Region: rseB; PRK09455 362663008033 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 362663008034 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 362663008035 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 362663008036 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 362663008037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362663008038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362663008039 DNA binding residues [nucleotide binding] 362663008040 L-aspartate oxidase; Provisional; Region: PRK09077 362663008041 L-aspartate oxidase; Provisional; Region: PRK06175 362663008042 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 362663008043 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 362663008044 Methyltransferase domain; Region: Methyltransf_26; pfam13659 362663008045 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 362663008046 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362663008047 ATP binding site [chemical binding]; other site 362663008048 Mg++ binding site [ion binding]; other site 362663008049 motif III; other site 362663008050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663008051 nucleotide binding region [chemical binding]; other site 362663008052 ATP-binding site [chemical binding]; other site 362663008053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663008054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663008055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 362663008056 dimerization interface [polypeptide binding]; other site 362663008057 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 362663008058 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 362663008059 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 362663008060 ligand binding site [chemical binding]; other site 362663008061 active site 362663008062 UGI interface [polypeptide binding]; other site 362663008063 catalytic site [active] 362663008064 putative methyltransferase; Provisional; Region: PRK10864 362663008065 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 362663008066 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 362663008067 thioredoxin 2; Provisional; Region: PRK10996 362663008068 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 362663008069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362663008070 catalytic residues [active] 362663008071 Uncharacterized conserved protein [Function unknown]; Region: COG3148 362663008072 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 362663008073 CoA binding domain; Region: CoA_binding_2; pfam13380 362663008074 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 362663008075 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 362663008076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 362663008077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 362663008078 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 362663008079 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 362663008080 domain interface [polypeptide binding]; other site 362663008081 putative active site [active] 362663008082 catalytic site [active] 362663008083 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 362663008084 domain interface [polypeptide binding]; other site 362663008085 putative active site [active] 362663008086 catalytic site [active] 362663008087 lipoprotein; Provisional; Region: PRK10759 362663008088 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 362663008089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008090 putative substrate translocation pore; other site 362663008091 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663008092 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663008093 Transposase; Region: DEDD_Tnp_IS110; pfam01548 362663008094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663008095 Integrase core domain; Region: rve; pfam00665 362663008096 Integrase core domain; Region: rve_2; pfam13333 362663008097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663008098 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663008099 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663008100 protein disaggregation chaperone; Provisional; Region: PRK10865 362663008101 Clp amino terminal domain; Region: Clp_N; pfam02861 362663008102 Clp amino terminal domain; Region: Clp_N; pfam02861 362663008103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008104 Walker A motif; other site 362663008105 ATP binding site [chemical binding]; other site 362663008106 Walker B motif; other site 362663008107 arginine finger; other site 362663008108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008109 Walker A motif; other site 362663008110 ATP binding site [chemical binding]; other site 362663008111 Walker B motif; other site 362663008112 arginine finger; other site 362663008113 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362663008114 hypothetical protein; Provisional; Region: PRK10723 362663008115 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 362663008116 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 362663008117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663008118 RNA binding surface [nucleotide binding]; other site 362663008119 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 362663008120 active site 362663008121 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 362663008122 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 362663008123 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 362663008124 30S subunit binding site; other site 362663008125 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 362663008126 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 362663008127 Prephenate dehydratase; Region: PDT; pfam00800 362663008128 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 362663008129 putative L-Phe binding site [chemical binding]; other site 362663008130 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 362663008131 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 362663008132 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 362663008133 prephenate dehydrogenase; Validated; Region: PRK08507 362663008134 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 362663008135 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 362663008136 lipoprotein; Provisional; Region: PRK11443 362663008137 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 362663008138 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 362663008139 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 362663008140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663008141 metal binding site [ion binding]; metal-binding site 362663008142 active site 362663008143 I-site; other site 362663008144 putative outer membrane lipoprotein; Provisional; Region: PRK09967 362663008145 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663008146 ligand binding site [chemical binding]; other site 362663008147 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 362663008148 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 362663008149 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 362663008150 RimM N-terminal domain; Region: RimM; pfam01782 362663008151 PRC-barrel domain; Region: PRC; pfam05239 362663008152 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 362663008153 signal recognition particle protein; Provisional; Region: PRK10867 362663008154 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 362663008155 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 362663008156 P loop; other site 362663008157 GTP binding site [chemical binding]; other site 362663008158 Signal peptide binding domain; Region: SRP_SPB; pfam02978 362663008159 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 362663008160 hypothetical protein; Provisional; Region: PRK11573 362663008161 Domain of unknown function DUF21; Region: DUF21; pfam01595 362663008162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362663008163 Transporter associated domain; Region: CorC_HlyC; smart01091 362663008164 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 362663008165 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 362663008166 dimer interface [polypeptide binding]; other site 362663008167 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 362663008168 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 362663008169 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 362663008170 recombination and repair protein; Provisional; Region: PRK10869 362663008171 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 362663008172 Walker A/P-loop; other site 362663008173 ATP binding site [chemical binding]; other site 362663008174 Q-loop/lid; other site 362663008175 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 362663008176 Q-loop/lid; other site 362663008177 ABC transporter signature motif; other site 362663008178 Walker B; other site 362663008179 D-loop; other site 362663008180 H-loop/switch region; other site 362663008181 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 362663008182 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 362663008183 hypothetical protein; Validated; Region: PRK01777 362663008184 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 362663008185 putative coenzyme Q binding site [chemical binding]; other site 362663008186 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 362663008187 SmpB-tmRNA interface; other site 362663008188 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 362663008189 substrate binding pocket [chemical binding]; other site 362663008190 active site 362663008191 iron coordination sites [ion binding]; other site 362663008192 Predicted dehydrogenase [General function prediction only]; Region: COG0579 362663008193 hydroxyglutarate oxidase; Provisional; Region: PRK11728 362663008194 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 362663008195 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 362663008196 tetramerization interface [polypeptide binding]; other site 362663008197 NAD(P) binding site [chemical binding]; other site 362663008198 catalytic residues [active] 362663008199 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 362663008200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663008201 inhibitor-cofactor binding pocket; inhibition site 362663008202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663008203 catalytic residue [active] 362663008204 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 362663008205 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 362663008206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663008207 DNA-binding site [nucleotide binding]; DNA binding site 362663008208 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663008209 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 362663008210 bacterial OsmY and nodulation domain; Region: BON; smart00749 362663008211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663008212 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 362663008213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663008214 dimerization interface [polypeptide binding]; other site 362663008215 putative DNA binding site [nucleotide binding]; other site 362663008216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 362663008217 putative Zn2+ binding site [ion binding]; other site 362663008218 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 362663008219 active site residue [active] 362663008220 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 362663008221 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 362663008222 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 362663008223 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 362663008224 hypothetical protein; Provisional; Region: PRK10556 362663008225 hypothetical protein; Provisional; Region: PRK10132 362663008226 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 362663008227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663008228 DNA-binding site [nucleotide binding]; DNA binding site 362663008229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663008230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663008231 homodimer interface [polypeptide binding]; other site 362663008232 catalytic residue [active] 362663008233 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 362663008234 Uncharacterized conserved protein [Function unknown]; Region: COG2128 362663008235 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 362663008236 catalytic residues [active] 362663008237 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 362663008238 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 362663008239 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 362663008240 Class I ribonucleotide reductase; Region: RNR_I; cd01679 362663008241 active site 362663008242 dimer interface [polypeptide binding]; other site 362663008243 catalytic residues [active] 362663008244 effector binding site; other site 362663008245 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 362663008246 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 362663008247 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 362663008248 dimer interface [polypeptide binding]; other site 362663008249 putative radical transfer pathway; other site 362663008250 diiron center [ion binding]; other site 362663008251 tyrosyl radical; other site 362663008252 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 362663008253 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 362663008254 Walker A/P-loop; other site 362663008255 ATP binding site [chemical binding]; other site 362663008256 Q-loop/lid; other site 362663008257 ABC transporter signature motif; other site 362663008258 Walker B; other site 362663008259 D-loop; other site 362663008260 H-loop/switch region; other site 362663008261 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 362663008262 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 362663008263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663008264 dimer interface [polypeptide binding]; other site 362663008265 conserved gate region; other site 362663008266 putative PBP binding loops; other site 362663008267 ABC-ATPase subunit interface; other site 362663008268 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 362663008269 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 362663008270 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 362663008271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008272 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 362663008273 putative L-valine exporter; Provisional; Region: PRK10408 362663008274 transcriptional repressor MprA; Provisional; Region: PRK10870 362663008275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663008276 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 362663008277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663008278 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663008279 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 362663008280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008281 putative substrate translocation pore; other site 362663008282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008283 S-ribosylhomocysteinase; Provisional; Region: PRK02260 362663008284 glutamate--cysteine ligase; Provisional; Region: PRK02107 362663008285 Predicted membrane protein [Function unknown]; Region: COG1238 362663008286 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 362663008287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663008288 motif II; other site 362663008289 carbon storage regulator; Provisional; Region: PRK01712 362663008290 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 362663008291 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 362663008292 motif 1; other site 362663008293 active site 362663008294 motif 2; other site 362663008295 motif 3; other site 362663008296 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 362663008297 DHHA1 domain; Region: DHHA1; pfam02272 362663008298 recombination regulator RecX; Reviewed; Region: recX; PRK00117 362663008299 recombinase A; Provisional; Region: recA; PRK09354 362663008300 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 362663008301 hexamer interface [polypeptide binding]; other site 362663008302 Walker A motif; other site 362663008303 ATP binding site [chemical binding]; other site 362663008304 Walker B motif; other site 362663008305 hypothetical protein; Validated; Region: PRK03661 362663008306 Transglycosylase SLT domain; Region: SLT_2; pfam13406 362663008307 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663008308 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663008309 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 362663008310 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 362663008311 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 362663008312 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 362663008313 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 362663008314 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 362663008315 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 362663008316 putative NAD(P) binding site [chemical binding]; other site 362663008317 active site 362663008318 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 362663008319 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 362663008320 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 362663008321 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663008322 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 362663008323 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 362663008324 putative active site [active] 362663008325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 362663008326 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 362663008327 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 362663008328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008329 Walker A motif; other site 362663008330 ATP binding site [chemical binding]; other site 362663008331 Walker B motif; other site 362663008332 arginine finger; other site 362663008333 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 362663008334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 362663008335 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 362663008336 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 362663008337 iron binding site [ion binding]; other site 362663008338 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 362663008339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663008340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663008341 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 362663008342 Acylphosphatase; Region: Acylphosphatase; pfam00708 362663008343 HypF finger; Region: zf-HYPF; pfam07503 362663008344 HypF finger; Region: zf-HYPF; pfam07503 362663008345 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 362663008346 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 362663008347 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 362663008348 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362663008349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663008350 DNA binding site [nucleotide binding] 362663008351 domain linker motif; other site 362663008352 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 362663008353 dimerization interface (closed form) [polypeptide binding]; other site 362663008354 ligand binding site [chemical binding]; other site 362663008355 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 362663008356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663008357 active site turn [active] 362663008358 phosphorylation site [posttranslational modification] 362663008359 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 362663008360 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 362663008361 beta-galactosidase; Region: BGL; TIGR03356 362663008362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663008363 non-specific DNA binding site [nucleotide binding]; other site 362663008364 salt bridge; other site 362663008365 sequence-specific DNA binding site [nucleotide binding]; other site 362663008366 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 362663008367 nickel binding site [ion binding]; other site 362663008368 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 362663008369 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 362663008370 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 362663008371 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663008372 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 362663008373 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 362663008374 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 362663008375 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 362663008376 NADH dehydrogenase; Region: NADHdh; cl00469 362663008377 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 362663008378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 362663008379 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 362663008380 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 362663008381 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 362663008382 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 362663008383 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 362663008384 hydrogenase assembly chaperone; Provisional; Region: PRK10409 362663008385 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 362663008386 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 362663008387 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 362663008388 dimerization interface [polypeptide binding]; other site 362663008389 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 362663008390 ATP binding site [chemical binding]; other site 362663008391 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 362663008392 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 362663008393 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 362663008394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008395 Walker A motif; other site 362663008396 ATP binding site [chemical binding]; other site 362663008397 Walker B motif; other site 362663008398 arginine finger; other site 362663008399 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 362663008400 molybdenum-pterin binding domain; Region: Mop; TIGR00638 362663008401 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 362663008402 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 362663008403 Homeodomain-like domain; Region: HTH_23; pfam13384 362663008404 Winged helix-turn helix; Region: HTH_29; pfam13551 362663008405 Winged helix-turn helix; Region: HTH_33; pfam13592 362663008406 DDE superfamily endonuclease; Region: DDE_3; pfam13358 362663008407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 362663008408 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 362663008409 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 362663008410 putative active site [active] 362663008411 putative NTP binding site [chemical binding]; other site 362663008412 putative nucleic acid binding site [nucleotide binding]; other site 362663008413 transposase/IS protein; Provisional; Region: PRK09183 362663008414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008415 Walker A motif; other site 362663008416 ATP binding site [chemical binding]; other site 362663008417 Walker B motif; other site 362663008418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663008419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663008420 Transposase; Region: HTH_Tnp_1; pfam01527 362663008421 putative transposase OrfB; Reviewed; Region: PHA02517 362663008422 HTH-like domain; Region: HTH_21; pfam13276 362663008423 Integrase core domain; Region: rve; pfam00665 362663008424 Integrase core domain; Region: rve_3; pfam13683 362663008425 Helix-turn-helix domain; Region: HTH_38; pfam13936 362663008426 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 362663008427 Integrase core domain; Region: rve; pfam00665 362663008428 AAA domain; Region: AAA_22; pfam13401 362663008429 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663008430 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 362663008431 MutS domain I; Region: MutS_I; pfam01624 362663008432 MutS domain II; Region: MutS_II; pfam05188 362663008433 MutS domain III; Region: MutS_III; pfam05192 362663008434 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 362663008435 Walker A/P-loop; other site 362663008436 ATP binding site [chemical binding]; other site 362663008437 Q-loop/lid; other site 362663008438 ABC transporter signature motif; other site 362663008439 Walker B; other site 362663008440 D-loop; other site 362663008441 H-loop/switch region; other site 362663008442 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 362663008443 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 362663008444 active site 362663008445 metal binding site [ion binding]; metal-binding site 362663008446 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663008447 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663008448 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663008449 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 362663008450 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 362663008451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 362663008452 putative aldolase; Validated; Region: PRK08130 362663008453 active site 362663008454 intersubunit interface [polypeptide binding]; other site 362663008455 Zn2+ binding site [ion binding]; other site 362663008456 hypothetical protein; Provisional; Region: PRK09989 362663008457 fructuronate transporter; Provisional; Region: PRK10034; cl15264 362663008458 fructuronate transporter; Provisional; Region: PRK10034; cl15264 362663008459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 362663008460 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 362663008461 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362663008462 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 362663008463 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 362663008464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362663008465 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 362663008466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362663008467 DNA binding residues [nucleotide binding] 362663008468 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 362663008469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663008470 Peptidase family M23; Region: Peptidase_M23; pfam01551 362663008471 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 362663008472 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 362663008473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 362663008474 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 362663008475 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 362663008476 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 362663008477 Permutation of conserved domain; other site 362663008478 active site 362663008479 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 362663008480 homotrimer interaction site [polypeptide binding]; other site 362663008481 zinc binding site [ion binding]; other site 362663008482 CDP-binding sites; other site 362663008483 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 362663008484 substrate binding site; other site 362663008485 dimer interface; other site 362663008486 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 362663008487 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 362663008488 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 362663008489 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 362663008490 ligand-binding site [chemical binding]; other site 362663008491 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 362663008492 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 362663008493 CysD dimerization site [polypeptide binding]; other site 362663008494 G1 box; other site 362663008495 putative GEF interaction site [polypeptide binding]; other site 362663008496 GTP/Mg2+ binding site [chemical binding]; other site 362663008497 Switch I region; other site 362663008498 G2 box; other site 362663008499 G3 box; other site 362663008500 Switch II region; other site 362663008501 G4 box; other site 362663008502 G5 box; other site 362663008503 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 362663008504 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 362663008505 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 362663008506 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 362663008507 Active Sites [active] 362663008508 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 362663008509 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 362663008510 metal binding site [ion binding]; metal-binding site 362663008511 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 362663008512 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 362663008513 Active Sites [active] 362663008514 sulfite reductase subunit beta; Provisional; Region: PRK13504 362663008515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 362663008516 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 362663008517 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 362663008518 Flavodoxin; Region: Flavodoxin_1; pfam00258 362663008519 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 362663008520 FAD binding pocket [chemical binding]; other site 362663008521 FAD binding motif [chemical binding]; other site 362663008522 catalytic residues [active] 362663008523 NAD binding pocket [chemical binding]; other site 362663008524 phosphate binding motif [ion binding]; other site 362663008525 beta-alpha-beta structure motif; other site 362663008526 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 362663008527 active site 362663008528 putative oxidoreductase FixC; Provisional; Region: PRK10157 362663008529 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 362663008530 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 362663008531 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 362663008532 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 362663008533 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 362663008534 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 362663008535 Ligand binding site [chemical binding]; other site 362663008536 Electron transfer flavoprotein domain; Region: ETF; pfam01012 362663008537 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 362663008538 benzoate transport; Region: 2A0115; TIGR00895 362663008539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008540 putative substrate translocation pore; other site 362663008541 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 362663008542 FAD binding domain; Region: FAD_binding_4; pfam01565 362663008543 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 362663008544 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 362663008545 NADP binding site [chemical binding]; other site 362663008546 homodimer interface [polypeptide binding]; other site 362663008547 active site 362663008548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 362663008549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008550 putative substrate translocation pore; other site 362663008551 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 362663008552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 362663008553 nucleotide binding site [chemical binding]; other site 362663008554 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663008555 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 362663008556 putative substrate binding site [chemical binding]; other site 362663008557 putative ATP binding site [chemical binding]; other site 362663008558 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 362663008559 trimer interface; other site 362663008560 sugar binding site [chemical binding]; other site 362663008561 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 362663008562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663008563 active site turn [active] 362663008564 phosphorylation site [posttranslational modification] 362663008565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663008566 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 362663008567 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 362663008568 substrate binding [chemical binding]; other site 362663008569 active site 362663008570 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 362663008571 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 362663008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663008573 DNA binding site [nucleotide binding] 362663008574 domain linker motif; other site 362663008575 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 362663008576 dimerization interface [polypeptide binding]; other site 362663008577 ligand binding site [chemical binding]; other site 362663008578 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 362663008579 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 362663008580 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 362663008581 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 362663008582 Repair protein; Region: Repair_PSII; pfam04536 362663008583 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 362663008584 Repair protein; Region: Repair_PSII; pfam04536 362663008585 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 362663008586 Repair protein; Region: Repair_PSII; pfam04536 362663008587 enolase; Provisional; Region: eno; PRK00077 362663008588 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 362663008589 dimer interface [polypeptide binding]; other site 362663008590 metal binding site [ion binding]; metal-binding site 362663008591 substrate binding pocket [chemical binding]; other site 362663008592 CTP synthetase; Validated; Region: pyrG; PRK05380 362663008593 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 362663008594 Catalytic site [active] 362663008595 active site 362663008596 UTP binding site [chemical binding]; other site 362663008597 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 362663008598 active site 362663008599 putative oxyanion hole; other site 362663008600 catalytic triad [active] 362663008601 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 362663008602 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 362663008603 homodimer interface [polypeptide binding]; other site 362663008604 metal binding site [ion binding]; metal-binding site 362663008605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 362663008606 homodimer interface [polypeptide binding]; other site 362663008607 active site 362663008608 putative chemical substrate binding site [chemical binding]; other site 362663008609 metal binding site [ion binding]; metal-binding site 362663008610 toxin MazF; Provisional; Region: PRK09907 362663008611 antitoxin MazE; Provisional; Region: PRK09798 362663008612 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 362663008613 HD domain; Region: HD_4; pfam13328 362663008614 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 362663008615 synthetase active site [active] 362663008616 NTP binding site [chemical binding]; other site 362663008617 metal binding site [ion binding]; metal-binding site 362663008618 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 362663008619 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 362663008620 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 362663008621 TRAM domain; Region: TRAM; pfam01938 362663008622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663008623 S-adenosylmethionine binding site [chemical binding]; other site 362663008624 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 362663008625 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 362663008626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663008627 dimerization interface [polypeptide binding]; other site 362663008628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663008629 dimer interface [polypeptide binding]; other site 362663008630 phosphorylation site [posttranslational modification] 362663008631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663008632 ATP binding site [chemical binding]; other site 362663008633 Mg2+ binding site [ion binding]; other site 362663008634 G-X-G motif; other site 362663008635 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 362663008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663008637 active site 362663008638 phosphorylation site [posttranslational modification] 362663008639 intermolecular recognition site; other site 362663008640 dimerization interface [polypeptide binding]; other site 362663008641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663008642 putative binding surface; other site 362663008643 active site 362663008644 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 362663008645 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 362663008646 active site 362663008647 tetramer interface [polypeptide binding]; other site 362663008648 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 362663008649 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 362663008650 active site 362663008651 tetramer interface [polypeptide binding]; other site 362663008652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008653 D-galactonate transporter; Region: 2A0114; TIGR00893 362663008654 putative substrate translocation pore; other site 362663008655 flavodoxin; Provisional; Region: PRK08105 362663008656 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 362663008657 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 362663008658 probable active site [active] 362663008659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 362663008660 SecY interacting protein Syd; Provisional; Region: PRK04968 362663008661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 362663008662 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 362663008663 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 362663008664 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 362663008665 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 362663008666 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 362663008667 serine transporter; Region: stp; TIGR00814 362663008668 L-serine dehydratase nonfunction due to the frame shift 362663008669 L-serine dehydratase nonfunction due to the frame shift 362663008670 flap endonuclease-like protein; Provisional; Region: PRK09482 362663008671 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 362663008672 active site 362663008673 metal binding site 1 [ion binding]; metal-binding site 362663008674 putative 5' ssDNA interaction site; other site 362663008675 metal binding site 3; metal-binding site 362663008676 metal binding site 2 [ion binding]; metal-binding site 362663008677 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 362663008678 putative DNA binding site [nucleotide binding]; other site 362663008679 putative metal binding site [ion binding]; other site 362663008680 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 362663008681 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 362663008682 dimer interface [polypeptide binding]; other site 362663008683 active site 362663008684 metal binding site [ion binding]; metal-binding site 362663008685 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 362663008686 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 362663008687 intersubunit interface [polypeptide binding]; other site 362663008688 active site 362663008689 Zn2+ binding site [ion binding]; other site 362663008690 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 362663008691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008692 putative substrate translocation pore; other site 362663008693 L-fucose isomerase; Provisional; Region: fucI; PRK10991 362663008694 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 362663008695 hexamer (dimer of trimers) interface [polypeptide binding]; other site 362663008696 trimer interface [polypeptide binding]; other site 362663008697 substrate binding site [chemical binding]; other site 362663008698 Mn binding site [ion binding]; other site 362663008699 L-fuculokinase; Provisional; Region: PRK10331 362663008700 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 362663008701 nucleotide binding site [chemical binding]; other site 362663008702 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 362663008703 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663008704 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 362663008705 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 362663008706 hypothetical protein; Provisional; Region: PRK10873 362663008707 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 362663008708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663008709 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 362663008710 dimerization interface [polypeptide binding]; other site 362663008711 substrate binding pocket [chemical binding]; other site 362663008712 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 362663008713 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 362663008714 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 362663008715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663008716 catalytic residue [active] 362663008717 CsdA-binding activator; Provisional; Region: PRK15019 362663008718 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 362663008719 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 362663008720 putative ATP binding site [chemical binding]; other site 362663008721 putative substrate interface [chemical binding]; other site 362663008722 murein transglycosylase A; Provisional; Region: mltA; PRK11162 362663008723 MltA specific insert domain; Region: MltA; pfam03562 362663008724 3D domain; Region: 3D; pfam06725 362663008725 Protein of unknown function (DUF770); Region: DUF770; pfam05591 362663008726 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 362663008727 Protein of unknown function (DUF877); Region: DUF877; pfam05943 362663008728 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 362663008729 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 362663008730 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 362663008731 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 362663008732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663008733 ligand binding site [chemical binding]; other site 362663008734 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 362663008735 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 362663008736 Clp amino terminal domain; Region: Clp_N; pfam02861 362663008737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008738 Walker A motif; other site 362663008739 ATP binding site [chemical binding]; other site 362663008740 Walker B motif; other site 362663008741 arginine finger; other site 362663008742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008743 Walker A motif; other site 362663008744 ATP binding site [chemical binding]; other site 362663008745 Walker B motif; other site 362663008746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 362663008747 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 362663008748 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 362663008749 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 362663008750 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 362663008751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 362663008752 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 362663008753 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 362663008754 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 362663008755 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 362663008756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 362663008757 Peptidase M35 family; Region: M35_like; cl03449 362663008758 active site 362663008759 Zn binding site [ion binding]; other site 362663008760 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 362663008761 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 362663008762 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 362663008763 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 362663008764 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 362663008765 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 362663008766 PAAR motif; Region: PAAR_motif; pfam05488 362663008767 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 362663008768 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 362663008769 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 362663008770 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 362663008771 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 362663008772 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 362663008773 ImpA domain protein; Region: DUF3702; pfam12486 362663008774 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 362663008775 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 362663008776 putative ligand binding site [chemical binding]; other site 362663008777 putative NAD binding site [chemical binding]; other site 362663008778 catalytic site [active] 362663008779 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 362663008780 putative active site [active] 362663008781 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 362663008782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663008783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663008784 homodimer interface [polypeptide binding]; other site 362663008785 catalytic residue [active] 362663008786 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 362663008787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663008788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663008789 active site turn [active] 362663008790 phosphorylation site [posttranslational modification] 362663008791 CAT RNA binding domain; Region: CAT_RBD; pfam03123 362663008792 PRD domain; Region: PRD; pfam00874 362663008793 PRD domain; Region: PRD; pfam00874 362663008794 AMIN domain; Region: AMIN; pfam11741 362663008795 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 362663008796 active site 362663008797 metal binding site [ion binding]; metal-binding site 362663008798 N-acetylglutamate synthase; Validated; Region: PRK05279 362663008799 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 362663008800 putative feedback inhibition sensing region; other site 362663008801 putative nucleotide binding site [chemical binding]; other site 362663008802 putative substrate binding site [chemical binding]; other site 362663008803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663008804 Coenzyme A binding pocket [chemical binding]; other site 362663008805 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 362663008806 AAA domain; Region: AAA_30; pfam13604 362663008807 Family description; Region: UvrD_C_2; pfam13538 362663008808 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 362663008809 protease3; Provisional; Region: PRK15101 362663008810 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 362663008811 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362663008812 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362663008813 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 362663008814 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 362663008815 hypothetical protein; Provisional; Region: PRK10332 362663008816 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 362663008817 hypothetical protein; Provisional; Region: PRK11521 362663008818 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 362663008819 hypothetical protein; Provisional; Region: PRK10557 362663008820 hypothetical protein; Provisional; Region: PRK10506 362663008821 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 362663008822 thymidylate synthase; Reviewed; Region: thyA; PRK01827 362663008823 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 362663008824 dimerization interface [polypeptide binding]; other site 362663008825 active site 362663008826 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 362663008827 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 362663008828 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 362663008829 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 362663008830 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663008831 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663008832 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 362663008833 putative active site [active] 362663008834 Ap4A binding site [chemical binding]; other site 362663008835 nudix motif; other site 362663008836 putative metal binding site [ion binding]; other site 362663008837 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 362663008838 putative DNA-binding cleft [nucleotide binding]; other site 362663008839 putative DNA clevage site; other site 362663008840 molecular lever; other site 362663008841 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 362663008842 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 362663008843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663008844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663008845 active site 362663008846 catalytic tetrad [active] 362663008847 lysophospholipid transporter LplT; Provisional; Region: PRK11195 362663008848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008849 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 362663008850 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 362663008851 putative acyl-acceptor binding pocket; other site 362663008852 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 362663008853 acyl-activating enzyme (AAE) consensus motif; other site 362663008854 putative AMP binding site [chemical binding]; other site 362663008855 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 362663008856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663008857 DNA binding site [nucleotide binding] 362663008858 domain linker motif; other site 362663008859 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 362663008860 dimerization interface (closed form) [polypeptide binding]; other site 362663008861 ligand binding site [chemical binding]; other site 362663008862 diaminopimelate decarboxylase; Provisional; Region: PRK11165 362663008863 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 362663008864 active site 362663008865 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663008866 substrate binding site [chemical binding]; other site 362663008867 catalytic residues [active] 362663008868 dimer interface [polypeptide binding]; other site 362663008869 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 362663008870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663008871 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 362663008872 putative dimerization interface [polypeptide binding]; other site 362663008873 putative racemase; Provisional; Region: PRK10200 362663008874 aspartate racemase; Region: asp_race; TIGR00035 362663008875 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 362663008876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008877 putative substrate translocation pore; other site 362663008878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663008879 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 362663008880 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 362663008881 NADP binding site [chemical binding]; other site 362663008882 homodimer interface [polypeptide binding]; other site 362663008883 active site 362663008884 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 362663008885 putative acyltransferase; Provisional; Region: PRK05790 362663008886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 362663008887 dimer interface [polypeptide binding]; other site 362663008888 active site 362663008889 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 362663008890 serine transporter; Region: stp; TIGR00814 362663008891 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 362663008892 Peptidase family M23; Region: Peptidase_M23; pfam01551 362663008893 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 362663008894 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 362663008895 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 362663008896 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 362663008897 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 362663008898 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 362663008899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 362663008900 catalytic loop [active] 362663008901 iron binding site [ion binding]; other site 362663008902 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 362663008903 GAF domain; Region: GAF; cl17456 362663008904 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 362663008905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663008906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663008907 Walker A motif; other site 362663008908 ATP binding site [chemical binding]; other site 362663008909 Walker B motif; other site 362663008910 arginine finger; other site 362663008911 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663008912 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 362663008913 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 362663008914 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 362663008915 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 362663008916 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 362663008917 catalytic residue [active] 362663008918 peptidase; Reviewed; Region: PRK13004 362663008919 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 362663008920 putative metal binding site [ion binding]; other site 362663008921 putative dimer interface [polypeptide binding]; other site 362663008922 D-hydantoinase; Region: D-hydantoinase; TIGR02033 362663008923 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 362663008924 tetramer interface [polypeptide binding]; other site 362663008925 active site 362663008926 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 362663008927 carbamate kinase; Reviewed; Region: PRK12686 362663008928 putative substrate binding site [chemical binding]; other site 362663008929 homodimer interface [polypeptide binding]; other site 362663008930 nucleotide binding site [chemical binding]; other site 362663008931 nucleotide binding site [chemical binding]; other site 362663008932 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 362663008933 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 362663008934 XdhC Rossmann domain; Region: XdhC_C; pfam13478 362663008935 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 362663008936 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 362663008937 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 362663008938 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 362663008939 metal-binding site 362663008940 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 362663008941 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 362663008942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663008943 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 362663008944 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 362663008945 active site 362663008946 putative substrate binding pocket [chemical binding]; other site 362663008947 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 362663008948 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 362663008949 putative hypoxanthine oxidase; Provisional; Region: PRK09800 362663008950 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 362663008951 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 362663008952 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 362663008953 uracil-xanthine permease; Region: ncs2; TIGR00801 362663008954 guanine deaminase; Provisional; Region: PRK09228 362663008955 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 362663008956 active site 362663008957 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362663008958 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 362663008959 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 362663008960 4Fe-4S binding domain; Region: Fer4; pfam00037 362663008961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 362663008962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663008963 xanthine permease; Region: pbuX; TIGR03173 362663008964 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 362663008965 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 362663008966 active site 362663008967 metal binding site [ion binding]; metal-binding site 362663008968 nudix motif; other site 362663008969 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 362663008970 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 362663008971 dimer interface [polypeptide binding]; other site 362663008972 putative anticodon binding site; other site 362663008973 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 362663008974 motif 1; other site 362663008975 active site 362663008976 motif 2; other site 362663008977 motif 3; other site 362663008978 peptide chain release factor 2; Provisional; Region: PRK08787 362663008979 This domain is found in peptide chain release factors; Region: PCRF; smart00937 362663008980 RF-1 domain; Region: RF-1; pfam00472 362663008981 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 362663008982 DHH family; Region: DHH; pfam01368 362663008983 DHHA1 domain; Region: DHHA1; pfam02272 362663008984 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 362663008985 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 362663008986 dimerization domain [polypeptide binding]; other site 362663008987 dimer interface [polypeptide binding]; other site 362663008988 catalytic residues [active] 362663008989 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 362663008990 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 362663008991 active site 362663008992 Int/Topo IB signature motif; other site 362663008993 flavodoxin FldB; Provisional; Region: PRK12359 362663008994 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 362663008995 hypothetical protein; Provisional; Region: PRK10878 362663008996 putative global regulator; Reviewed; Region: PRK09559 362663008997 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 362663008998 hemolysin; Provisional; Region: PRK15087 362663008999 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 362663009000 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 362663009001 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 362663009002 beta-galactosidase; Region: BGL; TIGR03356 362663009003 glycine dehydrogenase; Provisional; Region: PRK05367 362663009004 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 362663009005 tetramer interface [polypeptide binding]; other site 362663009006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009007 catalytic residue [active] 362663009008 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 362663009009 tetramer interface [polypeptide binding]; other site 362663009010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009011 catalytic residue [active] 362663009012 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 362663009013 lipoyl attachment site [posttranslational modification]; other site 362663009014 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 362663009015 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 362663009016 oxidoreductase; Provisional; Region: PRK08013 362663009017 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 362663009018 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 362663009019 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 362663009020 proline aminopeptidase P II; Provisional; Region: PRK10879 362663009021 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 362663009022 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 362663009023 active site 362663009024 hypothetical protein; Reviewed; Region: PRK01736 362663009025 Z-ring-associated protein; Provisional; Region: PRK10972 362663009026 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 362663009027 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 362663009028 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 362663009029 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 362663009030 ligand binding site [chemical binding]; other site 362663009031 NAD binding site [chemical binding]; other site 362663009032 tetramer interface [polypeptide binding]; other site 362663009033 catalytic site [active] 362663009034 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 362663009035 L-serine binding site [chemical binding]; other site 362663009036 ACT domain interface; other site 362663009037 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 362663009038 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362663009039 active site 362663009040 dimer interface [polypeptide binding]; other site 362663009041 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663009042 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 362663009043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663009044 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 362663009045 putative dimerization interface [polypeptide binding]; other site 362663009046 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 362663009047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663009048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663009049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663009050 Uncharacterized conserved protein [Function unknown]; Region: COG2968 362663009051 oxidative stress defense protein; Provisional; Region: PRK11087 362663009052 arginine exporter protein; Provisional; Region: PRK09304 362663009053 mechanosensitive channel MscS; Provisional; Region: PRK10334 362663009054 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663009055 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 362663009056 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 362663009057 active site 362663009058 intersubunit interface [polypeptide binding]; other site 362663009059 zinc binding site [ion binding]; other site 362663009060 Na+ binding site [ion binding]; other site 362663009061 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 362663009062 Phosphoglycerate kinase; Region: PGK; pfam00162 362663009063 substrate binding site [chemical binding]; other site 362663009064 hinge regions; other site 362663009065 ADP binding site [chemical binding]; other site 362663009066 catalytic site [active] 362663009067 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 362663009068 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 362663009069 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 362663009070 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 362663009071 trimer interface [polypeptide binding]; other site 362663009072 putative Zn binding site [ion binding]; other site 362663009073 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 362663009074 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 362663009075 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362663009076 Walker A/P-loop; other site 362663009077 ATP binding site [chemical binding]; other site 362663009078 Q-loop/lid; other site 362663009079 ABC transporter signature motif; other site 362663009080 Walker B; other site 362663009081 D-loop; other site 362663009082 H-loop/switch region; other site 362663009083 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 362663009084 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 362663009085 Walker A/P-loop; other site 362663009086 ATP binding site [chemical binding]; other site 362663009087 Q-loop/lid; other site 362663009088 ABC transporter signature motif; other site 362663009089 Walker B; other site 362663009090 D-loop; other site 362663009091 H-loop/switch region; other site 362663009092 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 362663009093 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 362663009094 active site 362663009095 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 362663009096 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 362663009097 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 362663009098 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663009099 putative NAD(P) binding site [chemical binding]; other site 362663009100 catalytic Zn binding site [ion binding]; other site 362663009101 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 362663009102 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 362663009103 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 362663009104 active site 362663009105 P-loop; other site 362663009106 phosphorylation site [posttranslational modification] 362663009107 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663009108 active site 362663009109 phosphorylation site [posttranslational modification] 362663009110 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 362663009111 SPFH domain / Band 7 family; Region: Band_7; pfam01145 362663009112 transketolase; Reviewed; Region: PRK12753 362663009113 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 362663009114 TPP-binding site [chemical binding]; other site 362663009115 dimer interface [polypeptide binding]; other site 362663009116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362663009117 PYR/PP interface [polypeptide binding]; other site 362663009118 dimer interface [polypeptide binding]; other site 362663009119 TPP binding site [chemical binding]; other site 362663009120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362663009121 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 362663009122 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 362663009123 agmatinase; Region: agmatinase; TIGR01230 362663009124 oligomer interface [polypeptide binding]; other site 362663009125 putative active site [active] 362663009126 Mn binding site [ion binding]; other site 362663009127 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 362663009128 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 362663009129 dimer interface [polypeptide binding]; other site 362663009130 active site 362663009131 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663009132 catalytic residues [active] 362663009133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 362663009134 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 362663009135 S-adenosylmethionine synthetase; Validated; Region: PRK05250 362663009136 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 362663009137 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 362663009138 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 362663009139 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 362663009140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009141 putative substrate translocation pore; other site 362663009142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009143 hypothetical protein; Provisional; Region: PRK04860 362663009144 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 362663009145 DNA-specific endonuclease I; Provisional; Region: PRK15137 362663009146 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 362663009147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 362663009148 RNA methyltransferase, RsmE family; Region: TIGR00046 362663009149 glutathione synthetase; Provisional; Region: PRK05246 362663009150 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 362663009151 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 362663009152 hypothetical protein; Validated; Region: PRK00228 362663009153 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 362663009154 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 362663009155 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 362663009156 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 362663009157 Walker A motif; other site 362663009158 ATP-binding site [chemical binding]; other site 362663009159 ATP binding site [chemical binding]; other site 362663009160 Walker B motif; other site 362663009161 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 362663009162 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663009163 catalytic residue [active] 362663009164 YGGT family; Region: YGGT; pfam02325 362663009165 YGGT family; Region: YGGT; pfam02325 362663009166 hypothetical protein; Validated; Region: PRK05090 362663009167 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 362663009168 active site 362663009169 dimerization interface [polypeptide binding]; other site 362663009170 HemN family oxidoreductase; Provisional; Region: PRK05660 362663009171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663009172 FeS/SAM binding site; other site 362663009173 HemN C-terminal domain; Region: HemN_C; pfam06969 362663009174 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 362663009175 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 362663009176 homodimer interface [polypeptide binding]; other site 362663009177 active site 362663009178 hypothetical protein; Provisional; Region: PRK10626 362663009179 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 362663009180 hypothetical protein; Provisional; Region: PRK11702 362663009181 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 362663009182 adenine DNA glycosylase; Provisional; Region: PRK10880 362663009183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 362663009184 minor groove reading motif; other site 362663009185 helix-hairpin-helix signature motif; other site 362663009186 substrate binding pocket [chemical binding]; other site 362663009187 active site 362663009188 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 362663009189 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 362663009190 DNA binding and oxoG recognition site [nucleotide binding] 362663009191 oxidative damage protection protein; Provisional; Region: PRK05408 362663009192 murein transglycosylase C; Provisional; Region: mltC; PRK11671 362663009193 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 362663009194 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663009195 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663009196 catalytic residue [active] 362663009197 nucleoside transporter; Region: 2A0110; TIGR00889 362663009198 ornithine decarboxylase; Provisional; Region: PRK13578 362663009199 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663009200 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663009201 homodimer interface [polypeptide binding]; other site 362663009202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009203 catalytic residue [active] 362663009204 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663009205 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 362663009206 integrase; Provisional; Region: PRK09692 362663009207 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663009208 active site 362663009209 Int/Topo IB signature motif; other site 362663009210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663009211 Transposase; Region: DDE_Tnp_ISL3; pfam01610 362663009212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663009213 Fimbrial protein; Region: Fimbrial; pfam00419 362663009214 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 362663009215 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663009216 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663009217 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 362663009218 PapC N-terminal domain; Region: PapC_N; pfam13954 362663009219 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663009220 PapC C-terminal domain; Region: PapC_C; pfam13953 362663009221 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663009222 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663009223 Integrase core domain; Region: rve; pfam00665 362663009224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 362663009225 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 362663009226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663009227 active site 362663009228 phosphorylation site [posttranslational modification] 362663009229 intermolecular recognition site; other site 362663009230 dimerization interface [polypeptide binding]; other site 362663009231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 362663009232 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663009233 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 362663009234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663009235 dimer interface [polypeptide binding]; other site 362663009236 phosphorylation site [posttranslational modification] 362663009237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663009238 ATP binding site [chemical binding]; other site 362663009239 G-X-G motif; other site 362663009240 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 362663009241 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 362663009242 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 362663009243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009245 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 362663009246 active site 362663009247 catalytic residues [active] 362663009248 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 362663009249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009250 putative substrate translocation pore; other site 362663009251 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663009252 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 362663009253 substrate binding site [chemical binding]; other site 362663009254 dimer interface [polypeptide binding]; other site 362663009255 ATP binding site [chemical binding]; other site 362663009256 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 362663009257 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 362663009258 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663009259 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 362663009260 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663009261 putative transposase OrfB; Reviewed; Region: PHA02517 362663009262 HTH-like domain; Region: HTH_21; pfam13276 362663009263 Integrase core domain; Region: rve; pfam00665 362663009264 Integrase core domain; Region: rve_3; pfam13683 362663009265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663009266 Transposase; Region: HTH_Tnp_1; pfam01527 362663009267 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663009268 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 362663009269 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 362663009270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663009271 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663009272 DNA-binding interface [nucleotide binding]; DNA binding site 362663009273 Integrase core domain; Region: rve; pfam00665 362663009274 transposase/IS protein; Provisional; Region: PRK09183 362663009275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663009276 Walker A motif; other site 362663009277 ATP binding site [chemical binding]; other site 362663009278 Walker B motif; other site 362663009279 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663009280 Haemolysin expression modulating protein; Region: HHA; pfam05321 362663009281 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 362663009282 Protein of unknown function (DUF342); Region: DUF342; pfam03961 362663009283 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 362663009284 Predicted GTPase [General function prediction only]; Region: COG3596 362663009285 YfjP GTPase; Region: YfjP; cd11383 362663009286 G1 box; other site 362663009287 GTP/Mg2+ binding site [chemical binding]; other site 362663009288 Switch I region; other site 362663009289 G2 box; other site 362663009290 Switch II region; other site 362663009291 G3 box; other site 362663009292 G4 box; other site 362663009293 G5 box; other site 362663009294 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 362663009295 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 362663009296 hypothetical protein; Provisional; Region: PRK09945 362663009297 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 362663009298 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 362663009299 Autotransporter beta-domain; Region: Autotransporter; smart00869 362663009300 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 362663009301 Domain of unknown function (DUF932); Region: DUF932; pfam06067 362663009302 Antirestriction protein; Region: Antirestrict; pfam03230 362663009303 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 362663009304 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663009305 MPN+ (JAMM) motif; other site 362663009306 Zinc-binding site [ion binding]; other site 362663009307 Protein of unknown function (DUF987); Region: DUF987; pfam06174 362663009308 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 362663009309 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 362663009310 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 362663009311 Methyltransferase domain; Region: Methyltransf_27; pfam13708 362663009312 KpsF/GutQ family protein; Region: kpsF; TIGR00393 362663009313 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 362663009314 putative active site [active] 362663009315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 362663009316 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 362663009317 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 362663009318 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 362663009319 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 362663009320 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 362663009321 Ligand binding site; other site 362663009322 oligomer interface; other site 362663009323 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 362663009324 Homeodomain-like domain; Region: HTH_23; pfam13384 362663009325 Winged helix-turn helix; Region: HTH_29; pfam13551 362663009326 Winged helix-turn helix; Region: HTH_33; pfam13592 362663009327 DDE superfamily endonuclease; Region: DDE_3; pfam13358 362663009328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 362663009329 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 362663009330 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 362663009331 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 362663009332 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 362663009333 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362663009334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362663009335 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 362663009336 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 362663009337 Walker A/P-loop; other site 362663009338 ATP binding site [chemical binding]; other site 362663009339 Q-loop/lid; other site 362663009340 ABC transporter signature motif; other site 362663009341 Walker B; other site 362663009342 D-loop; other site 362663009343 H-loop/switch region; other site 362663009344 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 362663009345 ABC-2 type transporter; Region: ABC2_membrane; cl17235 362663009346 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 362663009347 GspL-like protein; Provisional; Region: PRK09662 362663009348 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 362663009349 type II secretion system protein J; Region: gspJ; TIGR01711 362663009350 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 362663009351 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 362663009352 type II secretion system protein I; Region: gspI; TIGR01707 362663009353 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 362663009354 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 362663009355 Type II transport protein GspH; Region: GspH; pfam12019 362663009356 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 362663009357 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 362663009358 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 362663009359 type II secretion system protein F; Region: GspF; TIGR02120 362663009360 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663009361 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663009362 type II secretion system protein E; Region: type_II_gspE; TIGR02533 362663009363 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 362663009364 Walker A motif; other site 362663009365 ATP binding site [chemical binding]; other site 362663009366 Walker B motif; other site 362663009367 type II secretion system protein D; Region: type_II_gspD; TIGR02517 362663009368 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663009369 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663009370 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663009371 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 362663009372 putative type II secretion protein GspC; Provisional; Region: PRK09681 362663009373 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 362663009374 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663009375 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 362663009376 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 362663009377 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 362663009378 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 362663009379 Peptidase M60-like family; Region: M60-like; pfam13402 362663009380 glycolate transporter; Provisional; Region: PRK09695 362663009381 L-lactate permease; Region: Lactate_perm; cl00701 362663009382 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 362663009383 active site 362663009384 hypothetical protein; Provisional; Region: PRK09732 362663009385 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 362663009386 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663009387 Cysteine-rich domain; Region: CCG; pfam02754 362663009388 Cysteine-rich domain; Region: CCG; pfam02754 362663009389 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 362663009390 FAD binding domain; Region: FAD_binding_4; pfam01565 362663009391 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 362663009392 FAD binding domain; Region: FAD_binding_4; pfam01565 362663009393 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 362663009394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663009395 DNA-binding site [nucleotide binding]; DNA binding site 362663009396 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663009397 acyl-CoA synthetase; Validated; Region: PRK09192 362663009398 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 362663009399 acyl-activating enzyme (AAE) consensus motif; other site 362663009400 active site 362663009401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 362663009402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 362663009403 NAD(P) binding site [chemical binding]; other site 362663009404 active site 362663009405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 362663009406 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 362663009407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 362663009408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663009409 catalytic residue [active] 362663009410 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 362663009411 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 362663009412 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 362663009413 Predicted permeases [General function prediction only]; Region: COG0795 362663009414 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 362663009415 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 362663009416 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 362663009417 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 362663009418 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 362663009419 active site 362663009420 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 362663009421 TMP-binding site; other site 362663009422 ATP-binding site [chemical binding]; other site 362663009423 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 362663009424 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 362663009425 TMP-binding site; other site 362663009426 ATP-binding site [chemical binding]; other site 362663009427 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 362663009428 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 362663009429 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 362663009430 CHAP domain; Region: CHAP; pfam05257 362663009431 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 362663009432 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 362663009433 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 362663009434 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 362663009435 dimer interface [polypeptide binding]; other site 362663009436 N-terminal domain interface [polypeptide binding]; other site 362663009437 active site 362663009438 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 362663009439 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 362663009440 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 362663009441 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 362663009442 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 362663009443 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 362663009444 putative substrate-binding site; other site 362663009445 nickel binding site [ion binding]; other site 362663009446 hydrogenase 2 large subunit; Provisional; Region: PRK10467 362663009447 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 362663009448 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 362663009449 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 362663009450 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 362663009451 4Fe-4S binding domain; Region: Fer4_6; pfam12837 362663009452 hydrogenase 2 small subunit; Provisional; Region: PRK10468 362663009453 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 362663009454 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 362663009455 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 362663009456 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 362663009457 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 362663009458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663009459 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663009460 active site 362663009461 catalytic tetrad [active] 362663009462 hypothetical protein; Provisional; Region: PRK05208 362663009463 oxidoreductase; Provisional; Region: PRK07985 362663009464 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 362663009465 NAD binding site [chemical binding]; other site 362663009466 metal binding site [ion binding]; metal-binding site 362663009467 active site 362663009468 biopolymer transport protein ExbD; Provisional; Region: PRK11267 362663009469 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 362663009470 biopolymer transport protein ExbB; Provisional; Region: PRK10414 362663009471 cystathionine beta-lyase; Provisional; Region: PRK08114 362663009472 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 362663009473 homodimer interface [polypeptide binding]; other site 362663009474 substrate-cofactor binding pocket; other site 362663009475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009476 catalytic residue [active] 362663009477 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362663009478 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 362663009479 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 362663009480 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 362663009481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663009482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663009483 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 362663009484 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 362663009485 dimer interface [polypeptide binding]; other site 362663009486 active site 362663009487 metal binding site [ion binding]; metal-binding site 362663009488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 362663009489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 362663009490 active site 362663009491 catalytic tetrad [active] 362663009492 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 362663009493 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 362663009494 putative outer membrane lipoprotein; Provisional; Region: PRK09973 362663009495 hypothetical protein; Provisional; Region: PRK01254 362663009496 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 362663009497 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 362663009498 Transcriptional regulators [Transcription]; Region: FadR; COG2186 362663009499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663009500 DNA-binding site [nucleotide binding]; DNA binding site 362663009501 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663009502 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 362663009503 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663009504 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663009505 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663009506 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 362663009507 putative NAD(P) binding site [chemical binding]; other site 362663009508 catalytic Zn binding site [ion binding]; other site 362663009509 structural Zn binding site [ion binding]; other site 362663009510 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 362663009511 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 362663009512 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 362663009513 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 362663009514 DctM-like transporters; Region: DctM; pfam06808 362663009515 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 362663009516 FtsI repressor; Provisional; Region: PRK10883 362663009517 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 362663009518 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 362663009519 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 362663009520 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 362663009521 putative acyl-acceptor binding pocket; other site 362663009522 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 362663009523 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 362663009524 CAP-like domain; other site 362663009525 active site 362663009526 primary dimer interface [polypeptide binding]; other site 362663009527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 362663009528 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 362663009529 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 362663009530 peptide binding site [polypeptide binding]; other site 362663009531 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 362663009532 TIGR00156 family protein; Region: TIGR00156 362663009533 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 362663009534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663009535 active site 362663009536 phosphorylation site [posttranslational modification] 362663009537 intermolecular recognition site; other site 362663009538 dimerization interface [polypeptide binding]; other site 362663009539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663009540 DNA binding site [nucleotide binding] 362663009541 sensor protein QseC; Provisional; Region: PRK10337 362663009542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663009543 dimer interface [polypeptide binding]; other site 362663009544 phosphorylation site [posttranslational modification] 362663009545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663009546 ATP binding site [chemical binding]; other site 362663009547 Mg2+ binding site [ion binding]; other site 362663009548 G-X-G motif; other site 362663009549 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 362663009550 Uncharacterized conserved protein [Function unknown]; Region: COG1359 362663009551 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 362663009552 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362663009553 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 362663009554 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 362663009555 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 362663009556 siderophore binding site; other site 362663009557 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 362663009558 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663009559 ABC-ATPase subunit interface; other site 362663009560 dimer interface [polypeptide binding]; other site 362663009561 putative PBP binding regions; other site 362663009562 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663009563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663009564 dimer interface [polypeptide binding]; other site 362663009565 putative PBP binding regions; other site 362663009566 ABC-ATPase subunit interface; other site 362663009567 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 362663009568 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663009569 Walker A/P-loop; other site 362663009570 ATP binding site [chemical binding]; other site 362663009571 Q-loop/lid; other site 362663009572 ABC transporter signature motif; other site 362663009573 Walker B; other site 362663009574 D-loop; other site 362663009575 H-loop/switch region; other site 362663009576 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 362663009577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663009578 N-terminal plug; other site 362663009579 ligand-binding site [chemical binding]; other site 362663009580 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 362663009581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663009582 ATP binding site [chemical binding]; other site 362663009583 Mg2+ binding site [ion binding]; other site 362663009584 G-X-G motif; other site 362663009585 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 362663009586 anchoring element; other site 362663009587 dimer interface [polypeptide binding]; other site 362663009588 ATP binding site [chemical binding]; other site 362663009589 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 362663009590 active site 362663009591 metal binding site [ion binding]; metal-binding site 362663009592 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 362663009593 esterase YqiA; Provisional; Region: PRK11071 362663009594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 362663009595 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 362663009596 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 362663009597 active site 362663009598 metal binding site [ion binding]; metal-binding site 362663009599 hexamer interface [polypeptide binding]; other site 362663009600 putative dehydrogenase; Provisional; Region: PRK11039 362663009601 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 362663009602 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 362663009603 dimer interface [polypeptide binding]; other site 362663009604 ADP-ribose binding site [chemical binding]; other site 362663009605 active site 362663009606 nudix motif; other site 362663009607 metal binding site [ion binding]; metal-binding site 362663009608 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 362663009609 hypothetical protein; Provisional; Region: PRK11653 362663009610 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 362663009611 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 362663009612 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 362663009613 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 362663009614 catalytic residues [active] 362663009615 hinge region; other site 362663009616 alpha helical domain; other site 362663009617 putative disulfide oxidoreductase; Provisional; Region: PRK04307 362663009618 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 362663009619 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 362663009620 putative active site [active] 362663009621 metal binding site [ion binding]; metal-binding site 362663009622 zinc transporter ZupT; Provisional; Region: PRK04201 362663009623 ZIP Zinc transporter; Region: Zip; pfam02535 362663009624 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 362663009625 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 362663009626 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 362663009627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 362663009628 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 362663009629 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 362663009630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 362663009631 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 362663009632 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 362663009633 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 362663009634 putative ribose interaction site [chemical binding]; other site 362663009635 putative ADP binding site [chemical binding]; other site 362663009636 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 362663009637 active site 362663009638 nucleotide binding site [chemical binding]; other site 362663009639 HIGH motif; other site 362663009640 KMSKS motif; other site 362663009641 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 362663009642 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 362663009643 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 362663009644 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 362663009645 metal binding triad; other site 362663009646 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 362663009647 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 362663009648 metal binding triad; other site 362663009649 Uncharacterized conserved protein [Function unknown]; Region: COG3025 362663009650 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 362663009651 putative active site [active] 362663009652 putative metal binding residues [ion binding]; other site 362663009653 signature motif; other site 362663009654 putative triphosphate binding site [ion binding]; other site 362663009655 CHAD domain; Region: CHAD; pfam05235 362663009656 SH3 domain-containing protein; Provisional; Region: PRK10884 362663009657 Bacterial SH3 domain homologues; Region: SH3b; smart00287 362663009658 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 362663009659 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 362663009660 active site 362663009661 NTP binding site [chemical binding]; other site 362663009662 metal binding triad [ion binding]; metal-binding site 362663009663 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 362663009664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362663009665 Zn2+ binding site [ion binding]; other site 362663009666 Mg2+ binding site [ion binding]; other site 362663009667 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 362663009668 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 362663009669 homooctamer interface [polypeptide binding]; other site 362663009670 active site 362663009671 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 362663009672 transcriptional activator TtdR; Provisional; Region: PRK09801 362663009673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663009674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 362663009675 putative effector binding pocket; other site 362663009676 putative dimerization interface [polypeptide binding]; other site 362663009677 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 362663009678 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 362663009679 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663009680 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 362663009681 transmembrane helices; other site 362663009682 UGMP family protein; Validated; Region: PRK09604 362663009683 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 362663009684 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 362663009685 DNA primase; Validated; Region: dnaG; PRK05667 362663009686 CHC2 zinc finger; Region: zf-CHC2; pfam01807 362663009687 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 362663009688 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 362663009689 active site 362663009690 metal binding site [ion binding]; metal-binding site 362663009691 interdomain interaction site; other site 362663009692 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 362663009693 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 362663009694 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 362663009695 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 362663009696 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 362663009697 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 362663009698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362663009699 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 362663009700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362663009701 DNA binding residues [nucleotide binding] 362663009702 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 362663009703 active site 362663009704 SUMO-1 interface [polypeptide binding]; other site 362663009705 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 362663009706 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 362663009707 FAD binding pocket [chemical binding]; other site 362663009708 FAD binding motif [chemical binding]; other site 362663009709 phosphate binding motif [ion binding]; other site 362663009710 NAD binding pocket [chemical binding]; other site 362663009711 Predicted transcriptional regulators [Transcription]; Region: COG1695 362663009712 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 362663009713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663009714 PAS fold; Region: PAS_3; pfam08447 362663009715 putative active site [active] 362663009716 heme pocket [chemical binding]; other site 362663009717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 362663009718 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 362663009719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 362663009720 dimer interface [polypeptide binding]; other site 362663009721 putative CheW interface [polypeptide binding]; other site 362663009722 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 362663009723 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663009724 inhibitor-cofactor binding pocket; inhibition site 362663009725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009726 catalytic residue [active] 362663009727 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 362663009728 dimer interface [polypeptide binding]; other site 362663009729 putative tRNA-binding site [nucleotide binding]; other site 362663009730 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 362663009731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663009732 DNA binding site [nucleotide binding] 362663009733 domain linker motif; other site 362663009734 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 362663009735 putative dimerization interface [polypeptide binding]; other site 362663009736 putative ligand binding site [chemical binding]; other site 362663009737 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 362663009738 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 362663009739 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 362663009740 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 362663009741 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 362663009742 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 362663009743 inner membrane transporter YjeM; Provisional; Region: PRK15238 362663009744 alpha-glucosidase; Provisional; Region: PRK10137 362663009745 Protein of unknown function, DUF608; Region: DUF608; pfam04685 362663009746 Trehalase; Region: Trehalase; cl17346 362663009747 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 362663009748 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 362663009749 active site 362663009750 FMN binding site [chemical binding]; other site 362663009751 2,4-decadienoyl-CoA binding site; other site 362663009752 catalytic residue [active] 362663009753 4Fe-4S cluster binding site [ion binding]; other site 362663009754 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 362663009755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663009756 non-specific DNA binding site [nucleotide binding]; other site 362663009757 salt bridge; other site 362663009758 sequence-specific DNA binding site [nucleotide binding]; other site 362663009759 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 362663009760 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 362663009761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663009762 S-adenosylmethionine binding site [chemical binding]; other site 362663009763 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 362663009764 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 362663009765 putative active site [active] 362663009766 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 362663009767 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663009768 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 362663009769 serine/threonine transporter SstT; Provisional; Region: PRK13628 362663009770 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 362663009771 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 362663009772 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 362663009773 galactarate dehydratase; Region: galactar-dH20; TIGR03248 362663009774 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 362663009775 Glucuronate isomerase; Region: UxaC; pfam02614 362663009776 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 362663009777 D-galactonate transporter; Region: 2A0114; TIGR00893 362663009778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009779 putative substrate translocation pore; other site 362663009780 CblD like pilus biogenesis initiator; Region: CblD; cl06460 362663009781 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 362663009782 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663009783 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 362663009784 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 362663009785 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 362663009786 putative fimbrial protein TcfA; Provisional; Region: PRK15308 362663009787 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 362663009788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663009789 DNA-binding site [nucleotide binding]; DNA binding site 362663009790 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663009791 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 362663009792 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 362663009793 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 362663009794 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 362663009795 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 362663009796 Predicted membrane protein [Function unknown]; Region: COG5393 362663009797 YqjK-like protein; Region: YqjK; pfam13997 362663009798 Predicted membrane protein [Function unknown]; Region: COG2259 362663009799 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 362663009800 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 362663009801 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 362663009802 putative dimer interface [polypeptide binding]; other site 362663009803 N-terminal domain interface [polypeptide binding]; other site 362663009804 putative substrate binding pocket (H-site) [chemical binding]; other site 362663009805 Predicted membrane protein [Function unknown]; Region: COG3152 362663009806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663009807 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 362663009808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663009809 dimerization interface [polypeptide binding]; other site 362663009810 Pirin-related protein [General function prediction only]; Region: COG1741 362663009811 Pirin; Region: Pirin; pfam02678 362663009812 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 362663009813 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 362663009814 serine transporter; Region: stp; TIGR00814 362663009815 L-serine dehydratase TdcG; Provisional; Region: PRK15040 362663009816 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 362663009817 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 362663009818 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 362663009819 homotrimer interaction site [polypeptide binding]; other site 362663009820 putative active site [active] 362663009821 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 362663009822 Pyruvate formate lyase 1; Region: PFL1; cd01678 362663009823 coenzyme A binding site [chemical binding]; other site 362663009824 active site 362663009825 catalytic residues [active] 362663009826 glycine loop; other site 362663009827 propionate/acetate kinase; Provisional; Region: PRK12379 362663009828 Acetokinase family; Region: Acetate_kinase; cl17229 362663009829 threonine/serine transporter TdcC; Provisional; Region: PRK13629 362663009830 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 362663009831 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 362663009832 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 362663009833 tetramer interface [polypeptide binding]; other site 362663009834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663009835 catalytic residue [active] 362663009836 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 362663009837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663009838 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 362663009839 putative substrate binding pocket [chemical binding]; other site 362663009840 putative dimerization interface [polypeptide binding]; other site 362663009841 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 362663009842 glycerate kinase I; Provisional; Region: PRK10342 362663009843 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 362663009844 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 362663009845 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 362663009846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663009847 D-galactonate transporter; Region: 2A0114; TIGR00893 362663009848 putative substrate translocation pore; other site 362663009849 galactarate dehydratase; Region: galactar-dH20; TIGR03248 362663009850 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 362663009851 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 362663009852 putative regulator PrlF; Provisional; Region: PRK09974 362663009853 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 362663009854 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 362663009855 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 362663009856 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 362663009857 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663009858 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 362663009859 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362663009860 active site 362663009861 phosphorylation site [posttranslational modification] 362663009862 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 362663009863 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 362663009864 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362663009865 active pocket/dimerization site; other site 362663009866 active site 362663009867 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 362663009868 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 362663009869 active site 362663009870 dimer interface [polypeptide binding]; other site 362663009871 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 362663009872 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 362663009873 dimer interface [polypeptide binding]; other site 362663009874 active site 362663009875 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 362663009876 putative active site [active] 362663009877 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 362663009878 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 362663009879 active site 362663009880 intersubunit interface [polypeptide binding]; other site 362663009881 zinc binding site [ion binding]; other site 362663009882 Na+ binding site [ion binding]; other site 362663009883 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362663009884 active site 362663009885 phosphorylation site [posttranslational modification] 362663009886 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 362663009887 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 362663009888 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 362663009889 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 362663009890 active site 362663009891 trimer interface [polypeptide binding]; other site 362663009892 allosteric site; other site 362663009893 active site lid [active] 362663009894 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 362663009895 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 362663009896 putative SAM binding site [chemical binding]; other site 362663009897 putative homodimer interface [polypeptide binding]; other site 362663009898 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 362663009899 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 362663009900 putative ligand binding site [chemical binding]; other site 362663009901 TIGR00252 family protein; Region: TIGR00252 362663009902 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 362663009903 dimer interface [polypeptide binding]; other site 362663009904 active site 362663009905 outer membrane lipoprotein; Provisional; Region: PRK11023 362663009906 BON domain; Region: BON; pfam04972 362663009907 BON domain; Region: BON; pfam04972 362663009908 Predicted permease; Region: DUF318; pfam03773 362663009909 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 362663009910 NADH(P)-binding; Region: NAD_binding_10; pfam13460 362663009911 NAD binding site [chemical binding]; other site 362663009912 active site 362663009913 intracellular protease, PfpI family; Region: PfpI; TIGR01382 362663009914 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 362663009915 proposed catalytic triad [active] 362663009916 conserved cys residue [active] 362663009917 hypothetical protein; Provisional; Region: PRK03467 362663009918 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 362663009919 GIY-YIG motif/motif A; other site 362663009920 putative active site [active] 362663009921 putative metal binding site [ion binding]; other site 362663009922 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 362663009923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663009924 Coenzyme A binding pocket [chemical binding]; other site 362663009925 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 362663009926 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 362663009927 Peptidase family U32; Region: Peptidase_U32; pfam01136 362663009928 putative protease; Provisional; Region: PRK15447 362663009929 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 362663009930 hypothetical protein; Provisional; Region: PRK10508 362663009931 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 362663009932 tryptophan permease; Provisional; Region: PRK10483 362663009933 aromatic amino acid transport protein; Region: araaP; TIGR00837 362663009934 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 362663009935 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362663009936 ATP binding site [chemical binding]; other site 362663009937 Mg++ binding site [ion binding]; other site 362663009938 motif III; other site 362663009939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663009940 nucleotide binding region [chemical binding]; other site 362663009941 ATP-binding site [chemical binding]; other site 362663009942 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 362663009943 putative RNA binding site [nucleotide binding]; other site 362663009944 lipoprotein NlpI; Provisional; Region: PRK11189 362663009945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663009946 binding surface 362663009947 TPR motif; other site 362663009948 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 362663009949 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 362663009950 RNase E interface [polypeptide binding]; other site 362663009951 trimer interface [polypeptide binding]; other site 362663009952 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 362663009953 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 362663009954 RNase E interface [polypeptide binding]; other site 362663009955 trimer interface [polypeptide binding]; other site 362663009956 active site 362663009957 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 362663009958 putative nucleic acid binding region [nucleotide binding]; other site 362663009959 G-X-X-G motif; other site 362663009960 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 362663009961 RNA binding site [nucleotide binding]; other site 362663009962 domain interface; other site 362663009963 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 362663009964 16S/18S rRNA binding site [nucleotide binding]; other site 362663009965 S13e-L30e interaction site [polypeptide binding]; other site 362663009966 25S rRNA binding site [nucleotide binding]; other site 362663009967 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 362663009968 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 362663009969 RNA binding site [nucleotide binding]; other site 362663009970 active site 362663009971 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 362663009972 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 362663009973 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 362663009974 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 362663009975 translation initiation factor IF-2; Region: IF-2; TIGR00487 362663009976 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 362663009977 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 362663009978 G1 box; other site 362663009979 putative GEF interaction site [polypeptide binding]; other site 362663009980 GTP/Mg2+ binding site [chemical binding]; other site 362663009981 Switch I region; other site 362663009982 G2 box; other site 362663009983 G3 box; other site 362663009984 Switch II region; other site 362663009985 G4 box; other site 362663009986 G5 box; other site 362663009987 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 362663009988 Translation-initiation factor 2; Region: IF-2; pfam11987 362663009989 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 362663009990 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 362663009991 NusA N-terminal domain; Region: NusA_N; pfam08529 362663009992 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 362663009993 RNA binding site [nucleotide binding]; other site 362663009994 homodimer interface [polypeptide binding]; other site 362663009995 NusA-like KH domain; Region: KH_5; pfam13184 362663009996 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 362663009997 G-X-X-G motif; other site 362663009998 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 362663009999 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 362663010000 ribosome maturation protein RimP; Reviewed; Region: PRK00092 362663010001 Sm and related proteins; Region: Sm_like; cl00259 362663010002 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 362663010003 putative oligomer interface [polypeptide binding]; other site 362663010004 putative RNA binding site [nucleotide binding]; other site 362663010005 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 362663010006 ANP binding site [chemical binding]; other site 362663010007 Substrate Binding Site II [chemical binding]; other site 362663010008 Substrate Binding Site I [chemical binding]; other site 362663010009 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 362663010010 Sulfatase; Region: Sulfatase; cl17466 362663010011 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 362663010012 Preprotein translocase SecG subunit; Region: SecG; pfam03840 362663010013 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 362663010014 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 362663010015 active site 362663010016 substrate binding site [chemical binding]; other site 362663010017 metal binding site [ion binding]; metal-binding site 362663010018 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 362663010019 dihydropteroate synthase; Region: DHPS; TIGR01496 362663010020 substrate binding pocket [chemical binding]; other site 362663010021 dimer interface [polypeptide binding]; other site 362663010022 inhibitor binding site; inhibition site 362663010023 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 362663010024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663010025 Walker A motif; other site 362663010026 ATP binding site [chemical binding]; other site 362663010027 Walker B motif; other site 362663010028 arginine finger; other site 362663010029 Peptidase family M41; Region: Peptidase_M41; pfam01434 362663010030 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 362663010031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663010032 S-adenosylmethionine binding site [chemical binding]; other site 362663010033 RNA-binding protein YhbY; Provisional; Region: PRK10343 362663010034 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 362663010035 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 362663010036 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 362663010037 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 362663010038 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 362663010039 GTPase CgtA; Reviewed; Region: obgE; PRK12298 362663010040 GTP1/OBG; Region: GTP1_OBG; pfam01018 362663010041 Obg GTPase; Region: Obg; cd01898 362663010042 G1 box; other site 362663010043 GTP/Mg2+ binding site [chemical binding]; other site 362663010044 Switch I region; other site 362663010045 G2 box; other site 362663010046 G3 box; other site 362663010047 Switch II region; other site 362663010048 G4 box; other site 362663010049 G5 box; other site 362663010050 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 362663010051 EamA-like transporter family; Region: EamA; pfam00892 362663010052 EamA-like transporter family; Region: EamA; cl17759 362663010053 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 362663010054 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 362663010055 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 362663010056 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 362663010057 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 362663010058 substrate binding pocket [chemical binding]; other site 362663010059 chain length determination region; other site 362663010060 substrate-Mg2+ binding site; other site 362663010061 catalytic residues [active] 362663010062 aspartate-rich region 1; other site 362663010063 active site lid residues [active] 362663010064 aspartate-rich region 2; other site 362663010065 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 362663010066 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 362663010067 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 362663010068 hinge; other site 362663010069 active site 362663010070 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 362663010071 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 362663010072 anti sigma factor interaction site; other site 362663010073 regulatory phosphorylation site [posttranslational modification]; other site 362663010074 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 362663010075 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 362663010076 mce related protein; Region: MCE; pfam02470 362663010077 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 362663010078 conserved hypothetical integral membrane protein; Region: TIGR00056 362663010079 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 362663010080 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 362663010081 Walker A/P-loop; other site 362663010082 ATP binding site [chemical binding]; other site 362663010083 Q-loop/lid; other site 362663010084 ABC transporter signature motif; other site 362663010085 Walker B; other site 362663010086 D-loop; other site 362663010087 H-loop/switch region; other site 362663010088 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 362663010089 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 362663010090 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 362663010091 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 362663010092 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 362663010093 putative active site [active] 362663010094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 362663010095 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 362663010096 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 362663010097 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 362663010098 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 362663010099 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 362663010100 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 362663010101 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 362663010102 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 362663010103 Walker A/P-loop; other site 362663010104 ATP binding site [chemical binding]; other site 362663010105 Q-loop/lid; other site 362663010106 ABC transporter signature motif; other site 362663010107 Walker B; other site 362663010108 D-loop; other site 362663010109 H-loop/switch region; other site 362663010110 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 362663010111 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 362663010112 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 362663010113 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 362663010114 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 362663010115 30S subunit binding site; other site 362663010116 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663010117 active site 362663010118 phosphorylation site [posttranslational modification] 362663010119 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 362663010120 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663010121 dimerization domain swap beta strand [polypeptide binding]; other site 362663010122 regulatory protein interface [polypeptide binding]; other site 362663010123 active site 362663010124 regulatory phosphorylation site [posttranslational modification]; other site 362663010125 hypothetical protein; Provisional; Region: PRK10345 362663010126 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 362663010127 Transglycosylase; Region: Transgly; cl17702 362663010128 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 362663010129 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 362663010130 conserved cys residue [active] 362663010131 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 362663010132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663010133 putative active site [active] 362663010134 heme pocket [chemical binding]; other site 362663010135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663010136 dimer interface [polypeptide binding]; other site 362663010137 phosphorylation site [posttranslational modification] 362663010138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663010139 ATP binding site [chemical binding]; other site 362663010140 Mg2+ binding site [ion binding]; other site 362663010141 G-X-G motif; other site 362663010142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663010143 active site 362663010144 phosphorylation site [posttranslational modification] 362663010145 intermolecular recognition site; other site 362663010146 dimerization interface [polypeptide binding]; other site 362663010147 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 362663010148 putative binding surface; other site 362663010149 active site 362663010150 radical SAM protein, TIGR01212 family; Region: TIGR01212 362663010151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663010152 FeS/SAM binding site; other site 362663010153 glutamate synthase [NADPH] large chain precursor nonfunction due to the fram shift 362663010154 glutamate synthase [NADPH] large chain precursor nonfunction due to the fram shift 362663010155 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 362663010156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663010157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663010158 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 362663010159 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 362663010160 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 362663010161 N-acetylmannosamine kinase; Provisional; Region: PRK05082 362663010162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663010163 nucleotide binding site [chemical binding]; other site 362663010164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 362663010165 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 362663010166 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 362663010167 putative active site cavity [active] 362663010168 putative sialic acid transporter; Provisional; Region: PRK03893 362663010169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663010170 putative substrate translocation pore; other site 362663010171 N-acetylneuraminate lyase; Region: nanA; TIGR00683 362663010172 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 362663010173 inhibitor site; inhibition site 362663010174 active site 362663010175 dimer interface [polypeptide binding]; other site 362663010176 catalytic residue [active] 362663010177 transcriptional regulator NanR; Provisional; Region: PRK03837 362663010178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663010179 DNA-binding site [nucleotide binding]; DNA binding site 362663010180 FCD domain; Region: FCD; pfam07729 362663010181 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 362663010182 stringent starvation protein A; Provisional; Region: sspA; PRK09481 362663010183 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 362663010184 C-terminal domain interface [polypeptide binding]; other site 362663010185 putative GSH binding site (G-site) [chemical binding]; other site 362663010186 dimer interface [polypeptide binding]; other site 362663010187 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 362663010188 dimer interface [polypeptide binding]; other site 362663010189 N-terminal domain interface [polypeptide binding]; other site 362663010190 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 362663010191 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 362663010192 23S rRNA interface [nucleotide binding]; other site 362663010193 L3 interface [polypeptide binding]; other site 362663010194 Predicted ATPase [General function prediction only]; Region: COG1485 362663010195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 362663010196 hypothetical protein; Provisional; Region: PRK11677 362663010197 serine endoprotease; Provisional; Region: PRK10139 362663010198 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 362663010199 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663010200 protein binding site [polypeptide binding]; other site 362663010201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663010202 serine endoprotease; Provisional; Region: PRK10898 362663010203 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 362663010204 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 362663010205 malate dehydrogenase; Provisional; Region: PRK05086 362663010206 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 362663010207 NAD binding site [chemical binding]; other site 362663010208 dimerization interface [polypeptide binding]; other site 362663010209 Substrate binding site [chemical binding]; other site 362663010210 arginine repressor; Provisional; Region: PRK05066 362663010211 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 362663010212 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 362663010213 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663010214 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 362663010215 RNAase interaction site [polypeptide binding]; other site 362663010216 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 362663010217 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663010218 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 362663010219 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663010220 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663010221 efflux system membrane protein; Provisional; Region: PRK11594 362663010222 transcriptional regulator; Provisional; Region: PRK10632 362663010223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663010224 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 362663010225 putative effector binding pocket; other site 362663010226 dimerization interface [polypeptide binding]; other site 362663010227 protease TldD; Provisional; Region: tldD; PRK10735 362663010228 hypothetical protein; Provisional; Region: PRK10899 362663010229 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 362663010230 ribonuclease G; Provisional; Region: PRK11712 362663010231 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 362663010232 homodimer interface [polypeptide binding]; other site 362663010233 oligonucleotide binding site [chemical binding]; other site 362663010234 Maf-like protein; Region: Maf; pfam02545 362663010235 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 362663010236 active site 362663010237 dimer interface [polypeptide binding]; other site 362663010238 rod shape-determining protein MreD; Provisional; Region: PRK11060 362663010239 rod shape-determining protein MreC; Region: mreC; TIGR00219 362663010240 rod shape-determining protein MreC; Region: MreC; pfam04085 362663010241 rod shape-determining protein MreB; Provisional; Region: PRK13927 362663010242 MreB and similar proteins; Region: MreB_like; cd10225 362663010243 nucleotide binding site [chemical binding]; other site 362663010244 Mg binding site [ion binding]; other site 362663010245 putative protofilament interaction site [polypeptide binding]; other site 362663010246 RodZ interaction site [polypeptide binding]; other site 362663010247 regulatory protein CsrD; Provisional; Region: PRK11059 362663010248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663010249 metal binding site [ion binding]; metal-binding site 362663010250 active site 362663010251 I-site; other site 362663010252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663010253 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 362663010254 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 362663010255 NADP binding site [chemical binding]; other site 362663010256 dimer interface [polypeptide binding]; other site 362663010257 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 362663010258 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 362663010259 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 362663010260 carboxyltransferase (CT) interaction site; other site 362663010261 biotinylation site [posttranslational modification]; other site 362663010262 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 362663010263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 362663010264 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 362663010265 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 362663010266 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 362663010267 active site 362663010268 catalytic residues [active] 362663010269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663010270 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 362663010271 substrate binding site [chemical binding]; other site 362663010272 ATP binding site [chemical binding]; other site 362663010273 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663010274 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663010275 TM-ABC transporter signature motif; other site 362663010276 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 362663010277 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663010278 Walker A/P-loop; other site 362663010279 ATP binding site [chemical binding]; other site 362663010280 Q-loop/lid; other site 362663010281 ABC transporter signature motif; other site 362663010282 Walker B; other site 362663010283 D-loop; other site 362663010284 H-loop/switch region; other site 362663010285 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663010286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 362663010287 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 362663010288 putative ligand binding site [chemical binding]; other site 362663010289 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362663010290 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 362663010291 intersubunit interface [polypeptide binding]; other site 362663010292 active site 362663010293 zinc binding site [ion binding]; other site 362663010294 Na+ binding site [ion binding]; other site 362663010295 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663010296 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 362663010297 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663010298 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663010299 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 362663010300 substrate binding site [chemical binding]; other site 362663010301 ATP binding site [chemical binding]; other site 362663010302 hypothetical protein; Provisional; Region: PRK10633 362663010303 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 362663010304 Na binding site [ion binding]; other site 362663010305 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 362663010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 362663010307 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 362663010308 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 362663010309 FMN binding site [chemical binding]; other site 362663010310 active site 362663010311 catalytic residues [active] 362663010312 substrate binding site [chemical binding]; other site 362663010313 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 362663010314 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 362663010315 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 362663010316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663010317 DNA methylase; Region: N6_N4_Mtase; pfam01555 362663010318 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 362663010319 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 362663010320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663010321 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 362663010322 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 362663010323 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663010324 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663010325 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 362663010326 Protein export membrane protein; Region: SecD_SecF; cl14618 362663010327 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 362663010328 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 362663010329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663010330 substrate binding pocket [chemical binding]; other site 362663010331 membrane-bound complex binding site; other site 362663010332 hinge residues; other site 362663010333 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 362663010334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663010335 conserved gate region; other site 362663010336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663010337 dimer interface [polypeptide binding]; other site 362663010338 conserved gate region; other site 362663010339 putative PBP binding loops; other site 362663010340 ABC-ATPase subunit interface; other site 362663010341 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 362663010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663010343 dimer interface [polypeptide binding]; other site 362663010344 conserved gate region; other site 362663010345 putative PBP binding loops; other site 362663010346 ABC-ATPase subunit interface; other site 362663010347 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 362663010348 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 362663010349 Walker A/P-loop; other site 362663010350 ATP binding site [chemical binding]; other site 362663010351 Q-loop/lid; other site 362663010352 ABC transporter signature motif; other site 362663010353 Walker B; other site 362663010354 D-loop; other site 362663010355 H-loop/switch region; other site 362663010356 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 362663010357 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 362663010358 trimer interface [polypeptide binding]; other site 362663010359 putative metal binding site [ion binding]; other site 362663010360 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 362663010361 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 362663010362 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 362663010363 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 362663010364 shikimate binding site; other site 362663010365 NAD(P) binding site [chemical binding]; other site 362663010366 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 362663010367 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362663010368 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 362663010369 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362663010370 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 362663010371 hypothetical protein; Validated; Region: PRK03430 362663010372 hypothetical protein; Provisional; Region: PRK10736 362663010373 DNA protecting protein DprA; Region: dprA; TIGR00732 362663010374 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 362663010375 active site 362663010376 catalytic residues [active] 362663010377 metal binding site [ion binding]; metal-binding site 362663010378 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 362663010379 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 362663010380 putative active site [active] 362663010381 substrate binding site [chemical binding]; other site 362663010382 putative cosubstrate binding site; other site 362663010383 catalytic site [active] 362663010384 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 362663010385 substrate binding site [chemical binding]; other site 362663010386 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 362663010387 putative RNA binding site [nucleotide binding]; other site 362663010388 16S rRNA methyltransferase B; Provisional; Region: PRK10901 362663010389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663010390 S-adenosylmethionine binding site [chemical binding]; other site 362663010391 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 362663010392 TrkA-N domain; Region: TrkA_N; pfam02254 362663010393 TrkA-C domain; Region: TrkA_C; pfam02080 362663010394 TrkA-N domain; Region: TrkA_N; pfam02254 362663010395 TrkA-C domain; Region: TrkA_C; pfam02080 362663010396 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 362663010397 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 362663010398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 362663010399 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 362663010400 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 362663010401 DNA binding residues [nucleotide binding] 362663010402 dimer interface [polypeptide binding]; other site 362663010403 metal binding site [ion binding]; metal-binding site 362663010404 hypothetical protein; Provisional; Region: PRK10203 362663010405 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 362663010406 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 362663010407 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 362663010408 alphaNTD homodimer interface [polypeptide binding]; other site 362663010409 alphaNTD - beta interaction site [polypeptide binding]; other site 362663010410 alphaNTD - beta' interaction site [polypeptide binding]; other site 362663010411 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 362663010412 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 362663010413 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 362663010414 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663010415 RNA binding surface [nucleotide binding]; other site 362663010416 30S ribosomal protein S11; Validated; Region: PRK05309 362663010417 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 362663010418 30S ribosomal protein S13; Region: bact_S13; TIGR03631 362663010419 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 362663010420 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 362663010421 SecY translocase; Region: SecY; pfam00344 362663010422 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 362663010423 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 362663010424 23S rRNA binding site [nucleotide binding]; other site 362663010425 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 362663010426 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 362663010427 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 362663010428 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 362663010429 23S rRNA interface [nucleotide binding]; other site 362663010430 5S rRNA interface [nucleotide binding]; other site 362663010431 L27 interface [polypeptide binding]; other site 362663010432 L5 interface [polypeptide binding]; other site 362663010433 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 362663010434 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 362663010435 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 362663010436 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 362663010437 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 362663010438 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 362663010439 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 362663010440 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 362663010441 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 362663010442 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 362663010443 RNA binding site [nucleotide binding]; other site 362663010444 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 362663010445 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 362663010446 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 362663010447 23S rRNA interface [nucleotide binding]; other site 362663010448 putative translocon interaction site; other site 362663010449 signal recognition particle (SRP54) interaction site; other site 362663010450 L23 interface [polypeptide binding]; other site 362663010451 trigger factor interaction site; other site 362663010452 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 362663010453 23S rRNA interface [nucleotide binding]; other site 362663010454 5S rRNA interface [nucleotide binding]; other site 362663010455 putative antibiotic binding site [chemical binding]; other site 362663010456 L25 interface [polypeptide binding]; other site 362663010457 L27 interface [polypeptide binding]; other site 362663010458 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 362663010459 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 362663010460 G-X-X-G motif; other site 362663010461 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 362663010462 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 362663010463 protein-rRNA interface [nucleotide binding]; other site 362663010464 putative translocon binding site; other site 362663010465 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 362663010466 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 362663010467 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 362663010468 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 362663010469 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 362663010470 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 362663010471 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 362663010472 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 362663010473 protein secretion protein GspB; Provisional; Region: PRK09697 362663010474 AAA domain; Region: AAA_22; pfam13401 362663010475 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 362663010476 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 362663010477 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 362663010478 type II secretion system protein D; Region: type_II_gspD; TIGR02517 362663010479 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663010480 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663010481 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663010482 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 362663010483 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 362663010484 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 362663010485 Walker A motif; other site 362663010486 ATP binding site [chemical binding]; other site 362663010487 Walker B motif; other site 362663010488 type II secretion system protein F; Region: GspF; TIGR02120 362663010489 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663010490 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 362663010491 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 362663010492 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 362663010493 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 362663010494 Type II transport protein GspH; Region: GspH; pfam12019 362663010495 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 362663010496 type II secretion system protein I; Region: gspI; TIGR01707 362663010497 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 362663010498 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 362663010499 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 362663010500 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 362663010501 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 362663010502 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 362663010503 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 362663010504 GspL periplasmic domain; Region: GspL_C; pfam12693 362663010505 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 362663010506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663010507 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663010508 DNA-binding interface [nucleotide binding]; DNA binding site 362663010509 Integrase core domain; Region: rve; pfam00665 362663010510 transposase/IS protein; Provisional; Region: PRK09183 362663010511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663010512 Walker A motif; other site 362663010513 ATP binding site [chemical binding]; other site 362663010514 Walker B motif; other site 362663010515 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 362663010516 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 362663010517 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 362663010518 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 362663010519 heme binding site [chemical binding]; other site 362663010520 ferroxidase pore; other site 362663010521 ferroxidase diiron center [ion binding]; other site 362663010522 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 362663010523 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 362663010524 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 362663010525 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 362663010526 aromatic chitin/cellulose binding site residues [chemical binding]; other site 362663010527 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 362663010528 active site 362663010529 elongation factor Tu; Reviewed; Region: PRK00049 362663010530 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 362663010531 G1 box; other site 362663010532 GEF interaction site [polypeptide binding]; other site 362663010533 GTP/Mg2+ binding site [chemical binding]; other site 362663010534 Switch I region; other site 362663010535 G2 box; other site 362663010536 G3 box; other site 362663010537 Switch II region; other site 362663010538 G4 box; other site 362663010539 G5 box; other site 362663010540 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 362663010541 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 362663010542 Antibiotic Binding Site [chemical binding]; other site 362663010543 elongation factor G; Reviewed; Region: PRK00007 362663010544 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 362663010545 G1 box; other site 362663010546 putative GEF interaction site [polypeptide binding]; other site 362663010547 GTP/Mg2+ binding site [chemical binding]; other site 362663010548 Switch I region; other site 362663010549 G2 box; other site 362663010550 G3 box; other site 362663010551 Switch II region; other site 362663010552 G4 box; other site 362663010553 G5 box; other site 362663010554 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 362663010555 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 362663010556 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 362663010557 30S ribosomal protein S7; Validated; Region: PRK05302 362663010558 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 362663010559 S17 interaction site [polypeptide binding]; other site 362663010560 S8 interaction site; other site 362663010561 16S rRNA interaction site [nucleotide binding]; other site 362663010562 streptomycin interaction site [chemical binding]; other site 362663010563 23S rRNA interaction site [nucleotide binding]; other site 362663010564 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 362663010565 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 362663010566 sulfur relay protein TusC; Validated; Region: PRK00211 362663010567 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 362663010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 362663010569 YheO-like PAS domain; Region: PAS_6; pfam08348 362663010570 HTH domain; Region: HTH_22; pfam13309 362663010571 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 362663010572 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 362663010573 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362663010574 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 362663010575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362663010576 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 362663010577 glutathione-regulated potassium-efflux system protein KefB nonfunction due to the frame shift 362663010578 glutathione-regulated potassium-efflux system protein KefB nonfunction due to the frame shift 362663010579 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 362663010580 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 362663010581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663010582 Walker A/P-loop; other site 362663010583 ATP binding site [chemical binding]; other site 362663010584 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663010585 ABC transporter signature motif; other site 362663010586 Walker B; other site 362663010587 D-loop; other site 362663010588 ABC transporter; Region: ABC_tran_2; pfam12848 362663010589 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663010590 putative hydrolase; Provisional; Region: PRK10985 362663010591 hypothetical protein; Provisional; Region: PRK04966 362663010592 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 362663010593 active site 362663010594 hypothetical protein; Provisional; Region: PRK10738 362663010595 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 362663010596 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 362663010597 ligand binding site [chemical binding]; other site 362663010598 flexible hinge region; other site 362663010599 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 362663010600 putative switch regulator; other site 362663010601 non-specific DNA interactions [nucleotide binding]; other site 362663010602 DNA binding site [nucleotide binding] 362663010603 sequence specific DNA binding site [nucleotide binding]; other site 362663010604 putative cAMP binding site [chemical binding]; other site 362663010605 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 362663010606 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 362663010607 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663010608 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 362663010609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 362663010610 inhibitor-cofactor binding pocket; inhibition site 362663010611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663010612 catalytic residue [active] 362663010613 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 362663010614 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 362663010615 glutamine binding [chemical binding]; other site 362663010616 catalytic triad [active] 362663010617 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 362663010618 cell filamentation protein Fic; Provisional; Region: PRK10347 362663010619 hypothetical protein; Provisional; Region: PRK10204 362663010620 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 362663010621 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 362663010622 substrate binding site [chemical binding]; other site 362663010623 putative transporter; Provisional; Region: PRK03699 362663010624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663010625 putative substrate translocation pore; other site 362663010626 nitrite reductase subunit NirD; Provisional; Region: PRK14989 362663010627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663010628 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 362663010629 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 362663010630 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 362663010631 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 362663010632 nitrite transporter NirC; Provisional; Region: PRK11562 362663010633 siroheme synthase; Provisional; Region: cysG; PRK10637 362663010634 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 362663010635 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 362663010636 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 362663010637 active site 362663010638 SAM binding site [chemical binding]; other site 362663010639 homodimer interface [polypeptide binding]; other site 362663010640 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 362663010641 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 362663010642 Protein of unknown function; Region: YhfT; pfam10797 362663010643 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 362663010644 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 362663010645 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 362663010646 active site 362663010647 substrate binding pocket [chemical binding]; other site 362663010648 homodimer interaction site [polypeptide binding]; other site 362663010649 putative mutase; Provisional; Region: PRK12383 362663010650 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 362663010651 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 362663010652 dimer interface [polypeptide binding]; other site 362663010653 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 362663010654 active site 362663010655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663010656 substrate binding site [chemical binding]; other site 362663010657 catalytic residue [active] 362663010658 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 362663010659 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 362663010660 active site 362663010661 HIGH motif; other site 362663010662 dimer interface [polypeptide binding]; other site 362663010663 KMSKS motif; other site 362663010664 phosphoglycolate phosphatase; Provisional; Region: PRK13222 362663010665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663010666 motif II; other site 362663010667 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 362663010668 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 362663010669 substrate binding site [chemical binding]; other site 362663010670 hexamer interface [polypeptide binding]; other site 362663010671 metal binding site [ion binding]; metal-binding site 362663010672 DNA adenine methylase; Provisional; Region: PRK10904 362663010673 DamX protein nonfunction due to the frame shift 362663010674 DamX protein nonfunction due to the frame shift 362663010675 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 362663010676 active site 362663010677 dimer interface [polypeptide binding]; other site 362663010678 metal binding site [ion binding]; metal-binding site 362663010679 shikimate kinase; Reviewed; Region: aroK; PRK00131 362663010680 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 362663010681 ADP binding site [chemical binding]; other site 362663010682 magnesium binding site [ion binding]; other site 362663010683 putative shikimate binding site; other site 362663010684 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 362663010685 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 362663010686 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 362663010687 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 362663010688 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 362663010689 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 362663010690 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 362663010691 Transglycosylase; Region: Transgly; pfam00912 362663010692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 362663010693 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 362663010694 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 362663010695 ADP-ribose binding site [chemical binding]; other site 362663010696 dimer interface [polypeptide binding]; other site 362663010697 active site 362663010698 nudix motif; other site 362663010699 metal binding site [ion binding]; metal-binding site 362663010700 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 362663010701 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 362663010702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663010703 motif II; other site 362663010704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663010705 RNA binding surface [nucleotide binding]; other site 362663010706 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 362663010707 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 362663010708 dimerization interface [polypeptide binding]; other site 362663010709 domain crossover interface; other site 362663010710 redox-dependent activation switch; other site 362663010711 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 362663010712 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 362663010713 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 362663010714 active site 362663010715 substrate-binding site [chemical binding]; other site 362663010716 metal-binding site [ion binding] 362663010717 ATP binding site [chemical binding]; other site 362663010718 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 362663010719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663010720 dimerization interface [polypeptide binding]; other site 362663010721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663010722 dimer interface [polypeptide binding]; other site 362663010723 phosphorylation site [posttranslational modification] 362663010724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663010725 ATP binding site [chemical binding]; other site 362663010726 G-X-G motif; other site 362663010727 osmolarity response regulator; Provisional; Region: ompR; PRK09468 362663010728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663010729 active site 362663010730 phosphorylation site [posttranslational modification] 362663010731 intermolecular recognition site; other site 362663010732 dimerization interface [polypeptide binding]; other site 362663010733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663010734 DNA binding site [nucleotide binding] 362663010735 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 362663010736 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 362663010737 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 362663010738 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 362663010739 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 362663010740 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 362663010741 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 362663010742 RNA binding site [nucleotide binding]; other site 362663010743 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 362663010744 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 362663010745 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 362663010746 G1 box; other site 362663010747 GTP/Mg2+ binding site [chemical binding]; other site 362663010748 Switch I region; other site 362663010749 G2 box; other site 362663010750 G3 box; other site 362663010751 Switch II region; other site 362663010752 G4 box; other site 362663010753 G5 box; other site 362663010754 Nucleoside recognition; Region: Gate; pfam07670 362663010755 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 362663010756 Nucleoside recognition; Region: Gate; pfam07670 362663010757 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 362663010758 putative transposase; Provisional; Region: PRK09857 362663010759 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 362663010760 carboxylesterase BioH; Provisional; Region: PRK10349 362663010761 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 362663010762 DNA utilization protein GntX; Provisional; Region: PRK11595 362663010763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663010764 active site 362663010765 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 362663010766 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 362663010767 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 362663010768 high-affinity gluconate transporter; Provisional; Region: PRK14984 362663010769 gluconate transporter; Region: gntP; TIGR00791 362663010770 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 362663010771 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 362663010772 maltodextrin phosphorylase; Provisional; Region: PRK14985 362663010773 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 362663010774 homodimer interface [polypeptide binding]; other site 362663010775 active site pocket [active] 362663010776 transcriptional regulator MalT; Provisional; Region: PRK04841 362663010777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663010778 DNA binding residues [nucleotide binding] 362663010779 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 362663010780 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 362663010781 putative active site [active] 362663010782 adenylation catalytic residue [active] 362663010783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 362663010784 hypothetical protein; Reviewed; Region: PRK09588 362663010785 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 362663010786 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 362663010787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663010788 Walker A motif; other site 362663010789 ATP binding site [chemical binding]; other site 362663010790 Walker B motif; other site 362663010791 arginine finger; other site 362663010792 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 362663010793 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 362663010794 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663010795 intramembrane serine protease GlpG; Provisional; Region: PRK10907 362663010796 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 362663010797 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 362663010798 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 362663010799 active site residue [active] 362663010800 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 362663010801 hypothetical protein; Provisional; Region: PRK09781; cl08057 362663010802 Fimbrial protein; Region: Fimbrial; cl01416 362663010803 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 362663010804 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663010805 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663010806 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663010807 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663010808 outer membrane usher protein; Provisional; Region: PRK15193 362663010809 PapC N-terminal domain; Region: PapC_N; pfam13954 362663010810 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663010811 PapC C-terminal domain; Region: PapC_C; pfam13953 362663010812 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 362663010813 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663010814 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663010815 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663010816 glycogen phosphorylase; Provisional; Region: PRK14986 362663010817 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 362663010818 homodimer interface [polypeptide binding]; other site 362663010819 active site pocket [active] 362663010820 glycogen synthase; Provisional; Region: glgA; PRK00654 362663010821 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 362663010822 ADP-binding pocket [chemical binding]; other site 362663010823 homodimer interface [polypeptide binding]; other site 362663010824 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 362663010825 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 362663010826 ligand binding site; other site 362663010827 oligomer interface; other site 362663010828 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 362663010829 sulfate 1 binding site; other site 362663010830 glycogen debranching enzyme; Provisional; Region: PRK03705 362663010831 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 362663010832 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 362663010833 active site 362663010834 catalytic site [active] 362663010835 glycogen branching enzyme; Provisional; Region: PRK05402 362663010836 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 362663010837 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 362663010838 active site 362663010839 catalytic site [active] 362663010840 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 362663010841 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 362663010842 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 362663010843 putative antibiotic transporter; Provisional; Region: PRK10739 362663010844 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 362663010845 DNA protecting protein DprA; Region: dprA; TIGR00732 362663010846 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 362663010847 non-specific DNA interactions [nucleotide binding]; other site 362663010848 DNA binding site [nucleotide binding] 362663010849 sequence specific DNA binding site [nucleotide binding]; other site 362663010850 putative cAMP binding site [chemical binding]; other site 362663010851 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 362663010852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663010853 ATP binding site [chemical binding]; other site 362663010854 putative Mg++ binding site [ion binding]; other site 362663010855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663010856 nucleotide binding region [chemical binding]; other site 362663010857 ATP-binding site [chemical binding]; other site 362663010858 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663010859 active site 362663010860 low affinity gluconate transporter; Provisional; Region: PRK10472 362663010861 gluconate transporter; Region: gntP; TIGR00791 362663010862 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 362663010863 Shikimate kinase; Region: SKI; pfam01202 362663010864 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 362663010865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663010866 DNA binding site [nucleotide binding] 362663010867 domain linker motif; other site 362663010868 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 362663010869 putative ligand binding site [chemical binding]; other site 362663010870 putative dimerization interface [polypeptide binding]; other site 362663010871 Pirin-related protein [General function prediction only]; Region: COG1741 362663010872 Pirin; Region: Pirin; pfam02678 362663010873 putative oxidoreductase; Provisional; Region: PRK10206 362663010874 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 362663010875 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 362663010876 putative acetyltransferase YhhY; Provisional; Region: PRK10140 362663010877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663010878 Coenzyme A binding pocket [chemical binding]; other site 362663010879 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 362663010880 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 362663010881 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 362663010882 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 362663010883 hypothetical protein; Provisional; Region: PRK10350 362663010884 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 362663010885 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 362663010886 putative active site [active] 362663010887 catalytic site [active] 362663010888 putative metal binding site [ion binding]; other site 362663010889 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 362663010890 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 362663010891 Walker A/P-loop; other site 362663010892 ATP binding site [chemical binding]; other site 362663010893 Q-loop/lid; other site 362663010894 ABC transporter signature motif; other site 362663010895 Walker B; other site 362663010896 D-loop; other site 362663010897 H-loop/switch region; other site 362663010898 TOBE domain; Region: TOBE_2; pfam08402 362663010899 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 362663010900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663010901 dimer interface [polypeptide binding]; other site 362663010902 conserved gate region; other site 362663010903 putative PBP binding loops; other site 362663010904 ABC-ATPase subunit interface; other site 362663010905 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 362663010906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663010907 dimer interface [polypeptide binding]; other site 362663010908 conserved gate region; other site 362663010909 putative PBP binding loops; other site 362663010910 ABC-ATPase subunit interface; other site 362663010911 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 362663010912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 362663010913 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 362663010914 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 362663010915 Walker A/P-loop; other site 362663010916 ATP binding site [chemical binding]; other site 362663010917 Q-loop/lid; other site 362663010918 ABC transporter signature motif; other site 362663010919 Walker B; other site 362663010920 D-loop; other site 362663010921 H-loop/switch region; other site 362663010922 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 362663010923 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 362663010924 Walker A/P-loop; other site 362663010925 ATP binding site [chemical binding]; other site 362663010926 Q-loop/lid; other site 362663010927 ABC transporter signature motif; other site 362663010928 Walker B; other site 362663010929 D-loop; other site 362663010930 H-loop/switch region; other site 362663010931 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 362663010932 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 362663010933 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 362663010934 TM-ABC transporter signature motif; other site 362663010935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663010936 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 362663010937 TM-ABC transporter signature motif; other site 362663010938 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 362663010939 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 362663010940 dimerization interface [polypeptide binding]; other site 362663010941 ligand binding site [chemical binding]; other site 362663010942 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 362663010943 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 362663010944 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 362663010945 dimerization interface [polypeptide binding]; other site 362663010946 ligand binding site [chemical binding]; other site 362663010947 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 362663010948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 362663010949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 362663010950 DNA binding residues [nucleotide binding] 362663010951 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 362663010952 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 362663010953 cell division protein FtsE; Provisional; Region: PRK10908 362663010954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663010955 Walker A/P-loop; other site 362663010956 ATP binding site [chemical binding]; other site 362663010957 Q-loop/lid; other site 362663010958 ABC transporter signature motif; other site 362663010959 Walker B; other site 362663010960 D-loop; other site 362663010961 H-loop/switch region; other site 362663010962 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 362663010963 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 362663010964 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 362663010965 P loop; other site 362663010966 GTP binding site [chemical binding]; other site 362663010967 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 362663010968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663010969 S-adenosylmethionine binding site [chemical binding]; other site 362663010970 hypothetical protein; Provisional; Region: PRK10910 362663010971 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 362663010972 Predicted membrane protein [Function unknown]; Region: COG3714 362663010973 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 362663010974 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 362663010975 metal-binding site [ion binding] 362663010976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362663010977 HTH-like domain; Region: HTH_21; pfam13276 362663010978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 362663010979 Integrase core domain; Region: rve; pfam00665 362663010980 Integrase core domain; Region: rve_2; pfam13333 362663010981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663010982 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663010983 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663010984 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 362663010985 CPxP motif; other site 362663010986 hypothetical protein; Provisional; Region: PRK11212 362663010987 hypothetical protein; Provisional; Region: PRK11615 362663010988 major facilitator superfamily transporter; Provisional; Region: PRK05122 362663010989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663010990 putative substrate translocation pore; other site 362663010991 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 362663010992 Domain of unknown function DUF20; Region: UPF0118; pfam01594 362663010993 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 362663010994 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 362663010995 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 362663010996 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 362663010997 substrate binding site [chemical binding]; other site 362663010998 nickel transporter permease NikB; Provisional; Region: PRK10352 362663010999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663011000 dimer interface [polypeptide binding]; other site 362663011001 conserved gate region; other site 362663011002 putative PBP binding loops; other site 362663011003 ABC-ATPase subunit interface; other site 362663011004 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 362663011005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663011006 dimer interface [polypeptide binding]; other site 362663011007 conserved gate region; other site 362663011008 putative PBP binding loops; other site 362663011009 ABC-ATPase subunit interface; other site 362663011010 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 362663011011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663011012 Walker A/P-loop; other site 362663011013 ATP binding site [chemical binding]; other site 362663011014 Q-loop/lid; other site 362663011015 ABC transporter signature motif; other site 362663011016 Walker B; other site 362663011017 D-loop; other site 362663011018 H-loop/switch region; other site 362663011019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362663011020 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 362663011021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663011022 Walker A/P-loop; other site 362663011023 ATP binding site [chemical binding]; other site 362663011024 Q-loop/lid; other site 362663011025 ABC transporter signature motif; other site 362663011026 Walker B; other site 362663011027 D-loop; other site 362663011028 H-loop/switch region; other site 362663011029 nickel responsive regulator; Provisional; Region: PRK02967 362663011030 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 362663011031 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362663011032 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 362663011033 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362663011034 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 362663011035 Walker A/P-loop; other site 362663011036 ATP binding site [chemical binding]; other site 362663011037 Q-loop/lid; other site 362663011038 ABC transporter signature motif; other site 362663011039 Walker B; other site 362663011040 D-loop; other site 362663011041 H-loop/switch region; other site 362663011042 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 362663011043 Walker A/P-loop; other site 362663011044 ATP binding site [chemical binding]; other site 362663011045 Q-loop/lid; other site 362663011046 ABC transporter signature motif; other site 362663011047 Walker B; other site 362663011048 D-loop; other site 362663011049 H-loop/switch region; other site 362663011050 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 362663011051 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 362663011052 HlyD family secretion protein; Region: HlyD; pfam00529 362663011053 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663011054 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663011055 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 362663011056 Predicted flavoproteins [General function prediction only]; Region: COG2081 362663011057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663011058 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 362663011059 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 362663011060 universal stress protein UspB; Provisional; Region: PRK04960 362663011061 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663011062 Ligand Binding Site [chemical binding]; other site 362663011063 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 362663011064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011065 POT family; Region: PTR2; pfam00854 362663011066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663011067 S-adenosylmethionine binding site [chemical binding]; other site 362663011068 oligopeptidase A; Provisional; Region: PRK10911 362663011069 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 362663011070 active site 362663011071 Zn binding site [ion binding]; other site 362663011072 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 362663011073 glutathione reductase; Validated; Region: PRK06116 362663011074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 362663011075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663011076 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 362663011077 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 362663011078 ArsC family; Region: ArsC; pfam03960 362663011079 catalytic residues [active] 362663011080 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 362663011081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663011082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663011083 DNA binding residues [nucleotide binding] 362663011084 dimerization interface [polypeptide binding]; other site 362663011085 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 362663011086 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 362663011087 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 362663011088 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 362663011089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663011090 N-terminal plug; other site 362663011091 ligand-binding site [chemical binding]; other site 362663011092 Uncharacterized conserved protein [Function unknown]; Region: COG5644 362663011093 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 362663011094 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 362663011095 putative hemin binding site; other site 362663011096 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 362663011097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663011098 FeS/SAM binding site; other site 362663011099 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 362663011100 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 362663011101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 362663011102 NAD(P) binding site [chemical binding]; other site 362663011103 putative active site [active] 362663011104 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 362663011105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663011106 ABC-ATPase subunit interface; other site 362663011107 dimer interface [polypeptide binding]; other site 362663011108 putative PBP binding regions; other site 362663011109 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 362663011110 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 362663011111 Walker A/P-loop; other site 362663011112 ATP binding site [chemical binding]; other site 362663011113 Q-loop/lid; other site 362663011114 ABC transporter signature motif; other site 362663011115 Walker B; other site 362663011116 D-loop; other site 362663011117 H-loop/switch region; other site 362663011118 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 362663011119 MgtC family; Region: MgtC; pfam02308 362663011120 acid-resistance protein; Provisional; Region: hdeB; PRK11566 362663011121 acid-resistance protein; Provisional; Region: PRK10208 362663011122 acid-resistance membrane protein; Provisional; Region: PRK10209 362663011123 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 362663011124 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 362663011125 pyruvate kinase; Provisional; Region: PRK05826 362663011126 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 362663011127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663011128 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663011129 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 362663011130 Protein export membrane protein; Region: SecD_SecF; cl14618 362663011131 transcriptional regulator YdeO; Provisional; Region: PRK09940 362663011132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011133 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 362663011134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011135 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 362663011136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663011137 catalytic residue [active] 362663011138 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 362663011139 Haem-binding domain; Region: Haem_bd; pfam14376 362663011140 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 362663011141 trehalase; Provisional; Region: treF; PRK13270 362663011142 Trehalase; Region: Trehalase; pfam01204 362663011143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663011144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663011145 DNA binding residues [nucleotide binding] 362663011146 dimerization interface [polypeptide binding]; other site 362663011147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663011148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663011149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663011150 dimerization interface [polypeptide binding]; other site 362663011151 inner membrane protein YhjD; Region: TIGR00766 362663011152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011153 metabolite-proton symporter; Region: 2A0106; TIGR00883 362663011154 putative substrate translocation pore; other site 362663011155 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 362663011156 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 362663011157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663011158 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663011159 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 362663011160 substrate binding site [chemical binding]; other site 362663011161 ATP binding site [chemical binding]; other site 362663011162 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 362663011163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 362663011164 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 362663011165 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 362663011166 putative diguanylate cyclase; Provisional; Region: PRK13561 362663011167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 362663011168 metal binding site [ion binding]; metal-binding site 362663011169 active site 362663011170 I-site; other site 362663011171 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663011172 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 362663011173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663011174 binding surface 362663011175 TPR motif; other site 362663011176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663011177 binding surface 362663011178 TPR motif; other site 362663011179 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 362663011180 endo-1,4-D-glucanase; Provisional; Region: PRK11097 362663011181 cellulose synthase regulator protein; Provisional; Region: PRK11114 362663011182 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 362663011183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 362663011184 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 362663011185 DXD motif; other site 362663011186 PilZ domain; Region: PilZ; pfam07238 362663011187 cell division protein; Provisional; Region: PRK10037 362663011188 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 362663011189 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 362663011190 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 362663011191 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 362663011192 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 362663011193 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 362663011194 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 362663011195 serine transporter; Region: stp; TIGR00814 362663011196 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 362663011197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663011198 Walker A/P-loop; other site 362663011199 ATP binding site [chemical binding]; other site 362663011200 Q-loop/lid; other site 362663011201 ABC transporter signature motif; other site 362663011202 Walker B; other site 362663011203 D-loop; other site 362663011204 H-loop/switch region; other site 362663011205 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 362663011206 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 362663011207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663011208 Walker A/P-loop; other site 362663011209 ATP binding site [chemical binding]; other site 362663011210 Q-loop/lid; other site 362663011211 ABC transporter signature motif; other site 362663011212 Walker B; other site 362663011213 D-loop; other site 362663011214 H-loop/switch region; other site 362663011215 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 362663011216 dipeptide transporter; Provisional; Region: PRK10913 362663011217 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362663011218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663011219 dimer interface [polypeptide binding]; other site 362663011220 conserved gate region; other site 362663011221 putative PBP binding loops; other site 362663011222 ABC-ATPase subunit interface; other site 362663011223 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 362663011224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663011225 dimer interface [polypeptide binding]; other site 362663011226 conserved gate region; other site 362663011227 putative PBP binding loops; other site 362663011228 ABC-ATPase subunit interface; other site 362663011229 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 362663011230 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 362663011231 peptide binding site [polypeptide binding]; other site 362663011232 phosphoethanolamine transferase; Provisional; Region: PRK11560 362663011233 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 362663011234 Sulfatase; Region: Sulfatase; pfam00884 362663011235 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 362663011236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011237 putative substrate translocation pore; other site 362663011238 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 362663011239 DNA-3-methyladenine glycosylase nonfunction due to the frame shift 362663011240 DNA-3-methyladenine glycosylase nonfunction due to the frame shift 362663011241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362663011242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663011243 Coenzyme A binding pocket [chemical binding]; other site 362663011244 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 362663011245 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 362663011246 molybdopterin cofactor binding site [chemical binding]; other site 362663011247 substrate binding site [chemical binding]; other site 362663011248 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 362663011249 molybdopterin cofactor binding site; other site 362663011250 putative outer membrane lipoprotein; Provisional; Region: PRK10510 362663011251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 362663011252 ligand binding site [chemical binding]; other site 362663011253 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 362663011254 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 362663011255 dimerization interface [polypeptide binding]; other site 362663011256 ligand binding site [chemical binding]; other site 362663011257 NADP binding site [chemical binding]; other site 362663011258 catalytic site [active] 362663011259 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 362663011260 Predicted transcriptional regulator [Transcription]; Region: COG2944 362663011261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663011262 non-specific DNA binding site [nucleotide binding]; other site 362663011263 salt bridge; other site 362663011264 sequence-specific DNA binding site [nucleotide binding]; other site 362663011265 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 362663011266 DNA-binding site [nucleotide binding]; DNA binding site 362663011267 RNA-binding motif; other site 362663011268 small toxic polypeptide; Provisional; Region: PRK09759 362663011269 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 362663011270 DALR anticodon binding domain; Region: DALR_1; pfam05746 362663011271 anticodon binding site; other site 362663011272 tRNA binding surface [nucleotide binding]; other site 362663011273 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 362663011274 dimer interface [polypeptide binding]; other site 362663011275 motif 1; other site 362663011276 active site 362663011277 motif 2; other site 362663011278 motif 3; other site 362663011279 YsaB-like lipoprotein; Region: YsaB; pfam13983 362663011280 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 362663011281 Acyltransferase family; Region: Acyl_transf_3; pfam01757 362663011282 hypothetical protein; Provisional; Region: PRK11383 362663011283 yiaA/B two helix domain; Region: YiaAB; pfam05360 362663011284 yiaA/B two helix domain; Region: YiaAB; pfam05360 362663011285 hypothetical protein; Provisional; Region: PRK11403 362663011286 yiaA/B two helix domain; Region: YiaAB; pfam05360 362663011287 xylulokinase; Provisional; Region: PRK15027 362663011288 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 362663011289 N- and C-terminal domain interface [polypeptide binding]; other site 362663011290 active site 362663011291 MgATP binding site [chemical binding]; other site 362663011292 catalytic site [active] 362663011293 metal binding site [ion binding]; metal-binding site 362663011294 xylulose binding site [chemical binding]; other site 362663011295 homodimer interface [polypeptide binding]; other site 362663011296 xylose isomerase; Provisional; Region: PRK05474 362663011297 xylose isomerase; Region: xylose_isom_A; TIGR02630 362663011298 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 362663011299 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 362663011300 putative ligand binding site [chemical binding]; other site 362663011301 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 362663011302 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663011303 Walker A/P-loop; other site 362663011304 ATP binding site [chemical binding]; other site 362663011305 Q-loop/lid; other site 362663011306 ABC transporter signature motif; other site 362663011307 Walker B; other site 362663011308 D-loop; other site 362663011309 H-loop/switch region; other site 362663011310 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663011311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663011312 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663011313 TM-ABC transporter signature motif; other site 362663011314 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 362663011315 putative dimerization interface [polypeptide binding]; other site 362663011316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 362663011317 putative ligand binding site [chemical binding]; other site 362663011318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011319 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663011320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011321 hypothetical protein; Provisional; Region: PRK10356 362663011322 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 362663011323 alpha-amylase; Reviewed; Region: malS; PRK09505 362663011324 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 362663011325 active site 362663011326 catalytic site [active] 362663011327 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 362663011328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663011329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663011330 homodimer interface [polypeptide binding]; other site 362663011331 catalytic residue [active] 362663011332 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 362663011333 Transcriptional regulator [Transcription]; Region: IclR; COG1414 362663011334 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 362663011335 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663011336 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 362663011337 Domain of unknown function (DUF386); Region: DUF386; pfam04074 362663011338 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 362663011339 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 362663011340 DctM-like transporters; Region: DctM; pfam06808 362663011341 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 362663011342 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 362663011343 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 362663011344 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 362663011345 putative N- and C-terminal domain interface [polypeptide binding]; other site 362663011346 putative active site [active] 362663011347 MgATP binding site [chemical binding]; other site 362663011348 catalytic site [active] 362663011349 metal binding site [ion binding]; metal-binding site 362663011350 putative xylulose binding site [chemical binding]; other site 362663011351 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 362663011352 active site 362663011353 dimer interface [polypeptide binding]; other site 362663011354 magnesium binding site [ion binding]; other site 362663011355 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 362663011356 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 362663011357 AP (apurinic/apyrimidinic) site pocket; other site 362663011358 DNA interaction; other site 362663011359 Metal-binding active site; metal-binding site 362663011360 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 362663011361 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 362663011362 intersubunit interface [polypeptide binding]; other site 362663011363 active site 362663011364 Zn2+ binding site [ion binding]; other site 362663011365 aldehyde dehydrogenase B nonfunction due to the frame shift 362663011366 aldehyde dehydrogenase B nonfunction due to the frame shift 362663011367 putative alcohol dehydrogenase; Provisional; Region: PRK09860 362663011368 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 362663011369 dimer interface [polypeptide binding]; other site 362663011370 active site 362663011371 metal binding site [ion binding]; metal-binding site 362663011372 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 362663011373 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 362663011374 G1 box; other site 362663011375 putative GEF interaction site [polypeptide binding]; other site 362663011376 GTP/Mg2+ binding site [chemical binding]; other site 362663011377 Switch I region; other site 362663011378 G2 box; other site 362663011379 G3 box; other site 362663011380 Switch II region; other site 362663011381 G4 box; other site 362663011382 G5 box; other site 362663011383 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 362663011384 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 362663011385 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 362663011386 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 362663011387 selenocysteine synthase; Provisional; Region: PRK04311 362663011388 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 362663011389 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 362663011390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663011391 catalytic residue [active] 362663011392 putative glutathione S-transferase; Provisional; Region: PRK10357 362663011393 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 362663011394 putative C-terminal domain interface [polypeptide binding]; other site 362663011395 putative GSH binding site (G-site) [chemical binding]; other site 362663011396 putative dimer interface [polypeptide binding]; other site 362663011397 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 362663011398 dimer interface [polypeptide binding]; other site 362663011399 N-terminal domain interface [polypeptide binding]; other site 362663011400 putative substrate binding pocket (H-site) [chemical binding]; other site 362663011401 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 362663011402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663011403 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663011404 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 362663011405 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 362663011406 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 362663011407 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 362663011408 active site 362663011409 P-loop; other site 362663011410 phosphorylation site [posttranslational modification] 362663011411 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663011412 active site 362663011413 phosphorylation site [posttranslational modification] 362663011414 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 362663011415 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663011416 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663011417 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 362663011418 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 362663011419 hypothetical protein; Provisional; Region: PRK11020 362663011420 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 362663011421 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 362663011422 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 362663011423 trimer interface [polypeptide binding]; other site 362663011424 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 362663011425 trimer interface [polypeptide binding]; other site 362663011426 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 362663011427 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 362663011428 trimer interface [polypeptide binding]; other site 362663011429 Haemagglutinin; Region: HIM; pfam05662 362663011430 Haemagglutinin; Region: HIM; pfam05662 362663011431 YadA-like C-terminal region; Region: YadA; pfam03895 362663011432 L-lactate permease; Provisional; Region: PRK10420 362663011433 glycolate transporter; Provisional; Region: PRK09695 362663011434 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 362663011435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663011436 DNA-binding site [nucleotide binding]; DNA binding site 362663011437 FCD domain; Region: FCD; pfam07729 362663011438 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 362663011439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 362663011440 phosphate binding site [ion binding]; other site 362663011441 putative rRNA methylase; Provisional; Region: PRK10358 362663011442 serine acetyltransferase; Provisional; Region: cysE; PRK11132 362663011443 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 362663011444 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 362663011445 trimer interface [polypeptide binding]; other site 362663011446 active site 362663011447 substrate binding site [chemical binding]; other site 362663011448 CoA binding site [chemical binding]; other site 362663011449 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 362663011450 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 362663011451 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 362663011452 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 362663011453 SecA binding site; other site 362663011454 Preprotein binding site; other site 362663011455 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 362663011456 GSH binding site [chemical binding]; other site 362663011457 catalytic residues [active] 362663011458 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 362663011459 active site residue [active] 362663011460 phosphoglyceromutase; Provisional; Region: PRK05434 362663011461 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 362663011462 AmiB activator; Provisional; Region: PRK11637 362663011463 Peptidase family M23; Region: Peptidase_M23; pfam01551 362663011464 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 362663011465 NodB motif; other site 362663011466 putative active site [active] 362663011467 putative catalytic site [active] 362663011468 Zn binding site [ion binding]; other site 362663011469 putative glycosyl transferase; Provisional; Region: PRK10073 362663011470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362663011471 active site 362663011472 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 362663011473 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 362663011474 NAD(P) binding site [chemical binding]; other site 362663011475 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 362663011476 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 362663011477 substrate-cofactor binding pocket; other site 362663011478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663011479 catalytic residue [active] 362663011480 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 362663011481 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 362663011482 NADP binding site [chemical binding]; other site 362663011483 homopentamer interface [polypeptide binding]; other site 362663011484 substrate binding site [chemical binding]; other site 362663011485 active site 362663011486 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 362663011487 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 362663011488 putative active site [active] 362663011489 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 362663011490 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 362663011491 putative active site [active] 362663011492 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 362663011493 O-Antigen ligase; Region: Wzy_C; pfam04932 362663011494 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 362663011495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 362663011496 active site 362663011497 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 362663011498 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 362663011499 Ligand binding site; other site 362663011500 metal-binding site 362663011501 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 362663011502 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 362663011503 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 362663011504 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 362663011505 Ligand binding site; other site 362663011506 metal-binding site 362663011507 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 362663011508 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 362663011509 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 362663011510 Ligand binding site; other site 362663011511 metal-binding site 362663011512 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 362663011513 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 362663011514 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 362663011515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 362663011516 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 362663011517 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 362663011518 putative active site [active] 362663011519 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 362663011520 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 362663011521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 362663011522 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 362663011523 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 362663011524 active site 362663011525 (T/H)XGH motif; other site 362663011526 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 362663011527 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 362663011528 DNA binding site [nucleotide binding] 362663011529 catalytic residue [active] 362663011530 H2TH interface [polypeptide binding]; other site 362663011531 putative catalytic residues [active] 362663011532 turnover-facilitating residue; other site 362663011533 intercalation triad [nucleotide binding]; other site 362663011534 8OG recognition residue [nucleotide binding]; other site 362663011535 putative reading head residues; other site 362663011536 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 362663011537 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 362663011538 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 362663011539 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 362663011540 hypothetical protein; Reviewed; Region: PRK00024 362663011541 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663011542 MPN+ (JAMM) motif; other site 362663011543 Zinc-binding site [ion binding]; other site 362663011544 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 362663011545 Flavoprotein; Region: Flavoprotein; pfam02441 362663011546 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 362663011547 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 362663011548 trimer interface [polypeptide binding]; other site 362663011549 active site 362663011550 division inhibitor protein; Provisional; Region: slmA; PRK09480 362663011551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663011552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 362663011553 active site 362663011554 ribonuclease PH; Reviewed; Region: rph; PRK00173 362663011555 Ribonuclease PH; Region: RNase_PH_bact; cd11362 362663011556 hexamer interface [polypeptide binding]; other site 362663011557 active site 362663011558 hypothetical protein; Provisional; Region: PRK11820 362663011559 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 362663011560 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 362663011561 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 362663011562 BRO family, N-terminal domain; Region: Bro-N; pfam02498 362663011563 Predicted membrane protein [Function unknown]; Region: COG2860 362663011564 UPF0126 domain; Region: UPF0126; pfam03458 362663011565 UPF0126 domain; Region: UPF0126; pfam03458 362663011566 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 362663011567 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 362663011568 nucleotide binding pocket [chemical binding]; other site 362663011569 K-X-D-G motif; other site 362663011570 catalytic site [active] 362663011571 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 362663011572 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 362663011573 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 362663011574 catalytic site [active] 362663011575 G-X2-G-X-G-K; other site 362663011576 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 362663011577 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 362663011578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 362663011579 Zn2+ binding site [ion binding]; other site 362663011580 Mg2+ binding site [ion binding]; other site 362663011581 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 362663011582 synthetase active site [active] 362663011583 NTP binding site [chemical binding]; other site 362663011584 metal binding site [ion binding]; metal-binding site 362663011585 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 362663011586 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 362663011587 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 362663011588 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 362663011589 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 362663011590 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 362663011591 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 362663011592 generic binding surface II; other site 362663011593 ssDNA binding site; other site 362663011594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663011595 ATP binding site [chemical binding]; other site 362663011596 putative Mg++ binding site [ion binding]; other site 362663011597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663011598 nucleotide binding region [chemical binding]; other site 362663011599 ATP-binding site [chemical binding]; other site 362663011600 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 362663011601 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 362663011602 AsmA family; Region: AsmA; pfam05170 362663011603 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 362663011604 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 362663011605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 362663011606 fructokinase; Reviewed; Region: PRK09557 362663011607 nucleotide binding site [chemical binding]; other site 362663011608 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362663011609 intersubunit interface [polypeptide binding]; other site 362663011610 active site 362663011611 zinc binding site [ion binding]; other site 362663011612 Na+ binding site [ion binding]; other site 362663011613 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 362663011614 intersubunit interface [polypeptide binding]; other site 362663011615 active site 362663011616 zinc binding site [ion binding]; other site 362663011617 Na+ binding site [ion binding]; other site 362663011618 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 362663011619 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362663011620 active site 362663011621 P-loop; other site 362663011622 phosphorylation site [posttranslational modification] 362663011623 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663011624 active site 362663011625 phosphorylation site [posttranslational modification] 362663011626 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 362663011627 HTH domain; Region: HTH_11; pfam08279 362663011628 Mga helix-turn-helix domain; Region: Mga; pfam05043 362663011629 PRD domain; Region: PRD; pfam00874 362663011630 PRD domain; Region: PRD; pfam00874 362663011631 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 362663011632 active site 362663011633 P-loop; other site 362663011634 phosphorylation site [posttranslational modification] 362663011635 putative alpha-glucosidase; Provisional; Region: PRK10658 362663011636 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 362663011637 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 362663011638 active site 362663011639 homotrimer interface [polypeptide binding]; other site 362663011640 catalytic site [active] 362663011641 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 362663011642 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 362663011643 putative transporter; Provisional; Region: PRK11462 362663011644 integrase; Provisional; Region: PRK09692 362663011645 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663011646 active site 362663011647 Int/Topo IB signature motif; other site 362663011648 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 362663011649 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 362663011650 cofactor binding site; other site 362663011651 DNA binding site [nucleotide binding] 362663011652 substrate interaction site [chemical binding]; other site 362663011653 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 362663011654 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 362663011655 cofactor binding site; other site 362663011656 DNA binding site [nucleotide binding] 362663011657 substrate interaction site [chemical binding]; other site 362663011658 HNH endonuclease; Region: HNH_2; pfam13391 362663011659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663011660 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663011661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663011662 Integrase core domain; Region: rve; pfam00665 362663011663 transposase/IS protein; Provisional; Region: PRK09183 362663011664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663011665 Walker A motif; other site 362663011666 ATP binding site [chemical binding]; other site 362663011667 Walker B motif; other site 362663011668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663011669 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663011670 DNA-binding interface [nucleotide binding]; DNA binding site 362663011671 Integrase core domain; Region: rve; pfam00665 362663011672 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 362663011673 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 362663011674 MarR family; Region: MarR_2; cl17246 362663011675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663011676 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663011677 PapC N-terminal domain; Region: PapC_N; pfam13954 362663011678 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 362663011679 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663011680 PapC C-terminal domain; Region: PapC_C; pfam13953 362663011681 putative chaperone protein EcpD; Provisional; Region: PRK09926 362663011682 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663011683 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663011684 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663011685 Predicted membrane protein [Function unknown]; Region: COG2259 362663011686 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 362663011687 teramer interface [polypeptide binding]; other site 362663011688 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 362663011689 active site 362663011690 FMN binding site [chemical binding]; other site 362663011691 catalytic residues [active] 362663011692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663011693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663011694 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663011695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663011696 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663011697 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 362663011698 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663011699 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 362663011700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663011701 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663011702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663011703 Transposase; Region: DEDD_Tnp_IS110; pfam01548 362663011704 putative transposase OrfB; Reviewed; Region: PHA02517 362663011705 HTH-like domain; Region: HTH_21; pfam13276 362663011706 Integrase core domain; Region: rve; pfam00665 362663011707 Integrase core domain; Region: rve_3; pfam13683 362663011708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663011709 Transposase; Region: HTH_Tnp_1; pfam01527 362663011710 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663011711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011712 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663011713 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663011714 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 362663011715 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663011716 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 362663011717 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 362663011718 PapC N-terminal domain; Region: PapC_N; pfam13954 362663011719 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663011720 PapC C-terminal domain; Region: PapC_C; pfam13953 362663011721 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 362663011722 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663011723 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663011724 Fimbrial protein; Region: Fimbrial; pfam00419 362663011725 Transposase; Region: DEDD_Tnp_IS110; pfam01548 362663011726 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663011727 Homeodomain-like domain; Region: HTH_23; cl17451 362663011728 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 362663011729 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 362663011730 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 362663011731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 362663011732 ABC-ATPase subunit interface; other site 362663011733 dimer interface [polypeptide binding]; other site 362663011734 putative PBP binding regions; other site 362663011735 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 362663011736 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 362663011737 metal binding site [ion binding]; metal-binding site 362663011738 RTX toxin acyltransferase family; Region: HlyC; pfam02794 362663011739 RTX N-terminal domain; Region: RTX; pfam02382 362663011740 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 362663011741 RTX C-terminal domain; Region: RTX_C; pfam08339 362663011742 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 362663011743 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 362663011744 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663011745 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 362663011746 Walker A/P-loop; other site 362663011747 ATP binding site [chemical binding]; other site 362663011748 Q-loop/lid; other site 362663011749 ABC transporter signature motif; other site 362663011750 Walker B; other site 362663011751 D-loop; other site 362663011752 H-loop/switch region; other site 362663011753 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 362663011754 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663011755 Urea transporter; Region: UT; cl01829 362663011756 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 362663011757 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 362663011758 Active Sites [active] 362663011759 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 362663011760 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 362663011761 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 362663011762 ParB-like nuclease domain; Region: ParBc; cl02129 362663011763 Integrase core domain; Region: rve_3; cl15866 362663011764 HTH-like domain; Region: HTH_21; pfam13276 362663011765 Integrase core domain; Region: rve; pfam00665 362663011766 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663011767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011768 Integrase core domain; Region: rve; pfam00665 362663011769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 362663011770 Integrase core domain; Region: rve_3; pfam13683 362663011771 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 362663011772 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 362663011773 putative active site [active] 362663011774 putative NTP binding site [chemical binding]; other site 362663011775 putative nucleic acid binding site [nucleotide binding]; other site 362663011776 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 362663011777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 362663011778 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 362663011779 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 362663011780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663011781 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663011782 DNA-binding interface [nucleotide binding]; DNA binding site 362663011783 Integrase core domain; Region: rve; pfam00665 362663011784 transposase/IS protein; Provisional; Region: PRK09183 362663011785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663011786 Walker A motif; other site 362663011787 ATP binding site [chemical binding]; other site 362663011788 Walker B motif; other site 362663011789 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 362663011790 homodimer interface [polypeptide binding]; other site 362663011791 putative GKAP docking site [polypeptide binding]; other site 362663011792 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 362663011793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 362663011794 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 362663011795 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 362663011796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 362663011797 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 362663011798 Transposase; Region: HTH_Tnp_1; pfam01527 362663011799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663011800 Transposase; Region: HTH_Tnp_1; pfam01527 362663011801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663011802 Predicted GTPase [General function prediction only]; Region: COG3596 362663011803 YfjP GTPase; Region: YfjP; cd11383 362663011804 G1 box; other site 362663011805 GTP/Mg2+ binding site [chemical binding]; other site 362663011806 Switch I region; other site 362663011807 G2 box; other site 362663011808 Switch II region; other site 362663011809 G3 box; other site 362663011810 G4 box; other site 362663011811 G5 box; other site 362663011812 HTH domain; Region: HTH_11; cl17392 362663011813 WYL domain; Region: WYL; pfam13280 362663011814 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 362663011815 Domain of unknown function (DUF932); Region: DUF932; pfam06067 362663011816 Antirestriction protein; Region: Antirestrict; pfam03230 362663011817 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 362663011818 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663011819 MPN+ (JAMM) motif; other site 362663011820 Zinc-binding site [ion binding]; other site 362663011821 Protein of unknown function (DUF987); Region: DUF987; pfam06174 362663011822 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 362663011823 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 362663011824 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 362663011825 Methyltransferase domain; Region: Methyltransf_27; pfam13708 362663011826 Virulence protein [General function prediction only]; Region: COG3943 362663011827 EamA-like transporter family; Region: EamA; pfam00892 362663011828 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 362663011829 EamA-like transporter family; Region: EamA; pfam00892 362663011830 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 362663011831 lipoprotein, YaeC family; Region: TIGR00363 362663011832 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 362663011833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011834 putative substrate translocation pore; other site 362663011835 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 362663011836 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362663011837 cryptic adenine deaminase; Provisional; Region: PRK10027 362663011838 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 362663011839 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 362663011840 active site 362663011841 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 362663011842 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 362663011843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011844 putative substrate translocation pore; other site 362663011845 regulatory protein UhpC; Provisional; Region: PRK11663 362663011846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011847 putative substrate translocation pore; other site 362663011848 sensory histidine kinase UhpB; Provisional; Region: PRK11644 362663011849 MASE1; Region: MASE1; pfam05231 362663011850 Histidine kinase; Region: HisKA_3; pfam07730 362663011851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663011852 ATP binding site [chemical binding]; other site 362663011853 Mg2+ binding site [ion binding]; other site 362663011854 G-X-G motif; other site 362663011855 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 362663011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663011857 active site 362663011858 phosphorylation site [posttranslational modification] 362663011859 intermolecular recognition site; other site 362663011860 dimerization interface [polypeptide binding]; other site 362663011861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663011862 DNA binding residues [nucleotide binding] 362663011863 dimerization interface [polypeptide binding]; other site 362663011864 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 362663011865 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 362663011866 putative valine binding site [chemical binding]; other site 362663011867 dimer interface [polypeptide binding]; other site 362663011868 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 362663011869 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362663011870 PYR/PP interface [polypeptide binding]; other site 362663011871 dimer interface [polypeptide binding]; other site 362663011872 TPP binding site [chemical binding]; other site 362663011873 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663011874 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 362663011875 TPP-binding site [chemical binding]; other site 362663011876 dimer interface [polypeptide binding]; other site 362663011877 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 362663011878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011879 putative substrate translocation pore; other site 362663011880 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 362663011881 Domain of unknown function (DUF202); Region: DUF202; pfam02656 362663011882 Predicted membrane protein [Function unknown]; Region: COG2149 362663011883 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 362663011884 Sulfatase; Region: Sulfatase; pfam00884 362663011885 putative transporter; Provisional; Region: PRK10484 362663011886 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 362663011887 Na binding site [ion binding]; other site 362663011888 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362663011889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663011890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663011891 putative transporter; Validated; Region: PRK03818 362663011892 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 362663011893 TrkA-C domain; Region: TrkA_C; pfam02080 362663011894 TrkA-C domain; Region: TrkA_C; pfam02080 362663011895 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 362663011896 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 362663011897 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 362663011898 putative dimer interface [polypeptide binding]; other site 362663011899 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 362663011900 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 362663011901 putative dimer interface [polypeptide binding]; other site 362663011902 hypothetical protein; Provisional; Region: PRK11616 362663011903 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 362663011904 putative oxidoreductase; Provisional; Region: PRK11445 362663011905 hypothetical protein; Provisional; Region: PRK07236 362663011906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011907 D-galactonate transporter; Region: 2A0114; TIGR00893 362663011908 putative substrate translocation pore; other site 362663011909 galactonate dehydratase; Provisional; Region: PRK14017 362663011910 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 362663011911 putative active site pocket [active] 362663011912 putative metal binding site [ion binding]; other site 362663011913 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 362663011914 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 362663011915 active site 362663011916 intersubunit interface [polypeptide binding]; other site 362663011917 catalytic residue [active] 362663011918 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 362663011919 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 362663011920 Transcriptional regulators [Transcription]; Region: FadR; COG2186 362663011921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663011922 DNA-binding site [nucleotide binding]; DNA binding site 362663011923 FCD domain; Region: FCD; pfam07729 362663011924 hypothetical protein; Provisional; Region: PRK10215 362663011925 sugar phosphate phosphatase; Provisional; Region: PRK10513 362663011926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663011927 active site 362663011928 motif I; other site 362663011929 motif II; other site 362663011930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663011931 hypothetical protein; Provisional; Region: PRK11426 362663011932 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 362663011933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663011934 Mg2+ binding site [ion binding]; other site 362663011935 G-X-G motif; other site 362663011936 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 362663011937 anchoring element; other site 362663011938 dimer interface [polypeptide binding]; other site 362663011939 ATP binding site [chemical binding]; other site 362663011940 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 362663011941 active site 362663011942 putative metal-binding site [ion binding]; other site 362663011943 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 362663011944 recF protein; Region: recf; TIGR00611 362663011945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663011946 Walker A/P-loop; other site 362663011947 ATP binding site [chemical binding]; other site 362663011948 Q-loop/lid; other site 362663011949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663011950 ABC transporter signature motif; other site 362663011951 Walker B; other site 362663011952 D-loop; other site 362663011953 H-loop/switch region; other site 362663011954 DNA polymerase III subunit beta; Validated; Region: PRK05643 362663011955 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 362663011956 putative DNA binding surface [nucleotide binding]; other site 362663011957 dimer interface [polypeptide binding]; other site 362663011958 beta-clamp/clamp loader binding surface; other site 362663011959 beta-clamp/translesion DNA polymerase binding surface; other site 362663011960 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 362663011961 DnaA N-terminal domain; Region: DnaA_N; pfam11638 362663011962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663011963 Walker A motif; other site 362663011964 ATP binding site [chemical binding]; other site 362663011965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 362663011966 Walker B motif; other site 362663011967 arginine finger; other site 362663011968 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 362663011969 DnaA box-binding interface [nucleotide binding]; other site 362663011970 ribonuclease P; Reviewed; Region: rnpA; PRK01732 362663011971 membrane protein insertase; Provisional; Region: PRK01318 362663011972 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 362663011973 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 362663011974 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 362663011975 trmE is a tRNA modification GTPase; Region: trmE; cd04164 362663011976 G1 box; other site 362663011977 GTP/Mg2+ binding site [chemical binding]; other site 362663011978 Switch I region; other site 362663011979 G2 box; other site 362663011980 Switch II region; other site 362663011981 G3 box; other site 362663011982 G4 box; other site 362663011983 G5 box; other site 362663011984 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 362663011985 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 362663011986 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 362663011987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663011988 catalytic residue [active] 362663011989 tryptophan permease TnaB; Provisional; Region: PRK09664 362663011990 aromatic amino acid transport protein; Region: araaP; TIGR00837 362663011991 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 362663011992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663011993 putative substrate translocation pore; other site 362663011994 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 362663011995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663011996 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 362663011997 substrate binding pocket [chemical binding]; other site 362663011998 dimerization interface [polypeptide binding]; other site 362663011999 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 362663012000 Predicted flavoprotein [General function prediction only]; Region: COG0431 362663012001 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 362663012002 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362663012003 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 362663012004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663012005 active site 362663012006 motif I; other site 362663012007 motif II; other site 362663012008 putative inner membrane protein; Provisional; Region: PRK09823 362663012009 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 362663012010 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 362663012011 active site 362663012012 trimer interface [polypeptide binding]; other site 362663012013 allosteric site; other site 362663012014 active site lid [active] 362663012015 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 362663012016 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 362663012017 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 362663012018 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 362663012019 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 362663012020 trimer interface; other site 362663012021 sugar binding site [chemical binding]; other site 362663012022 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 362663012023 beta-galactosidase; Region: BGL; TIGR03356 362663012024 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 362663012025 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663012026 active site turn [active] 362663012027 phosphorylation site [posttranslational modification] 362663012028 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663012029 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 362663012030 HPr interaction site; other site 362663012031 glycerol kinase (GK) interaction site [polypeptide binding]; other site 362663012032 active site 362663012033 phosphorylation site [posttranslational modification] 362663012034 transcriptional antiterminator BglG; Provisional; Region: PRK09772 362663012035 CAT RNA binding domain; Region: CAT_RBD; pfam03123 362663012036 PRD domain; Region: PRD; pfam00874 362663012037 PRD domain; Region: PRD; pfam00874 362663012038 transcriptional regulator PhoU; Provisional; Region: PRK11115 362663012039 PhoU domain; Region: PhoU; pfam01895 362663012040 PhoU domain; Region: PhoU; pfam01895 362663012041 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 362663012042 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 362663012043 Walker A/P-loop; other site 362663012044 ATP binding site [chemical binding]; other site 362663012045 Q-loop/lid; other site 362663012046 ABC transporter signature motif; other site 362663012047 Walker B; other site 362663012048 D-loop; other site 362663012049 H-loop/switch region; other site 362663012050 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 362663012051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663012052 dimer interface [polypeptide binding]; other site 362663012053 conserved gate region; other site 362663012054 putative PBP binding loops; other site 362663012055 ABC-ATPase subunit interface; other site 362663012056 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 362663012057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663012058 dimer interface [polypeptide binding]; other site 362663012059 conserved gate region; other site 362663012060 putative PBP binding loops; other site 362663012061 ABC-ATPase subunit interface; other site 362663012062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663012063 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 362663012064 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 362663012065 glutaminase active site [active] 362663012066 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 362663012067 dimer interface [polypeptide binding]; other site 362663012068 active site 362663012069 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 362663012070 dimer interface [polypeptide binding]; other site 362663012071 active site 362663012072 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 362663012073 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 362663012074 Substrate binding site; other site 362663012075 Mg++ binding site; other site 362663012076 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 362663012077 active site 362663012078 substrate binding site [chemical binding]; other site 362663012079 CoA binding site [chemical binding]; other site 362663012080 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 362663012081 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 362663012082 gamma subunit interface [polypeptide binding]; other site 362663012083 epsilon subunit interface [polypeptide binding]; other site 362663012084 LBP interface [polypeptide binding]; other site 362663012085 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 362663012086 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 362663012087 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 362663012088 alpha subunit interaction interface [polypeptide binding]; other site 362663012089 Walker A motif; other site 362663012090 ATP binding site [chemical binding]; other site 362663012091 Walker B motif; other site 362663012092 inhibitor binding site; inhibition site 362663012093 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 362663012094 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 362663012095 core domain interface [polypeptide binding]; other site 362663012096 delta subunit interface [polypeptide binding]; other site 362663012097 epsilon subunit interface [polypeptide binding]; other site 362663012098 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 362663012099 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 362663012100 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 362663012101 beta subunit interaction interface [polypeptide binding]; other site 362663012102 Walker A motif; other site 362663012103 ATP binding site [chemical binding]; other site 362663012104 Walker B motif; other site 362663012105 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 362663012106 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 362663012107 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 362663012108 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 362663012109 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 362663012110 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 362663012111 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 362663012112 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 362663012113 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 362663012114 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 362663012115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663012116 S-adenosylmethionine binding site [chemical binding]; other site 362663012117 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 362663012118 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 362663012119 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 362663012120 FMN-binding protein MioC; Provisional; Region: PRK09004 362663012121 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 362663012122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663012123 putative DNA binding site [nucleotide binding]; other site 362663012124 putative Zn2+ binding site [ion binding]; other site 362663012125 AsnC family; Region: AsnC_trans_reg; pfam01037 362663012126 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 362663012127 dimer interface [polypeptide binding]; other site 362663012128 active site 362663012129 hypothetical protein; Provisional; Region: yieM; PRK10997 362663012130 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 362663012131 metal ion-dependent adhesion site (MIDAS); other site 362663012132 regulatory ATPase RavA; Provisional; Region: PRK13531 362663012133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663012134 Walker A motif; other site 362663012135 ATP binding site [chemical binding]; other site 362663012136 Walker B motif; other site 362663012137 arginine finger; other site 362663012138 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 362663012139 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 362663012140 potassium uptake protein; Region: kup; TIGR00794 362663012141 D-ribose pyranase; Provisional; Region: PRK11797 362663012142 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 362663012143 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663012144 Walker A/P-loop; other site 362663012145 ATP binding site [chemical binding]; other site 362663012146 Q-loop/lid; other site 362663012147 ABC transporter signature motif; other site 362663012148 Walker B; other site 362663012149 D-loop; other site 362663012150 H-loop/switch region; other site 362663012151 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663012152 ribose transport system permease RbsC nonfunction due to the frame shift 362663012153 ribose transport system permease RbsC nonfunction due to the frame shift 362663012154 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 362663012155 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 362663012156 ligand binding site [chemical binding]; other site 362663012157 dimerization interface [polypeptide binding]; other site 362663012158 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 362663012159 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663012160 substrate binding site [chemical binding]; other site 362663012161 dimer interface [polypeptide binding]; other site 362663012162 ATP binding site [chemical binding]; other site 362663012163 transcriptional repressor RbsR; Provisional; Region: PRK10423 362663012164 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663012165 DNA binding site [nucleotide binding] 362663012166 domain linker motif; other site 362663012167 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 362663012168 dimerization interface [polypeptide binding]; other site 362663012169 ligand binding site [chemical binding]; other site 362663012170 putative transporter; Provisional; Region: PRK10504 362663012171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012172 putative substrate translocation pore; other site 362663012173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012174 Transcriptional regulators [Transcription]; Region: FadR; COG2186 362663012175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663012176 DNA-binding site [nucleotide binding]; DNA binding site 362663012177 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663012178 transcriptional regulator HdfR; Provisional; Region: PRK03601 362663012179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663012180 LysR substrate binding domain; Region: LysR_substrate; pfam03466 362663012181 dimerization interface [polypeptide binding]; other site 362663012182 hypothetical protein; Provisional; Region: PRK11027 362663012183 putative ATP-dependent protease; Provisional; Region: PRK09862 362663012184 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 362663012185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663012186 Walker A motif; other site 362663012187 ATP binding site [chemical binding]; other site 362663012188 Walker B motif; other site 362663012189 arginine finger; other site 362663012190 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 362663012191 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 362663012192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 362663012193 PYR/PP interface [polypeptide binding]; other site 362663012194 dimer interface [polypeptide binding]; other site 362663012195 TPP binding site [chemical binding]; other site 362663012196 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 362663012197 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 362663012198 TPP-binding site [chemical binding]; other site 362663012199 dimer interface [polypeptide binding]; other site 362663012200 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 362663012201 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 362663012202 homodimer interface [polypeptide binding]; other site 362663012203 substrate-cofactor binding pocket; other site 362663012204 catalytic residue [active] 362663012205 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 362663012206 threonine dehydratase; Reviewed; Region: PRK09224 362663012207 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 362663012208 tetramer interface [polypeptide binding]; other site 362663012209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663012210 catalytic residue [active] 362663012211 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 362663012212 putative Ile/Val binding site [chemical binding]; other site 362663012213 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 362663012214 putative Ile/Val binding site [chemical binding]; other site 362663012215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663012216 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 362663012217 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 362663012218 putative dimerization interface [polypeptide binding]; other site 362663012219 ketol-acid reductoisomerase; Validated; Region: PRK05225 362663012220 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 362663012221 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 362663012222 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 362663012223 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 362663012224 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 362663012225 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 362663012226 Part of AAA domain; Region: AAA_19; pfam13245 362663012227 Family description; Region: UvrD_C_2; pfam13538 362663012228 guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase nonfunction due to the frame shift 362663012229 guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase nonfunction due to the frame shift 362663012230 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 362663012231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 362663012232 ATP binding site [chemical binding]; other site 362663012233 Mg++ binding site [ion binding]; other site 362663012234 motif III; other site 362663012235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663012236 nucleotide binding region [chemical binding]; other site 362663012237 ATP-binding site [chemical binding]; other site 362663012238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 362663012239 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 362663012240 catalytic residues [active] 362663012241 transcription termination factor Rho; Provisional; Region: rho; PRK09376 362663012242 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 362663012243 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 362663012244 RNA binding site [nucleotide binding]; other site 362663012245 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 362663012246 multimer interface [polypeptide binding]; other site 362663012247 Walker A motif; other site 362663012248 ATP binding site [chemical binding]; other site 362663012249 Walker B motif; other site 362663012250 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 362663012251 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 362663012252 Mg++ binding site [ion binding]; other site 362663012253 putative catalytic motif [active] 362663012254 substrate binding site [chemical binding]; other site 362663012255 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 362663012256 Chain length determinant protein; Region: Wzz; pfam02706 362663012257 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 362663012258 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 362663012259 active site 362663012260 homodimer interface [polypeptide binding]; other site 362663012261 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 362663012262 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 362663012263 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 362663012264 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 362663012265 NAD binding site [chemical binding]; other site 362663012266 substrate binding site [chemical binding]; other site 362663012267 homodimer interface [polypeptide binding]; other site 362663012268 active site 362663012269 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 362663012270 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 362663012271 substrate binding site; other site 362663012272 tetramer interface; other site 362663012273 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 362663012274 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 362663012275 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 362663012276 inhibitor-cofactor binding pocket; inhibition site 362663012277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663012278 catalytic residue [active] 362663012279 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 362663012280 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 362663012281 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 362663012282 putative common antigen polymerase; Provisional; Region: PRK02975 362663012283 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 362663012284 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 362663012285 putative transport protein YifK; Provisional; Region: PRK10746 362663012286 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 362663012287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663012288 FeS/SAM binding site; other site 362663012289 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 362663012290 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 362663012291 Sulfatase; Region: Sulfatase; pfam00884 362663012292 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 362663012293 HemY protein N-terminus; Region: HemY_N; pfam07219 362663012294 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 362663012295 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 362663012296 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 362663012297 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 362663012298 active site 362663012299 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 362663012300 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 362663012301 domain interfaces; other site 362663012302 active site 362663012303 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 362663012304 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 362663012305 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 362663012306 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 362663012307 putative iron binding site [ion binding]; other site 362663012308 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 362663012309 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 362663012310 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 362663012311 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 362663012312 hypothetical protein; Provisional; Region: PRK10963 362663012313 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 362663012314 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 362663012315 active site 362663012316 DNA binding site [nucleotide binding] 362663012317 Int/Topo IB signature motif; other site 362663012318 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 362663012319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663012320 motif II; other site 362663012321 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 362663012322 Part of AAA domain; Region: AAA_19; pfam13245 362663012323 Family description; Region: UvrD_C_2; pfam13538 362663012324 Uncharacterized conserved protein [Function unknown]; Region: COG1912 362663012325 Predicted periplasmic protein [Function unknown]; Region: COG3698 362663012326 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 362663012327 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 362663012328 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 362663012329 Cl binding site [ion binding]; other site 362663012330 oligomer interface [polypeptide binding]; other site 362663012331 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 362663012332 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 362663012333 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 362663012334 EamA-like transporter family; Region: EamA; cl17759 362663012335 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 362663012336 CoenzymeA binding site [chemical binding]; other site 362663012337 subunit interaction site [polypeptide binding]; other site 362663012338 PHB binding site; other site 362663012339 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 362663012340 dimerization interface [polypeptide binding]; other site 362663012341 substrate binding site [chemical binding]; other site 362663012342 active site 362663012343 calcium binding site [ion binding]; other site 362663012344 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 362663012345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663012346 ATP binding site [chemical binding]; other site 362663012347 putative Mg++ binding site [ion binding]; other site 362663012348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 362663012349 nucleotide binding region [chemical binding]; other site 362663012350 ATP-binding site [chemical binding]; other site 362663012351 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 362663012352 Helicase and RNase D C-terminal; Region: HRDC; smart00341 362663012353 threonine efflux system; Provisional; Region: PRK10229 362663012354 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 362663012355 lysophospholipase L2; Provisional; Region: PRK10749 362663012356 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 362663012357 putative hydrolase; Provisional; Region: PRK10976 362663012358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663012359 active site 362663012360 motif I; other site 362663012361 motif II; other site 362663012362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663012363 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 362663012364 EamA-like transporter family; Region: EamA; pfam00892 362663012365 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 362663012366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663012367 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 362663012368 putative dimerization interface [polypeptide binding]; other site 362663012369 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 362663012370 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 362663012371 THF binding site; other site 362663012372 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 362663012373 substrate binding site [chemical binding]; other site 362663012374 THF binding site; other site 362663012375 zinc-binding site [ion binding]; other site 362663012376 Protein of unknown function (DUF796); Region: DUF796; cl01226 362663012377 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 362663012378 tetramer interface [polypeptide binding]; other site 362663012379 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 362663012380 active site 362663012381 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 362663012382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663012383 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663012384 active site turn [active] 362663012385 phosphorylation site [posttranslational modification] 362663012386 transketolase; Reviewed; Region: PRK12753 362663012387 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 362663012388 TPP-binding site [chemical binding]; other site 362663012389 dimer interface [polypeptide binding]; other site 362663012390 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 362663012391 PYR/PP interface [polypeptide binding]; other site 362663012392 dimer interface [polypeptide binding]; other site 362663012393 TPP binding site [chemical binding]; other site 362663012394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 362663012395 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362663012396 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 362663012397 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362663012398 putative active site [active] 362663012399 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 362663012400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663012401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663012402 dimerization interface [polypeptide binding]; other site 362663012403 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 362663012404 Na binding site [ion binding]; other site 362663012405 allophanate hydrolase; Provisional; Region: PRK08186 362663012406 carbamate kinase; Reviewed; Region: PRK12686 362663012407 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 362663012408 putative substrate binding site [chemical binding]; other site 362663012409 nucleotide binding site [chemical binding]; other site 362663012410 nucleotide binding site [chemical binding]; other site 362663012411 homodimer interface [polypeptide binding]; other site 362663012412 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 362663012413 CoA binding domain; Region: CoA_binding; pfam02629 362663012414 CoA-ligase; Region: Ligase_CoA; pfam00549 362663012415 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 362663012416 Isochorismatase family; Region: Isochorismatase; pfam00857 362663012417 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 362663012418 catalytic triad [active] 362663012419 conserved cis-peptide bond; other site 362663012420 Dienelactone hydrolase family; Region: DLH; pfam01738 362663012421 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 362663012422 uridine phosphorylase; Provisional; Region: PRK11178 362663012423 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 362663012424 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 362663012425 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 362663012426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 362663012427 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 362663012428 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 362663012429 active site 362663012430 intersubunit interface [polypeptide binding]; other site 362663012431 catalytic residue [active] 362663012432 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 362663012433 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 362663012434 Transcriptional regulator [Transcription]; Region: IclR; COG1414 362663012435 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 362663012436 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663012437 DNA recombination protein RmuC; Provisional; Region: PRK10361 362663012438 RmuC family; Region: RmuC; pfam02646 362663012439 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 362663012440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663012441 S-adenosylmethionine binding site [chemical binding]; other site 362663012442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 362663012443 SCP-2 sterol transfer family; Region: SCP2; pfam02036 362663012444 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 362663012445 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 362663012446 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 362663012447 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 362663012448 sec-independent translocase; Provisional; Region: PRK01770 362663012449 sec-independent translocase; Provisional; Region: tatB; PRK00404 362663012450 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 362663012451 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 362663012452 active site 362663012453 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 362663012454 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 362663012455 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 362663012456 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 362663012457 FMN reductase; Validated; Region: fre; PRK08051 362663012458 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 362663012459 FAD binding pocket [chemical binding]; other site 362663012460 FAD binding motif [chemical binding]; other site 362663012461 phosphate binding motif [ion binding]; other site 362663012462 beta-alpha-beta structure motif; other site 362663012463 NAD binding pocket [chemical binding]; other site 362663012464 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 362663012465 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 362663012466 dimer interface [polypeptide binding]; other site 362663012467 active site 362663012468 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 362663012469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362663012470 substrate binding site [chemical binding]; other site 362663012471 oxyanion hole (OAH) forming residues; other site 362663012472 trimer interface [polypeptide binding]; other site 362663012473 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 362663012474 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 362663012475 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 362663012476 proline dipeptidase; Provisional; Region: PRK13607 362663012477 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 362663012478 active site 362663012479 hypothetical protein; Provisional; Region: PRK11568 362663012480 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 362663012481 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 362663012482 potassium transporter; Provisional; Region: PRK10750 362663012483 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 362663012484 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 362663012485 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 362663012486 Walker A motif; other site 362663012487 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 362663012488 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 362663012489 GTP binding site; other site 362663012490 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 362663012491 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 362663012492 serine/threonine protein kinase; Provisional; Region: PRK11768 362663012493 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 362663012494 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 362663012495 catalytic residues [active] 362663012496 hinge region; other site 362663012497 alpha helical domain; other site 362663012498 hypothetical protein; Provisional; Region: PRK11367 362663012499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 362663012500 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 362663012501 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 362663012502 putative acyl-acceptor binding pocket; other site 362663012503 DNA polymerase I; Provisional; Region: PRK05755 362663012504 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 362663012505 active site 362663012506 metal binding site 1 [ion binding]; metal-binding site 362663012507 putative 5' ssDNA interaction site; other site 362663012508 metal binding site 3; metal-binding site 362663012509 metal binding site 2 [ion binding]; metal-binding site 362663012510 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 362663012511 putative DNA binding site [nucleotide binding]; other site 362663012512 putative metal binding site [ion binding]; other site 362663012513 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 362663012514 active site 362663012515 catalytic site [active] 362663012516 substrate binding site [chemical binding]; other site 362663012517 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 362663012518 active site 362663012519 DNA binding site [nucleotide binding] 362663012520 catalytic site [active] 362663012521 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 362663012522 GTP/Mg2+ binding site [chemical binding]; other site 362663012523 G1 box; other site 362663012524 Switch I region; other site 362663012525 G2 box; other site 362663012526 G3 box; other site 362663012527 Switch II region; other site 362663012528 G4 box; other site 362663012529 G5 box; other site 362663012530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 362663012531 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 362663012532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663012533 FeS/SAM binding site; other site 362663012534 HemN C-terminal domain; Region: HemN_C; pfam06969 362663012535 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 362663012536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663012537 active site 362663012538 phosphorylation site [posttranslational modification] 362663012539 intermolecular recognition site; other site 362663012540 dimerization interface [polypeptide binding]; other site 362663012541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663012542 Walker A motif; other site 362663012543 ATP binding site [chemical binding]; other site 362663012544 Walker B motif; other site 362663012545 arginine finger; other site 362663012546 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663012547 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 362663012548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 362663012549 putative active site [active] 362663012550 heme pocket [chemical binding]; other site 362663012551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663012552 dimer interface [polypeptide binding]; other site 362663012553 phosphorylation site [posttranslational modification] 362663012554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663012555 ATP binding site [chemical binding]; other site 362663012556 Mg2+ binding site [ion binding]; other site 362663012557 G-X-G motif; other site 362663012558 glutamine synthetase; Provisional; Region: glnA; PRK09469 362663012559 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 362663012560 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 362663012561 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 362663012562 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 362663012563 G1 box; other site 362663012564 putative GEF interaction site [polypeptide binding]; other site 362663012565 GTP/Mg2+ binding site [chemical binding]; other site 362663012566 Switch I region; other site 362663012567 G2 box; other site 362663012568 G3 box; other site 362663012569 Switch II region; other site 362663012570 G4 box; other site 362663012571 G5 box; other site 362663012572 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 362663012573 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 362663012574 transcriptional regulator protein; Region: phnR; TIGR03337 362663012575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663012576 DNA-binding site [nucleotide binding]; DNA binding site 362663012577 UTRA domain; Region: UTRA; pfam07702 362663012578 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 362663012579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012580 putative substrate translocation pore; other site 362663012581 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 362663012582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 362663012583 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 362663012584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663012585 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 362663012586 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 362663012587 substrate binding site [chemical binding]; other site 362663012588 ATP binding site [chemical binding]; other site 362663012589 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 362663012590 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 362663012591 Class I aldolases; Region: Aldolase_Class_I; cl17187 362663012592 catalytic residue [active] 362663012593 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 362663012594 putative oxidoreductase; Provisional; Region: PRK10083 362663012595 NAD(P) binding site [chemical binding]; other site 362663012596 benzoate transport; Region: 2A0115; TIGR00895 362663012597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012599 shikimate transporter; Provisional; Region: PRK09952 362663012600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012601 putative substrate translocation pore; other site 362663012602 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 362663012603 active site 362663012604 catalytic residues [active] 362663012605 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 362663012606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663012607 motif II; other site 362663012608 hypothetical protein; Reviewed; Region: PRK01637 362663012609 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 362663012610 putative active site [active] 362663012611 dimerization interface [polypeptide binding]; other site 362663012612 putative tRNAtyr binding site [nucleotide binding]; other site 362663012613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663012614 Coenzyme A binding pocket [chemical binding]; other site 362663012615 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 362663012616 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 362663012617 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 362663012618 substrate binding pocket [chemical binding]; other site 362663012619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663012620 non-specific DNA binding site [nucleotide binding]; other site 362663012621 salt bridge; other site 362663012622 sequence-specific DNA binding site [nucleotide binding]; other site 362663012623 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 362663012624 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 362663012625 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 362663012626 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 362663012627 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 362663012628 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 362663012629 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 362663012630 formate dehydrogenase-O, major subunit nonfunction due to the frame shift 362663012631 formate dehydrogenase-O, major subunit nonfunction due to the frame shift 362663012632 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 362663012633 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 362663012634 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 362663012635 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 362663012636 intersubunit interface [polypeptide binding]; other site 362663012637 active site 362663012638 Zn2+ binding site [ion binding]; other site 362663012639 L-rhamnose isomerase; Provisional; Region: PRK01076 362663012640 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 362663012641 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 362663012642 N- and C-terminal domain interface [polypeptide binding]; other site 362663012643 active site 362663012644 putative catalytic site [active] 362663012645 metal binding site [ion binding]; metal-binding site 362663012646 ATP binding site [chemical binding]; other site 362663012647 rhamnulokinase; Provisional; Region: rhaB; PRK10640 362663012648 carbohydrate binding site [chemical binding]; other site 362663012649 transcriptional activator RhaS; Provisional; Region: PRK13503 362663012650 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362663012651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663012652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663012653 transcriptional activator RhaR; Provisional; Region: PRK13500 362663012654 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 362663012655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663012656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663012657 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 362663012658 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 362663012659 superoxide dismutase; Provisional; Region: PRK10925 362663012660 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 362663012661 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 362663012662 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 362663012663 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 362663012664 MOSC domain; Region: MOSC; pfam03473 362663012665 3-alpha domain; Region: 3-alpha; pfam03475 362663012666 two-component sensor protein; Provisional; Region: cpxA; PRK09470 362663012667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663012668 dimerization interface [polypeptide binding]; other site 362663012669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663012670 dimer interface [polypeptide binding]; other site 362663012671 phosphorylation site [posttranslational modification] 362663012672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663012673 ATP binding site [chemical binding]; other site 362663012674 Mg2+ binding site [ion binding]; other site 362663012675 G-X-G motif; other site 362663012676 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 362663012677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663012678 active site 362663012679 intermolecular recognition site; other site 362663012680 dimerization interface [polypeptide binding]; other site 362663012681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663012682 DNA binding site [nucleotide binding] 362663012683 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 362663012684 dimer interface [polypeptide binding]; other site 362663012685 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 362663012686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 362663012687 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 362663012688 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 362663012689 active site 362663012690 ADP/pyrophosphate binding site [chemical binding]; other site 362663012691 dimerization interface [polypeptide binding]; other site 362663012692 allosteric effector site; other site 362663012693 fructose-1,6-bisphosphate binding site; other site 362663012694 sulfate transporter subunit; Provisional; Region: PRK10752 362663012695 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 362663012696 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 362663012697 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 362663012698 triosephosphate isomerase; Provisional; Region: PRK14567 362663012699 substrate binding site [chemical binding]; other site 362663012700 dimer interface [polypeptide binding]; other site 362663012701 catalytic triad [active] 362663012702 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 362663012703 Predicted membrane protein [Function unknown]; Region: COG3152 362663012704 hypothetical protein; Provisional; Region: PRK09981 362663012705 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 362663012706 Ligand Binding Site [chemical binding]; other site 362663012707 ferredoxin-NADP reductase; Provisional; Region: PRK10926 362663012708 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 362663012709 FAD binding pocket [chemical binding]; other site 362663012710 FAD binding motif [chemical binding]; other site 362663012711 phosphate binding motif [ion binding]; other site 362663012712 beta-alpha-beta structure motif; other site 362663012713 NAD binding pocket [chemical binding]; other site 362663012714 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 362663012715 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 362663012716 putative active site [active] 362663012717 glycerol kinase; Provisional; Region: glpK; PRK00047 362663012718 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 362663012719 N- and C-terminal domain interface [polypeptide binding]; other site 362663012720 active site 362663012721 MgATP binding site [chemical binding]; other site 362663012722 catalytic site [active] 362663012723 metal binding site [ion binding]; metal-binding site 362663012724 glycerol binding site [chemical binding]; other site 362663012725 homotetramer interface [polypeptide binding]; other site 362663012726 homodimer interface [polypeptide binding]; other site 362663012727 FBP binding site [chemical binding]; other site 362663012728 protein IIAGlc interface [polypeptide binding]; other site 362663012729 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 362663012730 amphipathic channel; other site 362663012731 Asn-Pro-Ala signature motifs; other site 362663012732 septal ring assembly protein ZapB; Provisional; Region: PRK15422 362663012733 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 362663012734 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 362663012735 UbiA prenyltransferase family; Region: UbiA; pfam01040 362663012736 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 362663012737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663012738 Walker A motif; other site 362663012739 ATP binding site [chemical binding]; other site 362663012740 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 362663012741 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 362663012742 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 362663012743 active site 362663012744 HslU subunit interaction site [polypeptide binding]; other site 362663012745 essential cell division protein FtsN; Provisional; Region: PRK10927 362663012746 cell division protein FtsN; Provisional; Region: PRK12757 362663012747 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663012748 DNA binding site [nucleotide binding] 362663012749 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 362663012750 domain linker motif; other site 362663012751 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 362663012752 dimerization interface [polypeptide binding]; other site 362663012753 ligand binding site [chemical binding]; other site 362663012754 primosome assembly protein PriA; Validated; Region: PRK05580 362663012755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663012756 ATP binding site [chemical binding]; other site 362663012757 putative Mg++ binding site [ion binding]; other site 362663012758 helicase superfamily c-terminal domain; Region: HELICc; smart00490 362663012759 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 362663012760 hypothetical protein; Provisional; Region: PRK10030 362663012761 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 362663012762 dimerization interface [polypeptide binding]; other site 362663012763 DNA binding site [nucleotide binding] 362663012764 corepressor binding sites; other site 362663012765 cystathionine gamma-synthase; Provisional; Region: PRK08045 362663012766 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 362663012767 homodimer interface [polypeptide binding]; other site 362663012768 substrate-cofactor binding pocket; other site 362663012769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663012770 catalytic residue [active] 362663012771 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 362663012772 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 362663012773 putative catalytic residues [active] 362663012774 putative nucleotide binding site [chemical binding]; other site 362663012775 putative aspartate binding site [chemical binding]; other site 362663012776 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 362663012777 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 362663012778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 362663012779 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 362663012780 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 362663012781 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 362663012782 active site 362663012783 metal binding site [ion binding]; metal-binding site 362663012784 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 362663012785 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 362663012786 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 362663012787 active site 362663012788 metal binding site [ion binding]; metal-binding site 362663012789 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 362663012790 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 362663012791 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 362663012792 active site 362663012793 metal binding site [ion binding]; metal-binding site 362663012794 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 362663012795 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 362663012796 FAD binding site [chemical binding]; other site 362663012797 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 362663012798 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 362663012799 heme binding site [chemical binding]; other site 362663012800 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 362663012801 EamA-like transporter family; Region: EamA; pfam00892 362663012802 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 362663012803 EamA-like transporter family; Region: EamA; pfam00892 362663012804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 362663012805 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 362663012806 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 362663012807 dimer interface [polypeptide binding]; other site 362663012808 active site 362663012809 metal binding site [ion binding]; metal-binding site 362663012810 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 362663012811 active site 362663012812 intersubunit interactions; other site 362663012813 catalytic residue [active] 362663012814 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 362663012815 dimerization domain swap beta strand [polypeptide binding]; other site 362663012816 regulatory protein interface [polypeptide binding]; other site 362663012817 active site 362663012818 regulatory phosphorylation site [posttranslational modification]; other site 362663012819 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 362663012820 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 362663012821 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 362663012822 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663012823 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663012824 active site 362663012825 phosphorylation site [posttranslational modification] 362663012826 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 362663012827 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 362663012828 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362663012829 active site 362663012830 P-loop; other site 362663012831 phosphorylation site [posttranslational modification] 362663012832 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 362663012833 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 362663012834 dimer interface [polypeptide binding]; other site 362663012835 active site 362663012836 glycine loop; other site 362663012837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 362663012838 FeS/SAM binding site; other site 362663012839 pyruvate formate lyase II activase; Provisional; Region: PRK10076 362663012840 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 362663012841 active site 362663012842 P-loop; other site 362663012843 phosphorylation site [posttranslational modification] 362663012844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663012845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663012846 hypothetical protein; Provisional; Region: PRK10649 362663012847 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 362663012848 Sulfatase; Region: Sulfatase; pfam00884 362663012849 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 362663012850 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 362663012851 acetylornithine deacetylase; Provisional; Region: PRK05111 362663012852 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 362663012853 metal binding site [ion binding]; metal-binding site 362663012854 putative dimer interface [polypeptide binding]; other site 362663012855 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 362663012856 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 362663012857 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 362663012858 nucleotide binding site [chemical binding]; other site 362663012859 N-acetyl-L-glutamate binding site [chemical binding]; other site 362663012860 argininosuccinate lyase; Provisional; Region: PRK04833 362663012861 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 362663012862 active sites [active] 362663012863 tetramer interface [polypeptide binding]; other site 362663012864 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 362663012865 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 362663012866 putative active site pocket [active] 362663012867 putative metal binding site [ion binding]; other site 362663012868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012869 D-galactonate transporter; Region: 2A0114; TIGR00893 362663012870 putative substrate translocation pore; other site 362663012871 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 362663012872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663012873 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 362663012874 dimerization interface [polypeptide binding]; other site 362663012875 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 362663012876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663012877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 362663012878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 362663012879 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 362663012880 metal binding site [ion binding]; metal-binding site 362663012881 putative dimer interface [polypeptide binding]; other site 362663012882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663012883 metabolite-proton symporter; Region: 2A0106; TIGR00883 362663012884 putative substrate translocation pore; other site 362663012885 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 362663012886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663012887 hypothetical protein; Provisional; Region: PRK11056 362663012888 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 362663012889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663012890 S-adenosylmethionine binding site [chemical binding]; other site 362663012891 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 362663012892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 362663012893 N-terminal plug; other site 362663012894 ligand-binding site [chemical binding]; other site 362663012895 glutamate racemase; Provisional; Region: PRK00865 362663012896 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 362663012897 FAD binding domain; Region: FAD_binding_4; pfam01565 362663012898 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 362663012899 Biotin operon repressor [Transcription]; Region: BirA; COG1654 362663012900 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 362663012901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 362663012902 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 362663012903 pantothenate kinase; Provisional; Region: PRK05439 362663012904 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 362663012905 ATP-binding site [chemical binding]; other site 362663012906 CoA-binding site [chemical binding]; other site 362663012907 Mg2+-binding site [ion binding]; other site 362663012908 elongation factor Tu; Reviewed; Region: PRK00049 362663012909 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 362663012910 G1 box; other site 362663012911 GEF interaction site [polypeptide binding]; other site 362663012912 GTP/Mg2+ binding site [chemical binding]; other site 362663012913 Switch I region; other site 362663012914 G2 box; other site 362663012915 G3 box; other site 362663012916 Switch II region; other site 362663012917 G4 box; other site 362663012918 G5 box; other site 362663012919 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 362663012920 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 362663012921 Antibiotic Binding Site [chemical binding]; other site 362663012922 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 362663012923 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 362663012924 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 362663012925 putative homodimer interface [polypeptide binding]; other site 362663012926 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 362663012927 heterodimer interface [polypeptide binding]; other site 362663012928 homodimer interface [polypeptide binding]; other site 362663012929 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 362663012930 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 362663012931 23S rRNA interface [nucleotide binding]; other site 362663012932 L7/L12 interface [polypeptide binding]; other site 362663012933 putative thiostrepton binding site; other site 362663012934 L25 interface [polypeptide binding]; other site 362663012935 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 362663012936 mRNA/rRNA interface [nucleotide binding]; other site 362663012937 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 362663012938 23S rRNA interface [nucleotide binding]; other site 362663012939 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 362663012940 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 362663012941 core dimer interface [polypeptide binding]; other site 362663012942 peripheral dimer interface [polypeptide binding]; other site 362663012943 L10 interface [polypeptide binding]; other site 362663012944 L11 interface [polypeptide binding]; other site 362663012945 putative EF-Tu interaction site [polypeptide binding]; other site 362663012946 putative EF-G interaction site [polypeptide binding]; other site 362663012947 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 362663012948 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 362663012949 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 362663012950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 362663012951 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 362663012952 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 362663012953 RPB3 interaction site [polypeptide binding]; other site 362663012954 RPB1 interaction site [polypeptide binding]; other site 362663012955 RPB11 interaction site [polypeptide binding]; other site 362663012956 RPB10 interaction site [polypeptide binding]; other site 362663012957 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 362663012958 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 362663012959 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 362663012960 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 362663012961 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 362663012962 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 362663012963 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 362663012964 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 362663012965 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 362663012966 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 362663012967 DNA binding site [nucleotide binding] 362663012968 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 362663012969 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 362663012970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663012971 FeS/SAM binding site; other site 362663012972 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 362663012973 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 362663012974 ThiS interaction site; other site 362663012975 putative active site [active] 362663012976 tetramer interface [polypeptide binding]; other site 362663012977 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 362663012978 thiS-thiF/thiG interaction site; other site 362663012979 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 362663012980 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 362663012981 ATP binding site [chemical binding]; other site 362663012982 substrate interface [chemical binding]; other site 362663012983 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 362663012984 thiamine phosphate binding site [chemical binding]; other site 362663012985 active site 362663012986 pyrophosphate binding site [ion binding]; other site 362663012987 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 362663012988 ThiC-associated domain; Region: ThiC-associated; pfam13667 362663012989 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 362663012990 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 362663012991 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 362663012992 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 362663012993 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 362663012994 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 362663012995 putative NADH binding site [chemical binding]; other site 362663012996 putative active site [active] 362663012997 nudix motif; other site 362663012998 putative metal binding site [ion binding]; other site 362663012999 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 362663013000 substrate binding site [chemical binding]; other site 362663013001 active site 362663013002 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 362663013003 Active_site [active] 362663013004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 362663013005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 362663013006 IHF dimer interface [polypeptide binding]; other site 362663013007 IHF - DNA interface [nucleotide binding]; other site 362663013008 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 362663013009 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 362663013010 dimer interface [polypeptide binding]; other site 362663013011 sensor protein ZraS; Provisional; Region: PRK10364 362663013012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663013013 dimer interface [polypeptide binding]; other site 362663013014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663013015 ATP binding site [chemical binding]; other site 362663013016 Mg2+ binding site [ion binding]; other site 362663013017 G-X-G motif; other site 362663013018 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 362663013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663013020 active site 362663013021 phosphorylation site [posttranslational modification] 362663013022 intermolecular recognition site; other site 362663013023 dimerization interface [polypeptide binding]; other site 362663013024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663013025 Walker A motif; other site 362663013026 ATP binding site [chemical binding]; other site 362663013027 Walker B motif; other site 362663013028 arginine finger; other site 362663013029 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663013030 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 362663013031 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 362663013032 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 362663013033 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 362663013034 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 362663013035 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 362663013036 purine monophosphate binding site [chemical binding]; other site 362663013037 dimer interface [polypeptide binding]; other site 362663013038 putative catalytic residues [active] 362663013039 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 362663013040 hypothetical protein; Provisional; Region: PRK10039 362663013041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 362663013042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663013043 Coenzyme A binding pocket [chemical binding]; other site 362663013044 homoserine O-succinyltransferase; Provisional; Region: PRK05368 362663013045 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 362663013046 proposed active site lysine [active] 362663013047 conserved cys residue [active] 362663013048 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 362663013049 malate synthase A; Region: malate_syn_A; TIGR01344 362663013050 active site 362663013051 isocitrate lyase; Provisional; Region: PRK15063 362663013052 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 362663013053 tetramer interface [polypeptide binding]; other site 362663013054 active site 362663013055 Mg2+/Mn2+ binding site [ion binding]; other site 362663013056 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 362663013057 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 362663013058 transcriptional repressor IclR; Provisional; Region: PRK11569 362663013059 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 362663013060 Bacterial transcriptional regulator; Region: IclR; pfam01614 362663013061 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 362663013062 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 362663013063 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 362663013064 substrate binding pocket [chemical binding]; other site 362663013065 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 362663013066 B12 binding site [chemical binding]; other site 362663013067 cobalt ligand [ion binding]; other site 362663013068 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 362663013069 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 362663013070 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 362663013071 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 362663013072 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 362663013073 active site pocket [active] 362663013074 oxyanion hole [active] 362663013075 catalytic triad [active] 362663013076 active site nucleophile [active] 362663013077 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 362663013078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663013079 putative NAD(P) binding site [chemical binding]; other site 362663013080 catalytic Zn binding site [ion binding]; other site 362663013081 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 362663013082 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 362663013083 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 362663013084 active site 362663013085 phosphorylation site [posttranslational modification] 362663013086 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 362663013087 active pocket/dimerization site; other site 362663013088 active site 362663013089 phosphorylation site [posttranslational modification] 362663013090 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 362663013091 classical (c) SDRs; Region: SDR_c; cd05233 362663013092 NAD(P) binding site [chemical binding]; other site 362663013093 active site 362663013094 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 362663013095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 362663013096 putative DNA binding site [nucleotide binding]; other site 362663013097 putative Zn2+ binding site [ion binding]; other site 362663013098 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 362663013099 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 362663013100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 362663013101 RNA binding surface [nucleotide binding]; other site 362663013102 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 362663013103 probable active site [active] 362663013104 hypothetical protein; Provisional; Region: PRK10515 362663013105 aspartate kinase III; Validated; Region: PRK09084 362663013106 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 362663013107 nucleotide binding site [chemical binding]; other site 362663013108 substrate binding site [chemical binding]; other site 362663013109 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 362663013110 lysine allosteric regulatory site; other site 362663013111 dimer interface [polypeptide binding]; other site 362663013112 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 362663013113 dimer interface [polypeptide binding]; other site 362663013114 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 362663013115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 362663013116 active site 362663013117 dimer interface [polypeptide binding]; other site 362663013118 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 362663013119 dimer interface [polypeptide binding]; other site 362663013120 active site 362663013121 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 362663013122 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 362663013123 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 362663013124 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 362663013125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 362663013126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663013127 dimer interface [polypeptide binding]; other site 362663013128 conserved gate region; other site 362663013129 putative PBP binding loops; other site 362663013130 ABC-ATPase subunit interface; other site 362663013131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663013132 dimer interface [polypeptide binding]; other site 362663013133 conserved gate region; other site 362663013134 putative PBP binding loops; other site 362663013135 ABC-ATPase subunit interface; other site 362663013136 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 362663013137 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 362663013138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 362663013139 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 362663013140 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 362663013141 Walker A/P-loop; other site 362663013142 ATP binding site [chemical binding]; other site 362663013143 Q-loop/lid; other site 362663013144 ABC transporter signature motif; other site 362663013145 Walker B; other site 362663013146 D-loop; other site 362663013147 H-loop/switch region; other site 362663013148 TOBE domain; Region: TOBE_2; pfam08402 362663013149 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 362663013150 trimer interface; other site 362663013151 sugar binding site [chemical binding]; other site 362663013152 maltose regulon periplasmic protein; Provisional; Region: PRK10564 362663013153 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 362663013154 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 362663013155 UbiA prenyltransferase family; Region: UbiA; pfam01040 362663013156 glycerol-3-phosphate acyltransferase 362663013157 glycerol-3-phosphate acyltransferase nonfunction due to the frame shift 362663013158 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 362663013159 LexA repressor; Validated; Region: PRK00215 362663013160 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 362663013161 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 362663013162 Catalytic site [active] 362663013163 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 362663013164 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 362663013165 hypothetical protein; Provisional; Region: PRK10428 362663013166 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 362663013167 metal binding site 2 [ion binding]; metal-binding site 362663013168 putative DNA binding helix; other site 362663013169 metal binding site 1 [ion binding]; metal-binding site 362663013170 dimer interface [polypeptide binding]; other site 362663013171 structural Zn2+ binding site [ion binding]; other site 362663013172 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 362663013173 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 362663013174 FMN binding site [chemical binding]; other site 362663013175 active site 362663013176 catalytic residues [active] 362663013177 substrate binding site [chemical binding]; other site 362663013178 phage shock protein G; Reviewed; Region: pspG; PRK09459 362663013179 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 362663013180 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 362663013181 NADP binding site [chemical binding]; other site 362663013182 dimer interface [polypeptide binding]; other site 362663013183 replicative DNA helicase; Provisional; Region: PRK08006 362663013184 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 362663013185 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 362663013186 Walker A motif; other site 362663013187 ATP binding site [chemical binding]; other site 362663013188 Walker B motif; other site 362663013189 DNA binding loops [nucleotide binding] 362663013190 putative lipoprotein; Provisional; Region: PRK10533 362663013191 alanine racemase; Reviewed; Region: alr; PRK00053 362663013192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 362663013193 active site 362663013194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 362663013195 substrate binding site [chemical binding]; other site 362663013196 catalytic residues [active] 362663013197 dimer interface [polypeptide binding]; other site 362663013198 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 362663013199 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 362663013200 active site 362663013201 nucleotide binding site [chemical binding]; other site 362663013202 HIGH motif; other site 362663013203 KMSKS motif; other site 362663013204 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 362663013205 AAA domain; Region: AAA_28; pfam13521 362663013206 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 362663013207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663013208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663013209 homodimer interface [polypeptide binding]; other site 362663013210 catalytic residue [active] 362663013211 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 362663013212 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 362663013213 TPP-binding site [chemical binding]; other site 362663013214 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 362663013215 dimer interface [polypeptide binding]; other site 362663013216 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 362663013217 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 362663013218 E3 interaction surface; other site 362663013219 lipoyl attachment site [posttranslational modification]; other site 362663013220 e3 binding domain; Region: E3_binding; pfam02817 362663013221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 362663013222 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 362663013223 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 362663013224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 362663013225 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 362663013226 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 362663013227 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 362663013228 CoA-ligase; Region: Ligase_CoA; pfam00549 362663013229 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 362663013230 CoA binding domain; Region: CoA_binding; smart00881 362663013231 CoA-ligase; Region: Ligase_CoA; pfam00549 362663013232 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 362663013233 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 362663013234 transmembrane helices; other site 362663013235 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 362663013236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 362663013237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663013238 active site 362663013239 phosphorylation site [posttranslational modification] 362663013240 intermolecular recognition site; other site 362663013241 dimerization interface [polypeptide binding]; other site 362663013242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663013243 Walker A motif; other site 362663013244 ATP binding site [chemical binding]; other site 362663013245 Walker B motif; other site 362663013246 arginine finger; other site 362663013247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 362663013248 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 362663013249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663013250 dimer interface [polypeptide binding]; other site 362663013251 phosphorylation site [posttranslational modification] 362663013252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663013253 ATP binding site [chemical binding]; other site 362663013254 Mg2+ binding site [ion binding]; other site 362663013255 G-X-G motif; other site 362663013256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663013257 active site 362663013258 motif I; other site 362663013259 motif II; other site 362663013260 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 362663013261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 362663013262 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 362663013263 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 362663013264 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 362663013265 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 362663013266 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 362663013267 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 362663013268 dimer interface [polypeptide binding]; other site 362663013269 ssDNA binding site [nucleotide binding]; other site 362663013270 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362663013271 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 362663013272 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 362663013273 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 362663013274 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 362663013275 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 362663013276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663013277 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 362663013278 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 362663013279 DNA binding residues [nucleotide binding] 362663013280 dimer interface [polypeptide binding]; other site 362663013281 [2Fe-2S] cluster binding site [ion binding]; other site 362663013282 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 362663013283 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 362663013284 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 362663013285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663013286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663013287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 362663013288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663013289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 362663013290 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 362663013291 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 362663013292 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 362663013293 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 362663013294 Na binding site [ion binding]; other site 362663013295 Predicted membrane protein [Function unknown]; Region: COG3162 362663013296 acetyl-CoA synthetase; Provisional; Region: PRK00174 362663013297 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 362663013298 active site 362663013299 CoA binding site [chemical binding]; other site 362663013300 acyl-activating enzyme (AAE) consensus motif; other site 362663013301 AMP binding site [chemical binding]; other site 362663013302 acetate binding site [chemical binding]; other site 362663013303 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 362663013304 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 362663013305 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 362663013306 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 362663013307 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 362663013308 heme lyase subunit NrfE; Provisional; Region: PRK10369 362663013309 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 362663013310 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 362663013311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 362663013312 binding surface 362663013313 TPR motif; other site 362663013314 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 362663013315 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 362663013316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663013317 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663013318 Helix-turn-helix domain; Region: HTH_28; pfam13518 362663013319 HTH-like domain; Region: HTH_21; pfam13276 362663013320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 362663013321 Integrase core domain; Region: rve; pfam00665 362663013322 Integrase core domain; Region: rve_2; pfam13333 362663013323 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 362663013324 Sel1-like repeats; Region: SEL1; smart00671 362663013325 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 362663013326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663013327 Walker A/P-loop; other site 362663013328 ATP binding site [chemical binding]; other site 362663013329 Q-loop/lid; other site 362663013330 ABC transporter signature motif; other site 362663013331 Walker B; other site 362663013332 D-loop; other site 362663013333 H-loop/switch region; other site 362663013334 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 362663013335 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663013336 Walker A/P-loop; other site 362663013337 ATP binding site [chemical binding]; other site 362663013338 Q-loop/lid; other site 362663013339 ABC transporter signature motif; other site 362663013340 Walker B; other site 362663013341 D-loop; other site 362663013342 H-loop/switch region; other site 362663013343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 362663013344 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 362663013345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663013346 dimer interface [polypeptide binding]; other site 362663013347 conserved gate region; other site 362663013348 ABC-ATPase subunit interface; other site 362663013349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 362663013350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663013351 dimer interface [polypeptide binding]; other site 362663013352 conserved gate region; other site 362663013353 putative PBP binding loops; other site 362663013354 ABC-ATPase subunit interface; other site 362663013355 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 362663013356 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 362663013357 formate dehydrogenase H nonfunction due to the frame shift 362663013358 formate dehydrogenase H nonfunction due to the frame shift 362663013359 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 362663013360 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 362663013361 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 362663013362 multidrug resistance protein MdtN; Provisional; Region: PRK10476 362663013363 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663013364 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663013365 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 362663013366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 362663013367 D-allose kinase; Provisional; Region: PRK09698 362663013368 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 362663013369 nucleotide binding site [chemical binding]; other site 362663013370 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 362663013371 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 362663013372 substrate binding site [chemical binding]; other site 362663013373 hexamer interface [polypeptide binding]; other site 362663013374 metal binding site [ion binding]; metal-binding site 362663013375 D-allose transport system permease AlsC nonfunction due to the frame shift 362663013376 D-allose transport system permease AlsC nonfunction due to the frame shift 362663013377 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 362663013378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663013379 Walker A/P-loop; other site 362663013380 ATP binding site [chemical binding]; other site 362663013381 Q-loop/lid; other site 362663013382 ABC transporter signature motif; other site 362663013383 Walker B; other site 362663013384 D-loop; other site 362663013385 H-loop/switch region; other site 362663013386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663013387 D-allose transporter subunit; Provisional; Region: PRK09701 362663013388 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 362663013389 ligand binding site [chemical binding]; other site 362663013390 dimerization interface [polypeptide binding]; other site 362663013391 zinc binding site [ion binding]; other site 362663013392 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 362663013393 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 362663013394 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 362663013395 putative active site [active] 362663013396 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 362663013397 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 362663013398 putative hydrolase; Provisional; Region: PRK02113 362663013399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663013400 Coenzyme A binding pocket [chemical binding]; other site 362663013401 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 362663013402 AAA domain; Region: AAA_18; pfam13238 362663013403 active site 362663013404 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 362663013405 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 362663013406 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 362663013407 active site 362663013408 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 362663013409 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 362663013410 Walker A/P-loop; other site 362663013411 ATP binding site [chemical binding]; other site 362663013412 Q-loop/lid; other site 362663013413 ABC transporter signature motif; other site 362663013414 Walker B; other site 362663013415 D-loop; other site 362663013416 H-loop/switch region; other site 362663013417 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 362663013418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 362663013419 Walker A/P-loop; other site 362663013420 ATP binding site [chemical binding]; other site 362663013421 Q-loop/lid; other site 362663013422 ABC transporter signature motif; other site 362663013423 Walker B; other site 362663013424 D-loop; other site 362663013425 H-loop/switch region; other site 362663013426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 362663013427 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 362663013428 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 362663013429 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 362663013430 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 362663013431 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 362663013432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663013433 DNA-binding site [nucleotide binding]; DNA binding site 362663013434 UTRA domain; Region: UTRA; pfam07702 362663013435 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 362663013436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 362663013437 dimer interface [polypeptide binding]; other site 362663013438 conserved gate region; other site 362663013439 putative PBP binding loops; other site 362663013440 ABC-ATPase subunit interface; other site 362663013441 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 362663013442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 362663013443 substrate binding pocket [chemical binding]; other site 362663013444 membrane-bound complex binding site; other site 362663013445 hinge residues; other site 362663013446 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 362663013447 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 362663013448 Walker A/P-loop; other site 362663013449 ATP binding site [chemical binding]; other site 362663013450 Q-loop/lid; other site 362663013451 ABC transporter signature motif; other site 362663013452 Walker B; other site 362663013453 D-loop; other site 362663013454 H-loop/switch region; other site 362663013455 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 362663013456 dimer interface [polypeptide binding]; other site 362663013457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 362663013458 hypothetical protein; Provisional; Region: PRK10220 362663013459 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 362663013460 PhnA protein; Region: PhnA; pfam03831 362663013461 hypothetical protein; Provisional; Region: PRK09866 362663013462 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 362663013463 G1 box; other site 362663013464 GTP/Mg2+ binding site [chemical binding]; other site 362663013465 G2 box; other site 362663013466 Switch I region; other site 362663013467 G3 box; other site 362663013468 Switch II region; other site 362663013469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 362663013470 G2 box; other site 362663013471 Switch I region; other site 362663013472 G3 box; other site 362663013473 Switch II region; other site 362663013474 G4 box; other site 362663013475 G5 box; other site 362663013476 YjcZ-like protein; Region: YjcZ; pfam13990 362663013477 proline/glycine betaine transporter; Provisional; Region: PRK10642 362663013478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663013479 putative substrate translocation pore; other site 362663013480 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 362663013481 sensor protein BasS/PmrB; Provisional; Region: PRK10755 362663013482 HAMP domain; Region: HAMP; pfam00672 362663013483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663013484 dimer interface [polypeptide binding]; other site 362663013485 phosphorylation site [posttranslational modification] 362663013486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663013487 ATP binding site [chemical binding]; other site 362663013488 Mg2+ binding site [ion binding]; other site 362663013489 G-X-G motif; other site 362663013490 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 362663013491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663013492 active site 362663013493 phosphorylation site [posttranslational modification] 362663013494 intermolecular recognition site; other site 362663013495 dimerization interface [polypeptide binding]; other site 362663013496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663013497 DNA binding site [nucleotide binding] 362663013498 putative metal dependent hydrolase; Provisional; Region: PRK11598 362663013499 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 362663013500 Sulfatase; Region: Sulfatase; pfam00884 362663013501 arginine:agmatin antiporter; Provisional; Region: PRK10644 362663013502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 362663013503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663013504 arginine decarboxylase; Provisional; Region: PRK15029 362663013505 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663013506 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663013507 homodimer interface [polypeptide binding]; other site 362663013508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663013509 catalytic residue [active] 362663013510 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663013511 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 362663013512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663013513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663013514 alpha-galactosidase; Provisional; Region: PRK15076 362663013515 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 362663013516 NAD binding site [chemical binding]; other site 362663013517 sugar binding site [chemical binding]; other site 362663013518 divalent metal binding site [ion binding]; other site 362663013519 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 362663013520 dimer interface [polypeptide binding]; other site 362663013521 hypothetical protein; Provisional; Region: PRK09867 362663013522 fumarate hydratase; Provisional; Region: PRK15389 362663013523 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 362663013524 Fumarase C-terminus; Region: Fumerase_C; pfam05683 362663013525 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 362663013526 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 362663013527 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 362663013528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663013529 active site 362663013530 phosphorylation site [posttranslational modification] 362663013531 intermolecular recognition site; other site 362663013532 dimerization interface [polypeptide binding]; other site 362663013533 Transcriptional regulator; Region: CitT; pfam12431 362663013534 sensory histidine kinase DcuS; Provisional; Region: PRK11086 362663013535 PAS domain; Region: PAS; smart00091 362663013536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663013537 ATP binding site [chemical binding]; other site 362663013538 Mg2+ binding site [ion binding]; other site 362663013539 G-X-G motif; other site 362663013540 Uncharacterized conserved protein [Function unknown]; Region: COG3592 362663013541 Predicted acetyltransferase [General function prediction only]; Region: COG2388 362663013542 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 362663013543 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 362663013544 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 362663013545 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 362663013546 dimer interface [polypeptide binding]; other site 362663013547 putative anticodon binding site; other site 362663013548 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 362663013549 motif 1; other site 362663013550 active site 362663013551 motif 2; other site 362663013552 motif 3; other site 362663013553 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 362663013554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663013555 putative substrate translocation pore; other site 362663013556 POT family; Region: PTR2; pfam00854 362663013557 lysine decarboxylase CadA; Provisional; Region: PRK15400 362663013558 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 362663013559 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 362663013560 homodimer interface [polypeptide binding]; other site 362663013561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663013562 catalytic residue [active] 362663013563 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 362663013564 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 362663013565 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 362663013566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663013567 DNA binding site [nucleotide binding] 362663013568 putative transcriptional regulator; Provisional; Region: PRK11640 362663013569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663013570 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 362663013571 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 362663013572 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 362663013573 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 362663013574 DsbD alpha interface [polypeptide binding]; other site 362663013575 catalytic residues [active] 362663013576 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 362663013577 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 362663013578 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 362663013579 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 362663013580 Aspartase; Region: Aspartase; cd01357 362663013581 active sites [active] 362663013582 tetramer interface [polypeptide binding]; other site 362663013583 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 362663013584 putative transporter; Provisional; Region: PRK11021 362663013585 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 362663013586 oligomerisation interface [polypeptide binding]; other site 362663013587 mobile loop; other site 362663013588 roof hairpin; other site 362663013589 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 362663013590 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 362663013591 ring oligomerisation interface [polypeptide binding]; other site 362663013592 ATP/Mg binding site [chemical binding]; other site 362663013593 stacking interactions; other site 362663013594 hinge regions; other site 362663013595 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 362663013596 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 362663013597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663013598 FeS/SAM binding site; other site 362663013599 elongation factor P; Validated; Region: PRK00529 362663013600 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 362663013601 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 362663013602 RNA binding site [nucleotide binding]; other site 362663013603 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 362663013604 RNA binding site [nucleotide binding]; other site 362663013605 entericidin A; Provisional; Region: PRK09810 362663013606 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 362663013607 multidrug efflux system protein; Provisional; Region: PRK11431 362663013608 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 362663013609 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 362663013610 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 362663013611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 362663013612 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 362663013613 Iron-sulfur protein interface; other site 362663013614 proximal quinone binding site [chemical binding]; other site 362663013615 C-subunit interface; other site 362663013616 distal quinone binding site; other site 362663013617 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 362663013618 D-subunit interface [polypeptide binding]; other site 362663013619 Iron-sulfur protein interface; other site 362663013620 proximal quinone binding site [chemical binding]; other site 362663013621 distal quinone binding site [chemical binding]; other site 362663013622 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 362663013623 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 362663013624 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 362663013625 L-aspartate oxidase; Provisional; Region: PRK06175 362663013626 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 362663013627 poxB regulator PoxA; Provisional; Region: PRK09350 362663013628 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 362663013629 motif 1; other site 362663013630 dimer interface [polypeptide binding]; other site 362663013631 active site 362663013632 motif 2; other site 362663013633 motif 3; other site 362663013634 inner membrane transporter YjeM; Provisional; Region: PRK15238 362663013635 putative mechanosensitive channel protein; Provisional; Region: PRK10929 362663013636 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 362663013637 DNA-binding site [nucleotide binding]; DNA binding site 362663013638 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 362663013639 Mechanosensitive ion channel; Region: MS_channel; pfam00924 362663013640 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 362663013641 GTPase RsgA; Reviewed; Region: PRK12288 362663013642 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362663013643 RNA binding site [nucleotide binding]; other site 362663013644 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 362663013645 GTPase/Zn-binding domain interface [polypeptide binding]; other site 362663013646 GTP/Mg2+ binding site [chemical binding]; other site 362663013647 G4 box; other site 362663013648 G5 box; other site 362663013649 G1 box; other site 362663013650 Switch I region; other site 362663013651 G2 box; other site 362663013652 G3 box; other site 362663013653 Switch II region; other site 362663013654 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 362663013655 catalytic site [active] 362663013656 putative active site [active] 362663013657 putative substrate binding site [chemical binding]; other site 362663013658 dimer interface [polypeptide binding]; other site 362663013659 epoxyqueuosine reductase; Region: TIGR00276 362663013660 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 362663013661 putative carbohydrate kinase; Provisional; Region: PRK10565 362663013662 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 362663013663 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 362663013664 putative substrate binding site [chemical binding]; other site 362663013665 putative ATP binding site [chemical binding]; other site 362663013666 ADP-binding protein; Provisional; Region: PRK10646 362663013667 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 362663013668 AMIN domain; Region: AMIN; pfam11741 362663013669 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 362663013670 active site 362663013671 metal binding site [ion binding]; metal-binding site 362663013672 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 362663013673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663013674 ATP binding site [chemical binding]; other site 362663013675 Mg2+ binding site [ion binding]; other site 362663013676 G-X-G motif; other site 362663013677 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 362663013678 ATP binding site [chemical binding]; other site 362663013679 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 362663013680 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 362663013681 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 362663013682 bacterial Hfq-like; Region: Hfq; cd01716 362663013683 hexamer interface [polypeptide binding]; other site 362663013684 Sm1 motif; other site 362663013685 RNA binding site [nucleotide binding]; other site 362663013686 Sm2 motif; other site 362663013687 GTPase HflX; Provisional; Region: PRK11058 362663013688 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 362663013689 HflX GTPase family; Region: HflX; cd01878 362663013690 G1 box; other site 362663013691 GTP/Mg2+ binding site [chemical binding]; other site 362663013692 Switch I region; other site 362663013693 G2 box; other site 362663013694 G3 box; other site 362663013695 Switch II region; other site 362663013696 G4 box; other site 362663013697 G5 box; other site 362663013698 FtsH protease regulator HflK; Provisional; Region: PRK10930 362663013699 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 362663013700 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 362663013701 FtsH protease regulator HflC; Provisional; Region: PRK11029 362663013702 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 362663013703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 362663013704 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 362663013705 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 362663013706 GDP-binding site [chemical binding]; other site 362663013707 ACT binding site; other site 362663013708 IMP binding site; other site 362663013709 Predicted transcriptional regulator [Transcription]; Region: COG1959 362663013710 transcriptional repressor NsrR; Provisional; Region: PRK11014 362663013711 exoribonuclease R; Provisional; Region: PRK11642 362663013712 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 362663013713 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 362663013714 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 362663013715 RNB domain; Region: RNB; pfam00773 362663013716 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 362663013717 RNA binding site [nucleotide binding]; other site 362663013718 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 362663013719 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 362663013720 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 362663013721 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 362663013722 PspA/IM30 family; Region: PspA_IM30; pfam04012 362663013723 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 362663013724 Predicted membrane protein [Function unknown]; Region: COG3766 362663013725 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 362663013726 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 362663013727 Predicted integral membrane protein [Function unknown]; Region: COG5463 362663013728 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 362663013729 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 362663013730 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 362663013731 FAD binding site [chemical binding]; other site 362663013732 substrate binding site [chemical binding]; other site 362663013733 catalytic residues [active] 362663013734 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663013735 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 362663013736 esterase; Provisional; Region: PRK10566 362663013737 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 362663013738 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 362663013739 transcriptional repressor UlaR; Provisional; Region: PRK13509 362663013740 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 362663013741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 362663013742 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 362663013743 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 362663013744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 362663013745 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 362663013746 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 362663013747 active site 362663013748 P-loop; other site 362663013749 phosphorylation site [posttranslational modification] 362663013750 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 362663013751 active site 362663013752 phosphorylation site [posttranslational modification] 362663013753 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 362663013754 active site 362663013755 dimer interface [polypeptide binding]; other site 362663013756 magnesium binding site [ion binding]; other site 362663013757 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 362663013758 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 362663013759 AP (apurinic/apyrimidinic) site pocket; other site 362663013760 DNA interaction; other site 362663013761 Metal-binding active site; metal-binding site 362663013762 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 362663013763 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 362663013764 intersubunit interface [polypeptide binding]; other site 362663013765 active site 362663013766 Zn2+ binding site [ion binding]; other site 362663013767 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 362663013768 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 362663013769 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 362663013770 dimer interface [polypeptide binding]; other site 362663013771 ssDNA binding site [nucleotide binding]; other site 362663013772 tetramer (dimer of dimers) interface [polypeptide binding]; other site 362663013773 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 362663013774 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 362663013775 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 362663013776 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 362663013777 Helix-turn-helix domain; Region: HTH_31; pfam13560 362663013778 sequence-specific DNA binding site [nucleotide binding]; other site 362663013779 salt bridge; other site 362663013780 HipA-like N-terminal domain; Region: HipA_N; pfam07805 362663013781 HipA-like C-terminal domain; Region: HipA_C; pfam07804 362663013782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 362663013783 D-galactonate transporter; Region: 2A0114; TIGR00893 362663013784 putative substrate translocation pore; other site 362663013785 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 362663013786 L-aspartate oxidase; Provisional; Region: PRK06175 362663013787 L-aspartate oxidase; Provisional; Region: PRK06175 362663013788 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 362663013789 Coenzyme A transferase; Region: CoA_trans; smart00882 362663013790 Coenzyme A transferase; Region: CoA_trans; cl17247 362663013791 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 362663013792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 362663013793 substrate binding site [chemical binding]; other site 362663013794 oxyanion hole (OAH) forming residues; other site 362663013795 trimer interface [polypeptide binding]; other site 362663013796 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 362663013797 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 362663013798 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 362663013799 putative NAD(P) binding site [chemical binding]; other site 362663013800 active site 362663013801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663013802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663013803 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 362663013804 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 362663013805 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 362663013806 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 362663013807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 362663013808 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 362663013809 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 362663013810 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 362663013811 Hemerythrin-like domain; Region: Hr-like; cd12108 362663013812 Fe binding site [ion binding]; other site 362663013813 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 362663013814 EamA-like transporter family; Region: EamA; pfam00892 362663013815 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 362663013816 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 362663013817 NADP binding site [chemical binding]; other site 362663013818 Predicted transcriptional regulators [Transcription]; Region: COG1733 362663013819 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 362663013820 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 362663013821 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 362663013822 active site 362663013823 metal binding site [ion binding]; metal-binding site 362663013824 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 362663013825 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 362663013826 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 362663013827 active site 362663013828 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 362663013829 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 362663013830 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 362663013831 Domain of unknown function DUF21; Region: DUF21; pfam01595 362663013832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 362663013833 Transporter associated domain; Region: CorC_HlyC; smart01091 362663013834 methionine sulfoxide reductase A; Provisional; Region: PRK00058 362663013835 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 362663013836 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 362663013837 Surface antigen; Region: Bac_surface_Ag; pfam01103 362663013838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 362663013839 Family of unknown function (DUF490); Region: DUF490; pfam04357 362663013840 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 362663013841 putative active site pocket [active] 362663013842 dimerization interface [polypeptide binding]; other site 362663013843 putative catalytic residue [active] 362663013844 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 362663013845 dimer interface [polypeptide binding]; other site 362663013846 substrate binding site [chemical binding]; other site 362663013847 metal binding sites [ion binding]; metal-binding site 362663013848 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 362663013849 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 362663013850 putative ligand binding site [chemical binding]; other site 362663013851 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 362663013852 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 362663013853 Walker A/P-loop; other site 362663013854 ATP binding site [chemical binding]; other site 362663013855 Q-loop/lid; other site 362663013856 ABC transporter signature motif; other site 362663013857 Walker B; other site 362663013858 D-loop; other site 362663013859 H-loop/switch region; other site 362663013860 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 362663013861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663013862 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663013863 TM-ABC transporter signature motif; other site 362663013864 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 362663013865 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 362663013866 TM-ABC transporter signature motif; other site 362663013867 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 362663013868 AMP binding site [chemical binding]; other site 362663013869 metal binding site [ion binding]; metal-binding site 362663013870 active site 362663013871 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 362663013872 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 362663013873 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 362663013874 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 362663013875 hypothetical protein; Provisional; Region: PRK05255 362663013876 peptidase PmbA; Provisional; Region: PRK11040 362663013877 cytochrome b562; Provisional; Region: PRK15058 362663013878 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 362663013879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663013880 FeS/SAM binding site; other site 362663013881 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 362663013882 ATP cone domain; Region: ATP-cone; pfam03477 362663013883 Class III ribonucleotide reductase; Region: RNR_III; cd01675 362663013884 effector binding site; other site 362663013885 active site 362663013886 Zn binding site [ion binding]; other site 362663013887 glycine loop; other site 362663013888 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 362663013889 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 362663013890 Ca binding site [ion binding]; other site 362663013891 active site 362663013892 catalytic site [active] 362663013893 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 362663013894 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 362663013895 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 362663013896 active site turn [active] 362663013897 phosphorylation site [posttranslational modification] 362663013898 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 362663013899 trehalose repressor; Provisional; Region: treR; PRK09492 362663013900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663013901 DNA binding site [nucleotide binding] 362663013902 domain linker motif; other site 362663013903 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 362663013904 dimerization interface [polypeptide binding]; other site 362663013905 ligand binding site [chemical binding]; other site 362663013906 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 362663013907 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 362663013908 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 362663013909 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 362663013910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663013911 motif II; other site 362663013912 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 362663013913 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 362663013914 homotrimer interaction site [polypeptide binding]; other site 362663013915 putative active site [active] 362663013916 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 362663013917 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 362663013918 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 362663013919 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 362663013920 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 362663013921 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 362663013922 Arginine repressor [Transcription]; Region: ArgR; COG1438 362663013923 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 362663013924 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 362663013925 Predicted membrane protein [Function unknown]; Region: COG1288 362663013926 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 362663013927 ornithine carbamoyltransferase; Validated; Region: PRK02102 362663013928 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 362663013929 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 362663013930 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 362663013931 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 362663013932 putative substrate binding site [chemical binding]; other site 362663013933 nucleotide binding site [chemical binding]; other site 362663013934 nucleotide binding site [chemical binding]; other site 362663013935 homodimer interface [polypeptide binding]; other site 362663013936 arginine deiminase; Provisional; Region: PRK01388 362663013937 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 362663013938 ornithine carbamoyltransferase chain I nonfunction due to the frame shift 362663013939 ornithine carbamoyltransferase chain I nonfunction due to the frame shift 362663013940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 362663013941 RNase E inhibitor protein; Provisional; Region: PRK11191 362663013942 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 362663013943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663013944 Coenzyme A binding pocket [chemical binding]; other site 362663013945 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 362663013946 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 362663013947 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 362663013948 HIGH motif; other site 362663013949 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 362663013950 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 362663013951 active site 362663013952 KMSKS motif; other site 362663013953 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 362663013954 tRNA binding surface [nucleotide binding]; other site 362663013955 anticodon binding site; other site 362663013956 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 362663013957 DNA polymerase III subunit chi; Validated; Region: PRK05728 362663013958 multifunctional aminopeptidase A; Provisional; Region: PRK00913 362663013959 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 362663013960 interface (dimer of trimers) [polypeptide binding]; other site 362663013961 Substrate-binding/catalytic site; other site 362663013962 Zn-binding sites [ion binding]; other site 362663013963 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 362663013964 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 362663013965 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 362663013966 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 362663013967 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 362663013968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 362663013969 Walker A motif; other site 362663013970 ATP binding site [chemical binding]; other site 362663013971 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 362663013972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 362663013973 DNA binding site [nucleotide binding] 362663013974 domain linker motif; other site 362663013975 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 362663013976 putative dimerization interface [polypeptide binding]; other site 362663013977 putative ligand binding site [chemical binding]; other site 362663013978 fructuronate transporter; Provisional; Region: PRK10034; cl15264 362663013979 gluconate transporter; Region: gntP; TIGR00791 362663013980 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 362663013981 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 362663013982 NADP binding site [chemical binding]; other site 362663013983 homodimer interface [polypeptide binding]; other site 362663013984 active site 362663013985 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 362663013986 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 362663013987 putative NAD(P) binding site [chemical binding]; other site 362663013988 catalytic Zn binding site [ion binding]; other site 362663013989 N-terminal part of thermosensitive gluconokinase nonfunctional due to the frameshift 362663013990 C-terminal part of thermosensitive gluconokinase nonfunctional due to the frameshift 362663013991 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 362663013992 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 362663013993 putative NAD(P) binding site [chemical binding]; other site 362663013994 putative substrate binding site [chemical binding]; other site 362663013995 catalytic Zn binding site [ion binding]; other site 362663013996 structural Zn binding site [ion binding]; other site 362663013997 dimer interface [polypeptide binding]; other site 362663013998 integrase; Provisional; Region: PRK09692 362663013999 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 362663014000 active site 362663014001 Int/Topo IB signature motif; other site 362663014002 Part of AAA domain; Region: AAA_19; pfam13245 362663014003 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 362663014004 AAA domain; Region: AAA_12; pfam13087 362663014005 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 362663014006 putative active site [active] 362663014007 catalytic site [active] 362663014008 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 362663014009 Sulfatase; Region: Sulfatase; cl17466 362663014010 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 362663014011 MarR family; Region: MarR_2; cl17246 362663014012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 362663014013 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 362663014014 putative membrane interaction site; other site 362663014015 receptor/carbohydrate binding site; other site 362663014016 PapG chaperone-binding domain; Region: PapG_C; pfam03628 362663014017 Fimbrial protein; Region: Fimbrial; pfam00419 362663014018 Fimbrial protein; Region: Fimbrial; pfam00419 362663014019 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014020 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 362663014021 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663014022 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663014023 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 362663014024 PapC N-terminal domain; Region: PapC_N; pfam13954 362663014025 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663014026 PapC C-terminal domain; Region: PapC_C; pfam13953 362663014027 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014028 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014029 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 362663014030 Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683 362663014031 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 362663014032 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 362663014033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663014034 Transposase; Region: HTH_Tnp_1; cl17663 362663014035 Integrase core domain; Region: rve; pfam00665 362663014036 Transposase; Region: DEDD_Tnp_IS110; pfam01548 362663014037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 362663014038 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 362663014039 Integrase core domain; Region: rve_3; pfam13683 362663014040 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 362663014041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 362663014042 HlyD family secretion protein; Region: HlyD_3; pfam13437 362663014043 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 362663014044 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 362663014045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 362663014046 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 362663014047 Walker A/P-loop; other site 362663014048 ATP binding site [chemical binding]; other site 362663014049 Q-loop/lid; other site 362663014050 ABC transporter signature motif; other site 362663014051 Walker B; other site 362663014052 D-loop; other site 362663014053 H-loop/switch region; other site 362663014054 RTX N-terminal domain; Region: RTX; pfam02382 362663014055 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 362663014056 RTX C-terminal domain; Region: RTX_C; pfam08339 362663014057 RTX toxin acyltransferase family; Region: HlyC; pfam02794 362663014058 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 362663014059 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 362663014060 Moco binding site; other site 362663014061 metal coordination site [ion binding]; other site 362663014062 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 362663014063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 362663014064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663014065 active site 362663014066 phosphorylation site [posttranslational modification] 362663014067 intermolecular recognition site; other site 362663014068 dimerization interface [polypeptide binding]; other site 362663014069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663014070 DNA binding site [nucleotide binding] 362663014071 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 362663014072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663014073 ATP binding site [chemical binding]; other site 362663014074 Mg2+ binding site [ion binding]; other site 362663014075 G-X-G motif; other site 362663014076 Integrase core domain; Region: rve; pfam00665 362663014077 Integrase core domain; Region: rve_3; cl15866 362663014078 Transposase; Region: HTH_Tnp_1; pfam01527 362663014079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663014080 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 362663014081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 362663014082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663014083 ATP binding site [chemical binding]; other site 362663014084 Mg2+ binding site [ion binding]; other site 362663014085 G-X-G motif; other site 362663014086 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 362663014087 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 362663014088 cofactor binding site; other site 362663014089 DNA binding site [nucleotide binding] 362663014090 substrate interaction site [chemical binding]; other site 362663014091 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 362663014092 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 362663014093 ImpA domain protein; Region: DUF3702; pfam12486 362663014094 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 362663014095 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 362663014096 haemagglutination activity domain; Region: Haemagg_act; pfam05860 362663014097 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 362663014098 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 362663014099 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 362663014100 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 362663014101 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 362663014102 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 362663014103 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 362663014104 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663014105 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 362663014106 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663014107 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 362663014108 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 362663014109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 362663014110 catalytic residue [active] 362663014111 permease DsdX; Provisional; Region: PRK09921 362663014112 gluconate transporter; Region: gntP; TIGR00791 362663014113 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 362663014114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663014115 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 362663014116 dimerization interface [polypeptide binding]; other site 362663014117 substrate binding pocket [chemical binding]; other site 362663014118 Integrase core domain; Region: rve; pfam00665 362663014119 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 362663014120 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 362663014121 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 362663014122 Propanediol utilisation protein PduL; Region: PduL; pfam06130 362663014123 Propanediol utilisation protein PduL; Region: PduL; pfam06130 362663014124 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 362663014125 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 362663014126 Hexamer interface [polypeptide binding]; other site 362663014127 Hexagonal pore residue; other site 362663014128 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 362663014129 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 362663014130 Pyruvate formate lyase; Region: PFL; pfam02901 362663014131 Pyruvate formate lyase; Region: PFL; pfam02901 362663014132 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 362663014133 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 362663014134 dimer interface [polypeptide binding]; other site 362663014135 active site 362663014136 glycine loop; other site 362663014137 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 362663014138 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 362663014139 putative active site [active] 362663014140 metal binding site [ion binding]; metal-binding site 362663014141 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 362663014142 Hexamer/Pentamer interface [polypeptide binding]; other site 362663014143 central pore; other site 362663014144 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 362663014145 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 362663014146 putative catalytic cysteine [active] 362663014147 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 362663014148 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 362663014149 Hexamer interface [polypeptide binding]; other site 362663014150 Hexagonal pore residue; other site 362663014151 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 362663014152 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 362663014153 Hexamer interface [polypeptide binding]; other site 362663014154 Hexagonal pore residue; other site 362663014155 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 362663014156 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 362663014157 Hexamer interface [polypeptide binding]; other site 362663014158 Hexagonal pore residue; other site 362663014159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 362663014160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 362663014161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 362663014162 putative transposase OrfB; Reviewed; Region: PHA02517 362663014163 HTH-like domain; Region: HTH_21; pfam13276 362663014164 Integrase core domain; Region: rve; pfam00665 362663014165 Integrase core domain; Region: rve_3; cl15866 362663014166 Transposase; Region: HTH_Tnp_1; cl17663 362663014167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663014168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 362663014169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 362663014170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 362663014171 homodimer interface [polypeptide binding]; other site 362663014172 catalytic residue [active] 362663014173 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 362663014174 transposase/IS protein; Provisional; Region: PRK09183 362663014175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663014176 Walker A motif; other site 362663014177 ATP binding site [chemical binding]; other site 362663014178 Walker B motif; other site 362663014179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 362663014180 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 362663014181 DNA-binding interface [nucleotide binding]; DNA binding site 362663014182 Integrase core domain; Region: rve; pfam00665 362663014183 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 362663014184 Transposase; Region: HTH_Tnp_1; cl17663 362663014185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 362663014186 Transposase; Region: HTH_Tnp_1; cl17663 362663014187 Integrase core domain; Region: rve; pfam00665 362663014188 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 362663014189 Restriction endonuclease; Region: Mrr_cat; pfam04471 362663014190 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 362663014191 Predicted GTPase [General function prediction only]; Region: COG3596 362663014192 YfjP GTPase; Region: YfjP; cd11383 362663014193 G1 box; other site 362663014194 GTP/Mg2+ binding site [chemical binding]; other site 362663014195 Switch I region; other site 362663014196 G2 box; other site 362663014197 Switch II region; other site 362663014198 G3 box; other site 362663014199 G4 box; other site 362663014200 G5 box; other site 362663014201 HTH domain; Region: HTH_11; cl17392 362663014202 WYL domain; Region: WYL; pfam13280 362663014203 Domain of unknown function (DUF932); Region: DUF932; pfam06067 362663014204 Antirestriction protein; Region: Antirestrict; pfam03230 362663014205 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 362663014206 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 362663014207 MPN+ (JAMM) motif; other site 362663014208 Zinc-binding site [ion binding]; other site 362663014209 Protein of unknown function (DUF987); Region: DUF987; pfam06174 362663014210 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 362663014211 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 362663014212 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 362663014213 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 362663014214 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 362663014215 HNH endonuclease; Region: HNH_2; pfam13391 362663014216 Domain of unknown function (DUF303); Region: DUF303; pfam03629 362663014217 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 362663014218 Kelch motif; Region: Kelch_1; pfam01344 362663014219 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 362663014220 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 362663014221 Int/Topo IB signature motif; other site 362663014222 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 362663014223 Int/Topo IB signature motif; other site 362663014224 Fimbrial protein; Region: Fimbrial; cl01416 362663014225 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014226 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 362663014227 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 362663014228 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 362663014229 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 362663014230 PapC N-terminal domain; Region: PapC_N; pfam13954 362663014231 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 362663014232 PapC C-terminal domain; Region: PapC_C; pfam13953 362663014233 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014234 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 362663014235 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 362663014236 mannosyl binding site [chemical binding]; other site 362663014237 Fimbrial protein; Region: Fimbrial; pfam00419 362663014238 mannonate dehydratase; Region: uxuA; TIGR00695 362663014239 mannonate dehydratase; Provisional; Region: PRK03906 362663014240 D-mannonate oxidoreductase; Provisional; Region: PRK15037 362663014241 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 362663014242 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 362663014243 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 362663014244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663014245 DNA-binding site [nucleotide binding]; DNA binding site 362663014246 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663014247 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 362663014248 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 362663014249 cell density-dependent motility repressor; Provisional; Region: PRK10082 362663014250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 362663014251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 362663014252 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 362663014253 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 362663014254 dimer interface [polypeptide binding]; other site 362663014255 active site 362663014256 hypothetical protein; Provisional; Region: PRK10519 362663014257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 362663014258 Nucleoside recognition; Region: Gate; pfam07670 362663014259 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 362663014260 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 362663014261 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 362663014262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 362663014263 SdiA-regulated; Region: SdiA-regulated; cd09971 362663014264 putative active site [active] 362663014265 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 362663014266 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 362663014267 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 362663014268 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 362663014269 Predicted membrane protein [Function unknown]; Region: COG2733 362663014270 putative transposase; Provisional; Region: PRK09857 362663014271 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 362663014272 Uncharacterized conserved protein [Function unknown]; Region: COG1479 362663014273 Protein of unknown function DUF262; Region: DUF262; pfam03235 362663014274 Protein of unknown function DUF262; Region: DUF262; pfam03235 362663014275 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 362663014276 Uncharacterized conserved protein [Function unknown]; Region: COG3586 362663014277 endoribonuclease SymE; Provisional; Region: PRK13605 362663014278 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 362663014279 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 362663014280 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 362663014281 HsdM N-terminal domain; Region: HsdM_N; pfam12161 362663014282 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 362663014283 Methyltransferase domain; Region: Methyltransf_26; pfam13659 362663014284 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 362663014285 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 362663014286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 362663014287 ATP binding site [chemical binding]; other site 362663014288 putative Mg++ binding site [ion binding]; other site 362663014289 Uncharacterized conserved protein [Function unknown]; Region: COG1479 362663014290 Protein of unknown function DUF262; Region: DUF262; pfam03235 362663014291 Protein of unknown function DUF262; Region: DUF262; pfam03235 362663014292 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 362663014293 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 362663014294 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 362663014295 P-loop, Walker A motif; other site 362663014296 Base recognition motif; other site 362663014297 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 362663014298 Uncharacterized small protein [Function unknown]; Region: COG2879 362663014299 carbon starvation protein A; Provisional; Region: PRK15015 362663014300 Carbon starvation protein CstA; Region: CstA; pfam02554 362663014301 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 362663014302 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 362663014303 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 362663014304 dimer interface [polypeptide binding]; other site 362663014305 ligand binding site [chemical binding]; other site 362663014306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663014307 dimerization interface [polypeptide binding]; other site 362663014308 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 362663014309 dimer interface [polypeptide binding]; other site 362663014310 putative CheW interface [polypeptide binding]; other site 362663014311 DctM-like transporters; Region: DctM; pfam06808 362663014312 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 362663014313 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 362663014314 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 362663014315 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 362663014316 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 362663014317 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 362663014318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 362663014319 DNA-binding site [nucleotide binding]; DNA binding site 362663014320 Transcriptional regulators [Transcription]; Region: GntR; COG1802 362663014321 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 362663014322 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 362663014323 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 362663014324 putative NAD(P) binding site [chemical binding]; other site 362663014325 catalytic Zn binding site [ion binding]; other site 362663014326 structural Zn binding site [ion binding]; other site 362663014327 phosphoglycerol transferase I; Provisional; Region: PRK03776 362663014328 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 362663014329 hypothetical protein; Provisional; Region: PRK11667 362663014330 DNA replication protein DnaC; Validated; Region: PRK07952 362663014331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 362663014332 Walker A motif; other site 362663014333 ATP binding site [chemical binding]; other site 362663014334 Walker B motif; other site 362663014335 primosomal protein DnaI; Provisional; Region: PRK02854 362663014336 hypothetical protein; Provisional; Region: PRK09917 362663014337 Uncharacterized conserved protein [Function unknown]; Region: COG2966 362663014338 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 362663014339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 362663014340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663014341 DNA binding residues [nucleotide binding] 362663014342 dimerization interface [polypeptide binding]; other site 362663014343 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 362663014344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 362663014345 DNA binding residues [nucleotide binding] 362663014346 dimerization interface [polypeptide binding]; other site 362663014347 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 362663014348 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 362663014349 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 362663014350 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 362663014351 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 362663014352 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 362663014353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 362663014354 S-adenosylmethionine binding site [chemical binding]; other site 362663014355 DNA polymerase III subunit psi; Validated; Region: PRK06856 362663014356 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 362663014357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 362663014358 Coenzyme A binding pocket [chemical binding]; other site 362663014359 dUMP phosphatase; Provisional; Region: PRK09449 362663014360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663014361 motif II; other site 362663014362 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 362663014363 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 362663014364 G1 box; other site 362663014365 putative GEF interaction site [polypeptide binding]; other site 362663014366 GTP/Mg2+ binding site [chemical binding]; other site 362663014367 Switch I region; other site 362663014368 G2 box; other site 362663014369 G3 box; other site 362663014370 Switch II region; other site 362663014371 G4 box; other site 362663014372 G5 box; other site 362663014373 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 362663014374 periplasmic protein; Provisional; Region: PRK10568 362663014375 BON domain; Region: BON; pfam04972 362663014376 BON domain; Region: BON; pfam04972 362663014377 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 362663014378 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 362663014379 active site 362663014380 nucleophile elbow; other site 362663014381 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 362663014382 active site 362663014383 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 362663014384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 362663014385 FeS/SAM binding site; other site 362663014386 hypothetical protein; Provisional; Region: PRK10977 362663014387 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 362663014388 intersubunit interface [polypeptide binding]; other site 362663014389 active site 362663014390 catalytic residue [active] 362663014391 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 362663014392 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 362663014393 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 362663014394 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 362663014395 phosphopentomutase; Provisional; Region: PRK05362 362663014396 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 362663014397 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 362663014398 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 362663014399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663014400 non-specific DNA binding site [nucleotide binding]; other site 362663014401 salt bridge; other site 362663014402 sequence-specific DNA binding site [nucleotide binding]; other site 362663014403 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 362663014404 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 362663014405 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 362663014406 hypothetical protein; Provisional; Region: PRK11246 362663014407 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 362663014408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 362663014409 motif II; other site 362663014410 DNA repair protein RadA; Region: sms; TIGR00416 362663014411 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 362663014412 Walker A motif/ATP binding site; other site 362663014413 ATP binding site [chemical binding]; other site 362663014414 Walker B motif; other site 362663014415 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 362663014416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663014417 non-specific DNA binding site [nucleotide binding]; other site 362663014418 salt bridge; other site 362663014419 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 362663014420 sequence-specific DNA binding site [nucleotide binding]; other site 362663014421 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 362663014422 active site 362663014423 (T/H)XGH motif; other site 362663014424 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 362663014425 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 362663014426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 362663014427 non-specific DNA binding site [nucleotide binding]; other site 362663014428 salt bridge; other site 362663014429 sequence-specific DNA binding site [nucleotide binding]; other site 362663014430 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 362663014431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 362663014432 Walker A/P-loop; other site 362663014433 ATP binding site [chemical binding]; other site 362663014434 Q-loop/lid; other site 362663014435 ABC transporter signature motif; other site 362663014436 Walker B; other site 362663014437 D-loop; other site 362663014438 H-loop/switch region; other site 362663014439 ABC transporter; Region: ABC_tran_2; pfam12848 362663014440 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 362663014441 lytic murein transglycosylase; Provisional; Region: PRK11619 362663014442 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 362663014443 N-acetyl-D-glucosamine binding site [chemical binding]; other site 362663014444 catalytic residue [active] 362663014445 Trp operon repressor; Provisional; Region: PRK01381 362663014446 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 362663014447 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 362663014448 catalytic core [active] 362663014449 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 362663014450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 362663014451 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 362663014452 hypothetical protein; Provisional; Region: PRK10756 362663014453 CreA protein; Region: CreA; pfam05981 362663014454 DNA-binding response regulator CreB; Provisional; Region: PRK11083 362663014455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663014456 active site 362663014457 phosphorylation site [posttranslational modification] 362663014458 intermolecular recognition site; other site 362663014459 dimerization interface [polypeptide binding]; other site 362663014460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663014461 DNA binding site [nucleotide binding] 362663014462 sensory histidine kinase CreC; Provisional; Region: PRK11100 362663014463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 362663014464 dimerization interface [polypeptide binding]; other site 362663014465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 362663014466 dimer interface [polypeptide binding]; other site 362663014467 phosphorylation site [posttranslational modification] 362663014468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 362663014469 ATP binding site [chemical binding]; other site 362663014470 Mg2+ binding site [ion binding]; other site 362663014471 G-X-G motif; other site 362663014472 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 362663014473 two-component response regulator; Provisional; Region: PRK11173 362663014474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 362663014475 active site 362663014476 phosphorylation site [posttranslational modification] 362663014477 intermolecular recognition site; other site 362663014478 dimerization interface [polypeptide binding]; other site 362663014479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 362663014480 DNA binding site [nucleotide binding] 362663014481 hypothetical tRNA/rRNA methyltransferase LasT nonfunction due to the frame shift 362663014482 hypothetical tRNA/rRNA methyltransferase LasT nonfunction due to the frame shift